Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
SDF4	51150	broad.mit.edu	37	1	1153867	1153867	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1153867C>T	uc001adh.3	-	6	1212	c.883G>A	c.(883-885)GAC>AAC	p.D295N	SDF4_uc001adg.2_RNA|SDF4_uc001adi.3_Missense_Mutation_p.D295N|SDF4_uc009vjv.2_Missense_Mutation_p.D173N|SDF4_uc009vjw.2_RNA	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	295	EF-hand 5.|5 (Potential).				cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		ACGATGCCGTCGTGGTTGGAG	0.642		NaN											0	0	0	0.001855	0	12	30									
FAM132A	388581	broad.mit.edu	37	1	1178268	1178268	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1178268C>G	uc001adl.1	-	7	789	c.757G>C	c.(757-759)GAG>CAG	p.E253Q		NM_001014980	NP_001014980	Q5T7M4	F132A_HUMAN	family with sequence similarity 132, member A	253						extracellular region					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CTGTTGCTCTCCAGGCCTGAG	0.682		NaN											0	0	0	0.009096	0	3	28									
SCNN1D	6339	broad.mit.edu	37	1	1225697	1225697	+	Missense_Mutation	SNP	C	C	T	rs137911309	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1225697C>T	uc001adu.1	+	12	1841	c.1217C>T	c.(1216-1218)TCC>TTC	p.S406F	SCNN1D_uc001adt.1_Missense_Mutation_p.S570F|SCNN1D_uc001adw.2_Missense_Mutation_p.S472F|SCNN1D_uc001adx.2_Missense_Mutation_p.S195F|SCNN1D_uc001adv.2_Missense_Mutation_p.S406F	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GAGACCTGCTCCTGTGGCTAC	0.672		NaN											0	0	0	0.008291	0	4	15									
SCNN1D	6339	broad.mit.edu	37	1	1226989	1226989	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1226989G>A	uc001adu.1	+	17	2540	c.1916G>A	c.(1915-1917)TGA>TAA	p.*639*	SCNN1D_uc001adt.1_Silent_p.*803*|SCNN1D_uc001adw.2_Silent_p.*705*|SCNN1D_uc001adx.2_Silent_p.*428*|SCNN1D_uc001adv.2_Silent_p.*639*	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		CTGGACACCTGAACCAGACCT	0.677		NaN											0	0	0	0.012213	0	29	17									
PUSL1	126789	broad.mit.edu	37	1	1244841	1244841	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1244841C>T	uc001aed.2	+	4	361	c.331C>T	c.(331-333)CGG>TGG	p.R111W	ACAP3_uc001aeb.2_5'Flank|ACAP3_uc001aec.1_5'UTR|PUSL1_uc010nyi.1_5'UTR|PUSL1_uc009vjx.2_5'UTR	NM_153339	NP_699170	Q8N0Z8	PUSL1_HUMAN	pseudouridylate synthase-like 1	111					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.95e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TAGGGTCCTGCGGGCCTTCCG	0.672		NaN											0	0	0	0.001984	0	6	5									
MXRA8	54587	broad.mit.edu	37	1	1290312	1290312	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1290312G>A	uc001aew.2	-	5	730	c.699C>T	c.(697-699)GCC>GCT	p.A233A	MXRA8_uc001aex.3_Silent_p.A233A|MXRA8_uc001aey.3_Silent_p.A233A|MXRA8_uc010nyl.1_Silent_p.A233A|MXRA8_uc001aez.2_Silent_p.A132A|MXRA8_uc001afa.2_Silent_p.A224A	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	233	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGGGCCCGTAGGCGCGGCGCT	0.721		NaN											0	0	0	0.000602	0	4	8									
CCNL2	81669	broad.mit.edu	37	1	1334489	1334489	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1334489C>T	uc001afi.2	-	1	230	c.198G>A	c.(196-198)TCG>TCA	p.S66S	CCNL2_uc001afg.1_5'Flank|CCNL2_uc001afh.2_Silent_p.S66S|CCNL2_uc001afj.2_Silent_p.S66S|CCNL2_uc001afk.2_Silent_p.S66S|LOC148413_uc001afm.2_5'Flank|LOC148413_uc001afn.1_5'Flank|LOC148413_uc009vkc.1_5'Flank|LOC148413_uc009vkd.2_5'Flank	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	66					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CGAGGCCGCTCGACATGGACG	0.672		NaN											0	0	0	0.001168	0	4	36									
ATAD3A	55210	broad.mit.edu	37	1	1459719	1459719	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1459719C>T	uc001afz.1	+	11	1394	c.1300C>T	c.(1300-1302)CGG>TGG	p.R434W	ATAD3A_uc001aga.1_Missense_Mutation_p.R386W|ATAD3A_uc001agb.1_Missense_Mutation_p.R307W	NM_018188	NP_060658	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	434							ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		CCCCATGGGGCGGGAAGGCGT	0.647		NaN											0	0	0	0.010729	0	8	59									
GNB1	2782	broad.mit.edu	37	1	1720630	1720630	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1720630C>T	uc001aif.2	-	10	1110	c.778G>A	c.(778-780)GAG>AAG	p.E260K	GNB1_uc009vky.2_Missense_Mutation_p.E160K	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	260					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		GTCATGAGCTCCTGGTCAGCA	0.527		NaN									OREG0012998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007835	0	39	31									
GNB1	2782	broad.mit.edu	37	1	1720636	1720636	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:1720636C>T	uc001aif.2	-	10	1104	c.772G>A	c.(772-774)GAC>AAC	p.D258N	GNB1_uc009vky.2_Missense_Mutation_p.D158N	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	258					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		AGCTCCTGGTCAGCACGAAGG	0.532		NaN									OREG0012998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	9	61									
C1orf86	199990	broad.mit.edu	37	1	2125482	2125482	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:2125482C>T	uc001aiy.2	-	2	179	c.153G>A	c.(151-153)CTG>CTA	p.L51L	C1orf86_uc001aiv.1_RNA|C1orf86_uc001aiw.1_RNA|C1orf86_uc001aix.1_Intron	NM_182533	NP_872339	Q6NZ36	CA086_HUMAN	hypothetical protein LOC199990 isoform 2	51											0	all_cancers(77;0.000134)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.09e-37)|OV - Ovarian serous cystadenocarcinoma(86;1.5e-23)|GBM - Glioblastoma multiforme(42;1.61e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00437)|STAD - Stomach adenocarcinoma(132;0.0134)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GATCCAGGATCAGCTCCGGGC	0.677		NaN											0	0	0	0.00333	0	24	58									
MORN1	79906	broad.mit.edu	37	1	2268254	2268254	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:2268254G>A	uc001ajb.1	-	11	1093	c.1072C>T	c.(1072-1074)CAG>TAG	p.Q358*	MORN1_uc009vld.2_Nonsense_Mutation_p.Q334*	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	MORN repeat containing 1	358										ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		TCCACTCGCTGACAGGCCCCG	0.652		NaN											0	0	0	0.001855	0	11	15									
C1orf93	127281	broad.mit.edu	37	1	2520475	2520475	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:2520475C>G	uc001aju.1	+	6	651	c.575C>G	c.(574-576)CCT>CGT	p.P192R	C1orf93_uc001ajw.1_Silent_p.A181A|C1orf93_uc001ajv.1_Missense_Mutation_p.P210R|C1orf93_uc010nzd.1_Missense_Mutation_p.P188R|C1orf93_uc010nze.1_Missense_Mutation_p.P156R|C1orf93_uc010nzf.1_Missense_Mutation_p.P155R|C1orf93_uc001ajx.1_Missense_Mutation_p.L65V	NM_152371	NP_689584	Q8TBF2	PGFS_HUMAN	hypothetical protein LOC127281	192					prostaglandin biosynthetic process	cytosol	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor			central_nervous_system(1)	1	all_cancers(77;0.000167)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.97e-16)|all_lung(118;3.05e-07)|Lung NSC(185;2.8e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Lung SC(97;0.109)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Epithelial(90;4.76e-38)|OV - Ovarian serous cystadenocarcinoma(86;6.19e-23)|GBM - Glioblastoma multiforme(42;1.13e-08)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.00205)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.199)		AGCGACCCGCCTCAGGTGAGC	0.682		NaN											0	0	0	0.004007	0	15	29									
PRDM16	63976	broad.mit.edu	37	1	3319489	3319489	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:3319489G>C	uc001akf.2	+	6	891	c.811G>C	c.(811-813)GAG>CAG	p.E271Q	PRDM16_uc001akc.2_Missense_Mutation_p.E271Q|PRDM16_uc001akd.2_Missense_Mutation_p.E271Q|PRDM16_uc001ake.2_Missense_Mutation_p.E271Q|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	271					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GCTCAAGCCCGAGGGCCTTGG	0.622		NaN	T	EVI1	MDS|AML								0	0	0	0.010729	0	11	49									
TPRG1L	127262	broad.mit.edu	37	1	3542350	3542350	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:3542350G>A	uc001akm.2	+	3	448	c.367G>A	c.(367-369)GAC>AAC	p.D123N	TPRG1L_uc009vlj.2_Intron	NM_182752	NP_877429	Q5T0D9	TPRGL_HUMAN	tumor protein p63 regulated 1-like	123						cell junction|synaptic vesicle					0	all_cancers(77;0.0119)|all_epithelial(69;0.00481)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.41e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.83e-22)|GBM - Glioblastoma multiforme(42;4.77e-14)|Colorectal(212;1.12e-05)|COAD - Colon adenocarcinoma(227;5.61e-05)|Kidney(185;0.000351)|BRCA - Breast invasive adenocarcinoma(365;0.000688)|KIRC - Kidney renal clear cell carcinoma(229;0.00553)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.201)		CTGTAAATACGACTTCATCAG	0.547		NaN											0	0	0	0.00308	0	8	36									
WDR8	49856	broad.mit.edu	37	1	3547608	3547608	+	Silent	SNP	G	G	A	rs145375547		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:3547608G>A	uc001ako.2	-	12	1422	c.1314C>T	c.(1312-1314)TTC>TTT	p.F438F	WDR8_uc001akn.3_3'UTR	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	WD repeat domain 8	438						centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		AGCAGAGGCAGAAGTGATCCT	0.592		NaN											0	0	0	0.011902	0	44	77									
CHD5	26038	broad.mit.edu	37	1	6195343	6195343	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:6195343G>A	uc001amb.1	-	18	2917	c.2817C>T	c.(2815-2817)AAC>AAT	p.N939N	CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	939					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGGCCGGCATGTTCTTGAACA	0.597		NaN											0	0	0	0.005443	0	27	83									
DNAJC11	55735	broad.mit.edu	37	1	6696217	6696217	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:6696217C>T	uc001aof.2	-	15	1720	c.1614G>A	c.(1612-1614)GTG>GTA	p.V538V	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.V486V|DNAJC11_uc010nzu.1_Silent_p.V448V	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	538					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCACCATCACCTGATGCA	0.597		NaN											0	0	0	0.004656	0	27	36									
RERE	473	broad.mit.edu	37	1	8420690	8420690	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:8420690C>T	uc001ape.2	-	19	3687	c.2877G>A	c.(2875-2877)ATG>ATA	p.M959I	RERE_uc001apf.2_Missense_Mutation_p.M959I|RERE_uc010nzx.1_Missense_Mutation_p.M691I|RERE_uc001apd.2_Missense_Mutation_p.M405I	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	959	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGTTGGCATTCATGGAGAAGG	0.687		NaN											0	0	0	0.00632	0	24	100									
SLC25A33	84275	broad.mit.edu	37	1	9613859	9613859	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:9613859C>T	uc001apw.2	+	2	455	c.232C>T	c.(232-234)CTG>TTG	p.L78L	SLC25A33_uc001apx.2_5'UTR	NM_032315	NP_115691	Q9BSK2	S2533_HUMAN	mitochondrial carrier protein MGC4399	78	Solcar 1.				transport	integral to membrane|mitochondrial inner membrane					0	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CTTTCAGGTTCTGAAGTAAGT	0.493		NaN											0	0	0	0.00308	0	7	44									
RBP7	116362	broad.mit.edu	37	1	10067689	10067689	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:10067689G>A	uc001aqq.2	+	2	197	c.135G>A	c.(133-135)CAG>CAA	p.Q45Q	RBP7_uc009vms.2_RNA	NM_052960	NP_443192	Q96R05	RET7_HUMAN	retinol binding protein 7, cellular	45						cytoplasm	retinal binding|retinol binding|transporter activity				0		all_lung(284;0.000407)|Renal(390;0.000469)|Lung NSC(185;0.000577)|Colorectal(325;0.0062)|Breast(348;0.00686)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|BRCA - Breast invasive adenocarcinoma(304;0.000302)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00856)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	TGATTGAGCAGAATGGGGATT	0.368		NaN											0	0	0	0.008871	0	20	62									
UBE4B	10277	broad.mit.edu	37	1	10195078	10195078	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:10195078T>A	uc001aqs.3	+	16	2771	c.2058T>A	c.(2056-2058)TTT>TTA	p.F686L	UBE4B_uc001aqr.3_Missense_Mutation_p.F557L|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.F141L|UBE4B_uc001aqt.1_Missense_Mutation_p.F26L	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	686					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CAGATGGATTTATGCTGAATT	0.294		NaN											0	0	0	0.012319	0	21	93									
CLCN6	1185	broad.mit.edu	37	1	11882771	11882771	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:11882771G>A	uc001ate.3	+	6	479	c.366G>A	c.(364-366)CAG>CAA	p.Q122Q	CLCN6_uc009vnf.1_Silent_p.Q122Q|CLCN6_uc009vng.1_Silent_p.Q122Q|CLCN6_uc009vnh.1_Silent_p.Q122Q|CLCN6_uc010oat.1_5'UTR|CLCN6_uc010oau.1_Silent_p.Q100Q	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a	122					cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGCAGCCAGAAAGGCTGCC	0.547		NaN											0	0	0	0.007835	0	42	93									
VPS13D	55187	broad.mit.edu	37	1	12304593	12304593	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:12304593G>A	uc001atv.2	+	5	508	c.367_splice	c.e5-1	p.N123_splice	VPS13D_uc001atw.2_Splice_Site_p.N123_splice	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1						protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGTCTTTGTAGAATGACCGCC	0.458		NaN											0	0	0	0.01441	0	68	82									
VPS13D	55187	broad.mit.edu	37	1	12387712	12387712	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:12387712G>A	uc001atv.2	+	36	8139	c.7998G>A	c.(7996-7998)TTG>TTA	p.L2666L	VPS13D_uc001atw.2_Silent_p.L2666L|VPS13D_uc001atx.2_Silent_p.L1854L|VPS13D_uc001aty.1_Silent_p.L404L	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2666	UBA.				protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AAGGCCAATTGAAAAAGGCAG	0.473		NaN											0	0	0	0.01441	0	90	249									
PRDM2	7799	broad.mit.edu	37	1	14105194	14105194	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:14105194G>A	uc001avi.2	+	8	1760	c.904G>A	c.(904-906)GAA>AAA	p.E302K	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.E302K|PRDM2_uc001avj.2_Intron|PRDM2_uc009vod.1_Missense_Mutation_p.E59K|PRDM2_uc001avk.2_Missense_Mutation_p.E101K|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	302	Retinoblastoma protein binding.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		CATGCCAAATGAAAATTCTGT	0.234		NaN											0	0	0	0.008871	0	21	72									
DNAJC16	23341	broad.mit.edu	37	1	15874821	15874821	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:15874821G>C	uc001aws.2	+	7	1041	c.921G>C	c.(919-921)TTG>TTC	p.L307F	DNAJC16_uc001awr.1_Missense_Mutation_p.L307F|DNAJC16_uc001awt.2_5'UTR	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	307	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ATGTGGGTTTGAGAGGGACGG	0.398		NaN											0	0	0	0.003271	0	35	72									
DDI2	84301	broad.mit.edu	37	1	15956939	15956939	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:15956939C>T	uc001awx.1	+	3	484	c.388C>T	c.(388-390)CAG>TAG	p.Q130*	DDI2_uc001aww.2_Nonsense_Mutation_p.Q130*|DDI2_uc009voj.1_5'UTR	NM_032341	NP_115717	Q5TDH0	DDI2_HUMAN	DNA-damage inducible protein 2	130					proteolysis		aspartic-type endopeptidase activity				0		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TTCATCTCCTCAGGGCTTGGA	0.562		NaN											0	0	0	0.014323	0	24	114									
PLEKHM2	23207	broad.mit.edu	37	1	16053943	16053943	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16053943C>T	uc010obo.1	+	9	1603	c.1376C>T	c.(1375-1377)TCA>TTA	p.S459L		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	459					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GAGGGGCTTTCAGCCCCAATG	0.632		NaN											0	0	0	0.009096	0	4	12									
SPEN	23013	broad.mit.edu	37	1	16259146	16259146	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16259146G>A	uc001axk.1	+	11	6615	c.6411G>A	c.(6409-6411)TTG>TTA	p.L2137L	SPEN_uc010obp.1_Silent_p.L2096L	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2137	Interaction with MSX2 (By similarity).				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CATCCCAGTTGAAAAGTGATC	0.557		NaN											0	0	0	0.01441	0	75	153									
SPEN	23013	broad.mit.edu	37	1	16259289	16259289	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16259289C>T	uc001axk.1	+	11	6758	c.6554C>T	c.(6553-6555)TCT>TTT	p.S2185F	SPEN_uc010obp.1_Missense_Mutation_p.S2144F	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2185	Interaction with MSX2 (By similarity).				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCTGAGGCCTCTGCCTCTGCT	0.622		NaN											0	0	0	0.01441	0	57	62									
ZBTB17	7709	broad.mit.edu	37	1	16269163	16269163	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16269163C>T	uc001axl.3	-	14	2138	c.1899G>A	c.(1897-1899)GTG>GTA	p.V633V	ZBTB17_uc010obq.1_Silent_p.V550V|ZBTB17_uc010obr.1_Silent_p.V633V|ZBTB17_uc010obs.1_Silent_p.V557V	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	633	C2H2-type 12.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		GCACGGTCTTCACGTGGGAGC	0.592		NaN											0	0	0	0.013726	0	32	29									
ZBTB17	7709	broad.mit.edu	37	1	16269661	16269661	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:16269661G>A	uc001axl.3	-	13	1965	c.1726C>T	c.(1726-1728)CAT>TAT	p.H576Y	ZBTB17_uc010obq.1_Missense_Mutation_p.H493Y|ZBTB17_uc010obr.1_Missense_Mutation_p.H576Y|ZBTB17_uc010obs.1_Missense_Mutation_p.H500Y	NM_003443	NP_003434	Q13105	ZBT17_HUMAN	zinc finger and BTB domain containing 17	576	C2H2-type 10.				negative regulation of cell cycle	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(325;0.000257)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|Colorectal(212;4.12e-07)|COAD - Colon adenocarcinoma(227;2.43e-05)|BRCA - Breast invasive adenocarcinoma(304;9.97e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TGGCGAATATGATTGGCCAAC	0.587		NaN											0	0	0	0.012213	0	29	128									
CROCC	9696	broad.mit.edu	37	1	17257888	17257888	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:17257888G>A	uc001azt.2	+	8	1021	c.952G>A	c.(952-954)GAG>AAG	p.E318K	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_Missense_Mutation_p.E81K	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	318	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GATGTTCACTGAGAGGTGAGG	0.587		NaN											0	0	0	0.01441	0	79	60									
PADI2	11240	broad.mit.edu	37	1	17409048	17409048	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:17409048C>T	uc001baf.2	-	10	1232	c.1150G>A	c.(1150-1152)GAG>AAG	p.E384K	PADI2_uc010ocm.1_Missense_Mutation_p.E268K|PADI2_uc001bag.1_Missense_Mutation_p.E384K	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	384					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	ACCAGGAGCTCCTTCACAGGG	0.483		NaN											0	0	0	0.012319	0	21	60									
IGSF21	84966	broad.mit.edu	37	1	18661457	18661457	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:18661457G>T	uc001bau.1	+	4	760	c.377G>T	c.(376-378)AGG>ATG	p.R126M		NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	126	Ig-like 1.					extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CGCGCCACCAGGGAGAAGGTG	0.617		NaN											1	0	7.48243e-07	0.006214	7.68791e-07	9	22									
TAS1R2	80834	broad.mit.edu	37	1	19186032	19186032	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:19186032G>C	uc001bba.1	-	1	124	c.123C>G	c.(121-123)CTC>CTG	p.L41L		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	41	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TGTTGGCATGGAGGGAGAAGA	0.582		NaN											0	0	0	0.007835	0	43	45									
UBR4	23352	broad.mit.edu	37	1	19510379	19510379	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:19510379C>T	uc001bbi.2	-	17	2114	c.2110G>A	c.(2110-2112)GAA>AAA	p.E704K		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	704					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCAAACTCTTCATCTGATGAA	0.443		NaN											0	0	0	0.003163	0	15	41									
KIAA0090	23065	broad.mit.edu	37	1	19559255	19559255	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:19559255C>G	uc001bbo.2	-	15	1688	c.1645G>C	c.(1645-1647)GAG>CAG	p.E549Q	KIAA0090_uc001bbp.2_Missense_Mutation_p.E548Q|KIAA0090_uc001bbq.2_Missense_Mutation_p.E548Q|KIAA0090_uc001bbr.2_Missense_Mutation_p.E527Q	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	549	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		GAGCTGCTCTCAATGCCAAAA	0.438		NaN											0	0	0	0.00623	0	38	131									
EIF4G3	8672	broad.mit.edu	37	1	21167472	21167472	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:21167472A>G	uc001bec.2	-	25	4026	c.3770T>C	c.(3769-3771)GTT>GCT	p.V1257A	EIF4G3_uc010odi.1_Missense_Mutation_p.V861A|EIF4G3_uc010odj.1_Missense_Mutation_p.V1256A|EIF4G3_uc009vpz.2_Missense_Mutation_p.V977A|EIF4G3_uc001bed.2_Missense_Mutation_p.V1257A|EIF4G3_uc001bef.2_Missense_Mutation_p.V1293A|EIF4G3_uc001bee.2_Missense_Mutation_p.V1263A	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1257	MI.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCTCACAAAAACATGTAGTAG	0.478		NaN											0	0	0	0.007291	0	29	70									
HSPG2	3339	broad.mit.edu	37	1	22173050	22173050	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:22173050G>A	uc001bfj.2	-	63	8247	c.8207C>T	c.(8206-8208)TCA>TTA	p.S2736L	HSPG2_uc009vqd.2_Missense_Mutation_p.S2737L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2736	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGCCACGTGTGAGGAGGATGA	0.622		NaN											0	0	0	0.006122	0	18	67									
HSPG2	3339	broad.mit.edu	37	1	22173059	22173059	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:22173059G>A	uc001bfj.2	-	63	8238	c.8198C>T	c.(8197-8199)TCA>TTA	p.S2733L	HSPG2_uc009vqd.2_Missense_Mutation_p.S2734L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2733	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TGAGGAGGATGACTCAATTCT	0.627		NaN											0	0	0	0.004007	0	15	60									
HSPG2	3339	broad.mit.edu	37	1	22178312	22178312	+	Silent	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:22178312A>T	uc001bfj.2	-	54	7018	c.6978T>A	c.(6976-6978)ACT>ACA	p.T2326T	HSPG2_uc009vqd.2_Silent_p.T2327T	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2326	Ig-like C2-type 8.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCTGGGTCCCAGTTACTGTGA	0.637		NaN											0	0	0	0.013537	0	12	37									
C1orf213	148898	broad.mit.edu	37	1	23696057	23696057	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:23696057G>A	uc001bgw.2	+	1	594	c.267G>A	c.(265-267)CTG>CTA	p.L89L	ZNF436_uc001bgt.2_5'Flank|ZNF436_uc001bgu.2_5'UTR|C1orf213_uc001bgv.2_Intron	NM_138479	NP_612488			hypothetical protein LOC148898 isoform 1												0		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.97e-26)|Colorectal(126;4.8e-08)|COAD - Colon adenocarcinoma(152;2.83e-06)|GBM - Glioblastoma multiforme(114;5.23e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|KIRC - Kidney renal clear cell carcinoma(1967;0.00314)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0827)|LUSC - Lung squamous cell carcinoma(448;0.184)		ATCGTAGGCTGATCCTAAAGA	0.562		NaN											0	0	0	0.001168	0	5	30									
MYOM3	127294	broad.mit.edu	37	1	24406673	24406673	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:24406673C>T	uc001bin.3	-	20	2582	c.2419G>A	c.(2419-2421)GAT>AAT	p.D807N	MYOM3_uc001bim.3_Missense_Mutation_p.D464N|MYOM3_uc001bio.2_Missense_Mutation_p.D807N	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	807	Fibronectin type-III 5.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GCCCGTACATCGTACGGGGGG	0.453		NaN											0	0	0	0.00499	0	15	33									
NIPAL3	57185	broad.mit.edu	37	1	24768670	24768670	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:24768670C>T	uc001bjh.2	+	4	695	c.288C>T	c.(286-288)TTC>TTT	p.F96F	NIPAL3_uc010oek.1_Silent_p.F96F|NIPAL3_uc001bjg.2_Silent_p.F96F|NIPAL3_uc009vrc.2_Silent_p.F14F	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	96	Helical; (Potential).					integral to membrane					0						CCTACGCCTTCGCGCCGCTGT	0.632		NaN											0	0	0	0.010504	0	19	75									
PAQR7	164091	broad.mit.edu	37	1	26190213	26190213	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:26190213G>A	uc001bkx.2	-	2	785	c.118C>T	c.(118-120)CCG>TCG	p.P40S		NM_178422	NP_848509	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	40	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)	3		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		CAGAAGAGCGGCGGCACCTCA	0.622		NaN											0	0	0	0.00499	0	15	28									
CNKSR1	10256	broad.mit.edu	37	1	26509694	26509694	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:26509694G>A	uc001bln.3	+	7	689	c.631G>A	c.(631-633)GAA>AAA	p.E211K	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.E211K|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	211	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGGGCCTAGAAATTCACAC	0.627		NaN											0	0	0	0.01441	0	105	117									
PIGV	55650	broad.mit.edu	37	1	27121287	27121287	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27121287C>T	uc001bmz.2	+	3	1093	c.762C>T	c.(760-762)CTC>CTT	p.L254L	PIGV_uc001bmy.2_Intron|PIGV_uc009vso.2_Silent_p.L254L|PIGV_uc010ofg.1_Intron|PIGV_uc001bna.2_Silent_p.L254L	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	254	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		CCTTTGCCCTCTTTCAGTATT	0.502		NaN											0	0	0	0.01441	0	46	130									
PIGV	55650	broad.mit.edu	37	1	27124267	27124267	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27124267C>T	uc001bmz.2	+	4	1745	c.1414C>T	c.(1414-1416)CTA>TTA	p.L472L	PIGV_uc001bmy.2_Silent_p.L237L|PIGV_uc009vso.2_Missense_Mutation_p.S465F|PIGV_uc010ofg.1_Silent_p.L237L|PIGV_uc001bna.2_Silent_p.L472L	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	472	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		ACGATACATTCTAGGCTACTT	0.502		NaN											0	0	0	0.012319	0	19	62									
FCN3	8547	broad.mit.edu	37	1	27700864	27700864	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27700864C>A	uc001boa.2	-	2	176	c.170G>T	c.(169-171)GGA>GTA	p.G57V	FCN3_uc001bob.2_Missense_Mutation_p.G57V	NM_003665	NP_003656	O75636	FCN3_HUMAN	ficolin 3 isoform 1 precursor	57	Collagen-like.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding				0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		ACCTGGGGCTCCCTTCTCCCC	0.612		NaN											1	0	0.00010058	0.013537	0.000102565	11	29									
AHDC1	27245	broad.mit.edu	37	1	27875316	27875316	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27875316C>A	uc009vsy.2	-	6	4280	c.3311G>T	c.(3310-3312)GGG>GTG	p.G1104V	AHDC1_uc009vsz.1_Missense_Mutation_p.G1104V	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1104							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CTGAGAAGCCCCCGCAAACTG	0.567		NaN											1	0	3.86212e-05	0.008291	3.94205e-05	10	49									
FGR	2268	broad.mit.edu	37	1	27939500	27939500	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27939500G>C	uc001boj.2	-	11	1661	c.1515C>G	c.(1513-1515)TTC>TTG	p.F505L	FGR_uc001boi.2_Missense_Mutation_p.F208L|FGR_uc001bok.2_Missense_Mutation_p.F505L|FGR_uc001bol.2_Missense_Mutation_p.F505L|FGR_uc001bom.2_Missense_Mutation_p.F505L	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	505	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GCAGGTACTCGAAGGTAGGCC	0.622		NaN											0	0	0	0.004482	0	8	36									
FGR	2268	broad.mit.edu	37	1	27950343	27950343	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27950343C>T	uc001boj.2	-	1	231	c.85G>A	c.(85-87)GGG>AGG	p.G29R	FGR_uc001bok.2_Missense_Mutation_p.G29R|FGR_uc001bol.2_Missense_Mutation_p.G29R|FGR_uc001bom.2_Missense_Mutation_p.G29R	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	29					platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGCTGCCCCGTAGCTTCTG	0.587		NaN											0	0	0	0.010729	0	12	26									
FGR	2268	broad.mit.edu	37	1	27950351	27950351	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:27950351C>A	uc001boj.2	-	1	223	c.77G>T	c.(76-78)AGA>ATA	p.R26I	FGR_uc001bok.2_Missense_Mutation_p.R26I|FGR_uc001bol.2_Missense_Mutation_p.R26I|FGR_uc001bom.2_Missense_Mutation_p.R26I	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	26					platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CCCGTAGCTTCTGAAGTCCCC	0.587		NaN											1	0	4.3838e-07	0.001855	4.5106e-07	13	25									
C1orf38	9473	broad.mit.edu	37	1	28206495	28206495	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:28206495C>T	uc001bpc.3	+	3	604	c.576C>T	c.(574-576)CTC>CTT	p.L192L	C1orf38_uc001boz.2_Silent_p.L192L|C1orf38_uc001bpa.2_Intron|C1orf38_uc010ofn.1_Intron|C1orf38_uc010ofo.1_Silent_p.L192L	NM_001105556	NP_001099026	Q5TEJ8	THMS2_HUMAN	basement membrane-induced gene isoform 3	192	CABIT 1.				cell adhesion|inflammatory response					ovary(1)	1		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;2.52e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTCGTCCTCACCTGCCCCA	0.617		NaN											0	0	0	0.009096	0	4	8									
RAB42	115273	broad.mit.edu	37	1	28920495	28920495	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:28920495G>A	uc001bqu.2	+	2	490	c.184G>A	c.(184-186)GAT>AAT	p.D62N	RAB42_uc001bqv.2_Missense_Mutation_p.D62N	NM_152304	NP_689517	Q8N4Z0	RAB42_HUMAN	RAB42, member RAS oncogene family	62					small GTPase mediated signal transduction	membrane	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00618)|all_lung(284;0.00909)|Breast(348;0.0249)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0577)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00298)|KIRC - Kidney renal clear cell carcinoma(1967;0.00948)|BRCA - Breast invasive adenocarcinoma(304;0.0213)|READ - Rectum adenocarcinoma(331;0.0649)		CACCCTCGCTGATGCTATCCA	0.617		NaN											0	0	0	0.014323	0	23	11									
SPOCD1	90853	broad.mit.edu	37	1	32279666	32279666	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:32279666C>G	uc001bts.1	-	2	1327	c.1269G>C	c.(1267-1269)AAG>AAC	p.K423N	SPOCD1_uc001btu.2_Missense_Mutation_p.K423N|SPOCD1_uc001btv.2_Intron	NM_144569	NP_653170	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	423					transcription, DNA-dependent					ovary(5)|breast(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TCTTCAGGTTCTTAGTGCCCT	0.622		NaN											0	0	0	0.010818	0	30	37									
CCDC28B	79140	broad.mit.edu	37	1	32670814	32670814	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:32670814G>A	uc001bul.1	+	6	700	c.568G>A	c.(568-570)GAG>AAG	p.E190K	CCDC28B_uc001buk.2_3'UTR|IQCC_uc001bum.2_5'Flank|IQCC_uc009vua.2_5'Flank|IQCC_uc010ogz.1_5'Flank	NM_024296	NP_077272	Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	190											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCACCTGGCCGAGAACGCCGA	0.607		NaN											0	0	0	0.009096	0	4	16									
YARS	8565	broad.mit.edu	37	1	33245125	33245125	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:33245125C>T	uc001bvy.1	-	12	2123	c.1335_splice	c.e12-1	p.I445_splice	YARS_uc001bvw.1_Splice_Site_p.I105_splice|YARS_uc001bvx.1_Splice_Site_p.I96_splice	NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase						apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TATCCCTTCTCTGGGAAGACA	0.562		NaN											0	0	0	0.007413	0	20	47									
YARS	8565	broad.mit.edu	37	1	33252626	33252626	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:33252626C>T	uc001bvy.1	-	7	1523	c.735G>A	c.(733-735)CTG>CTA	p.L245L		NM_003680	NP_003671	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	245					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	AGGCCTTCTTCAGTTTTTTCT	0.443		NaN											0	0	0	0.01441	0	57	45									
ZMYM6	9204	broad.mit.edu	37	1	35476590	35476590	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:35476590C>T	uc001byh.2	-	9	1338	c.1110G>A	c.(1108-1110)CTG>CTA	p.L370L	ZMYM6_uc001byf.1_Silent_p.L370L|ZMYM6_uc010oht.1_Silent_p.L273L|ZMYM6_uc009vup.2_Silent_p.L176L|ZMYM6_uc009vuq.1_Silent_p.L370L|ZMYM6_uc009vur.1_Silent_p.L176L	NM_007167	NP_009098	O95789	ZMYM6_HUMAN	zinc finger protein 258	370	MYM-type 5.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GGCCCTGAGACAGGGGCACCG	0.478		NaN											0	0	0	0.008871	0	17	51									
ZMYM1	79830	broad.mit.edu	37	1	35575944	35575944	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:35575944C>T	uc001bym.2	+	8	1005	c.857C>T	c.(856-858)TCA>TTA	p.S286L	ZMYM1_uc001byn.2_Missense_Mutation_p.S286L|ZMYM1_uc010ohu.1_Missense_Mutation_p.S286L|ZMYM1_uc001byo.2_5'UTR|ZMYM1_uc009vut.2_Missense_Mutation_p.S211L	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	286						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTGAAGCCCTCAGATGAAATG	0.353		NaN											0	0	0	0.012213	0	34	118									
KIAA0319L	79932	broad.mit.edu	37	1	35972601	35972601	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:35972601G>C	uc001byx.2	-	3	536	c.278C>G	c.(277-279)TCT>TGT	p.S93C	KIAA0319L_uc010ohw.1_RNA|KIAA0319L_uc001byz.2_Missense_Mutation_p.S93C|KIAA0319L_uc010ohx.1_Missense_Mutation_p.S93C	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	93	MANSC.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATGGCAGGCAGAGTCCTGGCA	0.562		NaN											0	0	0	0.010729	0	7	29									
C1orf216	127703	broad.mit.edu	37	1	36181317	36181317	+	Silent	SNP	G	G	A	rs11554216		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:36181317G>A	uc001bzh.1	-	2	1094	c.606C>T	c.(604-606)TTC>TTT	p.F202F		NM_152374	NP_689587	Q8TAB5	CA216_HUMAN	hypothetical protein LOC127703	202										skin(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				GGATGGTGTCGAAGCTCTCCT	0.607		NaN									OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.012213	0	31	90									
MAP7D1	55700	broad.mit.edu	37	1	36643602	36643602	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:36643602C>A	uc001bzz.2	+	9	1724	c.1508C>A	c.(1507-1509)TCC>TAC	p.S503Y	MAP7D1_uc001caa.2_Missense_Mutation_p.S471Y|MAP7D1_uc001cab.2_Missense_Mutation_p.S466Y|MAP7D1_uc001cac.2_Missense_Mutation_p.S203Y|MAP7D1_uc001cad.2_Missense_Mutation_p.S49Y	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	503	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				ACCACTGCATCCCCCAAGGGG	0.701		NaN											1	0	0.00116845	0.001168	0.00118816	5	22									
RHBDL2	54933	broad.mit.edu	37	1	39352269	39352269	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:39352269C>T	uc001ccu.1	-	8	1047	c.819G>A	c.(817-819)CTG>CTA	p.L273L	RHBDL2_uc010oin.1_3'UTR|RHBDL2_uc010oio.1_Silent_p.L353L	NM_017821	NP_060291	Q9NX52	RHBL2_HUMAN	rhomboid protease 2	273					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity				0	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			TTGGATCTTTCAGCAGTGCTT	0.433		NaN											0	0	0	0.00632	0	28	94									
MACF1	23499	broad.mit.edu	37	1	39757669	39757669	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:39757669G>A	uc010ois.1	+	17	2093	c.1888G>A	c.(1888-1890)GAA>AAA	p.E630K	MACF1_uc001cda.1_Missense_Mutation_p.E538K	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	630					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TACGAGTGTAGAAGAGCTGGG	0.507		NaN											0	0	0	0.003954	0	27	30									
MACF1	23499	broad.mit.edu	37	1	39919397	39919397	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:39919397G>C	uc010oiu.1	+	53	16221	c.16090G>C	c.(16090-16092)GAA>CAA	p.E5364Q	MACF1_uc010ois.1_Missense_Mutation_p.E4862Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAAGAAAGTAGAAGAAAAGCG	0.413		NaN											0	0	0	0.01441	0	92	84									
MACF1	23499	broad.mit.edu	37	1	39950348	39950348	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:39950348G>A	uc010oiu.1	+	63	17637	c.17506G>A	c.(17506-17508)GAT>AAT	p.D5836N	MACF1_uc010ois.1_Missense_Mutation_p.D5328N|MACF1_uc001cde.1_Missense_Mutation_p.D242N|MACF1_uc001cdf.1_Missense_Mutation_p.D211N|MACF1_uc001cdg.2_Missense_Mutation_p.D156N|MACF1_uc001cdh.2_Missense_Mutation_p.D119N	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	7286	Ser-rich.|C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CCTTGCTGGTGATACCAGCAA	0.458		NaN											0	0	0	0.007835	0	39	145									
PABPC4	8761	broad.mit.edu	37	1	40041525	40041525	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:40041525G>A	uc010oiv.1	-	1	997	c.99C>T	c.(97-99)CCC>CCT	p.P33P	PABPC4_uc001cdl.2_Silent_p.P33P|PABPC4_uc001cdm.2_Silent_p.P33P	NM_003819	NP_003810	Q13310	PABP4_HUMAN	poly A binding protein, cytoplasmic 4 isoform 2	33	RRM 1.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding				0	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAGGCCCCGCGGGGCTGAACT	0.647		NaN											0	0	0	0.001984	0	6	17									
ZNF643	65243	broad.mit.edu	37	1	40929203	40929203	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:40929203C>T	uc001cfn.1	+	5	1844	c.1547C>T	c.(1546-1548)TCA>TTA	p.S516L	ZNF643_uc001cfl.1_Missense_Mutation_p.S414L|ZNF643_uc001cfm.1_Missense_Mutation_p.S382L	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	516	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			AGCTGTAGTTCATCCCTTATT	0.353		NaN											0	0	0	0.010504	0	20	73									
KCNQ4	9132	broad.mit.edu	37	1	41283961	41283961	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:41283961C>T	uc001cgh.1	+	3	613	c.531C>T	c.(529-531)ATC>ATT	p.I177I	KCNQ4_uc001cgi.1_Silent_p.I177I	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	177	Helical; Name=Segment S3; (Potential).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TCTGTGTCATCGGTAATGAGG	0.647		NaN											0	0	0	0.003755	0	35	41									
EDN2	1907	broad.mit.edu	37	1	41949827	41949827	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:41949827G>A	uc001cgx.2	-	2	184	c.112C>T	c.(112-114)CAT>TAT	p.H38Y	EDN2_uc001cgu.2_RNA|EDN2_uc001cgv.2_RNA|EDN2_uc009vwh.2_5'UTR|EDN2_uc001cgw.2_RNA|EDN2_uc009vwi.2_RNA|EDN2_uc009vwj.2_RNA	NM_001956	NP_001947	P20800	EDN2_HUMAN	endothelin 2 preproprotein	38					artery smooth muscle contraction|calcium-mediated signaling|cytokine-mediated signaling pathway|elevation of cytosolic calcium ion concentration|hormonal regulation of the force of heart contraction|inositol phosphate-mediated signaling|macrophage activation|macrophage chemotaxis|neutrophil chemotaxis|positive regulation of cell proliferation|positive regulation of heart rate|positive regulation of leukocyte chemotaxis|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of the force of heart contraction by chemical signal|prostaglandin biosynthetic process|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space	endothelin B receptor binding|hormone activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTTGGGCATGAGATGAGGAC	0.627		NaN											0	0	0	0.013537	0	12	22									
FOXJ3	22887	broad.mit.edu	37	1	42647606	42647606	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:42647606G>C	uc001che.2	-	14	2047	c.1735C>G	c.(1735-1737)CCA>GCA	p.P579A	FOXJ3_uc001chf.2_Missense_Mutation_p.P579A|FOXJ3_uc001chg.2_Missense_Mutation_p.P579A	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	579					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GTTGTTCCTGGAGTGCTGAGT	0.403		NaN											0	0	0	0.001984	0	7	25									
FOXJ3	22887	broad.mit.edu	37	1	42671497	42671497	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:42671497C>T	uc001che.2	-	8	878	c.566G>A	c.(565-567)GGA>GAA	p.G189E	FOXJ3_uc001chf.2_Missense_Mutation_p.G189E|FOXJ3_uc001chg.2_Missense_Mutation_p.G189E|FOXJ3_uc001chh.1_Intron	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	189					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ACACTCCATTCCCAAAGAATC	0.318		NaN											0	0	0	0.004289	0	33	38									
ZMYND12	84217	broad.mit.edu	37	1	42921666	42921666	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:42921666C>T	uc001chj.2	-	1	273	c.3G>A	c.(1-3)ATG>ATA	p.M1I	ZMYND12_uc010ojt.1_5'UTR|PPCS_uc001chk.2_5'Flank|PPCS_uc001chl.2_5'Flank	NM_032257	NP_115633	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12 isoform 1	1						intracellular	zinc ion binding			ovary(1)	1	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGATCACATTCATGGTGCAGC	0.637		NaN											0	0	0	0.009096	0	4	16									
LEPRE1	64175	broad.mit.edu	37	1	43213045	43213045	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:43213045G>A	uc001chv.2	-	14	2066	c.1953C>T	c.(1951-1953)TTC>TTT	p.F651F	LEPRE1_uc001chw.2_Silent_p.F651F|LEPRE1_uc001chx.3_Silent_p.F651F	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	651	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGCCTGAAGAGAATCCCACGG	0.592		NaN									OREG0013422	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	20	50									
PTPRF	5792	broad.mit.edu	37	1	44019601	44019601	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:44019601C>T	uc001cjr.2	+	5	708	c.368C>T	c.(367-369)TCA>TTA	p.S123L	PTPRF_uc001cjq.3_Missense_Mutation_p.S123L|PTPRF_uc001cjs.2_Missense_Mutation_p.S123L|PTPRF_uc001cjt.3_Missense_Mutation_p.S123L	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	123	Extracellular (Potential).|Ig-like C2-type 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.G123E(1)		ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCCAAGCTCTCAGTGCTCGAA	0.602		NaN											0	0	0	0.013537	0	12	19									
SLC6A9	6536	broad.mit.edu	37	1	44477385	44477385	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:44477385G>A	uc001cll.2	-	2	289	c.97C>T	c.(97-99)CTC>TTC	p.L33F	SLC6A9_uc009vxe.2_Intron|SLC6A9_uc010okm.1_Intron|SLC6A9_uc001clm.2_Intron|SLC6A9_uc009vxd.2_Intron|SLC6A9_uc010okn.1_Intron|SLC6A9_uc001cln.2_Intron|SLC6A9_uc010oko.1_Intron|SLC6A9_uc010okp.1_Intron	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	33	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	TGAACAGGGAGAAGCGTCACC	0.602		NaN											0	0	0	0.00245	0	14	48									
BEST4	266675	broad.mit.edu	37	1	45251772	45251772	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:45251772C>T	uc001cmm.2	-	4	659	c.610G>A	c.(610-612)GAT>AAT	p.D204N		NM_153274	NP_695006	Q8NFU0	BEST4_HUMAN	bestrophin 4	204	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					AGAGCGATATCGTCACGTATT	0.502		NaN									OREG0013447	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	72	89									
PLK3	1263	broad.mit.edu	37	1	45266717	45266717	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:45266717G>A	uc001cmn.2	+	3	428	c.328G>A	c.(328-330)GAG>AAG	p.E110K	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	110	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					GATCCTAAATGAGATTGAGCT	0.587		NaN											0	0	0	0.006214	0	10	15									
NASP	4678	broad.mit.edu	37	1	46073665	46073665	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:46073665C>T	uc001coi.1	+	6	1184	c.1082C>T	c.(1081-1083)TCA>TTA	p.S361L	NASP_uc010olq.1_Missense_Mutation_p.S324L|NASP_uc001coh.1_Missense_Mutation_p.S363L|NASP_uc001coj.1_Intron|NASP_uc010olr.1_Missense_Mutation_p.S297L|NASP_uc001cok.1_Missense_Mutation_p.S244L	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	361	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GAGGCTGGATCAGAAGTCTCT	0.527		NaN											0	0	0	0.008291	0	7	80									
IPP	3652	broad.mit.edu	37	1	46211827	46211827	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:46211827C>A	uc001cou.2	-	2	524	c.257G>T	c.(256-258)GGA>GTA	p.G86V	IPP_uc001cos.3_Missense_Mutation_p.G86V	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	86	BTB.					actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CTGAAAGATTCCTGCTTCAAT	0.358		NaN											1	0	5.03518e-11	0.007413	5.25558e-11	19	55									
MKNK1	8569	broad.mit.edu	37	1	47024307	47024307	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:47024307C>T	uc001cqb.2	-	14	1582	c.1338G>A	c.(1336-1338)CGG>CGA	p.R446R	MKNK1_uc010omd.1_Silent_p.R310R|MKNK1_uc001cqc.2_Silent_p.R405R|MKNK1_uc009vyi.2_3'UTR|MKNK1_uc010ome.1_3'UTR	NM_003684	NP_003675	Q9BUB5	MKNK1_HUMAN	MAP kinase-interacting serine/threonine kinase 1	446					intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)					GGGCCCGTCTCCGGGCCAGGC	0.627		NaN											0	0	0	0.00333	0	23	27									
CYP4Z1	199974	broad.mit.edu	37	1	47564903	47564903	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:47564903G>A	uc001cqu.1	+	8	1017	c.1014G>A	c.(1012-1014)CAG>CAA	p.Q338Q		NM_178134	NP_835235	Q86W10	CP4Z1_HUMAN	cytochrome P450 4Z1	338	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			skin(1)	1						AGCATCAGCAGAGATGCCGAG	0.453		NaN											0	0	0	0.00333	0	24	60									
NRD1	4898	broad.mit.edu	37	1	52344197	52344197	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:52344197C>T	uc001ctc.3	-	1	413	c.91G>A	c.(91-93)GAA>AAA	p.E31K	NRD1_uc001ctd.3_Missense_Mutation_p.E31K|NRD1_uc001cte.2_5'Flank|NRD1_uc001ctf.2_Missense_Mutation_p.E31K|NRD1_uc010ong.1_Intron|NRD1_uc009vzc.1_5'Flank	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	31					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						CCCCGCGTTTCGATTCCCCAG	0.612		NaN											0	0	0	0.001168	0	6	23									
ZFYVE9	9372	broad.mit.edu	37	1	52805846	52805846	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:52805846G>A	uc001cto.2	+	17	4054	c.3882G>A	c.(3880-3882)GTG>GTA	p.V1294V	ZFYVE9_uc001ctp.2_Silent_p.V1235V	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	1294					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TAACAAATGTGAAGATATTCC	0.383		NaN											0	0	0	0.007413	0	19	71									
LRRC42	115353	broad.mit.edu	37	1	54428058	54428058	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:54428058C>T	uc001cwj.1	+	6	1103	c.903C>T	c.(901-903)TGC>TGT	p.C301C	LRRC42_uc001cwl.1_Silent_p.C301C|LRRC42_uc001cwk.1_Silent_p.C301C|LRRC42_uc009vzm.1_Silent_p.C301C	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	301											0						ATAGTAACTGCAAGACAGAGG	0.453		NaN											0	0	0	0.001168	0	6	24									
DHCR24	1718	broad.mit.edu	37	1	55352603	55352603	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:55352603G>A	uc001cyc.1	-	1	319	c.190C>T	c.(190-192)CCG>TCG	p.P64S	DHCR24_uc010ook.1_5'Flank	NM_014762	NP_055577	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase precursor	64	FAD-binding PCMH-type.				anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			pancreas(1)	1						TGCAGGCGCGGAGCGCTGCTG	0.682		NaN											0	0	0	0.000602	0	5	11									
DHCR24	1718	broad.mit.edu	37	1	55352654	55352654	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:55352654C>T	uc001cyc.1	-	1	268	c.139G>A	c.(139-141)GAT>AAT	p.D47N	DHCR24_uc010ook.1_5'Flank	NM_014762	NP_055577	Q15392	DHC24_HUMAN	24-dehydrocholesterol reductase precursor	47	Helical; (Potential).				anti-apoptosis|apoptosis|cell cycle arrest|cholesterol biosynthetic process|negative regulation of caspase activity|neuroprotection|response to oxidative stress|skin development	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	delta24-sterol reductase activity|enzyme binding|flavin adenine dinucleotide binding|peptide antigen binding			pancreas(1)	1						TAGTAGATATCGAAGATAAGC	0.632		NaN											0	0	0	0.004482	0	6	14									
C8A	731	broad.mit.edu	37	1	57320598	57320598	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:57320598C>T	uc001cyo.2	+	1	156	c.24C>T	c.(22-24)ATC>ATT	p.I8I		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	8					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TTTTCTTCATCTTGTCTTTGA	0.433		NaN											0	0	0	0.00245	0	14	13									
DOCK7	85440	broad.mit.edu	37	1	63113920	63113920	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:63113920C>G	uc001daq.2	-	6	623	c.589G>C	c.(589-591)GAC>CAC	p.D197H	DOCK7_uc001dan.2_Missense_Mutation_p.D89H|DOCK7_uc001dao.2_Missense_Mutation_p.D89H|DOCK7_uc001dap.2_Missense_Mutation_p.D197H|DOCK7_uc009wah.1_Missense_Mutation_p.D197H	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	197					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						TTTTTCAAGTCAAAGATACTA	0.363		NaN											0	0	0	0.014323	0	24	82									
ITGB3BP	23421	broad.mit.edu	37	1	63920112	63920112	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:63920112G>A	uc001dba.1	-	6	397	c.366C>T	c.(364-366)CTC>CTT	p.L122L	ITGB3BP_uc001dbb.1_Silent_p.L161L|ITGB3BP_uc001dbc.1_RNA|ITGB3BP_uc001dbd.1_RNA|ITGB3BP_uc009wak.1_Silent_p.L144L|ITGB3BP_uc001dbe.1_Silent_p.L35L	NM_014288	NP_055103	Q13352	CENPR_HUMAN	integrin beta 3 binding protein	122					apoptosis|cell adhesion|CenH3-containing nucleosome assembly at centromere|induction of apoptosis by extracellular signals|mitotic prometaphase|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome, centromeric region|cytosol|membrane fraction|nucleoplasm	protein C-terminus binding|signal transducer activity				0						AGATTCCAATGAGATTTTCAA	0.343		NaN											0	0	0	0.00245	0	15	53									
ROR1	4919	broad.mit.edu	37	1	64643416	64643416	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:64643416C>T	uc001dbj.2	+	9	2091	c.1692C>T	c.(1690-1692)CTC>CTT	p.L564L	uc001dbm.2_5'Flank	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	564	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						ATGAGTTCCTCATCATGAGAT	0.483		NaN											0	0	0	0.00623	0	39	42									
WDR78	79819	broad.mit.edu	37	1	67299731	67299731	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:67299731T>A	uc001dcx.2	-	12	1890	c.1834A>T	c.(1834-1836)ATA>TTA	p.I612L	WDR78_uc009waw.2_Missense_Mutation_p.I358L|WDR78_uc009wax.2_RNA	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1	612	WD 2.									ovary(2)	2						TCTGCTGATATAGAAACTAGT	0.363		NaN											0	0	0	0.00632	0	29	67									
C1orf141	400757	broad.mit.edu	37	1	67559011	67559011	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:67559011C>G	uc001ddl.1	-	7	991	c.880G>C	c.(880-882)GAT>CAT	p.D294H	C1orf141_uc001ddm.1_Missense_Mutation_p.D294H|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	294										ovary(1)	1						AGTTTATCATCTACAGTTGTG	0.333		NaN											0	0	0	0.012213	0	34	118									
PTGER3	5733	broad.mit.edu	37	1	71512801	71512801	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:71512801C>T	uc001dfg.1	-	1	691	c.460G>A	c.(460-462)GAG>AAG	p.E154K	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Missense_Mutation_p.E154K|PTGER3_uc001dfl.1_Missense_Mutation_p.E154K|PTGER3_uc009wbm.1_Missense_Mutation_p.E154K|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Missense_Mutation_p.E154K|PTGER3_uc009wbn.1_Missense_Mutation_p.E154K|PTGER3_uc009wbo.2_Missense_Mutation_p.E154K|PTGER3_uc001dfo.2_Missense_Mutation_p.E154K|PTGER3_uc001dfp.1_Missense_Mutation_p.E154K|PTGER3_uc001dfq.2_Missense_Mutation_p.E154K|uc001dfr.2_RNA	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	154	Cytoplasmic (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	AGCGCCCGCTCGACGGCCATG	0.677		NaN											0	0	0	0.006214	0	9	4									
ELTD1	64123	broad.mit.edu	37	1	79385973	79385973	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:79385973G>A	uc001diq.3	-	10	1512	c.1356C>T	c.(1354-1356)TTC>TTT	p.F452F		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	452	Helical; Name=1; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GAATTTCACTGAAGAACCAGA	0.323		NaN											0	0	0	0.003954	0	25	74									
LPHN2	23266	broad.mit.edu	37	1	82417698	82417698	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:82417698G>C	uc001dit.3	+	9	1835	c.1654G>C	c.(1654-1656)GGG>CGG	p.G552R	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.G552R|LPHN2_uc001div.2_Missense_Mutation_p.G552R|LPHN2_uc009wcd.2_Missense_Mutation_p.G552R|LPHN2_uc001diw.2_Missense_Mutation_p.G123R	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	552	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ACATACCAAAGGGCCAGTGTT	0.398		NaN											0	0	0	0.00632	0	30	40									
CLCA4	22802	broad.mit.edu	37	1	87029391	87029391	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:87029391G>C	uc009wcs.2	+	4	540	c.496G>C	c.(496-498)GAT>CAT	p.D166H	CLCA4_uc009wct.2_Intron|CLCA4_uc009wcu.2_Intron	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	166						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GGGAGTGTTTGATGAGTACAA	0.408		NaN											0	0	0	0.006122	0	17	52									
GBP3	2635	broad.mit.edu	37	1	89477538	89477538	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:89477538G>A	uc001dmt.2	-	7	1246	c.1041C>T	c.(1039-1041)ACC>ACT	p.T347T	GBP3_uc010oss.1_Silent_p.T268T|GBP3_uc001dmu.2_Silent_p.T213T|GBP3_uc001dmv.2_Intron	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	347						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		GCTCCTGGAGGGTTTCTGCGG	0.537		NaN											0	0	0	0.000602	0	5	54									
GFI1	2672	broad.mit.edu	37	1	92941706	92941706	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:92941706G>A	uc001dou.3	-	7	1313	c.1149C>T	c.(1147-1149)CTC>CTT	p.L383L	GFI1_uc001dov.3_Silent_p.L383L|GFI1_uc001dow.3_Silent_p.L383L	NM_001127215	NP_001120687	Q99684	GFI1_HUMAN	growth factor independent 1	383	C2H2-type 5.				negative regulation of calcidiol 1-monooxygenase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1/S phase of mitotic cell cycle|transcription, DNA-dependent|viral reproduction	nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)	1		all_lung(203;0.00292)|Lung NSC(277;0.0115)|all_neural(321;0.185)|Glioma(108;0.203)		OV - Ovarian serous cystadenocarcinoma(397;9.04e-07)|Epithelial(280;1.17e-05)|all cancers(265;5.61e-05)|GBM - Glioblastoma multiforme(16;0.0191)		TGTGGGTGATGAGGTTGGAGC	0.597		NaN											0	0	0	0.00308	0	6	10									
EVI5	7813	broad.mit.edu	37	1	93170239	93170239	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:93170239G>A	uc001dox.2	-	3	354	c.344C>T	c.(343-345)TCT>TTT	p.S115F	EVI5_uc010otf.1_Missense_Mutation_p.S115F	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	115	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		CACAAGAGAAGAGCCACTGTT	0.363		NaN											0	0	0	0.010818	0	33	96									
BCAR3	8412	broad.mit.edu	37	1	94033313	94033313	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:94033313G>A	uc001dpz.2	-	10	2345	c.2070C>T	c.(2068-2070)CTC>CTT	p.L690L	BCAR3_uc001dqa.2_Silent_p.L690L|BCAR3_uc001dqb.2_Silent_p.L690L|BCAR3_uc001dpx.3_Silent_p.L366L|BCAR3_uc001dpy.2_Silent_p.L599L	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	690	Ras-GEF.				response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CTTCATGCAGGAGTTTGCTGA	0.547		NaN											0	0	0	0.00333	0	26	62									
BCAR3	8412	broad.mit.edu	37	1	94048275	94048275	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:94048275G>A	uc001dpz.2	-	7	1544	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	BCAR3_uc001dqa.2_Silent_p.L423L|BCAR3_uc001dqb.2_Silent_p.L423L|BCAR3_uc001dpx.3_Silent_p.L99L|BCAR3_uc001dpy.2_Silent_p.L332L|BCAR3_uc009wdm.1_Silent_p.L99L	NM_003567	NP_003558	O75815	BCAR3_HUMAN	breast cancer antiestrogen resistance 3	423					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CCTCTGAGTTGAGCCAGGCAG	0.607		NaN											0	0	0	0.008871	0	20	47									
GCLM	2730	broad.mit.edu	37	1	94370097	94370097	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:94370097G>A	uc001dqg.1	-	2	467	c.174C>T	c.(172-174)ATC>ATT	p.I58I		NM_002061	NP_002052	P48507	GSH0_HUMAN	glutamate-cysteine ligase regulatory protein	58					glutamate metabolic process|glutathione biosynthetic process|regulation of blood vessel size|response to drug|response to oxidative stress|xenobiotic metabolic process	cytosol|soluble fraction	glutamate-cysteine ligase catalytic subunit binding			ovary(1)	1		all_lung(203;0.000815)|Lung NSC(277;0.00363)		all cancers(265;0.00566)|GBM - Glioblastoma multiforme(16;0.0203)|Epithelial(280;0.131)	L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	AATCTGGGTTGATTTGGGAAC	0.338		NaN											0	0	0	0.007413	0	16	79									
SNX7	51375	broad.mit.edu	37	1	99157196	99157196	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:99157196G>A	uc010ouc.1	+	4	632	c.580G>A	c.(580-582)GAT>AAT	p.D194N	SNX7_uc001dsa.2_Missense_Mutation_p.D130N|SNX7_uc010oud.1_Intron	NM_015976	NP_057060	Q9UNH6	SNX7_HUMAN	sorting nexin 7 isoform a	130	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		CCGAATTGCTGATCATCCAAC	0.338		NaN											0	0	0	0.013537	0	11	52									
AGL	178	broad.mit.edu	37	1	100327239	100327239	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:100327239C>A	uc001dsi.1	+	3	663	c.263C>A	c.(262-264)TCT>TAT	p.S88Y	AGL_uc001dsj.1_Missense_Mutation_p.S88Y|AGL_uc001dsk.1_Missense_Mutation_p.S88Y|AGL_uc001dsl.1_Missense_Mutation_p.S88Y|AGL_uc001dsm.1_Missense_Mutation_p.S72Y|AGL_uc001dsn.1_Missense_Mutation_p.S71Y	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	88	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CTGCAACAATCTGGTTCATTT	0.313		NaN											1	0	5.35356e-11	0.00278	5.5852e-11	23	101									
PRMT6	55170	broad.mit.edu	37	1	107600219	107600219	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:107600219G>A	uc010ous.1	+	1	953	c.882G>A	c.(880-882)GTG>GTA	p.V294V		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	294					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity				0		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		GGTTCCAGGTGACCTTCCCTG	0.652		NaN											0	0	0	0.008871	0	20	10									
FAM102B	284611	broad.mit.edu	37	1	109171130	109171130	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:109171130G>A	uc010ouy.1	+	8	846	c.766G>A	c.(766-768)GAA>AAA	p.E256K		NM_001010883	NP_001010883	Q5T8I3	F102B_HUMAN	hypothetical protein LOC284611	256										large_intestine(1)	1		all_epithelial(167;5.52e-05)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0217)|Lung(183;0.109)|COAD - Colon adenocarcinoma(174;0.141)|Epithelial(280;0.182)		GCCATGTGATGAAATTGAGCA	0.408		NaN											0	0	0	0.010818	0	30	83									
SARS	6301	broad.mit.edu	37	1	109756738	109756738	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:109756738G>C	uc001dwu.1	+	1	199	c.124G>C	c.(124-126)GAG>CAG	p.E42Q	SARS_uc001dwt.1_Missense_Mutation_p.E42Q|SARS_uc001dwv.1_Missense_Mutation_p.E42Q|SARS_uc001dww.1_5'UTR|SARS_uc001dwx.1_Missense_Mutation_p.E42Q|SARS_uc009wfa.1_Missense_Mutation_p.E42Q|SARS_uc001dwy.1_5'UTR	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	42					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	GGCAGACAGCGAGTGGCGACG	0.587		NaN											0	0	0	0.00308	0	6	21									
GNAI3	2773	broad.mit.edu	37	1	110129467	110129467	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:110129467G>C	uc001dxz.2	+	7	994	c.837G>C	c.(835-837)AAG>AAC	p.K279N		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	279					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		AAAAAATAAAGAGGAGTCCGT	0.348		NaN											0	0	0	0.004656	0	28	69									
GSTM2	2946	broad.mit.edu	37	1	110213924	110213924	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:110213924G>A	uc001dyi.2	+	6	690	c.376G>A	c.(376-378)GAA>AAA	p.E126K	GSTM2_uc001dyj.2_Missense_Mutation_p.E126K|GSTM2_uc010ovt.1_Missense_Mutation_p.E126K|GSTM2_uc009wfk.2_RNA	NM_000848	NP_000839	P28161	GSTM2_HUMAN	glutathione S-transferase mu 2 isoform 1	126	GST C-terminal.				glutathione metabolic process|xenobiotic catabolic process	cytoplasm	glutathione transferase activity				0		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		all cancers(265;0.0122)|Colorectal(144;0.0129)|Epithelial(280;0.0146)|Lung(183;0.0422)|COAD - Colon adenocarcinoma(174;0.047)|LUSC - Lung squamous cell carcinoma(189;0.227)	Glutathione(DB00143)	ACTGAAACCAGAATACCTGCA	0.542		NaN											0	0	0	0.010818	0	33	33									
KCNC4	3749	broad.mit.edu	37	1	110766114	110766114	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:110766114G>A	uc001dzh.2	+	2	1264	c.1207G>A	c.(1207-1209)GAG>AAG	p.E403K	KCNC4_uc001dzf.2_Missense_Mutation_p.E403K|KCNC4_uc009wfr.2_Missense_Mutation_p.E403K|KCNC4_uc001dzg.2_Missense_Mutation_p.E403K|KCNC4_uc001dzi.2_RNA	NM_004978	NP_004969	Q03721	KCNC4_HUMAN	Shaw-related voltage-gated potassium channel	403					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTACTACGCTGAGCGCATTGG	0.592		NaN											0	0	0	0.00278	0	24	88									
DDX20	11218	broad.mit.edu	37	1	112299299	112299299	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:112299299G>A	uc001ebs.2	+	2	690	c.333G>A	c.(331-333)GGG>GGA	p.G111G	C1orf183_uc001ebp.1_5'Flank|uc001ebr.2_5'Flank|DDX20_uc010owf.1_5'UTR	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	111	Helicase ATP-binding.|ATP.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGCACCGGGAAAACCTGTG	0.428		NaN											0	0	0	0.010504	0	21	75									
PHTF1	10745	broad.mit.edu	37	1	114242367	114242367	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:114242367G>C	uc009wgp.1	-	16	2553	c.2101C>G	c.(2101-2103)CTA>GTA	p.L701V	PHTF1_uc001edm.2_Missense_Mutation_p.L458V	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	701	Basic motif.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTGTTTACTAGAGTAAGCTGT	0.284		NaN											0	0	0	0.009096	0	4	14									
AP4B1	10717	broad.mit.edu	37	1	114447326	114447326	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:114447326C>T	uc001eeb.2	-	1	157	c.14G>A	c.(13-15)GGC>GAC	p.G5D	AP4B1_uc001eec.2_Missense_Mutation_p.G5D|AP4B1_uc001eed.2_Missense_Mutation_p.G5D|AP4B1_uc010owp.1_5'UTR|AP4B1_uc010owq.1_Missense_Mutation_p.G5D|DCLRE1B_uc001eeg.2_5'Flank|DCLRE1B_uc001eeh.2_5'Flank|DCLRE1B_uc001eei.2_5'Flank	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	5					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTCCTCGGAGCCAAGGTACGG	0.562		NaN											0	0	0	0.01441	0	87	75									
CASQ2	845	broad.mit.edu	37	1	116245548	116245548	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:116245548G>A	uc001efx.3	-	10	1272	c.1008C>T	c.(1006-1008)GTC>GTT	p.V336V	CASQ2_uc010owu.1_Silent_p.V265V	NM_001232	NP_001223	O14958	CASQ2_HUMAN	cardiac calsequestrin 2 precursor	336					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TCACATCTGTGACATTCACCA	0.483		NaN											0	0	0	0.004482	0	9	15									
MAN1A2	10905	broad.mit.edu	37	1	117910898	117910898	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:117910898G>C	uc001ehd.1	+	1	814	c.93G>C	c.(91-93)TTG>TTC	p.L31F	MAN1A2_uc009whg.1_5'UTR	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	31	Cytoplasmic (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		GGGCTACCTTGAGACTTTCTG	0.493		NaN											0	0	0	0.00632	0	29	90									
SPAG17	200162	broad.mit.edu	37	1	118624072	118624072	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:118624072C>T	uc001ehk.2	-	14	2024	c.1956G>A	c.(1954-1956)ATG>ATA	p.M652I		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	652						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TATTCATTTTCATGACATATT	0.408		NaN											0	0	0	0.012213	0	32	107									
PDE4DIP	9659	broad.mit.edu	37	1	144952287	144952287	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:144952287C>T	uc001elw.3	-	4	723	c.432G>A	c.(430-432)CTG>CTA	p.L144L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Silent_p.L210L|PDE4DIP_uc001emc.1_Silent_p.L144L|PDE4DIP_uc001emd.1_Silent_p.L144L|PDE4DIP_uc001emg.1_Silent_p.L144L|PDE4DIP_uc001emh.2_Silent_p.L281L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	144					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGACTCCCTTCAGTTTCTCTG	0.542		NaN	T	PDGFRB	MPD								0	0	0	0.010504	0	8	101									
PDE4DIP	9659	broad.mit.edu	37	1	145075044	145075044	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:145075044C>T	uc001emk.2	-	2	467	c.250G>A	c.(250-252)GAT>AAT	p.D84N	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001emh.2_Intron			Q5VU43	MYOME_HUMAN	SubName: Full=Phosphodiesterase 4D interacting protein;	Error:Variant_position_missing_in_Q5VU43_after_alignment					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATCCAGCCATCAGGCAGGGCT	0.502		NaN	T	PDGFRB	MPD								0	0	0	0.006214	0	8	57									
NBPF10	100132406	broad.mit.edu	37	1	145293493	145293493	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:145293493G>A	uc001end.3	+	1	123	c.88G>A	c.(88-90)GAG>AAG	p.E30K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.E30K|NOTCH2NL_uc010oyh.1_RNA|NBPF10_uc001emq.1_Missense_Mutation_p.E30K	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	30											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CCAGCTGGCAGAGAAGAAACA	0.483		NaN											0	0	0	0.01441	0	40	685									
ANKRD35	148741	broad.mit.edu	37	1	145562892	145562892	+	Nonsense_Mutation	SNP	T	T	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:145562892T>G	uc001eob.1	+	10	2688	c.2580T>G	c.(2578-2580)TAT>TAG	p.Y860*	NBPF10_uc001emp.3_Intron|ANKRD35_uc010oyx.1_Nonsense_Mutation_p.Y703*	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	860	Potential.									ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGGAAAAGTATAATACGGCCT	0.677		NaN											0	0	0	0.013537	0	10	2									
RNF115	27246	broad.mit.edu	37	1	145688151	145688151	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:145688151G>A	uc001eoj.2	+	9	1050	c.846G>A	c.(844-846)CAG>CAA	p.Q282Q	NBPF10_uc001emp.3_Intron|RNF115_uc001eok.2_Silent_p.Q249Q|RNF115_uc009wiy.2_Silent_p.Q201Q	NM_014455	NP_055270	Q9Y4L5	RN115_HUMAN	Rabring 7	282					protein autoubiquitination	cytosol	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1						GGCAAAGCCAGAGCACTGAGG	0.458		NaN											0	0	0	0.01441	0	49	114									
GPR89B	51463	broad.mit.edu	37	1	147408770	147408770	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:147408770C>G	uc001epv.3	+	2	216	c.72C>G	c.(70-72)TTC>TTG	p.F24L	GPR89B_uc010ozs.1_Missense_Mutation_p.F24L|GPR89B_uc010ozt.1_5'UTR|GPR89B_uc010ozu.1_5'UTR|GPR89B_uc001epw.3_5'UTR|GPR89B_uc010ozv.1_5'UTR	NM_016334	NP_057418	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89B	24	Helical; (Potential).				intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(923;0.0276)					GGTGGCTTTTCTTCATGCGCC	0.294		NaN											0	0	0	0.005524	0	32	176									
HIST2H3D	653604	broad.mit.edu	37	1	149785205	149785205	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:149785205G>A	uc010pbl.1	-	1	32	c.32C>T	c.(31-33)TCG>TTG	p.S11L	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	11					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						GCCGCCGGTCGACTTGCGGGC	0.622		NaN											0	0	0	0.012319	0	13	28									
ANP32E	81611	broad.mit.edu	37	1	150193049	150193049	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:150193049G>A	uc001etw.2	-	7	1121	c.751C>T	c.(751-753)CGA>TGA	p.R251*	ANP32E_uc010pbt.1_RNA|ANP32E_uc010pbu.1_Nonsense_Mutation_p.R203*|ANP32E_uc010pbv.1_Nonsense_Mutation_p.R210*|ANP32E_uc001etv.3_Nonsense_Mutation_p.R250*	NM_030920	NP_112182	Q9BTT0	AN32E_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	251	Asp/Glu-rich (highly acidic).					cytoplasmic membrane-bounded vesicle|nucleus	phosphatase inhibitor activity				0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTCCCCTCGAAGACCTCCT	0.368		NaN											0	0	0	0.01441	0	316	154									
ADAMTSL4	54507	broad.mit.edu	37	1	150532646	150532646	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:150532646G>A	uc001eux.2	+	19	3435	c.3199G>A	c.(3199-3201)GAG>AAG	p.E1067K	ADAMTSL4_uc009wlw.2_Missense_Mutation_p.E1090K|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.E1028K|ADAMTSL4_uc009wlx.2_Missense_Mutation_p.E230K	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	1067					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			ACATGTCCTGGAGCGGTCTCC	0.627		NaN									OREG0013787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	83	24									
MCL1	4170	broad.mit.edu	37	1	150550774	150550774	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:150550774G>A	uc001euz.2	-	2	1012	c.882C>T	c.(880-882)ATC>ATT	p.I294I	MCL1_uc010pch.1_Silent_p.I184I|MCL1_uc001eva.2_Intron	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	294					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GAACGTCTGTGATACTTTCTG	0.453		NaN											0	0	0	0.00874	0	34	266									
PRUNE	58497	broad.mit.edu	37	1	150981133	150981133	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:150981133C>G	uc001ewh.1	+	1	161	c.25C>G	c.(25-27)CGA>GGA	p.R9G	PRUNE_uc001ewi.1_5'UTR|PRUNE_uc010pco.1_5'UTR|PRUNE_uc001ewj.1_5'UTR|FAM63A_uc001ewc.2_5'Flank|FAM63A_uc010pcm.1_5'Flank|FAM63A_uc001ewd.2_5'Flank|FAM63A_uc001ewe.2_5'Flank|FAM63A_uc001ewf.2_5'Flank|FAM63A_uc010pcn.1_5'Flank|FAM63A_uc001ewg.2_5'Flank	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	9						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCAGGGTTGTCGAGCTGCTCT	0.602		NaN											0	0	0	0.004878	0	35	203									
C1orf56	54964	broad.mit.edu	37	1	151021023	151021023	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151021023C>T	uc001ewn.2	+	1	765	c.700C>T	c.(700-702)CGA>TGA	p.R234*		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	234						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CGGGCGCCTTCGAGTTGGGGC	0.657		NaN									OREG0013793	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	206	86									
PI4KB	5298	broad.mit.edu	37	1	151288752	151288752	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151288752G>A	uc001ext.2	-	2	621	c.206C>T	c.(205-207)TCT>TTT	p.S69F	PI4KB_uc001exr.2_Missense_Mutation_p.S81F|PI4KB_uc001exs.2_Missense_Mutation_p.S69F|PI4KB_uc001exu.2_Missense_Mutation_p.S69F|PI4KB_uc010pcw.1_Intron|PI4KB_uc009wmq.1_Missense_Mutation_p.S81F	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	69					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GCCTCTGCTAGAGACTGCCAC	0.572		NaN											0	0	0	0.004007	0	15	137									
SELENBP1	8991	broad.mit.edu	37	1	151339220	151339220	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151339220G>A	uc001exx.2	-	6	689	c.642C>T	c.(640-642)TTC>TTT	p.F214F	SELENBP1_uc010pcy.1_Silent_p.F256F|SELENBP1_uc001exy.2_Silent_p.F111F|SELENBP1_uc001exz.2_Silent_p.F111F|SELENBP1_uc010pcz.1_Silent_p.F152F|SELENBP1_uc009wms.2_Intron|SELENBP1_uc009wmt.2_Silent_p.F111F|SELENBP1_uc001eya.2_Silent_p.F150F|SELENBP1_uc009wmu.2_Silent_p.F111F	NM_003944	NP_003935	Q13228	SBP1_HUMAN	selenium binding protein 1	214					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding				0	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGCGGGGTTGAAGCCATCTC	0.582		NaN											0	0	0	0.01441	0	51	225									
PSMB4	5692	broad.mit.edu	37	1	151372617	151372617	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151372617G>A	uc001eyc.1	+	2	324	c.301G>A	c.(301-303)GAC>AAC	p.D101N	PSMB4_uc010pda.1_Missense_Mutation_p.D101N|PSMB4_uc001eyb.1_Missense_Mutation_p.D101N	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	101					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TGCCTCTGGCGACTACGCTGA	0.537		NaN											0	0	0	0.01441	0	56	402									
TUFT1	7286	broad.mit.edu	37	1	151542174	151542174	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151542174G>C	uc001eyl.2	+	7	584	c.522G>C	c.(520-522)AAG>AAC	p.K174N	TUFT1_uc001eym.2_Missense_Mutation_p.K149N|TUFT1_uc010pdf.1_Missense_Mutation_p.K193N|TUFT1_uc010pdg.1_Missense_Mutation_p.K122N	NM_020127	NP_064512	Q9NNX1	TUFT1_HUMAN	tuftelin 1 isoform 1	174	Potential.				bone mineralization|odontogenesis	cytoplasm|extracellular region	structural constituent of tooth enamel				0	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCTTGAGGAAGACGGTGCAGG	0.512		NaN											0	0	0	0.01441	0	62	405									
RORC	6097	broad.mit.edu	37	1	151785508	151785508	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:151785508G>T	uc001ezh.2	-	9	1308	c.1200C>A	c.(1198-1200)ATC>ATA	p.I400I	RORC_uc001ezg.2_Silent_p.I379I|RORC_uc010pdo.1_Silent_p.I454I|RORC_uc010pdp.1_Silent_p.I388I	NM_005060	NP_005051	P51449	RORG_HUMAN	RAR-related orphan receptor C isoform a	400	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AGAAGTCAAAGATGGAGCTGA	0.537		NaN											1	0	1.49723e-40	0.01441	1.59186e-40	72	26									
TCHH	7062	broad.mit.edu	37	1	152083964	152083964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:152083964G>A	uc001ezp.2	-	2	1729	c.1729C>T	c.(1729-1731)CAG>TAG	p.Q577*	TCHH_uc009wne.1_Nonsense_Mutation_p.Q577*	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	577	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCAGCAGCTGATCGCGCCTC	0.672		NaN											0	0	0	0.003271	0	28	56									
FLG	2312	broad.mit.edu	37	1	152276091	152276091	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:152276091G>A	uc001ezu.1	-	3	11307	c.11271C>T	c.(11269-11271)ACC>ACT	p.T3757T		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3757	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCACGAATGGTGTCCTGAC	0.607		NaN							Ichthyosis				0	0	0	0.01441	0	559	215									
S100A6	6277	broad.mit.edu	37	1	153507246	153507246	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:153507246C>T	uc001fbw.1	-	3	513	c.199G>A	c.(199-201)GAG>AAG	p.E67K		NM_014624	NP_055439	P06703	S10A6_HUMAN	S100 calcium-binding protein A6	67	EF-hand 2.|2.				axonogenesis|positive regulation of fibroblast proliferation|signal transduction	cytosol|extrinsic to internal side of plasma membrane|nuclear envelope|perinuclear region of cytoplasm|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|S100 beta binding|tropomyosin binding			ovary(1)	1	all_lung(78;1.66e-32)|Lung NSC(65;5.71e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AAGTTCACCTCCTGGTCCTTG	0.478		NaN											0	0	0	0.01441	0	112	95									
ZBTB7B	51043	broad.mit.edu	37	1	154988999	154988999	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:154988999C>T	uc001fgk.3	+	4	1616	c.1458C>T	c.(1456-1458)CTC>CTT	p.L486L	ZBTB7B_uc009wpa.2_Silent_p.L486L|ZBTB7B_uc001fgj.3_Silent_p.L520L|ZBTB7B_uc010peq.1_Silent_p.L520L|ZBTB7B_uc001fgl.3_Silent_p.L486L	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	486					cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCCTCGACCTCTCCAATGGCC	0.682		NaN											0	0	0	0.010729	0	8	42									
MUC1	4582	broad.mit.edu	37	1	155161824	155161824	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:155161824G>A	uc010pft.1	-	2	375	c.309C>T	c.(307-309)GTC>GTT	p.V103V	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_5'Flank|MUC1_uc001fhz.2_5'Flank|MUC1_uc010pfb.1_Intron|MUC1_uc010pfc.1_Intron|MUC1_uc009wph.2_Intron|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_Intron|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Intron|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Intron|MUC1_uc010pfi.1_Intron|MUC1_uc010pfj.1_Intron|MUC1_uc010pfk.1_Intron|MUC1_uc010pfl.1_Intron|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Intron|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Intron|MUC1_uc009wpo.2_Intron|MUC1_uc009wps.2_Intron|MUC1_uc009wpt.2_Intron|MUC1_uc001fic.2_Intron|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Intron|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Intron|MUC1_uc001fid.2_Intron|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Intron|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Intron|MUC1_uc001fiq.2_Intron|MUC1_uc009wpz.2_Intron|MUC1_uc010pfn.1_Intron|MUC1_uc009wqa.2_Intron|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Intron|MUC1_uc009wqc.2_Intron|MUC1_uc009wqd.2_Intron|MUC1_uc009wqb.2_Intron|MUC1_uc010pfq.1_Intron|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Intron|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Intron|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_Intron|MUC1_uc001fik.2_Intron|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Intron|MUC1_uc001fis.1_Intron|uc009wqh.2_5'Flank|MUC1_uc001fiv.1_Silent_p.V112V|MUC1_uc001fiw.1_Silent_p.V103V			P15941	MUC1_HUMAN	SubName: Full=MUC1 isoform M13;	103	Extracellular (Potential).|3.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTGGCCTGGTGACTGGGACCG	0.697		NaN	T	IGH@	B-NHL								0	0	0	0.004482	0	9	50									
GON4L	54856	broad.mit.edu	37	1	155823271	155823271	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:155823271G>A	uc001flz.2	-	2	398	c.301C>T	c.(301-303)CAG>TAG	p.Q101*	GON4L_uc001fly.1_Nonsense_Mutation_p.Q101*|GON4L_uc009wrh.1_Nonsense_Mutation_p.Q101*|GON4L_uc001fma.1_Nonsense_Mutation_p.Q101*|GON4L_uc001fmc.2_Nonsense_Mutation_p.Q101*|GON4L_uc001fmd.3_Nonsense_Mutation_p.Q101*|GON4L_uc009wri.2_5'UTR	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	101					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTGATTCCCTGAGAGATGGCC	0.443		NaN											0	0	0	0.01441	0	49	362									
MEX3A	92312	broad.mit.edu	37	1	156051412	156051412	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156051412C>T	uc001fnd.3	-	1	378	c.378G>A	c.(376-378)CTG>CTA	p.L126L	LMNA_uc001fnf.1_5'Flank	NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	126						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					TGCTGCCCTTCAGGCGCAGCT	0.522		NaN											0	0	0	0.008871	0	19	0									
TMEM79	84283	broad.mit.edu	37	1	156256052	156256052	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156256052G>A	uc010phi.1	+	3	955	c.759G>A	c.(757-759)GGG>GGA	p.G253G	TMEM79_uc001fod.2_Silent_p.G94G|TMEM79_uc009wrw.2_Silent_p.G253G	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	253	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					TCCACCCAGGGATCCTGGTGT	0.612		NaN											0	0	0	0.003954	0	26	105									
C1orf85	112770	broad.mit.edu	37	1	156263941	156263941	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156263941C>T	uc001foh.2	-	4	679	c.666G>A	c.(664-666)CTG>CTA	p.L222L	C1orf85_uc001fof.3_5'Flank|C1orf85_uc001fog.1_Intron|C1orf85_uc001foi.2_Silent_p.L222L|C1orf85_uc009wrx.2_Silent_p.L155L|C1orf85_uc001foj.2_Silent_p.L136L	NM_144580	NP_653181	Q8WWB7	NCUG1_HUMAN	kidney predominant protein NCU-G1 precursor	222	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2	Hepatocellular(266;0.158)					AGGCTCCAATCAGGGCCACCT	0.627		NaN											0	0	0	0.01441	0	101	41									
CCT3	7203	broad.mit.edu	37	1	156280783	156280783	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156280783C>T	uc001fol.1	-	12	1579	c.1359G>A	c.(1357-1359)CAG>CAA	p.Q453Q	CCT3_uc001fom.1_Silent_p.Q452Q|CCT3_uc001fon.1_Silent_p.Q415Q|CCT3_uc010phj.1_Silent_p.Q407Q|CCT3_uc010phk.1_Silent_p.Q407Q|CCT3_uc010phl.1_Silent_p.Q407Q	NM_005998	NP_005989	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 isoform a	453					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CCCCACAGTTCTGGATCAGGG	0.537		NaN											0	0	0	0.010729	0	11	116									
RHBG	57127	broad.mit.edu	37	1	156354598	156354598	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:156354598G>A	uc010pho.1	+	11	1376	c.1338G>A	c.(1336-1338)CAG>CAA	p.Q446Q	RHBG_uc001fos.2_3'UTR|RHBG_uc009wrz.2_3'UTR|RHBG_uc001for.2_3'UTR	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	Error:Variant_position_missing_in_Q9H310_after_alignment					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					ATAAAGCCCAGAGACCTCTGA	0.592		NaN									OREG0013871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	34	8									
FCRL4	83417	broad.mit.edu	37	1	157550118	157550118	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:157550118C>T	uc001fqw.2	-	8	1406	c.1270G>A	c.(1270-1272)GAA>AAA	p.E424K	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	424	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CACCTGGTTTCGTCTCCCAAG	0.413		NaN											0	0	0	0.01441	0	202	80									
CCDC19	25790	broad.mit.edu	37	1	159842861	159842861	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:159842861C>T	uc001fui.2	-	11	1468	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.E399K|CCDC19_uc001ful.2_Missense_Mutation_p.E399K	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	484	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TGCTGGTTCTCGCGCACCTGG	0.602		NaN											0	0	0	0.008361	0	28	94									
IGSF8	93185	broad.mit.edu	37	1	160063790	160063790	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160063790G>T	uc001fva.2	-	3	659	c.614C>A	c.(613-615)TCT>TAT	p.S205Y	IGSF8_uc001fuz.2_Missense_Mutation_p.S205Y|IGSF8_uc009wtf.2_Missense_Mutation_p.S205Y	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	205	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CTCGGGCACAGATCGCCCAAA	0.627		NaN											1	0	4.45467e-35	0.011902	4.72927e-35	42	63									
CASQ1	844	broad.mit.edu	37	1	160162631	160162631	+	Missense_Mutation	SNP	G	G	A	rs143532190		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160162631G>A	uc010pja.1	+	2	576	c.319G>A	c.(319-321)GGG>AGG	p.G107R		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	107						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTTGGCTTCGGGCTGGTAGA	0.512		NaN									OREG0013927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004289	0	36	281									
CASQ1	844	broad.mit.edu	37	1	160163575	160163575	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160163575G>C	uc010pja.1	+	3	660	c.403G>C	c.(403-405)GAT>CAT	p.D135H		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	135						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATTCAAGGGAGATGAAGTCAT	0.532		NaN											0	0	0	0.010504	0	17	82									
COPA	1314	broad.mit.edu	37	1	160261692	160261692	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160261692C>T	uc009wti.2	-	30	3569	c.3175G>A	c.(3175-3177)GAG>AAG	p.E1059K	COPA_uc001fvv.3_Missense_Mutation_p.E1068K	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	1059					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACAATGTACTCACGGCAAATG	0.522		NaN									OREG0013929	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	367	115									
CD48	962	broad.mit.edu	37	1	160681499	160681499	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:160681499G>A	uc001fwn.2	-	1	87	c.55C>T	c.(55-57)CTG>TTG	p.L19L	CD48_uc001fwo.1_Silent_p.L19L|CD48_uc001fwp.2_Silent_p.L19L	NM_001778	NP_001769	P09326	CD48_HUMAN	CD48 molecule precursor	19					blood coagulation|defense response|leukocyte migration	integral to plasma membrane|membrane raft	protein binding				0	all_cancers(52;2.18e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			AGGAGTGACAGAGGCAGCAGT	0.532		NaN											0	0	0	0.01441	0	52	14									
MPZ	4359	broad.mit.edu	37	1	161277071	161277071	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161277071C>T	uc001gaf.3	-	2	278	c.241G>A	c.(241-243)GAA>AAA	p.E81K	MPZ_uc010pko.1_RNA	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero	71	Ig-like V-type.|Extracellular (Potential).				synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			CTGCCCCCTTCGGGCTGGTAG	0.552		NaN											0	0	0	0.001168	0	4	67									
FCGR2B	2213	broad.mit.edu	37	1	161641245	161641245	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161641245C>G	uc001gaz.1	+	3	289	c.197C>G	c.(196-198)TCT>TGT	p.S66C	FCGR2B_uc009wum.1_Missense_Mutation_p.S66C|FCGR2B_uc001gay.1_Missense_Mutation_p.S65C|FCGR2B_uc001gba.1_Missense_Mutation_p.S65C|FCGR2B_uc001gbb.1_Missense_Mutation_p.S66C|FCGR2B_uc009wun.1_Missense_Mutation_p.S59C	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	66	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CAGGAGGACTCTGTGACTCTG	0.587		NaN	T	NaN	ALL								0	0	0	0.006122	0	18	99									
FCGR2B	2213	broad.mit.edu	37	1	161641318	161641318	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161641318C>G	uc001gaz.1	+	3	362	c.270C>G	c.(268-270)CTC>CTG	p.L90L	FCGR2B_uc009wum.1_Silent_p.L90L|FCGR2B_uc001gay.1_Silent_p.L89L|FCGR2B_uc001gba.1_Silent_p.L89L|FCGR2B_uc001gbb.1_Silent_p.L90L|FCGR2B_uc009wun.1_Silent_p.L83L	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	90	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATGGGAATCTCATTCCCACCC	0.587		NaN	T	NaN	ALL								0	0	0	0.00499	0	15	87									
FCGR2B	2213	broad.mit.edu	37	1	161641408	161641408	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161641408C>T	uc001gaz.1	+	3	452	c.360C>T	c.(358-360)CTC>CTT	p.L120L	FCGR2B_uc009wum.1_Silent_p.L120L|FCGR2B_uc001gay.1_Silent_p.L119L|FCGR2B_uc001gba.1_Silent_p.L119L|FCGR2B_uc001gbb.1_Silent_p.L120L|FCGR2B_uc009wun.1_Silent_p.L113L	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	120	Ig-like C2-type 1.|Extracellular (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGACCAGCCTCAGCGACCCTG	0.592		NaN	T	NaN	ALL								0	0	0	0.013537	0	11	54									
FCRLB	127943	broad.mit.edu	37	1	161695648	161695648	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161695648C>T	uc001gbh.2	+	6	579	c.345C>T	c.(343-345)TTC>TTT	p.F115F	FCRLB_uc009wus.2_Silent_p.F115F|FCRLB_uc001gbj.2_Silent_p.F115F|FCRLB_uc001gbk.2_Silent_p.F115F|FCRLB_uc001gbl.2_Silent_p.F108F|FCRLB_uc001gbm.2_Silent_p.F108F|FCRLB_uc001gbi.2_Silent_p.F115F|FCRLB_uc001gbn.3_5'Flank	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	115	Ig-like C2-type 2.					endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CGCCAGTGTTCGAGGGTGAGC	0.592		NaN											0	0	0	0.001984	0	4	52									
FCRLB	127943	broad.mit.edu	37	1	161696695	161696695	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:161696695C>T	uc001gbh.2	+	7	1011	c.777C>T	c.(775-777)GTC>GTT	p.V259V	FCRLB_uc009wus.2_Silent_p.V259V|FCRLB_uc001gbj.2_Missense_Mutation_p.S211L|FCRLB_uc001gbk.2_Nonsense_Mutation_p.R225*|FCRLB_uc001gbl.2_Missense_Mutation_p.S204L|FCRLB_uc001gbm.2_Nonsense_Mutation_p.R218*|FCRLB_uc001gbi.2_Silent_p.V259V|FCRLB_uc001gbn.3_Nonsense_Mutation_p.R262*	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	259						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			AGCCCGAGGTCGAGGAGCTCG	0.687		NaN											0	0	0	0.004007	0	11	3									
BLZF1	8548	broad.mit.edu	37	1	169351514	169351514	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:169351514G>T	uc001gfx.1	+	6	1449	c.1012G>T	c.(1012-1014)GAA>TAA	p.E338*	BLZF1_uc001gfy.2_Nonsense_Mutation_p.E338*|BLZF1_uc009wvp.1_Intron	NM_003666	NP_003657	Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	338					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			skin(1)	1	all_hematologic(923;0.208)					GAAAATGGCTGAAACGGTAAA	0.279		NaN											1	0	4.3838e-07	0.001855	4.5106e-07	14	50									
SELE	6401	broad.mit.edu	37	1	169696928	169696928	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:169696928C>G	uc001ggm.3	-	9	1577	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	474	Extracellular (Potential).|Sushi 5.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GATGTGCACTCAAGTTGAGTT	0.448		NaN											0	0	0	0.01441	0	82	65									
RC3H1	149041	broad.mit.edu	37	1	173916678	173916678	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:173916678G>A	uc001gju.3	-	14	2653	c.2566C>T	c.(2566-2568)CAG>TAG	p.Q856*	RC3H1_uc010pms.1_Nonsense_Mutation_p.Q856*|RC3H1_uc001gjv.2_Nonsense_Mutation_p.Q856*|RC3H1_uc010pmt.1_Nonsense_Mutation_p.Q856*	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	856					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GCTCTTCTCTGAAGATCTAAT	0.438		NaN											0	0	0	0.010771	0	42	34									
RFWD2	64326	broad.mit.edu	37	1	176012859	176012859	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:176012859G>A	uc001gku.1	-	13	1773	c.1517C>T	c.(1516-1518)TCA>TTA	p.S506L	RFWD2_uc001gkv.1_Missense_Mutation_p.S482L|RFWD2_uc001gkw.1_Missense_Mutation_p.S266L|RFWD2_uc009wwv.2_Missense_Mutation_p.S305L|RFWD2_uc001gkt.1_Missense_Mutation_p.S345L	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	506	WD 2.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						ATAGACCTTTGACCTCTGTCC	0.353		NaN											0	0	0	0.01441	0	75	246									
SOAT1	6646	broad.mit.edu	37	1	179320459	179320459	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:179320459C>G	uc001gml.2	+	15	1521	c.1458C>G	c.(1456-1458)TTC>TTG	p.F486L	SOAT1_uc010pni.1_Missense_Mutation_p.F421L|SOAT1_uc001gmm.2_Missense_Mutation_p.F428L|SOAT1_uc010pnj.1_Missense_Mutation_p.F222L|SOAT1_uc010pnk.1_Missense_Mutation_p.F421L	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	486	Helical; (Potential).				cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	TAGTGGCTTTCAACTTCATTG	0.269		NaN											0	0	0	0.01441	0	57	169									
C1orf125	126859	broad.mit.edu	37	1	179339182	179339182	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:179339182G>A	uc001gmo.2	+	4	470	c.343G>A	c.(343-345)GAC>AAC	p.D115N	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_5'UTR|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.D115N	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	115											0						ATACCTGATTGACCATCCCGT	0.413		NaN											0	0	0	0.008291	0	9	31									
TDRD5	163589	broad.mit.edu	37	1	179609578	179609578	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:179609578G>C	uc001gnf.1	+	11	2048	c.1798G>C	c.(1798-1800)GAG>CAG	p.E600Q	TDRD5_uc010pnp.1_Missense_Mutation_p.E600Q|TDRD5_uc001gnh.1_Missense_Mutation_p.E155Q	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	600					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GAGACCAGTAGAGGTATGTTT	0.264		NaN											0	0	0	0.012319	0	19	89									
CEP350	9857	broad.mit.edu	37	1	180080149	180080149	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:180080149G>A	uc001gnt.2	+	38	9590	c.9207G>A	c.(9205-9207)GAG>GAA	p.E3069E	CEP350_uc009wxl.2_Silent_p.E3068E|CEP350_uc001gnv.2_Silent_p.E1204E|CEP350_uc001gnw.1_Silent_p.E826E|CEP350_uc001gnx.1_Silent_p.E826E	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	3069						centrosome|nucleus|spindle				ovary(4)	4						AGCTCCATGAGGAGGAGGCAC	0.413		NaN											0	0	0	0.007413	0	17	59									
RGS16	6004	broad.mit.edu	37	1	182571103	182571103	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:182571103C>T	uc001gpl.3	-	4	539	c.385G>A	c.(385-387)GAG>AAG	p.E129K	RGS16_uc010pnv.1_Missense_Mutation_p.E129K	NM_002928	NP_002919	O15492	RGS16_HUMAN	regulator of G-protein signalling 16	129	RGS.				negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(1)	1						GCTCTAACCTCTTTAGGGGCC	0.567		NaN									OREG0014036	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.005524	0	39	43									
DHX9	1660	broad.mit.edu	37	1	182845653	182845653	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:182845653C>T	uc001gpr.2	+	18	2264	c.2101C>T	c.(2101-2103)CCA>TCA	p.P701S	DHX9_uc001gps.2_Missense_Mutation_p.P487S|DHX9_uc001gpt.2_5'Flank	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	701	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						AGTGTTTGATCCAGTACCAGT	0.403		NaN											0	0	0	0.00632	0	28	38									
C1orf26	54823	broad.mit.edu	37	1	185171807	185171807	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:185171807C>G	uc001grg.3	+	11	1659	c.1545C>G	c.(1543-1545)AAC>AAG	p.N515K	C1orf26_uc001grh.3_Missense_Mutation_p.N515K	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	515	PINc.										0						ACTTAAGAAACAAAGGCCTAA	0.368		NaN											0	0	0	0.005443	0	28	56									
IVNS1ABP	10625	broad.mit.edu	37	1	185276692	185276692	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:185276692C>T	uc001grl.2	-	6	1083	c.460G>A	c.(460-462)GAT>AAT	p.D154N	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	154	BACK.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						ATATAAGCATCAACCTTATTC	0.368		NaN											0	0	0	0.010818	0	34	39									
HMCN1	83872	broad.mit.edu	37	1	185703957	185703957	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:185703957C>G	uc001grq.1	+	1	275	c.46C>G	c.(46-48)CTT>GTT	p.L16V		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	16					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTTTGCTCTTCTTTATTCTTC	0.488		NaN											0	0	0	0.01441	0	106	108									
PLA2G4A	5321	broad.mit.edu	37	1	186946811	186946811	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:186946811G>T	uc001gsc.2	+	16	2056	c.1851G>T	c.(1849-1851)CTG>CTT	p.L617L	PLA2G4A_uc010pos.1_Silent_p.L557L	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	617	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	GGGAAGGGCTGAAGGAGTGCT	0.423		NaN											1	0	1.77063e-15	0.005443	1.86247e-15	27	81									
KCNT2	343450	broad.mit.edu	37	1	196342316	196342316	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:196342316C>T	uc001gtd.1	-	14	1417	c.1357G>A	c.(1357-1359)GCA>ACA	p.A453T	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.A453T|KCNT2_uc001gtf.1_Missense_Mutation_p.A453T|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.A453T|KCNT2_uc009wyv.1_Missense_Mutation_p.A428T	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	453	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GTAGATGTTGCTGGGCATATA	0.284		NaN											0	0	0	0.010818	0	31	103									
ZBTB41	360023	broad.mit.edu	37	1	197145778	197145778	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:197145778C>T	uc001gtx.1	-	7	1864	c.1795G>A	c.(1795-1797)GAT>AAT	p.D599N	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	599					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						CTTTTATCATCATGATGTACT	0.303		NaN											0	0	0	0.01441	0	59	71									
NEK7	140609	broad.mit.edu	37	1	198288556	198288556	+	Silent	SNP	T	T	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:198288556T>G	uc001gun.3	+	10	1140	c.813T>G	c.(811-813)GTT>GTG	p.V271V		NM_133494	NP_598001	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	271	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|lung(1)|ovary(1)	4						GACAGTTAGTTAATATGTGCA	0.383		NaN											0	0	0	0.008291	0	11	35									
ZNF281	23528	broad.mit.edu	37	1	200377338	200377338	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:200377338G>A	uc001gve.2	-	2	1603	c.1496C>T	c.(1495-1497)CCA>CTA	p.P499L	ZNF281_uc001gvf.1_Missense_Mutation_p.P499L|ZNF281_uc001gvg.1_Missense_Mutation_p.P463L	NM_012482	NP_036614	Q9Y2X9	ZN281_HUMAN	zinc finger protein 281	499					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)	2						TGAGCCACTTGGTTTTCCAGA	0.368		NaN											0	0	0	0.004878	0	37	124									
C1orf106	55765	broad.mit.edu	37	1	200878016	200878016	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:200878016G>A	uc001gvo.2	+	7	1018	c.988G>A	c.(988-990)GAC>AAC	p.D330N	C1orf106_uc010ppm.1_Missense_Mutation_p.D245N	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	330	Pro-rich.									skin(2)|ovary(1)	3						AACCAGCCTGGACCACCCCTA	0.642		NaN											0	0	0	0.010729	0	9	44									
C1orf106	55765	broad.mit.edu	37	1	200880945	200880945	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:200880945G>A	uc001gvo.2	+	9	1609	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K	C1orf106_uc010ppm.1_Missense_Mutation_p.E442K	NM_018265	NP_060735	Q3KP66	CA106_HUMAN	hypothetical protein LOC55765 isoform 1	527										skin(2)|ovary(1)	3						GGTGGTGGCTGAGAGCCCCCT	0.731		NaN											0	0	0	0.001984	0	4	12									
PPP1R12B	4660	broad.mit.edu	37	1	202318026	202318026	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:202318026G>A	uc001gya.1	+	1	191	c.47G>A	c.(46-48)CGA>CAA	p.R16Q	PPP1R12B_uc001gxy.2_Missense_Mutation_p.R16Q|PPP1R12B_uc009xad.1_5'UTR|PPP1R12B_uc009xae.1_Missense_Mutation_p.R16Q|PPP1R12B_uc001gxz.1_Missense_Mutation_p.R16Q	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	16					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GAGTCGGCGCGAATGCGGCGG	0.682		NaN											0	0	0	0.004672	0	3	6									
BTG2	7832	broad.mit.edu	37	1	203276346	203276346	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:203276346G>A	uc001gzq.2	+	2	328	c.257G>A	c.(256-258)GGA>GAA	p.G86E	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	86					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			AGCCAGATCGGACTCAGCCAG	0.632		NaN											0	0	0	0.013537	0	11	38									
REN	5972	broad.mit.edu	37	1	204125005	204125005	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:204125005G>A	uc001haq.2	-	9	1046	c.1002C>T	c.(1000-1002)ATC>ATT	p.I334I		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	334					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	GGTGGAAAGAGATGTCGGGGA	0.567		NaN											0	0	0	0.00308	0	8	9									
CDK18	5129	broad.mit.edu	37	1	205498223	205498223	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:205498223C>T	uc001hcr.2	+	11	1380	c.1161C>T	c.(1159-1161)CTC>CTT	p.L387L	CDK18_uc001hcp.2_Silent_p.L357L|CDK18_uc001hcq.2_Silent_p.L357L|CDK18_uc010prj.1_Silent_p.L268L|CDK18_uc001hcs.2_Silent_p.L268L|CDK18_uc009xbm.1_Silent_p.L282L|CDK18_uc001hct.2_5'Flank	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	355	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						TTCGCCTCCTCGGTCAGTCTC	0.706		NaN									OREG0014157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	1									
SLC41A1	254428	broad.mit.edu	37	1	205767810	205767810	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:205767810G>A	uc001hdh.1	-	6	1703	c.831C>T	c.(829-831)CTC>CTT	p.L277L	SLC41A1_uc001hdg.1_5'Flank|uc001hdi.1_5'Flank	NM_173854	NP_776253	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 member 1	277	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			skin(2)	2	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GTTCCAGGTAGAGTCCCCAGC	0.557		NaN											0	0	0	0.007413	0	19	87									
MAPKAPK2	9261	broad.mit.edu	37	1	206904547	206904547	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:206904547C>T	uc001hem.1	+	7	1118	c.832C>T	c.(832-834)CGC>TGC	p.R278C	MAPKAPK2_uc001hel.1_Missense_Mutation_p.R278C	NM_032960	NP_116584	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated	278	Protein kinase.				activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity				0	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			CATGAAGACTCGCATCCGAAT	0.537		NaN											0	0	0	0.010504	0	20	63									
C4BPA	722	broad.mit.edu	37	1	207317297	207317297	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:207317297G>A	uc001hfo.2	+	11	1773	c.1579G>A	c.(1579-1581)GGG>AGG	p.G527R		NM_000715	NP_000706	P04003	C4BPA_HUMAN	complement component 4 binding protein, alpha	527	Sushi 8.				complement activation, classical pathway|innate immune response	extracellular region	protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CACTTGCTCTGGGAACAGAAC	0.493		NaN											0	0	0	0.010818	0	32	51									
NEK2	4751	broad.mit.edu	37	1	211842601	211842601	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:211842601C>T	uc001hir.1	-	6	985	c.839G>A	c.(838-840)AGA>AAA	p.R280K	NEK2_uc001hiq.1_Missense_Mutation_p.R280K|NEK2_uc001his.3_Missense_Mutation_p.R280K|NEK2_uc001hit.1_RNA	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	280	Interaction with PCNT.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		AAGATTTCTTCTTTGCTCGTC	0.408		NaN											0	0	0	0.00874	0	41	132									
INTS7	25896	broad.mit.edu	37	1	212118233	212118233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:212118233C>T	uc001hiw.1	-	19	2599	c.2494G>A	c.(2494-2496)GAG>AAG	p.E832K	INTS7_uc009xdb.1_Missense_Mutation_p.E812K|INTS7_uc001hix.1_Missense_Mutation_p.E708K|INTS7_uc001hiy.1_Missense_Mutation_p.E818K|INTS7_uc010pta.1_Missense_Mutation_p.E783K	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	832					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		ACCACTCCCTCTACCTTTAGC	0.498		NaN											0	0	0	0.003954	0	26	80									
USH2A	7399	broad.mit.edu	37	1	216019244	216019244	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:216019244A>G	uc001hku.1	-	45	9364	c.8977T>C	c.(8977-8979)TAT>CAT	p.Y2993H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2993	Fibronectin type-III 16.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAGATCCAATACTCTGTGTTT	0.433		NaN								HNSCC(13;0.011)			0	0	0	0.003163	0	14	54									
EPRS	2058	broad.mit.edu	37	1	220146632	220146632	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:220146632C>G	uc001hly.1	-	29	4462	c.4192G>C	c.(4192-4194)GAG>CAG	p.E1398Q		NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	1398	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AGTTTAGTCTCTGCCTCATTT	0.433		NaN											0	0	0	0.00874	0	42	60									
HLX	3142	broad.mit.edu	37	1	221057702	221057702	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:221057702G>A	uc001hmv.3	+	4	1580	c.1123G>A	c.(1123-1125)GAG>AAG	p.E375K		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	375	Ser-rich.				cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		AGGCGAGGCTGAGAGCGAGAG	0.632		NaN											0	0	0	0.004007	0	11	13									
DUSP10	11221	broad.mit.edu	37	1	221875931	221875931	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:221875931C>T	uc001hmy.1	-	4	1454	c.1272G>A	c.(1270-1272)ATG>ATA	p.M424I	DUSP10_uc001hmx.1_Missense_Mutation_p.M82I|DUSP10_uc001hmz.1_Missense_Mutation_p.M82I	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	424	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GAGTGTGCTTCATCAAGTAAG	0.507		NaN											0	0	0	0.01441	0	92	59									
NVL	4931	broad.mit.edu	37	1	224492452	224492452	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:224492452C>T	uc001hok.2	-	8	854	c.811G>A	c.(811-813)GAT>AAT	p.D271N	NVL_uc001hol.2_Missense_Mutation_p.D165N|NVL_uc010pvd.1_Missense_Mutation_p.D180N|NVL_uc010pve.1_Missense_Mutation_p.D55N|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	271						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		AATGTCATATCATTGCCTCCC	0.343		NaN											0	0	0	0.01441	0	45	216									
OBSCN	84033	broad.mit.edu	37	1	228505341	228505341	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:228505341G>A	uc009xez.1	+	52	13782	c.13738G>A	c.(13738-13740)GAG>AAG	p.E4580K	OBSCN_uc001hsn.2_Missense_Mutation_p.E4580K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4580	Fibronectin type-III 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCCTGGACCCGAGTGTGTGGT	0.687		NaN											0	0	0	0.008291	0	10	17									
TRIM11	81559	broad.mit.edu	37	1	228582712	228582712	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:228582712C>T	uc001hss.2	-	6	1356	c.1101G>A	c.(1099-1101)GAG>GAA	p.E367E	TRIM11_uc010pvx.1_Silent_p.E366E	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	367	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			lung(3)|ovary(1)	4		Prostate(94;0.0724)				GCTCGCCCTTCTCCTTCCTGT	0.647		NaN											0	0	0	0.003954	0	22	19									
PGBD5	79605	broad.mit.edu	37	1	230486730	230486730	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:230486730A>G	uc010pwb.1	-	3	661	c.661T>C	c.(661-663)TGT>CGT	p.C221R	PGBD5_uc001htv.2_Missense_Mutation_p.C320R	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	221						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		GTGGAAGAACATTGTCTGACC	0.567		NaN											0	0	0	0.003954	0	24	58									
AGT	183	broad.mit.edu	37	1	230845940	230845940	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:230845940C>T	uc001hty.3	-	2	1165	c.657G>A	c.(655-657)CTG>CTA	p.L219L	AGT_uc009xfe.2_Silent_p.L219L|AGT_uc009xff.2_Silent_p.L191L	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	219					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	ACGGCTGCTTCAGGTGCAGGC	0.617		NaN											0	0	0	0.004007	0	16	23									
GNG4	2786	broad.mit.edu	37	1	235747067	235747067	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:235747067C>G	uc001hxe.3	-	3	526	c.72G>C	c.(70-72)AAG>AAC	p.K24N	GNG4_uc009xfz.2_Missense_Mutation_p.K24N|GNG4_uc001hxh.3_Missense_Mutation_p.K24N	NM_001098722	NP_001092192	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein),	24					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			AGGCTTCCATCTTTAGCTGCT	0.512		NaN											0	0	0	0.01441	0	79	69									
GNG4	2786	broad.mit.edu	37	1	235747078	235747078	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:235747078C>T	uc001hxe.3	-	3	515	c.61G>A	c.(61-63)GAG>AAG	p.E21K	GNG4_uc009xfz.2_Missense_Mutation_p.E21K|GNG4_uc001hxh.3_Missense_Mutation_p.E21K	NM_001098722	NP_001092192	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein),	21					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			TTTAGCTGCTCCACAGCTTTC	0.507		NaN											0	0	0	0.01441	0	89	76									
NID1	4811	broad.mit.edu	37	1	236228224	236228224	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:236228224G>A	uc001hxo.2	-	1	258	c.156C>T	c.(154-156)TTC>TTT	p.F52F	NID1_uc009xgd.2_Silent_p.F52F|uc001hxp.1_Missense_Mutation_p.R122Q	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	52					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CAGGAGAGACGAAGTCATCCC	0.697		NaN											0	0	0	0.010729	0	11	6									
HEATR1	55127	broad.mit.edu	37	1	236738083	236738083	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:236738083C>G	uc001hyd.1	-	23	3330	c.3205G>C	c.(3205-3207)GAA>CAA	p.E1069Q	HEATR1_uc009xgh.1_Intron	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1069					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			ACTGAAAATTCATTATACTTT	0.428		NaN											0	0	0	0.00874	0	42	39									
SDCCAG8	10806	broad.mit.edu	37	1	243480080	243480080	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:243480080C>T	uc001hzw.2	+	9	1109	c.953C>T	c.(952-954)GCA>GTA	p.A318V	SDCCAG8_uc010pyk.1_Missense_Mutation_p.A173V|SDCCAG8_uc010pyl.1_Missense_Mutation_p.A130V|SDCCAG8_uc001hzx.2_Missense_Mutation_p.A130V	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	318	Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TTGATGTCTGCACTAGTTTCC	0.413		NaN											0	0	0	0.00632	0	28	50									
ZNF238	10472	broad.mit.edu	37	1	244218572	244218572	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:244218572G>C	uc001iae.2	+	1	1991	c.1469G>C	c.(1468-1470)TGT>TCT	p.C490S	ZNF238_uc001iad.3_Missense_Mutation_p.C499S|ZNF238_uc001iaf.1_3'UTR	NM_006352	NP_006343	Q99592	ZN238_HUMAN	zinc finger protein 238 isoform 2	490					negative regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|pancreas(2)	5	all_cancers(71;6.42e-05)|all_epithelial(71;7e-05)|Breast(184;0.0333)|Ovarian(71;0.0619)|all_lung(81;0.089)|all_neural(11;0.101)|Lung NSC(105;0.123)		all cancers(7;1.35e-08)|GBM - Glioblastoma multiforme(7;1e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00223)			AAGTTCCACTGTGAGTTGGTG	0.547		NaN											0	0	0	0.014323	0	21	71									
KIF26B	55083	broad.mit.edu	37	1	245851077	245851077	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:245851077C>G	uc001ibf.1	+	12	5232	c.4792C>G	c.(4792-4794)CTG>GTG	p.L1598V	KIF26B_uc001ibg.1_Missense_Mutation_p.L1216V|KIF26B_uc001ibh.1_Missense_Mutation_p.L840V	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1598					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			GACTCCCCCTCTGCCCCCTGT	0.687		NaN											0	0	0	0.004672	0	3	1									
TFB2M	64216	broad.mit.edu	37	1	246729307	246729307	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:246729307G>A	uc001ibn.2	-	1	259	c.134C>T	c.(133-135)TCT>TTT	p.S45F	CNST_uc001ibo.3_5'Flank|CNST_uc001ibp.2_5'Flank|TFB2M_uc010pys.1_RNA	NM_022366	NP_071761	Q9H5Q4	TFB2M_HUMAN	transcription factor B2, mitochondrial	45					positive regulation of transcription, DNA-dependent|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity			ovary(1)	1	all_cancers(71;4.25e-05)|all_epithelial(71;4.92e-06)|Ovarian(71;0.0254)|all_lung(81;0.0272)|Breast(184;0.0318)|Lung NSC(105;0.0376)		OV - Ovarian serous cystadenocarcinoma(106;0.00358)			AGAGGAGTCAGAGAGCCCACA	0.592		NaN											0	0	0	0.003163	0	14	60									
TRIM58	25893	broad.mit.edu	37	1	248039263	248039263	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:248039263C>T	uc001ido.2	+	6	981	c.933C>T	c.(931-933)CGC>CGT	p.R311R	OR2W3_uc001idp.1_5'UTR	NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	311	B30.2/SPRY.					intracellular	zinc ion binding	p.R311C(1)		skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCGACCTGCGCAGTGTGCAGG	0.572		NaN											0	0	0	0.00499	0	16	30									
OR2T3	343173	broad.mit.edu	37	1	248637237	248637237	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:248637237G>A	uc001iel.1	+	1	586	c.586G>A	c.(586-588)GAC>AAC	p.D196N		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTCCTGCTCTGACGTCTCCCT	0.522		NaN											0	0	0	0.01441	0	76	93									
AKR1E2	83592	broad.mit.edu	37	10	4875593	4875593	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:4875593A>G	uc001ihi.2	+	3	374	c.259A>G	c.(259-261)AGT>GGT	p.S87G	AKR1E2_uc001ihl.1_RNA|AKR1E2_uc010qam.1_Intron|AKR1E2_uc001ihh.1_Missense_Mutation_p.S87G|AKR1E2_uc009xhw.2_Missense_Mutation_p.S87G|AKR1E2_uc001ihj.2_RNA|AKR1E2_uc001ihk.2_Missense_Mutation_p.S87G	NM_001040177	NP_001035267	Q96JD6	AKCL2_HUMAN	aldo-keto reductase family 1, member E2	87						cytoplasm	1,5-anhydro-D-fructose reductase activity				0						ATGCAGAAAGAGTCTCAAGGC	0.527		NaN											0	0	0	0.006214	0	9	425									
AKR1C1	1645	broad.mit.edu	37	10	5009208	5009208	+	Silent	SNP	C	C	T	rs138894545	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:5009208C>T	uc001iho.2	+	8	1183	c.342C>T	c.(340-342)TAC>TAT	p.Y114Y	AKR1E2_uc001ihl.1_Intron|AKR1C2_uc010qan.1_Intron|AKR1C3_uc001ihr.2_Intron|AKR1C1_uc009xhx.2_Silent_p.Y114Y|AKR1C1_uc001ihq.2_Silent_p.Y114Y	NM_001353	NP_001344	Q04828	AK1C1_HUMAN	aldo-keto reductase family 1, member C1	114					bile acid and bile salt transport|bile acid metabolic process|cholesterol homeostasis|intestinal cholesterol absorption|protein homooligomerization|response to organophosphorus|xenobiotic metabolic process	cytosol	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|aldo-keto reductase (NADP) activity|androsterone dehydrogenase (B-specific) activity|bile acid binding|indanol dehydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			ovary(2)	2					NADH(DB00157)	TTGACCTCTACCTTATTCATT	0.383		NaN											0	0	0	0.012319	0	5	191									
FRMD4A	55691	broad.mit.edu	37	10	13708121	13708121	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:13708121G>A	uc001ims.2	-	18	1931	c.1579C>T	c.(1579-1581)CAG>TAG	p.Q527*	FRMD4A_uc009xjf.1_Nonsense_Mutation_p.Q527*|FRMD4A_uc001imt.1_Nonsense_Mutation_p.Q560*	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	527						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GAAGCCCTCTGGGTGGGTTTC	0.567		NaN											0	0	0	0.01441	0	116	109									
PTPLA	9200	broad.mit.edu	37	10	17641359	17641359	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:17641359C>T	uc001ipg.2	-	5	570	c.535G>A	c.(535-537)GAG>AAG	p.E179K		NM_014241	NP_055056	B0YJ81	HACD1_HUMAN	protein tyrosine phosphatase-like, member A	179	Helical; (Potential).				fatty acid biosynthetic process|multicellular organismal development|signal transduction	endoplasmic reticulum membrane|integral to membrane	lyase activity|protein tyrosine phosphatase activity			central_nervous_system(1)|skin(1)	2						CGAGTGATCTCTGTCACAGTC	0.443		NaN											0	0	0	0.007413	0	17	31									
PLXDC2	84898	broad.mit.edu	37	10	20436813	20436813	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:20436813C>T	uc001iqg.1	+	6	1402	c.765C>T	c.(763-765)ATC>ATT	p.I255I	PLXDC2_uc001iqh.1_Silent_p.I206I|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	255	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						ATGGACGAATCATCTTTGGAT	0.453		NaN											0	0	0	0.014323	0	21	48									
C10orf114	399726	broad.mit.edu	37	10	21785724	21785724	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:21785724G>A	uc001iqn.3	-	1	490	c.20C>T	c.(19-21)TCA>TTA	p.S7L	MIR1915_hsa-mir-1915|MI0008336_5'Flank	NM_001010911	NP_001010911	Q5T4H9	CJ114_HUMAN	hypothetical protein LOC399726	7											0						GCGCCACCCTGAGGGCTCCCG	0.647		NaN											0	0	0	0.000602	0	3	9									
C10orf140	387640	broad.mit.edu	37	10	21804624	21804624	+	Missense_Mutation	SNP	C	C	T	rs35145063		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:21804624C>T	uc009xkd.2	-	4	4381	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	629						nucleus	nucleotide binding			ovary(1)	1						TCATTGCACTCGCACTTTAGC	0.393		NaN											0	0	0	0.01441	0	162	174									
KIAA1217	56243	broad.mit.edu	37	10	24832553	24832553	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:24832553G>A	uc001iru.3	+	19	4757	c.4354G>A	c.(4354-4356)GAC>AAC	p.D1452N	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Missense_Mutation_p.D1135N|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Missense_Mutation_p.D288N	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1452					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						TGAGCCCATGGACATCCGGTC	0.393		NaN											0	0	0	0.013114	0	44	46									
ACBD5	91452	broad.mit.edu	37	10	27524079	27524079	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:27524079C>T	uc010qdp.1	-	3	435	c.244G>A	c.(244-246)GAA>AAA	p.E82K	ACBD5_uc010qdm.1_Missense_Mutation_p.E80K|ACBD5_uc010qdn.1_Intron|ACBD5_uc010qdo.1_Intron|ACBD5_uc001ito.2_Missense_Mutation_p.E47K|ACBD5_uc001itp.2_Intron|ACBD5_uc001itq.2_Intron|ACBD5_uc001itr.1_Intron	NM_145698	NP_663736	Q5T8D3	ACBD5_HUMAN	acyl-Coenzyme A binding domain containing 5	80	ACB.				transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding				0						CAGGGTCCTTCAGTTGCCTGC	0.343		NaN											0	0	0	0.012319	0	23	58									
SVIL	6840	broad.mit.edu	37	10	29811369	29811369	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:29811369G>A	uc001iut.1	-	16	4112	c.3359C>T	c.(3358-3360)TCA>TTA	p.S1120L	SVIL_uc010qdw.1_Missense_Mutation_p.S18L|SVIL_uc001iuu.1_Missense_Mutation_p.S694L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1120					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TTTGCTGGGTGAGTCAAGAAG	0.468		NaN											0	0	0	0.013726	0	32	30									
GJD4	219770	broad.mit.edu	37	10	35894525	35894525	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:35894525C>T	uc001iyy.1	+	1	188	c.30C>T	c.(28-30)CTC>CTT	p.L10L		NM_153368	NP_699199	Q96KN9	CXD4_HUMAN	connexin40.1	10	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane				large_intestine(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TAGGGTTTCTCATCATCACAT	0.517		NaN											0	0	0	0.001855	0	12	34									
ANKRD30A	91074	broad.mit.edu	37	10	37508401	37508401	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:37508401C>T	uc001iza.1	+	34	3692	c.3593C>T	c.(3592-3594)TCT>TTT	p.S1198F		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1254						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CAACCACTTTCTGAAGCTCAA	0.373		NaN											0	0	0	0.01441	0	55	43									
BMS1	9790	broad.mit.edu	37	10	43292488	43292488	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:43292488C>T	uc001jaj.2	+	10	2154	c.1796C>T	c.(1795-1797)TCA>TTA	p.S599L		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	599					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GAAAGCTCCTCACTCAGTGCA	0.458		NaN											0	0	0	0.01441	0	86	80									
RET	5979	broad.mit.edu	37	10	43612094	43612094	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:43612094C>T	uc001jal.2	+	12	2389	c.2199C>T	c.(2197-2199)GGC>GGT	p.G733G	RET_uc001jak.1_Silent_p.G733G|RET_uc010qez.1_Silent_p.G479G	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	733	Protein kinase.|ATP (By similarity).|Cytoplasmic (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	TAGGAGAAGGCGAATTTGGAA	0.527		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				0	0	0	0.01441	0	41	256									
CSGALNACT2	55454	broad.mit.edu	37	10	43651198	43651198	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:43651198G>A	uc001jan.2	+	2	936	c.601G>A	c.(601-603)GAA>AAA	p.E201K	CSGALNACT2_uc001jam.1_Missense_Mutation_p.E201K	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	201	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						TGATGAACAAGAAGATGAGGA	0.363		NaN											0	0	0	0.005524	0	37	90									
TMEM72	643236	broad.mit.edu	37	10	45430175	45430175	+	Missense_Mutation	SNP	G	G	A	rs140679942	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:45430175G>A	uc001jbn.2	+	5	618	c.421G>A	c.(421-423)GAG>AAG	p.E141K	uc001jbk.1_Intron|uc001jbl.2_Intron|TMEM72_uc009xmm.1_Missense_Mutation_p.E23K	NM_001123376	NP_001116848	A0PK05	TMM72_HUMAN	transmembrane protein 72	141						integral to membrane					0						AGCTGCCCCCGAGGTGCTGGC	0.602		NaN											0	0	0	0.005524	0	33	194									
SYT15	83849	broad.mit.edu	37	10	46963894	46963894	+	Missense_Mutation	SNP	C	C	T	rs2484844		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:46963894C>T	uc001jea.2	-	7	1222	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	SYT15_uc001jdz.2_Missense_Mutation_p.E357K|SYT15_uc001jeb.2_Missense_Mutation_p.E235K|SYT15_uc010qfp.1_RNA	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	357	Cytoplasmic (Potential).|C2 2.					integral to membrane|plasma membrane					0						GTATCCAGCTCGGTGGCATCG	0.567		NaN											0	0	0	0.000602	0	5	96									
GDF2	2658	broad.mit.edu	37	10	48416478	48416478	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:48416478C>G	uc001jfa.1	-	1	379	c.216G>C	c.(214-216)CTG>CTC	p.L72L		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	72					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						GGACCCCACTCAGGTTAAGGC	0.577		NaN											0	0	0	0.008871	0	18	65									
GDF2	2658	broad.mit.edu	37	10	48416501	48416501	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:48416501C>G	uc001jfa.1	-	1	356	c.193G>C	c.(193-195)GAT>CAT	p.D65H		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	65					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						CGCAGGAAATCCACCTTCACG	0.587		NaN											0	0	0	0.006122	0	18	67									
DKK1	22943	broad.mit.edu	37	10	54076536	54076536	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:54076536C>T	uc001jjr.2	+	4	924	c.770C>T	c.(769-771)TCT>TTT	p.S257F	uc001jjq.1_5'Flank|uc009xox.1_5'Flank	NM_012242	NP_036374	O94907	DKK1_HUMAN	dickkopf homolog 1 precursor	257	DKK-type Cys-2.				negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						GCCAGTAATTCTTCTAGGCTT	0.403		NaN											0	0	0	0.01441	0	59	39									
ARID5B	84159	broad.mit.edu	37	10	63700148	63700148	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:63700148C>T	uc001jlt.1	+	3	509	c.483C>T	c.(481-483)CTC>CTT	p.L161L	ARID5B_uc010qil.1_Silent_p.L161L	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	161					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			ovary(2)|upper_aerodigestive_tract(1)|kidney(1)	4	Prostate(12;0.016)|all_hematologic(501;0.215)					AAGACGTTCTCAAGGAGAAGG	0.418		NaN											0	0	0	0.007413	0	18	15									
JMJD1C	221037	broad.mit.edu	37	10	64967741	64967741	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:64967741G>T	uc001jmn.2	-	10	3988	c.3688C>A	c.(3688-3690)CCA>ACA	p.P1230T	JMJD1C_uc001jml.2_Missense_Mutation_p.P1011T|JMJD1C_uc001jmm.2_Missense_Mutation_p.P942T|JMJD1C_uc010qiq.1_Missense_Mutation_p.P1048T|JMJD1C_uc009xpi.2_Missense_Mutation_p.P1048T|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.P267T	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1230					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GTTAAAGTTGGAGGGGAAAGA	0.468		NaN											1	0	4.87955e-14	0.005443	5.11775e-14	27	102									
JMJD1C	221037	broad.mit.edu	37	10	64974489	64974489	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:64974489G>A	uc001jmn.2	-	8	1738	c.1438C>T	c.(1438-1440)CCT>TCT	p.P480S	JMJD1C_uc001jml.2_Missense_Mutation_p.P261S|JMJD1C_uc001jmm.2_Missense_Mutation_p.P192S|JMJD1C_uc010qiq.1_Missense_Mutation_p.P298S|JMJD1C_uc009xpi.2_Missense_Mutation_p.P298S|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmp.1_Missense_Mutation_p.P192S	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	480					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					CATTCCTGAGGAAGTAAATCA	0.373		NaN											0	0	0	0.01441	0	61	190									
NEUROG3	50674	broad.mit.edu	37	10	71332454	71332454	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:71332454C>T	uc001jpp.2	-	2	504	c.346G>A	c.(346-348)GAC>AAC	p.D116N		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	116	Helix-loop-helix motif.				central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						AGCTTCGCGTCGTCTGGGAAG	0.622		NaN											0	0	0	0.001984	0	7	21									
TYSND1	219743	broad.mit.edu	37	10	71902546	71902546	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:71902546G>A	uc001jqr.2	-	3	1515	c.1361C>T	c.(1360-1362)TCA>TTA	p.S454L	TYSND1_uc001jqq.2_RNA|TYSND1_uc001jqs.2_Intron|TYSND1_uc001jqt.2_Intron	NM_173555	NP_775826	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1 isoform a	454	Serine protease.				proteolysis	peroxisome	serine-type endopeptidase activity			large_intestine(1)	1						AAGGATGCCTGAGGTCACCGA	0.642		NaN											0	0	0	0.001168	0	6	20									
SLC29A3	55315	broad.mit.edu	37	10	73082533	73082533	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:73082533G>A	uc001jrr.3	+	2	79	c.22G>A	c.(22-24)GAC>AAC	p.D8N	SLC29A3_uc001jrs.3_Missense_Mutation_p.D8N|SLC29A3_uc010qjq.1_5'UTR|SLC29A3_uc001jrt.3_5'UTR|SLC29A3_uc001jru.3_5'UTR	NM_018344	NP_060814	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (nucleoside	8	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity				0						CTCAGAGGACGACTTTCAGCA	0.597		NaN											0	0	0	0.00278	0	22	85									
NDST2	8509	broad.mit.edu	37	10	75567514	75567514	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:75567514G>C	uc001jvk.2	-	3	1437	c.633C>G	c.(631-633)CTC>CTG	p.L211L	NDST2_uc010qks.1_5'Flank|NDST2_uc010qkt.1_Silent_p.L88L|NDST2_uc009xro.2_5'Flank|NDST2_uc010qku.1_Silent_p.L88L	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	211	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					TGGGGCGTGTGAGATGCAGTA	0.552		NaN											0	0	0	0.004482	0	9	42									
ADK	132	broad.mit.edu	37	10	75960592	75960592	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:75960592G>A	uc001jwi.2	+	2	208	c.136G>A	c.(136-138)GAT>AAT	p.D46N	ADK_uc010qlb.1_Missense_Mutation_p.D46N|ADK_uc001jwj.2_Missense_Mutation_p.D29N|ADK_uc010qlc.1_Missense_Mutation_p.D29N	NM_006721	NP_006712	P55263	ADK_HUMAN	adenosine kinase isoform b	46					purine base metabolic process|purine ribonucleoside salvage	cytosol	adenosine kinase activity|ATP binding|metal ion binding|phosphotransferase activity, alcohol group as acceptor			ovary(1)|skin(1)	2	Prostate(51;0.0112)|Ovarian(15;0.148)				Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Pegademase bovine(DB00061)|Ribavirin(DB00811)	AGATTTCCTTGATAAGTAAGT	0.328		NaN											0	0	0	0.001855	0	13	42									
WAPAL	23063	broad.mit.edu	37	10	88260375	88260375	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:88260375C>T	uc001kdo.2	-	3	1067	c.625G>A	c.(625-627)GAT>AAT	p.D209N	WAPAL_uc001kdn.2_Missense_Mutation_p.D252N|WAPAL_uc009xsw.2_Missense_Mutation_p.D209N	NM_015045	NP_055860	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog	209	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			ovary(1)	1						TTCCAAGTATCATTTGTTTCC	0.378		NaN											0	0	0	0.007835	0	41	138									
LDB3	11155	broad.mit.edu	37	10	88439133	88439133	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:88439133G>A	uc001kdv.2	+	2	126	c.103G>A	c.(103-105)GGC>AGC	p.G35S	LDB3_uc010qml.1_Missense_Mutation_p.G35S|LDB3_uc010qmm.1_Missense_Mutation_p.G35S|LDB3_uc001kdu.2_Missense_Mutation_p.G35S|LDB3_uc009xsz.2_5'UTR|LDB3_uc001kdr.2_Missense_Mutation_p.G35S|LDB3_uc009xsy.2_Missense_Mutation_p.G35S|LDB3_uc001kds.2_Missense_Mutation_p.G35S|LDB3_uc001kdt.2_RNA	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	35	PDZ.					cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						GATCACACCAGGCAGCAAGGC	0.587		NaN											0	0	0	0.005443	0	26	27									
MMRN2	79812	broad.mit.edu	37	10	88696506	88696506	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:88696506C>T	uc001kea.2	-	7	2971	c.2844G>A	c.(2842-2844)AAG>AAA	p.K948K	MMRN2_uc010qmn.1_Silent_p.K591K	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	948	C1q.					extracellular space				large_intestine(1)	1						GGGTTCAGGTCTTAAACATCA	0.552		NaN											0	0	0	0.01441	0	87	65									
HTR7	3363	broad.mit.edu	37	10	92617043	92617043	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:92617043G>C	uc001kha.2	-	1	629	c.386C>G	c.(385-387)TCG>TGG	p.S129W	HTR7_uc001kgz.2_Missense_Mutation_p.S129W|HTR7_uc001khb.2_Missense_Mutation_p.S129W	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	129	Helical; Name=2; (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	CACAGCCACCGAGAGGTCGGC	0.597		NaN											0	0	0	0.008291	0	10	48									
PDE6C	5146	broad.mit.edu	37	10	95400233	95400233	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:95400233G>C	uc001kiu.3	+	13	1794	c.1656G>C	c.(1654-1656)GTG>GTC	p.V552V		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	552					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TGTACACTGTGAGGAAAGGGT	0.448		NaN											0	0	0	0.00874	0	40	113									
CYP2C9	1559	broad.mit.edu	37	10	96698472	96698472	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:96698472C>G	uc001kka.3	+	1	58	c.33C>G	c.(31-33)CTC>CTG	p.L11L	CYP2C9_uc009xut.2_Silent_p.L11L|CYP2C9_uc001kjz.2_Silent_p.L11L	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	11					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TGCTCTGTCTCTCATGTTTGC	0.478		NaN											0	0	0	0.01441	0	171	160									
ENTPD1	953	broad.mit.edu	37	10	97607265	97607265	+	Silent	SNP	C	C	T	rs149509898	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:97607265C>T	uc001klh.3	+	7	1200	c.876C>T	c.(874-876)AAC>AAT	p.N292N	ENTPD1_uc001kli.3_Silent_p.N299N|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Silent_p.N304N|ENTPD1_uc010qok.1_Silent_p.N184N|ENTPD1_uc010qol.1_Silent_p.N184N|ENTPD1_uc010qom.1_Intron|ENTPD1_uc010qon.1_Silent_p.N154N|ENTPD1_uc009xva.2_Silent_p.N154N|ENTPD1_uc009xuz.2_Intron	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	292	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		AGGTAGTGAACGTAAGTGACC	0.418		NaN											0	0	0	0.003271	0	35	100									
BLNK	29760	broad.mit.edu	37	10	97964290	97964290	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:97964290C>T	uc001kls.3	-	12	1078	c.900G>A	c.(898-900)CAG>CAA	p.Q300Q	BLNK_uc001kme.3_Silent_p.Q195Q|BLNK_uc001klt.3_Silent_p.Q191Q|BLNK_uc009xvc.2_RNA|BLNK_uc001klu.3_Silent_p.Q218Q|BLNK_uc001klv.3_Silent_p.Q195Q|BLNK_uc001klw.3_RNA|BLNK_uc001klx.3_Silent_p.Q277Q|BLNK_uc001kly.3_Silent_p.Q300Q|BLNK_uc001klz.3_RNA|BLNK_uc001kma.3_Silent_p.Q277Q|BLNK_uc001kmb.3_Silent_p.Q96Q|BLNK_uc001kmc.3_RNA|BLNK_uc001kmd.3_Silent_p.Q218Q|BLNK_uc009xvd.2_RNA	NM_013314	NP_037446	Q8WV28	BLNK_HUMAN	B-cell linker isoform 1	300					B cell differentiation|humoral immune response|inflammatory response|intracellular signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(2)	2		Colorectal(252;0.083)		Epithelial(162;7.89e-08)|all cancers(201;2.27e-06)		ATTCTTACTTCTGGGCAGGAG	0.448		NaN											0	0	0	0.01441	0	46	69									
TLL2	7093	broad.mit.edu	37	10	98144396	98144396	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:98144396G>A	uc001kml.1	-	16	2368	c.2142C>T	c.(2140-2142)TTC>TTT	p.F714F		NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	714	CUB 3.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		TGTCGGACTTGAACTCCACGC	0.637		NaN											0	0	0	0.009535	0	29	83									
TM9SF3	56889	broad.mit.edu	37	10	98336574	98336574	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:98336574C>G	uc001kmm.3	-	2	332	c.115G>C	c.(115-117)GAG>CAG	p.E39Q	TM9SF3_uc010qot.1_Missense_Mutation_p.E39Q	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	39						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		ACAACTTCCTCTTTATCTTGA	0.313		NaN											0	0	0	0.00333	0	24	62									
LOXL4	84171	broad.mit.edu	37	10	100022549	100022549	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:100022549G>A	uc001kpa.1	-	2	379	c.228C>T	c.(226-228)TTC>TTT	p.F76F		NM_032211	NP_115587	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4 precursor	76	SRCR 1.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			ovary(3)|breast(1)|skin(1)	5		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		AGGCAGCTTCGAAGCCCAGCT	0.622		NaN									OREG0020428	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010818	0	31	27									
CUTC	51076	broad.mit.edu	37	10	101514304	101514304	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:101514304G>T	uc001kqd.3	+	8	768	c.620G>T	c.(619-621)AGA>ATA	p.R207I	CUTC_uc001kqe.3_RNA	NM_015960	NP_057044	Q9NTM9	CUTC_HUMAN	cutC copper transporter homolog	207					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		ATAACAGACAGAAATCTACAA	0.363		NaN											1	0	2.80266e-47	0.01441	2.98126e-47	81	221									
ABCC2	1244	broad.mit.edu	37	10	101594192	101594192	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:101594192G>A	uc001kqf.2	+	24	3453	c.3314G>A	c.(3313-3315)TGC>TAC	p.C1105Y		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1105	ABC transmembrane type-1 2.|Helical; Name=14; (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGGATTACATGCTTCCTGGGG	0.473		NaN											0	0	0	0.01441	0	87	96									
CHUK	1147	broad.mit.edu	37	10	101959727	101959727	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:101959727C>T	uc001kqp.2	-	16	1784	c.1729_splice	c.e16+1	p.D577_splice		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		AAGTGTCTTACCTGAAGGTCT	0.348		NaN											0	0	0	0.014323	0	24	96									
MRPL43	84545	broad.mit.edu	37	10	102746534	102746534	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:102746534C>T	uc001kry.1	-	3	509	c.437G>A	c.(436-438)CGA>CAA	p.R146Q	MRPL43_uc010qpu.1_Missense_Mutation_p.R146Q|MRPL43_uc001krz.1_Intron|MRPL43_uc001ksa.1_Missense_Mutation_p.R146Q|MRPL43_uc001ksb.1_Missense_Mutation_p.R146Q|MRPL43_uc001ksd.1_Missense_Mutation_p.R146Q|MRPL43_uc001ksc.2_Missense_Mutation_p.R146Q|MRPL43_uc001kse.2_Missense_Mutation_p.R184Q|C10orf2_uc001ksg.2_5'Flank|C10orf2_uc001ksf.2_5'Flank|C10orf2_uc001ksi.2_5'Flank|C10orf2_uc010qpv.1_5'Flank|C10orf2_uc001ksh.2_5'Flank	NM_176792	NP_789762	Q8N983	RM43_HUMAN	mitochondrial ribosomal protein L43 isoform b	146					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		CTGAACCTCTCGGGGGCGTAG	0.627		NaN											0	0	0	0.001855	0	12	39									
KCNIP2	30819	broad.mit.edu	37	10	103588903	103588903	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:103588903G>A	uc001kub.2	-	4	629	c.277C>T	c.(277-279)CTG>TTG	p.L93L	KCNIP2_uc010qqg.1_5'Flank|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Silent_p.V14V|KCNIP2_uc001ktz.2_Silent_p.L48L|KCNIP2_uc009xwu.2_Silent_p.L43L|KCNIP2_uc009xwv.2_Silent_p.L43L|KCNIP2_uc001kuc.2_Silent_p.L108L|KCNIP2_uc001kue.2_Silent_p.L75L|KCNIP2_uc001kud.2_Silent_p.L43L|KCNIP2_uc001kuf.2_Silent_p.L43L|KCNIP2_uc001kua.2_Silent_p.V14V|KCNIP2_uc009xww.2_RNA|KCNIP2_uc010qqh.1_Silent_p.L48L|KCNIP2_uc010qqi.1_Silent_p.L43L	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	93	EF-hand 1; degenerate.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		AGCTGCTCCAGACCCTCAGGC	0.617		NaN											0	0	0	0.001168	0	5	22									
CNNM2	54805	broad.mit.edu	37	10	104679815	104679815	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:104679815C>T	uc001kwm.2	+	1	1702	c.1578C>T	c.(1576-1578)TTC>TTT	p.F526F	CNNM2_uc001kwn.2_Silent_p.F526F|CNNM2_uc001kwl.2_Silent_p.F526F	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	526	CBS 2.				ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ACTTTGTTTTCAATGACACCA	0.453		NaN											0	0	0	0.01441	0	51	122									
ADD3	120	broad.mit.edu	37	10	111881975	111881975	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:111881975G>A	uc001kyt.3	+	10	1382	c.1068G>A	c.(1066-1068)GTG>GTA	p.V356V	ADD3_uc001kys.3_Silent_p.V356V|ADD3_uc001kyu.2_Silent_p.V356V|ADD3_uc001kyv.2_Silent_p.V356V|ADD3_uc001kyw.2_Silent_p.V356V|ADD3_uc001kyx.2_5'Flank	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma) isoform a	356						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			ovary(2)|skin(2)|large_intestine(1)	5		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GAGGAGGTGTGAATATGGGTT	0.448		NaN											0	0	0	0.012213	0	30	70									
ACSL5	51703	broad.mit.edu	37	10	114186017	114186017	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:114186017C>T	uc001kzs.2	+	19	1880	c.1739C>T	c.(1738-1740)TCA>TTA	p.S580L	ACSL5_uc001kzt.2_Missense_Mutation_p.S580L|ACSL5_uc001kzu.2_Missense_Mutation_p.S636L|ACSL5_uc009xxz.2_Missense_Mutation_p.S580L|ACSL5_uc010qrj.1_Missense_Mutation_p.S362L	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	580	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		TTTCCATAGTCATCCTTAGTA	0.433		NaN											0	0	0	0.008361	0	29	81									
NRAP	4892	broad.mit.edu	37	10	115402797	115402797	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:115402797C>A	uc001laj.2	-	12	1275	c.1111G>T	c.(1111-1113)GTG>TTG	p.V371L	NRAP_uc001lak.2_Intron|NRAP_uc001lal.3_Missense_Mutation_p.V371L	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	371	Nebulin 8.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TTATACTCCACCTTGGAAATC	0.388		NaN											1	0	1.66031e-10	0.003954	1.72965e-10	26	85									
DCLRE1A	9937	broad.mit.edu	37	10	115609522	115609522	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:115609522C>T	uc001law.2	-	2	2260	c.1342G>A	c.(1342-1344)GAA>AAA	p.E448K		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	448	Nuclear focus formation.				cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		GATGATTCTTCAATTACCTGT	0.388		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.013114	0	47	61									
AFAP1L2	84632	broad.mit.edu	37	10	116062228	116062228	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:116062228C>T	uc001lbn.2	-	12	1601	c.1300G>A	c.(1300-1302)GAA>AAA	p.E434K	AFAP1L2_uc001lbo.2_Missense_Mutation_p.E434K|AFAP1L2_uc010qse.1_Missense_Mutation_p.E487K|AFAP1L2_uc001lbp.2_Missense_Mutation_p.E462K|AFAP1L2_uc001lbr.1_Missense_Mutation_p.E434K|AFAP1L2_uc001lbm.2_5'Flank|AFAP1L2_uc010qsd.1_5'UTR|AFAP1L2_uc001lbq.1_5'Flank	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	434	PH 2.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TGGCCCATTTCCTCGGAAGAC	0.607		NaN											0	0	0	0.005443	0	22	66									
FAM160B1	57700	broad.mit.edu	37	10	116593033	116593033	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:116593033C>T	uc001lcb.2	+	3	501	c.166C>T	c.(166-168)CTG>TTG	p.L56L	FAM160B1_uc001lcc.2_Silent_p.L56L	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	56										lung(1)	1						TCCATCGCATCTGGAACAGAT	0.353		NaN											0	0	0	0.012319	0	23	67									
RAB11FIP2	22841	broad.mit.edu	37	10	119799772	119799772	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:119799772G>A	uc001ldj.1	-	2	1098	c.658C>T	c.(658-660)CAG>TAG	p.Q220*	RAB11FIP2_uc009xyz.1_Nonsense_Mutation_p.Q220*	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	220					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		GAGAGTCGCTGAGGACCCAAG	0.438		NaN											0	0	0	0.004656	0	27	262									
PRDX3	10935	broad.mit.edu	37	10	120928689	120928689	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:120928689C>T	uc001lec.2	-	6	760	c.717G>A	c.(715-717)ACG>ACA	p.T239T		NM_006793	NP_006784	P30048	PRDX3_HUMAN	peroxiredoxin 3 isoform a precursor	239					cell redox homeostasis|hydrogen peroxide catabolic process|mitochondrion organization|myeloid cell differentiation|negative regulation of kinase activity|positive regulation of cell proliferation|positive regulation of NF-kappaB transcription factor activity|regulation of mitochondrial membrane potential|response to lipopolysaccharide	early endosome|mitochondrion	alkyl hydroperoxide reductase activity|caspase inhibitor activity|peroxidase activity|peroxiredoxin activity|protein C-terminus binding|protein kinase binding				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0245)		AAAAACCTACCGTAGGAGAAT	0.512		NaN											0	0	0	0.005443	0	26	73									
BAG3	9531	broad.mit.edu	37	10	121411190	121411190	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:121411190G>A	uc001lem.2	+	1	309	c.3G>A	c.(1-3)ATG>ATA	p.M1I	BAG3_uc001lel.2_Missense_Mutation_p.M1I	NM_004281	NP_004272	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	1					anti-apoptosis|apoptosis|protein folding	cytosol				ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		AACCCAGCATGAGCGCCGCCA	0.756		NaN											0	0	0	0.013537	0	11	6									
FGFR2	2263	broad.mit.edu	37	10	123239498	123239498	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:123239498G>A	uc010qtk.1	-	19	2986	c.2339C>T	c.(2338-2340)TCA>TTA	p.S780L	FGFR2_uc010qtg.1_Missense_Mutation_p.S668L|FGFR2_uc010qth.1_Missense_Mutation_p.S665L|FGFR2_uc010qti.1_Intron|FGFR2_uc010qtj.1_Missense_Mutation_p.S781L|FGFR2_uc010qtl.1_Missense_Mutation_p.S664L|FGFR2_uc010qtm.1_Missense_Mutation_p.S663L|FGFR2_uc001lfg.3_Missense_Mutation_p.S388L|FGFR2_uc001lfk.1_RNA	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	780	Cytoplasmic (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	GTAACTAGGTGAATACTGTTC	0.443		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.013726	0	33	87									
FGFR2	2263	broad.mit.edu	37	10	123325072	123325072	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:123325072C>T	uc010qtk.1	-	3	903	c.256G>A	c.(256-258)GTG>ATG	p.V86M	FGFR2_uc010qtg.1_Missense_Mutation_p.V86M|FGFR2_uc010qth.1_Intron|FGFR2_uc010qti.1_Intron|FGFR2_uc010qtj.1_Missense_Mutation_p.V86M|FGFR2_uc010qtl.1_Missense_Mutation_p.V86M|FGFR2_uc010qtm.1_Intron|FGFR2_uc001lfl.3_Missense_Mutation_p.V86M|FGFR2_uc001lfm.2_Intron|FGFR2_uc001lfn.3_Intron|FGFR2_uc010qtn.1_Missense_Mutation_p.V105M|FGFR2_uc010qto.1_Intron|FGFR2_uc001lfo.1_Missense_Mutation_p.V105M|FGFR2_uc010qtp.1_Missense_Mutation_p.V105M|FGFR2_uc010qtq.1_Missense_Mutation_p.V105M	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	86	Ig-like C2-type 1.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CCAATAAGCACTGTCCTATTG	0.552		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.005443	0	26	80									
LHPP	64077	broad.mit.edu	37	10	126172787	126172787	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:126172787C>T	uc001lhs.1	+	2	225	c.205C>T	c.(205-207)CAG>TAG	p.Q69*	LHPP_uc001lht.1_Nonsense_Mutation_p.Q69*|LHPP_uc009yai.1_Nonsense_Mutation_p.Q69*	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	69					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		GGGGCAGCTTCAGAGGCTGGG	0.627		NaN											0	0	0	0.010729	0	7	34									
LHPP	64077	broad.mit.edu	37	10	126301921	126301921	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:126301921G>C	uc001lhs.1	+	7	825	c.805G>C	c.(805-807)GAC>CAC	p.D269H	LHPP_uc001lht.1_3'UTR|LHPP_uc009yai.1_Missense_Mutation_p.D186H|LHPP_uc009yaj.1_RNA	NM_022126	NP_071409	Q9H008	LHPP_HUMAN	phospholysine phosphohistidine inorganic	269					protein dephosphorylation	cytosol|nucleus	inorganic diphosphatase activity|magnesium ion binding|phosphohistidine phosphatase activity|protein homodimerization activity				0		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.163)|Colorectal(40;0.187)		GCAGCACGCCGACAAGTGATG	0.388		NaN											0	0	0	0.00333	0	22	26									
ZRANB1	54764	broad.mit.edu	37	10	126670348	126670348	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:126670348G>A	uc001lic.2	+	6	1869	c.1498G>A	c.(1498-1500)GAA>AAA	p.E500K	ZRANB1_uc010qug.1_Missense_Mutation_p.E526K	NM_017580	NP_060050	Q9UGI0	ZRAN1_HUMAN	zinc finger, RAN-binding domain containing 1	500	OTU.|TRAF-binding.				positive regulation of Wnt receptor signaling pathway|protein K63-linked deubiquitination|Wnt receptor signaling pathway	aggresome|centrosome|intermediate filament cytoskeleton|nucleolus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.113)|COAD - Colon adenocarcinoma(40;0.119)		TTCCTTGAGAGAAGAACAGTG	0.378		NaN											0	0	0	0.006122	0	17	51									
DHX32	55760	broad.mit.edu	37	10	127525285	127525285	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:127525285C>T	uc001ljf.1	-	11	2694	c.2203G>A	c.(2203-2205)GAA>AAA	p.E735K	BCCIP_uc001ljd.3_Intron|DHX32_uc001lje.1_Missense_Mutation_p.E359K|DHX32_uc001ljg.1_Missense_Mutation_p.E735K|BCCIP_uc010qui.1_Intron|BCCIP_uc001ljc.3_Intron|BCCIP_uc010quj.1_Intron	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	735						mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGTTCAGTTTCAGGGCACGTC	0.498		NaN											0	0	0	0.00245	0	15	38									
GLRX3	10539	broad.mit.edu	37	10	131964842	131964842	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:131964842G>A	uc001lkm.1	+	5	572	c.550G>A	c.(550-552)GAT>AAT	p.D184N	GLRX3_uc001lkn.1_Missense_Mutation_p.D184N|GLRX3_uc001lko.2_RNA	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	184	Glutaredoxin 1.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		TATCTTCTCAGATGAAGAGGT	0.383		NaN											0	0	0	0.00278	0	24	100									
DPYSL4	10570	broad.mit.edu	37	10	134015509	134015509	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:134015509A>C	uc009ybb.2	+	11	1324	c.1170A>C	c.(1168-1170)AAA>AAC	p.K390N		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	390					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		ATGCTGCCAAAATCTTCAATT	0.557		NaN											0	0	0	0.00333	0	23	126									
PWWP2B	170394	broad.mit.edu	37	10	134218707	134218707	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:134218707G>A	uc001lll.3	+	2	732	c.703G>A	c.(703-705)GAG>AAG	p.E235K	PWWP2B_uc009ybe.2_Missense_Mutation_p.E235K	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	235											0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		GAGCAAGAGGGAGAGGCGCGA	0.716		NaN											0	0	0	0.004672	0	3	7									
C10orf91	170393	broad.mit.edu	37	10	134261557	134261557	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:134261557G>A	uc001llm.2	+	3	470	c.430G>A	c.(430-432)GAA>AAA	p.E144K		NM_173541	NP_775812	Q5T1B1	CJ091_HUMAN	hypothetical protein LOC170393	144										ovary(1)	1		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;6.95e-05)|Epithelial(32;0.000142)|all cancers(32;0.000162)		TGCGGCCTTCGAAGCCTGAAG	0.662		NaN											0	0	0	0.00333	0	22	109									
INPP5A	3632	broad.mit.edu	37	10	134511403	134511403	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:134511403C>T	uc001llp.2	+	6	702	c.454C>T	c.(454-456)CCG>TCG	p.P152S	INPP5A_uc001llo.1_Missense_Mutation_p.P152S|INPP5A_uc001llq.2_Missense_Mutation_p.P104S	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	152				PQDYFPECKWSRKGFIRTRWC -> RRLLPRVQMVKKRLHP DEVV (in Ref. 5; CAA83500).	cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		GGAGAAGTTTCCGCAGGACTA	0.498		NaN											0	0	0	0.010729	0	10	34									
HRAS	3265	broad.mit.edu	37	11	533785	533785	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:533785C>T	uc001lpv.2	-	3	459	c.271G>A	c.(271-273)GAG>AAG	p.E91K	HRAS_uc010qvw.1_Missense_Mutation_p.E91K|HRAS_uc010qvx.1_Missense_Mutation_p.E91K|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	91					activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TGGATGTCCTCAAAAGACTTG	0.657		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.010504	0	20	35									
RASSF7	8045	broad.mit.edu	37	11	563424	563424	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:563424C>T	uc001lqc.2	+	5	1015	c.980C>T	c.(979-981)TCC>TTC	p.S327F	C11orf35_uc001lpx.2_5'Flank|RASSF7_uc001lqa.2_3'UTR|RASSF7_uc001lqb.2_3'UTR|RASSF7_uc001lqd.2_Intron	NM_003475	NP_003466	Q02833	RASF7_HUMAN	Ras association (RalGDS/AF-6) domain family	327					regulation of transcription, DNA-dependent|signal transduction	nucleus	DNA binding|protein binding			skin(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGAGAGGAGTCCCTCCTGGGC	0.697		NaN											0	0	0	0.001168	0	5	12									
PHRF1	57661	broad.mit.edu	37	11	597514	597514	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:597514G>A	uc001lqe.2	+	8	969	c.838G>A	c.(838-840)GAG>AAG	p.E280K	PHRF1_uc010qwc.1_Missense_Mutation_p.E280K|PHRF1_uc010qwd.1_Missense_Mutation_p.E279K|PHRF1_uc010qwe.1_Missense_Mutation_p.E276K|PHRF1_uc009ybz.1_Missense_Mutation_p.E71K	NM_020901	NP_065952	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	280	Arg-rich.						RNA polymerase binding|zinc ion binding				0						ACGGCAGAGTGAGAGAGTGAG	0.662		NaN											0	0	0	0.000602	0	5	17									
CDHR5	53841	broad.mit.edu	37	11	617418	617419	+	Missense_Mutation	DNP	TC	TC	AT	rs76054644		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:617418_617419TC>AT	uc001lqj.2	-	15	2575_2576	c.2470_2471GA>AT	c.(2470-2472)GAG>ATG	p.E824M	IRF7_uc009ycb.2_5'Flank|IRF7_uc010qwf.1_5'Flank|IRF7_uc001lqf.2_5'Flank|IRF7_uc010qwg.1_5'Flank|IRF7_uc001lqg.2_5'Flank|IRF7_uc001lqh.2_5'Flank|IRF7_uc001lqi.2_5'Flank|IRF7_uc010qwh.1_5'Flank|CDHR5_uc001lqk.2_Missense_Mutation_p.E630M|CDHR5_uc009ycc.2_Missense_Mutation_p.E658M|CDHR5_uc009ycd.2_Missense_Mutation_p.E818M|CDHR5_uc001lql.2_Missense_Mutation_p.E824M	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	824	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						GCCCTCGCCCTCATCGCCGCTG	0.688		NaN											0	0	0	0.004672	0	4	11									
TMEM80	283232	broad.mit.edu	37	11	702971	702971	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:702971G>A	uc001lqr.2	+	5	465	c.328G>A	c.(328-330)GAG>AAG	p.E110K	TMEM80_uc001lqs.2_Missense_Mutation_p.E102K|TMEM80_uc010qwi.1_Missense_Mutation_p.E110K	NM_001042463	NP_001035928	Q96HE8	TMM80_HUMAN	transmembrane protein 80 isoform 2	110						integral to membrane					0		all_cancers(49;5.11e-06)|all_epithelial(84;0.00143)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.44e-27)|Epithelial(43;2.29e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.19e-20)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GACAGAGGCTGAGAGGCCGCT	0.692		NaN											0	0	0	0.010729	0	11	36									
TMEM80	283232	broad.mit.edu	37	11	703075	703075	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:703075C>T	uc001lqr.2	+	5	569	c.432C>T	c.(430-432)CTC>CTT	p.L144L	TMEM80_uc001lqs.2_Silent_p.L136L|TMEM80_uc010qwi.1_Silent_p.L144L	NM_001042463	NP_001035928	Q96HE8	TMM80_HUMAN	transmembrane protein 80 isoform 2	144	Helical; (Potential).					integral to membrane					0		all_cancers(49;5.11e-06)|all_epithelial(84;0.00143)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.44e-27)|Epithelial(43;2.29e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.19e-20)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACTGGGCCCTCAGCGCCACGC	0.701		NaN											0	0	0	0.001984	0	7	35									
MUC2	4583	broad.mit.edu	37	11	1081800	1081800	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1081800G>A	uc001lsx.1	+	13	1755	c.1728G>A	c.(1726-1728)CTG>CTA	p.L576L		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	576	VWFD 2.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCTGCTCCCTGAACATCGAGA	0.677		NaN											0	0	0	0.006122	0	16	20									
MUC5B	727897	broad.mit.edu	37	11	1276623	1276623	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1276623G>A	uc009ycr.1	+	59	17038	c.16912G>A	c.(16912-16914)GAG>AAG	p.E5638K	MUC5B_uc001ltb.2_Missense_Mutation_p.E5304K	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5301	VWFD 4.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGTCTTTGCTGAGTGCCACAA	0.597		NaN											0	0	0	0.000602	0	4	5									
SYT8	90019	broad.mit.edu	37	11	1856335	1856335	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1856335G>A	uc001lue.1	+	2	170	c.42G>A	c.(40-42)AAG>AAA	p.K14K	SYT8_uc010qxb.1_5'UTR|SYT8_uc001lud.2_Silent_p.K14K|SYT8_uc001luf.1_5'UTR|SYT8_uc009ydb.1_5'UTR	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	14	Extracellular (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGGGTAGAAAGATGGGGCACC	0.657		NaN											0	0	0	0.001168	0	6	34									
SYT8	90019	broad.mit.edu	37	11	1856355	1856355	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1856355C>G	uc001lue.1	+	2	190	c.62C>G	c.(61-63)TCT>TGT	p.S21C	SYT8_uc010qxb.1_Missense_Mutation_p.S7C|SYT8_uc001lud.2_Missense_Mutation_p.S21C|SYT8_uc001luf.1_Missense_Mutation_p.S7C|SYT8_uc009ydb.1_Missense_Mutation_p.S7C	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	21	Extracellular (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCACCAGTCTCTCCCAGTGCC	0.662		NaN											0	0	0	0.000602	0	5	37									
SYT8	90019	broad.mit.edu	37	11	1856543	1856543	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:1856543A>C	uc001lue.1	+	3	282	c.154A>C	c.(154-156)ATT>CTT	p.I52L	SYT8_uc010qxb.1_Missense_Mutation_p.I38L|SYT8_uc001lud.2_Missense_Mutation_p.I52L|SYT8_uc001luf.1_Missense_Mutation_p.I38L|SYT8_uc009ydb.1_Missense_Mutation_p.I38L	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	52	Helical; Signal-anchor for type III membrane protein; (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CTGGGCTCTCATTGCCGGCGC	0.677		NaN											0	0	0	0.003954	0	20	42									
NUP98	4928	broad.mit.edu	37	11	3707310	3707310	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:3707310G>C	uc001lyh.2	-	29	4860	c.4569C>G	c.(4567-4569)CTC>CTG	p.L1523L	NUP98_uc001lyi.2_Intron|NUP98_uc001lyg.2_Silent_p.L488L	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1540					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		ACTGCGCTGAGAGATGGGTGT	0.557		NaN	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.004007	0	17	82									
OR51D1	390038	broad.mit.edu	37	11	4661061	4661061	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:4661061C>G	uc010qyk.1	+	1	41	c.41C>G	c.(40-42)TCA>TGA	p.S14*		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGCCACTTCAAATGGAAAT	0.473		NaN											0	0	0	0.009535	0	29	145									
OR51L1	119682	broad.mit.edu	37	11	5020915	5020915	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:5020915G>C	uc010qyu.1	+	1	703	c.703G>C	c.(703-705)GAG>CAG	p.E235Q		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATCTCGTGAAGAGCAGCTAAA	0.423		NaN											0	0	0	0.00499	0	18	82									
OR52A1	23538	broad.mit.edu	37	11	5173165	5173165	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:5173165C>G	uc010qyy.1	-	1	435	c.435G>C	c.(433-435)CAG>CAC	p.Q145H		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGTTCCTATCTGAATGACAA	0.483		NaN											0	0	0	0.00278	0	23	51									
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5624476	5624476	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:5624476G>A	uc001mbf.2	+	2	262	c.18G>A	c.(16-18)AGG>AGA	p.R6R	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_5'UTR|TRIM6_uc010qzj.1_Intron|TRIM6_uc001mbc.1_5'UTR|TRIM6_uc001mbe.2_Intron|TRIM6_uc010qzk.1_Intron|TRIM6_uc010qzl.1_Intron|TRIM6_uc001mbd.2_Silent_p.R6R|TRIM6_uc001mbg.1_5'Flank|TRIM6_uc009yep.1_5'Flank	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	6						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		ATCTACCTAGGATTCTACAGG	0.473		NaN											0	0	0	0.003954	0	25	39									
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5624860	5624860	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:5624860C>G	uc001mbf.2	+	2	646	c.402C>G	c.(400-402)CTC>CTG	p.L134L	HBG2_uc001mak.1_Intron|TRIM6_uc009yeo.1_Intron|TRIM6_uc010qzj.1_5'UTR|TRIM6_uc001mbc.1_Silent_p.L106L|TRIM6_uc001mbe.2_5'UTR|TRIM6_uc010qzk.1_Intron|TRIM6_uc010qzl.1_Intron|TRIM6_uc001mbd.2_Silent_p.L134L|TRIM6_uc001mbg.1_5'Flank|TRIM6_uc009yep.1_5'Flank	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	134						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		AACTGCAGCTCTTCTGTCAGG	0.557		NaN											0	0	0	0.009718	0	40	65									
TAF10	6881	broad.mit.edu	37	11	6632638	6632638	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6632638C>T	uc001mej.1	-	3	458	c.433G>A	c.(433-435)GAG>AAG	p.E145K		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	145					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCTGAGGCCTCAAAGCCAGCA	0.493		NaN											0	0	0	0.012319	0	21	18									
TAF10	6881	broad.mit.edu	37	11	6632654	6632654	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6632654C>T	uc001mej.1	-	3	442	c.417G>A	c.(415-417)CTG>CTA	p.L139L		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	139					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CAGCACGGTTCAGGTAGTAAC	0.502		NaN											0	0	0	0.007413	0	18	15									
DCHS1	8642	broad.mit.edu	37	11	6648801	6648801	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6648801C>G	uc001mem.1	-	14	5879	c.5469G>C	c.(5467-5469)CTG>CTC	p.L1823L		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1823	Cadherin 17.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTCTATCCTCAGCTGGAAAG	0.577		NaN											0	0	0	0.006214	0	9	16									
DCHS1	8642	broad.mit.edu	37	11	6661224	6661225	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6661224_6661225CC>TA	uc001mem.1	-	2	2030_2031	c.1620_1621GG>TA	c.(1618-1623)TTGGAA>TTTAAA	p.540_541LE>FK		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	540_541	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCTGAGGTTCCAACTCATAGT	0.569		NaN											0	0	0	0.004672	0	11	33									
DCHS1	8642	broad.mit.edu	37	11	6661230	6661230	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6661230C>T	uc001mem.1	-	2	2025	c.1615G>A	c.(1615-1617)GAG>AAG	p.E539K		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	539	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGTTCCAACTCATAGTCCAGT	0.582		NaN											0	0	0	0.003163	0	11	33									
MRPL17	63875	broad.mit.edu	37	11	6704022	6704022	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:6704022C>T	uc001men.2	-	2	304	c.199G>A	c.(199-201)GAC>AAC	p.D67N		NM_022061	NP_071344	Q9NRX2	RM17_HUMAN	mitochondrial ribosomal protein L17 precursor	67					translation	ribosome	protein domain specific binding|structural constituent of ribosome				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCGTTAGTGTCTCCCAGCTTC	0.532		NaN											0	0	0	0.005443	0	23	9									
OLFML1	283298	broad.mit.edu	37	11	7509610	7509610	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:7509610G>A	uc001mfi.2	+	2	734	c.382G>A	c.(382-384)GAA>AAA	p.E128K	uc001mff.1_Intron|OLFML1_uc001mfh.1_Missense_Mutation_p.E128K|OLFML1_uc010raz.1_Intron|OLFML1_uc010rba.1_Missense_Mutation_p.E128K	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	128	Potential.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CCAAGAAGCTGAAGAAGAGAA	0.458		NaN											0	0	0	0.00308	0	7	15									
EIF3F	8665	broad.mit.edu	37	11	8014480	8014480	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:8014480G>A	uc001mfw.2	+	4	595	c.562G>A	c.(562-564)GAG>AAG	p.E188K	EIF3F_uc010rbj.1_Missense_Mutation_p.E39K	NM_003754	NP_003745	O00303	EIF3F_HUMAN	eukaryotic translation initiation factor 3,	188	MPN.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(1)	1				Epithelial(150;1.44e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTGATCCACGAGTACTACAG	0.542		NaN											0	0	0	0.01441	0	62	46									
SCUBE2	57758	broad.mit.edu	37	11	9088303	9088303	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:9088303C>A	uc001mhh.1	-	6	781	c.701G>T	c.(700-702)GGC>GTC	p.G234V	SCUBE2_uc001mhi.1_Missense_Mutation_p.G234V|SCUBE2_uc001mhj.1_Missense_Mutation_p.G234V	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	234	EGF-like 5 (Potential).					extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GCACTCTGGGCCATCGGCTGT	0.537		NaN											1	0	5.35267e-07	0.007413	5.50488e-07	16	10									
IPO7	10527	broad.mit.edu	37	11	9424908	9424908	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:9424908G>C	uc001mho.2	+	2	298	c.156G>C	c.(154-156)GTG>GTC	p.V52V		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	52	Importin N-terminal.				interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		ATTTACCTGTGAGACAGGCAG	0.378		NaN											0	0	0	0.007413	0	18	49									
WEE1	7465	broad.mit.edu	37	11	9597434	9597434	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:9597434G>A	uc001mhs.2	+	2	830	c.577_splice	c.e2-1	p.S193_splice	WEE1_uc001mht.2_Splice_Site|WEE1_uc001mhu.2_5'UTR	NM_003390	NP_003381	P30291	WEE1_HUMAN	WEE1 tyrosine kinase isoform 1						blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		TCTTTCCCTAGAGTTTGCTCT	0.413		NaN											0	0	0	0.006214	0	10	56									
WEE1	7465	broad.mit.edu	37	11	9598771	9598771	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:9598771G>A	uc001mhs.2	+	5	1355	c.1102G>A	c.(1102-1104)GAA>AAA	p.E368K	WEE1_uc001mht.2_Missense_Mutation_p.E154K|WEE1_uc001mhu.2_Missense_Mutation_p.E154K	NM_003390	NP_003381	P30291	WEE1_HUMAN	WEE1 tyrosine kinase isoform 1	368	Protein kinase.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	5				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		TGCGTGGGCAGAAGATGATCA	0.373		NaN											0	0	0	0.003954	0	24	138									
EIF4G2	1982	broad.mit.edu	37	11	10822517	10822517	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:10822517G>A	uc001mjc.2	-	15	1948	c.1531C>T	c.(1531-1533)CTG>TTG	p.L511L	EIF4G2_uc001mjb.2_Silent_p.L305L|EIF4G2_uc009ygf.2_Silent_p.L305L|EIF4G2_uc001mjd.2_Silent_p.L473L|EIF4G2_uc001mjf.1_Silent_p.L267L	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	511					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		ACCTGTCCCAGAGGTGGTGTT	0.413		NaN											0	0	0	0.004878	0	38	134									
PLEKHA7	144100	broad.mit.edu	37	11	16838617	16838617	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:16838617G>C	uc001mmo.2	-	11	1611	c.1596C>G	c.(1594-1596)TTC>TTG	p.F532L	PLEKHA7_uc010rcu.1_Missense_Mutation_p.F532L|PLEKHA7_uc010rcv.1_Missense_Mutation_p.F106L|PLEKHA7_uc001mmn.2_Missense_Mutation_p.F240L	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	532					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TGCCGTGCCGGAACTGCTGGC	0.677		NaN											0	0	0	0.010729	0	11	20									
PIK3C2A	5286	broad.mit.edu	37	11	17121480	17121480	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:17121480G>C	uc001mmq.3	-	25	4111	c.4045C>G	c.(4045-4047)CAA>GAA	p.Q1349E	PIK3C2A_uc009ygu.1_5'UTR|PIK3C2A_uc010rcw.1_Missense_Mutation_p.Q969E|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1349	PI3K/PI4K.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TTCAAATCTTGAATACTTGTA	0.333		NaN											0	0	0	0.014323	0	22	88									
SAA4	6291	broad.mit.edu	37	11	18253209	18253209	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:18253209C>T	uc001mny.2	-	4	329	c.233G>A	c.(232-234)CGT>CAT	p.R78H		NM_006512	NP_006503	P35542	SAA4_HUMAN	serum amyloid A4, constitutive precursor	78					acute-phase response	high-density lipoprotein particle					0						GACCCTGGAACGGCTGCAACC	0.488		NaN											0	0	0	0.00308	0	8	47									
CSRP3	8048	broad.mit.edu	37	11	19204293	19204293	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:19204293A>T	uc001mpk.2	-	6	626	c.509T>A	c.(508-510)GTT>GAT	p.V170D		NM_003476	NP_003467	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3	170	LIM zinc-binding 2.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0						GGCATAGCAAACTGTGAATGA	0.428		NaN											0	0	0	0.00333	0	24	65									
FANCF	2188	broad.mit.edu	37	11	22646239	22646239	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:22646239G>A	uc001mql.1	-	1	1149	c.1118C>T	c.(1117-1119)TCT>TTT	p.S373F		NM_022725	NP_073562	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	373					DNA repair	nucleoplasm	protein binding			skin(1)	1						TGCCTATACAGAACTGAGGCC	0.383		NaN	N|F			AML|leukemia		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.010771	0	42	56									
GAS2	2620	broad.mit.edu	37	11	22707331	22707331	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:22707331C>T	uc009yie.2	+	3	569	c.263C>T	c.(262-264)ACA>ATA	p.T88I	GAS2_uc001mqm.2_Missense_Mutation_p.T88I|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.T88I	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	88	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						AACAAGCCCACAAAGGTAAAA	0.358		NaN											0	0	0	0.00632	0	29	32									
LUZP2	338645	broad.mit.edu	37	11	25004745	25004745	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:25004745C>A	uc001mqs.2	+	9	905	c.671C>A	c.(670-672)CCC>CAC	p.P224H	LUZP2_uc009yif.2_Missense_Mutation_p.P138H|LUZP2_uc009yig.2_Missense_Mutation_p.P182H	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	224	Poly-Pro.					extracellular region				ovary(1)|skin(1)	2						CAGCCTCCTCCCCCTTTGAGT	0.448		NaN											1	0	4.41824e-40	0.01441	4.69519e-40	82	80									
ANO3	63982	broad.mit.edu	37	11	26465320	26465320	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:26465320G>A	uc001mqt.3	+	3	395	c.250G>A	c.(250-252)GAG>AAG	p.E84K	ANO3_uc010rdr.1_Missense_Mutation_p.E68K	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	84	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGTTAATACTGAGGAGAATAA	0.338		NaN											0	0	0	0.010729	0	10	28									
NAT10	55226	broad.mit.edu	37	11	34167693	34167693	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:34167693G>C	uc001mvk.2	+	29	3276	c.3032G>C	c.(3031-3033)AGA>ACA	p.R1011T	NAT10_uc010ren.1_Missense_Mutation_p.R939T	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	1011	Lys-rich.|Required for localization to the nucleolus and midbody.					nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				TTGAAGAACAGAGAGACAAAG	0.358		NaN											0	0	0	0.004672	0	3	15									
EHF	26298	broad.mit.edu	37	11	34680084	34680084	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:34680084G>A	uc001mvr.1	+	8	723	c.612G>A	c.(610-612)CCG>CCA	p.P204P	EHF_uc009yke.1_Silent_p.P181P|EHF_uc009ykf.1_Silent_p.P207P	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	204					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			CATCAGACCCGAGAGGGACTC	0.468		NaN											0	0	0	0.01441	0	50	33									
CRY2	1408	broad.mit.edu	37	11	45889168	45889168	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:45889168G>C	uc010rgn.1	+	6	832	c.810G>C	c.(808-810)TGG>TGC	p.W270C	CRY2_uc009ykw.2_Missense_Mutation_p.W188C|CRY2_uc010rgo.1_5'UTR	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like) isoform 1	249	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			central_nervous_system(1)	1						TGTAGGCCTGGGTTGCCAACT	0.433		NaN											0	0	0	0.005443	0	26	75									
AMBRA1	55626	broad.mit.edu	37	11	46563761	46563761	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:46563761G>A	uc010rgu.1	-	7	2166	c.1806C>T	c.(1804-1806)GTC>GTT	p.V602V	AMBRA1_uc010rgt.1_Silent_p.V168V|AMBRA1_uc009ylc.1_Silent_p.V602V|AMBRA1_uc001ncu.1_Silent_p.V512V|AMBRA1_uc001ncv.2_Silent_p.V512V|AMBRA1_uc001ncw.2_Silent_p.V512V|AMBRA1_uc001ncx.2_Silent_p.V602V	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	602	Ser-rich.				autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		AGGAGCTGGGGACCTGCCAAG	0.582		NaN											0	0	0	0.006214	0	8	28									
F2	2147	broad.mit.edu	37	11	46749600	46749600	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:46749600C>T	uc001ndf.3	+	10	1228	c.1185C>T	c.(1183-1185)CTC>CTT	p.L395L	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	395	Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	GGGCCAGCCTCATCAGTGACC	0.627		NaN											0	0	0	0.009096	0	4	12									
LRP4	4038	broad.mit.edu	37	11	46890629	46890629	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:46890629C>T	uc001ndn.3	-	32	4893	c.4747G>A	c.(4747-4749)GAC>AAC	p.D1583N	uc001ndl.2_Intron	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1583	Extracellular (Potential).|LDL-receptor class B 20.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		GAGTATTTGTCAACACGCTGG	0.507		NaN											0	0	0	0.010504	0	21	35									
MYBPC3	4607	broad.mit.edu	37	11	47354825	47354825	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:47354825G>A	uc001nfa.3	-	29	3305	c.3250C>T	c.(3250-3252)CTG>TTG	p.L1084L		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	1083	Fibronectin type-III 3.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		TTCCACTCCAGAGCCACATTA	0.617		NaN											0	0	0	0.00308	0	7	1									
SLC39A13	91252	broad.mit.edu	37	11	47433961	47433961	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:47433961G>A	uc009ylq.2	+	4	651	c.480G>A	c.(478-480)CTG>CTA	p.L160L	SLC39A13_uc001nfd.2_Silent_p.L160L|SLC39A13_uc001nfe.1_RNA|SLC39A13_uc001nff.3_Silent_p.L160L|SLC39A13_uc001nfg.3_Silent_p.L160L	NM_001128225	NP_001121697	Q96H72	S39AD_HUMAN	solute carrier family 39 (zinc transporter),	160	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity				0				Lung(87;0.0936)		CTGGCATCCTGACCTTCCTGG	0.562		NaN									OREG0020959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	12	22									
AGBL2	79841	broad.mit.edu	37	11	47721019	47721019	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:47721019C>T	uc001ngg.2	-	7	773	c.673G>A	c.(673-675)GTT>ATT	p.V225I	AGBL2_uc010rhq.1_Missense_Mutation_p.V187I|AGBL2_uc001ngh.1_Missense_Mutation_p.V169I	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	225					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						TGATAGACAACTGTTCCTTTT	0.333		NaN											0	0	0	0.014323	0	21	74									
OR8J3	81168	broad.mit.edu	37	11	55904807	55904807	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:55904807G>C	uc010riz.1	-	1	388	c.388C>G	c.(388-390)CTG>GTG	p.L130V		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					ATGTAGAGCAGAGGGTTACAA	0.507		NaN											0	0	0	0.005443	0	20	105									
OR5T2	219464	broad.mit.edu	37	11	56000467	56000467	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:56000467G>C	uc010rjc.1	-	1	195	c.195C>G	c.(193-195)ATC>ATG	p.I65M		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	65	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GGAAGAAGAAGATAGTCTGCA	0.388		NaN											0	0	0	0.008361	0	32	46									
OR5M3	219482	broad.mit.edu	37	11	56237065	56237065	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:56237065G>A	uc010rjk.1	-	1	909	c.909C>T	c.(907-909)ATC>ATT	p.I303I		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	303	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATGATCTGCTGATCACTTTCA	0.343		NaN											0	0	0	0.00333	0	18	25									
OR5M3	219482	broad.mit.edu	37	11	56237767	56237767	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:56237767C>T	uc010rjk.1	-	1	207	c.207G>A	c.(205-207)GTG>GTA	p.V69V		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AAGAAAACCACACATCAACAA	0.388		NaN											0	0	0	0.01441	0	54	87									
RTN4RL2	349667	broad.mit.edu	37	11	57243799	57243799	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:57243799C>T	uc010rjt.1	+	3	678	c.678C>T	c.(676-678)CTC>CTT	p.L226L		NM_178570	NP_848665	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2 precursor	226					axon regeneration	anchored to plasma membrane	receptor activity				0						TCCGCGGCCTCAGCCGCCTCA	0.706		NaN											0	0	0	0.001855	0	6	8									
DTX4	23220	broad.mit.edu	37	11	58940200	58940200	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:58940200G>A	uc001nns.2	+	1	389	c.132G>A	c.(130-132)GTG>GTA	p.V44V	DTX4_uc001nnr.2_Intron	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	44	WWE 1.				Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				ggggcAGCGTGGTGCTGGGCC	0.582		NaN											0	0	0	0.000602	0	5	1									
MS4A2	2206	broad.mit.edu	37	11	59856269	59856269	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:59856269C>T	uc001nop.2	+	1	133	c.31C>T	c.(31-33)CTT>TTT	p.L11F	MS4A2_uc009ymu.2_Missense_Mutation_p.L11F	NM_000139	NP_000130	Q01362	FCERB_HUMAN	membrane-spanning 4-domains, subfamily A, member	11	Cytoplasmic (Potential).				cell proliferation|humoral immune response	integral to plasma membrane	calcium channel activity			ovary(1)	1		all_epithelial(135;0.245)			Omalizumab(DB00043)	GAGAGCAAATCTTGCTCTCCC	0.413		NaN											0	0	0	0.010729	0	11	21									
MS4A14	84689	broad.mit.edu	37	11	60164085	60164085	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:60164085C>T	uc001npj.2	+	1	599	c.34C>T	c.(34-36)CAC>TAC	p.H12Y	MS4A14_uc001npi.2_Intron|MS4A14_uc001npn.2_5'UTR|MS4A14_uc001npk.2_Missense_Mutation_p.H12Y|MS4A14_uc001npl.2_5'UTR|MS4A14_uc001npm.2_5'UTR	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	12						integral to membrane	receptor activity			breast(1)	1						AAGGGCAACTCACGTCATCAC	0.453		NaN											0	0	0	0.013537	0	12	27									
CD6	923	broad.mit.edu	37	11	60781007	60781007	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:60781007C>T	uc001nqq.2	+	7	1486	c.1263C>T	c.(1261-1263)TTC>TTT	p.F421F	CD6_uc009yni.2_Silent_p.F320F|CD6_uc009ynj.2_Silent_p.F298F|CD6_uc001nqp.2_Silent_p.F421F|CD6_uc001nqr.2_Silent_p.F421F|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Silent_p.F421F	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	421	Helical; (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						TCATAGCCTTCATCCTCTTGA	0.507		NaN											0	0	0	0.01441	0	60	176									
DDB1	1642	broad.mit.edu	37	11	61067688	61067688	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:61067688C>T	uc001nrc.3	-	27	3569	c.3343G>A	c.(3343-3345)GAC>AAC	p.D1115N		NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	1115	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						CTGCCATCGTCATACTGCAAT	0.592		NaN						NER					0	0	0	0.001168	0	5	13									
AHNAK	79026	broad.mit.edu	37	11	62297473	62297473	+	Silent	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62297473T>C	uc001ntl.2	-	5	4716	c.4416A>G	c.(4414-4416)ACA>ACG	p.T1472T	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1472					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTTTGGAACTGTTACATCAT	0.398		NaN											0	0	0	0.01441	0	186	191									
EML3	256364	broad.mit.edu	37	11	62372641	62372641	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62372641G>C	uc001ntu.1	-	16	2234	c.1926C>G	c.(1924-1926)CTC>CTG	p.L642L	EML3_uc001ntr.1_Silent_p.L614L|EML3_uc001nts.1_Silent_p.L614L|EML3_uc001ntt.1_Silent_p.L526L|EML3_uc010rly.1_Silent_p.L642L	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	642						cytoplasm|microtubule	protein binding			ovary(1)	1						AGTCAGCACAGAGACCAGTCT	0.562		NaN											0	0	0	0.004007	0	16	57									
GANAB	23193	broad.mit.edu	37	11	62400737	62400737	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62400737C>T	uc001nub.2	-	7	670	c.637G>A	c.(637-639)GAG>AAG	p.E213K	GANAB_uc001nua.2_Missense_Mutation_p.E235K|GANAB_uc001nuc.2_Missense_Mutation_p.E116K|GANAB_uc010rma.1_Missense_Mutation_p.E121K|GANAB_uc010rmb.1_Missense_Mutation_p.E99K	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	213					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CCCTGAGTCTCCTCTGGCTGT	0.522		NaN											0	0	0	0.001984	0	7	157									
GANAB	23193	broad.mit.edu	37	11	62406471	62406471	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62406471C>T	uc001nub.2	-	4	397	c.364G>A	c.(364-366)GAT>AAT	p.D122N	GANAB_uc001nua.2_Missense_Mutation_p.D122N|GANAB_uc001nuc.2_Missense_Mutation_p.D25N|GANAB_uc010rma.1_Intron|GANAB_uc010rmb.1_Intron	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	122					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						ATTGGTGGATCAGCCACCAAA	0.483		NaN											0	0	0	0.007413	0	20	28									
TTC9C	283237	broad.mit.edu	37	11	62505817	62505817	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62505817G>C	uc001nuy.2	+	3	848	c.479G>C	c.(478-480)AGA>ACA	p.R160T	TTC9C_uc001nux.2_Missense_Mutation_p.R293T	NM_173810	NP_776171	Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	160							binding			ovary(1)|pancreas(1)	2						AGCTACCATAGAAAAGAGAAG	0.458		NaN											0	0	0	0.004672	0	3	18									
ZBTB3	79842	broad.mit.edu	37	11	62519909	62519909	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62519909C>A	uc001nuz.2	-	2	1500	c.1378G>T	c.(1378-1380)GCT>TCT	p.A460S		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						CTTCCTGGAGCTGCTTCGTAC	0.552		NaN											1	0	7.11191e-15	0.013726	7.46269e-15	34	60									
NXF1	10482	broad.mit.edu	37	11	62563940	62563940	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62563940G>C	uc001nvf.1	-	14	1414	c.1278C>G	c.(1276-1278)AAC>AAG	p.N426K	NXF1_uc001nvg.1_3'UTR|NXF1_uc009yog.1_Missense_Mutation_p.N469K	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	426	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						ACCGGGCAGGGTTCTGAGGAA	0.562		NaN											0	0	0	0.008291	0	10	111									
SLC22A8	9376	broad.mit.edu	37	11	62767306	62767306	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:62767306C>T	uc001nwo.2	-	4	582	c.446G>A	c.(445-447)CGC>CAC	p.R149H	SLC22A8_uc001nwn.1_5'Flank|SLC22A8_uc001nwp.2_Missense_Mutation_p.R149H|SLC22A8_uc009yom.2_Missense_Mutation_p.R26H|SLC22A8_uc010rmm.1_Missense_Mutation_p.R58H|SLC22A8_uc009yon.2_Missense_Mutation_p.R149H	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	149	Cytoplasmic (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						GATGGGCCTGCGGCCAAACCT	0.627		NaN											0	0	0	0.000602	0	4	22									
MARK2	2011	broad.mit.edu	37	11	63668428	63668428	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:63668428G>A	uc001nxw.2	+	11	1568	c.989_splice	c.e11-1	p.E330_splice	MARK2_uc001nxx.2_Splice_Site_p.E330_splice|MARK2_uc001nxy.2_Splice_Site_p.E330_splice|MARK2_uc001nxv.3_Splice_Site_p.E330_splice|MARK2_uc001nxz.3_Splice_Site_p.E297_splice|MARK2_uc009yoy.2_Splice_Site_p.E297_splice	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2						cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CCCCTGTGCAGAGCTGATGGT	0.577		NaN											0	0	0	0.01441	0	49	57									
GPR137	56834	broad.mit.edu	37	11	64054074	64054074	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64054074G>A	uc001nzg.1	+	2	386	c.78G>A	c.(76-78)CTG>CTA	p.L26L	BAD_uc001nzd.2_5'Flank|BAD_uc001nzc.2_5'Flank|GPR137_uc009ypj.1_Silent_p.L32L|BAD_uc009ypk.2_5'Flank|GPR137_uc010rni.1_Silent_p.L84L|GPR137_uc001nze.1_Silent_p.L26L|GPR137_uc001nzf.2_Silent_p.L26L|GPR137_uc001nzh.1_Silent_p.L26L|GPR137_uc001nzi.2_Silent_p.L26L|GPR137_uc010rnj.1_Silent_p.L26L	NM_020155	NP_064540	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	26	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CCCTGGGGCTGACAGCTGCCT	0.617		NaN											0	0	0	0.009535	0	29	87									
KCNK4	50801	broad.mit.edu	37	11	64067112	64067112	+	Silent	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64067112A>C	uc001nzj.1	+	7	1419	c.1096A>C	c.(1096-1098)AGA>CGA	p.R366R	KCNK4_uc001nzk.1_Missense_Mutation_p.E250A|KCNK4_uc010rnk.1_Silent_p.R194R|KCNK4_uc001nzl.1_Missense_Mutation_p.E250A|KCNK4_uc001nzm.3_RNA|KCNK4_uc001nzn.1_Silent_p.R366R|KCNK4_uc001nzo.2_Silent_p.R366R|KCNK4_uc001nzp.1_Silent_p.R252R|C11orf20_uc009ypm.2_5'Flank	NM_033310	NP_201567	Q9NYG8	KCNK4_HUMAN	TRAAK	366	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						CCGCGCGCCGAGAGGTCGCCG	0.627		NaN											0	0	0	0.000602	0	4	19									
TRMT112	51504	broad.mit.edu	37	11	64084577	64084577	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64084577C>T	uc001nzt.2	-	3	258	c.223G>A	c.(223-225)GAG>AAG	p.E75K	PRDX5_uc001nzu.2_5'Flank|PRDX5_uc001nzv.2_5'Flank|PRDX5_uc001nzw.2_5'Flank|PRDX5_uc001nzx.2_5'Flank	NM_016404	NP_057488	Q9UI30	TR112_HUMAN	tRNA methyltransferase 11-2 homolog	75	TRM112.				peptidyl-glutamine methylation	protein complex	protein binding|protein methyltransferase activity				0						TCATTCTCCTCATATCCCTCA	0.617		NaN											0	0	0	0.009535	0	27	29									
RPS6KA4	8986	broad.mit.edu	37	11	64138842	64138842	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64138842A>T	uc001oae.2	+	17	2292	c.2209A>T	c.(2209-2211)AGC>TGC	p.S737C	RPS6KA4_uc001oad.2_Missense_Mutation_p.S731C|RPS6KA4_uc010rnl.1_Missense_Mutation_p.S674C|RPS6KA4_uc001oaf.2_Missense_Mutation_p.S730C|RPS6KA4_uc009ypp.2_Missense_Mutation_p.S489C	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	737					axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						GAAGCTGCGGAGCGCCACCGC	0.721		NaN											0	0	0	0.001168	0	4	20									
SF1	7536	broad.mit.edu	37	11	64536954	64536954	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64536954G>A	uc001obb.1	-	6	984	c.607C>T	c.(607-609)CTT>TTT	p.L203F	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Missense_Mutation_p.L177F|SF1_uc001oaz.1_Missense_Mutation_p.L328F|SF1_uc001oba.1_Missense_Mutation_p.L203F|SF1_uc001obc.1_Missense_Mutation_p.L203F|SF1_uc001obd.1_Missense_Mutation_p.L203F|SF1_uc001obe.1_Missense_Mutation_p.L88F|SF1_uc010rno.1_Missense_Mutation_p.L88F	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	203	KH.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						AGGGCATGAAGTGGCTCATCT	0.522		NaN											0	0	0	0.01441	0	141	243									
MEN1	4221	broad.mit.edu	37	11	64571923	64571923	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64571923C>T	uc001obj.2	-	10	1804	c.1731G>A	c.(1729-1731)TCG>TCA	p.S577S	MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Silent_p.S577S|MEN1_uc001obl.2_Silent_p.S537S|MEN1_uc001obm.2_Silent_p.S572S|MEN1_uc001obn.2_Silent_p.S577S|MEN1_uc001obo.2_Silent_p.S577S|MEN1_uc001obp.2_Silent_p.S572S|MEN1_uc001obq.2_Silent_p.S577S|MEN1_uc001obr.2_Silent_p.S577S	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	577					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.S573_A574del(1)		parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						TGATGGCGCTCGAGTTGATCT	0.562		NaN	D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01441	0	148	159									
MEN1	4221	broad.mit.edu	37	11	64577195	64577195	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:64577195G>A	uc001obj.2	-	2	460	c.387C>T	c.(385-387)CTC>CTT	p.L129L	MEN1_uc001obk.2_Silent_p.L129L|MEN1_uc001obl.2_Silent_p.L129L|MEN1_uc001obm.2_Silent_p.L129L|MEN1_uc001obn.2_Silent_p.L129L|MEN1_uc001obo.2_Silent_p.L129L|MEN1_uc001obp.2_Silent_p.L129L|MEN1_uc001obq.2_Silent_p.L129L|MEN1_uc001obr.2_Silent_p.L129L	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	129					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.I125fs*53(1)		parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						AGGAGCGGCTGAGGCTGTTCC	0.572		NaN	D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01441	0	62	119									
SLC25A45	283130	broad.mit.edu	37	11	65147003	65147003	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:65147003G>A	uc001odp.1	-	4	605	c.183C>T	c.(181-183)TTC>TTT	p.F61F	SLC25A45_uc009yqi.1_Intron|SLC25A45_uc001odq.1_Silent_p.F37F|SLC25A45_uc001odr.1_Silent_p.F61F|SLC25A45_uc001ods.1_Silent_p.F19F|SLC25A45_uc001odt.1_Silent_p.F19F	NM_001077241	NP_001070709	Q8N413	S2545_HUMAN	solute carrier family 25, member 45 isoform b	61	Solcar 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						TGGCAATGGGGAAGCTCATTC	0.622		NaN											0	0	0	0.004007	0	17	41									
FRMD8	83786	broad.mit.edu	37	11	65161130	65161130	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:65161130G>A	uc001odu.3	+	4	532	c.340G>A	c.(340-342)GAT>AAT	p.D114N	FRMD8_uc009yqj.2_Missense_Mutation_p.D58N|FRMD8_uc010rof.1_Intron	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	114	FERM.					cytoskeleton	binding			lung(1)|pancreas(1)	2						TGCCCCAGACGATGACGTGGC	0.652		NaN											0	0	0	0.000602	0	5	13									
PCNXL3	399909	broad.mit.edu	37	11	65401671	65401671	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:65401671G>A	uc001oey.2	+	28	4545	c.4545G>A	c.(4543-4545)CTG>CTA	p.L1515L	PCNXL3_uc001oez.2_Silent_p.L402L	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1515						integral to membrane					0						CGGCAGCCCTGAGGCCTGTGC	0.642		NaN											0	0	0	0.001168	0	5	20									
GAL3ST3	89792	broad.mit.edu	37	11	65812872	65812872	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:65812872G>A	uc001ogv.2	-	1	175	c.15C>T	c.(13-15)CTC>CTT	p.L5L	GAL3ST3_uc001ogw.2_Silent_p.L5L	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	5	Cytoplasmic (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						GCAGGCGCTGGAGGATGGGTG	0.647		NaN									OREG0021093	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	36									
RIN1	9610	broad.mit.edu	37	11	66099752	66099752	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:66099752C>G	uc001ohn.1	-	10	2474	c.2347G>C	c.(2347-2349)GAG>CAG	p.E783Q	RIN1_uc010roy.1_Missense_Mutation_p.E414Q|RIN1_uc009yrd.1_Missense_Mutation_p.E476Q|RIN1_uc010roz.1_Missense_Mutation_p.E678Q|RIN1_uc010rpa.1_Missense_Mutation_p.E617Q	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	783					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						TCAAGCTACTCCTCTGCTGCC	0.632		NaN											0	0	0	0.01441	0	53	122									
RIN1	9610	broad.mit.edu	37	11	66099842	66099842	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:66099842C>G	uc001ohn.1	-	10	2384	c.2257G>C	c.(2257-2259)GAG>CAG	p.E753Q	RIN1_uc010roy.1_Missense_Mutation_p.E384Q|RIN1_uc009yrd.1_Missense_Mutation_p.E446Q|RIN1_uc010roz.1_Missense_Mutation_p.E648Q|RIN1_uc010rpa.1_Missense_Mutation_p.E587Q	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	753					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						GCAGTTGTCTCAGACTGTTCC	0.632		NaN											0	0	0	0.01441	0	60	159									
NPAS4	266743	broad.mit.edu	37	11	66192561	66192561	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:66192561G>A	uc001ohx.1	+	7	2376	c.2200G>A	c.(2200-2202)GAG>AAG	p.E734K	NPAS4_uc010rpc.1_Missense_Mutation_p.E524K	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	734					transcription, DNA-dependent		DNA binding|signal transducer activity				0						TCCTGAGGCAGAGGGCCCAGG	0.577		NaN											0	0	0	0.007291	0	30	139									
BBS1	582	broad.mit.edu	37	11	66291352	66291352	+	Missense_Mutation	SNP	C	C	G	rs141255069	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:66291352C>G	uc001oij.1	+	11	1121	c.1109C>G	c.(1108-1110)CCG>CGG	p.P370R	BBS1_uc001oii.1_Missense_Mutation_p.P407R|BBS1_uc010rpg.1_Missense_Mutation_p.P273R|BBS1_uc001oik.1_Missense_Mutation_p.P294R|BBS1_uc001oil.1_Intron|ZDHHC24_uc001oim.1_Intron|ZDHHC24_uc009yrg.1_Intron|BBS1_uc010rph.1_Missense_Mutation_p.P38R	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	370					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						ATCCACACCCCGGTGAGCCCC	0.587		NaN							Bardet-Biedl_syndrome				0	0	0	0.001984	0	6	57									
ADRBK1	156	broad.mit.edu	37	11	67051768	67051768	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:67051768C>T	uc009yrn.1	+	18	1844	c.1578C>T	c.(1576-1578)TTC>TTT	p.F526F	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	526					activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	AGACTGTCTTCGACACCATCA	0.602		NaN											0	0	0	0.00245	0	13	81									
SAPS3	55291	broad.mit.edu	37	11	68363635	68363635	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:68363635G>A	uc001onw.2	+	19	2254	c.1987G>A	c.(1987-1989)GAA>AAA	p.E663K	SAPS3_uc001onv.2_Missense_Mutation_p.E663K|SAPS3_uc001ony.3_Missense_Mutation_p.E634K|SAPS3_uc001onx.2_Missense_Mutation_p.E657K|SAPS3_uc009ysh.2_Missense_Mutation_p.E583K|SAPS3_uc001onu.2_Missense_Mutation_p.E583K|SAPS3_uc010rqc.1_Missense_Mutation_p.E431K|SAPS3_uc010rqd.1_Missense_Mutation_p.E346K|SAPS3_uc001onz.2_5'UTR|SAPS3_uc001ooa.2_Missense_Mutation_p.E113K	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	663					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			AGACTTGTTTGAACCCAGCAG	0.453		NaN											0	0	0	0.01441	0	51	50									
CPT1A	1374	broad.mit.edu	37	11	68527743	68527743	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:68527743C>G	uc001oog.3	-	17	2262	c.2092G>C	c.(2092-2094)GAC>CAC	p.D698H	CPT1A_uc001oof.3_Missense_Mutation_p.D698H|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	698	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	TTCTCCAAGTCAAACAGCTCC	0.557		NaN											0	0	0	0.003163	0	16	16									
MRGPRD	116512	broad.mit.edu	37	11	68747724	68747724	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:68747724G>A	uc010rqf.1	-	1	732	c.732C>T	c.(730-732)CTC>CTT	p.L244L		NM_198923	NP_944605	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	244	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(1)	1			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TCAACCAGTAGAGCACAAACC	0.612		NaN											0	0	0	0.008361	0	32	40									
CCND1	595	broad.mit.edu	37	11	69458749	69458749	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:69458749C>T	uc001opa.2	+	3	773	c.564C>T	c.(562-564)CTC>CTT	p.L188L		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	188				L -> S (in Ref. 3; AAA52136).	cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	TCGTTGCCCTCTGTGCCACAG	0.617		NaN	T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			0	0	0	0.00245	0	14	12									
C2CD3	26005	broad.mit.edu	37	11	73796738	73796738	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:73796738C>T	uc001ouu.2	-	21	4062	c.3835G>A	c.(3835-3837)GAG>AAG	p.E1279K	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1279	C2 1.					centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					AAACAGGCCTCTCCACTACAG	0.473		NaN											0	0	0	0.003163	0	16	34									
OR2AT4	341152	broad.mit.edu	37	11	74800029	74800029	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:74800029A>G	uc010rro.1	-	1	730	c.730T>C	c.(730-732)TCC>CCC	p.S244P		NM_001005285	NP_001005285	A6NND4	O2AT4_HUMAN	olfactory receptor, family 2, subfamily AT,	244	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGCAGGTGGAGAAGGCTTTT	0.567		NaN											0	0	0	0.004007	0	14	20									
C11orf30	56946	broad.mit.edu	37	11	76255317	76255317	+	Silent	SNP	C	C	T	rs146751469		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:76255317C>T	uc001oxl.2	+	19	2867	c.2724C>T	c.(2722-2724)CAC>CAT	p.H908H	C11orf30_uc001oxm.2_Silent_p.H810H|C11orf30_uc010rsb.1_Silent_p.H923H|C11orf30_uc010rsc.1_Silent_p.H909H|C11orf30_uc001oxn.2_Silent_p.H909H|C11orf30_uc010rsd.1_Silent_p.H817H|C11orf30_uc001oxo.1_Silent_p.H262H|C11orf30_uc010rse.1_Silent_p.H155H|C11orf30_uc001oxp.2_Silent_p.H8H	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	908					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						TAAGCAGTCACACTGCTTTTA	0.403		NaN											0	0	0	0.00499	0	17	41									
AQP11	282679	broad.mit.edu	37	11	77301461	77301461	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:77301461G>A	uc001oyj.2	+	1	782	c.424G>A	c.(424-426)GGT>AGT	p.G142S	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	142						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GTGGAGCTTGGGTCTGACCCA	0.602		NaN											0	0	0	0.008871	0	20	29									
AQP11	282679	broad.mit.edu	37	11	77301511	77301511	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:77301511C>T	uc001oyj.2	+	1	832	c.474C>T	c.(472-474)CCC>CCT	p.P158P	AQP11_uc009yuu.2_Intron	NM_173039	NP_766627	Q8NBQ7	AQP11_HUMAN	aquaporin 11	158						cell surface|integral to membrane	transporter activity				0	all_cancers(14;1.75e-17)|all_epithelial(13;4.7e-20)|Ovarian(111;0.249)		Epithelial(5;4.73e-49)|BRCA - Breast invasive adenocarcinoma(5;1.4e-30)			GCAAGAATCCCATCCGAGTCG	0.567		NaN											0	0	0	0.004656	0	28	49									
ODZ4	26011	broad.mit.edu	37	11	78399156	78399156	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:78399156C>T	uc001ozl.3	-	29	5666	c.5203G>A	c.(5203-5205)GAT>AAT	p.D1735N	ODZ4_uc009yvb.1_Missense_Mutation_p.D319N	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1735	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						ATGGTGACATCATCCTTGCTG	0.562		NaN											0	0	0	0.00333	0	25	78									
C11orf82	220042	broad.mit.edu	37	11	82625788	82625788	+	Missense_Mutation	SNP	G	G	A	rs142883872	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:82625788G>A	uc001ozt.2	+	3	252	c.8G>A	c.(7-9)AGA>AAA	p.R3K	C11orf82_uc010rsr.1_5'UTR|C11orf82_uc010rss.1_5'UTR|C11orf82_uc009yvd.2_Missense_Mutation_p.R3K	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	3					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						CACATGAACAGAAGACGAAAA	0.398		NaN											0	0	0	0.010729	0	10	52									
PCF11	51585	broad.mit.edu	37	11	82877677	82877677	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:82877677G>A	uc001ozx.3	+	5	2083	c.1738G>A	c.(1738-1740)GAA>AAA	p.E580K	PCF11_uc010rsu.1_Missense_Mutation_p.E580K	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	580					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GTCAGGCACTGAACCAAAGGA	0.388		NaN											0	0	0	0.006122	0	18	88									
PCF11	51585	broad.mit.edu	37	11	82877695	82877695	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:82877695G>A	uc001ozx.3	+	5	2101	c.1756G>A	c.(1756-1758)GAA>AAA	p.E586K	PCF11_uc010rsu.1_Missense_Mutation_p.E586K	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	586					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						GGAGAATGTAGAAAACTGGCA	0.393		NaN											0	0	0	0.01441	0	62	45									
CCDC89	220388	broad.mit.edu	37	11	85396454	85396454	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:85396454G>A	uc001pau.1	-	1	867	c.720C>T	c.(718-720)CAC>CAT	p.H240H		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	240	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CAGCCTGCTGGTGCTGCTGCT	0.617		NaN											0	0	0	0.014323	0	19	107									
C11orf73	51501	broad.mit.edu	37	11	86048553	86048553	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:86048553C>T	uc001pbu.2	+	3	639	c.401C>T	c.(400-402)TCA>TTA	p.S134L	C11orf73_uc001pbt.2_Missense_Mutation_p.S134L|C11orf73_uc010rto.1_RNA|C11orf73_uc010rtp.1_Missense_Mutation_p.S35L|C11orf73_uc001pbv.2_RNA	NM_016401	NP_057485	Q53FT3	CK073_HUMAN	lethal, Chr 7, Rinchik 6	134						cytoplasm					0		Acute lymphoblastic leukemia(157;1.17e-07)|all_hematologic(158;0.000556)				GCTGTATCCTCAGTTGACTCA	0.338		NaN											0	0	0	0.01441	0	48	319									
HEPHL1	341208	broad.mit.edu	37	11	93796691	93796692	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:93796691_93796692GG>AA	uc001pep.2	+	3	590_591	c.433_434GG>AA	c.(433-435)GGA>AAA	p.G145K		NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	145	Plastocyanin-like 1.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATACCCAGATGGAACATCTGGA	0.322		NaN											0	0	0	0.004672	0	6	7									
HEPHL1	341208	broad.mit.edu	37	11	93808405	93808405	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:93808405G>A	uc001pep.2	+	9	1727	c.1570G>A	c.(1570-1572)GAG>AAG	p.E524K	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	524	Plastocyanin-like 3.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				GACAGTGCCTGAGAGCGTAAG	0.468		NaN											0	0	0	0.013537	0	12	21									
GPR83	10888	broad.mit.edu	37	11	94113882	94113882	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:94113882G>A	uc001pet.2	-	4	877	c.705C>T	c.(703-705)TTC>TTT	p.F235F		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	235	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GGTACTTCCAGAAGAGGTCAG	0.587		NaN											0	0	0	0.000602	0	5	20									
GPR83	10888	broad.mit.edu	37	11	94113903	94113903	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:94113903G>T	uc001pet.2	-	4	856	c.684C>A	c.(682-684)TTC>TTA	p.F228L		NM_016540	NP_057624	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83 precursor	228	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			central_nervous_system(2)|ovary(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CTGGCTCAGGGAAGTCTGGCA	0.572		NaN											1	0	5.9392e-07	0.001168	6.10519e-07	5	24									
MMP12	4321	broad.mit.edu	37	11	102736603	102736603	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:102736603G>T	uc001phk.2	-	9	1154	c.1109C>A	c.(1108-1110)TCT>TAT	p.S370Y		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	370	Hemopexin-like 2.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AAAACCAAAAGAATGTATGCT	0.328		NaN											1	0	4.36969e-10	0.001855	4.54565e-10	13	24									
CASP1	834	broad.mit.edu	37	11	104899926	104899926	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:104899926C>A	uc010rve.1	-	7	948	c.931G>T	c.(931-933)GAA>TAA	p.E311*	CASP1_uc001pig.2_Nonsense_Mutation_p.E218*|CASP1_uc001pik.2_Nonsense_Mutation_p.E274*|CASP1_uc010rvf.1_Nonsense_Mutation_p.E218*|CASP1_uc010rvg.1_Nonsense_Mutation_p.E290*|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron|CASP1_uc001pim.3_Nonsense_Mutation_p.E311*|CASP1_uc009yxi.2_Nonsense_Mutation_p.E290*|CASP1_uc010rvj.1_Nonsense_Mutation_p.E311*|CASP1_uc009yxj.2_Nonsense_Mutation_p.E156*|CASP1_uc010rvk.1_Nonsense_Mutation_p.E272*	NM_033292	NP_150634	P29466	CASP1_HUMAN	caspase 1 isoform alpha precursor	311					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			ovary(2)	2		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TCAAACTCTTCTGTAGTTGGT	0.413		NaN											1	0	9.16793e-09	0.00499	9.49614e-09	16	40									
GUCY1A2	2977	broad.mit.edu	37	11	106680837	106680837	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:106680837G>A	uc001pjg.1	-	5	1964	c.1574C>T	c.(1573-1575)TCA>TTA	p.S525L	GUCY1A2_uc010rvo.1_Missense_Mutation_p.S546L|GUCY1A2_uc009yxn.1_Missense_Mutation_p.S525L	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	525	Guanylate cyclase.				intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AACAATGTCTGAAAAGAGCAT	0.453		NaN											0	0	0	0.006122	0	18	41									
RAB39	54734	broad.mit.edu	37	11	107799300	107799300	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:107799300G>C	uc001pjt.2	+	1	24	c.6G>C	c.(4-6)GAG>GAC	p.E2D		NM_017516	NP_059986	Q14964	RB39A_HUMAN	RAB39, member RAS oncogene family	2					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0				BRCA - Breast invasive adenocarcinoma(274;3.04e-05)|Epithelial(105;8.56e-05)|all cancers(92;0.00179)		GAGCGATGGAGACCATCTGGA	0.632		NaN											0	0	0	0.009096	0	4	5									
CUL5	8065	broad.mit.edu	37	11	107968457	107968457	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:107968457C>T	uc001pjv.2	+	17	2667	c.2000C>T	c.(1999-2001)TCA>TTA	p.S667L	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	667					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		ACCCTCTTCTCAGTGAACCAG	0.348		NaN											0	0	0	0.00333	0	23	47									
PPP2R1B	5519	broad.mit.edu	37	11	111614220	111614220	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:111614220G>A	uc001plx.1	-	12	1518	c.1434C>T	c.(1432-1434)CTC>CTT	p.L478L	PPP2R1B_uc001plw.1_Silent_p.L478L|PPP2R1B_uc010rwi.1_Silent_p.L414L|PPP2R1B_uc010rwj.1_Silent_p.L317L|PPP2R1B_uc010rwk.1_Silent_p.L433L|PPP2R1B_uc010rwl.1_Silent_p.L351L	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	478	HEAT 12.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		CTAGTTTCATGAGGTTGTTGG	0.383		NaN											0	0	0	0.01441	0	49	83									
C11orf1	64776	broad.mit.edu	37	11	111753253	111753253	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:111753253G>T	uc001pmd.2	+	2	544	c.207G>T	c.(205-207)CTG>CTT	p.L69L	C11orf1_uc001pme.2_Silent_p.L109L	NM_022761	NP_073598	Q9H5F2	CK001_HUMAN	hypothetical protein LOC64776	69						nucleus					0		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		ACCGTACCCTGATGGGCAACT	0.438		NaN											1	0	4.3838e-07	0.001855	4.5106e-07	13	16									
CLDN25	644672	broad.mit.edu	37	11	113651192	113651192	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:113651192G>A	uc009yyw.1	+	1	675	c.675G>A	c.(673-675)AGG>AGA	p.R225R		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	225	Cytoplasmic (Potential).					integral to membrane|tight junction	structural molecule activity				0						TAAGACCTAGGAACCTGGTCA	0.498		NaN											0	0	0	0.010504	0	21	50									
MLL	4297	broad.mit.edu	37	11	118348840	118348840	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:118348840G>A	uc001pta.2	+	5	3516	c.3493G>A	c.(3493-3495)GAG>AAG	p.E1165K	MLL_uc001ptb.2_Missense_Mutation_p.E1165K	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1165	CXXC-type.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CCAGGTGCCTGAGGACTGTGG	0.498		NaN	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.01441	0	50	96									
BCL9L	283149	broad.mit.edu	37	11	118773239	118773239	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:118773239C>T	uc001pug.2	-	6	2178	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	BCL9L_uc009zal.2_Missense_Mutation_p.E400K	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	405	Pro-rich.|Necessary for interaction with CTNNB1 (By similarity).				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		TCCCGATGCTCCAGCTGCTCT	0.687		NaN											0	0	0	0.00308	0	6	19									
NLRX1	79671	broad.mit.edu	37	11	119044232	119044232	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:119044232C>G	uc001pvu.2	+	5	489	c.274C>G	c.(274-276)CGG>GGG	p.R92G	NLRX1_uc010rzc.1_5'UTR|NLRX1_uc001pvv.2_Missense_Mutation_p.R92G|NLRX1_uc001pvw.2_Missense_Mutation_p.R92G|NLRX1_uc001pvx.2_Missense_Mutation_p.R92G	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	92	Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GTGGTTCAGCCGGCTGCCCAG	0.587		NaN											0	0	0	0.004007	0	16	38									
NLRX1	79671	broad.mit.edu	37	11	119044292	119044292	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:119044292G>A	uc001pvu.2	+	5	549	c.334G>A	c.(334-336)GAC>AAC	p.D112N	NLRX1_uc010rzc.1_5'UTR|NLRX1_uc001pvv.2_Missense_Mutation_p.D112N|NLRX1_uc001pvw.2_Missense_Mutation_p.D112N|NLRX1_uc001pvx.2_Missense_Mutation_p.D112N	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	112	Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GGTCCACGTTGACCCTGTGAT	0.672		NaN											0	0	0	0.012319	0	22	30									
NLRX1	79671	broad.mit.edu	37	11	119050897	119050897	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:119050897G>A	uc001pvu.2	+	7	2382	c.2167G>A	c.(2167-2169)GGA>AGA	p.G723R	NLRX1_uc010rzc.1_Missense_Mutation_p.G545R|NLRX1_uc001pvv.2_Missense_Mutation_p.G723R|NLRX1_uc001pvw.2_Missense_Mutation_p.G723R|NLRX1_uc001pvx.2_Missense_Mutation_p.G723R	NM_024618	NP_078894	Q86UT6	NLRX1_HUMAN	NLR family member X1 isoform 1	723	Required for the repression of MAVS- induced interferon signaling.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			ovary(1)|skin(1)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCTGGGCAGCGGAAGGCATGC	0.637		NaN											0	0	0	0.00245	0	13	24									
MCAM	4162	broad.mit.edu	37	11	119181552	119181552	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:119181552G>A	uc001pwf.2	-	14	1736	c.1707C>T	c.(1705-1707)ATC>ATT	p.I569I	MCAM_uc001pwg.1_RNA	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	569	Helical; (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		CCAGGACCAGGATGCACACAA	0.617		NaN											0	0	0	0.012319	0	20	45									
TECTA	7007	broad.mit.edu	37	11	120989420	120989420	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:120989420G>C	uc010rzo.1	+	6	1196	c.1196G>C	c.(1195-1197)AGA>ACA	p.R399T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	399	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGCTATGGAAGAGTCAAGGTG	0.507		NaN											0	0	0	0.008871	0	21	42									
SC5DL	6309	broad.mit.edu	37	11	121174160	121174160	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:121174160G>C	uc001pxu.2	+	2	224	c.76G>C	c.(76-78)GAC>CAC	p.D26H	SC5DL_uc001pxs.1_Missense_Mutation_p.D26H|SC5DL_uc001pxt.2_Missense_Mutation_p.D26H|SC5DL_uc001pxv.2_Missense_Mutation_p.D26H	NM_006918	NP_008849	O75845	SC5D_HUMAN	sterol-C5-desaturase	26					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	C-5 sterol desaturase activity|iron ion binding|lathosterol oxidase activity			ovary(1)	1		Breast(109;0.00328)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)	OV - Ovarian serous cystadenocarcinoma(1;0.0334)	BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		GCCAGAAGATGACATCTTCCG	0.383		NaN											0	0	0	0.010818	0	30	56									
SORL1	6653	broad.mit.edu	37	11	121460047	121460047	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:121460047G>A	uc001pxx.2	+	29	4106	c.4026G>A	c.(4024-4026)TGG>TGA	p.W1342*	SORL1_uc010rzp.1_Nonsense_Mutation_p.W188*|SORL1_uc010rzq.1_5'Flank	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1342	Extracellular (Potential).|LDL-receptor class A 7.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GTTTGATTTGGAAGTGCGACG	0.478		NaN											0	0	0	0.01441	0	53	113									
DCPS	28960	broad.mit.edu	37	11	126215464	126215464	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:126215464G>A	uc001qdp.2	+	6	1299	c.970G>A	c.(970-972)GAC>AAC	p.D324N	uc001qdq.1_Intron	NM_014026	NP_054745	Q96C86	DCPS_HUMAN	mRNA decapping enzyme	324					deadenylation-dependent decapping of nuclear-transcribed mRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	exoribonuclease activity|protein binding				0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00949)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.0604)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.08)		CCTCAGGGCTGACGACCCCCT	0.607		NaN											0	0	0	0.013726	0	30	81									
KCNJ1	3758	broad.mit.edu	37	11	128709337	128709337	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:128709337G>A	uc001qeo.1	-	2	910	c.859C>T	c.(859-861)CTC>TTC	p.L287F	KCNJ1_uc001qep.1_Missense_Mutation_p.L268F|KCNJ1_uc001qeq.1_Missense_Mutation_p.L268F|KCNJ1_uc001qer.1_Missense_Mutation_p.L268F|KCNJ1_uc001qes.1_Missense_Mutation_p.L268F	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	287	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	TCCTGCTGGAGAAGGGTCTCC	0.483		NaN											0	0	0	0.01441	0	53	49									
ARHGAP32	9743	broad.mit.edu	37	11	128936684	128936684	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:128936684C>T	uc009zcp.2	-	6	569	c.569G>A	c.(568-570)CGA>CAA	p.R190Q	ARHGAP32_uc009zcq.1_Missense_Mutation_p.R150Q|ARHGAP32_uc001qfb.2_5'UTR	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	190	PX; atypical.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GGAAAATCTTCGGTCATAAAT	0.368		NaN											0	0	0	0.007413	0	20	28									
ADAMTS8	11095	broad.mit.edu	37	11	130278816	130278816	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:130278816C>G	uc001qgg.3	-	7	2128	c.1770G>C	c.(1768-1770)CAG>CAC	p.Q590H	ADAMTS8_uc001qgf.2_Missense_Mutation_p.Q71H	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	590	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TCTCACACTGCTGCTCCCTGA	0.547		NaN											0	0	0	0.005443	0	27	85									
SNX19	399979	broad.mit.edu	37	11	130785628	130785628	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:130785628G>A	uc001qgk.3	-	1	755	c.207C>T	c.(205-207)CTC>CTT	p.L69L	SNX19_uc010sce.1_Intron|SNX19_uc010scf.1_Intron|SNX19_uc010scg.1_Intron|SNX19_uc001qgl.3_Silent_p.L69L|SNX19_uc009zcx.1_Intron	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	69					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		CCACTCCAGCGAGGCTGGAGC	0.602		NaN											0	0	0	0.004007	0	14	30									
JAM3	83700	broad.mit.edu	37	11	134014688	134014688	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:134014688G>A	uc001qhb.1	+	5	570	c.546G>A	c.(544-546)GTG>GTA	p.V182V	JAM3_uc009zcz.1_Silent_p.V131V	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	137	Extracellular (Potential).				angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		TCCCCACAGTGAAGCCAGTGA	0.537		NaN											0	0	0	0.008871	0	19	48									
GLB1L2	89944	broad.mit.edu	37	11	134214971	134214971	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr11:134214971C>A	uc001qhp.2	+	4	585	c.397C>A	c.(397-399)CTG>ATG	p.L133M	GLB1L2_uc009zdg.1_5'Flank	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	133					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		GTGGGTGATTCTGCGTCCAGG	0.637		NaN											1	0	0.00909568	0.009096	0.00921888	4	10									
B4GALNT3	283358	broad.mit.edu	37	12	662717	662717	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:662717A>G	uc001qii.1	+	14	1628	c.1628A>G	c.(1627-1629)CAG>CGG	p.Q543R	B4GALNT3_uc001qij.1_Missense_Mutation_p.Q446R|B4GALNT3_uc001qik.1_Missense_Mutation_p.Q92R	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	543	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			AACCTGCCTCAGATGAGGGGG	0.617		NaN											0	0	0	0.012319	0	23	13									
FOXM1	2305	broad.mit.edu	37	12	2968485	2968485	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:2968485C>T	uc001qlf.2	-	9	1876	c.1611G>A	c.(1609-1611)GAG>GAA	p.E537E	uc001qld.2_Intron|FOXM1_uc001qle.2_Silent_p.E575E|FOXM1_uc001qlg.2_Silent_p.E522E|FOXM1_uc009zea.2_Silent_p.E522E|FOXM1_uc009zeb.2_Silent_p.E521E	NM_021953	NP_068772	Q08050	FOXM1_HUMAN	forkhead box M1 isoform 2	537					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			TCTCCCTCCTCTCCCTGTGTT	0.577		NaN											0	0	0	0.012213	0	30	49									
ANO2	57101	broad.mit.edu	37	12	5936945	5936945	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:5936945G>C	uc001qnm.2	-	7	942	c.870C>G	c.(868-870)AAC>AAG	p.N290K		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	295	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CCATCGTGTTGTTGGCTCGGG	0.657		NaN											0	0	0	0.009096	0	3	4									
SCNN1A	6337	broad.mit.edu	37	12	6457910	6457910	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:6457910C>T	uc001qnx.2	-	12	1901	c.1612G>A	c.(1612-1614)GAG>AAG	p.E538K	SCNN1A_uc001qnv.2_Missense_Mutation_p.E238K|SCNN1A_uc001qnw.2_Missense_Mutation_p.E597K|SCNN1A_uc010sfb.1_Missense_Mutation_p.E561K	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	538	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	GAGGGAGACTCAGAATTGGTT	0.522		NaN											0	0	0	0.00278	0	25	42									
CD4	920	broad.mit.edu	37	12	6926360	6926360	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:6926360G>T	uc001qqv.1	+	7	1265	c.1020G>T	c.(1018-1020)CTG>CTT	p.L340L	CD4_uc010sfj.1_Silent_p.L67L|CD4_uc009zfc.1_Silent_p.L161L|CD4_uc010sfk.1_Silent_p.L67L|CD4_uc010sfl.1_Silent_p.L67L|CD4_uc010sfm.1_Silent_p.L67L	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	340	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				AGCTGATGCTGAGTTTGAAAC	0.567		NaN											1	0	1.12685e-05	0.004482	1.1518e-05	9	18									
PHB2	11331	broad.mit.edu	37	12	7078670	7078670	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:7078670C>A	uc001qsd.2	-	3	493	c.283G>T	c.(283-285)GGC>TGC	p.G95C	PHB2_uc010sft.1_Missense_Mutation_p.G95C|PHB2_uc010sfu.1_Missense_Mutation_p.G95C|EMG1_uc009zfo.2_5'Flank|EMG1_uc001qsh.3_5'Flank|EMG1_uc010sfv.1_5'Flank	NM_001144831	NP_001138303	Q99623	PHB2_HUMAN	prohibitin 2 isoform 1	95					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						CCTTTGGAGCCTGTAGGGGAG	0.507		NaN											1	0	1.9806e-07	0.014323	2.04176e-07	19	48									
A2ML1	144568	broad.mit.edu	37	12	8988871	8988871	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:8988871G>A	uc001quz.3	+	7	762	c.664G>A	c.(664-666)GAA>AAA	p.E222K		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	66						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GTTTAAGGTGGAAGTGGTGGA	0.448		NaN											0	0	0	0.010729	0	10	30									
CDKN1B	1027	broad.mit.edu	37	12	12871770	12871770	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:12871770C>T	uc001rat.2	+	2	959	c.487C>T	c.(487-489)CAA>TAA	p.Q163*		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	163	Nuclear localization signal (Potential).				autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		TTCTTCTACTCAAAACAAAAG	0.448		NaN							Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				0	0	0	0.01441	0	72	33									
SLCO1C1	53919	broad.mit.edu	37	12	20864431	20864431	+	Silent	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:20864431C>A	uc001rej.3	+	6	871	c.516C>A	c.(514-516)TCC>TCA	p.S172S	SLCO1C1_uc010sii.1_Silent_p.S172S|SLCO1C1_uc010sij.1_Silent_p.S172S|SLCO1C1_uc009zip.2_Silent_p.S6S|SLCO1C1_uc001rei.2_Silent_p.S172S|SLCO1C1_uc010sik.1_Silent_p.S54S	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	172	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					AATCAAAATCCAAAATAAGTA	0.343		NaN											1	0	2.32416e-17	0.014323	2.45064e-17	23	39									
BHLHE41	79365	broad.mit.edu	37	12	26277470	26277470	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:26277470C>T	uc001rhb.2	-	2	399	c.108G>A	c.(106-108)ATG>ATA	p.M36I		NM_030762	NP_110389	Q9C0J9	BHE41_HUMAN	basic helix-loop-helix domain containing, class	36					cell differentiation|cell proliferation|organ morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CGTCTCGTTTCATGCTCCTTT	0.478		NaN											0	0	0	0.003755	0	35	19									
ITPR2	3709	broad.mit.edu	37	12	26943129	26943129	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:26943129C>T	uc001rhg.2	-	2	541	c.124G>A	c.(124-126)GAG>AAG	p.E42K	ITPR2_uc001rhh.1_Intron|ITPR2_uc001rhi.1_Missense_Mutation_p.E42K	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	42	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCCCCGGCCTCTGGGTGCACC	0.408		NaN											0	0	0	0.00245	0	13	34									
DDX11	1663	broad.mit.edu	37	12	31240903	31240903	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:31240903G>A	uc001rjt.1	+	6	921	c.670G>A	c.(670-672)GAA>AAA	p.E224K	DDX11_uc010sjw.1_Missense_Mutation_p.E224K|DDX11_uc010sjx.1_RNA|DDX11_uc001rjr.1_Missense_Mutation_p.E224K|DDX11_uc001rjs.1_Missense_Mutation_p.E224K|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.E224K|DDX11_uc001rjw.1_Missense_Mutation_p.E198K|DDX11_uc001rjx.1_5'UTR|DDX11_uc009zjn.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	224	Glu-rich.|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					CCTGGAGGAAGAACACATAAC	0.532		NaN								Multiple Myeloma(12;0.14)			0	0	0	0.000602	0	5	11									
SYT10	341359	broad.mit.edu	37	12	33592424	33592424	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:33592424G>A	uc001rll.1	-	1	331	c.34C>T	c.(34-36)CTG>TTG	p.L12L	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	12	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTCTGGCACAGACTGTTCACT	0.552		NaN											0	0	0	0.01441	0	44	100									
ABCD2	225	broad.mit.edu	37	12	39947845	39947845	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:39947845C>T	uc001rmb.2	-	10	2518	c.2092G>A	c.(2092-2094)GAA>AAA	p.E698K		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	698	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						TGTTTTTCTTCACTCAATGTC	0.383		NaN											0	0	0	0.009535	0	32	15									
LRRK2	120892	broad.mit.edu	37	12	40749951	40749951	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:40749951G>A	uc001rmg.3	+	46	6926	c.6805G>A	c.(6805-6807)GAT>AAT	p.D2269N	LRRK2_uc009zjw.2_Missense_Mutation_p.D1107N|LRRK2_uc001rmi.2_Missense_Mutation_p.D1102N	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2269					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TGGAACCGCTGATGGCAAGTT	0.224		NaN											0	0	0	0.001984	0	7	14									
ANO6	196527	broad.mit.edu	37	12	45781986	45781986	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:45781986T>C	uc001roo.2	+	11	1543	c.1208T>C	c.(1207-1209)CTT>CCT	p.L403P	ANO6_uc010sld.1_Missense_Mutation_p.L403P|ANO6_uc010sle.1_Missense_Mutation_p.L403P|ANO6_uc010slf.1_Missense_Mutation_p.L424P|ANO6_uc010slg.1_Missense_Mutation_p.L385P	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	403	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						CAGGCAGAACTTGAGTATGAA	0.423		NaN											0	0	0	0.01441	0	76	135									
SLC38A1	81539	broad.mit.edu	37	12	46582754	46582754	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:46582754C>T	uc001rpa.2	-	17	1721	c.1463G>A	c.(1462-1464)TGA>TAA	p.*488*	SLC38A1_uc001rpb.2_Silent_p.*488*|SLC38A1_uc001rpc.2_Silent_p.*488*|SLC38A1_uc001rpd.2_Silent_p.*488*|SLC38A1_uc001rpe.2_Silent_p.*488*	NM_030674	NP_109599	Q9H2H9	S38A1_HUMAN	amino acid transporter system A1	488					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			ovary(2)|skin(2)|central_nervous_system(1)	5	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			CGGCGGGTTTCAGTGGCCTTC	0.507		NaN											0	0	0	0.008871	0	17	65									
DDN	23109	broad.mit.edu	37	12	49391911	49391911	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:49391911G>A	uc001rsv.1	-	2	766	c.748C>T	c.(748-750)CAG>TAG	p.Q250*	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	250						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						GTGGGCACCTGAGAGTTCCCG	0.657		NaN											0	0	0	0.001855	0	14	69									
MLL2	8085	broad.mit.edu	37	12	49434778	49434778	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:49434778C>T	uc001rta.3	-	31	6775	c.6775G>A	c.(6775-6777)GAG>AAG	p.E2259K		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2259	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCAGGGCTCTCAGGCACAGCC	0.632		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.008871	0	16	34									
MLL2	8085	broad.mit.edu	37	12	49445264	49445264	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:49445264G>C	uc001rta.3	-	10	2202	c.2202C>G	c.(2200-2202)CTC>CTG	p.L734L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	734	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ACCGGGGGCAGAGTTGCGGCT	0.692		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.008291	0	4	23									
PRPH	5630	broad.mit.edu	37	12	49689233	49689233	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:49689233G>A	uc001rtu.2	+	1	325	c.250G>A	c.(250-252)GAG>AAG	p.E84K		NM_006262	NP_006253	P41219	PERI_HUMAN	peripherin	84	Head.						structural molecule activity				0						CTCCATGGCCGAGGCCCTCAA	0.682		NaN											0	0	0	0.001168	0	6	7									
PRPF40B	25766	broad.mit.edu	37	12	50036100	50036100	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:50036100G>A	uc001rur.1	+	19	1965	c.1901G>A	c.(1900-1902)CGA>CAA	p.R634Q	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001rup.1_Missense_Mutation_p.R656Q|PRPF40B_uc001ruq.1_Missense_Mutation_p.R621Q|PRPF40B_uc001rus.1_Missense_Mutation_p.R577Q|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	634					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						GCTGCCTTTCGAAGCATGCTG	0.642		NaN											0	0	0	0.01441	0	45	55									
PRPF40B	25766	broad.mit.edu	37	12	50037941	50037941	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:50037941G>A	uc001rur.1	+	25	2646	c.2582G>A	c.(2581-2583)CGG>CAG	p.R861Q	FMNL3_uc001ruv.1_3'UTR|FMNL3_uc001ruw.1_3'UTR|PRPF40B_uc001ruq.1_Missense_Mutation_p.R848Q|PRPF40B_uc001rus.1_Missense_Mutation_p.R803Q|FMNL3_uc001rut.1_3'UTR|FMNL3_uc001ruu.1_3'UTR	NM_001031698	NP_001026868	Q6NWY9	PR40B_HUMAN	Huntingtin interacting protein C isoform 1	861					mRNA processing|RNA splicing	nuclear speck				skin(2)|ovary(1)|pancreas(1)|kidney(1)	5						AGGCGGCGGCGGACACTCCTA	0.597		NaN									OREG0021798	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	4	29									
DIP2B	57609	broad.mit.edu	37	12	51130885	51130885	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:51130885C>G	uc001rwv.2	+	35	4324	c.4168C>G	c.(4168-4170)CTT>GTT	p.L1390V	DIP2B_uc009zlt.2_Missense_Mutation_p.L820V	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	1390						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						AGACTCTCACCTTGGAGAGGT	0.358		NaN											0	0	0	0.00623	0	37	143									
LETMD1	25875	broad.mit.edu	37	12	51450271	51450271	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:51450271C>T	uc001rxm.2	+	7	957	c.901C>T	c.(901-903)CAG>TAG	p.Q301*	LETMD1_uc010smz.1_Nonsense_Mutation_p.Q251*|LETMD1_uc010sna.1_Missense_Mutation_p.S138L|LETMD1_uc001rxl.2_Nonsense_Mutation_p.Q245*|LETMD1_uc009zlv.2_RNA|LETMD1_uc001rxs.2_Missense_Mutation_p.S138L|LETMD1_uc009zlw.2_Nonsense_Mutation_p.Q314*|LETMD1_uc001rxn.2_Nonsense_Mutation_p.Q144*|LETMD1_uc001rxo.2_RNA|LETMD1_uc001rxp.2_Nonsense_Mutation_p.Q184*|LETMD1_uc001rxq.2_Nonsense_Mutation_p.Q177*|LETMD1_uc001rxr.2_RNA|LETMD1_uc001rxt.2_Nonsense_Mutation_p.Q41*	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1	301	Mitochondrial intermembrane (Potential).|LETM1.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						GCTGACTGCTCAGGAAGTAAA	0.507		NaN											0	0	0	0.007291	0	29	81									
POU6F1	5463	broad.mit.edu	37	12	51584140	51584140	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:51584140C>T	uc001rxy.2	-	5	988	c.796G>A	c.(796-798)GAA>AAA	p.E266K	POU6F1_uc001rxz.2_Missense_Mutation_p.E266K|POU6F1_uc001rya.2_Missense_Mutation_p.E266K	NM_002702	NP_002693	Q14863	PO6F1_HUMAN	POU class 6 homeobox 1	266	Homeobox.				brain development|heart development|muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTAGCAATTTCAGTGATCTCC	0.547		NaN											0	0	0	0.013726	0	35	134									
KRT75	9119	broad.mit.edu	37	12	52827960	52827960	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:52827960C>G	uc001saj.2	-	1	151	c.129G>C	c.(127-129)GGG>GGC	p.G43G		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	43	Gly-rich.|Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GGCCCCCACTCCCTGCTGCAG	0.672		NaN											0	0	0	0.004482	0	6	48									
KRT3	3850	broad.mit.edu	37	12	53185189	53185189	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53185189T>C	uc001say.2	-	7	1402	c.1336A>G	c.(1336-1338)ATT>GTT	p.I446V		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	446	Rod.|Coil 2.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						GCCTCGGCAATGGCCGTCTGC	0.592		NaN											0	0	0	0.003755	0	32	42									
CSAD	51380	broad.mit.edu	37	12	53565116	53565116	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53565116C>G	uc001sby.2	-	7	687	c.561G>C	c.(559-561)TCG>TCC	p.S187S	CSAD_uc001sbw.2_Intron|CSAD_uc009zmt.2_Intron|CSAD_uc010snx.1_Silent_p.S214S|CSAD_uc001sbz.2_Silent_p.S187S|CSAD_uc009zmu.2_Intron|CSAD_uc001sca.3_RNA|CSAD_uc010sny.1_3'UTR	NM_015989	NP_057073	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	187					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			ovary(1)	1					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CCACCTCCTTCGATGTGAATA	0.587		NaN							Hereditary_Prostate_Cancer				0	0	0	0.004878	0	35	59									
RARG	5916	broad.mit.edu	37	12	53607344	53607344	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53607344G>A	uc001sce.2	-	8	1439	c.954C>T	c.(952-954)CTC>CTT	p.L318L	RARG_uc001scd.2_Silent_p.L307L|RARG_uc010sob.1_Silent_p.L296L|RARG_uc001scf.2_Silent_p.L318L|RARG_uc001scg.2_Silent_p.L246L|RARG_uc010soc.1_Silent_p.L197L|RARG_uc010sod.1_Silent_p.L355L	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	318	Ligand-binding.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CCAGGGGCAGGAGCTGCCCAG	0.652		NaN									OREG0021862	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00333	0	24	27									
RARG	5916	broad.mit.edu	37	12	53609125	53609125	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53609125G>A	uc001sce.2	-	5	912	c.427C>T	c.(427-429)CAG>TAG	p.Q143*	RARG_uc001scd.2_Nonsense_Mutation_p.Q132*|RARG_uc010sob.1_Nonsense_Mutation_p.Q121*|RARG_uc001scf.2_Nonsense_Mutation_p.Q143*|RARG_uc001scg.2_Nonsense_Mutation_p.Q71*|RARG_uc010soc.1_Nonsense_Mutation_p.Q22*|RARG_uc010sod.1_Nonsense_Mutation_p.Q180*	NM_000966	NP_000957	P13631	RARG_HUMAN	retinoic acid receptor, gamma isoform 1	143	NR C4-type.|Nuclear receptor.				canonical Wnt receptor signaling pathway|embryonic eye morphogenesis|embryonic hindlimb morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|regulation of cell size|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid	integral to membrane|transcription factor complex	retinoic acid receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|ovary(1)|lung(1)	4					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tazarotene(DB00799)|Tretinoin(DB00755)	CGGCAGTACTGGCAGCGATTC	0.547		NaN											0	0	0	0.004289	0	32	81									
SP1	6667	broad.mit.edu	37	12	53776403	53776403	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:53776403C>T	uc001scw.2	+	3	769	c.672C>T	c.(670-672)ATC>ATT	p.I224I	SP1_uc010sog.1_Silent_p.I217I	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	224	Transactivation domain A (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GAGGCAACATCATTGCTGCTA	0.502		NaN											0	0	0	0.01441	0	52	84									
HOXC5	3222	broad.mit.edu	37	12	54427115	54427115	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:54427115A>C	uc001sew.2	+	1	284	c.209A>C	c.(208-210)CAC>CCC	p.H70P	HOXC5_uc001set.2_Intron|HOXC4_uc001seu.2_Intron|MIR615_hsa-mir-615|MI0003628_5'Flank	NM_018953	NP_061826	Q00444	HXC5_HUMAN	homeobox C5	70					regulation of transcription from RNA polymerase II promoter	cell junction|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCCCGGGCTCACCCCGACCGC	0.672		NaN											0	0	0	0.010729	0	7	16									
OR6C2	341416	broad.mit.edu	37	12	55846762	55846762	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:55846762C>T	uc001sgz.1	+	1	765	c.765C>T	c.(763-765)TTC>TTT	p.F255F		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	255	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCTGCATCTTCATCTATATCA	0.423		NaN											0	0	0	0.009535	0	32	167									
SUOX	6821	broad.mit.edu	37	12	56397731	56397731	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56397731G>C	uc001six.2	+	6	884	c.558G>C	c.(556-558)CTG>CTC	p.L186L	SUOX_uc001siy.2_Silent_p.L186L|SUOX_uc001siz.2_Silent_p.L186L|SUOX_uc001sja.2_Silent_p.L186L	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	186	Molybdenum-pterin domain (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			ACCCAGCCCTGAAGGTCAACA	0.547		NaN											0	0	0	0.003954	0	25	24									
ESYT1	23344	broad.mit.edu	37	12	56531079	56531079	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56531079G>A	uc001sjq.2	+	17	1910	c.1860G>A	c.(1858-1860)GAG>GAA	p.E620E	ESYT1_uc001sjr.2_Silent_p.E630E	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	620						integral to membrane				ovary(4)|skin(1)	5						TGGACAGTGAGAATCCCCAGA	0.532		NaN											0	0	0	0.00623	0	34	59									
ANKRD52	283373	broad.mit.edu	37	12	56651667	56651667	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56651667C>T	uc001skm.3	-	2	146	c.56G>A	c.(55-57)CGA>CAA	p.R19Q	ANKRD52_uc001skn.1_5'Flank	NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	19	ANK 1.						protein binding			ovary(2)	2						CTCCACATCTCGGCTAAAGAT	0.637		NaN											0	0	0	0.013537	0	13	23									
PAN2	9924	broad.mit.edu	37	12	56716974	56716974	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56716974C>T	uc001skx.2	-	17	2750	c.2377G>A	c.(2377-2379)GAG>AAG	p.E793K	PAN2_uc001skw.2_5'UTR|PAN2_uc001skz.2_Missense_Mutation_p.E792K|PAN2_uc001sky.2_Missense_Mutation_p.E789K	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	793					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						AGCACACCCTCTGGACTCCCT	0.463		NaN											0	0	0	0.01441	0	100	150									
PAN2	9924	broad.mit.edu	37	12	56720504	56720504	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56720504C>T	uc001skx.2	-	7	1532	c.1159G>A	c.(1159-1161)GAC>AAC	p.D387N	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.D387N|PAN2_uc001sky.2_Missense_Mutation_p.D387N	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	387					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						TGGCTCCAGTCCAGAGGAGGC	0.587		NaN											0	0	0	0.00308	0	7	64									
PAN2	9924	broad.mit.edu	37	12	56720612	56720612	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56720612C>T	uc001skx.2	-	7	1424	c.1051G>A	c.(1051-1053)GAG>AAG	p.E351K	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.E351K|PAN2_uc001sky.2_Missense_Mutation_p.E351K	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	351					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						ACACAGCCCTCAGAATCCCCA	0.562		NaN											0	0	0	0.007291	0	28	115									
PAN2	9924	broad.mit.edu	37	12	56722297	56722297	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:56722297G>A	uc001skx.2	-	3	784	c.411C>T	c.(409-411)CTC>CTT	p.L137L	PAN2_uc001skz.2_Silent_p.L137L|PAN2_uc001sky.2_Silent_p.L137L	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	137					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CCATATACTTGAGGTTGTTCT	0.488		NaN											0	0	0	0.01441	0	54	120									
NACA	4666	broad.mit.edu	37	12	57108199	57108199	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57108199C>T	uc001slz.2	-	4	530	c.181G>A	c.(181-183)GAA>AAA	p.E61K	NACA_uc001sly.2_Missense_Mutation_p.E61K|NACA_uc009zoy.1_Missense_Mutation_p.E1924K|NACA_uc001smc.2_Missense_Mutation_p.E61K|NACA_uc001sma.2_Missense_Mutation_p.E771K|NACA_uc001smb.2_Missense_Mutation_p.E61K|NACA_uc010squ.1_RNA	NM_001113201	NP_001106672	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha	61					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			ovary(1)	1						ACTGGTTCTTCATCAATTTCA	0.398		NaN	T	BCL6	NHL								0	0	0	0.010504	0	22	78									
SDR9C7	121214	broad.mit.edu	37	12	57328012	57328012	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57328012G>A	uc010sqw.1	-	1	34	c.34C>T	c.(34-36)CGC>TGC	p.R12C		NM_148897	NP_683695	Q8NEX9	DR9C7_HUMAN	short chain dehydrogenase/reductase family 9C,	12						cytoplasm	binding|oxidoreductase activity			central_nervous_system(1)	1						TTGAACCAGCGATACATAAAT	0.547		NaN											0	0	0	0.006214	0	10	52									
STAT6	6778	broad.mit.edu	37	12	57493598	57493598	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57493598A>T	uc009zpe.2	-	15	1947	c.1696T>A	c.(1696-1698)TCA>ACA	p.S566T	STAT6_uc009zpf.2_Missense_Mutation_p.S566T|STAT6_uc001sna.2_Missense_Mutation_p.S566T|STAT6_uc010srb.1_Missense_Mutation_p.S456T|STAT6_uc010src.1_Missense_Mutation_p.S456T|STAT6_uc010srd.1_Missense_Mutation_p.S456T|STAT6_uc009zpg.2_Missense_Mutation_p.S615T	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	566	SH2.				regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						CCAATCTCTGAGTCGCTGAAG	0.582		NaN											0	0	0	0.001855	0	11	23									
INHBE	83729	broad.mit.edu	37	12	57850047	57850047	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57850047C>T	uc001snw.2	+	2	693	c.469C>T	c.(469-471)CTC>TTC	p.L157F		NM_031479	NP_113667	P58166	INHBE_HUMAN	activin beta E precursor	157					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)	3						GTCCCGCACTCTCCTGGCTGA	0.602		NaN									OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	102	177									
GLI1	2735	broad.mit.edu	37	12	57858641	57858641	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57858641G>A	uc001snx.2	+	4	457	c.379G>A	c.(379-381)GGC>AGC	p.G127S	GLI1_uc009zpp.2_RNA|GLI1_uc009zpq.2_5'UTR|GLI1_uc009zpr.1_RNA	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	127					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TCTCTCCATTGGCACCATGAG	0.557		NaN											0	0	0	0.003163	0	15	57									
DCTN2	10540	broad.mit.edu	37	12	57926780	57926780	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57926780C>T	uc001som.1	-	9	893	c.761G>A	c.(760-762)GGA>GAA	p.G254E	DCTN2_uc009zpu.1_Missense_Mutation_p.G259E|DCTN2_uc009zpv.1_Missense_Mutation_p.G167E|DCTN2_uc009zpw.1_Missense_Mutation_p.G167E|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_Missense_Mutation_p.G167E|DCTN2_uc001sop.1_Missense_Mutation_p.G167E|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Missense_Mutation_p.G254E	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	254					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						GAGACAGGCTCCCTGTAGACC	0.458		NaN											0	0	0	0.00308	0	8	17									
PIP4K2C	79837	broad.mit.edu	37	12	57994197	57994197	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:57994197G>C	uc001sou.2	+	7	921	c.790G>C	c.(790-792)GAG>CAG	p.E264Q	PIP4K2C_uc001sot.2_Missense_Mutation_p.E264Q|PIP4K2C_uc010srs.1_Missense_Mutation_p.E246Q|PIP4K2C_uc010srt.1_Missense_Mutation_p.E216Q	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	264	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					AATATTTCTGGAGAAGCTGAA	0.403		NaN											0	0	0	0.013537	0	13	46									
AGAP2	116986	broad.mit.edu	37	12	58127921	58127921	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:58127921G>A	uc001spq.2	-	5	1437	c.1437C>T	c.(1435-1437)TTC>TTT	p.F479F	AGAP2_uc001spp.2_Silent_p.F479F|AGAP2_uc001spr.2_Silent_p.F143F	NM_001122772	NP_001116244	Q99490	AGAP2_HUMAN	centaurin, gamma 1 isoform PIKE-L	479	G domain.				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			central_nervous_system(3)|breast(2)	5						CCTCCAGGCTGAAGACGAAGA	0.587		NaN											0	0	0	0.010504	0	20	19									
MARCH9	92979	broad.mit.edu	37	12	58152013	58152013	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:58152013G>T	uc001spx.1	+	3	1048	c.636G>T	c.(634-636)AAG>AAT	p.K212N	MARCH9_uc001spy.2_Missense_Mutation_p.K99N	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	membrane-associated RING-CH protein IX	212						Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding				0	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CTTCAGCCAAGTGGCAACGAC	0.542		NaN											1	0	1.96895e-08	0.00278	2.03555e-08	23	62									
MON2	23041	broad.mit.edu	37	12	62861092	62861092	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:62861092C>T	uc001sre.2	+	1	496	c.105C>T	c.(103-105)GTC>GTT	p.V35V	MON2_uc009zqj.2_Silent_p.V35V|MON2_uc010ssl.1_5'UTR|MON2_uc010ssm.1_Silent_p.V35V|MON2_uc010ssn.1_Silent_p.V35V|MON2_uc001srd.1_Silent_p.V35V	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	35					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TCCCACCTGTCAAAGAGGTAA	0.542		NaN											0	0	0	0.008871	0	20	70									
LEMD3	23592	broad.mit.edu	37	12	65564632	65564632	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:65564632C>T	uc001ssl.1	+	1	1262	c.1256C>T	c.(1255-1257)TCT>TTT	p.S419F	LEMD3_uc009zqo.1_Missense_Mutation_p.S419F	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	419					negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GTGGCCGCCTCTAGTTCACTC	0.502		NaN											0	0	0	0.010504	0	20	65									
KCNMB4	27345	broad.mit.edu	37	12	70760748	70760748	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:70760748C>T	uc001svx.2	+	1	687	c.234C>T	c.(232-234)GGC>GGT	p.G78G		NM_014505	NP_055320	Q86W47	KCMB4_HUMAN	calcium-activated potassium channel beta 4	78	Extracellular (Potential).				detection of calcium ion|platelet activation|regulation of action potential in neuron|regulation of neurotransmitter secretion|regulation of vasoconstriction|synaptic transmission	voltage-gated potassium channel complex	calcium-activated potassium channel activity|protein binding				0	Renal(347;0.236)		Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			ACTGCAGGGGCACCTCGCAGT	0.627		NaN											0	0	0	0.014323	0	23	78									
OSBPL8	114882	broad.mit.edu	37	12	76788453	76788453	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:76788453C>T	uc001sye.1	-	9	1209	c.729G>A	c.(727-729)TTG>TTA	p.L243L	OSBPL8_uc001syf.1_Silent_p.L201L|OSBPL8_uc001syg.1_Silent_p.L201L|OSBPL8_uc001syh.1_Silent_p.L218L	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	243	PH.				lipid transport		lipid binding			ovary(1)	1						CTCGGATGATCAAATAACTGC	0.323		NaN											0	0	0	0.003271	0	31	39									
NAV3	89795	broad.mit.edu	37	12	78513043	78513043	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:78513043G>C	uc001syp.2	+	15	3240	c.3067G>C	c.(3067-3069)GAG>CAG	p.E1023Q	NAV3_uc001syo.2_Missense_Mutation_p.E1023Q|NAV3_uc010sub.1_Missense_Mutation_p.E523Q|NAV3_uc009zsf.2_Missense_Mutation_p.E31Q	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1023						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CAAAGCTTCTGAGAAAGGAAA	0.418		NaN								HNSCC(70;0.22)			0	0	0	0.010771	0	42	211									
NAV3	89795	broad.mit.edu	37	12	78513245	78513245	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:78513245C>T	uc001syp.2	+	15	3442	c.3269C>T	c.(3268-3270)TCT>TTT	p.S1090F	NAV3_uc001syo.2_Missense_Mutation_p.S1090F|NAV3_uc010sub.1_Missense_Mutation_p.S590F|NAV3_uc009zsf.2_Missense_Mutation_p.S98F	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1090	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ACAAGTGGCTCTGCAACACTG	0.483		NaN								HNSCC(70;0.22)			0	0	0	0.004007	0	13	62									
ACSS3	79611	broad.mit.edu	37	12	81536974	81536974	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:81536974C>T	uc001szl.1	+	5	960	c.869C>T	c.(868-870)TCA>TTA	p.S290L	ACSS3_uc001szm.1_Missense_Mutation_p.S289L	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	290						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCTGTTCTTTCAGAACACCCA	0.453		NaN											0	0	0	0.01441	0	97	20									
KERA	11081	broad.mit.edu	37	12	91445283	91445283	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:91445283G>A	uc001tbl.2	-	3	1518	c.899C>T	c.(898-900)TCT>TTT	p.S300F		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	300	LRR 10.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						ACATATTACAGAGACATTCAC	0.428		NaN											0	0	0	0.009535	0	31	39									
UBE2N	7334	broad.mit.edu	37	12	93804976	93804976	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:93804976C>T	uc001tcp.2	-	2	496	c.130G>A	c.(130-132)GAT>AAT	p.D44N		NM_003348	NP_003339	P61088	UBE2N_HUMAN	ubiquitin-conjugating enzyme E2N	44					DNA double-strand break processing|double-strand break repair via homologous recombination|histone ubiquitination|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of DNA repair|positive regulation of histone modification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity|postreplication repair|protein K63-linked ubiquitination|proteolysis|regulation of histone ubiquitination|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus|UBC13-MMS2 complex|UBC13-UEV1A complex|ubiquitin ligase complex	ATP binding|ubiquitin binding|ubiquitin-protein ligase activity				0						AAGGGGGAATCCTGAGGGCCA	0.478		NaN						Direct_reversal_of_damage|Rad6_pathway					0	0	0	0.01441	0	51	92									
CCDC38	120935	broad.mit.edu	37	12	96284667	96284667	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:96284667C>G	uc001tek.1	-	9	1048	c.814G>C	c.(814-816)GAG>CAG	p.E272Q		NM_182496	NP_872302	Q502W7	CCD38_HUMAN	coiled-coil domain containing 38	272										skin(1)	1						CTCCCGGACTCCTCAAGGATG	0.443		NaN											0	0	0	0.00632	0	27	45									
HAL	3034	broad.mit.edu	37	12	96382019	96382019	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:96382019C>T	uc001tem.1	-	11	1153	c.856_splice	c.e11-1	p.V286_splice	HAL_uc009zti.1_Splice_Site|HAL_uc010suw.1_Splice_Site_p.V78_splice|HAL_uc010sux.1_Splice_Site_p.V286_splice	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase						biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	CTTCTAGCACCTATAGAATGA	0.308		NaN											0	0	0	0.01441	0	105	156									
C12orf63	374467	broad.mit.edu	37	12	97051853	97051853	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:97051853C>T	uc001tet.1	+	4	647	c.569C>T	c.(568-570)TCT>TTT	p.S190F		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	190										skin(6)|ovary(1)	7						ACACTAGTATCTCTTGCCATT	0.313		NaN											0	0	0	0.012213	0	31	115									
UHRF1BP1L	23074	broad.mit.edu	37	12	100489579	100489579	+	Missense_Mutation	SNP	G	G	C	rs12824229		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:100489579G>C	uc001tgq.2	-	7	935	c.706C>G	c.(706-708)CTA>GTA	p.L236V	UHRF1BP1L_uc001tgr.2_Missense_Mutation_p.L236V|UHRF1BP1L_uc001tgp.2_5'Flank	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	236										ovary(2)	2						TCCAATATTAGAACTAACTTT	0.303		NaN											0	0	0	0.006122	0	18	53									
SLC5A8	160728	broad.mit.edu	37	12	101584349	101584349	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:101584349T>C	uc001thz.3	-	6	1120	c.730A>G	c.(730-732)ACA>GCA	p.T244A		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	244	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						ATAATAATTGTCCAGAAGGTG	0.373		NaN											0	0	0	0.00632	0	30	96									
CHPT1	56994	broad.mit.edu	37	12	102091702	102091702	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:102091702G>A	uc001tin.2	+	1	286	c.63G>A	c.(61-63)CTG>CTA	p.L21L	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Silent_p.L21L	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	21					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						GCGAGCCGCTGAGCGCGGCGC	0.791		NaN											0	0	0	0.009096	0	4	1									
ALKBH2	121642	broad.mit.edu	37	12	109526080	109526080	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:109526080G>A	uc001tnx.2	-	4	1110	c.717C>T	c.(715-717)CCC>CCT	p.P239P	ALKBH2_uc001tny.2_Silent_p.P239P|ALKBH2_uc010sxj.1_Silent_p.P239P|ALKBH2_uc009zvd.2_3'UTR|ALKBH2_uc010sxk.1_3'UTR	NM_001145374	NP_001138846	Q6NS38	ALKB2_HUMAN	AlkB homolog 2	239	Fe2OG dioxygenase.				DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0					Vitamin C(DB00126)	TCTTTCTCACGGGAAGACTGT	0.483		NaN						Direct_reversal_of_damage					0	0	0	0.01441	0	49	193									
RAD9B	144715	broad.mit.edu	37	12	110956540	110956540	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:110956540C>G	uc001trf.3	+	7	793	c.655C>G	c.(655-657)CAA>GAA	p.Q219E	RAD9B_uc001trg.3_Missense_Mutation_p.Q219E|RAD9B_uc010sya.1_Missense_Mutation_p.Q150E|RAD9B_uc001tre.3_Missense_Mutation_p.Q147E|RAD9B_uc001trd.3_Missense_Mutation_p.Q61E	NM_152442	NP_689655	Q6WBX8	RAD9B_HUMAN	RAD9 homolog B	216					cell cycle checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding			pancreas(1)|skin(1)	2						TGACTTCTTTCAAATTGGAAT	0.279		NaN											0	0	0	0.010771	0	42	57									
CCDC63	160762	broad.mit.edu	37	12	111290763	111290763	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:111290763C>T	uc001trv.1	+	2	200	c.5C>T	c.(4-6)TCT>TTT	p.S2F	CCDC63_uc009zvt.1_Intron|CCDC63_uc010sye.1_Intron|CCDC63_uc001trw.1_Intron	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	2										skin(6)|ovary(1)|pancreas(1)	8						TTCAAGATGTCTGTGGTAGGT	0.313		NaN											0	0	0	0.004656	0	27	32									
DTX1	1840	broad.mit.edu	37	12	113531504	113531504	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:113531504G>C	uc001tuk.1	+	4	1500	c.1164G>C	c.(1162-1164)AAG>AAC	p.K388N		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	388					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						ACCTTAAAAAGAGTACGCCCT	0.582		NaN											0	0	0	0.013537	0	11	17									
DTX1	1840	broad.mit.edu	37	12	113532921	113532921	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:113532921G>A	uc001tuk.1	+	7	1797	c.1461G>A	c.(1459-1461)ATG>ATA	p.M487I		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	487					negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						CTGGGAAGATGGAGTTCCACC	0.642		NaN											0	0	0	0.010504	0	21	33									
SLC24A6	80024	broad.mit.edu	37	12	113737681	113737681	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:113737681G>A	uc001tvc.2	-	16	1866	c.1656C>T	c.(1654-1656)CTC>CTT	p.L552L	SLC24A6_uc001tuz.2_Silent_p.L257L|SLC24A6_uc001tva.2_RNA|SLC24A6_uc001tvb.2_Silent_p.L290L	NM_024959	NP_079235	Q6J4K2	NCKX6_HUMAN	solute carrier family 24 member 6 precursor	552	Extracellular (Potential).				response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			central_nervous_system(1)	1						AGACTCTGCTGAGCTGGAAGC	0.577		NaN											0	0	0	0.010818	0	25	37									
TBX3	6926	broad.mit.edu	37	12	115120680	115120680	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:115120680G>A	uc001tvt.1	-	1	1290	c.326C>T	c.(325-327)GCT>GTT	p.A109V	TBX3_uc001tvu.1_Missense_Mutation_p.A109V|TBX3_uc010syw.1_Missense_Mutation_p.A109V	NM_016569	NP_057653	O15119	TBX3_HUMAN	T-box 3 protein isoform 2	109	T-box; first part.				anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			ovary(2)|skin(1)	3	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		AAGTTCTTTAGCCTCCAGGTG	0.592		NaN											0	0	0	0.013726	0	31	49									
MED13L	23389	broad.mit.edu	37	12	116418744	116418744	+	Splice_Site	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:116418744C>G	uc001tvw.2	-	23	5231	c.5176_splice	c.e23-1	p.I1726_splice		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		AAGGCACAATCTAAAGACACA	0.378		NaN											0	0	0	0.007413	0	20	45									
VSIG10	54621	broad.mit.edu	37	12	118511775	118511775	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:118511775C>T	uc001tws.2	-	5	1282	c.948G>A	c.(946-948)GAG>GAA	p.E316E		NM_019086	NP_061959	Q8N0Z9	VSI10_HUMAN	V-set and immunoglobulin domain containing 10	316	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane					0						TCTTCATGGGCTCAGAGAGAA	0.527		NaN											0	0	0	0.00499	0	17	23									
CCDC60	160777	broad.mit.edu	37	12	119954484	119954484	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:119954484G>A	uc001txe.2	+	8	1405	c.940G>A	c.(940-942)GAA>AAA	p.E314K	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	314										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		AGTCACAATAGAAAATGGGAT	0.433		NaN											0	0	0	0.004007	0	16	58									
COX6A1	1337	broad.mit.edu	37	12	120876184	120876184	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:120876184C>G	uc001tyf.1	+	2	132	c.106C>G	c.(106-108)CGC>GGC	p.R36G		NM_004373	NP_004364	P12074	CX6A1_HUMAN	cytochrome c oxidase subunit VIa polypeptide 1	36					respiratory electron transport chain	mitochondrial respiratory chain complex IV	cytochrome-c oxidase activity				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCCGCAGCTCGCATGTGGAA	0.637		NaN											0	0	0	0.008291	0	8	21									
SFRS9	8683	broad.mit.edu	37	12	120903591	120903591	+	Splice_Site	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:120903591C>G	uc001tyi.2	-	2	335	c.189_splice	c.e2-1	p.R63_splice	SFRS9_uc009zwy.2_Intron	NM_003769	NP_003760	Q13242	SRSF9_HUMAN	splicing factor, arginine/serine-rich 9						mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|RNA binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCTGCATCTCTAAAAAAAAC	0.453		NaN											0	0	0	0.012319	0	20	42									
RNF10	9921	broad.mit.edu	37	12	120995412	120995412	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:120995412G>A	uc001typ.3	+	6	1377	c.894G>A	c.(892-894)AAG>AAA	p.K298K	RNF10_uc010szk.1_RNA|RNF10_uc001tyq.3_Silent_p.K204K	NM_014868	NP_055683	Q8N5U6	RNF10_HUMAN	ring finger protein 10	298					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGCTGATGAAGAGGGAGAAAG	0.448		NaN											0	0	0	0.004878	0	37	190									
P2RX7	5027	broad.mit.edu	37	12	121615003	121615003	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:121615003C>T	uc001tzm.2	+	10	1122	c.1026C>T	c.(1024-1026)TCC>TCT	p.S342S	P2RX7_uc001tzn.2_Silent_p.S252S|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_Silent_p.S53S|P2RX7_uc001tzq.2_Silent_p.S172S	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	342						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAACCCTCTCCTACTTCGGTC	0.468		NaN											0	0	0	0.01441	0	57	76									
CLIP1	6249	broad.mit.edu	37	12	122817644	122817644	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:122817644C>G	uc001ucg.1	-	14	2863	c.2757G>C	c.(2755-2757)CTG>CTC	p.L919L	CLIP1_uc001uch.1_Silent_p.L908L|CLIP1_uc001uci.1_Silent_p.L873L|CLIP1_uc001ucj.1_Silent_p.L494L	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	919	Potential.				mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		TTGCCTTTATCAGCTGCTCTT	0.343		NaN											0	0	0	0.00499	0	18	36									
KNTC1	9735	broad.mit.edu	37	12	123089504	123089504	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:123089504C>G	uc001ucv.2	+	50	5419	c.5256C>G	c.(5254-5256)CTC>CTG	p.L1752L	KNTC1_uc010taf.1_Intron	NM_014708	NP_055523	P50748	KNTC1_HUMAN	Rough Deal homolog, centromere/kinetochore	1752					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			ovary(5)|kidney(3)|lung(1)|central_nervous_system(1)	10	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		AAGCTGTGCTCATAGCCCACA	0.438		NaN											0	0	0	0.008291	0	10	13									
GPR81	27198	broad.mit.edu	37	12	123214722	123214722	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:123214722G>A	uc001ucz.2	-	1	408	c.165C>T	c.(163-165)TTC>TTT	p.F55F	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	55	Helical; Name=2; (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.N56fs*6(1)			0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		CGGCCAAATTGAAAAGGTAAA	0.527		NaN											0	0	0	0.004007	0	16	11									
SETD8	387893	broad.mit.edu	37	12	123868753	123868753	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:123868753G>A	uc001uew.2	+	1	50	c.8G>A	c.(7-9)AGA>AAA	p.R3K	SETD8_uc001uex.2_5'UTR	NM_020382	NP_065115	Q9NQR1	SETD8_HUMAN	SET domain-containing 8	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		GCCATGGCTAGAGGTATTTGC	0.662		NaN											0	0	0	0.000602	0	5	12									
DDX55	57696	broad.mit.edu	37	12	124104609	124104609	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:124104609G>T	uc001ufi.2	+	14	1749	c.1725G>T	c.(1723-1725)GAG>GAT	p.E575D	DDX55_uc001ufk.2_Missense_Mutation_p.E428D|DDX55_uc001ufl.2_Missense_Mutation_p.E182D	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	575							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		AAGAATTTGAGAAGGGCTTGT	0.393		NaN											1	0	1.40151e-16	0.010504	1.47563e-16	21	90									
NCOR2	9612	broad.mit.edu	37	12	124979754	124979754	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:124979754G>A	uc010tba.1	-	1	161	c.44C>T	c.(43-45)ACT>ATT	p.T15I	NCOR2_uc010tay.1_Missense_Mutation_p.T15I|NCOR2_uc010taz.1_Missense_Mutation_p.T15I|NCOR2_uc010tbb.1_Missense_Mutation_p.T15I|NCOR2_uc010tbc.1_Missense_Mutation_p.T15I|NCOR2_uc001ugj.1_Missense_Mutation_p.T15I|NCOR2_uc001ugk.1_Missense_Mutation_p.T15I	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	15					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCGGGGCTCAGTGGCCCTCCA	0.642		NaN											0	0	0	0.00308	0	7	34									
UBC	7316	broad.mit.edu	37	12	125398075	125398075	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:125398075C>T	uc001ugs.3	-	2	691	c.243G>A	c.(241-243)GTG>GTA	p.V81V	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Silent_p.V81V|UBC_uc001ugt.2_Silent_p.V81V|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Intron	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	81	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		TGAGTGTCTTCACGAAGATTT	0.542		NaN											0	0	0	0.01441	0	110	169									
MMP17	4326	broad.mit.edu	37	12	132322757	132322757	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:132322757C>T	uc001ujc.1	+	2	276	c.177C>T	c.(175-177)TTC>TTT	p.F59F	MMP17_uc001ujd.1_5'UTR	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	59					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		TAAGCAGGTTCGGTTACCTGC	0.642		NaN											0	0	0	0.010504	0	18	19									
ULK1	8408	broad.mit.edu	37	12	132380364	132380364	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:132380364T>C	uc001uje.2	+	3	509	c.241T>C	c.(241-243)TTC>CTC	p.F81L		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	81	Protein kinase.				autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		CCTGTACGACTTCCAGGTAAG	0.617		NaN											0	0	0	0.004482	0	7	57									
POLE	5426	broad.mit.edu	37	12	133226443	133226443	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:133226443C>T	uc001uks.1	-	30	3659	c.3615G>A	c.(3613-3615)CCG>CCA	p.P1205P	POLE_uc001ukr.1_Silent_p.P9P|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.P1178P	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1205					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CACTTGGCCTCGGACTGTCTT	0.493		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.008291	0	11	34									
PGAM5	192111	broad.mit.edu	37	12	133294683	133294683	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:133294683C>T	uc009zyv.2	+	5	723	c.696C>T	c.(694-696)AAC>AAT	p.N232N	PGAM5_uc010tbr.1_RNA|PGAM5_uc001uku.2_Silent_p.N232N	NM_138575	NP_612642	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	232						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		GTCACGCCAACGTCATCCGCT	0.562		NaN											0	0	0	0.008291	0	10	53									
MPHOSPH8	54737	broad.mit.edu	37	13	20208066	20208066	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:20208066G>C	uc001umh.2	+	1	187	c.178G>C	c.(178-180)GAG>CAG	p.E60Q	MPHOSPH8_uc001umf.1_Missense_Mutation_p.E60Q|MPHOSPH8_uc001umg.2_Missense_Mutation_p.E60Q	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	60	Chromo.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		GGATGTGTTCGAGGTGGAGAA	0.657		NaN											0	0	0	0.004672	0	3	5									
ZMYM5	9205	broad.mit.edu	37	13	20425496	20425496	+	Silent	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:20425496A>G	uc010tcn.1	-	4	850	c.585T>C	c.(583-585)CCT>CCC	p.P195P	ZMYM5_uc001umm.1_Silent_p.P19P|ZMYM5_uc001umn.2_Silent_p.P195P|ZMYM5_uc001umo.2_Silent_p.P195P	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	195						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		ACTGCTTACCAGGACTATGAT	0.383		NaN											0	0	0	0.007413	0	20	78									
XPO4	64328	broad.mit.edu	37	13	21371070	21371070	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:21371070C>T	uc001unq.3	-	17	2485	c.2449G>A	c.(2449-2451)GAG>AAG	p.E817K		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	exportin 4	817					protein transport	cytoplasm|nucleus	protein binding			large_intestine(1)|ovary(1)|kidney(1)	3		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		TGGGTAGCCTCAGCAATGCCA	0.428		NaN											0	0	0	0.007413	0	18	68									
MRP63	78988	broad.mit.edu	37	13	21751241	21751241	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:21751241C>T	uc001unw.2	+	2	676	c.186C>T	c.(184-186)CAC>CAT	p.H62H	SKA3_uc001unt.2_5'Flank|SKA3_uc001unv.2_5'Flank|SKA3_uc001unu.2_5'Flank	NM_024026	NP_076931	Q9BQC6	RT63_HUMAN	mitochondrial ribosomal protein 63	62											0		all_cancers(29;2.76e-20)|all_epithelial(30;2.97e-18)|all_lung(29;4.58e-16)|Lung SC(185;0.0262)|Breast(139;0.147)		all cancers(112;9.43e-05)|Epithelial(112;0.000285)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|Lung(94;0.0932)		AGCGCGGCCACGCCGCGGTGC	0.642		NaN											0	0	0	0.001168	0	5	25									
UBL3	5412	broad.mit.edu	37	13	30341760	30341760	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:30341760G>C	uc001usp.2	-	4	1441	c.296C>G	c.(295-297)TCT>TGT	p.S99C		NM_007106	NP_009037	O95164	UBL3_HUMAN	ubiquitin-like 3 precursor	99						intracellular|plasma membrane					0		Lung SC(185;0.0281)		all cancers(112;0.0598)|GBM - Glioblastoma multiforme(144;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.147)		CTTACCTTGAGAGTTTGGCTC	0.408		NaN											0	0	0	0.004878	0	36	39									
USPL1	10208	broad.mit.edu	37	13	31211905	31211905	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:31211905C>T	uc001utc.2	+	5	1325	c.893C>T	c.(892-894)TCA>TTA	p.S298L	USPL1_uc001utb.2_Missense_Mutation_p.S117L|USPL1_uc001utd.2_5'UTR|USPL1_uc001ute.1_5'UTR	NM_005800	NP_005791	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	298					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			pancreas(2)|skin(1)	3		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AAACTTACCTCAGAAATATTT	0.348		NaN											0	0	0	0.009535	0	33	85									
N4BP2L2	10443	broad.mit.edu	37	13	33018001	33018001	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:33018001T>C	uc010abe.1	-	7	695	c.673A>G	c.(673-675)AAA>GAA	p.K225E	N4BP2L2_uc001uug.2_Missense_Mutation_p.K108E|N4BP2L2_uc010abd.1_Missense_Mutation_p.K138E|N4BP2L2_uc001uuh.2_Missense_Mutation_p.K56E|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.K210E	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TTCCATCTTTTTTCTTTATAT	0.343		NaN											0	0	0	0.009096	0	4	8									
DCLK1	9201	broad.mit.edu	37	13	36686315	36686315	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:36686315C>G	uc001uvf.2	-	3	647	c.414G>C	c.(412-414)AAG>AAC	p.K138N		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	138	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		ACTCCAGTTTCTTGAAGGGCT	0.428		NaN											0	0	0	0.005443	0	26	54									
SPG20	23111	broad.mit.edu	37	13	36909157	36909157	+	Splice_Site	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:36909157C>G	uc001uvn.2	-	3	1080	c.810_splice	c.e3+1	p.Q270_splice	SPG20_uc010ten.1_Intron|SPG20_uc001uvm.2_Splice_Site_p.Q270_splice|SPG20_uc001uvo.2_Splice_Site_p.Q270_splice|SPG20_uc001uvq.2_Splice_Site_p.Q270_splice|SPG20_uc001uvp.2_Splice_Site_p.Q270_splice	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin						cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		CTTTCGCTTACCTGAAGAAAC	0.378		NaN											0	0	0	0.009718	0	39	65									
TSC22D1	8848	broad.mit.edu	37	13	45147906	45147906	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:45147906G>A	uc001uzn.3	-	1	2796	c.2305C>T	c.(2305-2307)CAA>TAA	p.Q769*	TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	769	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		ATCCCAGTTTGAGCAGGTGGA	0.493		NaN											0	0	0	0.006122	0	19	62									
TSC22D1	8848	broad.mit.edu	37	13	45149590	45149590	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:45149590C>T	uc001uzn.3	-	1	1112	c.621G>A	c.(619-621)CAG>CAA	p.Q207Q	TSC22D1_uc001uzo.1_Silent_p.Q207Q	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	207	His-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		TCACAACATTCTGTTGTGGAA	0.353		NaN											0	0	0	0.014323	0	22	19									
KCTD4	386618	broad.mit.edu	37	13	45768414	45768414	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:45768414C>T	uc001uzx.3	-	2	693	c.289G>A	c.(289-291)GAA>AAA	p.E97K	GTF2F2_uc001uzv.2_Intron|GTF2F2_uc001uzw.2_Intron	NM_198404	NP_940686	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerisation domain	97	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		AATAGAAGTTCTCCATTTCGT	0.443		NaN											0	0	0	0.01441	0	86	127									
LCP1	3936	broad.mit.edu	37	13	46701847	46701847	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:46701847G>C	uc001vaz.3	-	16	1889	c.1763C>G	c.(1762-1764)TCT>TGT	p.S588C	LCP1_uc010ack.2_Missense_Mutation_p.S157C|LCP1_uc001vay.3_Missense_Mutation_p.S185C|LCP1_uc001vba.3_Missense_Mutation_p.S588C	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	588	Actin-binding 2.|CH 4.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TCGGGCCATAGAGATGGCATA	0.493		NaN	T	BCL6	NHL 								0	0	0	0.01441	0	59	36									
LPAR6	10161	broad.mit.edu	37	13	48985612	48985612	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:48985612G>A	uc010acu.2	-	1	2042	c.948C>T	c.(946-948)TTC>TTT	p.F316F	RB1_uc001vcb.2_Intron|LPAR6_uc001vcc.1_Intron|LPAR6_uc001vce.2_Silent_p.F316F|LPAR6_uc001vcf.2_Silent_p.F316F	NM_001162498	NP_001155970	P43657	LPAR6_HUMAN	G-protein coupled purinergic receptor P2Y5	316	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.?(4)		ovary(4)	4						GAACTTCAGAGAATCTGAAGT	0.338		NaN											0	0	0	0.011902	0	46	61									
RCBTB2	1102	broad.mit.edu	37	13	49085972	49085972	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:49085972G>A	uc001vch.2	-	9	1088	c.717C>T	c.(715-717)CTC>CTT	p.L239L	RCBTB2_uc010tgg.1_Silent_p.L244L|RCBTB2_uc001vci.2_Silent_p.L215L|RCBTB2_uc010tgh.1_Missense_Mutation_p.S13L|RCBTB2_uc001vcj.2_Silent_p.L243L|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_Silent_p.L215L	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	239	RCC1 4.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		CACTGTTGCCGAGTCCAAGCT	0.527		NaN											0	0	0	0.013537	0	12	31									
ATP7B	540	broad.mit.edu	37	13	52548420	52548420	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:52548420C>T	uc001vfw.2	-	2	1093	c.936G>A	c.(934-936)CAG>CAA	p.Q312Q	ATP7B_uc010adv.2_Silent_p.Q312Q|ATP7B_uc001vfx.2_Silent_p.Q312Q|ATP7B_uc001vfy.2_Intron|ATP7B_uc010tgt.1_Silent_p.Q312Q|ATP7B_uc010tgu.1_Silent_p.Q312Q|ATP7B_uc010tgv.1_Silent_p.Q312Q|ATP7B_uc010tgw.1_Silent_p.Q280Q	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	312	HMA 3.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CGATAGCCCTCTGCAGAGCCA	0.502		NaN							Wilson_disease				0	0	0	0.008361	0	29	65									
OLFM4	10562	broad.mit.edu	37	13	53624514	53624514	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:53624514C>G	uc001vhl.2	+	5	1141	c.1141C>G	c.(1141-1143)CAA>GAA	p.Q381E	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	381	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		TGTTGCTTGGCAAGATATTGA	0.413		NaN											0	0	0	0.01441	0	57	149									
PCDH17	27253	broad.mit.edu	37	13	58208221	58208221	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:58208221C>T	uc001vhq.1	+	1	2433	c.1541C>T	c.(1540-1542)TCG>TTG	p.S514L	PCDH17_uc010aec.1_Missense_Mutation_p.S514L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	514	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCCTGCCCTCGCACATCGGC	0.592		NaN											0	0	0	0.00333	0	23	19									
PCDH20	64881	broad.mit.edu	37	13	61985735	61985735	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:61985735G>A	uc001vid.3	-	2	2861	c.2497C>T	c.(2497-2499)CTC>TTC	p.L833F	PCDH20_uc010thj.1_Missense_Mutation_p.L833F	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	806	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GTGGAGTGGAGAGGCTCGGGA	0.413		NaN											0	0	0	0.010818	0	33	50									
DACH1	1602	broad.mit.edu	37	13	72134058	72134058	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:72134058G>T	uc010thn.1	-	6	1752	c.1329C>A	c.(1327-1329)GCC>GCA	p.A443A	DACH1_uc010tho.1_Intron|DACH1_uc010thp.1_Intron	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	495					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		CCAGAGAGGGGGCAGGTGAGG	0.542		NaN											1	0	0.00116845	0.001168	0.00118816	5	13									
KCTD12	115207	broad.mit.edu	37	13	77459558	77459558	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:77459558C>T	uc010aeu.1	-	1	983	c.726G>A	c.(724-726)ACG>ACA	p.T242T	KCTD12_uc001vka.1_Silent_p.T242T	NM_138444	NP_612453	Q96CX2	KCD12_HUMAN	potassium channel tetramerisation domain	242						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(1)	1		Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.0499)		TGGCCAGCGACGTCTTTCCGC	0.647		NaN									OREG0022449	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	8	2									
MYCBP2	23077	broad.mit.edu	37	13	77651516	77651516	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:77651516G>A	uc001vkf.2	-	68	11468	c.11377C>T	c.(11377-11379)CTG>TTG	p.L3793L	MYCBP2_uc010aev.2_Silent_p.L3197L|MYCBP2_uc001vke.2_Silent_p.L413L	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3793	DOC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTGGAATCCAGATCAACCTGG	0.423		NaN											0	0	0	0.010504	0	21	25									
GPC6	10082	broad.mit.edu	37	13	93879803	93879803	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:93879803G>A	uc001vlt.2	+	1	726	c.94G>A	c.(94-96)GAG>AAG	p.E32K	GPC6_uc010tig.1_Missense_Mutation_p.E32K	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	32						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GAGCTGCGGAGAGGTCCGCCA	0.672		NaN									OREG0022460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	8	15									
ATP11A	23250	broad.mit.edu	37	13	113508799	113508799	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:113508799C>T	uc001vsi.3	+	19	2286	c.2198C>T	c.(2197-2199)ACG>ATG	p.T733M	ATP11A_uc001vsj.3_Missense_Mutation_p.T733M|ATP11A_uc001vsm.1_Missense_Mutation_p.T609M|ATP11A_uc010ago.2_RNA	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	733	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CTGAGCAAGACGGTCCTGCGC	0.657		NaN											0	0	0	0.001855	0	13	11									
LAMP1	3916	broad.mit.edu	37	13	113976673	113976673	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:113976673C>T	uc001vtm.1	+	9	1472	c.1191C>T	c.(1189-1191)CTC>CTT	p.L397L	LAMP1_uc010tka.1_Silent_p.L344L	NM_005561	NP_005552	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	397	Helical; (Potential).					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				central_nervous_system(2)	2	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			GGCTGGTCCTCATCGTCCTCA	0.627		NaN											0	0	0	0.013726	0	30	15									
CCNB1IP1	57820	broad.mit.edu	37	14	20781943	20781943	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:20781943G>C	uc001vwv.2	-	6	964	c.315C>G	c.(313-315)CTC>CTG	p.L105L	CCNB1IP1_uc001vww.2_Silent_p.L105L|CCNB1IP1_uc001vwx.2_Silent_p.L105L|CCNB1IP1_uc001vwy.2_Silent_p.L105L|CCNB1IP1_uc001vwz.2_Silent_p.L105L	NM_182851	NP_878271	Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1 isoform 3	105						chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		ATTCTTGATAGAGACGTTCCT	0.338		NaN	T	HMGA2	leiomyoma								0	0	0	0.010729	0	11	37									
OSGEP	55644	broad.mit.edu	37	14	20916914	20916914	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:20916914G>A	uc001vxf.2	-	6	970	c.614C>T	c.(613-615)TCA>TTA	p.S205L		NM_017807	NP_060277	Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	205					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		CAGGATCCCTGAGAATGAGAC	0.438		NaN											0	0	0	0.007413	0	16	42									
FLJ10357	55701	broad.mit.edu	37	14	21549964	21549964	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:21549964G>T	uc001vzp.2	+	14	2966	c.2937G>T	c.(2935-2937)CAG>CAT	p.Q979H	FLJ10357_uc001vzo.1_Missense_Mutation_p.Q58H|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_Missense_Mutation_p.Q265H	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	979					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		GAGGGGCCCAGTGGGGGCCCC	0.711		NaN											1	0	0.000602214	0.000602	0.000613236	5	1									
HNRNPC	3183	broad.mit.edu	37	14	21699232	21699232	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:21699232C>T	uc001vzy.2	-	4	486	c.242_splice	c.e4-1	p.D81_splice	HNRNPC_uc001vzw.2_Splice_Site_p.D81_splice|HNRNPC_uc001wad.2_Intron|HNRNPC_uc001vzx.2_Intron|HNRNPC_uc001vzz.2_Splice_Site_p.D81_splice|HNRNPC_uc001waa.2_Splice_Site_p.D81_splice|HNRNPC_uc010ail.2_Splice_Site_p.D81_splice|HNRNPC_uc010tlq.1_Splice_Site|HNRNPC_uc001wab.2_Splice_Site_p.D81_splice|HNRNPC_uc001wac.2_Splice_Site_p.D81_splice|HNRNPC_uc010tlr.1_5'Flank|HNRNPC_uc001waf.2_Splice_Site_p.D81_splice|HNRNPC_uc001wae.2_Splice_Site_p.D81_splice	NM_031314	NP_112604	P07910	HNRPC_HUMAN	heterogeneous nuclear ribonucleoprotein C							catalytic step 2 spliceosome|nucleoplasm	identical protein binding|nucleotide binding|RNA binding				0	all_cancers(95;0.00176)		Epithelial(56;1.08e-06)|all cancers(55;8.95e-06)	GBM - Glioblastoma multiforme(265;0.00783)		AGGTTAATATCTGAAAAACAA	0.338		NaN											0	0	0	0.007413	0	19	39									
CHD8	57680	broad.mit.edu	37	14	21862166	21862166	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:21862166C>T	uc001was.1	-	32	5045	c.4951G>A	c.(4951-4953)GAT>AAT	p.D1651N	CHD8_uc001war.1_Missense_Mutation_p.D1547N|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1930					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AGCTCCCCATCATGCCGAACA	0.552		NaN											0	0	0	0.001855	0	14	20									
METTL3	56339	broad.mit.edu	37	14	21967731	21967731	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:21967731C>T	uc001wbc.2	-	8	1449	c.1357G>A	c.(1357-1359)GAT>AAT	p.D453N	METTL3_uc001wbb.2_Missense_Mutation_p.D298N	NM_019852	NP_062826	Q86U44	MTA70_HUMAN	methyltransferase like 3	453					gene expression	nuclear speck	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|RNA binding			pancreas(1)|skin(1)	2	all_cancers(95;0.000628)		Epithelial(56;6.61e-06)	GBM - Glioblastoma multiforme(265;0.0146)		ATAATTTCATCTACCCGTTCA	0.423		NaN											0	0	0	0.008361	0	31	76									
MYH7	4625	broad.mit.edu	37	14	23887435	23887435	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:23887435C>T	uc001wjx.2	-	30	4259	c.4153G>A	c.(4153-4155)GAG>AAG	p.E1385K	MIR208B_hsa-mir-208b|MI0005570_5'Flank	NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1385	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCTCGAGCTCCTCAGTCCGC	0.637		NaN											0	0	0	0.006122	0	18	46									
AP1G2	8906	broad.mit.edu	37	14	24036487	24036487	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24036487C>T	uc001wkl.2	-	2	374	c.37G>A	c.(37-39)GAA>AAA	p.E13K	AP1G2_uc001wkj.2_5'UTR|AP1G2_uc001wkk.3_5'UTR|AP1G2_uc001wkn.2_5'UTR|uc001wko.1_RNA|AP1G2_uc001wkp.1_5'Flank|AP1G2_uc010tnp.1_Missense_Mutation_p.E13K|AP1G2_uc010aks.2_5'UTR|AP1G2_uc010akt.2_5'UTR|AP1G2_uc010tnq.1_RNA	NM_003917	NP_003908	O75843	AP1G2_HUMAN	adaptor-related protein complex 1, gamma 2	13					interspecies interaction between organisms|intracellular protein transport|vesicle-mediated transport	AP-1 adaptor complex|endosome membrane	protein binding|protein transporter activity			ovary(1)	1	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00672)		CGAATCTCTTCGATGAGGTCC	0.637		NaN									OREG0022606	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001168	0	5	14									
LRRC16B	90668	broad.mit.edu	37	14	24528595	24528595	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24528595G>A	uc001wlj.2	+	21	1900	c.1743G>A	c.(1741-1743)ATG>ATA	p.M581I	LRRC16B_uc001wlk.2_5'Flank	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	581										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		GCAATGGCATGGAGGACATCG	0.642		NaN											0	0	0	0.00308	0	7	10									
LRRC16B	90668	broad.mit.edu	37	14	24532014	24532014	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24532014G>A	uc001wlj.2	+	29	2822	c.2665G>A	c.(2665-2667)GAC>AAC	p.D889N	LRRC16B_uc001wlk.2_5'UTR	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	889										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		CCGGAACCATGACCATGAGGA	0.627		NaN											0	0	0	0.004482	0	7	39									
RNF31	55072	broad.mit.edu	37	14	24617580	24617580	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24617580G>A	uc001wmn.1	+	3	702	c.453G>A	c.(451-453)CTG>CTA	p.L151L	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_5'UTR|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_5'UTR|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	151	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CAGTCACACTGGAAGTACTGC	0.557		NaN											0	0	0	0.004007	0	14	16									
REC8	9985	broad.mit.edu	37	14	24641766	24641766	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24641766T>A	uc001wmr.2	+	2	432	c.5T>A	c.(4-6)TTC>TAC	p.F2Y	REC8_uc001wms.2_Missense_Mutation_p.F2Y	NM_005132	NP_005123	O95072	REC8_HUMAN	REC8 homolog	2					mitotic metaphase/anaphase transition|mitotic prometaphase|reciprocal meiotic recombination|sister chromatid cohesion	nucleoplasm					0				GBM - Glioblastoma multiforme(265;0.00839)		GGGACAATGTTCTACTATCCC	0.592		NaN											0	0	0	0.010729	0	9	7									
IPO4	79711	broad.mit.edu	37	14	24656644	24656644	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24656644G>C	uc001wmv.1	-	6	681	c.550C>G	c.(550-552)CTG>GTG	p.L184V	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_Missense_Mutation_p.L48V|IPO4_uc001wmy.1_Missense_Mutation_p.L48V|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.L184V	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	184					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		ATGGTGGTCAGAGTGCGCAGG	0.577		NaN											0	0	0	0.006122	0	16	64									
IPO4	79711	broad.mit.edu	37	14	24656660	24656660	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24656660G>C	uc001wmv.1	-	6	665	c.534C>G	c.(532-534)TTC>TTG	p.F178L	IPO4_uc001wmt.1_5'Flank|IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_Missense_Mutation_p.F42L|IPO4_uc001wmy.1_Missense_Mutation_p.F42L|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.F178L	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	178					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		GCAGGGAGTAGAAGAGCAGCC	0.592		NaN											0	0	0	0.004007	0	16	64									
IPO4	79711	broad.mit.edu	37	14	24656970	24656970	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24656970G>T	uc001wmv.1	-	5	442	c.311C>A	c.(310-312)TCA>TAA	p.S104*	IPO4_uc001wmu.2_5'UTR|IPO4_uc001wmx.1_5'UTR|IPO4_uc001wmy.1_5'UTR|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Nonsense_Mutation_p.S104*	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	104					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		AATGGTGGCTGAGAGCTGGGC	0.572		NaN											1	0	3.27435e-08	0.00245	3.38028e-08	14	27									
TGM1	7051	broad.mit.edu	37	14	24731453	24731453	+	Missense_Mutation	SNP	G	G	A	rs145197904	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24731453G>A	uc001wod.2	-	2	230	c.106C>T	c.(106-108)CGC>TGC	p.R36C	TGM1_uc010tog.1_5'UTR	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	36	Membrane anchorage region.				cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	CCTCCTCTGCGAGAGCGTCCG	0.647		NaN											0	0	0	0.008291	0	9	32									
C14orf21	161424	broad.mit.edu	37	14	24772312	24772312	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24772312C>T	uc001wol.1	+	6	1239	c.1176C>T	c.(1174-1176)GTC>GTT	p.V392V	C14orf21_uc001wom.1_5'UTR	NM_174913	NP_777573	Q86U38	CN021_HUMAN	hypothetical protein LOC161424	392							RNA binding			breast(2)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(265;0.0185)		TGAGCCCTGTCTTGGAAGCTG	0.478		NaN											0	0	0	0.012319	0	21	51									
NYNRIN	57523	broad.mit.edu	37	14	24883866	24883866	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24883866G>A	uc001wpf.3	+	9	3229	c.2911G>A	c.(2911-2913)GTC>ATC	p.V971I		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	971					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						CTCAGCCAGTGTCACTGAGCT	0.557		NaN											0	0	0	0.013537	0	9	16									
NYNRIN	57523	broad.mit.edu	37	14	24884334	24884334	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:24884334G>A	uc001wpf.3	+	9	3697	c.3379G>A	c.(3379-3381)GAC>AAC	p.D1127N		NM_025081	NP_079357	Q9P2P1	NYNRI_HUMAN	hypothetical protein LOC57523	1127					DNA integration	integral to membrane	DNA binding			ovary(2)|central_nervous_system(1)	3						GCAGAAGCCTGACTGGCAGTG	0.622		NaN											0	0	0	0.010729	0	12	14									
NOVA1	4857	broad.mit.edu	37	14	27064680	27064680	+	Silent	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:27064680A>G	uc001wpy.2	-	2	534	c.216T>C	c.(214-216)ATT>ATC	p.I72I	NOVA1_uc001wpz.2_Silent_p.I72I|NOVA1_uc001wqa.2_5'UTR|NOVA1_uc001wqb.2_Silent_p.I72I	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	72	KH 1.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		GCAACTGAACAATTGTCTGTC	0.403		NaN											0	0	0	0.012319	0	22	103									
HECTD1	25831	broad.mit.edu	37	14	31602842	31602842	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:31602842C>G	uc001wrc.1	-	23	4107	c.3618G>C	c.(3616-3618)GAG>GAC	p.E1206D	HECTD1_uc001wrd.1_Missense_Mutation_p.E721D	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1206					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ACCCTTGTTTCTCATCCTTTG	0.363		NaN											0	0	0	0.00245	0	15	51									
FOXA1	3169	broad.mit.edu	37	14	38060825	38060825	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:38060825C>T	uc001wuf.2	-	2	1476	c.1164G>A	c.(1162-1164)CTG>CTA	p.L388L	FOXA1_uc010tpz.1_Silent_p.L355L	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	388					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		GGTCCCCTTTCAGGTGCAGCT	0.637		NaN											0	0	0	0.004672	0	3	9									
LRFN5	145581	broad.mit.edu	37	14	42356993	42356993	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:42356993G>C	uc001wvm.2	+	3	2363	c.1165G>C	c.(1165-1167)GAG>CAG	p.E389Q	LRFN5_uc010ana.2_Missense_Mutation_p.E389Q	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	389	Extracellular (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CCATATCCATGAGCCTGATCC	0.378		NaN								HNSCC(30;0.082)			0	0	0	0.008871	0	21	53									
FAM179B	23116	broad.mit.edu	37	14	45468596	45468596	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:45468596C>G	uc001wvv.2	+	3	2443	c.2234C>G	c.(2233-2235)TCT>TGT	p.S745C	FAM179B_uc001wvw.2_Missense_Mutation_p.S745C|FAM179B_uc010anc.2_RNA|FAM179B_uc001wvu.2_Missense_Mutation_p.S745C	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	745							binding			skin(2)|upper_aerodigestive_tract(1)	3						ACAAATCTTTCTGGGAAATGT	0.353		NaN											0	0	0	0.00245	0	13	102									
FANCM	57697	broad.mit.edu	37	14	45605471	45605471	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:45605471G>A	uc001wwd.3	+	1	336	c.237G>A	c.(235-237)GCG>GCA	p.A79A	FANCM_uc001wwc.2_Silent_p.A79A|FANCM_uc010anf.2_Silent_p.A79A|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	79					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						GCACCTCCGCGGGCGCCCTGT	0.597		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.006214	0	9	37									
KLHDC2	23588	broad.mit.edu	37	14	50238388	50238388	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:50238388G>A	uc001wwx.2	+	2	630	c.230G>A	c.(229-231)AGA>AAA	p.R77K	SDCCAG1_uc010anj.1_Intron|KLHDC2_uc001wwy.2_Missense_Mutation_p.R77K|KLHDC2_uc010anp.2_Missense_Mutation_p.R77K	NM_014315	NP_055130	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	77	Kelch 1.					nucleus	protein binding			ovary(1)	1	all_epithelial(31;0.000959)|Breast(41;0.0117)					GAGACTGGAAGATGGTAAATG	0.229		NaN											0	0	0	0.006122	0	19	54									
TXNDC16	57544	broad.mit.edu	37	14	52936858	52936858	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:52936858C>T	uc001wzs.2	-	16	1964	c.1515G>A	c.(1513-1515)TCG>TCA	p.S505S	TXNDC16_uc010tqu.1_Silent_p.S500S|TXNDC16_uc010aoe.2_RNA	NM_020784	NP_065835	Q9P2K2	TXD16_HUMAN	thioredoxin domain containing 16 isoform 1	505					cell redox homeostasis	extracellular region					0	Breast(41;0.0716)					CTTCTTGGATCGATGTTATAT	0.289		NaN											0	0	0	0.013537	0	13	83									
DLGAP5	9787	broad.mit.edu	37	14	55642735	55642735	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:55642735C>T	uc001xbs.2	-	9	1268	c.1051G>A	c.(1051-1053)GAT>AAT	p.D351N	DLGAP5_uc001xbt.2_Missense_Mutation_p.D351N	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	351					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						TGAGACTCATCACTAAAAACA	0.313		NaN											0	0	0	0.006122	0	19	60									
SLC35F4	341880	broad.mit.edu	37	14	58047974	58047974	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:58047974C>A	uc001xdb.1	-	4	873	c.873G>T	c.(871-873)TTG>TTT	p.L291F	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.L132F	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TCCATGACAGCAAGAAGACAA	0.443		NaN											1	0	0.000274275	0.004482	0.000279426	8	20									
MNAT1	4331	broad.mit.edu	37	14	61285476	61285476	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:61285476C>T	uc001xfd.2	+	6	709	c.598C>T	c.(598-600)CAG>TAG	p.Q200*	MNAT1_uc001xfe.2_Intron	NM_002431	NP_002422	P51948	MAT1_HUMAN	menage a trois 1 (CAK assembly factor)	200				Missing (in Ref. 3; AAB05248).	cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein complex assembly|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cytoplasm|holo TFIIH complex	protein N-terminus binding|zinc ion binding			ovary(1)|lung(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.0174)		GCTTTTGGCTCAGCATAAAGA	0.368		NaN						Direct_reversal_of_damage|NER					0	0	0	0.010504	0	21	66									
SYNE2	23224	broad.mit.edu	37	14	64608747	64608747	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64608747G>A	uc001xgm.2	+	82	15477	c.15247G>A	c.(15247-15249)GAC>AAC	p.D5083N	SYNE2_uc001xgl.2_Missense_Mutation_p.D5083N|SYNE2_uc010apy.2_Missense_Mutation_p.D1468N|SYNE2_uc001xgn.2_Missense_Mutation_p.D45N|SYNE2_uc001xgo.2_RNA	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5083	Spectrin 2.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTCAGATGAAGACTCCGTGCA	0.383		NaN											0	0	0	0.010729	0	12	41									
SYNE2	23224	broad.mit.edu	37	14	64680937	64680937	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64680937C>T	uc001xgm.2	+	106	19312	c.19082C>T	c.(19081-19083)TCT>TTT	p.S6361F	SYNE2_uc001xgl.2_Missense_Mutation_p.S6361F|SYNE2_uc010apy.2_Missense_Mutation_p.S2746F|SYNE2_uc001xgn.2_Missense_Mutation_p.S1323F|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.S331F|SYNE2_uc001xgq.2_Missense_Mutation_p.S726F|SYNE2_uc001xgr.2_Missense_Mutation_p.S144F|SYNE2_uc010tsi.1_5'UTR|SYNE2_uc001xgs.2_5'UTR|SYNE2_uc001xgt.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6361	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAGGAGGCCTCTGAGAATGAA	0.468		NaN											0	0	0	0.013114	0	48	51									
SYNE2	23224	broad.mit.edu	37	14	64685228	64685228	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64685228C>T	uc001xgm.2	+	108	19816	c.19586C>T	c.(19585-19587)TCA>TTA	p.S6529L	SYNE2_uc001xgl.2_Missense_Mutation_p.S6552L|SYNE2_uc010apy.2_Missense_Mutation_p.S2914L|SYNE2_uc001xgn.2_Missense_Mutation_p.S1491L|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.S499L|SYNE2_uc001xgq.2_Missense_Mutation_p.S894L|SYNE2_uc001xgr.2_Missense_Mutation_p.S312L|SYNE2_uc010tsi.1_Missense_Mutation_p.S186L|SYNE2_uc001xgs.2_Missense_Mutation_p.S186L|SYNE2_uc001xgt.2_Missense_Mutation_p.S60L	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6529	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		GAGCAGCAGTCAGGTACTGCC	0.512		NaN											0	0	0	0.000602	0	5	19									
MTHFD1	4522	broad.mit.edu	37	14	64909033	64909033	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64909033C>G	uc001xhb.2	+	21	2436	c.2049C>G	c.(2047-2049)ATC>ATG	p.I683M	MTHFD1_uc010aqf.2_Missense_Mutation_p.I739M	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	683	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TTTTTAACATCAAATGCCGGT	0.527		NaN											0	0	0	0.010771	0	45	74									
ZBTB1	22890	broad.mit.edu	37	14	64989728	64989728	+	Missense_Mutation	SNP	T	T	G	rs142978553	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64989728T>G	uc001xhh.3	+	4	1937	c.1506T>G	c.(1504-1506)GAT>GAG	p.D502E	ZBTB1_uc010aqg.2_Missense_Mutation_p.D502E|ZBTB1_uc001xhi.2_Missense_Mutation_p.D502E	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		AAATAAGAGATATGTTTGTTG	0.398		NaN											0	0	0	0.004289	0	38	97									
ZBTB1	22890	broad.mit.edu	37	14	64990098	64990098	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:64990098G>C	uc001xhh.3	+	4	2307	c.1876G>C	c.(1876-1878)GAT>CAT	p.D626H	ZBTB1_uc010aqg.2_Missense_Mutation_p.D626H|ZBTB1_uc001xhi.2_Missense_Mutation_p.D626H	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	626	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		ACTGCACAATGATATGCACAA	0.388		NaN											0	0	0	0.01441	0	48	54									
HSPA2	3306	broad.mit.edu	37	14	65009223	65009223	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:65009223C>T	uc001xhj.2	+	2	1732	c.1656C>T	c.(1654-1656)ATC>ATT	p.I552I	HSPA2_uc001xhk.3_Silent_p.I552I	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	552					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CCTACAACATCAAGCAGACGG	0.552		NaN											0	0	0	0.00333	0	25	51									
ARG2	384	broad.mit.edu	37	14	68114822	68114822	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:68114822C>T	uc001xjs.2	+	7	897	c.781C>T	c.(781-783)CCA>TCA	p.P261S		NM_001172	NP_001163	P78540	ARGI2_HUMAN	arginase 2 precursor	261					arginine metabolic process|nitric oxide biosynthetic process|urea cycle	mitochondrial matrix	arginase activity|metal ion binding				0				all cancers(60;0.000582)|OV - Ovarian serous cystadenocarcinoma(108;0.00392)|BRCA - Breast invasive adenocarcinoma(234;0.00928)	L-Arginine(DB00125)|L-Ornithine(DB00129)	TACACTGGCTCCAGCCACAGG	0.388		NaN											0	0	0	0.00245	0	14	37									
PCNX	22990	broad.mit.edu	37	14	71575342	71575342	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:71575342C>T	uc001xmo.2	+	34	6769	c.6323C>T	c.(6322-6324)TCT>TTT	p.S2108F	PCNX_uc010are.1_Missense_Mutation_p.S1997F|PCNX_uc010arf.1_Missense_Mutation_p.S896F|PCNX_uc001xmp.2_Missense_Mutation_p.S192F	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	2108	Ser-rich.					integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AGCTCTCACTCTGTGCAGTCG	0.532		NaN											0	0	0	0.012319	0	21	30									
SIPA1L1	26037	broad.mit.edu	37	14	72196839	72196839	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:72196839G>A	uc001xms.2	+	18	5093	c.4745G>A	c.(4744-4746)AGA>AAA	p.R1582K	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R1561K|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R1561K|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R1582K|SIPA1L1_uc010ttm.1_Missense_Mutation_p.R1036K|SIPA1L1_uc001xmw.2_Missense_Mutation_p.R347K	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1582					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GCCTTGCACAGAACACTGTCG	0.547		NaN											0	0	0	0.010504	0	19	44									
RBM25	58517	broad.mit.edu	37	14	73577788	73577788	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:73577788A>T	uc001xno.2	+	15	2150	c.1942A>T	c.(1942-1944)ATT>TTT	p.I648F	RBM25_uc010ttu.1_Missense_Mutation_p.I648F|RBM25_uc001xnp.2_Missense_Mutation_p.I443F	NM_021239	NP_067062	P49756	RBM25_HUMAN	RNA binding motif protein 25	648					apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		TGGTATTATTATTCCTCATGA	0.468		NaN											0	0	0	0.013537	0	11	42									
TTLL5	23093	broad.mit.edu	37	14	76238194	76238194	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:76238194G>C	uc001xrx.2	+	21	2338	c.2133G>C	c.(2131-2133)CAG>CAC	p.Q711H	TTLL5_uc010ask.1_Missense_Mutation_p.Q725H|TTLL5_uc001xrz.2_Missense_Mutation_p.Q286H|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	711					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		AGGATGAACAGATGGTAAGGC	0.328		NaN											0	0	0	0.005524	0	37	53									
ZC3H14	79882	broad.mit.edu	37	14	89039256	89039256	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:89039256G>C	uc001xww.2	+	6	991	c.766G>C	c.(766-768)GAA>CAA	p.E256Q	ZC3H14_uc010twd.1_Missense_Mutation_p.E256Q|ZC3H14_uc010twe.1_Missense_Mutation_p.E256Q|ZC3H14_uc001xwx.2_Missense_Mutation_p.E256Q|ZC3H14_uc010twf.1_Missense_Mutation_p.E101Q|ZC3H14_uc001xwy.2_Missense_Mutation_p.E222Q|ZC3H14_uc010twg.1_Missense_Mutation_p.E101Q|ZC3H14_uc001xxa.2_5'Flank	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	256						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						TTGGGTATATGAAACAGGACG	0.408		NaN											0	0	0	0.004289	0	39	102									
TTC7B	145567	broad.mit.edu	37	14	91196427	91196427	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:91196427G>A	uc001xyp.2	-	5	812	c.690C>T	c.(688-690)TTC>TTT	p.F230F		NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	230	TPR 2.						binding			ovary(2)	2		Melanoma(154;0.222)				ACCCATTTTTGAAATAGAGGA	0.388		NaN											0	0	0	0.01441	0	51	127									
CCDC88C	440193	broad.mit.edu	37	14	91791126	91791126	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:91791126C>T	uc010aty.2	-	12	1438	c.1339G>A	c.(1339-1341)GAC>AAC	p.D447N		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	447					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				TACCTACCGTCTGACAAGTCT	0.602		NaN											0	0	0	0.004482	0	9	20									
CCDC88C	440193	broad.mit.edu	37	14	91791156	91791156	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:91791156C>G	uc010aty.2	-	12	1408	c.1309G>C	c.(1309-1311)GAG>CAG	p.E437Q		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	437					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				GACAGCTGCTCCAGCTCCCAG	0.587		NaN											0	0	0	0.013537	0	11	36									
CATSPERB	79820	broad.mit.edu	37	14	92084066	92084066	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:92084066C>T	uc001xzs.1	-	20	2415	c.2275G>A	c.(2275-2277)GAA>AAA	p.E759K	CATSPERB_uc010aub.1_Missense_Mutation_p.E281K	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	759					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				AGTGGTATTTCAAGCATTCGA	0.313		NaN											0	0	0	0.009535	0	28	33									
OTUB2	78990	broad.mit.edu	37	14	94512231	94512231	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:94512231C>T	uc001yci.2	+	6	828	c.668C>T	c.(667-669)TCC>TTC	p.S223F		NM_023112	NP_075601	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2	223	OTU.				cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity				0		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		TATAAAACATCCCACTACAAC	0.498		NaN											0	0	0	0.004482	0	8	19									
VRK1	7443	broad.mit.edu	37	14	97313665	97313665	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:97313665G>A	uc001yft.2	+	5	464	c.358G>A	c.(358-360)GAC>AAC	p.D120N		NM_003384	NP_003375	Q99986	VRK1_HUMAN	vaccinia related kinase 1	120	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|stomach(1)	2		Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.234)		TGGTCTACATGACAAAAATGG	0.348		NaN											0	0	0	0.001855	0	13	36									
CYP46A1	10858	broad.mit.edu	37	14	100192565	100192565	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:100192565G>A	uc001ygo.2	+	14	1304	c.1304G>A	c.(1303-1305)CGC>CAC	p.R435H	CYP46A1_uc001ygp.2_Missense_Mutation_p.R272H	NM_006668	NP_006659	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46	435					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity				0		Melanoma(154;0.0866)|all_epithelial(191;0.179)				CTGGGCCACCGCTCCTGCATC	0.642		NaN											0	0	0	0.00245	0	15	31									
BEGAIN	57596	broad.mit.edu	37	14	101012852	101012852	+	Silent	SNP	C	C	G	rs150444261		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:101012852C>G	uc010txa.1	-	2	308	c.162G>C	c.(160-162)ACG>ACC	p.T54T	BEGAIN_uc001yhp.2_5'UTR|BEGAIN_uc001yhq.2_Silent_p.T54T	NM_001159531	NP_001153003	Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	54						cytoplasm|membrane	protein binding				0		Melanoma(154;0.212)				GCAGCTTCTCCGTGACCTTCT	0.373		NaN											0	0	0	0.001168	0	4	7									
DYNC1H1	1778	broad.mit.edu	37	14	102510791	102510791	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:102510791G>A	uc001yks.2	+	71	13029	c.12865G>A	c.(12865-12867)GAC>AAC	p.D4289N		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4289					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						ATGCAAGGTCGACGGACATAA	0.527		NaN											0	0	0	0.008291	0	11	28									
TECPR2	9895	broad.mit.edu	37	14	102898163	102898163	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:102898163C>T	uc001ylw.1	+	8	1263	c.1115C>T	c.(1114-1116)TCA>TTA	p.S372L	TECPR2_uc010awl.2_Missense_Mutation_p.S372L|TECPR2_uc010txx.1_Intron	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	372							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						TCTGGATGCTCAGAGCGTGTC	0.552		NaN											0	0	0	0.00632	0	29	87									
TNFAIP2	7127	broad.mit.edu	37	14	103593907	103593907	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:103593907C>T	uc001ymm.1	+	2	932	c.801C>T	c.(799-801)TTC>TTT	p.F267F	TNFAIP2_uc010awo.1_Intron|TNFAIP2_uc010txz.1_5'UTR	NM_006291	NP_006282	Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	267					angiogenesis|cell differentiation	extracellular space				central_nervous_system(1)	1		Melanoma(154;0.155)	Epithelial(46;0.191)			TGGCGCAGTTCGAGCTGTGCG	0.701		NaN											0	0	0	0.004672	0	3	3									
MARK3	4140	broad.mit.edu	37	14	103969477	103969477	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:103969477G>T	uc001ymz.3	+	18	2841	c.2175G>T	c.(2173-2175)CTG>CTT	p.L725L	MARK3_uc001ymx.3_Silent_p.L716L|MARK3_uc001ymw.3_Silent_p.L701L|MARK3_uc001yna.3_Silent_p.L685L|MARK3_uc001ymy.3_Silent_p.L631L|MARK3_uc010awp.2_Silent_p.L724L|MARK3_uc010tyb.1_Silent_p.L520L|MARK3_uc010awq.2_Silent_p.L298L|MARK3_uc001ynd.2_Silent_p.L133L	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	725	KA1.						ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			GACTGTCTCTGAACGGGGTCC	0.512		NaN											1	0	3.52763e-06	0.00499	3.61253e-06	15	36									
ASPG	374569	broad.mit.edu	37	14	104571063	104571063	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:104571063C>T	uc001yoq.1	+	9	1101	c.1041C>T	c.(1039-1041)GTC>GTT	p.V347V	ASPG_uc001yoo.1_Silent_p.V375V|ASPG_uc001yop.1_Silent_p.V347V|ASPG_uc001yor.1_Silent_p.V347V	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	347	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						GCCTGGATGTCAGGAAGGAGG	0.657		NaN											0	0	0	0.013537	0	10	6									
AHNAK2	113146	broad.mit.edu	37	14	105408667	105408667	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:105408667C>T	uc010axc.1	-	7	13241	c.13121G>A	c.(13120-13122)GGA>GAA	p.G4374E	AHNAK2_uc001ypx.2_Missense_Mutation_p.G4274E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4374						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GAGGCCGGCTCCCTCATGCAC	0.587		NaN											0	0	0	0.01441	0	87	63									
JAG2	3714	broad.mit.edu	37	14	105618508	105618508	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:105618508G>A	uc001yqg.2	-	6	1313	c.909C>T	c.(907-909)CTC>CTT	p.L303L	JAG2_uc001yqf.2_5'Flank|JAG2_uc001yqh.2_Silent_p.L303L	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	303	Extracellular (Potential).|EGF-like 2; atypical.				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		CTTTGTCACAGAGCAGGCCGC	0.637		NaN											0	0	0	0.004289	0	33	34									
NIPA2	81614	broad.mit.edu	37	15	23012428	23012428	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:23012428G>A	uc001yux.2	-	7	912	c.299C>T	c.(298-300)TCT>TTT	p.S100F	NIPA2_uc001yuy.2_Missense_Mutation_p.S100F|NIPA2_uc001yuz.2_Missense_Mutation_p.S100F|NIPA2_uc001yva.2_Missense_Mutation_p.S81F|NIPA2_uc001yvb.2_Missense_Mutation_p.S100F|NIPA2_uc010ayb.2_Missense_Mutation_p.S81F	NM_030922	NP_112184	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome	100	Cytoplasmic (Potential).					early endosome|integral to membrane|plasma membrane				haematopoietic_and_lymphoid_tissue(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		AAAGTATGAAGAAAGAATGGC	0.318		NaN											0	0	0	0.01441	0	59	101									
UBE3A	7337	broad.mit.edu	37	15	25584354	25584354	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:25584354G>A	uc001zaq.2	-	11	2558	c.2558C>T	c.(2557-2559)TCA>TTA	p.S853L	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.S830L|UBE3A_uc001zas.2_Missense_Mutation_p.S850L|UBE3A_uc001zat.2_Missense_Mutation_p.S830L	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	853	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TTCTTTGCTTGAGTATTCCGG	0.313		NaN											0	0	0	0.00278	0	22	63									
GABRA5	2558	broad.mit.edu	37	15	27188493	27188493	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:27188493G>C	uc001zbd.1	+	11	1348	c.1009G>C	c.(1009-1011)GAG>CAG	p.E337Q	GABRA5_uc001zbe.1_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	337	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGCGCTGATAGAGTTTGCCAC	0.542		NaN											0	0	0	0.001168	0	6	9									
RYR3	6263	broad.mit.edu	37	15	33941338	33941338	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:33941338G>T	uc001zhi.2	+	31	4114	c.4044G>T	c.(4042-4044)GTG>GTT	p.V1348V	RYR3_uc010bar.2_Silent_p.V1348V	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1348	4 X approximate repeats.|B30.2/SPRY 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCGGATGGGTGACTCCAGACT	0.532		NaN											1	0	3.73988e-18	0.00632	3.95109e-18	29	118									
PGBD4	161779	broad.mit.edu	37	15	34395021	34395021	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:34395021G>A	uc001zho.2	+	1	748	c.289G>A	c.(289-291)GAT>AAT	p.D97N	C15orf24_uc001zhm.2_5'Flank|C15orf24_uc001zhn.2_5'Flank	NM_152595	NP_689808	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	97											0		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		CAGAAAAGTCGATGTCAGTGA	0.433		NaN											0	0	0	0.013726	0	36	33									
AQR	9716	broad.mit.edu	37	15	35189812	35189812	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:35189812C>T	uc001ziv.2	-	21	2519	c.2338G>A	c.(2338-2340)GAG>AAG	p.E780K		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	780						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		ACATGGGGCTCAACAATTAAG	0.368		NaN											0	0	0	0.012319	0	22	91									
AQR	9716	broad.mit.edu	37	15	35230975	35230975	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:35230975C>T	uc001ziv.2	-	9	862	c.681G>A	c.(679-681)CAG>CAA	p.Q227Q		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	227						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		AGATAAACTTCTGGATGAGTT	0.338		NaN											0	0	0	0.004007	0	17	119									
C15orf54	400360	broad.mit.edu	37	15	39544580	39544580	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:39544580C>G	uc001zkg.2	+	2	612	c.244C>G	c.(244-246)CAA>GAA	p.Q82E		NM_207445	NP_997328	Q8N8G6	CO054_HUMAN	hypothetical protein LOC400360	82											0		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		GACATCACATCAAATCATCCA	0.448		NaN											0	0	0	0.005524	0	40	150									
BMF	90427	broad.mit.edu	37	15	40396422	40396422	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:40396422G>A	uc001zkv.2	-	3	498	c.412C>T	c.(412-414)CAG>TAG	p.Q138*	BMF_uc001zkt.2_Intron|BMF_uc001zku.2_Intron|BMF_uc001zkw.2_Nonsense_Mutation_p.Q138*	NM_033503	NP_277038	Q96LC9	BMF_HUMAN	Bcl2 modifying factor isoform bmf-1	138	BH3.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			ovary(1)	1		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		GCAATGCACTGAAGCTTTCGG	0.612		NaN											0	0	0	0.01441	0	84	90									
BUB1B	701	broad.mit.edu	37	15	40505608	40505608	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:40505608G>A	uc001zkx.3	+	20	2823	c.2611G>A	c.(2611-2613)GAG>AAG	p.E871K		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	871	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		GACAATAGTGGAGATGCTACA	0.378		NaN	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.005443	0	28	74									
CHST14	113189	broad.mit.edu	37	15	40763862	40763862	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:40763862C>G	uc001zlw.2	+	1	650	c.450C>G	c.(448-450)CTC>CTG	p.L150L		NM_130468	NP_569735	Q8NCH0	CHSTE_HUMAN	dermatan 4 sulfotransferase 1	150	Lumenal (Potential).				carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding				0		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		ACCGCTTCCTCTACTGCTACG	0.662		NaN											0	0	0	0.00499	0	17	36									
CHST14	113189	broad.mit.edu	37	15	40764104	40764104	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:40764104G>A	uc001zlw.2	+	1	892	c.692G>A	c.(691-693)CGA>CAA	p.R231Q		NM_130468	NP_569735	Q8NCH0	CHSTE_HUMAN	dermatan 4 sulfotransferase 1	231	Lumenal (Potential).				carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding				0		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		GGCGAGATCCGAGAGTACCAG	0.597		NaN											0	0	0	0.01441	0	42	95									
TYRO3	7301	broad.mit.edu	37	15	41865267	41865267	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:41865267C>T	uc001zof.1	+	16	2167	c.1943C>T	c.(1942-1944)TCT>TTT	p.S648F		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	648	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TACCTGAGCTCTCGGAACTTC	0.572		NaN											0	0	0	0.011902	0	43	37									
UBR1	197131	broad.mit.edu	37	15	43307928	43307928	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:43307928G>A	uc001zqq.2	-	29	3233	c.3167C>T	c.(3166-3168)TCA>TTA	p.S1056L	UBR1_uc010udk.1_Missense_Mutation_p.S1056L	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1056					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AGGCATTTCTGATGTATTGTC	0.343		NaN											0	0	0	0.01441	0	57	189									
TMEM62	80021	broad.mit.edu	37	15	43476562	43476562	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:43476562G>A	uc001zqr.2	+	14	1989	c.1710G>A	c.(1708-1710)TTG>TTA	p.L570L	TMEM62_uc010bda.2_Silent_p.L405L|TMEM62_uc001zqt.2_Silent_p.L139L|CCNDBP1_uc001zqu.2_5'Flank|CCNDBP1_uc001zqv.2_5'Flank|CCNDBP1_uc010bdc.2_5'Flank|CCNDBP1_uc010bdb.2_5'Flank|CCNDBP1_uc010udl.1_5'Flank|CCNDBP1_uc001zqw.2_5'Flank|CCNDBP1_uc001zqx.2_5'Flank|CCNDBP1_uc010bdd.2_5'Flank|CCNDBP1_uc001zqy.2_5'Flank	NM_024956	NP_079232	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	570						integral to membrane				ovary(1)|breast(1)	2		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		GAAAATACTTGAAAATTATGC	0.418		NaN											0	0	0	0.01441	0	146	156									
EPB42	2038	broad.mit.edu	37	15	43489643	43489643	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:43489643C>T	uc001zra.3	-	13	2233	c.1933G>A	c.(1933-1935)GAA>AAA	p.E645K	EPB42_uc001zqz.3_Missense_Mutation_p.E312K|EPB42_uc010bde.2_Silent_p.*436*|EPB42_uc001zrb.3_Missense_Mutation_p.E675K|EPB42_uc010udm.1_Missense_Mutation_p.E567K	NM_001114134	NP_001107606	P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2 isoform 2	645					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			ovary(2)	2		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		ATGGTGTTTTCAGGCCACACT	0.498		NaN											0	0	0	0.013726	0	32	41									
DUOX2	50506	broad.mit.edu	37	15	45386349	45386349	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:45386349C>T	uc010bea.2	-	34	4849	c.4646G>A	c.(4645-4647)TGA>TAA	p.*1549*	DUOX2_uc001zun.2_Silent_p.*1549*	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1549					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		AGGACAGGCTCAGAAGTTCTC	0.557		NaN											0	0	0	0.010729	0	10	43									
DUOX1	53905	broad.mit.edu	37	15	45445633	45445633	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:45445633C>T	uc001zus.1	+	27	3826	c.3480C>T	c.(3478-3480)CTC>CTT	p.L1160L	DUOX1_uc001zut.1_Silent_p.L1160L|DUOX1_uc010bee.1_Silent_p.L540L	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	1160	Helical; (Potential).|Interaction with TXNDC11 (By similarity).|Ferric oxidoreductase.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TCAGCCCCCTCAGCGTCCTCT	0.438		NaN											0	0	0	0.009535	0	29	101									
SHF	90525	broad.mit.edu	37	15	45460156	45460156	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:45460156G>C	uc001zuy.2	-	8	1756	c.1261C>G	c.(1261-1263)CGG>GGG	p.R421G	SHF_uc010uen.1_Missense_Mutation_p.R237G|SHF_uc010ueo.1_Missense_Mutation_p.R237G|SHF_uc010uep.1_3'UTR|SHF_uc010ueq.1_Missense_Mutation_p.R197G|SHF_uc010uer.1_3'UTR	NM_138356	NP_612365	Q7M4L6	SHF_HUMAN	Src homology 2 domain containing F	Error:Variant_position_missing_in_B3KTY1_after_alignment										ovary(1)	1		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		TAAAGAGTCCGGATGGCCACA	0.587		NaN									OREG0023104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	12	29									
SHC4	399694	broad.mit.edu	37	15	49176534	49176534	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:49176534C>A	uc001zxb.1	-	4	1180	c.751G>T	c.(751-753)GGC>TGC	p.G251C		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	251	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TTACTTTTGCCAAGGACTGTT	0.318		NaN											1	0	6.72482e-11	0.003163	7.01243e-11	15	50									
LEO1	123169	broad.mit.edu	37	15	52250986	52250986	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:52250986C>G	uc002abo.2	-	6	1214	c.1198G>C	c.(1198-1200)GAT>CAT	p.D400H	LEO1_uc010bfd.2_Intron	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	400					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		ATTTCTTCATCTTCAAATTCA	0.274		NaN											0	0	0	0.014323	0	22	65									
GNB5	10681	broad.mit.edu	37	15	52416747	52416747	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:52416747C>T	uc002abt.1	-	12	1164	c.1099G>A	c.(1099-1101)GAA>AAA	p.E367K	GNB5_uc002abr.1_Missense_Mutation_p.E325K|GNB5_uc002abs.1_Missense_Mutation_p.E255K	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	367	WD 7.					heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		ACGCGGTTTTCATGTCCAAAC	0.498		NaN											0	0	0	0.006122	0	18	56									
TEX9	374618	broad.mit.edu	37	15	56665652	56665652	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:56665652G>C	uc002adp.2	+	3	138	c.133G>C	c.(133-135)GAA>CAA	p.E45Q	TEX9_uc002ado.1_Missense_Mutation_p.E45Q|TEX9_uc010ugl.1_5'UTR|TEX9_uc002adq.1_5'UTR	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	45											0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		TTTAAATGCAGAATTGCAGGC	0.284		NaN											0	0	0	0.00245	0	13	24									
TCF12	6938	broad.mit.edu	37	15	57565345	57565345	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:57565345C>T	uc002aec.2	+	18	2075	c.1791C>T	c.(1789-1791)TTC>TTT	p.F597F	TCF12_uc010ugm.1_Silent_p.F649F|TCF12_uc010ugn.1_Silent_p.F617F|TCF12_uc002aea.2_Silent_p.F621F|TCF12_uc010bfs.2_Silent_p.F18F|TCF12_uc002aeb.2_Silent_p.F621F|TCF12_uc002aed.2_Silent_p.F597F|TCF12_uc002aee.2_Silent_p.F427F|TCF12_uc010bft.2_Silent_p.F451F|TCF12_uc010ugo.1_Silent_p.F361F|TCF12_uc010ugp.1_Silent_p.F254F|TCF12_uc010ugq.1_Silent_p.F231F|TCF12_uc010ugr.1_Silent_p.F210F	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	597	Helix-loop-helix motif.				immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATGAAGCATTCAAAGAGCTTG	0.458		NaN	T	TEC	extraskeletal myxoid chondrosarcoma								0	0	0	0.004007	0	17	57									
ADAM10	102	broad.mit.edu	37	15	58904123	58904123	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:58904123C>T	uc002afd.1	-	12	2023	c.1579G>A	c.(1579-1581)GAT>AAT	p.D527N	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Missense_Mutation_p.D226N|ADAM10_uc002afe.1_Intron|ADAM10_uc002aff.1_Missense_Mutation_p.D64N	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	527	Extracellular (Potential).|Disintegrin.				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		CAGTCTGAATCATCCCGACAC	0.428		NaN											0	0	0	0.00333	0	23	57									
GTF2A2	2958	broad.mit.edu	37	15	59942969	59942969	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:59942969G>A	uc002agg.2	-	3	258	c.76C>T	c.(76-78)CAA>TAA	p.Q26*		NM_004492	NP_004483	P52657	T2AG_HUMAN	general transcription factor IIA, 2, 12kDa	26					interspecies interaction between organisms|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIA complex	protein heterodimerization activity|protein homodimerization activity|TBP-class protein binding|transcription coactivator activity			central_nervous_system(2)	2						GTGATCTGTTGAGACTGAGAA	0.368		NaN											0	0	0	0.004656	0	26	33									
USP3	9960	broad.mit.edu	37	15	63850344	63850344	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:63850344T>G	uc002amf.2	+	6	619	c.490T>G	c.(490-492)TTG>GTG	p.L164V	USP3_uc010uii.1_Intron|USP3_uc002amg.2_Missense_Mutation_p.L79V|USP3_uc002amh.2_Missense_Mutation_p.L142V|USP3_uc010uij.1_Missense_Mutation_p.L120V|USP3_uc010uik.1_Intron|USP3_uc010bgs.2_Missense_Mutation_p.L147V|USP3_uc002ami.2_Translation_Start_Site	NM_006537	NP_006528	Q9Y6I4	UBP3_HUMAN	ubiquitin thiolesterase 3	164					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(80;0.0187)		CCTTCGGAATTTGGGGAACAC	0.428		NaN											0	0	0	0.010818	0	31	30									
HERC1	8925	broad.mit.edu	37	15	64005075	64005075	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64005075C>G	uc002amp.2	-	24	4631	c.4483G>C	c.(4483-4485)GAG>CAG	p.E1495Q	HERC1_uc010uil.1_Missense_Mutation_p.E479Q	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1495					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						AGCCGGCTCTCTGCAGTAAGA	0.398		NaN											0	0	0	0.00308	0	8	19									
HERC1	8925	broad.mit.edu	37	15	64005081	64005081	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64005081T>G	uc002amp.2	-	24	4625	c.4477A>C	c.(4477-4479)ACT>CCT	p.T1493P	HERC1_uc010uil.1_Missense_Mutation_p.T477P	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1493					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						CTCTCTGCAGTAAGACTTTCA	0.383		NaN											0	0	0	0.008291	0	10	13									
HERC1	8925	broad.mit.edu	37	15	64017671	64017671	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64017671G>A	uc002amp.2	-	18	3536	c.3388C>T	c.(3388-3390)CAG>TAG	p.Q1130*	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1130					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TGAGCTGGCTGAGGTAATGGC	0.448		NaN											0	0	0	0.006122	0	14	58									
DAPK2	23604	broad.mit.edu	37	15	64332447	64332447	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64332447G>C	uc002amr.2	-	2	45	c.14C>G	c.(13-15)TCA>TGA	p.S5*	DAPK2_uc010uim.1_RNA|DAPK2_uc010bgu.1_5'UTR	NM_014326	NP_055141	Q9UIK4	DAPK2_HUMAN	death-associated kinase 2	5					apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			stomach(1)|central_nervous_system(1)	2				LUAD - Lung adenocarcinoma(2;0.215)		ACTCCTCATTGAGGCCTGGAA	0.488		NaN											0	0	0	0.007413	0	20	95									
SNX22	79856	broad.mit.edu	37	15	64445458	64445458	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:64445458G>A	uc002anc.1	+	4	338	c.279G>A	c.(277-279)CTG>CTA	p.L93L	SNX22_uc002amz.1_Silent_p.L65L|SNX22_uc002ana.1_3'UTR|SNX22_uc002anb.1_RNA	NM_024798	NP_079074	Q96L94	SNX22_HUMAN	sorting nexin 22	93	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0						TCCTGTACCTGAACCAGGAGG	0.423		NaN											0	0	0	0.011902	0	43	29									
IGDCC3	9543	broad.mit.edu	37	15	65622908	65622908	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:65622908G>A	uc002aos.2	-	10	1985	c.1733C>T	c.(1732-1734)TCC>TTC	p.S578F	IGDCC3_uc002aor.1_5'Flank	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	578	Extracellular (Potential).|Fibronectin type-III 2.									ovary(3)	3						GAGGTTGTAGGAGGAGACGGT	0.667		NaN											0	0	0	0.003954	0	25	36									
C15orf44	81556	broad.mit.edu	37	15	65890802	65890802	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:65890802C>T	uc002apd.2	-	6	942	c.606_splice	c.e6-1	p.G202_splice	C15orf44_uc010uix.1_Splice_Site_p.G238_splice|C15orf44_uc010uiz.1_Splice_Site_p.G166_splice|C15orf44_uc010uja.1_Splice_Site_p.G153_splice|C15orf44_uc010ujb.1_Splice_Site_p.G123_splice|C15orf44_uc002ape.3_Splice_Site_p.G202_splice|C15orf44_uc010uiy.1_Splice_Site_p.G123_splice	NM_030800	NP_110427	Q96SY0	CO044_HUMAN	hypothetical protein LOC81556 isoform 2											ovary(1)	1						TATCAGTTTTCTAGAATATGA	0.378		NaN											0	0	0	0.006214	0	10	35									
SMAD3	4088	broad.mit.edu	37	15	67473685	67473685	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:67473685G>A	uc002aqj.2	+	6	1063	c.765G>A	c.(763-765)ATG>ATA	p.M255I	SMAD3_uc010ujr.1_Missense_Mutation_p.M150I|SMAD3_uc010ujs.1_Missense_Mutation_p.M211I|SMAD3_uc010ujt.1_Missense_Mutation_p.M60I	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	255	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		AGCCATCCATGACTGTGGATG	0.597		NaN											0	0	0	0.004482	0	7	22									
AAGAB	79719	broad.mit.edu	37	15	67495178	67495178	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:67495178G>A	uc002aqk.3	-	10	1034	c.929C>T	c.(928-930)TCA>TTA	p.S310L	AAGAB_uc002aql.2_Missense_Mutation_p.S201L|AAGAB_uc010uju.1_Missense_Mutation_p.S201L	NM_024666	NP_078942	Q6PD74	AAGAB_HUMAN	alpha- and gamma-adaptin-binding protein p34	310					protein transport	cytoplasm					0						TTCATCAGATGAAAGGCCTTC	0.448		NaN											0	0	0	0.004007	0	13	46									
ANP32A	8125	broad.mit.edu	37	15	69080226	69080226	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:69080226C>T	uc002arl.2	-	2	258	c.87G>A	c.(85-87)TCG>TCA	p.S29S		NM_006305	NP_006296	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	29	LRR 1.				intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding				0						TGCCTTCATTCGACCGACTGT	0.502		NaN											0	0	0	0.007835	0	37	112									
NOX5	79400	broad.mit.edu	37	15	69327705	69327705	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:69327705C>T	uc002ars.1	+	6	887	c.867C>T	c.(865-867)CTC>CTT	p.L289L	NOX5_uc002arp.1_Silent_p.L271L|NOX5_uc002arq.1_Silent_p.L243L|NOX5_uc010bid.1_Silent_p.L254L|NOX5_uc002arr.1_Silent_p.L261L|NOX5_uc010bie.1_Silent_p.L89L|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	289	Helical; (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						TGCTGATGCTCAGACGCTGCC	0.612		NaN											0	0	0	0.001984	0	5	16									
KIF23	9493	broad.mit.edu	37	15	69721528	69721528	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:69721528G>A	uc002asb.2	+	10	1165	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	KIF23_uc002asc.2_Missense_Mutation_p.E350K|KIF23_uc010bii.2_Missense_Mutation_p.E240K|KIF23_uc010ukc.1_Missense_Mutation_p.E167K|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	350	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						GACCAGAGCAGAAGGGAACAG	0.368		NaN											0	0	0	0.008291	0	11	4									
MYO9A	4649	broad.mit.edu	37	15	72338155	72338155	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:72338155G>C	uc002atl.3	-	2	1223	c.750C>G	c.(748-750)AAC>AAG	p.N250K	MYO9A_uc010biq.2_Intron|MYO9A_uc002ato.2_Missense_Mutation_p.N250K|MYO9A_uc002atn.1_Missense_Mutation_p.N250K	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	250	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						GAATAAGAAAGTTTGTGCTTT	0.433		NaN											0	0	0	0.012319	0	21	71									
PKM2	5315	broad.mit.edu	37	15	72492911	72492911	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:72492911G>T	uc002atx.1	-	10	1634	c.1393C>A	c.(1393-1395)CTG>ATG	p.L465M	GRAMD2_uc002atq.2_5'Flank|GRAMD2_uc010bis.2_5'Flank|PKM2_uc002atr.1_Translation_Start_Site|PKM2_uc002ats.1_Missense_Mutation_p.L132M|PKM2_uc002att.1_Missense_Mutation_p.L231M|PKM2_uc002atu.1_Missense_Mutation_p.L231M|PKM2_uc010bit.1_Missense_Mutation_p.L470M|PKM2_uc010uki.1_Missense_Mutation_p.L539M|PKM2_uc002atv.1_Missense_Mutation_p.L500M|PKM2_uc002atw.1_Missense_Mutation_p.L465M|PKM2_uc002aty.1_Missense_Mutation_p.L465M|PKM2_uc010ukj.1_Missense_Mutation_p.L450M|PKM2_uc010ukk.1_Missense_Mutation_p.L391M|PKM2_uc010biu.1_Missense_Mutation_p.L486M	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	465	Interaction with POU5F1.				glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	CCACGGTACAGGTGGGCCTGA	0.617		NaN											1	0	1.5842e-08	0.001855	1.63935e-08	14	51									
PKM2	5315	broad.mit.edu	37	15	72499149	72499149	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:72499149C>T	uc002atx.1	-	8	1301	c.1060G>A	c.(1060-1062)GAT>AAT	p.D354N	PKM2_uc002ats.1_Missense_Mutation_p.D21N|PKM2_uc002att.1_Missense_Mutation_p.D120N|PKM2_uc002atu.1_Missense_Mutation_p.D120N|PKM2_uc010bit.1_Missense_Mutation_p.D359N|PKM2_uc010uki.1_Missense_Mutation_p.D428N|PKM2_uc002atv.1_Missense_Mutation_p.D389N|PKM2_uc002atw.1_Missense_Mutation_p.D354N|PKM2_uc002aty.1_Missense_Mutation_p.D354N|PKM2_uc010ukj.1_Missense_Mutation_p.D339N|PKM2_uc010ukk.1_Missense_Mutation_p.D280N|PKM2_uc010biu.1_Missense_Mutation_p.D375N|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	354	Interaction with POU5F1.				glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	TCGGCTCCATCCAGGACTGCA	0.592		NaN											0	0	0	0.007291	0	27	21									
HEXA	3073	broad.mit.edu	37	15	72668266	72668266	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:72668266G>A	uc002aun.3	-	1	255	c.48C>T	c.(46-48)TTC>TTT	p.F16F	CELF6_uc002auk.3_RNA|HEXA_uc010ukn.1_Silent_p.F16F|HEXA_uc002auo.3_5'UTR|HEXA_uc010bix.2_Silent_p.F16F|HEXA_uc010biy.2_5'UTR|HEXA_uc010uko.1_5'UTR|HEXA_uc010biz.1_RNA|C15orf34_uc010ukp.1_5'Flank	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	16					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						CCCGTCCTGCGAACGCTGCCG	0.627		NaN											0	0	0	0.009535	0	28	18									
ISLR	3671	broad.mit.edu	37	15	74468086	74468086	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:74468086C>T	uc002axg.1	+	2	1169	c.887C>T	c.(886-888)CCT>CTT	p.P296L	ISLR_uc002axh.1_Missense_Mutation_p.P296L	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	296	Ig-like.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CCTGGCACCCCTGTGGCCAGC	0.647		NaN											0	0	0	0.004656	0	22	74									
EDC3	80153	broad.mit.edu	37	15	74927761	74927761	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:74927761G>A	uc002ayn.2	-	9	1669	c.1181C>T	c.(1180-1182)TCT>TTT	p.S394F	EDC3_uc002ayo.2_Missense_Mutation_p.S394F|EDC3_uc002aym.2_Missense_Mutation_p.S394F	NM_001142443	NP_001135915	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	394	YjeF N-terminal.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			ovary(1)	1						TTTGAGGCTAGACACTTGTTG	0.532		NaN									OREG0023287	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	34	29									
C15orf17	57184	broad.mit.edu	37	15	75198699	75198699	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:75198699G>A	uc002azh.3	-	2	543	c.222C>T	c.(220-222)CAC>CAT	p.H74H	C15orf17_uc010bkh.2_5'UTR|C15orf17_uc002azg.2_Silent_p.H74H|C15orf17_uc002azf.2_Silent_p.H74H	NM_020447	NP_065180	Q5XKK7	CO017_HUMAN	hypothetical protein LOC57184	74							cytochrome-c oxidase activity				0						CCAGGTCCCGGTGCTTCTCTG	0.642		NaN											0	0	0	0.009096	0	4	14									
PPCDC	60490	broad.mit.edu	37	15	75335823	75335823	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:75335823C>T	uc002azo.2	+	3	290	c.177C>T	c.(175-177)TTC>TTT	p.F59F		NM_021823	NP_068595	Q96CD2	COAC_HUMAN	phosphopantothenoylcysteine decarboxylase	59		FMN.			coenzyme A biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenoylcysteine decarboxylase activity				0						CCAAACATTTCTACAGCCCCC	0.562		NaN									OREG0023296	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	12									
C15orf39	56905	broad.mit.edu	37	15	75499996	75499996	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:75499996C>G	uc002azp.3	+	2	1927	c.1607C>G	c.(1606-1608)TCA>TGA	p.S536*	C15orf39_uc002azq.3_Nonsense_Mutation_p.S536*|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	536											0						GAGCCTGACTCAGCCCCAGCC	0.617		NaN											0	0	0	0.004482	0	6	10									
SIN3A	25942	broad.mit.edu	37	15	75668090	75668090	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:75668090G>T	uc002bai.2	-	20	3766	c.3507C>A	c.(3505-3507)TTC>TTA	p.F1169L	SIN3A_uc002baj.2_Missense_Mutation_p.F1169L|SIN3A_uc010uml.1_Missense_Mutation_p.F1169L	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1169					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						AATTCAGCTTGAATCTACACT	0.483		NaN											1	0	2.05212e-20	0.005524	2.17013e-20	39	102									
SH2D7	646892	broad.mit.edu	37	15	78393321	78393321	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:78393321C>T	uc010blb.1	+	5	726	c.726C>T	c.(724-726)ATC>ATT	p.I242I		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	242											0						GTGACATCATCTATGCAGACC	0.612		NaN											0	0	0	0.007413	0	18	33									
ARNT2	9915	broad.mit.edu	37	15	80883951	80883951	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:80883951C>T	uc002bfr.2	+	18	2127	c.1961C>T	c.(1960-1962)TCG>TTG	p.S654L	ARNT2_uc010unm.1_Missense_Mutation_p.S643L|ARNT2_uc002bfs.2_Missense_Mutation_p.S643L	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	654					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			GGGCGGCCCTCGGAAGTCTGG	0.562		NaN											0	0	0	0.007413	0	19	44									
MEX3B	84206	broad.mit.edu	37	15	82336488	82336488	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:82336488G>A	uc002bgq.1	-	2	1038	c.723C>T	c.(721-723)TTC>TTT	p.F241F		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	241					protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						CGTTGGCGTGGAAGTCGTTCT	0.642		NaN											0	0	0	0.013726	0	31	83									
WDR73	84942	broad.mit.edu	37	15	85186742	85186742	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:85186742G>A	uc002bkw.2	-	8	1112	c.1096C>T	c.(1096-1098)CTG>TTG	p.L366L	WDR73_uc002bkv.2_RNA|WDR73_uc002bkx.2_RNA|uc002bky.1_5'Flank	NM_032856	NP_116245	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	366	WD 3.										0						CACACATGCAGAGAGGCATCA	0.468		NaN											0	0	0	0.004482	0	9	13									
WDR73	84942	broad.mit.edu	37	15	85188819	85188819	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:85188819G>A	uc002bkw.2	-	7	782	c.766C>T	c.(766-768)CGG>TGG	p.R256W	WDR73_uc002bkv.2_RNA|WDR73_uc002bkx.2_RNA|WDR73_uc010upa.1_3'UTR|uc002bky.1_Missense_Mutation_p.R104Q	NM_032856	NP_116245	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	256											0						CAGAGATCCCGGGGGTCAAGA	0.617		NaN											0	0	0	0.001984	0	7	9									
AKAP13	11214	broad.mit.edu	37	15	86076934	86076934	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:86076934C>G	uc002blv.1	+	4	471	c.301C>G	c.(301-303)CAA>GAA	p.Q101E	AKAP13_uc002bls.2_Missense_Mutation_p.Q101E|AKAP13_uc002blt.1_Missense_Mutation_p.Q101E|AKAP13_uc002blu.1_Missense_Mutation_p.Q101E	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	101					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						TGATGCAGCTCAATTCCTAGC	0.493		NaN											0	0	0	0.010504	0	20	57									
AKAP13	11214	broad.mit.edu	37	15	86087153	86087153	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:86087153G>A	uc002blv.1	+	5	799	c.629G>A	c.(628-630)CGA>CAA	p.R210Q	AKAP13_uc002blt.1_Missense_Mutation_p.R210Q|AKAP13_uc002blu.1_Missense_Mutation_p.R210Q	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	210					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GCCTTGGAGCGAGGCTATCAC	0.582		NaN											0	0	0	0.004482	0	9	45									
ISG20	3669	broad.mit.edu	37	15	89182687	89182687	+	Silent	SNP	C	C	T	rs144037981		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:89182687C>T	uc002bmv.1	+	2	383	c.90C>T	c.(88-90)CTC>CTT	p.L30L	ISG20_uc002bmu.1_Intron|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	30					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			GTTGCAGCCTCGTGAACGTCC	0.647		NaN									OREG0023441	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	12	18									
ACAN	176	broad.mit.edu	37	15	89401276	89401276	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:89401276G>A	uc010upo.1	+	12	5834	c.5460G>A	c.(5458-5460)ACG>ACA	p.T1820T	ACAN_uc010upp.1_Silent_p.T1820T|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1820					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTGGTACCACGAGTGGCAGCG	0.522		NaN											0	0	0	0.001168	0	5	26									
ACAN	176	broad.mit.edu	37	15	89402471	89402471	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:89402471G>A	uc010upo.1	+	12	7029	c.6655G>A	c.(6655-6657)GAG>AAG	p.E2219K	ACAN_uc010upp.1_Missense_Mutation_p.E2219K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2219					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CAGCATCCCAGAGTCTGAGTG	0.572		NaN											0	0	0	0.00499	0	16	27									
CRTC3	64784	broad.mit.edu	37	15	91172546	91172546	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:91172546C>T	uc002bpp.2	+	11	1154	c.1048C>T	c.(1048-1050)CCA>TCA	p.P350S	CRTC3_uc002bpo.2_Missense_Mutation_p.P350S	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	350					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			AAATAACCACCCACAGACATC	0.512		NaN	T	MAML2	salivary gland mucoepidermoid								0	0	0	0.00874	0	42	148									
UNC45A	55898	broad.mit.edu	37	15	91488214	91488214	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:91488214C>G	uc002bqg.2	+	9	1460	c.1120C>G	c.(1120-1122)CTC>GTC	p.L374V	UNC45A_uc002bqd.2_Missense_Mutation_p.L359V	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	374					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CGCCTCTATTCTCCTCAGCAA	0.498		NaN											0	0	0	0.010729	0	12	66									
PRC1	9055	broad.mit.edu	37	15	91517833	91517833	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:91517833C>G	uc002bqm.2	-	10	1489	c.1332G>C	c.(1330-1332)GAG>GAC	p.E444D	PRC1_uc002bqn.2_Missense_Mutation_p.E444D|PRC1_uc002bqo.2_Missense_Mutation_p.E444D|PRC1_uc010uqs.1_Missense_Mutation_p.E403D	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	444	Potential.|Spectrin-fold.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GCTTGGCTCTCTCTTTCTCCA	0.463		NaN											0	0	0	0.01441	0	140	127									
LINS1	55180	broad.mit.edu	37	15	101115276	101115276	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:101115276C>T	uc002bwe.2	-	5	838	c.547G>A	c.(547-549)GAG>AAG	p.E183K	LINS1_uc002bwd.2_5'Flank|LINS1_uc002bwf.2_Missense_Mutation_p.E183K|LINS1_uc002bwg.2_Missense_Mutation_p.E183K|LINS1_uc002bwh.2_Missense_Mutation_p.E183K|LINS1_uc010usa.1_Missense_Mutation_p.E64K|LINS1_uc002bwi.2_Missense_Mutation_p.E183K	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	183											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TTATTACTCTCAGAGTATTCA	0.313		NaN											0	0	0	0.008361	0	31	88									
CHSY1	22856	broad.mit.edu	37	15	101718244	101718244	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:101718244C>T	uc002bwt.1	-	4	2241	c.1758G>A	c.(1756-1758)CTG>CTA	p.L586L	CHSY1_uc010usd.1_Silent_p.L314L	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	586	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AATCTCTCATCAGTTCAACTT	0.478		NaN											0	0	0	0.003163	0	16	45									
PRR25	388199	broad.mit.edu	37	16	863601	863601	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:863601C>G	uc010uut.1	+	3	949	c.949C>G	c.(949-951)CTG>GTG	p.L317V		NM_001013638	NP_001013660	Q96S07	PRR25_HUMAN	proline rich 25	317										large_intestine(1)	1						TGGCCGGCATCTGGAGACGTC	0.721		NaN											0	0	0	0.004672	0	3	4									
TRAF7	84231	broad.mit.edu	37	16	2215900	2215900	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:2215900C>T	uc002cow.2	+	3	201	c.102C>T	c.(100-102)TTC>TTT	p.F34F		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	34					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						AAACGACCTTCGGACCCGCCT	0.607		NaN											0	0	0	0.001984	0	6	21									
SRRM2	23524	broad.mit.edu	37	16	2812535	2812535	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:2812535C>T	uc002crk.2	+	11	2555	c.2006C>T	c.(2005-2007)TCA>TTA	p.S669L	SRRM2_uc002crj.1_Missense_Mutation_p.S573L|SRRM2_uc002crl.1_Missense_Mutation_p.S669L|SRRM2_uc010bsu.1_Missense_Mutation_p.S573L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	669	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CGTGGCCGCTCACGCTCTAGA	0.617		NaN											0	0	0	0.010818	0	28	52									
SRRM2	23524	broad.mit.edu	37	16	2818133	2818133	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:2818133C>G	uc002crk.2	+	11	8153	c.7604C>G	c.(7603-7605)TCG>TGG	p.S2535W	SRRM2_uc002crj.1_Missense_Mutation_p.S2439W|SRRM2_uc002crl.1_Missense_Mutation_p.S2535W|SRRM2_uc010bsu.1_Missense_Mutation_p.S2439W	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2535	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGTtcctcctcgtcgtcgtcg	0.408		NaN											0	0	0	0.006214	0	6	9									
SRRM2	23524	broad.mit.edu	37	16	2819183	2819183	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:2819183C>G	uc002crk.2	+	12	8468	c.7919C>G	c.(7918-7920)TCT>TGT	p.S2640C		NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2640	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						tcctcctcatcttcctcctcc	0.284		NaN											0	0	0	0.00623	0	41	41									
MEFV	4210	broad.mit.edu	37	16	3293307	3293307	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:3293307C>G	uc002cun.1	-	10	2220	c.2180G>C	c.(2179-2181)GGA>GCA	p.G727A		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	727	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	GGAGATGCTTCCAACTCTGTA	0.532		NaN											0	0	0	0.007413	0	20	55									
BTBD12	84464	broad.mit.edu	37	16	3640211	3640211	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:3640211G>A	uc002cvp.2	-	12	4055	c.3428C>T	c.(3427-3429)TCC>TTC	p.S1143F		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1143	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						GTTCAGTTTGGATGAAGATTT	0.448		NaN						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				0	0	0	0.01441	0	65	24									
BTBD12	84464	broad.mit.edu	37	16	3641190	3641190	+	Missense_Mutation	SNP	C	C	T	rs143730668		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:3641190C>T	uc002cvp.2	-	12	3076	c.2449G>A	c.(2449-2451)GAA>AAA	p.E817K		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	817	Potential.|Interaction with PLK1 and TERF2-TERF2IP.|Glu-rich.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						CTCAAGAGTTCCTGGAAATTC	0.498		NaN						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia		OREG0032061	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.008361	0	29	82									
PMM2	5373	broad.mit.edu	37	16	8941604	8941604	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:8941604C>T	uc002czf.3	+	8	733	c.663C>T	c.(661-663)TTC>TTT	p.F221F	PMM2_uc010uyf.1_RNA|PMM2_uc010uyg.1_Silent_p.F138F|PMM2_uc010uyh.1_Silent_p.F96F|PMM2_uc010buj.2_RNA|PMM2_uc010uyi.1_Silent_p.F74F|PMM2_uc002czg.1_5'Flank	NM_000303	NP_000294	O15305	PMM2_HUMAN	phosphomannomutase 2	221					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	phosphomannomutase activity			ovary(1)	1						ATGAGATCTTCACAGACCCCA	0.597		NaN											0	0	0	0.004289	0	36	17									
USP7	7874	broad.mit.edu	37	16	9009183	9009183	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:9009183C>T	uc002czl.2	-	10	1205	c.1006G>A	c.(1006-1008)GAA>AAA	p.E336K	USP7_uc010uyk.1_Missense_Mutation_p.E237K|USP7_uc010uyj.1_Missense_Mutation_p.E237K|USP7_uc002czk.2_Missense_Mutation_p.E320K|USP7_uc010uyl.1_RNA	NM_003470	NP_003461	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7	336					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)	3						TAGTCTACTTCTTTACACTGG	0.299		NaN											0	0	0	0.01441	0	45	32									
TXNDC11	51061	broad.mit.edu	37	16	11792135	11792135	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:11792135T>G	uc010buu.1	-	8	1096	c.1034A>C	c.(1033-1035)AAG>ACG	p.K345T	TXNDC11_uc002dbg.1_Missense_Mutation_p.K318T	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	345					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						TAAGGCCCACTTACAGATGTT	0.557		NaN											0	0	0	0.004878	0	36	16									
RSL1D1	26156	broad.mit.edu	37	16	11933795	11933795	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:11933795C>G	uc002dbp.1	-	8	976	c.903G>C	c.(901-903)GAG>GAC	p.E301D	RSL1D1_uc010buv.1_Missense_Mutation_p.E300D|RSL1D1_uc010uyw.1_Missense_Mutation_p.E81D|RSL1D1_uc010buw.2_RNA	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	301	Potential.				regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						tcttcttcctctccttttgtt	0.254		NaN											0	0	0	0.003755	0	38	65									
MYH11	4629	broad.mit.edu	37	16	15841995	15841995	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:15841995C>A	uc002ddy.2	-	17	2196	c.2089G>T	c.(2089-2091)GAG>TAG	p.E697*	MYH11_uc002ddv.2_Nonsense_Mutation_p.E704*|MYH11_uc002ddw.2_Nonsense_Mutation_p.E697*|MYH11_uc002ddx.2_Nonsense_Mutation_p.E704*|MYH11_uc010bvg.2_Nonsense_Mutation_p.E529*	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	697	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CGCAGCTGCTCCAGCACCAGG	0.622		NaN	T	CBFB	AML								1	0	1.22574e-08	0.014323	1.26901e-08	20	8									
ABCC1	4363	broad.mit.edu	37	16	16215927	16215927	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:16215927C>T	uc010bvi.2	+	24	3661	c.3486C>T	c.(3484-3486)GTC>GTT	p.V1162V	ABCC1_uc010bvj.2_Silent_p.V1103V|ABCC1_uc010bvk.2_Silent_p.V1106V|ABCC1_uc010bvl.2_Silent_p.V1162V|ABCC1_uc010bvm.2_Silent_p.V1047V|ABCC1_uc002del.3_Silent_p.V1056V	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	1162	Cytoplasmic.|ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGCTGGGGGTCAGCGTCATTC	0.607		NaN											0	0	0	0.013537	0	13	50									
TMC7	79905	broad.mit.edu	37	16	19041668	19041668	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:19041668G>A	uc002dfq.2	+	6	964	c.834G>A	c.(832-834)CTG>CTA	p.L278L	TMC7_uc010vao.1_Silent_p.L278L|TMC7_uc002dfp.2_Silent_p.L278L|TMC7_uc010vap.1_Silent_p.L168L	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	278	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						CCCTGGCCCTGAGCCTTCTTT	0.473		NaN											0	0	0	0.01441	0	53	56									
LOC81691	81691	broad.mit.edu	37	16	20835811	20835811	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:20835811G>A	uc002dhv.2	+	7	930	c.667G>A	c.(667-669)GCA>ACA	p.A223T	ERI2_uc002dht.3_Intron|LOC81691_uc002dhx.2_Missense_Mutation_p.A223T|LOC81691_uc002dhw.2_Intron|LOC81691_uc002dhy.3_Missense_Mutation_p.A223T	NM_030941	NP_112203	Q96IC2	REXON_HUMAN	exonuclease NEF-sp isoform 1	223						nucleolus	exonuclease activity|nucleotide binding|RNA binding			ovary(1)|kidney(1)	2						TGGTTCTATAGCAGACAATAG	0.348		NaN											0	0	0	0.008291	0	10	68									
DNAH3	55567	broad.mit.edu	37	16	21170741	21170741	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:21170741C>T	uc010vbe.1	-	1	22	c.22G>A	c.(22-24)GAG>AAG	p.E8K	TMEM159_uc002dif.3_Intron|TMEM159_uc002dig.3_Intron|TMEM159_uc010vbf.1_Intron|TMEM159_uc002dih.3_Intron	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	8	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGTGTGAGCTCGAGGCGCCCT	0.627		NaN											0	0	0	0.01441	0	44	38									
ZP2	7783	broad.mit.edu	37	16	21214522	21214522	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:21214522C>T	uc002dii.2	-	10	1023	c.1023G>A	c.(1021-1023)CTG>CTA	p.L341L	ZP2_uc010bwn.1_Silent_p.L380L	NM_003460	NP_003451	Q05996	ZP2_HUMAN	zona pellucida glycoprotein 2 preproprotein	341	Extracellular (Potential).				binding of sperm to zona pellucida|intracellular protein transport	endoplasmic reticulum|Golgi apparatus|integral to membrane|multivesicular body|plasma membrane|proteinaceous extracellular matrix|stored secretory granule	acrosin binding|coreceptor activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(48;0.0573)		GGAGAAAGGTCAGCTTGAGTG	0.433		NaN											0	0	0	0.010729	0	11	53									
COG7	91949	broad.mit.edu	37	16	23436192	23436192	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:23436192G>A	uc002dlo.2	-	7	1075	c.887C>T	c.(886-888)TCC>TTC	p.S296F		NM_153603	NP_705831	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	296					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0				GBM - Glioblastoma multiforme(48;0.0401)		GCTGAGGCAGGAGGGCAGCGA	0.642		NaN											0	0	0	0.008871	0	19	47									
GGA2	23062	broad.mit.edu	37	16	23492071	23492071	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:23492071C>T	uc002dlq.2	-	10	977	c.901G>A	c.(901-903)GAC>AAC	p.D301N	GGA2_uc010bxo.1_RNA	NM_015044	NP_055859	Q9UJY4	GGA2_HUMAN	ADP-ribosylation factor binding protein 2	301	GAT.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|clathrin-coated vesicle|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.0386)		GTGAGGAGGTCATTTGCCTGG	0.493		NaN											0	0	0	0.01441	0	265	46									
TNRC6A	27327	broad.mit.edu	37	16	24802299	24802299	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:24802299C>T	uc002dmm.2	+	6	2450	c.2336C>T	c.(2335-2337)TCT>TTT	p.S779F	TNRC6A_uc010bxs.2_Missense_Mutation_p.S526F|TNRC6A_uc010vcc.1_Missense_Mutation_p.S526F|TNRC6A_uc002dmn.2_Missense_Mutation_p.S526F|TNRC6A_uc002dmo.2_Missense_Mutation_p.S526F	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	779	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GATACCTCATCTGTATCAGGG	0.517		NaN											0	0	0	0.004482	0	9	121									
TNRC6A	27327	broad.mit.edu	37	16	24817006	24817006	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:24817006G>A	uc002dmm.2	+	15	4317	c.4203G>A	c.(4201-4203)CTG>CTA	p.L1401L	TNRC6A_uc010bxs.2_Silent_p.L1148L|TNRC6A_uc002dmn.2_Silent_p.L1099L|TNRC6A_uc002dmo.2_Silent_p.L1040L|TNRC6A_uc002dmp.2_Silent_p.L2L|TNRC6A_uc002dmq.2_Silent_p.L68L	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1401					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TAGCCATGCTGAACCAGCTAT	0.403		NaN											0	0	0	0.010771	0	45	421									
XPO6	23214	broad.mit.edu	37	16	28128716	28128716	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:28128716G>A	uc002dpa.1	-	15	2428	c.1927C>T	c.(1927-1929)CAC>TAC	p.H643Y	XPO6_uc002dpb.1_Missense_Mutation_p.H629Y|XPO6_uc010vcp.1_Missense_Mutation_p.H643Y	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	643					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						TTCTGCCGGTGAACTTCACTG	0.488		NaN											0	0	0	0.00632	0	28	147									
NFATC2IP	84901	broad.mit.edu	37	16	28975091	28975091	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:28975091C>G	uc002dru.2	+	8	1182	c.1167C>G	c.(1165-1167)CTC>CTG	p.L389L	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Silent_p.L110L|NFATC2IP_uc002drv.2_Silent_p.L108L|NFATC2IP_uc010vdh.1_Silent_p.L97L	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	389	Ubiquitin-like.					cytoplasm|nucleus				ovary(1)	1						GACGGAAGCTCTCCTTCTTCT	0.547		NaN											0	0	0	0.004007	0	17	59									
KIF22	3835	broad.mit.edu	37	16	29814250	29814250	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:29814250G>A	uc002dts.3	+	9	1465	c.1441G>A	c.(1441-1443)GAG>AAG	p.E481K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|KIF22_uc010vdv.1_Missense_Mutation_p.E413K|KIF22_uc010vdw.1_Missense_Mutation_p.E413K|KIF22_uc010bzf.2_Missense_Mutation_p.E413K|KIF22_uc002dtt.1_5'Flank|KIF22_uc002frc.1_5'Flank	NM_007317	NP_015556	Q14807	KIF22_HUMAN	kinesin family member 22	481	Potential.				blood coagulation|DNA repair|microtubule-based movement|mitosis	cytosol|kinetochore|microtubule|nucleus	ATP binding|DNA binding|microtubule motor activity|protein binding				0						GAAGGACCTAGAGATTGAGGT	0.552		NaN											0	0	0	0.004656	0	24	28									
SEPT1	1731	broad.mit.edu	37	16	30390351	30390351	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:30390351C>T	uc002dxy.2	-	10	1101	c.914G>A	c.(913-915)CGA>CAA	p.R305Q	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_Missense_Mutation_p.R130Q	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	305					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			GCGGCTGGCTCGATCGCGAGC	0.682		NaN											0	0	0	0.00245	0	8	4									
SEPT1	1731	broad.mit.edu	37	16	30390418	30390418	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:30390418C>T	uc002dxy.2	-	10	1034	c.847G>A	c.(847-849)GAT>AAT	p.D283N	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_Missense_Mutation_p.D108N	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	283					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			TAGAGCAGATCGTGCGTCACC	0.667		NaN											0	0	0	0.013537	0	11	45									
SRCAP	10847	broad.mit.edu	37	16	30740403	30740403	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:30740403C>T	uc002dze.1	+	26	6160	c.5775C>T	c.(5773-5775)TTC>TTT	p.F1925F	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Silent_p.F1720F	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1925					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			TCCTGGATTTCTGTACCCTGC	0.617		NaN											0	0	0	0.001855	0	12	54									
ZNF646	9726	broad.mit.edu	37	16	31088003	31088003	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:31088003G>T	uc002eap.2	+	2	647	c.358G>T	c.(358-360)GAG>TAG	p.E120*	ZNF668_uc002eao.2_5'Flank	NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						CCTCCAGGGTGAGACGGTGTC	0.582		NaN											1	0	1.33834e-09	0.007413	1.38957e-09	20	17									
ZNF646	9726	broad.mit.edu	37	16	31090756	31090756	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:31090756C>T	uc002eap.2	+	2	3400	c.3111C>T	c.(3109-3111)TGC>TGT	p.C1037C		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1037					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						ACAGCCTCTGCATCCAGGGTG	0.597		NaN											0	0	0	0.006999	0	37	104									
SHCBP1	79801	broad.mit.edu	37	16	46649952	46649952	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:46649952G>A	uc002eec.3	-	4	542	c.502C>T	c.(502-504)CTG>TTG	p.L168L		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	168										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				TGCTCCTTCAGATCAAGGAGC	0.517		NaN											0	0	0	0.014323	0	19	50									
NOD2	64127	broad.mit.edu	37	16	50745896	50745896	+	Missense_Mutation	SNP	G	G	A	rs143782684		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:50745896G>A	uc002egm.1	+	4	2179	c.2074G>A	c.(2074-2076)GAG>AAG	p.E692K	NOD2_uc010cbk.1_Missense_Mutation_p.E665K|NOD2_uc002egl.1_Missense_Mutation_p.E470K|NOD2_uc010cbl.1_Missense_Mutation_p.E470K|NOD2_uc010cbm.1_Missense_Mutation_p.E470K|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	692					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CCTGCTGGCTGAGTGCCAGAC	0.672		NaN											0	0	0	0.004007	0	15	34									
RBL2	5934	broad.mit.edu	37	16	53514621	53514621	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:53514621C>G	uc002ehi.3	+	20	3142	c.3024C>G	c.(3022-3024)TTC>TTG	p.F1008L	RBL2_uc002ehj.2_Missense_Mutation_p.F718L|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1008	Domain B.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						TCATTCAGTTCTACAACAACA	0.453		NaN											0	0	0	0.01441	0	94	45									
CETP	1071	broad.mit.edu	37	16	57016076	57016076	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:57016076G>A	uc002eki.2	+	14	1306	c.1249_splice	c.e14-1	p.S417_splice	CETP_uc002ekj.2_Splice_Site_p.S357_splice	NM_000078	NP_000069	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma						cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			central_nervous_system(1)|skin(1)	2						TTGATTGGCAGAGCAGCTCCG	0.577		NaN											0	0	0	0.007835	0	38	28									
NLRC5	84166	broad.mit.edu	37	16	57062240	57062240	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:57062240G>A	uc002ekk.1	+	8	2411	c.2186G>A	c.(2185-2187)CGA>CAA	p.R729Q	NLRC5_uc010ccq.1_RNA|NLRC5_uc002ekn.2_Intron|NLRC5_uc002ekl.2_Missense_Mutation_p.R534Q|NLRC5_uc002ekm.2_Missense_Mutation_p.R534Q|NLRC5_uc010ccr.1_RNA	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	729	LRR 2.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				ATCACTGCCCGAGGCATCAGC	0.552		NaN											0	0	0	0.010771	0	43	117									
CPNE2	221184	broad.mit.edu	37	16	57181557	57181557	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:57181557C>G	uc002eks.1	+	16	1863	c.1634C>G	c.(1633-1635)TCG>TGG	p.S545W	CPNE2_uc010cct.1_Missense_Mutation_p.S571W|CPNE2_uc010ccu.1_Missense_Mutation_p.S545W|CPNE2_uc002ekt.1_3'UTR	NM_152727	NP_689940	Q96FN4	CPNE2_HUMAN	copine II	545										central_nervous_system(1)|skin(1)	2		all_neural(199;0.224)				CCCACCAACTCGGAGCCCGCC	0.602		NaN											0	0	0	0.004482	0	8	13									
CX3CL1	6376	broad.mit.edu	37	16	57416765	57416765	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:57416765C>T	uc002eli.2	+	3	1082	c.1015C>T	c.(1015-1017)CGG>TGG	p.R339W		NM_002996	NP_002987	P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1 precursor	339	Mucin-like stalk.|Extracellular (Potential).	Cleavage; to produce soluble form (Potential).			cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity				0						GGCTGCCACCCGGAGGCAGGC	0.657		NaN											0	0	0	0.001855	0	9	26									
CDH16	1014	broad.mit.edu	37	16	66945993	66945993	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:66945993C>G	uc002eql.2	-	13	1672	c.1599G>C	c.(1597-1599)CAG>CAC	p.Q533H	CDH16_uc010cdy.2_Missense_Mutation_p.Q533H|CDH16_uc002eqm.2_Missense_Mutation_p.Q436H	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	533	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TCGCCACACTCTGCACCACCA	0.637		NaN											0	0	0	0.001984	0	6	22									
HSF4	3299	broad.mit.edu	37	16	67203215	67203215	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:67203215G>C	uc002erl.1	+	14	2253	c.1288G>C	c.(1288-1290)GAG>CAG	p.E430Q	HSF4_uc002erm.1_Missense_Mutation_p.E400Q|HSF4_uc002ern.1_RNA|HSF4_uc010cec.1_Intron|NOL3_uc010vjc.1_5'Flank	NM_001040667	NP_001035757	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4 isoform b	430					response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GGGTGAGCCTGAGCTGGCGGT	0.597		NaN											0	0	0	0.001168	0	6	13									
NOL3	8996	broad.mit.edu	37	16	67208208	67208208	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:67208208G>A	uc010vjd.1	+	2	329	c.322G>A	c.(322-324)GAG>AAG	p.E108K	NOL3_uc010vjc.1_Missense_Mutation_p.E108K|NOL3_uc002erp.2_Missense_Mutation_p.E46K			O60936	NOL3_HUMAN	RecName: Full=Nucleolar protein 3; AltName: Full=Apoptosis repressor with CARD; AltName: Full=Muscle-enriched cytoplasmic protein;          Short=Myp; AltName: Full=Nucleolar protein of 30 kDa;          Short=Nop30;	46	CARD.				anti-apoptosis|apoptosis|mRNA processing|RNA splicing	cytosol|nucleolus	identical protein binding|RNA binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		GCCAGAGTACGAGGCATTGGA	0.706		NaN											0	0	0	0.009096	0	4	8									
KCTD19	146212	broad.mit.edu	37	16	67324826	67324826	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:67324826C>G	uc002esu.2	-	15	2680	c.2629G>C	c.(2629-2631)GAC>CAC	p.D877H	KCTD19_uc002est.2_Missense_Mutation_p.D649H|KCTD19_uc010vjj.1_Missense_Mutation_p.D620H	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	877						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GTGTGCCGGTCATCCTTGAAG	0.607		NaN											0	0	0	0.000602	0	5	10									
CENPT	80152	broad.mit.edu	37	16	67865789	67865789	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:67865789C>G	uc002eun.3	-	8	940	c.391G>C	c.(391-393)GAG>CAG	p.E131Q	CENPT_uc002eum.3_Missense_Mutation_p.E131Q|CENPT_uc010vkc.1_5'UTR|CENPT_uc010vkd.1_Intron|CENPT_uc010vke.1_Missense_Mutation_p.E28Q	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	131					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		AGTTGCAGCTCCAGGCTATAA	0.557		NaN											0	0	0	0.001168	0	6	13									
TMED6	146456	broad.mit.edu	37	16	69385466	69385466	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:69385466C>T	uc002exc.1	-	1	224	c.191G>A	c.(190-192)GGA>GAA	p.G64E		NM_144676	NP_653277	Q8WW62	TMED6_HUMAN	transmembrane emp24 protein transport domain	64	Lumenal (Potential).|GOLD.				transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1						ATAGAAGTATCCAGTCTGGTG	0.483		NaN											0	0	0	0.003954	0	24	44									
NFAT5	10725	broad.mit.edu	37	16	69726682	69726682	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:69726682C>T	uc002exm.1	+	12	4108	c.2900C>T	c.(2899-2901)TCT>TTT	p.S967F	NFAT5_uc002exi.2_Missense_Mutation_p.S891F|NFAT5_uc002exj.1_Missense_Mutation_p.S891F|NFAT5_uc002exk.1_Missense_Mutation_p.S891F|NFAT5_uc002exl.1_Missense_Mutation_p.S985F|NFAT5_uc002exn.1_Missense_Mutation_p.S984F|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	967	Poly-Thr.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AATGAAACTTCTACAACTACC	0.428		NaN											0	0	0	0.006122	0	19	58									
AARS	16	broad.mit.edu	37	16	70301626	70301626	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:70301626G>A	uc002eyn.1	-	9	1268	c.1158C>T	c.(1156-1158)CTC>CTT	p.L386L	AARS_uc010vlu.1_Silent_p.L216L	NM_001605	NP_001596	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	386					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	GCCCTCTGCTGAGAGTCTTGA	0.517		NaN									OREG0023913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	19	37									
FUK	197258	broad.mit.edu	37	16	70504931	70504931	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:70504931G>A	uc002eyy.2	+	12	1184	c.1126G>A	c.(1126-1128)GTC>ATC	p.V376I	FUK_uc010cft.2_Missense_Mutation_p.V408I|FUK_uc002eyz.2_5'UTR	NM_145059	NP_659496	Q8N0W3	FUK_HUMAN	fucokinase	376						cytoplasm	ATP binding|fucokinase activity			ovary(1)	1		Ovarian(137;0.0694)				GGAGGGCCCTGTCCAGCTGGG	0.682		NaN											0	0	0	0.000602	0	4	3									
COG4	25839	broad.mit.edu	37	16	70546183	70546183	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:70546183C>T	uc002ezc.2	-	5	708	c.697G>A	c.(697-699)GAG>AAG	p.E233K	COG4_uc002ezb.2_5'Flank|COG4_uc010cfu.2_RNA|COG4_uc002ezd.2_Missense_Mutation_p.E233K|COG4_uc002eze.2_5'UTR	NM_015386	NP_056201	Q9H9E3	COG4_HUMAN	component of oligomeric golgi complex 4	229					Golgi organization|Golgi vesicle prefusion complex stabilization|protein transport|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding				0		Ovarian(137;0.0694)				AATCCCTCCTCATGCAAACCC	0.522		NaN											0	0	0	0.00278	0	22	30									
CDH13	1012	broad.mit.edu	37	16	83817067	83817067	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr16:83817067C>T	uc002fgx.2	+	13	2244	c.2124C>T	c.(2122-2124)TTC>TTT	p.F708F	CDH13_uc010vns.1_Silent_p.F755F|CDH13_uc010vnt.1_Silent_p.F454F|CDH13_uc010vnu.1_Silent_p.F669F	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	708					adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TCAGCCTCTTCAGCTTAGCTT	0.522		NaN											0	0	0	0.010818	0	29	41									
ZZEF1	23140	broad.mit.edu	37	17	4045890	4045890	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:4045890G>A	uc002fxe.2	-	1	364	c.300C>T	c.(298-300)TTC>TTT	p.F100F	ZZEF1_uc002fxk.1_Silent_p.F100F|CYB5D2_uc002fxm.3_5'Flank|CYB5D2_uc010cko.2_5'Flank|CYB5D2_uc002fxl.3_5'Flank	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	100							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCAGCTCCCGGAACTGCTCCA	0.716		NaN											0	0	0	0.013537	0	8	4									
PELP1	27043	broad.mit.edu	37	17	4577935	4577935	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:4577935C>T	uc002fyi.3	-	13	1678	c.1452G>A	c.(1450-1452)GGG>GGA	p.G484G	PELP1_uc010vsf.1_Silent_p.G337G	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	484					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						TCTGCAAACTCCCATCAGGGC	0.577		NaN											0	0	0	0.003163	0	15	7									
USP6	9098	broad.mit.edu	37	17	5058719	5058719	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5058719G>A	uc002gau.1	+	31	4876	c.2646G>A	c.(2644-2646)ATG>ATA	p.M882I	USP6_uc002gav.1_Missense_Mutation_p.M882I|USP6_uc010ckz.1_Missense_Mutation_p.M565I	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	882					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						ACATACAGATGAGGACAGAAC	0.453		NaN	T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								0	0	0	0.01441	0	71	30									
ZNF594	84622	broad.mit.edu	37	17	5086360	5086360	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5086360G>A	uc010cla.1	-	2	1348	c.1192C>T	c.(1192-1194)CAT>TAT	p.H398Y		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	398	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TCTCCTGTATGAGTTACCTGA	0.423		NaN											0	0	0	0.01441	0	263	89									
NUP88	4927	broad.mit.edu	37	17	5322700	5322700	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5322700C>T	uc002gbo.1	-	1	297	c.271G>A	c.(271-273)GAA>AAA	p.E91K	NUP88_uc010vsx.1_Missense_Mutation_p.E91K|NUP88_uc010cle.1_Missense_Mutation_p.E91K|NUP88_uc010vsy.1_Missense_Mutation_p.E91K|RPAIN_uc010vsz.1_5'Flank|RPAIN_uc002gbp.1_5'Flank|RPAIN_uc010vta.1_5'Flank|RPAIN_uc002gbq.2_5'Flank|RPAIN_uc010vtb.1_5'Flank|RPAIN_uc002gbs.2_5'Flank|RPAIN_uc002gbt.2_5'Flank|RPAIN_uc002gbu.2_5'Flank|RPAIN_uc002gbv.2_5'Flank|RPAIN_uc002gbr.2_5'Flank|RPAIN_uc002gbw.2_5'Flank	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	91					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						GCGGGCTCTTCGCCGCCGCCG	0.602		NaN											0	0	0	0.007413	0	20	27									
NUP88	4927	broad.mit.edu	37	17	5322772	5322772	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5322772C>G	uc002gbo.1	-	1	225	c.199G>C	c.(199-201)GAG>CAG	p.E67Q	NUP88_uc010vsx.1_Missense_Mutation_p.E67Q|NUP88_uc010cle.1_Missense_Mutation_p.E67Q|NUP88_uc010vsy.1_Missense_Mutation_p.E67Q|RPAIN_uc010vsz.1_5'Flank|RPAIN_uc002gbp.1_5'Flank|RPAIN_uc010vta.1_5'Flank|RPAIN_uc002gbq.2_5'Flank|RPAIN_uc010vtb.1_5'Flank|RPAIN_uc002gbs.2_5'Flank|RPAIN_uc002gbt.2_5'Flank|RPAIN_uc002gbu.2_5'Flank|RPAIN_uc002gbv.2_5'Flank|RPAIN_uc002gbr.2_5'Flank|RPAIN_uc002gbw.2_5'Flank	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	67					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						AGGAAAAGCTCTCCGCCGAGG	0.632		NaN											0	0	0	0.006999	0	37	41									
NLRP1	22861	broad.mit.edu	37	17	5418329	5418329	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:5418329C>T	uc002gci.2	-	17	4722	c.4167G>A	c.(4165-4167)CTG>CTA	p.L1389L	NLRP1_uc002gcg.1_Intron|NLRP1_uc002gck.2_Silent_p.L1345L|NLRP1_uc002gcj.2_Silent_p.L1359L|NLRP1_uc002gcl.2_Silent_p.L1315L|NLRP1_uc002gch.3_Silent_p.L1345L	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1389	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				CTCGGGCTATCAGCTGCTCTC	0.577		NaN											0	0	0	0.007413	0	20	19									
PITPNM3	83394	broad.mit.edu	37	17	6358809	6358809	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:6358809C>T	uc002gdd.3	-	20	2925	c.2774G>A	c.(2773-2775)AGA>AAA	p.R925K	PITPNM3_uc010cln.2_Missense_Mutation_p.R889K|PITPNM3_uc010clm.2_Missense_Mutation_p.R408K|PITPNM3_uc002gdc.3_Missense_Mutation_p.R516K	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	925					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		TGACATGGTTCTGCGCAGGTG	0.677		NaN											0	0	0	0.004007	0	16	5									
DVL2	1856	broad.mit.edu	37	17	7129501	7129501	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7129501G>A	uc002gez.1	-	15	2176	c.1894C>T	c.(1894-1896)CGG>TGG	p.R632W	uc002gey.1_5'Flank|MIR324_hsa-mir-324|MI0000813_5'Flank|DVL2_uc010vtr.1_Missense_Mutation_p.R626W	NM_004422	NP_004413	O14641	DVL2_HUMAN	dishevelled 2	632					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			lung(1)|kidney(1)	2						CCACCCCGCCGAAGGCTGCCC	0.716		NaN											0	0	0	0.004482	0	6	31									
GABARAP	11337	broad.mit.edu	37	17	7145647	7145647	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7145647C>T	uc002gfb.2	-	1	107	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PHF23_uc002gfa.2_5'Flank|PHF23_uc010vtt.1_5'Flank|PHF23_uc010cma.2_5'Flank	NM_007278	NP_009209	O95166	GBRAP_HUMAN	GABA(A) receptor-associated protein	1	Interaction with beta-tubulin.				protein targeting|synaptic transmission	autophagic vacuole membrane|Golgi membrane|microtubule|plasma membrane	beta-tubulin binding|GABA receptor binding				0						ACACGAACTTCATCCTCCCGG	0.672		NaN											0	0	0	0.008361	0	32	7									
KCTD11	147040	broad.mit.edu	37	17	7256381	7256381	+	Silent	SNP	G	G	A	rs144008002		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7256381G>A	uc002gge.3	+	1	1174	c.120G>A	c.(118-120)CTG>CTA	p.L40L	TMEM95_uc002ggf.1_5'Flank|TMEM95_uc002ggg.1_5'Flank|TMEM95_uc002ggh.1_5'Flank	NM_001002914	NP_001002914	Q693B1	KCD11_HUMAN	potassium channel tetramerisation domain	40	BTB.				cell cycle|regulation of growth	voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Prostate(122;0.157)				TCAATTTCCTGAGGCTGGGCC	0.667		NaN											0	0	0	0.008361	0	32	6									
SOX15	6665	broad.mit.edu	37	17	7492785	7492785	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7492785C>T	uc002ghy.1	-	2	358	c.210G>A	c.(208-210)CAG>CAA	p.Q70Q	MPDU1_uc010vuc.1_Intron|SOX15_uc002ghz.1_Silent_p.Q70Q	NM_006942	NP_008873	O60248	SOX15_HUMAN	SRY-box 15	70	HMG box.			QQ -> HE (in Ref. 5; CAA51520).	chromatin organization|male gonad development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						TCTTGGGGTTCTGCTGCGCCA	0.682		NaN									OREG0024139	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	12	9									
TP53	7157	broad.mit.edu	37	17	7572986	7572986	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7572986G>A	uc002gim.2	-	11	1317	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_RNA|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.Q243*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.Q375*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	375	Basic (repression of DNA-binding).|Interaction with CARM1.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.?(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGTAGACTGACCCTTTTTG	0.527		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	68	24									
TP53	7157	broad.mit.edu	37	17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7577127C>T	uc002gim.2	-	8	1005	c.811G>A	c.(811-813)GAG>AAG	p.E271K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E271K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E139K|TP53_uc010cng.1_Missense_Mutation_p.E139K|TP53_uc002gii.1_Missense_Mutation_p.E139K|TP53_uc010cnh.1_Missense_Mutation_p.E271K|TP53_uc010cni.1_Missense_Mutation_p.E271K|TP53_uc002gij.2_Missense_Mutation_p.E271K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	271	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> A (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(22)|p.E271*(14)|p.0?(7)|p.E271V(5)|p.E271Q(3)|p.E271G(3)|p.E271D(3)|p.?(2)|p.G266_E271delGRNSFE(2)|p.E271E(2)|p.E271fs*73(1)|p.E258fs*71(1)|p.E271_R273delEVR(1)|p.F270fs*72(1)|p.S269fs*21(1)|p.L265_K305del41(1)|p.F270_D281del12(1)|p.E271P(1)|p.E271del(1)|p.S269fs*34(1)|p.E271fs*34(1)|p.E271fs*35(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.014323	0	23	6									
DNAH2	146754	broad.mit.edu	37	17	7702525	7702525	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7702525C>T	uc002giu.1	+	55	8678	c.8664C>T	c.(8662-8664)ATC>ATT	p.I2888I		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2888	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACCTGCACATCGTGCTCTGCC	0.592		NaN											0	0	0	0.007291	0	30	13									
LSMD1	84316	broad.mit.edu	37	17	7760451	7760451	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7760451G>A	uc002giz.2	-	2	246	c.147C>T	c.(145-147)CTC>CTT	p.L49L	LSMD1_uc002gja.2_Silent_p.L97L|CYB5D1_uc010cnn.1_5'Flank|CYB5D1_uc002gjb.3_5'Flank			Q9BRA0	LSMD1_HUMAN	RecName: Full=LSM domain-containing protein 1; AltName: Full=Phosphonoformate immuno-associated protein 2;	49	Potential.					cytoplasm|nucleus				ovary(1)	1		all_cancers(10;0.11)|Prostate(122;0.219)				TAGTCTTGTTGAGCAGCGCCT	0.642		NaN									OREG0024146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003755	0	32	82									
CHD3	1107	broad.mit.edu	37	17	7792337	7792337	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:7792337G>A	uc002gje.2	+	1	169	c.19G>A	c.(19-21)GTG>ATG	p.V7M	CHD3_uc002gjd.2_Intron|CHD3_uc002gjf.2_Missense_Mutation_p.V7M|CHD3_uc002gjg.1_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	7					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				GGCAGACACTGTGATCCTGTG	0.458		NaN											0	0	0	0.01441	0	50	17									
MYH10	4628	broad.mit.edu	37	17	8508259	8508259	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:8508259C>A	uc002gll.2	-	3	483	c.387G>T	c.(385-387)AAG>AAT	p.K129N	MYH10_uc002glm.2_Missense_Mutation_p.K129N|MYH10_uc010cnx.2_Missense_Mutation_p.K129N	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	129	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTGGAAGATTCTTGTAAGGGT	0.303		NaN											1	0	9.16793e-09	0.00499	9.49614e-09	17	65									
PIK3R6	146850	broad.mit.edu	37	17	8725949	8725949	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:8725949G>A	uc002glq.1	-	16	1983	c.1743C>T	c.(1741-1743)GGC>GGT	p.G581G	PIK3R6_uc002glr.1_RNA|PIK3R6_uc002gls.1_RNA	NM_001010855	NP_001010855	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	581					platelet activation	cytosol					0						CCTCAGCCACGCCTCTCCTCC	0.607		NaN											0	0	0	0.010729	0	11	22									
NTN1	9423	broad.mit.edu	37	17	9143161	9143161	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:9143161C>T	uc002glw.3	+	7	1798	c.1691C>T	c.(1690-1692)TCT>TTT	p.S564F		NM_004822	NP_004813	O95631	NET1_HUMAN	netrin 1 precursor	564	NTR.				apoptosis|axon guidance		protein binding				0						GCGGAGGACTCTCCGGACCAG	0.637		NaN											0	0	0	0.00308	0	7	3									
NCOR1	9611	broad.mit.edu	37	17	15942956	15942956	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:15942956G>C	uc002gpo.2	-	44	6986	c.6746C>G	c.(6745-6747)TCT>TGT	p.S2249C	NCOR1_uc002gpn.2_Missense_Mutation_p.S2146C|NCOR1_uc002gpl.2_Missense_Mutation_p.S264C|NCOR1_uc002gpm.2_Missense_Mutation_p.S769C|NCOR1_uc010vwb.1_Missense_Mutation_p.S833C|NCOR1_uc010coy.2_Missense_Mutation_p.S1157C	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2249	Interaction with C1D (By similarity).|ID2 (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ATGGCCTCTAGAGCTAACTGA	0.433		NaN											0	0	0	0.001984	0	7	12									
ULK2	9706	broad.mit.edu	37	17	19708077	19708077	+	Missense_Mutation	SNP	C	C	A	rs138826045		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:19708077C>A	uc002gwm.3	-	15	1733	c.1224G>T	c.(1222-1224)AGG>AGT	p.R408S	ULK2_uc002gwn.2_Missense_Mutation_p.R408S	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	408					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GCTGATAATTCCTTATTTGAG	0.408		NaN											1	0	2.91434e-09	0.004878	3.023e-09	36	20									
VTN	7448	broad.mit.edu	37	17	26696647	26696647	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26696647G>C	uc002hbc.2	-	3	559	c.410C>G	c.(409-411)TCA>TGA	p.S137*	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron|SARM1_uc010crl.1_5'Flank	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	137					cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	CTCAGGCCTTGAGTCTATCCC	0.612		NaN											0	0	0	0.008291	0	10	37									
KIAA0100	9703	broad.mit.edu	37	17	26965042	26965042	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26965042C>G	uc002hbu.2	-	14	1682	c.1583G>C	c.(1582-1584)CGA>CCA	p.R528P		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	528						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					CTGAAGTCCTCGAATGGTACA	0.502		NaN											0	0	0	0.014323	0	22	31									
KIAA0100	9703	broad.mit.edu	37	17	26967622	26967622	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26967622C>T	uc002hbu.2	-	8	945	c.846G>A	c.(844-846)AAG>AAA	p.K282K	KIAA0100_uc002hbv.2_Silent_p.K282K|KIAA0100_uc010crr.1_Silent_p.K139K	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	282						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					TGTTCTCCATCTTAACCTTGA	0.463		NaN											0	0	0	0.004878	0	33	74									
KIAA0100	9703	broad.mit.edu	37	17	26967681	26967681	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26967681C>T	uc002hbu.2	-	8	886	c.787G>A	c.(787-789)GAG>AAG	p.E263K	KIAA0100_uc002hbv.2_Missense_Mutation_p.E263K|KIAA0100_uc010crr.1_Missense_Mutation_p.E120K	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	263						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGAGTTGGCTCAACTAAGTTT	0.448		NaN											0	0	0	0.00278	0	25	43									
KIAA0100	9703	broad.mit.edu	37	17	26967693	26967693	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:26967693C>T	uc002hbu.2	-	8	874	c.775G>A	c.(775-777)GAA>AAA	p.E259K	KIAA0100_uc002hbv.2_Missense_Mutation_p.E259K|KIAA0100_uc010crr.1_Missense_Mutation_p.E116K	NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	259						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					ACTAAGTTTTCTGTCACCTCT	0.463		NaN											0	0	0	0.014323	0	23	36									
TRAF4	9618	broad.mit.edu	37	17	27075418	27075418	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:27075418G>A	uc002hcs.2	+	5	709	c.601G>A	c.(601-603)GAG>AAG	p.E201K	TRAF4_uc002hcq.1_Intron	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	201	TRAF-type 2.				apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			CTGCACTAAGGAGTTCGTCTT	0.572		NaN											0	0	0	0.00499	0	16	19									
TRAF4	9618	broad.mit.edu	37	17	27076569	27076569	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:27076569G>A	uc002hcs.2	+	7	1495	c.1387G>A	c.(1387-1389)GAA>AAA	p.E463K	TRAF4_uc002hcq.1_Missense_Mutation_p.E188K	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	463					apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			TGCTGCTGTTGAACTGCCCCG	0.557		NaN											0	0	0	0.00333	0	22	52									
MYO18A	399687	broad.mit.edu	37	17	27438549	27438549	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:27438549G>A	uc002hdt.1	-	17	2951	c.2793C>T	c.(2791-2793)CAC>CAT	p.H931H	MYO18A_uc010wbc.1_Silent_p.H473H|MYO18A_uc002hds.2_Silent_p.H473H|MYO18A_uc010csa.1_Silent_p.H931H|MYO18A_uc002hdu.1_Silent_p.H931H|MYO18A_uc010wbd.1_Silent_p.H600H	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	931	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TGCCATGGCTGTGGCCCAGGA	0.572		NaN									OREG0024287	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	29									
BLMH	642	broad.mit.edu	37	17	28598396	28598396	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:28598396C>T	uc002hez.1	-	10	1276	c.1039G>A	c.(1039-1041)GAG>AAG	p.E347K	BLMH_uc010wbn.1_Missense_Mutation_p.E260K	NM_000386	NP_000377	Q13867	BLMH_HUMAN	bleomycin hydrolase	347					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1						AACACTAACTCATGGTCATAG	0.413		NaN											0	0	0	0.005443	0	27	54									
BLMH	642	broad.mit.edu	37	17	28601152	28601152	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:28601152C>T	uc002hez.1	-	7	946	c.709G>A	c.(709-711)GAC>AAC	p.D237N	BLMH_uc010wbn.1_Missense_Mutation_p.D150N	NM_000386	NP_000377	Q13867	BLMH_HUMAN	bleomycin hydrolase	237					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			ovary(1)	1						TTATCTTTGTCTCGATATTCC	0.438		NaN											0	0	0	0.00278	0	23	76									
CPD	1362	broad.mit.edu	37	17	28770948	28770948	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:28770948C>T	uc002hfb.1	+	11	2517	c.2502C>T	c.(2500-2502)CTC>CTT	p.L834L	CPD_uc010wbo.1_Silent_p.L587L|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	834	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						ACTGGCGTCTCTTGGTTCCAG	0.448		NaN											0	0	0	0.013114	0	45	182									
SUZ12	23512	broad.mit.edu	37	17	30302704	30302704	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:30302704G>A	uc002hgs.2	+	7	1017	c.795G>A	c.(793-795)ATG>ATA	p.M265I	SUZ12_uc002hgt.2_Missense_Mutation_p.M242I	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	265					negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				TTAATGGAATGATTAATGGAG	0.333		NaN	T	JAZF1	endometrial stromal tumours								0	0	0	0.00499	0	15	68									
ZNF830	91603	broad.mit.edu	37	17	33288630	33288630	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:33288630G>A	uc002hih.3	+	1	82	c.45G>A	c.(43-45)GTG>GTA	p.V15V	CCT6B_uc002hig.2_5'Flank|CCT6B_uc010ctg.2_5'Flank|CCT6B_uc010wcc.1_5'Flank	NM_052857	NP_443089	Q96NB3	ZN830_HUMAN	coiled-coil domain containing 16	15					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)	1		Ovarian(249;0.17)				GGAAGCGAGTGATAAATCAGG	0.557		NaN											0	0	0	0.003271	0	26	64									
SLFN11	91607	broad.mit.edu	37	17	33690544	33690544	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:33690544C>T	uc010ctp.2	-	4	725	c.283G>A	c.(283-285)GAG>AAG	p.E95K	SLFN11_uc010ctq.2_Missense_Mutation_p.E95K|SLFN11_uc002hjh.3_Missense_Mutation_p.E95K|SLFN11_uc002hjg.3_Missense_Mutation_p.E95K|SLFN11_uc010ctr.2_Missense_Mutation_p.E95K	NM_001104588	NP_001098058	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	95						nucleus	ATP binding			large_intestine(1)|ovary(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCTTGGTCTCAAAGAAAGCC	0.473		NaN											0	0	0	0.01441	0	56	60									
LYZL6	57151	broad.mit.edu	37	17	34264799	34264799	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:34264799C>G	uc002hkj.1	-	2	411	c.261G>C	c.(259-261)AAG>AAC	p.K87N	LYZL6_uc002hkk.1_Missense_Mutation_p.K87N	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	87					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCGAGTAACTCTTATAATCGT	0.473		NaN											0	0	0	0.003755	0	23	40									
LHX1	3975	broad.mit.edu	37	17	35297719	35297719	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:35297719C>T	uc002hnh.1	+	2	1299	c.303C>T	c.(301-303)GGC>GGT	p.G101G	LHX1_uc010cux.1_Silent_p.G9G	NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	101	LIM zinc-binding 2.				cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				TCTCCACTGGCGAGGAACTCT	0.522		NaN											0	0	0	0.001984	0	6	18									
ACACA	31	broad.mit.edu	37	17	35545234	35545234	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:35545234C>T	uc002hnm.2	-	39	4839	c.4648G>A	c.(4648-4650)GAC>AAC	p.D1550N	ACACA_uc002hnk.2_Missense_Mutation_p.D1472N|ACACA_uc002hnl.2_Missense_Mutation_p.D1492N|ACACA_uc002hnn.2_Missense_Mutation_p.D1550N|ACACA_uc002hno.2_Missense_Mutation_p.D1587N|ACACA_uc010cuy.2_Missense_Mutation_p.D244N	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1550					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GTCCTGGAGTCAGTCACTTCC	0.468		NaN											0	0	0	0.005443	0	26	29									
MRPL45	84311	broad.mit.edu	37	17	36476600	36476600	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:36476600G>A	uc002hpy.2	+	6	761	c.609G>A	c.(607-609)ATG>ATA	p.M203I		NM_032351	NP_115727	Q9BRJ2	RM45_HUMAN	mitochondrial ribosomal protein L45 precursor	203					intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome				0	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CAAGTATGATGAACCAGGGCA	0.507		NaN											0	0	0	0.01441	0	110	114									
GPR179	440435	broad.mit.edu	37	17	36486038	36486038	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:36486038C>T	uc002hpz.2	-	11	3435	c.3414G>A	c.(3412-3414)GTG>GTA	p.V1138V		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	1138	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCTGCTTACTCACCGCCTTGG	0.632		NaN											0	0	0	0.003271	0	35	42									
MED1	5469	broad.mit.edu	37	17	37576107	37576107	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:37576107C>G	uc002hrv.3	-	14	1372	c.1160G>C	c.(1159-1161)AGT>ACT	p.S387T	MED1_uc010wee.1_Missense_Mutation_p.S215T|MED1_uc002hru.2_Missense_Mutation_p.S387T	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	387	Interaction with ESR1.|Interaction with the Mediator complex.|Interaction with the Mediator complex and THRA.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TCCCTGTAGACTTCGGCCATC	0.483		NaN								HNSCC(31;0.082)			0	0	0	0.012319	0	23	68									
WIPF2	147179	broad.mit.edu	37	17	38421182	38421182	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:38421182C>A	uc002hug.1	+	5	994	c.754C>A	c.(754-756)CCT>ACT	p.P252T	WIPF2_uc002huh.1_Missense_Mutation_p.P102T|WIPF2_uc010cww.1_Missense_Mutation_p.P102T|WIPF2_uc002hui.1_Missense_Mutation_p.P252T|WIPF2_uc010cwx.1_Intron|WIPF2_uc010cwy.1_Missense_Mutation_p.P252T	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	252	Poly-Pro.					cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GGCTCCTCCTCCTCCGCCTTA	0.597		NaN								HNSCC(43;0.11)			1	0	5.34276e-22	0.01441	5.6555e-22	44	112									
KRT25	147183	broad.mit.edu	37	17	38910644	38910644	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:38910644C>G	uc002hve.2	-	2	567	c.506G>C	c.(505-507)AGA>ACA	p.R169T		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	169	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				TTACTTGAGTCTGAAATCATC	0.378		NaN											0	0	0	0.003954	0	23	54									
KRT39	390792	broad.mit.edu	37	17	39116576	39116576	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39116576C>G	uc002hvo.1	-	6	1210	c.1174G>C	c.(1174-1176)GAG>CAG	p.E392Q	KRT39_uc010wfm.1_Missense_Mutation_p.E125Q	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	392	Coil 2.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				GTGGTAATCTCACATTCCAGC	0.468		NaN											0	0	0	0.005524	0	37	90									
KRT40	125115	broad.mit.edu	37	17	39137159	39137159	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39137159C>G	uc010cxh.1	-	7	1014	c.853G>C	c.(853-855)GAA>CAA	p.E285Q	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	285	Rod.|Coil 2.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				TTCAGCTCTTCTGTCTGAAAC	0.483		NaN											0	0	0	0.01441	0	69	98									
KRTAP1-5	83895	broad.mit.edu	37	17	39183285	39183285	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39183285C>T	uc002hvu.2	-	1	170	c.123G>A	c.(121-123)CAG>CAA	p.Q41Q		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	41	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			AGAAGCTAGTCTGGCAGCTGC	0.607		NaN											0	0	0	0.008291	0	9	23									
KRTAP1-5	83895	broad.mit.edu	37	17	39183317	39183317	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39183317C>G	uc002hvu.2	-	1	138	c.91G>C	c.(91-93)GAG>CAG	p.E31Q		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	31	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			CAGCTGGTCTCACAGCAGCTT	0.597		NaN											0	0	0	0.00308	0	4	14									
KRTAP1-3	81850	broad.mit.edu	37	17	39190696	39190696	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39190696C>T	uc002hvv.2	-	1	412	c.378G>A	c.(376-378)GTG>GTA	p.V126V		NM_030966	NP_112228	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	136						extracellular region|keratin filament	structural constituent of epidermis				0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GTGTGCAGCTCACCACACAGC	0.677		NaN											0	0	0	0.004007	0	16	16									
KRT31	3881	broad.mit.edu	37	17	39551521	39551521	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39551521G>A	uc002hwn.2	-	5	905	c.852C>T	c.(850-852)ATC>ATT	p.I284I	KRT31_uc010cxn.2_Silent_p.I284I	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	284	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				CCTGCAGCTCGATCTCCAGGG	0.607		NaN											0	0	0	0.003954	0	24	80									
NT5C3L	115024	broad.mit.edu	37	17	39981850	39981850	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:39981850C>G	uc002hyc.3	-	9	939	c.930G>C	c.(928-930)GAG>GAC	p.E310D	NT5C3L_uc002hxx.3_Missense_Mutation_p.E175D|NT5C3L_uc010wfu.1_Missense_Mutation_p.E175D|NT5C3L_uc002hyb.3_Missense_Mutation_p.E233D|NT5C3L_uc002hyd.3_Missense_Mutation_p.E233D|NT5C3L_uc002hxy.3_Missense_Mutation_p.E268D|NT5C3L_uc002hxz.3_Missense_Mutation_p.E233D|NT5C3L_uc002hya.3_3'UTR	NM_052935	NP_443167	C9JKC4	C9JKC4_HUMAN	5'-nucleotidase, cytosolic III-like	276						cytoplasm	5'-nucleotidase activity|magnesium ion binding				0		Breast(137;0.000162)		BRCA - Breast invasive adenocarcinoma(366;0.15)		CATCCAGAGTCTCGTCCTTCT	0.637		NaN											0	0	0	0.01441	0	51	42									
KLHL10	317719	broad.mit.edu	37	17	40001428	40001428	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40001428G>A	uc010cxr.2	+	3	877	c.735G>A	c.(733-735)ATG>ATA	p.M245I	KLHL10_uc010wfv.1_Missense_Mutation_p.M239I|KLHL10_uc010wfw.1_Missense_Mutation_p.M157I	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	kelch-like 10	245						cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)				ATGTTAAGATGAATGACTATG	0.433		NaN											0	0	0	0.013537	0	13	42									
ACLY	47	broad.mit.edu	37	17	40069977	40069977	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40069977C>T	uc002hyg.2	-	2	313	c.150G>A	c.(148-150)CTG>CTA	p.L50L	ACLY_uc002hyh.2_Silent_p.L50L|ACLY_uc002hyi.2_Silent_p.L104L|ACLY_uc010wfx.1_Silent_p.L104L|ACLY_uc010wfy.1_Silent_p.L50L	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	50					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCTGGCTGAGCAGCCAGGGGT	0.582		NaN											0	0	0	0.00499	0	17	51									
ACLY	47	broad.mit.edu	37	17	40070105	40070105	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40070105C>T	uc002hyg.2	-	2	185	c.22G>A	c.(22-24)GAG>AAG	p.E8K	ACLY_uc002hyh.2_Missense_Mutation_p.E8K|ACLY_uc002hyi.2_Missense_Mutation_p.E62K|ACLY_uc010wfx.1_Missense_Mutation_p.E62K|ACLY_uc010wfy.1_Missense_Mutation_p.E8K	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	8					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCCGTCTGCTCTGAAATTGCC	0.547		NaN											0	0	0	0.004289	0	34	102									
KCNH4	23415	broad.mit.edu	37	17	40323937	40323937	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40323937G>A	uc002hzb.2	-	7	1397	c.1064C>T	c.(1063-1065)TCT>TTT	p.S355F		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	355	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ACTGCACTGAGAGTACCGCTC	0.527		NaN											0	0	0	0.001984	0	7	14									
STAT5B	6777	broad.mit.edu	37	17	40384031	40384031	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40384031C>G	uc002hzh.2	-	2	284	c.115G>C	c.(115-117)GAA>CAA	p.E39Q	STAT5B_uc002hzi.3_Missense_Mutation_p.E39Q	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	39					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	GCTTGGCTTTCAATCCACTGG	0.423		NaN											0	0	0	0.01441	0	50	55									
NAGLU	4669	broad.mit.edu	37	17	40689536	40689536	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40689536G>A	uc002hzv.2	+	2	844	c.504G>A	c.(502-504)TGG>TGA	p.W168*		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	168						lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CACTGGCCTGGAGCGGCCAGG	0.647		NaN											0	0	0	0.008291	0	11	35									
PLEKHH3	79990	broad.mit.edu	37	17	40828484	40828484	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:40828484C>T	uc002iau.2	-	1	565	c.98G>A	c.(97-99)GGG>GAG	p.G33E	PLEKHH3_uc002iat.1_5'Flank|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_5'UTR|PLEKHH3_uc002iaw.2_Missense_Mutation_p.G33E	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	33					signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		GTCCTCGTCCCCGTCCCCGCT	0.672		NaN											0	0	0	0.009096	0	4	9									
AARSD1	80755	broad.mit.edu	37	17	41116252	41116252	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:41116252G>A	uc002icc.2	-	2	45	c.42C>T	c.(40-42)TTC>TTT	p.F14F	AARSD1_uc002icd.2_Silent_p.F127F|AARSD1_uc002ice.2_Silent_p.F97F|AARSD1_uc002icf.2_Silent_p.F188F|AARSD1_uc010whg.1_Silent_p.F188F|AARSD1_uc010cyu.1_Silent_p.F14F	NM_025267	NP_079543	Q9BTE6	AASD1_HUMAN	alanyl-tRNA synthetase domain containing 1	14					alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CGGTGGTGGTGAACTGAACAG	0.468		NaN											0	0	0	0.001855	0	14	31									
ATXN7L3	56970	broad.mit.edu	37	17	42274334	42274334	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:42274334G>A	uc002iga.2	-	4	508	c.417C>T	c.(415-417)ATC>ATT	p.I139I	ATXN7L3_uc010wiv.1_5'Flank|ATXN7L3_uc002ifz.2_Silent_p.I139I	NM_001098833	NP_001092303	Q14CW9	AT7L3_HUMAN	ataxin 7-like 3 isoform b	139					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	SAGA complex	ligand-dependent nuclear receptor transcription coactivator activity|metal ion binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CGTTGTCATTGATGTCATCAT	0.512		NaN											0	0	0	0.01441	0	41	97									
GPATCH8	23131	broad.mit.edu	37	17	42513873	42513873	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:42513873G>C	uc002igw.1	-	4	298	c.234C>G	c.(232-234)GTC>GTG	p.V78V	GPATCH8_uc002igv.1_5'UTR|GPATCH8_uc010wiz.1_5'UTR	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	78	G-patch.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CCATGCCCATGACATCATACT	0.373		NaN											0	0	0	0.013114	0	45	60									
C17orf104	284071	broad.mit.edu	37	17	42745073	42745073	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:42745073G>C	uc010czv.2	+	5	1794	c.1794G>C	c.(1792-1794)GGG>GGC	p.G598G	C17orf104_uc002igy.1_Silent_p.G432G|C17orf104_uc002igz.3_Silent_p.G432G|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Silent_p.G432G	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	598										central_nervous_system(1)	1						AGAAGTATGGGATAATTGAAA	0.353		NaN											0	0	0	0.000602	0	5	30									
C17orf104	284071	broad.mit.edu	37	17	42745351	42745351	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:42745351G>A	uc010czv.2	+	5	2072	c.2072G>A	c.(2071-2073)AGA>AAA	p.R691K	C17orf104_uc002igy.1_Missense_Mutation_p.R525K|C17orf104_uc002igz.3_Missense_Mutation_p.R525K|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Missense_Mutation_p.R525K	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	691										central_nervous_system(1)	1						TTTCCCCTAAGATCCACCCAC	0.368		NaN											0	0	0	0.000602	0	5	27									
HEXIM1	10614	broad.mit.edu	37	17	43226866	43226866	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:43226866C>T	uc002iig.2	+	1	2183	c.309C>T	c.(307-309)TTC>TTT	p.F103F		NM_006460	NP_006451	O94992	HEXI1_HUMAN	hexamethylene bis-acetamide inducible 1	103					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			ovary(1)	1						GCGGCGACTTCCCGCCGCCGG	0.672		NaN									OREG0024474	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	5	8									
PLEKHM1	9842	broad.mit.edu	37	17	43545870	43545870	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:43545870G>A	uc002ija.2	-	5	1183	c.1013C>T	c.(1012-1014)TCG>TTG	p.S338L	PLEKHM1_uc010wjm.1_Missense_Mutation_p.S310L|PLEKHM1_uc002ijb.2_Intron|PLEKHM1_uc010wjn.1_Missense_Mutation_p.S287L	NM_014798	NP_055613	Q9Y4G2	PKHM1_HUMAN	pleckstrin homology domain containing, family M	338					intracellular signal transduction	cytoplasm	metal ion binding				0	Renal(3;0.0405)					GAGGGAGAGCGAGGCCTGTGG	0.552		NaN											0	0	0	0.00632	0	28	30									
OSBPL7	114881	broad.mit.edu	37	17	45891976	45891976	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:45891976G>A	uc002ilx.1	-	14	1465	c.1262C>T	c.(1261-1263)TCA>TTA	p.S421L	OSBPL7_uc002ilw.1_5'UTR	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	421					lipid transport		lipid binding				0						CTCCTCCTCTGAGCCCTGGGC	0.642		NaN											0	0	0	0.001168	0	6	22									
HOXB13	10481	broad.mit.edu	37	17	46805665	46805665	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:46805665C>T	uc002ioa.2	-	1	447	c.291G>A	c.(289-291)CTG>CTA	p.L97L		NM_006361	NP_006352	Q92826	HXB13_HUMAN	homeobox B13	97					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CACAGGGTTTCAGCGAGCTCC	0.672		NaN											0	0	0	0.009718	0	39	46									
SNF8	11267	broad.mit.edu	37	17	47022045	47022045	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:47022045C>T	uc002ioj.2	-	1	110	c.52G>A	c.(52-54)GAG>AAG	p.E18K	SNF8_uc002iok.2_Missense_Mutation_p.E18K	NM_007241	NP_009172	Q96H20	SNF8_HUMAN	EAP30 subunit of ELL complex	18					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding				0						CTGCTCACCTCTGCAAGTTTC	0.512		NaN											0	0	0	0.01441	0	48	132									
EPN3	55040	broad.mit.edu	37	17	48618874	48618874	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:48618874G>A	uc002ira.3	+	9	1839	c.1404G>A	c.(1402-1404)ACG>ACA	p.T468T	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Silent_p.T496T|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Silent_p.T441T	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	468						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AAAATGGCACGAAGGAGCCAG	0.582		NaN											0	0	0	0.004482	0	9	41									
WFIKKN2	124857	broad.mit.edu	37	17	48917453	48917453	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:48917453C>T	uc002isv.3	+	2	1498	c.804C>T	c.(802-804)AAC>AAT	p.N268N	WFIKKN2_uc010dbu.2_Silent_p.N175N	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	268	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			TGGTCACCAACATTGCCCAGC	0.627		NaN											0	0	0	0.00499	0	18	34									
SCPEP1	59342	broad.mit.edu	37	17	55058443	55058443	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:55058443G>A	uc002iuv.3	+	2	130	c.77G>A	c.(76-78)GGA>GAA	p.G26E	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Intron	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	26					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					TCTGTTTCAGGAGCTGTCATT	0.483		NaN											0	0	0	0.012319	0	22	15									
SCPEP1	59342	broad.mit.edu	37	17	55074400	55074400	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:55074400C>G	uc002iuv.3	+	9	917	c.864C>G	c.(862-864)TTC>TTG	p.F288L	SCPEP1_uc010dcl.2_RNA|SCPEP1_uc010wnk.1_Missense_Mutation_p.F238L	NM_021626	NP_067639	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1 precursor	288					proteolysis	extracellular region	serine-type carboxypeptidase activity			skin(1)	1	Breast(9;2.86e-08)					GTCTAGAATTCACACAGAGCC	0.363		NaN											0	0	0	0.00245	0	13	54									
MSI2	124540	broad.mit.edu	37	17	55693406	55693406	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:55693406T>C	uc002iuz.1	+	9	786	c.613T>C	c.(613-615)TAC>CAC	p.Y205H	MSI2_uc010wnm.1_Missense_Mutation_p.Y183H|MSI2_uc002iva.2_Missense_Mutation_p.Y201H	NM_138962	NP_620412	Q96DH6	MSI2H_HUMAN	musashi 2 isoform a	205						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|pancreas(1)	2	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		GGGACTGCCTTACACCATGGA	0.463		NaN	T	HOXA9	CML								0	0	0	0.00623	0	36	106									
BZRAP1	9256	broad.mit.edu	37	17	56388949	56388949	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56388949A>C	uc002ivx.3	-	18	3935	c.3064T>G	c.(3064-3066)TAC>GAC	p.Y1022D	BZRAP1_uc010dcs.2_Missense_Mutation_p.Y962D|BZRAP1_uc010wnt.1_Missense_Mutation_p.Y1022D	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1022	Fibronectin type-III 3.					mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCATCAGCGTAGATGGCATAG	0.602		NaN											0	0	0	0.00245	0	15	41									
SUPT4H1	6827	broad.mit.edu	37	17	56428800	56428800	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56428800C>T	uc002iwe.1	-	2	206	c.139G>A	c.(139-141)GAG>AAG	p.E47K	uc010dct.1_Intron|uc010dcu.1_Intron|uc002ivz.2_Intron|uc010dcv.1_Intron|uc002iwa.2_Intron|uc002iwb.2_Intron|uc002iwc.2_Intron|SUPT4H1_uc002iwd.1_RNA	NM_003168	NP_003159	P63272	SPT4H_HUMAN	suppressor of Ty 4 homolog 1	47					chromatin remodeling|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TATACCATCTCTCGGTTACCC	0.408		NaN											0	0	0	0.004656	0	26	115									
HSF5	124535	broad.mit.edu	37	17	56565211	56565211	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56565211A>C	uc002iwi.1	-	1	549	c.425T>G	c.(424-426)CTG>CGG	p.L142R		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	142	By similarity.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGGCACCTCCAGGCCGGCCGC	0.662		NaN											0	0	0	0.004672	0	2	0									
C17orf47	284083	broad.mit.edu	37	17	56620915	56620915	+	Silent	SNP	C	C	T	rs139661038		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56620915C>T	uc002iwq.1	-	1	769	c.633G>A	c.(631-633)ACG>ACA	p.T211T	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	211										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CACTAGTAGTCGTAATTCTTT	0.512		NaN											0	0	0	0.01441	0	48	140									
TEX14	56155	broad.mit.edu	37	17	56650602	56650602	+	Missense_Mutation	SNP	A	A	C	rs140397968		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:56650602A>C	uc010dcz.1	-	24	3707	c.3589T>G	c.(3589-3591)TCA>GCA	p.S1197A	TEX14_uc002iwr.1_Missense_Mutation_p.S1191A|TEX14_uc002iws.1_Missense_Mutation_p.S1151A|TEX14_uc010dda.1_Missense_Mutation_p.S931A	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	1197						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTTTTGCATGAAGCTTCCTTA	0.428		NaN											0	0	0	0.01441	0	60	214									
BCAS3	54828	broad.mit.edu	37	17	59067592	59067592	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:59067592G>A	uc002iyv.3	+	15	1591	c.1482G>A	c.(1480-1482)TTG>TTA	p.L494L	BCAS3_uc010wow.1_Silent_p.L281L|BCAS3_uc002iyu.3_Silent_p.L494L|BCAS3_uc002iyw.3_Silent_p.L490L|BCAS3_uc002iyx.1_Silent_p.L309L|BCAS3_uc002iyy.3_Silent_p.L265L|BCAS3_uc002iyz.3_Silent_p.L48L|BCAS3_uc002iza.3_Silent_p.L48L	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	494						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			GGTCACCCTTGCATGGTAATT	0.438		NaN											0	0	0	0.014323	0	21	52									
MED13	9969	broad.mit.edu	37	17	60088352	60088352	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:60088352G>A	uc002izo.2	-	9	1603	c.1526C>T	c.(1525-1527)TCA>TTA	p.S509L	MED13_uc002izp.2_Missense_Mutation_p.S125L	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	509					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCGGATATTTGAAAATCTCAC	0.463		NaN											0	0	0	0.00632	0	26	86									
LRRC37A3	374819	broad.mit.edu	37	17	62892235	62892235	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:62892235C>T	uc002jey.2	-	3	1672	c.1141G>A	c.(1141-1143)GAG>AAG	p.E381K	LRRC37A3_uc010wqg.1_Intron|LRRC37A3_uc010wqf.1_Intron	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	381	Extracellular (Potential).					integral to membrane					0						CCTGGGGTCTCCTGCTGGGTC	0.517		NaN											0	0	0	0.01441	0	82	153									
SLC16A6	9120	broad.mit.edu	37	17	66267782	66267782	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:66267782C>T	uc002jgz.1	-	5	707	c.519G>A	c.(517-519)CTG>CTA	p.L173L	ARSG_uc002jhc.2_Intron|SLC16A6_uc002jha.1_Silent_p.L173L	NM_004694	NP_004685	O15403	MOT7_HUMAN	solute carrier family 16, member 6	173	Extracellular (Potential).					integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity				0	all_cancers(12;1.24e-09)		BRCA - Breast invasive adenocarcinoma(8;3.17e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)		Pyruvic acid(DB00119)	TGCGCTCCTTCAGAGCCATGA	0.448		NaN											0	0	0	0.008361	0	25	24									
ABCA10	10349	broad.mit.edu	37	17	67149526	67149526	+	Silent	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:67149526C>A	uc010dfa.1	-	35	4935	c.4056G>T	c.(4054-4056)CTG>CTT	p.L1352L	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Silent_p.L344L|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1352	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CCAGGATGCTCAGCACAAAGC	0.562		NaN											1	0	4.11147e-13	0.003755	4.30386e-13	36	110									
ABCA10	10349	broad.mit.edu	37	17	67170479	67170479	+	Silent	SNP	T	T	C	rs143503638	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:67170479T>C	uc010dfa.1	-	26	3984	c.3105A>G	c.(3103-3105)TCA>TCG	p.S1035S	ABCA10_uc010wqs.1_Silent_p.S27S|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1035					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAAAGATGAATGAAAGCACAT	0.338		NaN											0	0	0	0.003755	0	32	130									
SOX9	6662	broad.mit.edu	37	17	70119040	70119040	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:70119040C>T	uc002jiw.2	+	2	984	c.612C>T	c.(610-612)TTC>TTT	p.F204F	uc002jiv.2_5'Flank	NM_000346	NP_000337	P48436	SOX9_HUMAN	transcription factor SOX9	204					cAMP-mediated signaling|negative regulation of transcription, DNA-dependent|positive regulation of branching involved in ureteric bud morphogenesis|protein complex assembly|renal vesicle induction	nucleus|protein complex	core promoter sequence-specific DNA binding|enhancer binding|protein kinase A catalytic subunit binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription				0		Colorectal(1115;0.245)	STAD - Stomach adenocarcinoma(260;0.119)			ACGCCATCTTCAAGGCGCTGC	0.677		NaN											0	0	0	0.00623	0	35	39									
ICT1	3396	broad.mit.edu	37	17	73016661	73016661	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:73016661G>A	uc002jmm.2	+	5	447	c.445G>A	c.(445-447)GAT>AAT	p.D149N		NM_001545	NP_001536	Q14197	ICT1_HUMAN	immature colon carcinoma transcript 1 precursor	149					mitochondrial translational termination	mitochondrial large ribosomal subunit	aminoacyl-tRNA hydrolase activity|translation release factor activity, codon nonspecific			ovary(1)|central_nervous_system(1)	2	all_lung(278;0.226)					GAATCTGGCAGATTGCCTGCA	0.453		NaN											0	0	0	0.004007	0	14	41									
SRP68	6730	broad.mit.edu	37	17	74053483	74053483	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:74053483C>T	uc002jqk.1	-	8	1013	c.978_splice	c.e8+1	p.Q326_splice	SRP68_uc010wsu.1_Splice_Site_p.Q225_splice|SRP68_uc002jql.1_Splice_Site_p.Q288_splice	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa						response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						TTCCTCCTCACCTGGACAATA	0.448		NaN											0	0	0	0.010504	0	20	43									
CBX2	84733	broad.mit.edu	37	17	77758613	77758613	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:77758613G>A	uc002jxc.2	+	5	1413	c.1371G>A	c.(1369-1371)GAG>GAA	p.E457E		NM_005189	NP_005180	Q14781	CBX2_HUMAN	chromobox homolog 2 isoform 1	457					cell differentiation|chromatin modification|development of primary sexual characteristics|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex	DNA binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CACTGCCAGAGATGAGCGCAG	0.672		NaN											0	0	0	0.001168	0	4	8									
CBX8	57332	broad.mit.edu	37	17	77770064	77770064	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:77770064G>A	uc002jxd.1	-	3	257	c.164C>T	c.(163-165)GCA>GTA	p.A55V		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	55	Chromo.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CTCAAAGGCTGCGAGCAAGCG	0.532		NaN											0	0	0	0.01441	0	118	106									
CCDC40	55036	broad.mit.edu	37	17	78039319	78039319	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:78039319G>C	uc010dht.2	+	10	1503	c.1476G>C	c.(1474-1476)AAG>AAC	p.K492N	CCDC40_uc010wub.1_Intron|CCDC40_uc002jxm.3_Missense_Mutation_p.K275N	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	492					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCGTGGAGAAGAGGCGCATCA	0.632		NaN											0	0	0	0.001855	0	14	54									
ACTG1	71	broad.mit.edu	37	17	79478272	79478272	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:79478272G>A	uc002kaj.1	-	3	769	c.744C>T	c.(742-744)ATC>ATT	p.I248I	ACTG1_uc002kah.1_Silent_p.I126I|ACTG1_uc002kai.1_Silent_p.I205I|ACTG1_uc002kak.1_Silent_p.I248I|ACTG1_uc010wun.1_Silent_p.I248I|ACTG1_uc002kal.1_Silent_p.I248I|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	248					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			TGCCAATGGTGATGACCTGGC	0.587		NaN											0	0	0	0.01441	0	50	75									
FSCN2	25794	broad.mit.edu	37	17	79503670	79503670	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:79503670C>G	uc010wup.1	+	4	1269	c.1128C>G	c.(1126-1128)CTC>CTG	p.L376L	FSCN2_uc010wuo.1_Silent_p.L400L	NM_012418	NP_036550	O14926	FSCN2_HUMAN	fascin 2 isoform 1	376					actin filament bundle assembly|anatomical structure morphogenesis|visual perception	actin cytoskeleton|cytoplasm|stereocilium	actin filament binding|protein binding, bridging				0	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			AGTTCACCCTCAAGCTCATCA	0.701		NaN											0	0	0	0.000602	0	2	2									
P4HB	5034	broad.mit.edu	37	17	79803467	79803467	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:79803467G>A	uc002kbn.1	-	9	1526	c.1329C>T	c.(1327-1329)CTC>CTT	p.L443L	P4HB_uc002kbl.1_Silent_p.L120L|P4HB_uc002kbm.1_Silent_p.L120L	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	443	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GAAAGAACTTGAGTGTGGGGA	0.622		NaN											0	0	0	0.010729	0	11	11									
DUS1L	64118	broad.mit.edu	37	17	80018633	80018633	+	Silent	SNP	C	C	T	rs150777513		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80018633C>T	uc002kdq.2	-	9	1385	c.966G>A	c.(964-966)GCG>GCA	p.A322A	DUS1L_uc002kdp.2_Silent_p.A191A|DUS1L_uc002kdr.2_Silent_p.A322A|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	322					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CGGTGGGCTTCGCTCCCTCCT	0.687		NaN											0	0	0	0.000602	0	5	11									
DUS1L	64118	broad.mit.edu	37	17	80018637	80018637	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80018637C>T	uc002kdq.2	-	9	1381	c.962G>A	c.(961-963)GGA>GAA	p.G321E	DUS1L_uc002kdp.2_Missense_Mutation_p.G190E|DUS1L_uc002kdr.2_Missense_Mutation_p.G321E|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	321					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GGGCTTCGCTCCCTCCTGCCT	0.692		NaN											0	0	0	0.000602	0	5	10									
DUS1L	64118	broad.mit.edu	37	17	80019230	80019230	+	Splice_Site	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80019230C>G	uc002kdq.2	-	7	1117	c.698_splice	c.e7-1	p.E233_splice	DUS1L_uc002kdp.2_Splice_Site_p.E102_splice|DUS1L_uc002kdr.2_Splice_Site_p.E233_splice|DUS1L_uc002kds.2_Splice_Site|DUS1L_uc002kdt.2_Splice_Site|DUS1L_uc010wvi.1_Intron	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein						tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			AGGTTGCCCTCTGTGGGAGGA	0.667		NaN											0	0	0	0.001168	0	5	24									
WDR45L	56270	broad.mit.edu	37	17	80574488	80574488	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80574488G>A	uc002kfq.2	-	9	1035	c.840C>T	c.(838-840)TTC>TTT	p.F280F	WDR45L_uc002kfr.2_RNA	NM_019613	NP_062559	Q5MNZ6	WIPI3_HUMAN	WDR45-like	280					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)			ACTTGGAACTGAAGTATTTTG	0.463		NaN											0	0	0	0.005443	0	27	88									
LPIN2	9663	broad.mit.edu	37	18	2920390	2920390	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:2920390G>A	uc002klo.2	-	20	2831	c.2592C>T	c.(2590-2592)CTC>CTT	p.L864L		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	864					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GCTCCTTACTGAGAAGGGGGA	0.537		NaN											0	0	0	0.007413	0	17	28									
DLGAP1	9229	broad.mit.edu	37	18	3814113	3814113	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:3814113C>T	uc002kmf.2	-	2	1185	c.1118G>A	c.(1117-1119)AGA>AAA	p.R373K	DLGAP1_uc010wyz.1_Missense_Mutation_p.R373K|DLGAP1_uc002kme.1_Missense_Mutation_p.R71K|DLGAP1_uc010dkn.2_Missense_Mutation_p.R71K|DLGAP1_uc010wyw.1_Missense_Mutation_p.R79K|DLGAP1_uc010wyx.1_Missense_Mutation_p.R85K|DLGAP1_uc010wyy.1_Missense_Mutation_p.R85K|DLGAP1_uc002kmg.2_Missense_Mutation_p.R71K|DLGAP1_uc002kmk.2_Missense_Mutation_p.R373K	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	373					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				ATAGCTTTCTCTCCGCGCAGC	0.507		NaN											0	0	0	0.01441	0	51	33									
KIAA0802	23255	broad.mit.edu	37	18	8824703	8824703	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:8824703G>A	uc002knr.2	+	15	3337	c.3195G>A	c.(3193-3195)GTG>GTA	p.V1065V	KIAA0802_uc002knq.2_Silent_p.V1024V|KIAA0802_uc002kns.2_Silent_p.V405V	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1375											0						CCAGGGCGGTGTCCGTGTCCT	0.587		NaN											0	0	0	0.003163	0	15	8									
RALBP1	10928	broad.mit.edu	37	18	9522255	9522255	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:9522255G>A	uc002kob.2	+	4	1024	c.801G>A	c.(799-801)CTG>CTA	p.L267L	RALBP1_uc002koc.2_Silent_p.L267L	NM_006788	NP_006779	Q15311	RBP1_HUMAN	ralA binding protein 1	267	Rho-GAP.				chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			central_nervous_system(1)	1						CCAGTTTGCTGAAGCAGTATT	0.463		NaN											0	0	0	0.00499	0	16	53									
RBBP8	5932	broad.mit.edu	37	18	20606179	20606179	+	Silent	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:20606179A>C	uc002ktw.2	+	19	3001	c.2670A>C	c.(2668-2670)CCA>CCC	p.P890P	RBBP8_uc002kty.2_Silent_p.P890P|RBBP8_uc002ktz.2_Missense_Mutation_p.Q858P|RBBP8_uc002kua.2_Silent_p.P895P|RBBP8_uc010xap.1_Silent_p.P228P	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	890					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			TATTTTCTCCAAAAGGCAAGG	0.348		NaN						Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.012213	0	30	21									
NPC1	4864	broad.mit.edu	37	18	21148935	21148935	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:21148935C>T	uc002kum.3	-	4	589	c.315G>A	c.(313-315)CTG>CTA	p.L105L	NPC1_uc010xba.1_5'UTR	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	105					autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAAACAGGTTCAGTAGGTTAT	0.368		NaN											0	0	0	0.007413	0	20	50									
LAMA3	3909	broad.mit.edu	37	18	21479265	21479265	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:21479265G>C	uc002kuq.2	+	47	5936	c.5850G>C	c.(5848-5850)CAG>CAC	p.Q1950H	LAMA3_uc002kur.2_Intron|LAMA3_uc002kus.3_Missense_Mutation_p.Q341H|LAMA3_uc002kut.3_Intron	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1950	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTTTAAAGCAGATCTCTGGGA	0.458		NaN											0	0	0	0.013537	0	11	30									
TAF4B	6875	broad.mit.edu	37	18	23866219	23866219	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:23866219C>T	uc002kvu.3	+	7	1835	c.1346C>T	c.(1345-1347)TCA>TTA	p.S449L	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Missense_Mutation_p.S449L	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	449					transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			ACCACGGTCTCACTGCAACCT	0.488		NaN											0	0	0	0.00333	0	25	37									
TTR	7276	broad.mit.edu	37	18	29171903	29171903	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:29171903G>A	uc002kwx.3	+	1	174	c.38G>A	c.(37-39)GGA>GAA	p.G13E		NM_000371	NP_000362	P02766	TTHY_HUMAN	transthyretin precursor	13					transport	cytoplasm	hormone activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(10;0.00523)		Diclofenac(DB00586)|Diethylstilbestrol(DB00255)|Diflunisal(DB00861)|Dimethyl sulfoxide(DB01093)|Levothyroxine(DB00451)|Liothyronine(DB00279)	TGCCTTGCTGGACTGGTATTT	0.493		NaN											0	0	0	0.006122	0	17	31									
KIAA1012	22878	broad.mit.edu	37	18	29419348	29419348	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:29419348C>T	uc002kxc.3	-	27	4274	c.3910G>A	c.(3910-3912)GAG>AAG	p.E1304K	KIAA1012_uc002kxb.3_Missense_Mutation_p.E1250K|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1304					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						GAAAGCTGCTCTACTGATGGC	0.348		NaN											0	0	0	0.004656	0	27	56									
RNF125	54941	broad.mit.edu	37	18	29617112	29617112	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:29617112G>A	uc002kxf.1	+	2	580	c.198G>A	c.(196-198)AAG>AAA	p.K66K		NM_017831	NP_060301	Q96EQ8	RN125_HUMAN	ring finger protein 125	66	RING-type.				negative regulation of type I interferon production	intracellular	ligase activity|zinc ion binding				0						CCAGTCTAAAGAACAACAAGT	0.423		NaN											0	0	0	0.01441	0	83	147									
NOL4	8715	broad.mit.edu	37	18	31523073	31523073	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:31523073C>T	uc010dmi.2	-	9	1727	c.1498G>A	c.(1498-1500)GAG>AAG	p.E500K	NOL4_uc010xbs.1_Missense_Mutation_p.E215K|NOL4_uc002kxr.3_Missense_Mutation_p.E272K|NOL4_uc010xbt.1_Missense_Mutation_p.E426K|NOL4_uc010dmh.2_Missense_Mutation_p.E362K|NOL4_uc010xbu.1_Missense_Mutation_p.E436K|NOL4_uc002kxt.3_Intron|NOL4_uc010xbv.1_Missense_Mutation_p.E185K	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	500						nucleolus	RNA binding			ovary(3)	3						TTTCTACTCTCACTCTCACAA	0.428		NaN											0	0	0	0.010504	0	21	32									
DTNA	1837	broad.mit.edu	37	18	32391936	32391936	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:32391936G>A	uc010dmn.1	+	5	463	c.462G>A	c.(460-462)ATG>ATA	p.M154I	DTNA_uc002kxu.2_Missense_Mutation_p.M154I|DTNA_uc010xbx.1_Missense_Mutation_p.M154I|DTNA_uc002kxv.3_Missense_Mutation_p.M154I|DTNA_uc002kxw.2_Missense_Mutation_p.M154I|DTNA_uc002kxx.2_Missense_Mutation_p.M154I|DTNA_uc010dmj.2_Missense_Mutation_p.M154I|DTNA_uc002kxz.2_Missense_Mutation_p.M154I|DTNA_uc002kxy.2_Missense_Mutation_p.M154I|DTNA_uc010dmk.1_RNA|DTNA_uc010dml.2_Missense_Mutation_p.M154I|DTNA_uc002kyb.3_Missense_Mutation_p.M154I|DTNA_uc010dmm.2_Missense_Mutation_p.M154I	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	154	Interaction with MAGEE1 (By similarity).				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						TTTTCTCAATGATTTCTGACT	0.368		NaN											0	0	0	0.00333	0	21	43									
ELP2	55250	broad.mit.edu	37	18	33722249	33722249	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:33722249G>C	uc002kzk.1	+	7	604	c.594G>C	c.(592-594)CAG>CAC	p.Q198H	ELP2_uc010xcg.1_Missense_Mutation_p.Q263H|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.Q172H|ELP2_uc010xch.1_Missense_Mutation_p.Q237H|ELP2_uc002kzn.1_Missense_Mutation_p.Q172H|ELP2_uc002kzo.1_Intron	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	198	WD 4.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						ACTAGTTTCAGAAAGTGCTTT	0.398		NaN											0	0	0	0.008361	0	30	60									
ELP2	55250	broad.mit.edu	37	18	33722792	33722792	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:33722792G>C	uc002kzk.1	+	8	669	c.659G>C	c.(658-660)AGA>ACA	p.R220T	ELP2_uc010xcg.1_Missense_Mutation_p.R285T|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.R194T|ELP2_uc010xch.1_Missense_Mutation_p.R259T|ELP2_uc002kzn.1_Missense_Mutation_p.R194T|ELP2_uc002kzo.1_Missense_Mutation_p.R150T	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	220	WD 5.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						TAATTAGGTAGAGATCTTTTC	0.264		NaN											0	0	0	0.003954	0	23	45									
PSTPIP2	9050	broad.mit.edu	37	18	43571884	43571884	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:43571884C>T	uc002lbp.3	-	12	1000	c.904G>A	c.(904-906)GGG>AGG	p.G302R	PSTPIP2_uc002lbq.3_Silent_p.Q269Q	NM_024430	NP_077748	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting	302						membrane				ovary(1)	1						AAGTTAGGCCCTGTAGCCTTT	0.408		NaN											0	0	0	0.004007	0	17	28									
ATP8B1	5205	broad.mit.edu	37	18	55362485	55362485	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:55362485A>C	uc002lgw.2	-	9	858	c.858T>G	c.(856-858)TTT>TTG	p.F286L	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	286	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				CATCCAAAGGAAAACTTGTGT	0.343		NaN							Byler_disease				0	0	0	0.012319	0	20	47									
ATP8B1	5205	broad.mit.edu	37	18	55368508	55368508	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:55368508G>A	uc002lgw.2	-	4	431	c.431C>T	c.(430-432)ACA>ATA	p.T144I	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	144	Helical; (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GGGCACTAGTGTGGTGTACCA	0.463		NaN							Byler_disease				0	0	0	0.013537	0	12	27									
BCL2	596	broad.mit.edu	37	18	60985642	60985642	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:60985642G>A	uc002lit.1	-	2	751	c.258C>T	c.(256-258)CTC>CTT	p.L86L	BCL2_uc002liu.1_Silent_p.L86L|BCL2_uc002liv.1_Silent_p.L86L	NM_000633	NP_000624	P10415	BCL2_HUMAN	B-cell lymphoma protein 2 alpha isoform	86					activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)	1		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	GCACCGGGCTGAGCGCAggcc	0.622		NaN	T	IGH@	NHL|CLL								0	0	0	0.004672	0	3	6									
SERPINB8	5271	broad.mit.edu	37	18	61647081	61647081	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:61647081C>T	uc002ljv.2	+	3	384	c.215C>T	c.(214-216)TCA>TTA	p.S72L	SERPINB8_uc002ljs.1_Missense_Mutation_p.S72L|SERPINB8_uc002ljt.2_Missense_Mutation_p.S72L|SERPINB8_uc002lju.2_Missense_Mutation_p.S72L|SERPINB8_uc010xex.1_5'UTR	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	72					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				GGTTTCCAGTCACTTCTCAGT	0.428		NaN									OREG0025042	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004289	0	38	70									
RTTN	25914	broad.mit.edu	37	18	67715352	67715352	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:67715352G>A	uc002lkp.2	-	40	5464	c.5396C>T	c.(5395-5397)TCT>TTT	p.S1799F	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.S887F|RTTN_uc010dqp.2_Missense_Mutation_p.S51F	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1799							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CAAGAGAACAGAAAGGAATTG	0.448		NaN											0	0	0	0.008871	0	20	29									
CNDP2	55748	broad.mit.edu	37	18	72167257	72167257	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:72167257C>T	uc002llm.1	+	2	211	c.49C>T	c.(49-51)CGC>TGC	p.R17C	CNDP2_uc002lln.1_Missense_Mutation_p.R17C|CNDP2_uc002llo.2_Missense_Mutation_p.R17C	NM_018235	NP_060705	Q96KP4	CNDP2_HUMAN	CNDP dipeptidase 2	17						cytoplasm	carboxypeptidase activity|metal ion binding|metallopeptidase activity|protein binding|tripeptidase activity			ovary(2)|skin(1)	3		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.22)		AAATCAGGATCGCTACATTAA	0.428		NaN											0	0	0	0.013537	0	12	19									
NFATC1	4772	broad.mit.edu	37	18	77211716	77211716	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:77211716G>A	uc010xfg.1	+	6	2256	c.1803G>A	c.(1801-1803)CAG>CAA	p.Q601Q	NFATC1_uc002lnc.1_Silent_p.Q601Q|NFATC1_uc010xff.1_Missense_Mutation_p.R573K|NFATC1_uc002lnd.2_Silent_p.Q601Q|NFATC1_uc002lne.2_Silent_p.Q129Q|NFATC1_uc010xfh.1_Silent_p.Q601Q|NFATC1_uc010xfi.1_Silent_p.Q588Q|NFATC1_uc010xfj.1_Silent_p.Q129Q|NFATC1_uc002lnf.2_Silent_p.Q588Q|NFATC1_uc002lng.2_Silent_p.Q588Q|NFATC1_uc010xfk.1_Silent_p.Q588Q	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	601					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		TGGAGAAGCAGAGCACGGACA	0.627		NaN											0	0	0	0.001855	0	13	21									
POLRMT	5442	broad.mit.edu	37	19	622259	622259	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:622259C>T	uc002lpf.1	-	9	1797	c.1741G>A	c.(1741-1743)GAG>AAG	p.E581K		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	581					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCAGCATCTCCGCCAGCAGC	0.672		NaN											0	0	0	0.009096	0	2	0									
POLR2E	5434	broad.mit.edu	37	19	1093966	1093966	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:1093966C>T	uc002lre.3	-	2	246	c.169G>A	c.(169-171)GAC>AAC	p.D57N	POLR2E_uc010xgf.1_Intron	NM_002695	NP_002686	P19388	RPAB1_HUMAN	DNA directed RNA polymerase II polypeptide E	57					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGGTGAGGTCCGTGCGCCGC	0.642		NaN											0	0	0	0.000602	0	5	13									
APC2	10297	broad.mit.edu	37	19	1453566	1453566	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:1453566G>A	uc002lsr.1	+	4	577	c.369G>A	c.(367-369)CTG>CTA	p.L123L	APC2_uc002lss.1_5'UTR|APC2_uc002lst.1_Silent_p.L123L|APC2_uc002lsu.1_Silent_p.L123L	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	123					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGGGGAGCTGAGCCGGGCCA	0.721		NaN											0	0	0	0.00308	0	8	14									
APC2	10297	broad.mit.edu	37	19	1461114	1461114	+	Missense_Mutation	SNP	G	G	T	rs146990856		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:1461114G>T	uc002lsr.1	+	13	1808	c.1600G>T	c.(1600-1602)GTG>TTG	p.V534L	APC2_uc002lss.1_Missense_Mutation_p.V116L|APC2_uc002lst.1_Missense_Mutation_p.V534L|APC2_uc002lsu.1_Missense_Mutation_p.V533L|uc002lsv.2_5'Flank	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	534	ARM 3.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGGGCAGCGTGACTGCCCT	0.647		NaN											1	0	0.000132079	0.008871	0.000134622	18	57									
ATP8B3	148229	broad.mit.edu	37	19	1785654	1785654	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:1785654C>G	uc002ltw.2	-	26	3441	c.3207G>C	c.(3205-3207)CAG>CAC	p.Q1069H	ATP8B3_uc002ltv.2_Missense_Mutation_p.Q1032H|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1069	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCGTCCTTCTGCCCCACCA	0.607		NaN											0	0	0	0.013537	0	12	8									
DOT1L	84444	broad.mit.edu	37	19	2194543	2194543	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:2194543G>A	uc002lvb.3	+	7	654	c.618G>A	c.(616-618)ATG>ATA	p.M206I		NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	206						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGTGGATGAAATGGTATG	0.313		NaN											0	0	0	0.007413	0	17	40									
DOT1L	84444	broad.mit.edu	37	19	2208972	2208972	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:2208972C>T	uc002lvb.3	+	12	1038	c.1002C>T	c.(1000-1002)CTC>CTT	p.L334L	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	334						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCAAAACTCAGGGTAAGTT	0.443		NaN											0	0	0	0.004656	0	26	48									
ZNF555	148254	broad.mit.edu	37	19	2852793	2852793	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:2852793A>G	uc002lwo.2	+	4	819	c.730A>G	c.(730-732)ACT>GCT	p.T244A	ZNF555_uc002lwn.3_Missense_Mutation_p.T243A	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	244	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCAAGTCTTACTAGTCATCT	0.423		NaN											0	0	0	0.006122	0	19	54									
AES	166	broad.mit.edu	37	19	3055693	3055693	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:3055693C>G	uc002lwy.1	-	5	439	c.266G>C	c.(265-267)TGT>TCT	p.C89S	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Missense_Mutation_p.C89S|AES_uc002lxa.1_Missense_Mutation_p.C33S|AES_uc002lxb.1_Missense_Mutation_p.C156S|AES_uc002lxc.2_Missense_Mutation_p.C156S	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	89	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACCTGGGCACAAATCCCGTT	0.642		NaN											0	0	0	0.001855	0	12	27									
GIPC3	126326	broad.mit.edu	37	19	3586625	3586625	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:3586625G>A	uc002lyd.3	+	2	385	c.358G>A	c.(358-360)GAT>AAT	p.D120N		NM_133261	NP_573568	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	120	PDZ.									breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		TAAGACAGAGGATGCTCTGGG	0.632		NaN									OREG0025154	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	18	92									
DAPK3	1613	broad.mit.edu	37	19	3964647	3964647	+	Silent	SNP	G	G	A	rs144975421	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:3964647G>A	uc002lzc.1	-	2	498	c.405C>T	c.(403-405)ATC>ATT	p.I135I	DAPK3_uc002lzb.1_5'Flank|DAPK3_uc002lzd.1_Silent_p.I135I	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	135	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAAGTGTGCGATGCGCTTAG	0.642		NaN											0	0	0	0.014323	0	20	59									
CREB3L3	84699	broad.mit.edu	37	19	4164618	4164618	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:4164618C>T	uc002lzl.2	+	5	811	c.695C>T	c.(694-696)ACT>ATT	p.T232I	CREB3L3_uc002lzm.2_Missense_Mutation_p.T222I|CREB3L3_uc010xib.1_Missense_Mutation_p.T221I|CREB3L3_uc010xic.1_Missense_Mutation_p.T223I	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	232	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCTGCCCACTCAGCTGCCC	0.582		NaN											0	0	0	0.008871	0	20	26									
SHD	56961	broad.mit.edu	37	19	4288274	4288274	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:4288274G>A	uc002lzw.2	+	5	2214	c.751G>A	c.(751-753)GAG>AAG	p.E251K	SHD_uc010dtu.2_Intron	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	251	SH2.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGGATGCAGAGAGCCTCCT	0.557		NaN											0	0	0	0.004007	0	16	42									
SHD	56961	broad.mit.edu	37	19	4288325	4288325	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:4288325G>A	uc002lzw.2	+	5	2265	c.802G>A	c.(802-804)GAG>AAG	p.E268K	SHD_uc010dtu.2_Intron	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	268	SH2.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGCTCAGTGAGACCAACCC	0.572		NaN											0	0	0	0.004482	0	8	26									
ACSBG2	81616	broad.mit.edu	37	19	6187358	6187358	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6187358G>A	uc002mef.1	+	12	1832	c.1605G>A	c.(1603-1605)AAG>AAA	p.K535K	ACSBG2_uc002mee.1_Silent_p.K348K|ACSBG2_uc002meg.1_Silent_p.K535K|ACSBG2_uc002meh.1_Silent_p.K535K|ACSBG2_uc002mei.1_Silent_p.K485K|ACSBG2_uc010xiz.1_Silent_p.K535K	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	535					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						TGGTTAAGAAGAAGATCCCCA	0.468		NaN											0	0	0	0.00333	0	19	80									
ACER1	125981	broad.mit.edu	37	19	6306799	6306799	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6306799G>A	uc002mel.2	-	6	799	c.721C>T	c.(721-723)CGC>TGC	p.R241C		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	241	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						GGCCAGTAGCGGACTTTGAGG	0.572		NaN											0	0	0	0.008291	0	11	37									
CLPP	8192	broad.mit.edu	37	19	6364487	6364487	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6364487C>T	uc002mem.1	+	4	515	c.392C>T	c.(391-393)GCC>GTC	p.A131V	CLPP_uc002men.1_5'Flank	NM_006012	NP_006003	Q16740	CLPP_HUMAN	caseinolytic peptidase, ATP-dependent,	131					proteolysis	mitochondrial matrix	ATP binding|protein binding|serine-type endopeptidase activity			ovary(1)	1						GCGGGCCTGGCCATCTACGAC	0.667		NaN											0	0	0	0.000602	0	4	9									
TRIP10	9322	broad.mit.edu	37	19	6746547	6746547	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6746547G>C	uc002mfs.2	+	11	1303	c.1237G>C	c.(1237-1239)GAA>CAA	p.E413Q	TRIP10_uc010dux.1_Missense_Mutation_p.E357Q|TRIP10_uc002mfr.2_Missense_Mutation_p.E357Q|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Missense_Mutation_p.E176Q	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	413	Interaction with CDC42.|Interaction with PDE6G (By similarity).|REM.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						ACGCAGTCGTGAACTTCAGAA	0.478		NaN											0	0	0	0.001984	0	7	14									
VAV1	7409	broad.mit.edu	37	19	6829860	6829860	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:6829860C>T	uc002mfu.1	+	14	1426	c.1329C>T	c.(1327-1329)CTC>CTT	p.L443L	VAV1_uc010xjh.1_Silent_p.L411L|VAV1_uc010dva.1_Silent_p.L443L|VAV1_uc002mfv.1_Silent_p.L388L	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	443	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CCTATGACCTCAAGGACTTTG	0.532		NaN											0	0	0	0.00333	0	23	86									
INSR	3643	broad.mit.edu	37	19	7152923	7152923	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:7152923G>A	uc002mgd.1	-	10	2154	c.2045C>T	c.(2044-2046)TCG>TTG	p.S682L	INSR_uc002mge.1_Missense_Mutation_p.S682L|INSR_uc002mgf.2_Missense_Mutation_p.S682L	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	682	Fibronectin type-III 1.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCAGGTCCTCGAGGGCAGCTT	0.438		NaN											0	0	0	0.014323	0	22	49									
INSR	3643	broad.mit.edu	37	19	7184523	7184523	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:7184523G>A	uc002mgd.1	-	3	887	c.778C>T	c.(778-780)CTG>TTG	p.L260L	INSR_uc002mge.1_Silent_p.L260L|INSR_uc002mgf.2_Silent_p.L260L	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	260	Cys-rich.		L -> P (in LEPRCH; Geldeimalsen).		activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGCCGTCCAGGTAGAAGTTG	0.637		NaN											0	0	0	0.009096	0	3	13									
ARHGEF18	23370	broad.mit.edu	37	19	7531822	7531822	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:7531822G>A	uc002mgi.2	+	14	2612	c.2359G>A	c.(2359-2361)GAA>AAA	p.E787K	ARHGEF18_uc010xjm.1_Missense_Mutation_p.E629K|ARHGEF18_uc002mgh.2_Missense_Mutation_p.E629K|ARHGEF18_uc002mgj.1_Missense_Mutation_p.E430K	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	787					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				GCCAGGCACGGAATCCGATCC	0.632		NaN											0	0	0	0.008291	0	10	57									
C19orf59	199675	broad.mit.edu	37	19	7743014	7743014	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:7743014C>G	uc002mhh.1	+	3	234	c.209C>G	c.(208-210)TCA>TGA	p.S70*	TRAPPC5_uc002mhi.1_5'Flank|TRAPPC5_uc002mhj.1_5'Flank|TRAPPC5_uc002mhk.1_5'Flank	NM_174918	NP_777578	Q8IX19	MCEM1_HUMAN	mast cell-expressed membrane protein 1	70	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						AGGCCGCCCTCAGACTCCACC	0.597		NaN									OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	44	137									
OR7D4	125958	broad.mit.edu	37	19	9325375	9325375	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:9325375G>C	uc002mla.1	-	1	139	c.139C>G	c.(139-141)CTG>GTG	p.L47V		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	47	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CTGACGGCCAGAATGATGAGC	0.557		NaN											0	0	0	0.00245	0	14	56									
ZNF121	7675	broad.mit.edu	37	19	9677729	9677729	+	Silent	SNP	G	G	A	rs149905678		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:9677729G>A	uc010xkp.1	-	4	292	c.60C>T	c.(58-60)TTC>TTT	p.F20F	ZNF121_uc010dwt.2_Silent_p.F20F|ZNF121_uc010xkq.1_Silent_p.F20F	NM_001008727	NP_001008727	P58317	ZN121_HUMAN	zinc finger protein 121	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTGTTCACTGAAGATTTCTC	0.383		NaN											0	0	0	0.014323	0	22	58									
ZNF562	54811	broad.mit.edu	37	19	9763894	9763894	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:9763894G>C	uc010xks.1	-	6	1175	c.1012C>G	c.(1012-1014)CAC>GAC	p.H338D	ZNF562_uc002mly.2_Missense_Mutation_p.H338D|ZNF562_uc002mlx.2_Missense_Mutation_p.H266D|ZNF562_uc010xkt.1_Missense_Mutation_p.H301D|ZNF562_uc010xku.1_Missense_Mutation_p.H269D|ZNF562_uc010xkv.1_Missense_Mutation_p.H337D|ZNF562_uc010xkw.1_Missense_Mutation_p.H222D	NM_001130032	NP_001123504	Q6V9R5	ZN562_HUMAN	zinc finger protein 562 isoform a	338	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTCCAGTGTGAGTTCTTACA	0.418		NaN											0	0	0	0.005524	0	37	127									
TYK2	7297	broad.mit.edu	37	19	10488945	10488945	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10488945G>A	uc002moc.3	-	3	516	c.138C>T	c.(136-138)TTC>TTT	p.F46F	TYK2_uc010dxe.2_Intron|TYK2_uc002mod.2_Silent_p.F46F	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	46	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ATGACTCACTGAAAGTGACCC	0.622		NaN											0	0	0	0.006122	0	16	28									
PDE4A	5141	broad.mit.edu	37	19	10571772	10571772	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10571772C>T	uc002moj.2	+	11	1566	c.1458C>T	c.(1456-1458)ATC>ATT	p.I486I	PDE4A_uc002mok.2_Silent_p.I460I|PDE4A_uc002mol.2_Silent_p.I425I|PDE4A_uc002mom.2_Silent_p.I247I|PDE4A_uc002mon.2_5'UTR|PDE4A_uc002moo.2_Silent_p.I152I	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	486	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	AGTTCCTCATCAACACCAGTG	0.647		NaN											0	0	0	0.001168	0	6	32									
CDKN2D	1032	broad.mit.edu	37	19	10677925	10677925	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10677925C>T	uc002mpa.2	-	2	612	c.310G>A	c.(310-312)GAT>AAT	p.D104N	KRI1_uc002mox.1_5'Flank|KRI1_uc002moy.1_5'Flank|CDKN2D_uc002mpb.2_Missense_Mutation_p.D104N	NM_001800	NP_001791	P55273	CDN2D_HUMAN	cyclin-dependent kinase inhibitor 2D	104					anti-apoptosis|autophagic cell death|cell cycle arrest|DNA synthesis involved in DNA repair|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of caspase activity|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|response to retinoic acid|response to UV|response to vitamin D	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding				0			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CCGGTGCCATCAGGCACGTTG	0.597		NaN							Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				0	0	0	0.004878	0	39	105									
ILF3	3609	broad.mit.edu	37	19	10793282	10793282	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10793282G>A	uc002mpn.2	+	13	1767	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	ILF3_uc002mpm.2_Missense_Mutation_p.E484K|ILF3_uc002mpl.2_Missense_Mutation_p.E484K|ILF3_uc002mpk.2_Missense_Mutation_p.E484K|ILF3_uc010xli.1_Missense_Mutation_p.E82K|ILF3_uc002mpo.2_Missense_Mutation_p.E484K|ILF3_uc002mpp.2_Missense_Mutation_p.E305K	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	484					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			GGACTCGGCTGAGGAGACCGA	0.647		NaN											0	0	0	0.008291	0	10	19									
ILF3	3609	broad.mit.edu	37	19	10793285	10793285	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10793285G>A	uc002mpn.2	+	13	1770	c.1453G>A	c.(1453-1455)GAG>AAG	p.E485K	ILF3_uc002mpm.2_Missense_Mutation_p.E485K|ILF3_uc002mpl.2_Missense_Mutation_p.E485K|ILF3_uc002mpk.2_Missense_Mutation_p.E485K|ILF3_uc010xli.1_Missense_Mutation_p.E83K|ILF3_uc002mpo.2_Missense_Mutation_p.E485K|ILF3_uc002mpp.2_Missense_Mutation_p.E306K	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	485					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CTCGGCTGAGGAGACCGAGGC	0.647		NaN											0	0	0	0.008291	0	10	19									
ILF3	3609	broad.mit.edu	37	19	10793287	10793287	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:10793287G>A	uc002mpn.2	+	13	1772	c.1455G>A	c.(1453-1455)GAG>GAA	p.E485E	ILF3_uc002mpm.2_Silent_p.E485E|ILF3_uc002mpl.2_Silent_p.E485E|ILF3_uc002mpk.2_Silent_p.E485E|ILF3_uc010xli.1_Silent_p.E83E|ILF3_uc002mpo.2_Silent_p.E485E|ILF3_uc002mpp.2_Silent_p.E306E	NM_012218	NP_036350	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3 isoform a	485					M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding|protein binding			ovary(3)	3			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CGGCTGAGGAGACCGAGGCGA	0.647		NaN											0	0	0	0.008291	0	10	19									
C19orf52	90580	broad.mit.edu	37	19	11040318	11040318	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:11040318G>A	uc002mqd.1	+	2	798	c.723G>A	c.(721-723)AAG>AAA	p.K241K	YIPF2_uc002mqb.2_5'Flank|YIPF2_uc002mqc.2_5'Flank	NM_138358	NP_612367	Q9BSF4	CS052_HUMAN	hypothetical protein LOC90580	241											0						AGAAGGAGAAGAAGGACAGGC	0.637		NaN											0	0	0	0.003163	0	15	11									
EPOR	2057	broad.mit.edu	37	19	11493835	11493835	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:11493835G>A	uc002mrj.1	-	2	325	c.189C>T	c.(187-189)TTC>TTT	p.F63F	EPOR_uc002mrh.2_5'Flank|EPOR_uc002mri.2_5'UTR|EPOR_uc002mrk.1_5'UTR|EPOR_uc002mrl.1_RNA|EPOR_uc010xlx.1_RNA|EPOR_uc010xly.1_5'UTR|RGL3_uc002mrn.2_3'UTR|RGL3_uc002mrm.2_3'UTR	NM_000121	NP_000112	P19235	EPOR_HUMAN	erythropoietin receptor precursor	63	Extracellular (Potential).					extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			ovary(1)	1					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CTTCCTCCCAGAAACACACCA	0.682		NaN											0	0	0	0.001984	0	7	21									
CCDC151	115948	broad.mit.edu	37	19	11541826	11541826	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:11541826C>T	uc002mrs.2	-	2	402	c.259G>A	c.(259-261)GCT>ACT	p.A87T	CCDC151_uc002mrr.2_Missense_Mutation_p.A22T|CCDC151_uc010dxz.2_Missense_Mutation_p.A87T	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	87										ovary(1)	1						TCAAAAAAAGCCTTCCGGTCA	0.522		NaN											0	0	0	0.012213	0	31	132									
ACP5	54	broad.mit.edu	37	19	11687879	11687879	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:11687879C>G	uc002msg.3	-	2	400	c.254G>C	c.(253-255)AGG>ACG	p.R85T	ACP5_uc002msh.3_Missense_Mutation_p.R85T|ACP5_uc002msi.3_Missense_Mutation_p.R85T|ACP5_uc002msj.3_Missense_Mutation_p.R85T|ACP5_uc010dye.1_Missense_Mutation_p.R85T	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	85					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						GACCTGGAACCTCTTGTCATT	0.562		NaN											0	0	0	0.010729	0	10	39									
HOOK2	29911	broad.mit.edu	37	19	12885514	12885514	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:12885514G>A	uc002muy.2	-	3	344	c.173C>T	c.(172-174)TCG>TTG	p.S58L	HOOK2_uc002muz.2_Missense_Mutation_p.S58L|HOOK2_uc002mva.2_Missense_Mutation_p.S58L	NM_013312	NP_037444	Q96ED9	HOOK2_HUMAN	hook homolog 2 isoform 1	58	Sufficient for interaction with microtubules.|Required for localization to the centrosome and induction of aggresome formation.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			ovary(1)|breast(1)|skin(1)	3						TGGATCTTCCGAGATGCCCTG	0.587		NaN											0	0	0	0.00499	0	15	28									
MAST1	22983	broad.mit.edu	37	19	12958498	12958498	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:12958498G>A	uc002mvm.2	+	6	689	c.561G>A	c.(559-561)CCG>CCA	p.P187P	MAST1_uc002mvk.2_Silent_p.P183P|MAST1_uc002mvl.2_3'UTR	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	187					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						AGAGGTTCCCGAAGGTGAGGT	0.672		NaN									OREG0025277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	11	18									
NACC1	112939	broad.mit.edu	37	19	13246852	13246852	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:13246852C>T	uc002mwm.2	+	2	999	c.831C>T	c.(829-831)TCC>TCT	p.S277S		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	277					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						GCCCTGGCTCCTACCACAATG	0.627		NaN											0	0	0	0.00499	0	14	12									
IER2	9592	broad.mit.edu	37	19	13264058	13264058	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:13264058C>T	uc002mwr.2	+	2	386	c.58C>T	c.(58-60)CAC>TAC	p.H20Y		NM_004907	NP_004898	Q9BTL4	IER2_HUMAN	immediate early response 2	20										kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			GAAGATGTATCACTCCCGCAT	0.667		NaN									OREG0025291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	5									
CACNA1A	773	broad.mit.edu	37	19	13325339	13325339	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:13325339C>G	uc010dze.2	-	39	6054	c.5818G>C	c.(5818-5820)GAC>CAC	p.D1940H	CACNA1A_uc010xnd.1_Missense_Mutation_p.D645H|CACNA1A_uc002mwx.3_Missense_Mutation_p.D645H|CACNA1A_uc010dzc.2_Missense_Mutation_p.D1465H|CACNA1A_uc002mwy.3_Missense_Mutation_p.D1939H|CACNA1A_uc002mwv.3_Missense_Mutation_p.D456H	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1940	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACCAGCAGGTCTAGCGTCTTC	0.597		NaN											0	0	0	0.004482	0	8	12									
CACNA1A	773	broad.mit.edu	37	19	13470507	13470507	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:13470507C>T	uc010dze.2	-	6	1127	c.891G>A	c.(889-891)GGG>GGA	p.G297G	CACNA1A_uc002mwy.3_Silent_p.G297G	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	297	I.|Extracellular (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACTGAGTGATCCCGTTGTTGG	0.547		NaN											0	0	0	0.004672	0	3	8									
CD97	976	broad.mit.edu	37	19	14507162	14507162	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:14507162G>A	uc002myl.2	+	5	478	c.355G>A	c.(355-357)GAA>AAA	p.E119K	CD97_uc002mym.2_Missense_Mutation_p.E119K|CD97_uc002myn.2_Intron	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	119	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						AGATGTGGACGAATGTCAGCA	0.562		NaN											0	0	0	0.00278	0	25	81									
OR7A17	26333	broad.mit.edu	37	19	14991344	14991344	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:14991344G>A	uc010xob.1	-	1	824	c.824C>T	c.(823-825)TCA>TTA	p.S275L		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	275	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					GTACATCACTGAGGCTGTTGC	0.473		NaN											0	0	0	0.005443	0	27	74									
CYP4F22	126410	broad.mit.edu	37	19	15648197	15648197	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:15648197C>T	uc002nbh.3	+	5	560	c.393C>T	c.(391-393)CTC>CTT	p.L131L		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	131						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						AGGATGACCTCTTCTATGGCT	0.453		NaN											0	0	0	0.00333	0	20	72									
EPS15L1	58513	broad.mit.edu	37	19	16535906	16535906	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:16535906G>A	uc002ndz.1	-	9	786	c.780C>T	c.(778-780)CTC>CTT	p.L260L	EPS15L1_uc002ndx.2_Silent_p.L260L|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.L150L|EPS15L1_uc010xpf.1_Silent_p.L163L|EPS15L1_uc002nea.1_Silent_p.L260L|EPS15L1_uc010eah.1_Silent_p.L260L|EPS15L1_uc002neb.1_Silent_p.L106L|EPS15L1_uc002nec.1_Silent_p.L260L	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	260					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						GTGTTTGCTTGAGGCTGTGCT	0.622		NaN											0	0	0	0.00499	0	16	60									
OCEL1	79629	broad.mit.edu	37	19	17339098	17339098	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17339098G>T	uc002nfp.2	+	5	654	c.652G>T	c.(652-654)GAG>TAG	p.E218*		NM_024578	NP_078854	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	218										central_nervous_system(1)	1						GGTTTGGAGGGAGTTTGAGAT	0.493		NaN											1	0	7.11191e-15	0.013726	7.46269e-15	35	90									
USHBP1	83878	broad.mit.edu	37	19	17375060	17375060	+	Missense_Mutation	SNP	G	G	A	rs149022063	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17375060G>A	uc002nfs.1	-	2	162	c.49C>T	c.(49-51)CCA>TCA	p.P17S	USHBP1_uc002nft.1_RNA|USHBP1_uc010xpk.1_Silent_p.L2L|USHBP1_uc010eam.1_5'UTR	NM_031941	NP_114147	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	17							PDZ domain binding			ovary(1)	1						CTTACGGGTGGAGCATGCCTC	0.652		NaN											0	0	0	0.000602	0	4	21									
PLVAP	83483	broad.mit.edu	37	19	17476312	17476312	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17476312G>A	uc002ngk.1	-	3	1012	c.962C>T	c.(961-963)GCG>GTG	p.A321V		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	321	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CTTCTGTTTCGCCTCCTGACT	0.667		NaN											0	0	0	0.004482	0	9	33									
SLC27A1	376497	broad.mit.edu	37	19	17608118	17608118	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17608118G>A	uc002ngu.1	+	7	1101	c.1051G>A	c.(1051-1053)GAG>AAG	p.E351K	SLC27A1_uc002ngt.1_Missense_Mutation_p.E83K|SLC27A1_uc010xpp.1_Missense_Mutation_p.E172K|SLC27A1_uc002ngv.1_5'UTR	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	351	Sufficient for oligomerization (By similarity).|Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						GCCGGTGCGCGAGGCGGAGAG	0.687		NaN											0	0	0	0.001984	0	3	10									
JAK3	3718	broad.mit.edu	37	19	17942579	17942579	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:17942579C>T	uc002nhn.3	-	20	2809	c.2709G>A	c.(2707-2709)GAG>GAA	p.E903E	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Silent_p.E903E	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	903	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TGGGCAGGTACTCCATGACCA	0.662		2	Mis		acute megakaryocytic leukemia|								0	0	0	0.004482	0	7	16									
NCAN	1463	broad.mit.edu	37	19	19359535	19359535	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:19359535G>T	uc002nlz.2	+	14	3763	c.3664G>T	c.(3664-3666)GAG>TAG	p.E1222*	NCAN_uc002nma.2_5'UTR	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1222	Sushi.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			TCCGGCAGTGGAGAATGCCTC	0.498		NaN											1	0	2.0095e-06	0.001984	2.05981e-06	7	24									
SF4	57794	broad.mit.edu	37	19	19420949	19420949	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:19420949G>A	uc002nmh.2	-	3	269	c.267C>T	c.(265-267)TTC>TTT	p.F89F	SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_Intron|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	89					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						ACTGCTGCAAGAAGCTACCAT	0.517		NaN											0	0	0	0.004007	0	15	65									
PBX4	80714	broad.mit.edu	37	19	19675894	19675894	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:19675894G>A	uc002nmy.2	-	6	774	c.773C>T	c.(772-774)TCT>TTT	p.S258F	PBX4_uc010xqz.1_RNA|PBX4_uc010xra.1_Missense_Mutation_p.S93F	NM_025245	NP_079521	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	258	Homeobox; TALE-type.						sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						AAACCAGTTAGAGACCTGCGG	0.532		NaN											0	0	0	0.01441	0	123	129									
ZNF493	284443	broad.mit.edu	37	19	21607496	21607496	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:21607496C>G	uc002npx.2	+	2	1931	c.1651C>G	c.(1651-1653)CAT>GAT	p.H551D	ZNF493_uc002npw.2_Missense_Mutation_p.H679D|ZNF493_uc002npy.2_Missense_Mutation_p.H551D	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	551	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAAGATAATTCATACTGAAGA	0.348		NaN											0	0	0	0.001984	0	7	36									
ZNF429	353088	broad.mit.edu	37	19	21719352	21719352	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:21719352G>C	uc002nqd.1	+	4	634	c.497G>C	c.(496-498)AGA>ACA	p.R166T	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	166	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TACAAGACAAGACATACTGGA	0.313		NaN											0	0	0	0.001984	0	7	54									
ZNF676	163223	broad.mit.edu	37	19	22364107	22364107	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:22364107C>T	uc002nqs.1	-	3	730	c.412G>A	c.(412-414)GAG>AAG	p.E138K		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAACCTTTCTCTCCAGTATGC	0.318		NaN											0	0	0	0.014323	0	21	105									
ZNF254	9534	broad.mit.edu	37	19	24309428	24309428	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:24309428C>T	uc002nru.2	+	4	760	c.626C>T	c.(625-627)TCC>TTC	p.S209F	ZNF254_uc010xrk.1_Missense_Mutation_p.S124F	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	209					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AGAGAGAAGTCCTACAAATGT	0.303		NaN											0	0	0	0.012319	0	21	66									
ZNF507	22847	broad.mit.edu	37	19	32845546	32845546	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:32845546G>A	uc002nte.2	+	3	2082	c.1810G>A	c.(1810-1812)GAC>AAC	p.D604N	ZNF507_uc002ntc.2_Missense_Mutation_p.D604N|ZNF507_uc010xrn.1_Missense_Mutation_p.D604N|ZNF507_uc002ntd.2_Missense_Mutation_p.D604N	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	604					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					AAACGCTTCAGACGATGACAT	0.468		NaN											0	0	0	0.001984	0	6	41									
C19orf40	91442	broad.mit.edu	37	19	33467474	33467474	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:33467474C>T	uc002nud.3	+	5	652	c.534C>T	c.(532-534)CTC>CTT	p.L178L		NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	178	RuvA domain 2-like.				DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					CCCTTCTCCTCCAGAAGTTTC	0.542		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00632	0	29	114									
GPATCH1	55094	broad.mit.edu	37	19	33579137	33579137	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:33579137C>T	uc002nug.1	+	2	485	c.171C>T	c.(169-171)TTC>TTT	p.F57F		NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	57						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					GTGGAGGTTTCTCTGCTGGAT	0.383		NaN											0	0	0	0.007291	0	26	59									
ZNF302	55900	broad.mit.edu	37	19	35175770	35175770	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:35175770G>A	uc002nvr.1	+	6	1223	c.960G>A	c.(958-960)CAG>CAA	p.Q320Q	ZNF302_uc002nvp.1_Silent_p.Q276Q|ZNF302_uc002nvq.1_Silent_p.Q276Q|ZNF302_uc002nvs.1_Silent_p.Q276Q	NM_018443	NP_060913	Q9NR11	ZN302_HUMAN	zinc finger protein 302	355	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CTAACCATCAGAGCACTCACA	0.438		NaN											0	0	0	0.008871	0	18	68									
ZNF792	126375	broad.mit.edu	37	19	35451187	35451187	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:35451187C>T	uc002nxh.1	-	3	622	c.235G>A	c.(235-237)GAT>AAT	p.D79N		NM_175872	NP_787068	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GATGTCATATCCACACTGTCA	0.537		NaN											0	0	0	0.008291	0	7	35									
GRAMD1A	57655	broad.mit.edu	37	19	35512680	35512680	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:35512680G>A	uc010xse.1	+	15	1802	c.1665G>A	c.(1663-1665)CGG>CGA	p.R555R	GRAMD1A_uc002nxk.2_Silent_p.R548R|GRAMD1A_uc002nxl.2_Silent_p.R321R|GRAMD1A_uc010xsf.1_Silent_p.R560R|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Silent_p.R170R	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	555						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			TGCGGCGGCGGAAGCGGCCCC	0.682		NaN											0	0	0	0.004482	0	7	17									
ARHGAP33	115703	broad.mit.edu	37	19	36278895	36278895	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:36278895C>T	uc002obs.1	+	21	3030	c.2945C>T	c.(2944-2946)TCC>TTC	p.S982F	ARHGAP33_uc002obt.1_Missense_Mutation_p.S979F|ARHGAP33_uc010eel.2_Intron|ARHGAP33_uc002obv.1_Missense_Mutation_p.S731F	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	1143					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						CCAGCCCCCTCCTGCTTTCCC	0.667		NaN											0	0	0	0.004672	0	3	8									
WDR62	284403	broad.mit.edu	37	19	36590419	36590419	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:36590419A>G	uc002odc.2	+	22	2730	c.2639A>G	c.(2638-2640)CAG>CGG	p.Q880R	WDR62_uc002odd.2_Missense_Mutation_p.Q880R	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	880					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTGGATGCCCAGGACCTGGAT	0.632		NaN											0	0	0	0.010818	0	33	47									
ZNF565	147929	broad.mit.edu	37	19	36673778	36673778	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:36673778C>T	uc002odn.2	-	5	1198	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K	ZNF565_uc010ees.2_Missense_Mutation_p.E299K|ZNF565_uc002odo.2_Missense_Mutation_p.E364K	NM_152477	NP_689690	Q8N9K5	ZN565_HUMAN	zinc finger protein 565	364	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			TCCTTACACTCATAGGGTTTC	0.488		NaN											0	0	0	0.012213	0	30	71									
SIPA1L3	23094	broad.mit.edu	37	19	38597188	38597188	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:38597188G>A	uc002ohk.2	+	7	2550	c.2041G>A	c.(2041-2043)GGA>AGA	p.G681R		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	681	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CGACTCCACGGGAACCCACTC	0.413		NaN											0	0	0	0.010729	0	8	103									
IL28B	282617	broad.mit.edu	37	19	39734518	39734518	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39734518C>G	uc010xut.1	-	4	442	c.438G>C	c.(436-438)AGG>AGC	p.R146S	IL28B_uc010xuu.1_Missense_Mutation_p.R146S	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	146					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGCCCCGGGTCCTGGGCCCTG	0.687		NaN											0	0	0	0.013537	0	6	8									
IL28B	282617	broad.mit.edu	37	19	39734756	39734756	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39734756C>T	uc010xut.1	-	3	304	c.300G>A	c.(298-300)CTG>CTA	p.L100L	IL28B_uc010xuu.1_Silent_p.L100L	NM_172139	NP_742151	Q8IZI9	IL28B_HUMAN	interleukin 28B	100					response to virus	extracellular space	cytokine activity				0	all_cancers(60;2.81e-07)|all_lung(34;7.81e-08)|Lung NSC(34;9.29e-08)|all_epithelial(25;3.9e-07)|Ovarian(47;0.0315)		Epithelial(26;1.55e-27)|all cancers(26;1.41e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCTTCAGCGTCAGGGCCAGCT	0.473		NaN											0	0	0	0.007413	0	18	21									
SAMD4B	55095	broad.mit.edu	37	19	39868130	39868130	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39868130G>A	uc002olb.2	+	10	2145	c.1110G>A	c.(1108-1110)GTG>GTA	p.V370V	SAMD4B_uc002ola.2_Silent_p.V370V	NM_018028	NP_060498	Q5PRF9	SMAG2_HUMAN	sterile alpha motif domain containing 4B	370	SAM.						protein binding				0	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			TCCAGGATGTGCTGGAAGGCG	0.582		NaN											0	0	0	0.006122	0	17	58									
RPS16	6217	broad.mit.edu	37	19	39926340	39926340	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39926340C>T	uc002olk.2	-	2	140	c.57G>A	c.(55-57)GCG>GCA	p.A19A	RPS16_uc002oll.2_Silent_p.A19A|RPS16_uc002olm.2_Silent_p.A19A	NM_001020	NP_001011	P62249	RS16_HUMAN	ribosomal protein S16	19					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			skin(1)	1	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;4.14e-26)|all cancers(26;2.68e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCACAGCTGTCGCTGTCTTCT	0.602		NaN											0	0	0	0.000602	0	4	31									
SUPT5H	6829	broad.mit.edu	37	19	39965239	39965239	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:39965239G>T	uc002olo.3	+	28	3084	c.2905G>T	c.(2905-2907)GGC>TGC	p.G969C	SUPT5H_uc002olp.3_Missense_Mutation_p.G969C|SUPT5H_uc002olq.3_Missense_Mutation_p.G965C|SUPT5H_uc002oln.3_Missense_Mutation_p.G969C|SUPT5H_uc002olr.3_Missense_Mutation_p.G969C|SUPT5H_uc002ols.1_Missense_Mutation_p.G592C	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	969					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			ACACACGCCAGGCTCAGGCAT	0.617		NaN									OREG0025462	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.51602e-12	0.008871	3.67699e-12	19	31									
LGALS13	29124	broad.mit.edu	37	19	40097960	40097960	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40097960C>T	uc002omb.2	+	4	441	c.401C>T	c.(400-402)TCA>TTA	p.S134L		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	134	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			TCCCTGACCTCAGTGTGTGTC	0.463		NaN											0	0	0	0.009718	0	42	53									
FCGBP	8857	broad.mit.edu	37	19	40433739	40433739	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40433739G>A	uc002omp.3	-	2	538	c.530C>T	c.(529-531)TCA>TTA	p.S177L		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	177	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAATGTCACTGACCCCTTCAG	0.577		NaN											0	0	0	0.01441	0	52	60									
ZNF780B	163131	broad.mit.edu	37	19	40542198	40542198	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40542198C>T	uc002omu.2	-	5	633	c.568G>A	c.(568-570)GAG>AAG	p.E190K	ZNF780B_uc002omv.2_Missense_Mutation_p.E42K	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TAGGGTTTCTCTCCAGTATGA	0.338		NaN											0	0	0	0.001855	0	13	102									
ZNF780B	163131	broad.mit.edu	37	19	40542207	40542207	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40542207G>A	uc002omu.2	-	5	624	c.559C>T	c.(559-561)CAT>TAT	p.H187Y	ZNF780B_uc002omv.2_Missense_Mutation_p.H39Y	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	187	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCTCCAGTATGAATACTCTGA	0.348		NaN											0	0	0	0.00245	0	14	102									
MAP3K10	4294	broad.mit.edu	37	19	40715101	40715101	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40715101C>T	uc002ona.2	+	6	1815	c.1527C>T	c.(1525-1527)ATC>ATT	p.I509I	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	509					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						GCCCCAGCATCATCCCCCGGC	0.468		NaN											0	0	0	0.005524	0	35	52									
SERTAD3	29946	broad.mit.edu	37	19	40947819	40947819	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:40947819G>A	uc002onu.3	-	2	447	c.169C>T	c.(169-171)CTC>TTC	p.L57F	SERTAD3_uc002onv.3_Missense_Mutation_p.L57F	NM_013368	NP_037500	Q9UJW9	SRTD3_HUMAN	RPA-binding trans-activator	57	SERTA.				negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding				0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TTATGGATGAGGACATGCCTG	0.662		NaN											0	0	0	0.001168	0	5	11									
SPTBN4	57731	broad.mit.edu	37	19	41008759	41008759	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41008759G>A	uc002ony.2	+	11	1367	c.1281G>A	c.(1279-1281)CTG>CTA	p.L427L	SPTBN4_uc002onx.2_Silent_p.L427L|SPTBN4_uc002onz.2_Silent_p.L427L	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	427					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGAGAAGCTGGAACTACTGG	0.597		NaN											0	0	0	0.01441	0	50	70									
SHKBP1	92799	broad.mit.edu	37	19	41088265	41088265	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41088265C>T	uc002oob.2	+	10	902	c.853C>T	c.(853-855)CAT>TAT	p.H285Y	SHKBP1_uc002ooc.2_Intron|SHKBP1_uc002ood.2_Missense_Mutation_p.H285Y|SHKBP1_uc010xvl.1_Missense_Mutation_p.H208Y|SHKBP1_uc002ooe.2_Missense_Mutation_p.H122Y|SHKBP1_uc002oof.2_Missense_Mutation_p.H122Y|SHKBP1_uc010xvm.1_Missense_Mutation_p.H122Y|SHKBP1_uc010xvn.1_Missense_Mutation_p.H163Y	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	285	WD 2.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGGGTCTTTCATCTGGGGGT	0.597		NaN											0	0	0	0.014323	0	23	92									
LTBP4	8425	broad.mit.edu	37	19	41117097	41117097	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41117097G>A	uc002ooh.1	+	16	2051	c.2051G>A	c.(2050-2052)CGA>CAA	p.R684Q	LTBP4_uc002oog.1_Missense_Mutation_p.R647Q|LTBP4_uc002ooi.1_Missense_Mutation_p.R617Q|LTBP4_uc002ooj.1_Intron|LTBP4_uc010xvo.1_Intron|LTBP4_uc010ehb.1_5'Flank|LTBP4_uc002ook.1_5'Flank|LTBP4_uc002ool.1_5'Flank|LTBP4_uc002oom.1_5'Flank|LTBP4_uc010xvp.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	684	Cys-rich.|EGF-like 6; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGTGTGGCCGAGGGGCCTGC	0.647		NaN											0	0	0	0.001168	0	6	35									
LTBP4	8425	broad.mit.edu	37	19	41118028	41118028	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41118028G>A	uc002ooh.1	+	18	2430	c.2430G>A	c.(2428-2430)GTG>GTA	p.V810V	LTBP4_uc002oog.1_Silent_p.V773V|LTBP4_uc002ooi.1_Silent_p.V743V|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc010xvo.1_Silent_p.V98V|LTBP4_uc010ehb.1_Silent_p.V30V|LTBP4_uc002ook.1_Silent_p.V30V|LTBP4_uc002ool.1_5'Flank|LTBP4_uc002oom.1_5'Flank|LTBP4_uc010xvp.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	810	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGAGTGTGTGAACTCGCCCG	0.637		NaN											0	0	0	0.001168	0	4	15									
CYP2A6	1548	broad.mit.edu	37	19	41349839	41349839	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:41349839G>A	uc002opl.3	-	9	1368	c.1347C>T	c.(1345-1347)CTC>CTT	p.L449L		NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	449					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	AGAAGAGAAAGAGCTCCATTC	0.587		NaN											0	0	0	0.003163	0	9	55									
GRIK5	2901	broad.mit.edu	37	19	42557979	42557979	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42557979C>T	uc002osj.1	-	9	1194	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	GRIK5_uc010eib.1_Missense_Mutation_p.E306K	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	387	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	CTGCTCACCTCACGGTGGCCC	0.647		NaN											0	0	0	0.001168	0	4	28									
ZNF574	64763	broad.mit.edu	37	19	42584118	42584118	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42584118G>C	uc002osm.3	+	2	1529	c.1360G>C	c.(1360-1362)GAG>CAG	p.E454Q	ZNF574_uc002osk.3_Missense_Mutation_p.E544Q	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				CCCTGTGTCTGAGGAGACCTC	0.637		NaN											0	0	0	0.004289	0	38	40									
TMEM145	284339	broad.mit.edu	37	19	42827892	42827892	+	Missense_Mutation	SNP	C	C	G	rs149140216		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42827892C>G	uc002otk.1	+	14	1404	c.1352C>G	c.(1351-1353)TCG>TGG	p.S451W	MEGF8_uc002otl.3_5'Flank	NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	451						integral to membrane					0		Prostate(69;0.00682)				ATCAGCGACTCGGTGCCCAAC	0.682		NaN											0	0	0	0.010729	0	11	46									
MEGF8	1954	broad.mit.edu	37	19	42854308	42854308	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42854308C>T	uc002otl.3	+	14	2942	c.2307C>T	c.(2305-2307)TCC>TCT	p.S769S	MEGF8_uc002otm.3_Silent_p.S377S	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	836	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				AGGAGATCTCCTTCTTCTTCC	0.607		NaN											0	0	0	0.003163	0	15	86									
LIPE	3991	broad.mit.edu	37	19	42930623	42930623	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:42930623C>G	uc002otr.2	-	1	956	c.679G>C	c.(679-681)GAG>CAG	p.E227Q	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	227					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				GTGACCCACTCAGAAAGTGCC	0.493		NaN											0	0	0	0.01441	0	46	131									
PSG7	5676	broad.mit.edu	37	19	43428961	43428961	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:43428961C>T	uc002ovl.3	-	7	1361	c.1259G>A	c.(1258-1260)TGA>TAA	p.*420*	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Silent_p.*298*	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	420					female pregnancy	extracellular region					0		Prostate(69;0.00682)				tagtagaattcagggtaatgt	0		NaN											0	0	0	0.008871	0	20	83									
CD177	57126	broad.mit.edu	37	19	43866321	43866321	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:43866321G>T	uc002owi.2	+	10	1205	c.1163G>T	c.(1162-1164)GGG>GTG	p.G388V	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	388					blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				AGACAAATCGGGATCTTCTCT	0.592		NaN											1	0	1.76689e-08	0.006214	1.82753e-08	8	79									
LYPD5	284348	broad.mit.edu	37	19	44302740	44302740	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44302740C>T	uc002oxm.3	-	4	465	c.384G>A	c.(382-384)CCG>CCA	p.P128P	LYPD5_uc002oxn.3_Silent_p.P85P	NM_001031749	NP_001026919	Q6UWN5	LYPD5_HUMAN	LY6/PLAUR domain containing 5 isoform A	128						anchored to membrane|plasma membrane					0		Prostate(69;0.0352)				CGCTGAGCGTCGGCGGGTCGG	0.677		NaN											0	0	0	0.008291	0	11	50									
ZNF283	284349	broad.mit.edu	37	19	44351438	44351438	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44351438C>T	uc002oxr.3	+	7	953	c.685C>T	c.(685-687)CAT>TAT	p.H229Y	ZNF283_uc002oxp.3_Missense_Mutation_p.H90Y	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TGAGAGAACTCATACAGCTGA	0.368		NaN											0	0	0	0.005524	0	37	64									
ZNF230	7773	broad.mit.edu	37	19	44514653	44514653	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44514653C>G	uc002oyb.1	+	5	713	c.462C>G	c.(460-462)ATC>ATG	p.I154M		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	154	KRNB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				ATGTTGCCATCTTTGATCCTC	0.448		NaN											0	0	0	0.010818	0	33	146									
ZNF284	342909	broad.mit.edu	37	19	44585289	44585289	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44585289C>T	uc002oyg.1	+	3	353	c.137C>T	c.(136-138)TCA>TTA	p.S46L	ZNF284_uc010ejd.2_RNA	NM_001037813	NP_001032902	Q2VY69	ZN284_HUMAN	zinc finger protein 284	46	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0435)				AACCTGCTATCAGTGGGTGAG	0.468		NaN											0	0	0	0.013114	0	48	83									
ZNF226	7769	broad.mit.edu	37	19	44676255	44676255	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:44676255C>T	uc002oyp.2	+	4	174	c.30C>T	c.(28-30)TTC>TTT	p.F10F	ZNF226_uc002oyn.2_Silent_p.F10F|ZNF226_uc002oyo.2_Silent_p.F10F|ZNF226_uc002oyq.2_5'UTR|ZNF226_uc002oyr.2_5'UTR|ZNF226_uc010ejg.2_Silent_p.F10F|ZNF226_uc002oys.2_Silent_p.F10F|ZNF226_uc002oyt.2_Silent_p.F10F	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				CAGTGACCTTCAAGGACGTGG	0.507		NaN											0	0	0	0.01441	0	52	89									
PVRL2	5819	broad.mit.edu	37	19	45391385	45391385	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:45391385G>C	uc002ozw.1	+	9	1756	c.1366G>C	c.(1366-1368)GAG>CAG	p.E456Q		NM_001042724	NP_001036189	Q92692	PVRL2_HUMAN	poliovirus receptor related 2 isoform delta	456	Cytoplasmic (Potential).				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		TCGATACCATGAGCTGCCCAC	0.572		NaN											0	0	0	0.007413	0	18	77									
ERCC2	2068	broad.mit.edu	37	19	45873455	45873455	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:45873455T>C	uc002pbj.2	-	2	88	c.41A>G	c.(40-42)TAC>TGC	p.Y14C	ERCC2_uc010ejz.2_Missense_Mutation_p.Y14C|ERCC2_uc002pbk.2_5'UTR|ERCC2_uc002pbl.3_5'UTR|ERCC2_uc010xxj.1_RNA	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	14	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		GATGTAGTCGTACGGGAAGTA	0.682		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.001855	0	12	27									
SIX5	147912	broad.mit.edu	37	19	46271356	46271356	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:46271356G>A	uc002pdb.2	-	1	1142	c.747C>T	c.(745-747)TTC>TTT	p.F249F	SIX5_uc002pdc.2_Silent_p.F249F	NM_175875	NP_787071	Q8N196	SIX5_HUMAN	SIX homeobox 5	249	Homeobox.					cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00783)|GBM - Glioblastoma multiforme(486;0.0802)|Epithelial(262;0.235)		GCCGGTTCTTGAACCAGTTGC	0.716		NaN											0	0	0	0.000602	0	5	15									
PNMAL2	57469	broad.mit.edu	37	19	46997390	46997390	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:46997390C>T	uc002pes.2	-	1	1780	c.1333G>A	c.(1333-1335)GAA>AAA	p.E445K	uc002peu.1_5'Flank	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	445										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		AGACCCCCTTCGTCCTCACGG	0.642		NaN											0	0	0	0.009535	0	27	50									
HSD17B14	51171	broad.mit.edu	37	19	49334955	49334955	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:49334955C>T	uc002pkv.1	-	5	605	c.339G>A	c.(337-339)CTG>CTA	p.L113L	HSD17B14_uc010emk.1_Silent_p.L113L	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	113					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		CCAGTAGGTTCAGCTCCAGCA	0.607		NaN											0	0	0	0.00278	0	20	98									
FTL	2512	broad.mit.edu	37	19	49469600	49469600	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:49469600G>T	uc002plo.2	+	3	511	c.312G>T	c.(310-312)GAG>GAT	p.E104D	FTL_uc002pln.1_3'UTR	NM_000146	NP_000137	P02792	FRIL_HUMAN	ferritin, light polypeptide	104	Ferritin-like diiron.				cell death|cellular iron ion homeostasis|cellular membrane organization|iron ion transport|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|identical protein binding|oxidoreductase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000152)|all cancers(93;0.000435)|GBM - Glioblastoma multiforme(486;0.0171)|Epithelial(262;0.0267)	Iron Dextran(DB00893)	TGGCCCTGGAGAAAAAGCTGA	0.537		NaN											1	0	9.86323e-18	0.003954	1.04101e-17	26	31									
TEAD2	8463	broad.mit.edu	37	19	49846565	49846565	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:49846565C>T	uc002pnj.2	-	10	1091	c.1000G>A	c.(1000-1002)GAG>AAG	p.E334K	TEAD2_uc002png.2_Missense_Mutation_p.E337K|TEAD2_uc002pnh.2_Missense_Mutation_p.E338K|TEAD2_uc002pni.2_Missense_Mutation_p.E337K|TEAD2_uc010yao.1_Missense_Mutation_p.E206K|TEAD2_uc010emw.2_Missense_Mutation_p.E337K	NM_003598	NP_003589	Q15562	TEAD2_HUMAN	TEA domain family member 2	334	Transcriptional activation (Potential).				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3		all_lung(116;7.65e-05)|Lung NSC(112;0.000132)|all_neural(266;0.0506)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00093)|GBM - Glioblastoma multiforme(486;0.0467)		TCCAGGCTCTCATACTGGCTG	0.617		NaN											0	0	0	0.00278	0	19	51									
TSKS	60385	broad.mit.edu	37	19	50243401	50243401	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:50243401C>T	uc002ppm.2	-	10	1548	c.1537G>A	c.(1537-1539)GAG>AAG	p.E513K		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	513							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CTCAGGGCCTCTGCCCTGACG	0.647		NaN											0	0	0	0.008871	0	17	72									
TSKS	60385	broad.mit.edu	37	19	50245148	50245148	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:50245148C>G	uc002ppm.2	-	9	1502	c.1491G>C	c.(1489-1491)AAG>AAC	p.K497N		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	497							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GTACCAGAATCTTCTTGTGTA	0.582		NaN											0	0	0	0.013114	0	43	70									
IL4I1	259307	broad.mit.edu	37	19	50393764	50393764	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:50393764C>T	uc002pqt.1	-	8	945	c.867G>A	c.(865-867)GCG>GCA	p.A289A	IL4I1_uc002pqv.1_Silent_p.A298A|IL4I1_uc010eno.1_Silent_p.A297A|IL4I1_uc002pqw.1_Silent_p.A297A|IL4I1_uc002pqu.1_Silent_p.A311A	NM_152899	NP_690863	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1 isoform 1 precursor	289						lysosome	L-amino-acid oxidase activity			lung(1)|ovary(1)|prostate(1)	3		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		CCTGGGTCATCGCCACCACGG	0.682		NaN									OREG0025629	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	14									
NUP62	23636	broad.mit.edu	37	19	50412045	50412045	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:50412045C>A	uc002pqx.2	-	2	1124	c.1020G>T	c.(1018-1020)TGG>TGT	p.W340C	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.W340C|NUP62_uc002pqz.2_Missense_Mutation_p.W340C|NUP62_uc002pra.2_Missense_Mutation_p.W340C|NUP62_uc002prb.2_Missense_Mutation_p.W340C|NUP62_uc002prc.2_Intron	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	340	Potential.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		GCTCCAGGCTCCATTTGTTGA	0.647		NaN											1	0	2.73361e-28	0.01441	2.89787e-28	66	99									
JOSD2	126119	broad.mit.edu	37	19	51009492	51009492	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:51009492C>T	uc002psn.1	-	5	536	c.505G>A	c.(505-507)GAG>AAG	p.E169K	JOSD2_uc002pso.1_Missense_Mutation_p.E169K|JOSD2_uc002psp.1_Missense_Mutation_p.E169K|JOSD2_uc002psq.1_Missense_Mutation_p.E127K	NM_138334	NP_612207	Q8TAC2	JOS2_HUMAN	Josephin domain containing 2	169	Josephin.				protein deubiquitination		ubiquitin-specific protease activity				0		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0364)		AGCAGCACCTCGCACAGGCCC	0.682		NaN											0	0	0	0.001168	0	6	42									
SHANK1	50944	broad.mit.edu	37	19	51219555	51219555	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:51219555C>G	uc002psx.1	-	2	455	c.436G>C	c.(436-438)GAG>CAG	p.E146Q		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	146					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		ACCCCCTTCTCAAAGGACTGG	0.582		NaN											0	0	0	0.01441	0	47	75									
KLK11	11012	broad.mit.edu	37	19	51527533	51527533	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:51527533G>T	uc002pvd.1	-	4	439	c.327C>A	c.(325-327)CTC>CTA	p.L109L	KLK11_uc002pvb.1_Silent_p.L102L|KLK11_uc002pve.1_5'UTR|KLK11_uc002pvf.1_Silent_p.L77L|KLK11_uc002pvc.3_Silent_p.L77L|KLK11_uc010eom.2_Missense_Mutation_p.P79T	NM_144947	NP_659196	Q9UBX7	KLK11_HUMAN	kallikrein 11 isoform 2 precursor	109	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|GBM - Glioblastoma multiforme(134;0.00878)		CCTCCTTCTGGAGGTTGTGCT	0.602		NaN											1	0	1.38814e-16	0.01441	1.46226e-16	55	56									
SIGLEC10	89790	broad.mit.edu	37	19	51920200	51920200	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:51920200C>T	uc002pwo.2	-	3	1042	c.426G>A	c.(424-426)CTG>CTA	p.L142L	SIGLEC10_uc002pwp.2_Intron|SIGLEC10_uc002pwq.2_Intron|SIGLEC10_uc002pwr.2_Silent_p.L142L|SIGLEC10_uc010ycy.1_Silent_p.L142L|SIGLEC10_uc010ycz.1_Intron|SIGLEC10_uc010eow.2_5'UTR|SIGLEC10_uc002pws.1_Intron	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	142	Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GCTTCTGAGTCAGGGCTGGGA	0.622		NaN											0	0	0	0.01441	0	90	72									
ZNF615	284370	broad.mit.edu	37	19	52498046	52498046	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52498046G>A	uc002pye.1	-	6	575	c.283C>T	c.(283-285)CAA>TAA	p.Q95*	ZNF615_uc002pyf.1_Nonsense_Mutation_p.Q106*|ZNF615_uc002pyg.1_5'UTR|ZNF615_uc002pyh.1_Nonsense_Mutation_p.Q106*|ZNF615_uc010epi.1_Nonsense_Mutation_p.Q102*|ZNF615_uc010ydg.1_Nonsense_Mutation_p.Q100*	NM_198480	NP_940882	Q8N8J6	ZN615_HUMAN	zinc finger protein 615	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGAATACTTTGATTTTGCAAG	0.348		NaN											0	0	0	0.012319	0	21	148									
ZNF841	284371	broad.mit.edu	37	19	52568426	52568426	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52568426G>A	uc002pyl.1	-	5	2913	c.2361C>T	c.(2359-2361)AAC>AAT	p.N787N	ZNF841_uc010ydh.1_Silent_p.N903N|ZNF841_uc010epk.1_Silent_p.N479N	NM_001136499	NP_001129971	Q6ZN19	ZN841_HUMAN	zinc finger protein 841	787					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGTTGTAAGGTTCTCTCCAG	0.338		NaN											0	0	0	0.006214	0	9	62									
ZNF616	90317	broad.mit.edu	37	19	52618287	52618287	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52618287G>A	uc002pym.2	-	4	2413	c.2130C>T	c.(2128-2130)ATC>ATT	p.I710I	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	710	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		CTCCAGTGTGGATTCTCTGGT	0.398		NaN											0	0	0	0.01441	0	50	362									
ZNF836	162962	broad.mit.edu	37	19	52659824	52659824	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52659824G>A	uc010ydi.1	-	5	1486	c.1112C>T	c.(1111-1113)TCT>TTT	p.S371F	ZNF836_uc010ydj.1_Missense_Mutation_p.S371F	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	371	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TACAAGATTAGAATTCTGCCT	0.403		NaN											0	0	0	0.013726	0	34	79									
ZNF836	162962	broad.mit.edu	37	19	52663830	52663830	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52663830G>A	uc010ydi.1	-	4	404	c.30C>T	c.(28-30)TTC>TTT	p.F10F	ZNF836_uc010ydj.1_Silent_p.F10F	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTACATCCCTGAATGTCAAAG	0.433		NaN											0	0	0	0.008871	0	20	174									
ZNF534	147658	broad.mit.edu	37	19	52937222	52937222	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:52937222C>A	uc002pzk.2	+	2	91	c.30C>A	c.(28-30)TTC>TTA	p.F10L	ZNF534_uc002pzj.1_Missense_Mutation_p.F10L|ZNF534_uc010epo.1_Missense_Mutation_p.F10L|ZNF534_uc002pzl.2_Missense_Mutation_p.F10L	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATTGTCATTCAGCGATGTGG	0.443		NaN											1	0	4.7546e-09	0.004007	4.92952e-09	13	159									
ZNF578	147660	broad.mit.edu	37	19	53014288	53014288	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:53014288C>G	uc002pzp.3	+	6	898	c.654C>G	c.(652-654)CTC>CTG	p.L218L		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	133	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		CATCATTACTCACACAAAAAC	0.348		NaN											0	0	0	0.004656	0	27	213									
ZNF320	162967	broad.mit.edu	37	19	53384869	53384869	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:53384869G>C	uc002qag.2	-	4	701	c.510C>G	c.(508-510)TTC>TTG	p.F170L	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.F116L|ZNF320_uc002qai.2_Missense_Mutation_p.F170L	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	170	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		ATTTGCAACTGAAAACTTTCT	0.358		NaN											0	0	0	0.003163	0	15	205									
ZNF347	84671	broad.mit.edu	37	19	53644301	53644301	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:53644301C>T	uc002qbb.1	-	5	1849	c.1780G>A	c.(1780-1782)GAG>AAG	p.E594K	ZNF347_uc010eql.1_Missense_Mutation_p.E595K|ZNF347_uc002qbc.1_Missense_Mutation_p.E595K	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	594					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TAAGGTTTCTCTCCAGTATGA	0.398		NaN											0	0	0	0.011902	0	46	353									
ZNF347	84671	broad.mit.edu	37	19	53656992	53656992	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:53656992G>A	uc002qbb.1	-	2	78	c.9C>T	c.(7-9)CTC>CTT	p.L3L	ZNF347_uc010eql.1_Silent_p.L3L|ZNF347_uc002qbc.1_Silent_p.L3L	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	3					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		TTACCTGGGTGAGAGCCATGC	0.398		NaN											0	0	0	0.010818	0	28	238									
CACNG8	59283	broad.mit.edu	37	19	54483190	54483190	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54483190T>G	uc002qcs.1	+	3	540	c.434T>G	c.(433-435)GTG>GGG	p.V145G	MIR935_hsa-mir-935|MI0005757_5'Flank	NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	146	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		GGTGTGTGCGTGGCGGCCTCC	0.647		NaN											0	0	0	0.00308	0	7	17									
PRPF31	26121	broad.mit.edu	37	19	54628017	54628017	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54628017C>T	uc002qdh.2	+	8	1233	c.837C>T	c.(835-837)ATC>ATT	p.I279I	PRPF31_uc010yek.1_Silent_p.I279I	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	279	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding	p.I279I(1)		ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACAGTGACATCGTGCAGTCCC	0.672		NaN											0	0	0	0.001984	0	7	64									
CNOT3	4849	broad.mit.edu	37	19	54649696	54649696	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54649696G>T	uc002qdj.1	+	9	1065	c.754G>T	c.(754-756)GAG>TAG	p.E252*	CNOT3_uc010yel.1_Nonsense_Mutation_p.E252*|CNOT3_uc002qdi.2_Nonsense_Mutation_p.E165*|CNOT3_uc002qdk.1_Nonsense_Mutation_p.E252*|CNOT3_uc010ere.1_RNA	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	252					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CATGGAGGATGAGATCTTCAA	0.642		NaN											1	0	1.10513e-12	0.014323	1.15629e-12	17	73									
TMC4	147798	broad.mit.edu	37	19	54664083	54664083	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54664083C>T	uc010erf.2	-	15	2231	c.2099G>A	c.(2098-2100)CGG>CAG	p.R700Q	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Missense_Mutation_p.R414Q|TMC4_uc002qdo.2_Missense_Mutation_p.R694Q	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	700	Cytoplasmic (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CACAGCGCGCCGTGCCAGGAA	0.572		NaN											0	0	0	0.009535	0	30	235									
TMC4	147798	broad.mit.edu	37	19	54666432	54666432	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54666432G>A	uc010erf.2	-	10	1626	c.1494C>T	c.(1492-1494)GTC>GTT	p.V498V	LENG1_uc002qdm.2_5'Flank|TMC4_uc002qdn.2_Silent_p.V212V|TMC4_uc002qdo.2_Silent_p.V492V	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	498	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGAGCAGCGCGACTGCCAAGA	0.547		NaN											0	0	0	0.009096	0	4	36									
LILRA5	353514	broad.mit.edu	37	19	54823808	54823808	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54823808G>A	uc002qfe.2	-	2	207	c.87C>T	c.(85-87)CTC>CTT	p.L29L	LILRA5_uc002qff.2_Silent_p.L29L|LILRA5_uc010yev.1_Silent_p.L29L|LILRA5_uc010yew.1_Silent_p.L29L|LILRA5_uc002qfh.1_Silent_p.L29L|LILRA5_uc002qfg.1_Silent_p.L29L	NM_021250	NP_067073	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor subfamily	29					innate immune response	extracellular region|integral to membrane	receptor activity			upper_aerodigestive_tract(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CAATCTCACCGAGGCAGAGCA	0.602		NaN											0	0	0	0.004482	0	8	71									
LENG9	94059	broad.mit.edu	37	19	54973372	54973372	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:54973372G>A	uc010yez.1	-	1	1523	c.1404C>T	c.(1402-1404)CTC>CTT	p.L468L		NM_198988	NP_945339	Q96B70	LENG9_HUMAN	leukocyte receptor cluster (LRC) member 9	468					RNA metabolic process	intracellular	catalytic activity|nucleic acid binding|zinc ion binding				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.134)		CTTCCTGGCTGAGGGTGAACT	0.647		NaN											0	0	0	0.01441	0	92	96									
NLRP2	55655	broad.mit.edu	37	19	55508802	55508802	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:55508802G>A	uc002qij.2	+	12	3083	c.2997G>A	c.(2995-2997)GTG>GTA	p.V999V	NLRP2_uc010yfp.1_Silent_p.V976V|NLRP2_uc010esn.2_Silent_p.V975V|NLRP2_uc010eso.2_Silent_p.V996V|NLRP2_uc010esp.2_Silent_p.V977V	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	999	LRR 7.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTAGTGGAGTGAAGATGCTGT	0.537		NaN											0	0	0	0.01441	0	187	158									
C19orf51	352909	broad.mit.edu	37	19	55670468	55670468	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:55670468G>A	uc002qji.1	-	12	1622	c.1588C>T	c.(1588-1590)CCG>TCG	p.P530S	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Missense_Mutation_p.P345S|C19orf51_uc002qjj.1_Missense_Mutation_p.P577S|C19orf51_uc002qjk.1_Missense_Mutation_p.P476S|C19orf51_uc002qjl.1_Missense_Mutation_p.P597S			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	530											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CAGTTGGGCGGAGCCAAGGCC	0.587		NaN											0	0	0	0.01441	0	52	31									
SYT5	6861	broad.mit.edu	37	19	55686347	55686347	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:55686347G>C	uc002qjm.1	-	6	1789	c.729C>G	c.(727-729)ATC>ATG	p.I243M	SYT5_uc002qjp.2_Missense_Mutation_p.I239M|SYT5_uc002qjn.1_Missense_Mutation_p.I243M|SYT5_uc002qjo.1_Missense_Mutation_p.I242M	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	243	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GGGAGAAGCAGATGTCCCCAA	0.607		NaN											0	0	0	0.01441	0	68	28									
UBE2S	27338	broad.mit.edu	37	19	55912936	55912936	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:55912936G>A	uc002qkx.1	-	4	905	c.537C>T	c.(535-537)TCC>TCT	p.S179S		NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	179					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		CAGGGTCGGTGGAGGAAGCTT	0.711		NaN											0	0	0	0.000602	0	3	30									
NLRP4	147945	broad.mit.edu	37	19	56369323	56369323	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:56369323C>A	uc002qmd.3	+	3	986	c.564C>A	c.(562-564)TTC>TTA	p.F188L	NLRP4_uc002qmf.2_Missense_Mutation_p.F113L|NLRP4_uc010etf.2_Missense_Mutation_p.F19L	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	188	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CGTTCTATTTCTGCTGCAGAG	0.507		NaN											1	0	1.01871e-10	0.008871	1.06177e-10	21	225									
ZNF71	58491	broad.mit.edu	37	19	57132856	57132856	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:57132856C>G	uc002qnm.3	+	3	439	c.201C>G	c.(199-201)CTC>CTG	p.L67L		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	67						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GGAACAAACTCTTAGGGGGCT	0.607		NaN											0	0	0	0.006214	0	9	73									
AURKC	6795	broad.mit.edu	37	19	57743573	57743573	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:57743573G>C	uc002qoe.2	+	3	466	c.277G>C	c.(277-279)GAG>CAG	p.E93Q	AURKC_uc002qoc.2_Missense_Mutation_p.E74Q|AURKC_uc002qod.2_Missense_Mutation_p.E59Q|AURKC_uc010etv.2_Missense_Mutation_p.E90Q	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	93	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		CCGGGAAATTGAGATCCAGGC	0.507		NaN											0	0	0	0.004482	0	8	97									
ZNF548	147694	broad.mit.edu	37	19	57911012	57911012	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:57911012G>C	uc002qom.2	+	3	1607	c.1357G>C	c.(1357-1359)GAG>CAG	p.E453Q	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.E456Q	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	453	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CGAGTGCAGAGAGTGTGGGAA	0.463		NaN											0	0	0	0.013537	0	13	113									
ZSCAN4	201516	broad.mit.edu	37	19	58187526	58187526	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58187526C>A	uc002qpu.2	+	3	710	c.13C>A	c.(13-15)CTA>ATA	p.L5I		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	5					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGCTTTAGATCTAAGAACCAT	0.398		NaN											1	0	2.94398e-08	0.007413	3.04067e-08	19	116									
ZNF417	147687	broad.mit.edu	37	19	58421054	58421054	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58421054C>T	uc002qqq.2	-	3	791	c.592G>A	c.(592-594)GAA>AAA	p.E198K	ZNF417_uc010yhm.1_Missense_Mutation_p.E155K|ZNF417_uc002qqr.2_Missense_Mutation_p.E197K	NM_152475	NP_689688	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		TGCATAGTTTCACTGTCTGTC	0.488		NaN											0	0	0	0.011902	0	37	69									
ZNF256	10172	broad.mit.edu	37	19	58452322	58452322	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58452322G>A	uc002qqu.2	-	3	2089	c.1854C>T	c.(1852-1854)CTC>CTT	p.L618L	ZNF256_uc010euj.2_Silent_p.L465L	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	618	C2H2-type 15.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GATGTTTTAGGAGGTTGGAGT	0.428		NaN											0	0	0	0.014323	0	21	74									
ZNF256	10172	broad.mit.edu	37	19	58453721	58453721	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58453721C>G	uc002qqu.2	-	3	690	c.455G>C	c.(454-456)AGA>ACA	p.R152T	ZNF256_uc010euj.2_5'UTR	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	152					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		AAACATGTCTCTGCCCCCATT	0.458		NaN											0	0	0	0.013726	0	34	100									
ZNF544	27300	broad.mit.edu	37	19	58773587	58773587	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:58773587C>G	uc010euo.2	+	7	2089	c.1615C>G	c.(1615-1617)CAG>GAG	p.Q539E	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.Q511E|ZNF544_uc010yhy.1_Missense_Mutation_p.Q511E|ZNF544_uc002qrt.3_Missense_Mutation_p.Q397E|ZNF544_uc002qru.3_Missense_Mutation_p.Q397E|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	539	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TATTACGCATCAGCGAATTCA	0.443		NaN											0	0	0	0.01441	0	57	52									
MYT1L	23040	broad.mit.edu	37	2	1893096	1893096	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:1893096C>T	uc002qxe.2	-	16	3264	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	MYT1L_uc002qxd.2_Missense_Mutation_p.E811K|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	813					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CAGTCGCCCTCGCCCAGCTGG	0.587		NaN											0	0	0	0.00278	0	23	92									
ASAP2	8853	broad.mit.edu	37	2	9540887	9540887	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:9540887G>A	uc002qzh.2	+	26	3091	c.2751G>A	c.(2749-2751)ACG>ACA	p.T917T	ASAP2_uc002qzi.2_Silent_p.T872T	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	917	Pro-rich.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						TCTCTGCAACGGAAGCTCTGG	0.532		NaN											0	0	0	0.010729	0	11	62									
ITGB1BP1	9270	broad.mit.edu	37	2	9552439	9552439	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:9552439C>G	uc002qzj.2	-	4	424	c.247G>C	c.(247-249)GAA>CAA	p.E83Q	ITGB1BP1_uc002qzk.2_Missense_Mutation_p.E83Q|ITGB1BP1_uc002qzl.2_RNA|ITGB1BP1_uc002qzm.2_RNA|ITGB1BP1_uc010yiy.1_Missense_Mutation_p.E39Q|ITGB1BP1_uc002qzn.1_Missense_Mutation_p.E83Q	NM_004763	NP_004754	O14713	ITBP1_HUMAN	integrin cytoplasmic domain-associated protein 1	83	PID.				cell migration|cell-matrix adhesion|intracellular protein kinase cascade	cytosol|lamellipodium|membrane|ruffle	protein binding|protein binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.23)		AATGGCCCTTCAAGGCCTTTT	0.403		NaN											0	0	0	0.00278	0	25	124									
ADAM17	6868	broad.mit.edu	37	2	9695720	9695720	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:9695720G>A	uc002qzu.2	-	1	198	c.15C>T	c.(13-15)CTC>CTT	p.L5L	ADAM17_uc010ewy.2_Silent_p.L5L|ADAM17_uc010ewz.2_Silent_p.L5L|ADAM17_uc010exb.1_Silent_p.L5L|ADAM17_uc002qzv.2_Silent_p.L5L	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	5					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TCAGGAATAGGAGAGACTGCC	0.647		NaN									OREG0014419	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	3	10									
GRHL1	29841	broad.mit.edu	37	2	10101494	10101494	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:10101494C>T	uc002raa.2	+	4	769	c.598C>T	c.(598-600)CAA>TAA	p.Q200*	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Silent_p.L36L|GRHL1_uc010yjb.1_Nonsense_Mutation_p.Q49*	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	200					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		CTCTGGTGCTCAAGCCCCAAA	0.522		NaN											0	0	0	0.009718	0	40	143									
KLF11	8462	broad.mit.edu	37	2	10187963	10187963	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:10187963C>T	uc002raf.1	+	3	661	c.499C>T	c.(499-501)CCC>TCC	p.P167S	KLF11_uc010yjc.1_Missense_Mutation_p.P150S	NM_003597	NP_003588	O14901	KLF11_HUMAN	Kruppel-like factor 11	167					apoptosis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|regulation of transcription involved in S phase of mitotic cell cycle	nucleus	sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.133)|OV - Ovarian serous cystadenocarcinoma(76;0.228)		GCCCAGCTCTCCCTGCAGGGC	0.637		NaN											0	0	0	0.014323	0	23	79									
HPCAL1	3241	broad.mit.edu	37	2	10559935	10559935	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:10559935G>A	uc002raj.2	+	3	426	c.52G>A	c.(52-54)GAG>AAG	p.E18K	HPCAL1_uc002rak.2_Missense_Mutation_p.E18K|HPCAL1_uc002ral.2_Missense_Mutation_p.E18K|HPCAL1_uc010exe.2_RNA|HPCAL1_uc010exf.2_Missense_Mutation_p.E18K	NM_002149	NP_002140	P37235	HPCL1_HUMAN	hippocalcin-like 1	18							calcium ion binding			pancreas(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.214)		GGACCTGCGGGAGAACACGGA	0.647		NaN											0	0	0	0.013726	0	31	10									
LPIN1	23175	broad.mit.edu	37	2	11964910	11964910	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:11964910C>T	uc010yjn.1	+	21	2940	c.2666C>T	c.(2665-2667)TCA>TTA	p.S889L	LPIN1_uc010yjm.1_Missense_Mutation_p.S974L|LPIN1_uc002rbt.2_Missense_Mutation_p.S889L|LPIN1_uc010yjo.1_Missense_Mutation_p.S390L	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	889					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CATTCTGCCTCAGCGTAAAAT	0.517		NaN											0	0	0	0.01441	0	63	34									
NBAS	51594	broad.mit.edu	37	2	15415689	15415689	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:15415689C>T	uc002rcc.1	-	44	5669	c.5643G>A	c.(5641-5643)ATG>ATA	p.M1881I	NBAS_uc010exl.1_Missense_Mutation_p.M953I|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1881										ovary(2)|liver(1)|skin(1)	4						CAAAGTACTTCATGCAGACAT	0.448		NaN											0	0	0	0.01441	0	65	25									
APOB	338	broad.mit.edu	37	2	21233209	21233209	+	Silent	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:21233209A>G	uc002red.2	-	26	6659	c.6531T>C	c.(6529-6531)TAT>TAC	p.Y2177Y		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2177	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATTGTATCATATATGTCTGCA	0.234		NaN											0	0	0	0.01441	0	50	31									
APOB	338	broad.mit.edu	37	2	21233218	21233218	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:21233218C>T	uc002red.2	-	26	6650	c.6522G>A	c.(6520-6522)CTG>CTA	p.L2174L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2174	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TATATGTCTGCAGTTGAGATA	0.254		NaN											0	0	0	0.01441	0	45	31									
MFSD2B	388931	broad.mit.edu	37	2	24236211	24236211	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:24236211G>A	uc002reo.1	+	2	167	c.153G>A	c.(151-153)GGG>GGA	p.G51G	MFSD2B_uc010exz.1_RNA	NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	51					transport	integral to membrane				ovary(2)	2						GCATTGGTGGGGTCCCCAACC	0.547		NaN											0	0	0	0.000602	0	5	19									
C2orf84	653140	broad.mit.edu	37	2	24398440	24398440	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:24398440G>C	uc002rfc.2	+	2	177	c.91G>C	c.(91-93)GAG>CAG	p.E31Q	C2orf84_uc010eyc.2_RNA	NM_001040710	NP_001035800	Q86W67	CB084_HUMAN	hypothetical protein LOC653140	31											0						TTCTTTAATGGAGGTGAGATA	0.483		NaN											0	0	0	0.009535	0	32	30									
ADCY3	109	broad.mit.edu	37	2	25047259	25047259	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:25047259C>T	uc002rfs.3	-	16	2923	c.2724G>A	c.(2722-2724)AAG>AAA	p.K908K	ADCY3_uc002rfr.3_Silent_p.K495K|ADCY3_uc010ykm.1_Silent_p.K909K	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	908	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CATCTCTCTTCTTGGACCCCA	0.582		NaN											0	0	0	0.006999	0	40	27									
DTNB	1838	broad.mit.edu	37	2	25705718	25705718	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:25705718C>T	uc002rgh.2	-	10	1276	c.1026G>A	c.(1024-1026)ATG>ATA	p.M342I	DTNB_uc002rgg.2_Missense_Mutation_p.M1I|DTNB_uc010yko.1_Missense_Mutation_p.M285I|DTNB_uc010ykp.1_Missense_Mutation_p.M138I|DTNB_uc002rgo.2_Missense_Mutation_p.M163I|DTNB_uc002rgi.2_Missense_Mutation_p.M342I|DTNB_uc002rgj.2_Missense_Mutation_p.M342I|DTNB_uc002rgk.2_Missense_Mutation_p.M342I|DTNB_uc002rgl.2_Missense_Mutation_p.M342I|DTNB_uc002rgq.2_Missense_Mutation_p.M342I|DTNB_uc002rgm.2_Missense_Mutation_p.M342I|DTNB_uc002rgn.2_Missense_Mutation_p.M138I|DTNB_uc002rgr.1_Missense_Mutation_p.M331I|DTNB_uc010ykq.1_Missense_Mutation_p.M195I	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	342						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGTGTCATTCATATTAGTCA	0.468		NaN											0	0	0	0.01441	0	45	29									
ASXL2	55252	broad.mit.edu	37	2	26029124	26029124	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:26029124C>T	uc002rgs.2	-	3	447	c.226G>A	c.(226-228)GGT>AGT	p.G76S		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	76					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCATTCTACCTGGAACCTTA	0.398		NaN											0	0	0	0.000602	0	5	36									
OTOF	9381	broad.mit.edu	37	2	26726693	26726693	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:26726693G>A	uc002rhk.2	-	6	657	c.530C>T	c.(529-531)TCC>TTC	p.S177F	OTOF_uc010ylb.1_RNA	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	177	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTCATGGCGGAGAACACGCT	0.632		NaN											0	0	0	0.003163	0	16	77									
TMEM214	54867	broad.mit.edu	37	2	27258840	27258840	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27258840G>A	uc002ria.3	+	5	750	c.640G>A	c.(640-642)GAG>AAG	p.E214K	TMEM214_uc010yle.1_RNA|TMEM214_uc002rib.3_Missense_Mutation_p.E169K	NM_017727	NP_060197	Q6NUQ4	TM214_HUMAN	transmembrane protein 214 isoform 1	214						integral to membrane	protein binding				0						CTCTCCAGGGGAGTCACTACA	0.527		NaN											0	0	0	0.00245	0	12	81									
SLC5A6	8884	broad.mit.edu	37	2	27427346	27427346	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27427346G>C	uc002rjd.2	-	9	1379	c.988C>G	c.(988-990)CAG>GAG	p.Q330E	SLC5A6_uc010eyv.1_Missense_Mutation_p.Q330E	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	330					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	GGGGCTGCCTGAGCCTGCTGA	0.572		NaN											0	0	0	0.00245	0	14	73									
SLC5A6	8884	broad.mit.edu	37	2	27430496	27430496	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27430496G>T	uc002rjd.2	-	3	414	c.23C>A	c.(22-24)TCA>TAA	p.S8*	SLC5A6_uc010eyv.1_Nonsense_Mutation_p.S8*|SLC5A6_uc002rje.1_Nonsense_Mutation_p.S8*	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	8					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	AAGAGGGGCTGAGGTGCTCAC	0.587		NaN											1	0	1.58986e-06	0.008291	1.63198e-06	10	57									
CAD	790	broad.mit.edu	37	2	27463781	27463781	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27463781G>A	uc002rji.2	+	36	5758	c.5596G>A	c.(5596-5598)GAG>AAG	p.E1866K	CAD_uc010eyw.2_Missense_Mutation_p.E1803K	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	1866	Linker.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GTTTGCAGCTGAGGAGCCAAA	0.502		NaN											0	0	0	0.003954	0	27	22									
PPM1G	5496	broad.mit.edu	37	2	27605009	27605009	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:27605009G>A	uc002rkl.2	-	10	1525	c.1418C>T	c.(1417-1419)TCA>TTA	p.S473L	ZNF513_uc002rkj.2_5'Flank|ZNF513_uc002rkk.2_5'Flank|PPM1G_uc002rkm.2_Missense_Mutation_p.S254L	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	473					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					CACAATGGATGACAATAACCG	0.483		NaN											0	0	0	0.004007	0	16	71									
BRE	9577	broad.mit.edu	37	2	28152708	28152708	+	Silent	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:28152708A>G	uc002rlr.2	+	4	456	c.138A>G	c.(136-138)TCA>TCG	p.S46S	BRE_uc002rlp.1_Silent_p.S46S|BRE_uc002rlq.2_Silent_p.S46S|BRE_uc002rls.2_Silent_p.S46S|BRE_uc002rlt.2_Silent_p.S46S|BRE_uc002rlu.2_Silent_p.S46S|BRE_uc002rlv.2_5'UTR	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A	46	UEV-like 1.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GCTGCACATCATTGACTCCTG	0.323		NaN											0	0	0	0.004656	0	25	109									
C2orf71	388939	broad.mit.edu	37	2	29295005	29295005	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:29295005G>C	uc002rmt.1	-	1	2123	c.2123C>G	c.(2122-2124)TCA>TGA	p.S708*		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	708					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						GACCTCTCCTGATGGGATGGC	0.507		NaN											0	0	0	0.010504	0	19	135									
CLIP4	79745	broad.mit.edu	37	2	29354254	29354254	+	Silent	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:29354254T>C	uc002rmv.2	+	3	503	c.264T>C	c.(262-264)ATT>ATC	p.I88I	CLIP4_uc002rmu.2_Silent_p.I88I|CLIP4_uc010ezm.1_Silent_p.I88I|CLIP4_uc002rmw.2_RNA|CLIP4_uc010ymn.1_Silent_p.I70I	NM_024692	NP_078968	Q8N3C7	CLIP4_HUMAN	CAP-GLY domain containing linker protein family,	88	ANK 1.									ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					TTGACATTATTGGAAATGAGG	0.338		NaN											0	0	0	0.001168	0	6	189									
XDH	7498	broad.mit.edu	37	2	31587029	31587029	+	Nonsense_Mutation	SNP	G	G	A	rs140982129		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:31587029G>A	uc002rnv.1	-	24	2705	c.2626C>T	c.(2626-2628)CAG>TAG	p.Q876*		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	876					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	CTCACACTCTGAGAGAGATCC	0.572		NaN											0	0	0	0.00308	0	8	54									
BIRC6	57448	broad.mit.edu	37	2	32640622	32640622	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:32640622G>A	uc010ezu.2	+	10	2397	c.2263G>A	c.(2263-2265)GAA>AAA	p.E755K		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	755					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					ATGCCCTGTTGAATCCTTGAG	0.398		NaN											0	0	0	0.00245	0	14	79									
BIRC6	57448	broad.mit.edu	37	2	32743450	32743450	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:32743450C>T	uc010ezu.2	+	56	11613	c.11479C>T	c.(11479-11481)CAG>TAG	p.Q3827*		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3827					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					AATGTTTCTTCAGTCTCCATG	0.368		NaN											0	0	0	0.003163	0	15	79									
BIRC6	57448	broad.mit.edu	37	2	32770731	32770731	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:32770731C>T	uc010ezu.2	+	63	12748	c.12614C>T	c.(12613-12615)TCA>TTA	p.S4205L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	4205					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CAATCTCCATCAGCCAATGTG	0.393		NaN											0	0	0	0.01441	0	56	288									
GALM	130589	broad.mit.edu	37	2	38960689	38960689	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:38960689C>T	uc002rqy.2	+	7	1263	c.1011C>T	c.(1009-1011)TTC>TTT	p.F337F		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	337					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				CCACCTGGTTCAAGTTTTCTG	0.527		NaN											0	0	0	0.01441	0	88	104									
SLC3A1	6519	broad.mit.edu	37	2	44539852	44539852	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:44539852G>A	uc002ruc.3	+	8	1538	c.1460G>A	c.(1459-1461)GGA>GAA	p.G487E	SLC3A1_uc002rtz.2_Missense_Mutation_p.G487E|SLC3A1_uc002rua.2_Missense_Mutation_p.G487E|SLC3A1_uc002rub.2_Missense_Mutation_p.G487E|SLC3A1_uc002rud.3_Missense_Mutation_p.G209E|SLC3A1_uc002rue.3_Missense_Mutation_p.G107E	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	487	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	ATTGGAATGGGAAATATTGTA	0.353		NaN											0	0	0	0.006214	0	9	65									
ERLEC1	27248	broad.mit.edu	37	2	54028617	54028617	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:54028617G>A	uc002rxl.2	+	7	889	c.609G>A	c.(607-609)CAG>CAA	p.Q203Q	ASB3_uc002rxi.3_Intron|ERLEC1_uc002rxm.2_Silent_p.Q203Q|ERLEC1_uc002rxn.2_Silent_p.Q203Q	NM_015701	NP_056516	Q96DZ1	ERLEC_HUMAN	erlectin isoform 1	203					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			ovary(2)	2						GTTTGAAACAGAACCGGCCCA	0.373		NaN											0	0	0	0.01441	0	47	88									
SPTBN1	6711	broad.mit.edu	37	2	54882285	54882285	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:54882285C>T	uc002rxu.2	+	28	6150	c.5901C>T	c.(5899-5901)TTC>TTT	p.F1967F	SPTBN1_uc002rxx.2_Silent_p.F1954F|SPTBN1_uc002rxy.2_Silent_p.F112F|SPTBN1_uc010you.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1967	Spectrin 16.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ATGACAGTTTCACAACCTGCA	0.423		NaN											0	0	0	0.001855	0	14	67									
RTN4	57142	broad.mit.edu	37	2	55252388	55252388	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:55252388G>C	uc002rye.2	-	3	3145	c.2847C>G	c.(2845-2847)CTC>CTG	p.L949L	RTN4_uc002ryd.2_Silent_p.L743L|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	949	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						GAGGCAATAAGAGCACCTTTG	0.393		NaN											0	0	0	0.01441	0	94	92									
RTN4	57142	broad.mit.edu	37	2	55253818	55253818	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:55253818C>T	uc002rye.2	-	3	1715	c.1417G>A	c.(1417-1419)GAG>AAG	p.E473K	RTN4_uc002ryd.2_Missense_Mutation_p.E267K|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	473	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						GCAATGCTCTCAGTTGCTGCT	0.388		NaN											0	0	0	0.01441	0	131	215									
MTIF2	4528	broad.mit.edu	37	2	55471226	55471226	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:55471226C>T	uc002ryn.2	-	12	1987	c.1250G>A	c.(1249-1251)GGA>GAA	p.G417E	MTIF2_uc010yox.1_Missense_Mutation_p.G86E|MTIF2_uc002ryo.2_Missense_Mutation_p.G417E	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	417					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						GCCTGTAATTCCCACTGGCAT	0.393		NaN											0	0	0	0.01441	0	47	40									
BCL11A	53335	broad.mit.edu	37	2	60688925	60688925	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:60688925G>C	uc002sae.1	-	4	1350	c.1122C>G	c.(1120-1122)GTC>GTG	p.V374V	BCL11A_uc002sab.2_Silent_p.V374V|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Silent_p.V340V|BCL11A_uc002sad.1_Silent_p.V222V|BCL11A_uc002saf.1_Silent_p.V340V	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	374					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			ACTTGGACTTGACCGGGGGCT	0.632		NaN	T	IGH@	B-CLL								0	0	0	0.008361	0	30	80									
B3GNT2	10678	broad.mit.edu	37	2	62449761	62449761	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:62449761G>C	uc002sbs.2	+	2	644	c.406G>C	c.(406-408)GAT>CAT	p.D136H		NM_006577	NP_006568	Q9NY97	B3GN2_HUMAN	UDP-GlcNAc:betaGal	136	Lumenal (Potential).					Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1	Lung NSC(7;0.031)|all_lung(7;0.0634)		LUSC - Lung squamous cell carcinoma(7;3.55e-06)|Epithelial(17;0.0963)			AGATCAGCCGGATAAGTGTGC	0.463		NaN											0	0	0	0.013114	0	44	257									
OTX1	5013	broad.mit.edu	37	2	63282997	63282997	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:63282997C>T	uc002scd.2	+	5	859	c.611C>T	c.(610-612)TCG>TTG	p.S204L	OTX1_uc010ypt.1_Missense_Mutation_p.S138L	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	204						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					AGCAACACCTCGTGTATGCAG	0.682		NaN											0	0	0	0.008291	0	4	4									
AFTPH	54812	broad.mit.edu	37	2	64796344	64796344	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:64796344C>T	uc002sdc.2	+	3	2238	c.2206C>T	c.(2206-2208)CGA>TGA	p.R736*	AFTPH_uc002scz.2_Nonsense_Mutation_p.R736*|AFTPH_uc002sda.2_Nonsense_Mutation_p.R736*|AFTPH_uc002sdb.2_Nonsense_Mutation_p.R736*	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	736					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						AATAGACACCCGAAACATTGT	0.418		NaN											0	0	0	0.012319	0	21	138									
GFPT1	2673	broad.mit.edu	37	2	69569358	69569358	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:69569358G>C	uc002sfh.2	-	12	1254	c.1075C>G	c.(1075-1077)CAC>GAC	p.H359D		NM_002056	NP_002047	Q06210	GFPT1_HUMAN	glucosamine-fructose-6-phosphate	377	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			skin(1)	1						TCCTTTATGTGATCCTTCAAA	0.358		NaN											0	0	0	0.01441	0	48	232									
PCBP1	5093	broad.mit.edu	37	2	70315543	70315543	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:70315543C>T	uc002sgf.2	+	1	959	c.668C>T	c.(667-669)TCG>TTG	p.S223L	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	223					nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						GATGCCTACTCGATTCAAGGA	0.607		NaN											0	0	0	0.00278	0	23	29									
NAGK	55577	broad.mit.edu	37	2	71297643	71297643	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:71297643G>A	uc002shp.3	+	2	447	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	NAGK_uc010fea.2_RNA|NAGK_uc002shq.3_5'UTR|NAGK_uc002shr.2_5'UTR	NM_017567	NP_060037	Q9UJ70	NAGK_HUMAN	N-Acetylglucosamine kinase	14					N-acetylglucosamine metabolic process|N-acetylmannosamine metabolic process		ATP binding|N-acetylglucosamine kinase activity|protein binding				0					N-Acetyl-D-glucosamine(DB00141)	GGAGGCACACGATCCGAGGTC	0.527		NaN									OREG0014689	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	10	35									
CCDC142	84865	broad.mit.edu	37	2	74709391	74709391	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:74709391C>T	uc002slr.2	-	1	967	c.574G>A	c.(574-576)GAG>AAG	p.E192K	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Missense_Mutation_p.E192K|CCDC142_uc002slp.2_Missense_Mutation_p.E192K	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	192										central_nervous_system(1)	1						CTGGCGGGCTCCCGGCCGAGA	0.667		NaN											0	0	0	0.001168	0	6	9									
SEMA4F	10505	broad.mit.edu	37	2	74883774	74883774	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:74883774G>C	uc002sna.1	+	2	370	c.259G>C	c.(259-261)GCT>CCT	p.A87P	SEMA4F_uc010ysb.1_Missense_Mutation_p.A87P|SEMA4F_uc010ffq.1_Missense_Mutation_p.A87P|SEMA4F_uc010ffr.1_5'UTR|SEMA4F_uc002snb.1_5'UTR|SEMA4F_uc002snc.1_Missense_Mutation_p.A87P	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	87	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CACCATCTTCGCTTTATCCCT	0.527		NaN											0	0	0	0.01441	0	54	80									
C2orf89	129293	broad.mit.edu	37	2	85108116	85108116	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:85108116G>C	uc010ysl.1	-	1	137	c.48C>G	c.(46-48)CCC>CCG	p.P16P	C2orf89_uc002sou.3_Silent_p.P16P|C2orf89_uc010fgc.1_Silent_p.P16P	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	16						integral to membrane				ovary(1)	1						CTGCGCCCGTGGGCAGGAGGC	0.711		NaN											0	0	0	0.004482	0	7	3									
ELMOD3	84173	broad.mit.edu	37	2	85616934	85616934	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:85616934G>A	uc002spf.3	+	13	1464	c.799G>A	c.(799-801)GAG>AAG	p.E267K	ELMOD3_uc002spg.3_Missense_Mutation_p.E267K|ELMOD3_uc002sph.3_Missense_Mutation_p.E267K|ELMOD3_uc010ysn.1_Missense_Mutation_p.E267K|ELMOD3_uc010yso.1_RNA|ELMOD3_uc010ysp.1_RNA	NM_001135021	NP_001128493	Q96FG2	ELMD3_HUMAN	ELMO/CED-12 domain containing 3 isoform b	267	ELMO.				phagocytosis	cytoskeleton				ovary(2)	2						GGCCTTGAGAGAGGAGTGTCT	0.542		NaN											0	0	0	0.003755	0	33	40									
SH2D6	284948	broad.mit.edu	37	2	85662187	85662187	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:85662187G>A	uc002spq.2	+	1	270	c.109G>A	c.(109-111)GAA>AAA	p.E37K	SH2D6_uc002spo.2_Splice_Site|SH2D6_uc002spp.2_Splice_Site	NM_198482	NP_940884	Q7Z4S9	SH2D6_HUMAN	SH2 domain containing 6	37										central_nervous_system(1)	1						GCTTCTTCTAGAAGGAAGGAA	0.512		NaN											0	0	0	0.006214	0	10	23									
POLR1A	25885	broad.mit.edu	37	2	86259451	86259451	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:86259451C>T	uc002sqs.2	-	29	4595	c.4216G>A	c.(4216-4218)GAG>AAG	p.E1406K	POLR1A_uc010ytb.1_Missense_Mutation_p.E772K	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1406					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						TCCCCCTCCTCAGCTTCAGCA	0.567		NaN											0	0	0	0.00623	0	40	54									
PTCD3	55037	broad.mit.edu	37	2	86333455	86333455	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:86333455G>A	uc002sqw.2	+	1	151	c.85G>A	c.(85-87)GAA>AAA	p.E29K	POLR1A_uc002sqs.2_5'Flank|POLR1A_uc002sqv.2_5'Flank|PTCD3_uc010ytc.1_RNA	NM_017952	NP_060422	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3 precursor	29						mitochondrion	protein binding			ovary(1)	1						GGGTTTGTGTGAACAGGCACG	0.597		NaN											0	0	0	0.014323	0	17	47									
KRCC1	51315	broad.mit.edu	37	2	88327938	88327938	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:88327938C>T	uc002sso.1	-	4	539	c.145G>A	c.(145-147)GAG>AAG	p.E49K	KRCC1_uc002ssp.1_Missense_Mutation_p.E49K	NM_016618	NP_057702	Q9NPI7	KRCC1_HUMAN	lysine-rich coiled-coil 1	49										ovary(1)	1						GAATTAACCTCTCCTTTGTAC	0.418		NaN											0	0	0	0.01441	0	52	93									
PROM2	150696	broad.mit.edu	37	2	95940393	95940393	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:95940393G>A	uc002suh.1	+	1	193	c.60G>A	c.(58-60)CTG>CTA	p.L20L	PROM2_uc002sui.2_Silent_p.L20L|PROM2_uc002suj.2_5'UTR|PROM2_uc002suk.2_Silent_p.L20L|PROM2_uc002sul.2_5'UTR	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	20						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						GGCTGGCCCTGAGTCAGCTGG	0.677		NaN											0	0	0	0.008291	0	10	65									
PROM2	150696	broad.mit.edu	37	2	95940456	95940456	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:95940456C>T	uc002suh.1	+	1	256	c.123C>T	c.(121-123)TTC>TTT	p.F41F	PROM2_uc002sui.2_Silent_p.F41F|PROM2_uc002suj.2_5'UTR|PROM2_uc002suk.2_Silent_p.F41F|PROM2_uc002sul.2_5'UTR	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	41	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						ACCTGACATTCACCCCAGCAG	0.697		NaN											0	0	0	0.013114	0	42	147									
FAHD2A	51011	broad.mit.edu	37	2	96072879	96072879	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:96072879G>T	uc002sur.2	+	3	615	c.436G>T	c.(436-438)GAG>TAG	p.E146*	FAHD2A_uc002sus.2_Nonsense_Mutation_p.E146*	NM_016044	NP_057128	Q96GK7	FAH2A_HUMAN	fumarylacetoacetate hydrolase domain containing	146							hydrolase activity|metal ion binding			ovary(1)	1						GCCCTATGATGAGGTGGTCCT	0.562		NaN											1	0	9.05144e-12	0.001855	9.45218e-12	10	124									
ARID5A	10865	broad.mit.edu	37	2	97215120	97215120	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:97215120C>T	uc002swe.2	+	3	283	c.183C>T	c.(181-183)TTC>TTT	p.F61F	ARID5A_uc010yuq.1_5'UTR|ARID5A_uc002swf.2_Intron|ARID5A_uc002swg.2_Intron	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	61	ARID.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						agcaggCCTTCCTGGTCAGCC	0.478		NaN											0	0	0	0.008361	0	28	46									
EIF5B	9669	broad.mit.edu	37	2	99976974	99976974	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:99976974C>G	uc002tab.2	+	3	392	c.208C>G	c.(208-210)CAA>GAA	p.Q70E		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	70					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TTTGGAAGCTCAAGGCATCAA	0.348		NaN											0	0	0	0.007413	0	19	44									
EIF5B	9669	broad.mit.edu	37	2	99984993	99984993	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:99984993G>A	uc002tab.2	+	7	1510	c.1326G>A	c.(1324-1326)AAG>AAA	p.K442K		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	442					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TGCCAAAGAAGAGGCCAATTT	0.343		NaN											0	0	0	0.003755	0	35	63									
TBC1D8	11138	broad.mit.edu	37	2	101648738	101648738	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:101648738C>T	uc010fiv.2	-	11	2014	c.1883G>A	c.(1882-1884)CGA>CAA	p.R628Q	TBC1D8_uc002tau.3_Missense_Mutation_p.R385Q	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	628	Rab-GAP TBC.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						ACCGATCACTCGGTGGTTGAA	0.532		NaN											0	0	0	0.004482	0	9	12									
C2orf49	79074	broad.mit.edu	37	2	105959589	105959589	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:105959589C>T	uc002tcs.1	+	3	583	c.551C>T	c.(550-552)TCA>TTA	p.S184L	C2orf49_uc010fjd.1_Missense_Mutation_p.S142L	NM_024093	NP_076998	Q9BVC5	ASHWN_HUMAN	ashwin	184						tRNA-splicing ligase complex					0						AAAAGTCCTTCAGGCCCTGTG	0.443		NaN											0	0	0	0.005524	0	40	73									
SLC5A7	60482	broad.mit.edu	37	2	108608600	108608600	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:108608600G>A	uc002tdv.2	+	3	493	c.217G>A	c.(217-219)GAA>AAA	p.E73K	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.E73K|SLC5A7_uc010ywn.1_5'UTR	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	73	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TGGCACAGCTGAAGCAGTTTA	0.423		NaN											0	0	0	0.003755	0	34	53									
RANBP2	5903	broad.mit.edu	37	2	109352069	109352069	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:109352069G>C	uc002tem.3	+	5	613	c.487G>C	c.(487-489)GAT>CAT	p.D163H		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	163					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TGTAAGACCTGATGACGTCCA	0.438		NaN											0	0	0	0.01441	0	102	410									
RANBP2	5903	broad.mit.edu	37	2	109383083	109383083	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:109383083G>A	uc002tem.3	+	20	6214	c.6088G>A	c.(6088-6090)GAA>AAA	p.E2030K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2030	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AACAGGAGAAGAAGATGAAAA	0.388		NaN											0	0	0	0.01441	0	134	630									
SEPT10	151011	broad.mit.edu	37	2	110332307	110332307	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:110332307C>T	uc002tew.2	-	5	830	c.451G>A	c.(451-453)GAG>AAG	p.E151K	SEPT10_uc010ywu.1_Intron|SEPT10_uc002tex.2_Missense_Mutation_p.E128K|SEPT10_uc002tey.2_Missense_Mutation_p.E151K|SEPT10_uc010ywv.1_Missense_Mutation_p.E17K|SEPT10_uc002tev.1_5'UTR|SEPT10_uc010fjo.2_RNA	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	151					cell cycle|cell division	septin complex	GTP binding				0						AGATAGGCCTCAAACTGAGCA	0.378		NaN											0	0	0	0.01441	0	49	67									
ANAPC1	64682	broad.mit.edu	37	2	112550062	112550062	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:112550062G>A	uc002thi.2	-	38	4836	c.4589C>T	c.(4588-4590)TCA>TTA	p.S1530L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1530	PC 4.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						TAGGTTTCCTGAGCCAGCCAT	0.483		NaN											0	0	0	0.004007	0	12	45									
MERTK	10461	broad.mit.edu	37	2	112751899	112751899	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:112751899G>A	uc002thk.1	+	9	1490	c.1368G>A	c.(1366-1368)ACG>ACA	p.T456T	MERTK_uc002thl.1_Silent_p.T280T	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	456	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						ACAATGCTACGTGCACAGTGA	0.522		NaN											0	0	0	0.01441	0	71	109									
FOXD4L1	200350	broad.mit.edu	37	2	114256945	114256945	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:114256945G>A	uc002tjw.3	+	1	285	c.112G>A	c.(112-114)GAG>AAG	p.E38K		NM_012184	NP_036316	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	38					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						agatgaagacgaggtggaaga	0.532		NaN											0	0	0	0.01441	0	48	63									
EN1	2019	broad.mit.edu	37	2	119604241	119604241	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:119604241G>A	uc002tlm.2	-	1	1519	c.503C>T	c.(502-504)TCG>TTG	p.S168L		NM_001426	NP_001417	Q05925	HME1_HUMAN	engrailed homeobox 1	168					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)	2						GCACAGGAGCGAGGCAGCGCC	0.602		NaN											0	0	0	0.00308	0	8	4									
CNTNAP5	129684	broad.mit.edu	37	2	125504879	125504879	+	Silent	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:125504879G>T	uc002tno.2	+	14	2512	c.2148G>T	c.(2146-2148)GGG>GGT	p.G716G	CNTNAP5_uc010flu.2_Silent_p.G717G	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	716	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCCCTCCTGGGGTCCAGCAGT	0.517		NaN											1	0	6.4771e-29	0.010771	6.86965e-29	44	74									
UGGT1	56886	broad.mit.edu	37	2	128867254	128867254	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:128867254C>T	uc002tps.2	+	5	633	c.455C>T	c.(454-456)TCA>TTA	p.S152L	UGGT1_uc010fme.1_Missense_Mutation_p.S27L|UGGT1_uc002tpr.2_Missense_Mutation_p.S128L	NM_020120	NP_064505	Q9NYU2	UGGG1_HUMAN	UDP-glucose ceramide glucosyltransferase-like 1	152					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			ovary(1)	1						TCGTTTTTTTCAGTGCATGGA	0.378		NaN											0	0	0	0.01441	0	51	77									
HS6ST1	9394	broad.mit.edu	37	2	129026352	129026352	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:129026352G>A	uc002tpt.3	-	2	654	c.620C>T	c.(619-621)TCG>TTG	p.S207L		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	207	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		CATATGCAACGACGTCTTCCA	0.632		NaN											0	0	0	0.010729	0	12	58									
RAB3GAP1	22930	broad.mit.edu	37	2	135888197	135888197	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:135888197C>T	uc002tuj.2	+	13	1167	c.1142C>T	c.(1141-1143)TCA>TTA	p.S381L	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.S381L|RAB3GAP1_uc010fng.2_Missense_Mutation_p.S206L|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	381						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		TTATCAGTTTCAAATATGGTA	0.338		NaN											0	0	0	0.004007	0	16	51									
DARS	1615	broad.mit.edu	37	2	136743012	136743012	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:136743012C>T	uc002tux.1	-	1	211	c.27G>A	c.(25-27)AAG>AAA	p.K9K	DARS_uc010fnj.1_5'UTR	NM_001349	NP_001340	P14868	SYDC_HUMAN	aspartyl-tRNA synthetase	9					aspartyl-tRNA aminoacylation|protein complex assembly	cytosol|nuclear membrane|plasma membrane|soluble fraction	aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.168)	L-Aspartic Acid(DB00128)	TCTCCTGACTCTTGCGGCTGG	0.687		NaN											0	0	0	0.013537	0	5	1									
LRP1B	53353	broad.mit.edu	37	2	141359032	141359032	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:141359032C>T	uc002tvj.1	-	42	7948	c.6976G>A	c.(6976-6978)GAT>AAT	p.D2326N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2326	Extracellular (Potential).|LDL-receptor class B 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGACATTCATCCAAGGCTAGC	0.378		NaN								TSP Lung(27;0.18)			0	0	0	0.005524	0	38	10									
MBD5	55777	broad.mit.edu	37	2	149226996	149226996	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:149226996C>G	uc002twm.3	+	9	2472	c.1484C>G	c.(1483-1485)TCA>TGA	p.S495*	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Nonsense_Mutation_p.S495*|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	495						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TCACCAAGGTCAACAATAGGG	0.478		NaN											0	0	0	0.00499	0	18	36									
STAM2	10254	broad.mit.edu	37	2	153000393	153000393	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:153000393C>G	uc002tyc.3	-	7	1002	c.652G>C	c.(652-654)GAC>CAC	p.D218H	STAM2_uc010foa.1_Missense_Mutation_p.D218H|STAM2_uc002tyd.2_Missense_Mutation_p.D218H	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	218	SH3.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		AGTTCATTGTCCTCAACAGCT	0.318		NaN											0	0	0	0.008871	0	19	37									
LRP2	4036	broad.mit.edu	37	2	170148823	170148823	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:170148823G>A	uc002ues.2	-	7	922	c.709C>T	c.(709-711)CAA>TAA	p.Q237*	LRP2_uc010zdf.1_Nonsense_Mutation_p.Q237*	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	237	LDL-receptor class A 6.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCCAGTTTTGATAAATGCAT	0.453		NaN											0	0	0	0.00499	0	18	49									
TLK1	9874	broad.mit.edu	37	2	171913057	171913057	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:171913057G>C	uc002ugn.2	-	6	945	c.473C>G	c.(472-474)TCA>TGA	p.S158*	TLK1_uc002ugo.2_Nonsense_Mutation_p.S179*|TLK1_uc002ugp.2_Nonsense_Mutation_p.S110*|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Nonsense_Mutation_p.S62*|TLK1_uc002ugr.1_5'Flank	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	158					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						TACTGGACTTGAGCCATTTCC	0.373		NaN											0	0	0	0.00632	0	25	54									
MAP1D	254042	broad.mit.edu	37	2	172928454	172928454	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:172928454G>C	uc002uhk.2	+	3	287	c.214G>C	c.(214-216)GAC>CAC	p.D72H	MAP1D_uc010zdw.1_5'UTR	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	72					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			AAAGAAGCCAGACTATGTGAC	0.468		NaN											0	0	0	0.009096	0	3	24									
TTN	7273	broad.mit.edu	37	2	179604684	179604684	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:179604684C>T	uc010zfh.1	-	46	12987	c.12763G>A	c.(12763-12765)GAG>AAG	p.E4255K	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.E4188K|TTN_uc010zfj.1_Missense_Mutation_p.E4063K|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCTCGACCTCCACCTTTTCA	0.458		NaN											0	0	0	0.008361	0	31	67									
TTN	7273	broad.mit.edu	37	2	179606140	179606140	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:179606140G>C	uc010zfh.1	-	46	11531	c.11307C>G	c.(11305-11307)TTC>TTG	p.F3769L	TTN_uc010zfg.1_Intron|TTN_uc010zfi.1_Missense_Mutation_p.F3702L|TTN_uc010zfj.1_Missense_Mutation_p.F3577L|TTN_uc002umz.1_Intron	NM_133437	NP_597681	Q8WZ42	TITIN_HUMAN	titin isoform novex-2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCTTAAGGAAGTGAGGAG	0.458		NaN											0	0	0	0.01441	0	61	126									
TTN	7273	broad.mit.edu	37	2	179641337	179641337	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:179641337G>A	uc010zfg.1	-	28	5478	c.5254C>T	c.(5254-5256)CGT>TGT	p.R1752C	TTN_uc010zfh.1_Missense_Mutation_p.R1706C|TTN_uc010zfi.1_Missense_Mutation_p.R1706C|TTN_uc010zfj.1_Missense_Mutation_p.R1706C|TTN_uc002unb.2_Missense_Mutation_p.R1752C|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1752							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGATCATACGGAGCCTGTTG	0.483		NaN											0	0	0	0.00278	0	25	41									
SSFA2	6744	broad.mit.edu	37	2	182766801	182766801	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:182766801C>T	uc002uoi.2	+	8	1343	c.1021C>T	c.(1021-1023)CAA>TAA	p.Q341*	SSFA2_uc002uoh.2_Nonsense_Mutation_p.Q341*|SSFA2_uc002uoj.2_Nonsense_Mutation_p.Q341*|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Nonsense_Mutation_p.Q188*|SSFA2_uc002uol.2_Nonsense_Mutation_p.Q188*	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	341						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TAAAAACGATCAAAAGTCTCA	0.358		NaN											0	0	0	0.003163	0	14	43									
OSGEPL1	64172	broad.mit.edu	37	2	190619038	190619038	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:190619038C>T	uc002uqz.1	-	4	1177	c.643G>A	c.(643-645)GAG>AAG	p.E215K	OSGEPL1_uc002ura.1_RNA	NM_022353	NP_071748	Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	215					proteolysis|tRNA processing		metalloendopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			GTGGAGCACTCTGGATGTTTT	0.348		NaN											0	0	0	0.00308	0	8	27									
GLS	2744	broad.mit.edu	37	2	191792056	191792056	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:191792056G>A	uc002usf.2	+	12	1537	c.1273G>A	c.(1273-1275)GAA>AAA	p.E425K	GLS_uc002use.2_Missense_Mutation_p.E425K|GLS_uc002usg.1_Missense_Mutation_p.E86K|GLS_uc002ush.2_Missense_Mutation_p.E86K|GLS_uc010zgi.1_5'UTR|GLS_uc010zgj.1_5'Flank	NM_014905	NP_055720	O94925	GLSK_HUMAN	glutaminase precursor	425					cellular amino acid biosynthetic process|glutamate secretion|glutamine catabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity			ovary(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.00625)|Epithelial(96;0.0744)|all cancers(119;0.181)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AGTGACTTGTGAATCAGCCAG	0.383		NaN											0	0	0	0.00499	0	13	28									
PLCL1	5334	broad.mit.edu	37	2	198950660	198950660	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:198950660G>A	uc010fsp.2	+	2	2710	c.2419G>A	c.(2419-2421)GAG>AAG	p.E807K	PLCL1_uc002uuv.3_Missense_Mutation_p.E728K	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	807	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CATTGGGGATGAGTTTATAGG	0.423		NaN											0	0	0	0.003755	0	38	75									
SPATS2L	26010	broad.mit.edu	37	2	201342726	201342726	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:201342726C>G	uc002uvn.3	+	13	2001	c.1649C>G	c.(1648-1650)TCA>TGA	p.S550*	SPATS2L_uc010fst.2_Nonsense_Mutation_p.S550*|SPATS2L_uc002uvo.3_Nonsense_Mutation_p.S490*|SPATS2L_uc002uvp.3_Nonsense_Mutation_p.S550*|SPATS2L_uc002uvq.3_Nonsense_Mutation_p.S481*|SPATS2L_uc002uvr.3_Nonsense_Mutation_p.S550*|SPATS2L_uc010zhc.1_Nonsense_Mutation_p.S580*	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	550						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						GCAGTTCTCTCAGTCCCGGCT	0.562		NaN											0	0	0	0.008291	0	11	15									
ALS2CR4	65062	broad.mit.edu	37	2	202494121	202494121	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:202494121C>G	uc002uyh.1	-	10	802	c.701G>C	c.(700-702)GGA>GCA	p.G234A	ALS2CR4_uc002uyg.1_Missense_Mutation_p.G226A|ALS2CR4_uc010zho.1_Missense_Mutation_p.G29A|ALS2CR4_uc010zhp.1_RNA	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	258	Helical; (Potential).					integral to membrane	protein binding				0						AGCCAAGAATCCATGAGAAAA	0.358		NaN											0	0	0	0.001168	0	6	4									
NBEAL1	65065	broad.mit.edu	37	2	204055050	204055050	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:204055050G>C	uc002uzt.3	+	45	7105	c.6772G>C	c.(6772-6774)GAA>CAA	p.E2258Q	NBEAL1_uc002uzs.3_Missense_Mutation_p.E968Q	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2258	BEACH.						binding			ovary(1)|skin(1)	2						AGATGAGAAAGAAAGAAAAGC	0.353		NaN											0	0	0	0.003755	0	34	83									
PLEKHM3	389072	broad.mit.edu	37	2	208725884	208725884	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:208725884C>T	uc002vcl.2	-	7	2543	c.2053G>A	c.(2053-2055)GAA>AAA	p.E685K		NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	685	Phorbol-ester/DAG-type.				intracellular signal transduction		metal ion binding			ovary(1)	1						TTACAGATTTCACAGATGAAC	0.408		NaN											0	0	0	0.01441	0	88	41									
PIKFYVE	200576	broad.mit.edu	37	2	209190606	209190606	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:209190606G>A	uc002vcz.2	+	20	3229	c.3071G>A	c.(3070-3072)GGA>GAA	p.G1024E	PIKFYVE_uc010fun.1_Missense_Mutation_p.G705E|PIKFYVE_uc002vcy.1_Missense_Mutation_p.G968E	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1024					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						GATGACACTGGATTATATGTT	0.443		NaN											0	0	0	0.01441	0	50	15									
PIKFYVE	200576	broad.mit.edu	37	2	209190762	209190762	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:209190762C>G	uc002vcz.2	+	20	3385	c.3227C>G	c.(3226-3228)TCT>TGT	p.S1076C	PIKFYVE_uc010fun.1_Missense_Mutation_p.S757C|PIKFYVE_uc002vcy.1_Missense_Mutation_p.S1020C	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1076					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						ATGAGATGCTCTACCCGAGAT	0.423		NaN											0	0	0	0.00632	0	27	50									
SPAG16	79582	broad.mit.edu	37	2	214174842	214174842	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:214174842C>T	uc002veq.2	+	4	431	c.339C>T	c.(337-339)CTC>CTT	p.L113L	SPAG16_uc010fuz.1_Intron|SPAG16_uc002ver.2_Silent_p.L59L|SPAG16_uc010zjk.1_Intron|SPAG16_uc002veo.2_Silent_p.L113L|SPAG16_uc002vep.1_Intron|SPAG16_uc002ves.1_Silent_p.L82L	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	113					cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AAGACTTTCTCTGCAATTTCT	0.318		NaN											0	0	0	0.00632	0	27	57									
ABCA12	26154	broad.mit.edu	37	2	215813432	215813432	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:215813432G>A	uc002vew.2	-	47	7212	c.6992C>T	c.(6991-6993)TCA>TTA	p.S2331L	ABCA12_uc002vev.2_Missense_Mutation_p.S2013L|ABCA12_uc010zjn.1_Missense_Mutation_p.S1258L	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2331	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GCCAACTAATGAGCTGTGAGA	0.418		NaN											0	0	0	0.013726	0	32	63									
ABCA12	26154	broad.mit.edu	37	2	215852376	215852376	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:215852376G>A	uc002vew.2	-	27	4191	c.3971C>T	c.(3970-3972)TCT>TTT	p.S1324F	ABCA12_uc002vev.2_Missense_Mutation_p.S1006F|ABCA12_uc010zjn.1_Missense_Mutation_p.S251F	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1324					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTTACTGGCAGATGGGTTGGT	0.408		NaN											0	0	0	0.005443	0	22	38									
ATIC	471	broad.mit.edu	37	2	216200791	216200791	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:216200791G>A	uc002vex.3	+	11	1216	c.1042G>A	c.(1042-1044)GAA>AAA	p.E348K	ATIC_uc010zjo.1_Missense_Mutation_p.E289K|ATIC_uc002vey.3_Missense_Mutation_p.E347K	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	348					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	AGGATATGAAGAAGAAGCCTT	0.308		NaN	T	ALK	ALCL								0	0	0	0.01441	0	64	91									
TTLL4	9654	broad.mit.edu	37	2	219602555	219602555	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:219602555C>T	uc002viy.2	+	3	526	c.156C>T	c.(154-156)ATC>ATT	p.I52I	TTLL4_uc010zkl.1_Intron|TTLL4_uc010fvx.2_Silent_p.I52I	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	52					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TGAAGCCAATCTGGAAGCTGG	0.592		NaN											0	0	0	0.007291	0	30	99									
ATG9A	79065	broad.mit.edu	37	2	220085580	220085580	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:220085580G>A	uc002vke.1	-	15	2589	c.2403C>T	c.(2401-2403)TTC>TTT	p.F801F	ABCB6_uc002vkc.1_5'Flank|ABCB6_uc010fwe.1_5'Flank|ABCB6_uc010zku.1_5'Flank|ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Silent_p.F801F	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	801	Cytoplasmic (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAGCCGAGAGAAATGAGAGG	0.582		NaN											0	0	0	0.00499	0	15	49									
SPEG	10290	broad.mit.edu	37	2	220309694	220309694	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:220309694C>T	uc010fwg.2	+	3	626	c.626C>T	c.(625-627)CCG>CTG	p.P209L	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_5'UTR|SPEG_uc002vln.1_5'UTR	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	209					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CGCCGCCTCCCGGGCAGCCCA	0.716		NaN											0	0	0	0.001168	0	5	12									
SLC4A3	6508	broad.mit.edu	37	2	220494009	220494009	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:220494009G>A	uc002vmp.3	+	4	630	c.361G>A	c.(361-363)GAG>AAG	p.E121K	SLC4A3_uc002vmn.2_Missense_Mutation_p.E121K|SLC4A3_uc002vmo.3_Missense_Mutation_p.E121K|SLC4A3_uc010fwm.2_5'UTR|SLC4A3_uc010fwn.1_5'Flank	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	121	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCTCCCTCCGAGGGGACCCC	0.547		NaN											0	0	0	0.013537	0	13	18									
PAX3	5077	broad.mit.edu	37	2	223096999	223096999	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:223096999G>A	uc010fwo.2	-	5	956	c.590C>T	c.(589-591)TCA>TTA	p.S197L	PAX3_uc002vmt.1_Missense_Mutation_p.S197L|PAX3_uc002vmy.1_Missense_Mutation_p.S196L|PAX3_uc002vmv.1_Missense_Mutation_p.S197L|PAX3_uc002vmw.1_Missense_Mutation_p.S197L|PAX3_uc002vmx.1_Missense_Mutation_p.S197L	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	197					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTGGGGTGCTGAGGCTAAAAG	0.328		NaN	T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						0	0	0	0.007413	0	20	118									
IRS1	3667	broad.mit.edu	37	2	227662785	227662785	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:227662785C>T	uc002voh.3	-	1	722	c.670G>A	c.(670-672)GAG>AAG	p.E224K		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	224	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CGGCCCACCTCGATGAAGAAG	0.607		NaN									OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007413	0	19	27									
UGT1A1	54658	broad.mit.edu	37	2	234669682	234669682	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:234669682C>G	uc002vvb.2	+	1	764	c.749C>G	c.(748-750)TCT>TGT	p.S250C	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron|UGT1A9_uc002vva.2_Intron|UGT1A1_uc010znc.1_Missense_Mutation_p.S250C	NM_000463	NP_000454	P22309	UD11_HUMAN	UDP glycosyltransferase 1 family, polypeptide A1	250					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			central_nervous_system(1)|skin(1)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CTATTGAGCTCTGCATCTGTC	0.468		NaN											0	0	0	0.009535	0	29	66									
ANO7	50636	broad.mit.edu	37	2	242135138	242135138	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:242135138G>T	uc002wax.2	+	4	452	c.349G>T	c.(349-351)GAG>TAG	p.E117*	ANO7_uc002waw.2_Nonsense_Mutation_p.E116*	NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	117	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CCTCGTTTGGGAGGAGGACCT	0.617		NaN											1	0	4.36969e-10	0.001855	4.54565e-10	12	8									
ANO7	50636	broad.mit.edu	37	2	242162689	242162689	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:242162689G>A	uc002wax.2	+	22	2675	c.2572G>A	c.(2572-2574)GAG>AAG	p.E858K		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	858	Helical; (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CATTGTGTTTGAGGTAGCCGA	0.577		NaN											0	0	0	0.01441	0	47	14									
ANO7	50636	broad.mit.edu	37	2	242163167	242163167	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:242163167C>T	uc002wax.2	+	23	2768	c.2665C>T	c.(2665-2667)CTG>TTG	p.L889L		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	889	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						GGAGTACTACCTGGCTAAGCA	0.592		NaN											0	0	0	0.001855	0	13	21									
RSPO4	343637	broad.mit.edu	37	20	947851	947851	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:947851G>A	uc002wej.2	-	3	472	c.375C>T	c.(373-375)GGC>GGT	p.G125G	RSPO4_uc002wek.2_Silent_p.G125G	NM_001029871	NP_001025042	Q2I0M5	RSPO4_HUMAN	R-spondin family, member 4 isoform 1 precursor	125	FU.				Wnt receptor signaling pathway	extracellular region	heparin binding				0						GGGCCAAAGTGCCCGGCGGGC	0.652		NaN											0	0	0	0.008291	0	9	27									
SIRPG	55423	broad.mit.edu	37	20	1629746	1629746	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:1629746C>T	uc002wfm.1	-	2	447	c.382G>A	c.(382-384)GAG>AAG	p.E128K	SIRPG_uc002wfn.1_Missense_Mutation_p.E128K|SIRPG_uc002wfo.1_Missense_Mutation_p.E128K	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	128	Extracellular (Potential).|Ig-like V-type.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						TCCACGTTCTCAGGGCTCCCT	0.488		NaN											0	0	0	0.01441	0	47	164									
TGM6	343641	broad.mit.edu	37	20	2413155	2413155	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:2413155C>T	uc002wfy.1	+	13	2048	c.1987C>T	c.(1987-1989)CAG>TAG	p.Q663*	TGM6_uc010gal.1_Missense_Mutation_p.S618L	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	663					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CCTGGAGCCTCAGGAGAGGGC	0.607		NaN											0	0	0	0.008871	0	18	55									
PTPRA	5786	broad.mit.edu	37	20	2945569	2945569	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:2945569G>C	uc010zqb.1	+	5	529	c.136G>C	c.(136-138)GAG>CAG	p.E46Q	PTPRA_uc002whj.2_Missense_Mutation_p.E46Q|PTPRA_uc010zqc.1_Intron|PTPRA_uc002whk.2_Missense_Mutation_p.E46Q|PTPRA_uc010zqd.1_Missense_Mutation_p.E57Q|PTPRA_uc002whl.2_Missense_Mutation_p.E46Q|PTPRA_uc002whm.2_5'UTR|PTPRA_uc002whn.2_Missense_Mutation_p.E46Q			P18433	PTPRA_HUMAN	SubName: Full=cDNA FLJ60525, highly similar to Receptor-type tyrosine-protein phosphatase alpha (EC 3.1.3.48);	46	Extracellular (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1						AGTTAAAGAAGAGGCCAAAAC	0.388		NaN											0	0	0	0.009535	0	31	71									
PTPRA	5786	broad.mit.edu	37	20	2968991	2968991	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:2968991G>A	uc010zqd.1	+	8	959	c.642G>A	c.(640-642)CAG>CAA	p.Q214Q	PTPRA_uc002whj.2_Silent_p.Q203Q|PTPRA_uc010zqc.1_Silent_p.Q88Q|PTPRA_uc002whk.2_Silent_p.Q194Q|PTPRA_uc002whl.2_Silent_p.Q194Q|PTPRA_uc002whm.2_5'UTR|PTPRA_uc002whn.2_Silent_p.Q194Q|PTPRA_uc002who.2_5'UTR	NM_002836	NP_002827	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	203	Cytoplasmic (Potential).				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.T214I(1)		upper_aerodigestive_tract(1)	1						CAGAGCCCCAGAGTGTGCCAC	0.567		NaN											0	0	0	0.00333	0	22	82									
ADAM33	80332	broad.mit.edu	37	20	3655675	3655675	+	Missense_Mutation	SNP	G	G	A	rs146682885		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:3655675G>A	uc002wit.2	-	4	419	c.332C>T	c.(331-333)ACG>ATG	p.T111M	ADAM33_uc002wir.1_Missense_Mutation_p.T111M|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.T111M|ADAM33_uc002wiw.1_RNA|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Missense_Mutation_p.T110M|ADAM33_uc010zqg.1_Missense_Mutation_p.T110M|ADAM33_uc010zqh.1_Missense_Mutation_p.T111M	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	111	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						GCATCTCACCGTGTGGTTGGG	0.622		NaN											0	0	0	0.008291	0	10	17									
PANK2	80025	broad.mit.edu	37	20	3891268	3891268	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:3891268G>A	uc002wkc.2	+	3	1032	c.1026G>A	c.(1024-1026)TTG>TTA	p.L342L	PANK2_uc002wkb.2_Silent_p.L51L|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_Silent_p.L51L|PANK2_uc002wkf.2_5'UTR	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	342					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						TAGATTGCTTGATCAAAGGAA	0.353		NaN											0	0	0	0.01441	0	71	116									
ADRA1D	146	broad.mit.edu	37	20	4202235	4202235	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:4202235C>T	uc002wkr.2	-	2	1709	c.1654G>A	c.(1654-1656)GAG>AAG	p.E552K		NM_000678	NP_000669	P25100	ADA1D_HUMAN	alpha-1D-adrenergic receptor	552	Cytoplasmic (By similarity).			KPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRA EAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRET DI -> SHPAPSASGGCWGRSGDPRPSCAPKSPACRTRSPP GARSAQRQRAPSAQRWRLCP (in Ref. 1).	cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity				0					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	GTGGCGCCCTCGGCCACCTCG	0.682		NaN											0	0	0	0.001984	0	7	34									
GPCPD1	56261	broad.mit.edu	37	20	5556510	5556510	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:5556510G>C	uc002wme.3	-	9	1033	c.820C>G	c.(820-822)CTT>GTT	p.L274V	GPCPD1_uc002wmd.3_Missense_Mutation_p.L93V	NM_019593	NP_062539	Q9NPB8	GPCP1_HUMAN	hypothetical protein LOC56261	274					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0						ATGATGGGAAGAGTAAGAATT	0.438		NaN											0	0	0	0.008361	0	31	130									
MCM8	84515	broad.mit.edu	37	20	5935298	5935298	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:5935298G>C	uc002wmi.2	+	4	675	c.298G>C	c.(298-300)GAA>CAA	p.E100Q	MCM8_uc002wmj.2_Missense_Mutation_p.E100Q|MCM8_uc002wmk.2_Missense_Mutation_p.E100Q|MCM8_uc002wml.2_Missense_Mutation_p.E100Q|MCM8_uc010gbp.2_Missense_Mutation_p.E100Q	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	100					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						TCAAGCATTTGAAAAATTTTT	0.363		NaN											0	0	0	0.00499	0	17	73									
JAG1	182	broad.mit.edu	37	20	10625512	10625512	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:10625512C>T	uc002wnw.2	-	18	2859	c.2343G>A	c.(2341-2343)CAG>CAA	p.Q781Q	JAG1_uc010gcd.1_Silent_p.Q339Q	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	781	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GACACTCACTCTGAGCACAGA	0.592		NaN							Alagille_Syndrome				0	0	0	0.01441	0	50	96									
TASP1	55617	broad.mit.edu	37	20	13550189	13550189	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:13550189C>T	uc002woi.2	-	7	650	c.533G>A	c.(532-534)GGA>GAA	p.G178E	TASP1_uc010zri.1_Intron|TASP1_uc002woh.2_Missense_Mutation_p.G155E|TASP1_uc010zrj.1_Intron	NM_017714	NP_060184	Q9H6P5	TASP1_HUMAN	taspase 1 precursor	178					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity				0						AGAGGGTATTCCATGATCTAC	0.333		NaN											0	0	0	0.005443	0	21	98									
KIF16B	55614	broad.mit.edu	37	20	16362382	16362382	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:16362382C>T	uc002wpg.1	-	18	1953	c.1795G>A	c.(1795-1797)GAG>AAG	p.E599K	KIF16B_uc002wpe.1_5'Flank|KIF16B_uc002wpf.1_5'Flank|KIF16B_uc010gch.1_Missense_Mutation_p.E599K|KIF16B_uc010gci.1_Missense_Mutation_p.E599K|KIF16B_uc010gcj.1_Missense_Mutation_p.E610K	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	599	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TGTTGCCTCTCAAATTCAAGT	0.343		NaN											0	0	0	0.008291	0	10	43									
BFSP1	631	broad.mit.edu	37	20	17479526	17479526	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:17479526G>A	uc002wpo.2	-	6	934	c.895C>T	c.(895-897)CAG>TAG	p.Q299*	BFSP1_uc002wpp.2_Nonsense_Mutation_p.Q174*|BFSP1_uc010zrn.1_Nonsense_Mutation_p.Q160*|BFSP1_uc010zro.1_Nonsense_Mutation_p.Q160*	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	299	Rod.|Coil 2.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						AGGGTTTGCTGGGCGACCGCC	0.532		NaN											0	0	0	0.007413	0	19	24									
C20orf72	92667	broad.mit.edu	37	20	17950541	17950541	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:17950541C>G	uc002wqh.2	+	2	121	c.39C>G	c.(37-39)CTC>CTG	p.L13L	C20orf72_uc010gco.2_RNA|C20orf72_uc010gcp.2_5'Flank|SNX5_uc002wqc.2_5'Flank|SNX5_uc002wqd.2_5'Flank|SNX5_uc002wqe.2_5'Flank|SNX5_uc010zrt.1_5'Flank|SNX5_uc010gcn.1_5'Flank	NM_052865	NP_443097	Q9BQP7	CT072_HUMAN	hypothetical protein LOC92667	13											0						GCAGGCAGCTCAGGAGTTCAA	0.408		NaN											0	0	0	0.012319	0	20	83									
CSRP2BP	57325	broad.mit.edu	37	20	18162455	18162455	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:18162455C>T	uc002wqj.2	+	8	2395	c.1773C>T	c.(1771-1773)AGC>AGT	p.S591S	CSRP2BP_uc002wqk.2_Silent_p.S463S|CSRP2BP_uc010zru.1_Silent_p.S462S	NM_020536	NP_065397	Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	591					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			lung(3)|ovary(2)|skin(1)	6						GTATTGTCAGCCCTTATACCT	0.458		NaN											0	0	0	0.007413	0	20	114									
SLC24A3	57419	broad.mit.edu	37	20	19565642	19565642	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:19565642G>A	uc002wrl.2	+	5	648	c.451G>A	c.(451-453)GGG>AGG	p.G151R		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	151	Cytoplasmic (Potential).|Alpha-1.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						AGATGTGGCTGGGGCCACATT	0.552		NaN											0	0	0	0.00333	0	16	54									
PAX1	5075	broad.mit.edu	37	20	21687492	21687492	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:21687492G>A	uc002wsj.2	+	2	757	c.703G>A	c.(703-705)GAG>AAG	p.E235K	PAX1_uc010zsl.1_Missense_Mutation_p.E235K|PAX1_uc010zsm.1_Missense_Mutation_p.E211K	NM_006192	NP_006183	P15863	PAX1_HUMAN	paired box 1	235					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			upper_aerodigestive_tract(1)|kidney(1)	2						CGGACCGTACGAGGCAAGTAA	0.647		NaN											0	0	0	0.008291	0	5	9									
CST9L	128821	broad.mit.edu	37	20	23549008	23549008	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:23549008T>C	uc002wtk.3	-	1	379	c.80A>G	c.(79-81)TAT>TGT	p.Y27C		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	27						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					ATGCCAGGCATAGATCAGCAG	0.567		NaN											0	0	0	0.00499	0	18	33									
CST1	1469	broad.mit.edu	37	20	23728490	23728490	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:23728490C>G	uc002wtp.2	-	3	460	c.389G>C	c.(388-390)AGA>ACA	p.R130T		NM_001898	NP_001889	P01037	CYTN_HUMAN	cystatin SN precursor	130						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Lung NSC(19;0.0676)|all_lung(19;0.148)					CAGGGACCTTCTGTTCTCCCA	0.542		NaN											0	0	0	0.001855	0	13	41									
ACSS1	84532	broad.mit.edu	37	20	24994205	24994205	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:24994205G>A	uc002wub.2	-	10	2424	c.1546C>T	c.(1546-1548)CGA>TGA	p.R516*	ACSS1_uc002wuc.2_Nonsense_Mutation_p.R514*|ACSS1_uc010gdc.2_Nonsense_Mutation_p.R311*|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Nonsense_Mutation_p.R433*	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	516					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TCCACAAATCGCTGGTGGTCG	0.592		NaN											0	0	0	0.000602	0	5	15									
DEFB123	245936	broad.mit.edu	37	20	30037947	30037947	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30037947C>A	uc002wvy.2	+	2	265	c.174C>A	c.(172-174)TAC>TAA	p.Y58*		NM_153324	NP_697019	Q8N688	DB123_HUMAN	defensin, beta 123 precursor	58					defense response to bacterium	extracellular region					0	Lung NSC(7;0.000139)|all_lung(7;0.000197)|all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			AGCCCAAGTACCAGCCAAAAG	0.423		NaN											1	0	5.01169e-05	0.00499	5.11301e-05	15	77									
BCL2L1	598	broad.mit.edu	37	20	30309932	30309932	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30309932C>T	uc002wwl.2	-	2	456	c.90G>A	c.(88-90)GTG>GTA	p.V30V	BCL2L1_uc002wwk.2_RNA|BCL2L1_uc002wwm.2_Silent_p.V30V|BCL2L1_uc002wwn.2_Silent_p.V30V|BCL2L1_uc002wwo.1_Silent_p.V30V	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	BCL2-like 1 isoform 1	30					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			lung(1)|central_nervous_system(1)	2	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			TGTTCTCTTCCACATCACTAA	0.527		NaN											0	0	0	0.01441	0	61	77									
FOXS1	2307	broad.mit.edu	37	20	30432733	30432733	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30432733C>T	uc002wwt.1	-	1	688	c.613G>A	c.(613-615)GAG>AAG	p.E205K		NM_004118	NP_004109	O43638	FOXS1_HUMAN	forkhead box S1	205					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(1)	1						ACGGGGAGCTCCCCTGGGCAT	0.612		NaN											0	0	0	0.009096	0	4	36									
XKR7	343702	broad.mit.edu	37	20	30556321	30556321	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30556321G>A	uc002wxe.2	+	1	517	c.343G>A	c.(343-345)GAC>AAC	p.D115N		NM_001011718	NP_001011718	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related	115						integral to membrane				ovary(1)|breast(1)|skin(1)	3			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GTTCGTCTACGACTACTCGGA	0.642		NaN											0	0	0	0.00308	0	8	10									
TM9SF4	9777	broad.mit.edu	37	20	30745699	30745699	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:30745699G>A	uc002wxj.2	+	14	1667	c.1432G>A	c.(1432-1434)GAC>AAC	p.D478N	TM9SF4_uc010zts.1_Missense_Mutation_p.D385N|TM9SF4_uc002wxk.2_Missense_Mutation_p.D461N|TM9SF4_uc010gdz.2_Missense_Mutation_p.D357N	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	478						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCAGCCATATGACAACCCTGT	0.592		NaN											0	0	0	0.01441	0	41	57									
CDK5RAP1	51654	broad.mit.edu	37	20	31946862	31946862	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:31946862G>C	uc010gek.2	-	15	1917	c.1793C>G	c.(1792-1794)TCT>TGT	p.S598C	CDK5RAP1_uc002wyy.2_Missense_Mutation_p.S494C|CDK5RAP1_uc002wyz.2_Missense_Mutation_p.S584C|CDK5RAP1_uc002wza.2_Missense_Mutation_p.S583C|CDK5RAP1_uc010gel.2_Missense_Mutation_p.S493C|CDK5RAP1_uc010gem.2_Missense_Mutation_p.S507C|CDK5RAP1_uc002wzc.1_3'UTR|CDK5RAP1_uc002wzb.1_3'UTR	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	598					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						GCAATATGCAGAAGAGTCCCT	0.517		NaN											0	0	0	0.00245	0	15	85									
SNTA1	6640	broad.mit.edu	37	20	32005554	32005554	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:32005554C>T	uc002wzd.1	-	3	944	c.672G>A	c.(670-672)AAG>AAA	p.K224K	SNTA1_uc010zuf.1_Silent_p.K224K	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	224	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						GGGTGCACCTCTTCGAGACAT	0.607		NaN											0	0	0	0.00333	0	22	47									
C20orf144	128864	broad.mit.edu	37	20	32251342	32251342	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:32251342G>A	uc002wzs.1	+	2	163	c.131G>A	c.(130-132)AGG>AAG	p.R44K	NECAB3_uc002wzl.2_5'Flank|NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron|C20orf134_uc002wzt.2_5'Flank	NM_080825	NP_543015	Q9BQM9	CT144_HUMAN	hypothetical protein LOC128864	44											0						CCCCAGACCAGGATCGTGCTG	0.726		NaN											0	0	0	0.009096	0	3	17									
ITCH	83737	broad.mit.edu	37	20	33077105	33077105	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33077105G>A	uc010geu.1	+	22	2443	c.2251G>A	c.(2251-2253)GAA>AAA	p.E751K	ITCH_uc002xak.2_Missense_Mutation_p.E710K|ITCH_uc010zuj.1_Missense_Mutation_p.E600K	NM_031483	NP_113671	Q96J02	ITCH_HUMAN	itchy homolog E3 ubiquitin protein ligase	751	HECT.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			breast(4)|lung(1)|central_nervous_system(1)	6						TCGAGGTGTTGAAGAACAGAC	0.348		NaN											0	0	0	0.009535	0	29	92									
DYNLRB1	83658	broad.mit.edu	37	20	33114076	33114076	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33114076G>A	uc002xal.2	+	2	67	c.7G>A	c.(7-9)GAG>AAG	p.E3K	DYNLRB1_uc010zuk.1_Missense_Mutation_p.E3K|DYNLRB1_uc002xam.2_RNA|DYNLRB1_uc002xan.2_Splice_Site|DYNLRB1_uc002xao.2_RNA	NM_014183	NP_054902	Q9NP97	DLRB1_HUMAN	Roadblock-1	3					microtubule-based movement|transport|visual behavior	centrosome|cytoplasmic dynein complex|microtubule	microtubule motor activity				0						CTGGCAGGCAGAGGTGGAGGA	0.547		NaN											0	0	0	0.001168	0	5	33									
NCOA6	23054	broad.mit.edu	37	20	33346669	33346669	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33346669C>T	uc002xav.2	-	7	3153	c.582G>A	c.(580-582)ATG>ATA	p.M194I	NCOA6_uc002xaw.2_Missense_Mutation_p.M194I|NCOA6_uc010gew.1_Intron	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	194	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						CTGGTGCCATCATGGAAGATG	0.478		NaN											0	0	0	0.010504	0	20	90									
GSS	2937	broad.mit.edu	37	20	33533875	33533875	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33533875G>A	uc002xbg.2	-	3	236	c.156C>T	c.(154-156)CTC>CTT	p.L52L	GSS_uc010zun.1_5'UTR|GSS_uc010zuo.1_Silent_p.L52L|GSS_uc010zup.1_Intron|GSS_uc002xbh.2_RNA|GSS_uc010gez.1_5'UTR	NM_000178	NP_000169	P48637	GSHB_HUMAN	glutathione synthetase	52					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GTGAGGGGAAGAGCGTGAATG	0.567		NaN											0	0	0	0.005443	0	25	133									
TRPC4AP	26133	broad.mit.edu	37	20	33591402	33591402	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33591402G>C	uc002xbk.2	-	18	2101	c.2067C>G	c.(2065-2067)CTC>CTG	p.L689L	TRPC4AP_uc002xbj.2_RNA|TRPC4AP_uc010zuq.1_Silent_p.L280L|TRPC4AP_uc002xbl.2_Silent_p.L681L|TRPC4AP_uc010zur.1_Silent_p.L650L	NM_015638	NP_056453	Q8TEL6	TP4AP_HUMAN	TRPC4-associated protein isoform a	689					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GGCTGGTGTTGAGGCAGCTGA	0.662		NaN											0	0	0	0.001168	0	5	24									
EIF6	3692	broad.mit.edu	37	20	33872046	33872046	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33872046G>A	uc002xbv.1	-	2	342	c.126C>T	c.(124-126)CTC>CTT	p.L42L	EIF6_uc002xbx.1_Silent_p.L42L|EIF6_uc002xbz.1_Missense_Mutation_p.S82F|EIF6_uc002xby.1_RNA	NM_181468	NP_852133	P56537	IF6_HUMAN	eukaryotic translation initiation factor 6	42					mature ribosome assembly	cytoplasm|nucleolus	protein binding|ribosome binding|translation initiation factor activity			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TGGTATCGGAGAGCTCGCCCT	0.677		NaN											0	0	0	0.003163	0	14	56									
FAM83C	128876	broad.mit.edu	37	20	33879833	33879833	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:33879833C>T	uc010zux.1	-	1	393	c.275G>A	c.(274-276)AGC>AAC	p.S92N	FAM83C_uc002xcb.1_5'UTR	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	92										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CTGAGCCTCGCTGAGCTCAGG	0.662		NaN											0	0	0	0.006214	0	8	45									
CEP250	11190	broad.mit.edu	37	20	34057761	34057761	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:34057761G>A	uc002xcm.2	+	11	1569	c.898G>A	c.(898-900)GAA>AAA	p.E300K	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_RNA|CEP250_uc002xco.2_Missense_Mutation_p.E107K	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	300	Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GAAGCAAAATGAAGATTATGA	0.488		NaN											0	0	0	0.004878	0	34	57									
RBL1	5933	broad.mit.edu	37	20	35627227	35627227	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:35627227G>A	uc002xgi.2	-	22	3221	c.3142C>T	c.(3142-3144)CAA>TAA	p.Q1048*	RBL1_uc010zvt.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	1048					cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				TCATTTTCTTGACAGACGCGT	0.398		NaN											0	0	0	0.01441	0	59	85									
FAM83D	81610	broad.mit.edu	37	20	37576568	37576568	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:37576568G>A	uc002xjg.2	+	3	832	c.791G>A	c.(790-792)GGA>GAA	p.G264E		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	234					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				GCAAGGTCAGGAACTAAGATT	0.438		NaN											0	0	0	0.003755	0	34	125									
FAM83D	81610	broad.mit.edu	37	20	37576605	37576605	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:37576605G>A	uc002xjg.2	+	3	869	c.828G>A	c.(826-828)ACG>ACA	p.T276T		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	246					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				AAAAGTTCACGTTGATTGATG	0.438		NaN											0	0	0	0.006122	0	19	108									
EMILIN3	90187	broad.mit.edu	37	20	39990348	39990348	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:39990348C>T	uc002xjy.1	-	4	2085	c.1861G>A	c.(1861-1863)GAG>AAG	p.E621K		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	621	Potential.					proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CGTTCCCGCTCATCCAGGGAC	0.592		NaN											0	0	0	0.008361	0	29	35									
TOMM34	10953	broad.mit.edu	37	20	43571786	43571786	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:43571786C>T	uc002xmy.2	-	7	1034	c.894G>A	c.(892-894)CAG>CAA	p.Q298Q	PABPC1L_uc002xmx.2_Intron|TOMM34_uc002xmz.2_RNA	NM_006809	NP_006800	Q15785	TOM34_HUMAN	translocase of outer mitochondrial membrane 34	298					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	heat shock protein binding|signal sequence binding				0		Myeloproliferative disorder(115;0.0122)				GCCGCAACTTCTGTGCAGGAC	0.507		NaN											0	0	0	0.003163	0	12	70									
STK4	6789	broad.mit.edu	37	20	43623860	43623860	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:43623860G>A	uc002xnb.2	+	6	745	c.655G>A	c.(655-657)GAA>AAA	p.E219K	STK4_uc010ggx.2_Missense_Mutation_p.E219K|STK4_uc010ggy.2_Missense_Mutation_p.E164K|STK4_uc010ggw.1_Missense_Mutation_p.E219K	NM_006282	NP_006273	Q13043	STK4_HUMAN	serine/threonine kinase 4	219	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				AGAAATGGCTGAAGGAAAGCC	0.443		NaN											0	0	0	0.008871	0	20	73									
WFDC13	164237	broad.mit.edu	37	20	44330765	44330765	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:44330765G>A	uc002xpd.2	+	1	111	c.3G>A	c.(1-3)ATG>ATA	p.M1I	WFDC10B_uc002xpb.2_Intron|WFDC10B_uc002xpc.2_Intron	NM_172005	NP_742002	Q8IUB5	WFD13_HUMAN	WAP four-disulfide core domain 13 precursor	1						extracellular region	peptidase inhibitor activity				0		Myeloproliferative disorder(115;0.0122)				CTGACACCATGAAGCCTGTGC	0.567		NaN											0	0	0	0.001168	0	6	15									
ZMYND8	23613	broad.mit.edu	37	20	45976605	45976605	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:45976605G>A	uc002xta.1	-	2	274	c.20C>T	c.(19-21)TCC>TTC	p.S7F	ZMYND8_uc010ghr.1_Missense_Mutation_p.S7F|ZMYND8_uc002xst.1_Missense_Mutation_p.S7F|ZMYND8_uc002xsu.1_Missense_Mutation_p.S7F|ZMYND8_uc002xsv.1_Missense_Mutation_p.S7F|ZMYND8_uc002xsw.1_5'UTR|ZMYND8_uc002xsx.1_5'UTR|ZMYND8_uc002xsy.1_Missense_Mutation_p.S7F|ZMYND8_uc002xsz.1_Missense_Mutation_p.S7F|ZMYND8_uc010zxy.1_Missense_Mutation_p.S34F|ZMYND8_uc002xtb.1_Missense_Mutation_p.S27F|ZMYND8_uc002xss.2_Missense_Mutation_p.S32F|ZMYND8_uc010zxz.1_Missense_Mutation_p.S27F|ZMYND8_uc002xtc.1_Missense_Mutation_p.S27F|ZMYND8_uc002xtd.1_Missense_Mutation_p.S27F|ZMYND8_uc002xte.1_Missense_Mutation_p.S7F|ZMYND8_uc010zya.1_Missense_Mutation_p.S7F|ZMYND8_uc002xtf.1_Missense_Mutation_p.S27F|ZMYND8_uc010ghs.1_Missense_Mutation_p.S26F|ZMYND8_uc002xth.2_Missense_Mutation_p.S27F	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	7							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			CTCACCTTTGGAGCGAGTAGA	0.393		NaN											0	0	0	0.01441	0	56	97									
CSE1L	1434	broad.mit.edu	37	20	47675013	47675013	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:47675013G>A	uc002xty.2	+	2	147	c.13G>A	c.(13-15)GAT>AAT	p.D5N	CSE1L_uc010zyg.1_5'UTR|CSE1L_uc010ghx.2_Missense_Mutation_p.D5N	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	5					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			GGAACTCAGCGATGCAAATCT	0.333		NaN											0	0	0	0.008871	0	19	101									
SLC9A8	23315	broad.mit.edu	37	20	48466215	48466215	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:48466215C>T	uc002xuv.1	+	6	742	c.532C>T	c.(532-534)CAG>TAG	p.Q178*	SLC9A8_uc010zym.1_5'UTR|SLC9A8_uc010zyj.1_Nonsense_Mutation_p.Q178*|SLC9A8_uc010zyk.1_Nonsense_Mutation_p.Q178*|SLC9A8_uc010zyl.1_Nonsense_Mutation_p.Q150*|SLC9A8_uc010gib.1_Intron	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	178						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TTTTCTGGGTCAGGTAAGAAA	0.443		NaN											0	0	0	0.007291	0	29	54									
CEBPB	1051	broad.mit.edu	37	20	48808497	48808497	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:48808497G>A	uc002xvi.1	+	1	1122	c.927G>A	c.(925-927)GAG>GAA	p.E309E	CEBPB_uc002xvh.2_RNA	NM_005194	NP_005185	P17676	CEBPB_HUMAN	CCAAT/enhancer binding protein beta	309	Leucine-zipper.				acute-phase response|immune response		sequence-specific enhancer binding RNA polymerase II transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(9;5.72e-08)|STAD - Stomach adenocarcinoma(23;0.19)			TCACGGCCGAGAACGAGCGGC	0.662		NaN											0	0	0	0.001984	0	5	7									
FAM65C	140876	broad.mit.edu	37	20	49212713	49212713	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:49212713C>T	uc002xvm.2	-	15	2184	c.1866G>A	c.(1864-1866)CTG>CTA	p.L622L	FAM65C_uc010zyt.1_Silent_p.L626L|FAM65C_uc010zyu.1_RNA	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	622										ovary(2)	2						GGTGTACCATCAGCAGCACGT	0.597		NaN											0	0	0	0.007835	0	41	52									
SALL4	57167	broad.mit.edu	37	20	50401020	50401020	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:50401020C>T	uc002xwh.3	-	4	3047	c.2946G>A	c.(2944-2946)GTG>GTA	p.V982V	SALL4_uc010gii.2_Silent_p.V545V|SALL4_uc002xwi.3_Silent_p.V205V	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	982					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CATTGGTCTTCACGGCCAGAC	0.547		NaN											0	0	0	0.007835	0	39	71									
CYP24A1	1591	broad.mit.edu	37	20	52788164	52788164	+	Silent	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:52788164T>C	uc002xwv.2	-	3	893	c.495A>G	c.(493-495)AAA>AAG	p.K165K	CYP24A1_uc002xwu.1_Silent_p.K23K|CYP24A1_uc002xww.2_Silent_p.K165K	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	165					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GTTTCATTAGTTTCTTTTGAA	0.498		NaN											0	0	0	0.006999	0	40	170									
SPO11	23626	broad.mit.edu	37	20	55918412	55918412	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:55918412G>A	uc002xye.2	+	13	1180	c.1087G>A	c.(1087-1089)GAC>AAC	p.D363N	SPO11_uc002xyf.2_Missense_Mutation_p.D325N	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	363					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			AATAATGGCAGACTCTAAAAT	0.323		NaN						Editing_and_processing_nucleases					0	0	0	0.01441	0	48	91									
VAPB	9217	broad.mit.edu	37	20	56993382	56993382	+	Silent	SNP	C	C	T	rs139149560	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:56993382C>T	uc002xza.2	+	2	445	c.174C>T	c.(172-174)AGC>AGT	p.S58S	VAPB_uc002xzb.2_RNA|VAPB_uc010zzo.1_5'UTR|VAPB_uc002xzc.2_Silent_p.S58S	NM_004738	NP_004729	O95292	VAPB_HUMAN	VAMP-associated protein B/C	58	Cytoplasmic (Potential).|MSP.				cell death|endoplasmic reticulum unfolded protein response|positive regulation of viral genome replication|sphingolipid metabolic process|virus-host interaction	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	beta-tubulin binding|enzyme binding|protein heterodimerization activity|protein homodimerization activity|structural molecule activity			kidney(1)	1	Lung NSC(12;0.000615)|all_lung(29;0.00186)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;3.7e-08)|all cancers(14;3.88e-07)			GGCCCAACAGCGGAATCATCG	0.517		NaN											0	0	0	0.008871	0	20	112									
CDH4	1002	broad.mit.edu	37	20	60448896	60448896	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:60448896G>T	uc002ybn.1	+	7	1004	c.990G>T	c.(988-990)ATG>ATT	p.M330I	CDH4_uc002ybp.1_Missense_Mutation_p.M256I	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	330	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CCCAGAATATGTTCACCATCA	0.642		NaN											1	0	1.64293e-13	0.00333	1.72147e-13	22	85									
LAMA5	3911	broad.mit.edu	37	20	60893546	60893546	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:60893546G>A	uc002ycq.2	-	53	7270	c.7203C>T	c.(7201-7203)CTC>CTT	p.L2401L		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2401	Domain II and I.|Potential.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCGGCTGTTGAGCTCCTGGG	0.672		NaN											0	0	0	0.004007	0	11	11									
LAMA5	3911	broad.mit.edu	37	20	60908290	60908290	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:60908290G>A	uc002ycq.2	-	26	3205	c.3138C>T	c.(3136-3138)CTC>CTT	p.L1046L		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1046	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTGTGTGTAGAGGAGGCAGC	0.716		NaN											0	0	0	0.00308	0	8	18									
LAMA5	3911	broad.mit.edu	37	20	60910092	60910092	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:60910092A>G	uc002ycq.2	-	20	2534	c.2467T>C	c.(2467-2469)TAT>CAT	p.Y823H		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	823	Laminin EGF-like 10.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGCCAAAATAGTCAGCCTGA	0.652		NaN											0	0	0	0.001984	0	6	17									
ARFRP1	10139	broad.mit.edu	37	20	62338434	62338434	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:62338434G>C	uc002yga.2	-	1	577	c.10C>G	c.(10-12)CTG>GTG	p.L4V	ARFRP1_uc002ygc.2_Missense_Mutation_p.L4V|ARFRP1_uc002ygh.3_Missense_Mutation_p.L4V|ARFRP1_uc011abf.1_Missense_Mutation_p.L4V|ARFRP1_uc011abg.1_Missense_Mutation_p.L4V|ARFRP1_uc002yge.2_RNA|ARFRP1_uc002ygd.2_RNA|ARFRP1_uc002ygf.2_Missense_Mutation_p.L4V|ARFRP1_uc002ygg.2_RNA|ARFRP1_uc011abh.1_RNA|ZGPAT_uc002ygi.2_5'Flank|ZGPAT_uc002ygj.2_5'Flank|ZGPAT_uc002ygk.2_5'Flank|ZGPAT_uc010gkk.1_5'Flank|ZGPAT_uc010gkl.1_5'Flank|ZGPAT_uc002ygm.2_5'Flank|ZGPAT_uc002ygn.3_5'Flank	NM_003224	NP_003215	Q13795	ARFRP_HUMAN	ADP-ribosylation factor related protein 1	4					small GTPase mediated signal transduction	Golgi apparatus|membrane fraction	GTP binding|GTPase activity			breast(1)|skin(1)	2	all_cancers(38;9.53e-13)|all_epithelial(29;2.64e-14)|Lung NSC(23;7e-10)|all_lung(23;2.53e-09)		Epithelial(9;4.09e-08)|all cancers(9;1.7e-07)|OV - Ovarian serous cystadenocarcinoma(5;0.0102)			CCCGACAGCAGCGTGTACATC	0.443		NaN											0	0	0	0.001984	0	5	7									
ZGPAT	84619	broad.mit.edu	37	20	62340319	62340319	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:62340319G>A	uc002ygk.2	+	2	565	c.387G>A	c.(385-387)CTG>CTA	p.L129L	ARFRP1_uc002yga.2_5'Flank|ARFRP1_uc002ygc.2_5'Flank|ARFRP1_uc002ygh.3_5'Flank|ARFRP1_uc011abf.1_5'Flank|ARFRP1_uc011abg.1_5'Flank|ARFRP1_uc002yge.2_5'Flank|ARFRP1_uc002ygd.2_5'Flank|ARFRP1_uc002ygf.2_5'Flank|ARFRP1_uc002ygg.2_5'Flank|ARFRP1_uc011abh.1_5'Flank|ZGPAT_uc002ygi.2_Silent_p.L129L|ZGPAT_uc002ygj.2_Silent_p.L129L|ZGPAT_uc010gkk.1_Intron|ZGPAT_uc010gkl.1_Silent_p.L129L|ZGPAT_uc002ygm.2_Silent_p.L129L|ZGPAT_uc002ygn.3_RNA	NM_032527	NP_115916	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	129					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					aggaagagCTGAGTGGGACAA	0.537		NaN											0	0	0	0.004007	0	17	45									
LIPI	149998	broad.mit.edu	37	21	15561684	15561684	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:15561684C>T	uc002yjm.2	-	2	176	c.166G>A	c.(166-168)GAT>AAT	p.D56N	LIPI_uc010gkw.1_5'UTR	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	35					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		ATAAATAAATCTCTGAAGGAA	0.353		NaN											0	0	0	0.009718	0	40	153									
RBM11	54033	broad.mit.edu	37	21	15599290	15599290	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:15599290G>A	uc002yjo.3	+	5	564	c.522G>A	c.(520-522)CTG>CTA	p.L174L	RBM11_uc002yjn.3_Silent_p.L60L|RBM11_uc002yjp.3_Silent_p.L60L	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	174							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CTTCCTCACTGAATCATGTTC	0.453		NaN											0	0	0	0.01441	0	69	273									
RBM11	54033	broad.mit.edu	37	21	15599416	15599416	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:15599416G>A	uc002yjo.3	+	5	690	c.648G>A	c.(646-648)CTG>CTA	p.L216L	RBM11_uc002yjn.3_Silent_p.L102L|RBM11_uc002yjp.3_Silent_p.L102L	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	216							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CTTCCTCACTGAATCATGTTC	0.443		NaN											0	0	0	0.004482	0	8	395									
NRIP1	8204	broad.mit.edu	37	21	16338443	16338443	+	Missense_Mutation	SNP	G	G	T	rs61755058	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:16338443G>T	uc002yjx.2	-	4	2669	c.2071C>A	c.(2071-2073)CCA>ACA	p.P691T		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	691	Repression domain 2.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GGACCTGTTGGTTGACTACTA	0.398		NaN											1	0	3.62473e-10	0.012319	3.77431e-10	22	89									
NRIP1	8204	broad.mit.edu	37	21	16339706	16339706	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:16339706G>A	uc002yjx.2	-	4	1406	c.808C>T	c.(808-810)CTG>TTG	p.L270L		NM_003489	NP_003480	P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	270	LXXLL motif 4.|Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity				0				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TCGCTTGACAGAAGTAATGCT	0.463		NaN											0	0	0	0.01441	0	68	122									
APP	351	broad.mit.edu	37	21	27326925	27326925	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:27326925C>T	uc002ylz.2	-	13	1866	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K	APP_uc011acg.1_Missense_Mutation_p.E64K|APP_uc010glk.2_Missense_Mutation_p.E532K|APP_uc002yma.2_Missense_Mutation_p.E537K|APP_uc011ach.1_Missense_Mutation_p.E500K|APP_uc002ymb.2_Missense_Mutation_p.E481K|APP_uc010glj.2_Missense_Mutation_p.E425K|APP_uc011aci.1_Missense_Mutation_p.E446K	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	556	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				TGAATCTCCTCGGCCACTGCA	0.463		NaN											0	0	0	0.010729	0	12	25									
APP	351	broad.mit.edu	37	21	27423431	27423431	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:27423431C>G	uc002ylz.2	-	5	747	c.547G>C	c.(547-549)GAG>CAG	p.E183Q	APP_uc010glk.2_Missense_Mutation_p.E178Q|APP_uc002yma.2_Missense_Mutation_p.E183Q|APP_uc011ach.1_Missense_Mutation_p.E127Q|APP_uc002ymb.2_Missense_Mutation_p.E183Q|APP_uc010glj.2_Missense_Mutation_p.E127Q|APP_uc011aci.1_Missense_Mutation_p.E148Q|APP_uc011acj.1_Missense_Mutation_p.E183Q	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	183	Extracellular (Potential).|Zinc-binding.				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				CACACAAACTCTACCCCTCGG	0.512		NaN											0	0	0	0.001168	0	6	54									
GRIK1	2897	broad.mit.edu	37	21	30949385	30949385	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:30949385C>G	uc002yno.1	-	14	2493	c.2029G>C	c.(2029-2031)GAG>CAG	p.E677Q	GRIK1_uc002ynn.2_Missense_Mutation_p.E662Q|GRIK1_uc011acs.1_Missense_Mutation_p.E677Q|GRIK1_uc011act.1_Missense_Mutation_p.E538Q	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	677	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TCCATTCTCTCTACTGTCAAG	0.448		NaN											0	0	0	0.00278	0	24	105									
DNAJC28	54943	broad.mit.edu	37	21	34860800	34860800	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:34860800G>C	uc002yrv.2	-	2	1350	c.901C>G	c.(901-903)CAA>GAA	p.Q301E	DNAJC28_uc002yrw.2_Missense_Mutation_p.Q301E	NM_017833	NP_060303	Q9NX36	DJC28_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 28	301	Potential.						heat shock protein binding				0						ATGTTTTCTTGAAACTGCTCA	0.353		NaN											0	0	0	0.01441	0	103	125									
RCAN1	1827	broad.mit.edu	37	21	35895867	35895867	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:35895867G>C	uc002yue.2	-	2	466	c.394C>G	c.(394-396)CTG>GTG	p.L132V	RCAN1_uc002yuc.2_Missense_Mutation_p.L51V|RCAN1_uc002yud.2_5'UTR|RCAN1_uc002yub.2_Missense_Mutation_p.L77V|RCAN1_uc011adx.1_Missense_Mutation_p.L77V	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	132					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TCCTTTCCCAGAAACTCAGTC	0.453		NaN											0	0	0	0.010818	0	32	53									
RCAN1	1827	broad.mit.edu	37	21	35895991	35895991	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:35895991G>C	uc002yue.2	-	2	342	c.270C>G	c.(268-270)CTC>CTG	p.L90L	RCAN1_uc002yuc.2_Silent_p.L9L|RCAN1_uc002yud.2_5'UTR|RCAN1_uc002yub.2_Silent_p.L35L|RCAN1_uc011adx.1_Silent_p.L35L	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	90					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						ACGTCCTAAAGAGGGACTCAA	0.378		NaN											0	0	0	0.008361	0	30	59									
RUNX1	861	broad.mit.edu	37	21	36252962	36252962	+	Missense_Mutation	SNP	C	C	G	rs74315451		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:36252962C>G	uc002yuh.2	-	2	1897	c.319G>C	c.(319-321)GCT>CCT	p.A107P	RUNX1_uc002yui.2_Missense_Mutation_p.A107P|RUNX1_uc010gmu.2_Missense_Mutation_p.A134P|RUNX1_uc010gmv.2_Missense_Mutation_p.A134P|RUNX1_uc002yuj.3_Missense_Mutation_p.A2P|RUNX1_uc002yuk.3_Missense_Mutation_p.A134P|RUNX1_uc002yum.1_Missense_Mutation_p.A2P|RUNX1_uc010gmw.1_Missense_Mutation_p.A134P|RUNX1_uc002yuo.1_Missense_Mutation_p.A107P|RUNX1_uc002yur.1_Missense_Mutation_p.A2P	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	107	Runt.			A->T: Loss of heterodimerization.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.R107C(12)|p.R107H(2)		haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						TCATTGCCAGCCATCACAGTG	0.488		NaN	T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				0	0	0	0.007413	0	19	20									
DOPEY2	9980	broad.mit.edu	37	21	37642413	37642413	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:37642413C>T	uc002yvg.2	+	27	5669	c.5590C>T	c.(5590-5592)CAG>TAG	p.Q1864*	DOPEY2_uc011aeb.1_Nonsense_Mutation_p.Q1813*	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1864					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GGCCCAACCTCAGGCCTCTCT	0.527		NaN											0	0	0	0.01441	0	61	62									
ETS2	2114	broad.mit.edu	37	21	40191551	40191551	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:40191551G>A	uc002yxg.2	+	8	1132	c.936G>A	c.(934-936)GAG>GAA	p.E312E	ETS2_uc002yxf.2_Silent_p.E452E	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	312					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				CTTCCTTCGAGAGCTTCGAAG	0.547		NaN											0	0	0	0.001984	0	7	20									
MX2	4600	broad.mit.edu	37	21	42778893	42778893	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:42778893G>A	uc002yzf.1	+	13	1977	c.1873G>A	c.(1873-1875)GAA>AAA	p.E625K	MX2_uc002yzg.1_Missense_Mutation_p.E348K|MX2_uc010gop.1_Missense_Mutation_p.E107K	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	625	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CTCCTTTACTGAAATAGGCAT	0.488		NaN											0	0	0	0.010771	0	41	41									
MX1	4599	broad.mit.edu	37	21	42821118	42821118	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:42821118G>A	uc002yzh.2	+	16	2275	c.1328G>A	c.(1327-1329)AGA>AAA	p.R443K	MX1_uc002yzi.2_Missense_Mutation_p.R443K|MX1_uc010goq.2_Missense_Mutation_p.R443K	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	443					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				TATCGTGGTAGAGAGCTGCCA	0.383		NaN											0	0	0	0.012319	0	20	81									
UBASH3A	53347	broad.mit.edu	37	21	43867289	43867289	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:43867289G>C	uc002zbe.2	+	15	2007	c.1971G>C	c.(1969-1971)TGG>TGC	p.W657C	UBASH3A_uc002zbf.2_Missense_Mutation_p.W619C|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_3'UTR	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	657	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						GGAGGAACTGGATCTCAGGCA	0.527		NaN											0	0	0	0.004289	0	38	107									
UBASH3A	53347	broad.mit.edu	37	21	43867303	43867303	+	Nonstop_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:43867303G>T	uc002zbe.2	+	15	2021	c.1985G>T	c.(1984-1986)TGA>TTA	p.*662L	UBASH3A_uc002zbf.2_Nonstop_Mutation_p.*624L|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_3'UTR	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	662						cytosol|nucleus				ovary(3)	3						TCAGGCAACTGAGAGCCACGG	0.542		NaN											1	0	6.00712e-18	0.012213	6.34329e-18	34	98									
TRAPPC10	7109	broad.mit.edu	37	21	45503018	45503018	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:45503018G>C	uc002zea.2	+	14	2242	c.2073G>C	c.(2071-2073)ACG>ACC	p.T691T	TRAPPC10_uc010gpo.2_Silent_p.T402T|TRAPPC10_uc011afa.1_Silent_p.T110T	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	691					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CCTTGAACACGACTGGGATTA	0.547		NaN											0	0	0	0.00333	0	26	72									
TRAPPC10	7109	broad.mit.edu	37	21	45503079	45503079	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:45503079C>T	uc002zea.2	+	14	2303	c.2134C>T	c.(2134-2136)CTA>TTA	p.L712L	TRAPPC10_uc010gpo.2_Silent_p.L423L|TRAPPC10_uc011afa.1_Silent_p.L131L	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	712					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CAGCTCCTCTCTAGAGATGCC	0.557		NaN											0	0	0	0.01441	0	72	80									
TRAPPC10	7109	broad.mit.edu	37	21	45503092	45503092	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:45503092C>T	uc002zea.2	+	14	2316	c.2147C>T	c.(2146-2148)TCA>TTA	p.S716L	TRAPPC10_uc010gpo.2_Missense_Mutation_p.S427L|TRAPPC10_uc011afa.1_Missense_Mutation_p.S135L	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	716					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						GAGATGCCCTCAGGGGTGGCT	0.567		NaN											0	0	0	0.01441	0	79	91									
TRPM2	7226	broad.mit.edu	37	21	45789113	45789113	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr21:45789113G>A	uc002zet.1	+	6	871	c.658G>A	c.(658-660)GAG>AAG	p.E220K	TRPM2_uc002zeu.1_Missense_Mutation_p.E220K|TRPM2_uc002zew.1_Missense_Mutation_p.E220K|TRPM2_uc010gpt.1_Missense_Mutation_p.E220K|TRPM2_uc002zex.1_Missense_Mutation_p.E6K	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	220	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCAGGTAGGCGAGGCGGTGCG	0.682		NaN											0	0	0	0.001168	0	5	9									
CCT8L2	150160	broad.mit.edu	37	22	17072537	17072537	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:17072537C>T	uc002zlp.1	-	1	1164	c.904G>A	c.(904-906)GAG>AAG	p.E302K		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	302					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GTGAGGGTCTCCTCGTCGACC	0.493		NaN											0	0	0	0.007835	0	36	88									
PEX26	55670	broad.mit.edu	37	22	18566437	18566437	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:18566437G>A	uc002znp.3	+	4	815	c.606G>A	c.(604-606)GCG>GCA	p.A202A	TUBA8_uc002znr.2_Intron|PEX26_uc002znq.3_Silent_p.A202A|PEX26_uc002znt.2_Silent_p.A202A	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	202	Cytoplasmic (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						TTCACACAGCGAGGCAGCAGC	0.572		NaN											0	0	0	0.006122	0	15	24									
HIRA	7290	broad.mit.edu	37	22	19418988	19418988	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:19418988C>T	uc002zpf.1	-	1	232	c.12G>A	c.(10-12)CTG>CTA	p.L4L	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Silent_p.L4L|HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron|MRPL40_uc002zpg.2_5'Flank|MRPL40_uc002zph.2_5'Flank	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	4					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					AGGTCGGCTTCAGGAGCTTCA	0.557		NaN											0	0	0	0.00308	0	7	12									
SERPIND1	3053	broad.mit.edu	37	22	21141329	21141329	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:21141329G>A	uc002ztb.1	+	5	1542	c.1475G>A	c.(1474-1476)AGA>AAA	p.R492K	PI4KA_uc002zsz.3_Intron|SERPIND1_uc002ztc.2_Missense_Mutation_p.R520K	NM_000185	NP_000176	P05546	HEP2_HUMAN	heparin cofactor II precursor	492					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity				0	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	TTCATGGGAAGAGTGGCCAAC	0.562		NaN											0	0	0	0.004482	0	7	37									
SMARCB1	6598	broad.mit.edu	37	22	24159103	24159103	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:24159103G>A	uc002zyb.2	+	6	982	c.775G>A	c.(775-777)GAC>AAC	p.D259N	SMARCB1_uc002zya.2_Intron|SMARCB1_uc002zyc.2_Missense_Mutation_p.D250N|SMARCB1_uc002zyd.2_Missense_Mutation_p.D268N	NM_003073	NP_003064	Q12824	SNF5_HUMAN	SWI/SNF related, matrix associated, actin	259	2.|2 X approximate tandem repeats.				cell cycle|chromatin remodeling|DNA integration|interspecies interaction between organisms|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|retroviral genome replication|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleolus|nucleoplasm|SWI/SNF complex	p53 binding	p.?(3)|p.D259fs*26(1)|p.E210fs*15(1)		soft_tissue(193)|central_nervous_system(172)|haematopoietic_and_lymphoid_tissue(23)|meninges(5)|skin(5)|bone(4)|ovary(2)|endometrium(1)|lung(1)|pancreas(1)	407		Medulloblastoma(6;2.2e-09)|all_neural(6;2.73e-05)				GGACCAGTCAGACCAGCGCGT	0.582		NaN	D|N|F|S		malignant rhabdoid 	malignant rhabdoid			Rhabdoid_Predisposition_syndrome|Schwannomatosis				0	0	0	0.013537	0	11	40									
UPB1	51733	broad.mit.edu	37	22	24917979	24917979	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:24917979C>T	uc003aaf.2	+	8	1020	c.899C>T	c.(898-900)TCG>TTG	p.S300L	UPB1_uc003aae.2_Missense_Mutation_p.S232L|UPB1_uc011ajt.1_Missense_Mutation_p.S300L	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	300	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)					GAGTTTACCTCGGGAGATGGA	0.522		NaN									OREG0026411	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	21									
LRP5L	91355	broad.mit.edu	37	22	25747768	25747768	+	Nonstop_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:25747768A>T	uc003abs.2	-	4	3222	c.757T>A	c.(757-759)TGA>AGA	p.*253R	LRP5L_uc011ajz.1_Nonstop_Mutation_p.*253R|LRP5L_uc010guw.1_Silent_p.A223A	NM_182492	NP_872298	A4QPB2	LRP5L_HUMAN	low density lipoprotein receptor-related protein	253											0						CATGTCACTCAGCAGTTCCAG	0.577		NaN											0	0	0	0.008871	0	18	49									
NEFH	4744	broad.mit.edu	37	22	29886470	29886470	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:29886470G>C	uc003afo.2	+	4	2912	c.2841G>C	c.(2839-2841)AAG>AAC	p.K947N	NEFH_uc003afp.2_Missense_Mutation_p.R13T	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	953	Tail.				cell death|nervous system development	neurofilament					0						CAGCAGAGAAGAAGGAGGCAG	0.512		NaN											0	0	0	0.00245	0	15	31									
ASCC2	84164	broad.mit.edu	37	22	30198101	30198101	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:30198101C>T	uc003agr.2	-	14	1555	c.1450G>A	c.(1450-1452)GAG>AAG	p.E484K	ASCC2_uc003ags.2_Intron|ASCC2_uc003agt.2_Missense_Mutation_p.E484K|ASCC2_uc011akr.1_Missense_Mutation_p.E408K	NM_032204	NP_115580	Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit	484	CUE.				regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			ATGAAGCCCTCACCAAGGTCT	0.617		NaN											0	0	0	0.001984	0	5	33									
MTP18	51537	broad.mit.edu	37	22	30822716	30822716	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:30822716G>A	uc003ahw.1	+	2	227	c.79G>A	c.(79-81)GAG>AAG	p.E27K	SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Intron|MTP18_uc003ahv.1_Missense_Mutation_p.E189K|MTP18_uc010gvy.1_Intron|MTP18_uc003ahx.1_Missense_Mutation_p.E27K	NM_016498	NP_057582	Q9UDX5	MTFP1_HUMAN	mitochondrial protein 18 kDa isoform a	27					apoptosis|carbon utilization	integral to membrane|mitochondrial inner membrane	carbonate dehydratase activity|zinc ion binding				0						CTATGCCAATGAGGTGGGCGA	0.478		NaN									OREG0026460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	7	19									
PATZ1	23598	broad.mit.edu	37	22	31738885	31738885	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:31738885G>A	uc003akq.2	-	2	1994	c.1333C>T	c.(1333-1335)CAG>TAG	p.Q445*	PATZ1_uc003akp.2_Nonsense_Mutation_p.Q445*|PATZ1_uc003akr.2_Nonsense_Mutation_p.Q445*|PATZ1_uc003aks.2_Nonsense_Mutation_p.Q445*	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	445	C2H2-type 5.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						GCCCCTACCTGACACTTGTGA	0.582		NaN											0	0	0	0.004656	0	23	89									
SLC5A1	6523	broad.mit.edu	37	22	32495203	32495203	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:32495203C>T	uc003amc.2	+	12	1546	c.1314C>T	c.(1312-1314)ATC>ATT	p.I438I	SLC5A1_uc011alz.1_Silent_p.I311I	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	438	Helical; (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						GCATCAGCATCGCCTGGGTGC	0.453		NaN											0	0	0	0.011902	0	47	127									
APOL5	80831	broad.mit.edu	37	22	36122285	36122285	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:36122285G>A	uc003aof.2	+	3	170	c.170G>A	c.(169-171)TGG>TAG	p.W57*		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	57					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						TGCCAGAGTTGGAAAATTAAC	0.453		NaN											0	0	0	0.00245	0	14	54									
APOL5	80831	broad.mit.edu	37	22	36122301	36122301	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:36122301G>A	uc003aof.2	+	3	186	c.186G>A	c.(184-186)TTG>TTA	p.L62L		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	62					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						TTAACAATTTGATGTCAACTG	0.458		NaN											0	0	0	0.012213	0	30	34									
MYH9	4627	broad.mit.edu	37	22	36690984	36690984	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:36690984C>T	uc003apg.2	-	27	3855	c.3624G>A	c.(3622-3624)ACG>ACA	p.T1208T		NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	1208	Potential.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						GCACCCGCTTCGTCTGCTCCA	0.587		NaN	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				0	0	0	0.013726	0	31	74									
NCF4	4689	broad.mit.edu	37	22	37268449	37268449	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:37268449C>G	uc003apy.3	+	7	793	c.609C>G	c.(607-609)ATC>ATG	p.I203M	NCF4_uc003apz.3_Missense_Mutation_p.I203M	NM_000631	NP_000622	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4 isoform 1	203	SH3.				cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			ovary(1)	1						TCAGTCGGATCAACAAAGACT	0.254		NaN											0	0	0	0.005443	0	26	62									
CSF2RB	1439	broad.mit.edu	37	22	37331726	37331726	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:37331726C>T	uc003aqa.3	+	12	1678	c.1461C>T	c.(1459-1461)TTC>TTT	p.F487F	CSF2RB_uc003aqc.3_Silent_p.F493F	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	487	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GCCACCTGTTCCAGGTAGGAA	0.612		NaN											0	0	0	0.000602	0	5	14									
CYTH4	27128	broad.mit.edu	37	22	37688736	37688736	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:37688736G>A	uc003arf.2	+	2	210	c.94G>A	c.(94-96)GAC>AAC	p.D32N	CYTH4_uc003ard.3_Missense_Mutation_p.D32N|CYTH4_uc003are.2_Missense_Mutation_p.D32N|CYTH4_uc011amw.1_5'UTR|CYTH4_uc010gxe.2_Intron	NM_013385	NP_037517	Q9UIA0	CYH4_HUMAN	cytohesin 4	32	Potential.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GCTCCTGGAGGACATCCAGGT	0.617		NaN											0	0	0	0.014323	0	23	22									
PDGFB	5155	broad.mit.edu	37	22	39629484	39629484	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:39629484G>C	uc003axf.2	-	3	1195	c.206C>G	c.(205-207)TCT>TGT	p.S69C	PDGFB_uc003axe.2_Missense_Mutation_p.S54C	NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	69					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)	CTCGCCTCCAGAGTGGGAGCG	0.607		NaN	T	COL1A1	DFSP								0	0	0	0.006214	0	10	34									
PDGFB	5155	broad.mit.edu	37	22	39639936	39639936	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:39639936G>A	uc003axf.2	-	1	1022	c.33C>T	c.(31-33)CTC>CTT	p.L11L		NM_002608	NP_002599	P01127	PDGFB_HUMAN	platelet-derived growth factor beta isoform 1	11					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(1)	373	Melanoma(58;0.04)				Becaplermin(DB00102)	GGTAGCAGCAGAGAGACAGGA	0.582		NaN	T	COL1A1	DFSP								0	0	0	0.004672	0	3	8									
CACNA1I	8911	broad.mit.edu	37	22	40061947	40061947	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40061947C>T	uc003ayc.2	+	23	4040	c.4040C>T	c.(4039-4041)TCG>TTG	p.S1347L	CACNA1I_uc003ayd.2_Missense_Mutation_p.S1312L|CACNA1I_uc003aye.2_Missense_Mutation_p.S1262L|CACNA1I_uc003ayf.2_Missense_Mutation_p.S1227L	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1347	Extracellular (Potential).|III.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	ACCAACCGCTCGGACTGCATG	0.597		NaN											0	0	0	0.004482	0	8	23									
CACNA1I	8911	broad.mit.edu	37	22	40078519	40078519	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40078519G>A	uc003ayc.2	+	35	5683	c.5683G>A	c.(5683-5685)GAG>AAG	p.E1895K	CACNA1I_uc003ayd.2_Missense_Mutation_p.E1860K|CACNA1I_uc003aye.2_Missense_Mutation_p.E1810K|CACNA1I_uc003ayf.2_Missense_Mutation_p.E1775K	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	1895	Cytoplasmic (Potential).				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGACCCACCTGAGCCCATGCG	0.607		NaN											0	0	0	0.007291	0	23	50									
GRAP2	9402	broad.mit.edu	37	22	40343156	40343156	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40343156G>A	uc003ayh.1	+	2	309	c.46G>A	c.(46-48)GAA>AAA	p.E16K	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Intron|GRAP2_uc011aon.1_Intron|GRAP2_uc010gya.1_Missense_Mutation_p.E16K|GRAP2_uc011aoo.1_5'UTR|GRAP2_uc011aop.1_Missense_Mutation_p.E16K|GRAP2_uc011aoq.1_Intron|GRAP2_uc003ayj.1_Missense_Mutation_p.E16K	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	16	SH3 1.				cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AGGTGAGGATGAACTGAGCTT	0.498		NaN											0	0	0	0.010504	0	20	48									
TNRC6B	23112	broad.mit.edu	37	22	40662285	40662285	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40662285C>G	uc011aor.1	+	5	2262	c.2051C>G	c.(2050-2052)TCA>TGA	p.S684*	TNRC6B_uc003aym.2_Intron|TNRC6B_uc003ayn.3_Nonsense_Mutation_p.S684*|TNRC6B_uc003ayo.2_Nonsense_Mutation_p.S488*	NM_001162501	NP_001155973	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B isoform 1	684					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding				0						GGGGAGCTCTCAGCCTCTACA	0.552		NaN											0	0	0	0.004672	0	3	4									
SGSM3	27352	broad.mit.edu	37	22	40805700	40805700	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:40805700G>A	uc003ayu.1	+	22	2396	c.2187G>A	c.(2185-2187)CTG>CTA	p.L729L	SGSM3_uc011aot.1_Silent_p.L640L|SGSM3_uc010gyd.1_Silent_p.L800L	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	729					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						AGCAGCCCCTGAAGGAGGGCG	0.662		NaN											0	0	0	0.010504	0	16	38									
PKDREJ	10343	broad.mit.edu	37	22	46654093	46654093	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:46654093C>G	uc003bhh.2	-	1	5127	c.5127G>C	c.(5125-5127)CTG>CTC	p.L1709L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	1709	Helical; (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AACTCAGAAACAGGAGTGCTC	0.403		NaN											0	0	0	0.006214	0	9	89									
TRABD	80305	broad.mit.edu	37	22	50635718	50635718	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr22:50635718G>A	uc003bjq.1	+	6	555	c.469G>A	c.(469-471)GCA>ACA	p.A157T	TRABD_uc003bjr.1_Missense_Mutation_p.A41T|TRABD_uc003bjs.1_Missense_Mutation_p.A157T|TRABD_uc003bjt.1_Missense_Mutation_p.A157T|TRABD_uc003bju.1_Missense_Mutation_p.A157T|TRABD_uc003bjv.2_Missense_Mutation_p.A157T|TRABD_uc003bjw.1_Missense_Mutation_p.A157T	NM_025204	NP_079480	Q9H4I3	TRABD_HUMAN	TraB domain containing	157											0		all_cancers(38;1.07e-07)|all_epithelial(38;9.6e-07)|all_lung(38;0.00141)|Breast(42;0.00387)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		LUAD - Lung adenocarcinoma(64;0.105)		GAAGGTGTCTGCACACATCAC	0.662		NaN											0	0	0	0.008291	0	11	37									
BHLHE40	8553	broad.mit.edu	37	3	5022016	5022016	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:5022016G>A	uc003bqf.2	+	3	488	c.181G>A	c.(181-183)GAG>AAG	p.E61K	uc003bqe.1_5'Flank|uc010hce.1_5'Flank|BHLHE40_uc011asw.1_5'UTR	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	61	Basic motif.					Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCGGCTCATCGAGAAAAAGAG	0.567		NaN									OREG0015367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00874	0	38	7									
SRGAP3	9901	broad.mit.edu	37	3	9055453	9055453	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9055453C>G	uc003brf.1	-	16	2563	c.1887G>C	c.(1885-1887)GTG>GTC	p.V629V	SRGAP3_uc003brg.1_Silent_p.V605V	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	629	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		ATCTCATGACCACAATGACCA	0.552		NaN	T	RAF1	pilocytic astrocytoma								0	0	0	0.004482	0	6	111									
CAMK1	8536	broad.mit.edu	37	3	9803376	9803376	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9803376G>A	uc003bst.2	-	6	673	c.495C>T	c.(493-495)CTC>CTT	p.L165L	OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|CAMK1_uc003bsu.2_RNA|CAMK1_uc003bss.2_5'Flank|uc003bsv.1_RNA	NM_003656	NP_003647	Q14012	KCC1A_HUMAN	calcium/calmodulin-dependent protein kinase I	165	Protein kinase.				cell differentiation|nervous system development|positive regulation of muscle cell differentiation|signal transduction	cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|skin(1)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.0475)		CCATCTTGGAGAGGCCAAAGT	0.602		NaN											0	0	0	0.00623	0	40	86									
IL17RC	84818	broad.mit.edu	37	3	9959040	9959040	+	Missense_Mutation	SNP	G	G	A	rs112532783	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9959040G>A	uc003bua.2	+	1	277	c.41G>A	c.(40-42)CGA>CAA	p.R14Q	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_RNA|IL17RC_uc011ato.1_RNA|IL17RC_uc010hcs.2_Missense_Mutation_p.R14Q|IL17RC_uc003btz.2_Missense_Mutation_p.R14Q|IL17RC_uc011atp.1_5'UTR|IL17RC_uc003bud.2_5'UTR|IL17RC_uc003bub.2_Missense_Mutation_p.R14Q|IL17RC_uc010hct.2_Missense_Mutation_p.R14Q|IL17RC_uc010hcu.2_Missense_Mutation_p.R14Q|IL17RC_uc010hcv.2_Missense_Mutation_p.R14Q|IL17RC_uc011atq.1_Missense_Mutation_p.R14Q|IL17RC_uc003buc.2_5'UTR	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	14						integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						GCACTGGGCCGAAGCCCAGTG	0.657		NaN											0	0	0	0.00499	0	12	70									
CRELD1	78987	broad.mit.edu	37	3	9986069	9986069	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9986069G>A	uc003bug.2	+	11	1187	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K	CIDEC_uc003bto.2_Intron|CRELD1_uc003buf.2_Silent_p.Q421Q|CRELD1_uc003buh.2_Missense_Mutation_p.E357K|CRELD1_uc003bui.2_Missense_Mutation_p.E357K|CRELD1_uc003buj.2_RNA	NM_001077415	NP_001070883	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1 isoform 3	357	Extracellular (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			ovary(1)	1						CTTCTTCTCAGAGATGACAGA	0.547		NaN											0	0	0	0.006999	0	38	288									
PRRT3	285368	broad.mit.edu	37	3	9988960	9988960	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:9988960C>T	uc003bul.2	-	4	2027	c.1897G>A	c.(1897-1899)GCC>ACC	p.A633T	CIDEC_uc003bto.2_Intron|PRRT3_uc003buk.2_RNA	NM_207351	NP_997234	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3 precursor	633	Cytoplasmic (Potential).					integral to membrane					0						CCCGGGCTGGCATCCCAGCCC	0.766		NaN											0	0	0	0.001984	0	6	0									
FANCD2	2177	broad.mit.edu	37	3	10070355	10070355	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:10070355G>C	uc003buw.2	+	2	92	c.14G>C	c.(13-15)AGA>ACA	p.R5T	CIDEC_uc003bto.2_5'Flank|FANCD2_uc003bux.1_Missense_Mutation_p.R5T|FANCD2_uc003buy.1_Missense_Mutation_p.R5T|CIDECP_uc003bus.2_5'Flank|CIDECP_uc003but.2_5'Flank|CIDECP_uc003buu.1_5'Flank|FANCD2_uc003buv.2_Missense_Mutation_p.R5T	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	5	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GTTTCCAAAAGAAGACTGTCA	0.388		NaN	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.001984	0	7	105									
FANCD2	2177	broad.mit.edu	37	3	10127604	10127604	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:10127604C>T	uc003buw.2	+	33	3411	c.3333C>T	c.(3331-3333)CTC>CTT	p.L1111L	FANCD2_uc003bux.1_Silent_p.L1111L|FANCD2_uc003buy.1_Silent_p.L1111L|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1111					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AGGAACTACTCAGGTGAGTCA	0.428		NaN	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.01441	0	179	27									
IQSEC1	9922	broad.mit.edu	37	3	12950806	12950806	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:12950806C>T	uc003bxt.2	-	11	2596	c.2587G>A	c.(2587-2589)GAA>AAA	p.E863K	IQSEC1_uc003bxu.3_Missense_Mutation_p.E741K|IQSEC1_uc011auw.1_Missense_Mutation_p.E849K	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	863	PH.|Potential.				regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						TCTTGGACTTCCGCAATGGAC	0.537		NaN											0	0	0	0.01441	0	68	174									
FGD5	152273	broad.mit.edu	37	3	14949214	14949214	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:14949214G>T	uc003bzc.2	+	10	3442	c.3332G>T	c.(3331-3333)GGA>GTA	p.G1111V	FGD5_uc011avk.1_Missense_Mutation_p.G1111V|FGD5_uc003bzd.2_Missense_Mutation_p.G189V	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1111					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						CTCCAGCCAGGAAGGGTGAGT	0.642		NaN											1	0	1.12685e-05	0.004482	1.1518e-05	4	22									
STAC	6769	broad.mit.edu	37	3	36570456	36570456	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:36570456G>C	uc003cgh.1	+	10	1128	c.1089G>C	c.(1087-1089)CAG>CAC	p.Q363H	STAC_uc011aya.1_Missense_Mutation_p.Q302H	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	363					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						AACAGGGGCAGATAACACTGA	0.343		NaN											0	0	0	0.003954	0	24	24									
EPM2AIP1	9852	broad.mit.edu	37	3	37033664	37033664	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:37033664G>A	uc003cgk.2	-	1	1132	c.905C>T	c.(904-906)TCC>TTC	p.S302F	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	302						endoplasmic reticulum					0						TATCCATTCGGATATGGTATT	0.393		NaN											0	0	0	0.008871	0	20	82									
XYLB	9942	broad.mit.edu	37	3	38415956	38415956	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:38415956C>T	uc003cic.2	+	11	960	c.851C>T	c.(850-852)TCG>TTG	p.S284L	XYLB_uc011ayp.1_Missense_Mutation_p.S147L|XYLB_uc003cid.1_Missense_Mutation_p.S206L	NM_005108	NP_005099	O75191	XYLB_HUMAN	xylulokinase	284					D-xylose metabolic process|generation of precursor metabolites and energy|xylulose catabolic process		ATP binding|xylulokinase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.00372)|Kidney(284;0.00405)		TTCTCAGCGTCGCTGGCAGGC	0.587		NaN											0	0	0	0.003271	0	23	16									
CX3CR1	1524	broad.mit.edu	37	3	39307491	39307491	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:39307491C>G	uc003cjl.2	-	2	602	c.510G>C	c.(508-510)CAG>CAC	p.Q170H		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	170	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CATTTTCTTTCTGCTTTGTGA	0.547		NaN											0	0	0	0.00874	0	41	91									
ENTPD3	956	broad.mit.edu	37	3	40456182	40456182	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:40456182G>A	uc003ckd.3	+	6	540	c.448G>A	c.(448-450)GAA>AAA	p.E150K	ENTPD3_uc010hhy.2_Missense_Mutation_p.E150K|uc003cke.3_Intron	NM_001248	NP_001239	O75355	ENTP3_HUMAN	ectonucleoside triphosphate diphosphohydrolase	150	Extracellular (Potential).					integral to membrane	ATP binding|hydrolase activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0605)|Kidney(284;0.0758)		GTTGCAAAATGAAACAGCAGC	0.423		NaN											0	0	0	0.01441	0	55	53									
CTNNB1	1499	broad.mit.edu	37	3	41266101	41266101	+	Missense_Mutation	SNP	C	C	T	rs121913400		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:41266101C>T	uc010hia.1	+	4	254	c.98C>T	c.(97-99)TCT>TTT	p.S33F	CTNNB1_uc003ckp.2_Missense_Mutation_p.S33F|CTNNB1_uc003ckq.2_Missense_Mutation_p.S33F|CTNNB1_uc003ckr.2_Missense_Mutation_p.S33F|CTNNB1_uc011azf.1_Missense_Mutation_p.S26F|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	33			S -> F (in PTR, MDB and hepatocellular carcinoma).|Missing (in hepatocellular carcinoma).|S -> Y (in colorectal cancer and PTR; enhances transactivation of target genes).|S -> L (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S33C(131)|p.S33F(79)|p.A5_A80del(63)|p.S33Y(52)|p.S33P(37)|p.S33A(14)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.Q28_H134del(5)|p.S33L(4)|p.W25_I140del(4)|p.S33N(3)|p.S23_S33del(3)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32_S47del(2)|p.W25_H36del(2)|p.Y30_S33del(2)|p.V22_S33del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.S33T(1)|p.S33S(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.S29_H36del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.W25_I35del(1)|p.V22_G80>NNNNN(1)|p.A5_I35del(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.W25_S33del(1)|p.V22_T102del(1)|p.S33_G34del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.E9_A80del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.D32_H36>D(1)|p.S33_G34insGTS(1)|p.P16_K133del(1)|p.A5_T59del(1)|p.A20_I35del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.W25_A80del(1)|p.M8_A80del(1)|p.S33_S37del(1)|p.E9_I140del(1)|p.D32_S33insS(1)|p.S33_G34insS(1)|p.Y30_T40del(1)|p.S33_G34insGI(1)|p.M1_T42del(1)|p.A5_Q143>E(1)|p.A5_Q72del(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.S23_I35del(1)|p.V22_S71>A(1)|p.V22_Y64del(1)|p.A20_Q72del(1)|p.A20_S111del(1)|p.D32_H36del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	TACCTGGACTCTGGAATCCAT	0.488	S33C(SKMEL1_SKIN)|S33F(SW1573_LUNG)|S33Y(SW48_LARGE_INTESTINE)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				0	0	0	0.001984	0	7	31									
ZNF197	10168	broad.mit.edu	37	3	44684773	44684773	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:44684773G>T	uc003cnm.2	+	6	2357	c.2151G>T	c.(2149-2151)ATG>ATT	p.M717I	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	717	C2H2-type 13.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		CCTTTATTATGAGCAAAAGTT	0.423		NaN											1	0	5.73332e-34	0.01441	6.08376e-34	65	88									
ZNF35	7584	broad.mit.edu	37	3	44700379	44700379	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:44700379G>T	uc003cnq.2	+	4	745	c.524G>T	c.(523-525)AGA>ATA	p.R175I	ZNF35_uc003cnr.2_Missense_Mutation_p.R15I	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	175	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		AAAGATTTCAGACAAGTGATA	0.383		NaN											1	0	3.12436e-70	0.01441	3.32673e-70	109	38									
CLEC3B	7123	broad.mit.edu	37	3	45077285	45077285	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:45077285G>A	uc003cok.3	+	3	574	c.478G>A	c.(478-480)GAG>AAG	p.E160K	CLEC3B_uc003col.2_Missense_Mutation_p.E118K	NM_003278	NP_003269	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	160	C-type lectin.				skeletal system development	extracellular space	protein binding|sugar binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGGGAGACTGAGATCACCGC	0.662		NaN											0	0	0	0.005443	0	23	10									
KLHL18	23276	broad.mit.edu	37	3	47378043	47378043	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:47378043T>C	uc003crd.2	+	7	1043	c.917T>C	c.(916-918)GTG>GCG	p.V306A	KLHL18_uc003crc.2_Missense_Mutation_p.V306A|KLHL18_uc011bav.1_Missense_Mutation_p.V194A|KLHL18_uc010hjq.1_Missense_Mutation_p.V162A	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	306	Kelch 1.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		CTGAATGTGGTGGAAGTGTTC	0.478		NaN											0	0	0	0.008361	0	30	14									
SMARCC1	6599	broad.mit.edu	37	3	47676775	47676775	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:47676775C>T	uc003crq.2	-	24	2669	c.2551G>A	c.(2551-2553)GAT>AAT	p.D851N	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Missense_Mutation_p.D742N	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	851	Glu-rich.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TTCCCAGTATCACTTTCTCTT	0.433		NaN											0	0	0	0.004289	0	39	20									
ZNF589	51385	broad.mit.edu	37	3	48309504	48309504	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48309504C>T	uc003csl.3	+	4	389	c.323C>T	c.(322-324)CCA>CTA	p.P108L	ZNF589_uc010hjt.1_Missense_Mutation_p.P105L|ZNF589_uc003csn.2_RNA|ZNF589_uc011bbg.1_Missense_Mutation_p.P107L|ZNF589_uc003csm.2_Intron	NM_016089	NP_057173	Q86UQ0	ZN589_HUMAN	zinc finger protein 589	108	KRAB.				regulation of transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000649)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CATCCTATTCCAGGTTTCCAT	0.507		NaN											0	0	0	0.004007	0	17	60									
PLXNB1	5364	broad.mit.edu	37	3	48447188	48447188	+	Silent	SNP	G	G	A	rs143335184		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48447188G>A	uc003csw.2	-	37	6516	c.6246C>T	c.(6244-6246)CTC>CTT	p.L2082L	PLXNB1_uc003cst.2_Silent_p.L532L|PLXNB1_uc003csu.2_Silent_p.L1899L|PLXNB1_uc003csx.2_Silent_p.L2082L	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	2082	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTCGCGCCCCGAGGTCTCCGG	0.617		NaN											0	0	0	0.00308	0	7	17									
CCDC51	79714	broad.mit.edu	37	3	48474369	48474369	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48474369C>T	uc003csz.2	-	4	806	c.685G>A	c.(685-687)GAG>AAG	p.E229K	PLXNB1_uc003csx.2_5'Flank|CCDC51_uc003cta.2_Missense_Mutation_p.E120K|CCDC51_uc003ctb.2_Missense_Mutation_p.E120K|CCDC51_uc003ctc.2_Missense_Mutation_p.E229K|CCDC51_uc003ctd.2_Missense_Mutation_p.E120K	NM_024661	NP_078937	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	229						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GCCTTCAGCTCCTGTAGTCGC	0.597		NaN											0	0	0	0.00333	0	26	89									
ATRIP	84126	broad.mit.edu	37	3	48506933	48506933	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48506933C>G	uc003ctf.1	+	13	2388	c.2356C>G	c.(2356-2358)CCC>GCC	p.P786A	ATRIP_uc011bbj.1_Missense_Mutation_p.P659A|ATRIP_uc003ctg.1_Missense_Mutation_p.P759A|TREX1_uc010hjy.2_5'UTR|TREX1_uc003ctj.2_5'UTR|TREX1_uc003ctk.2_5'Flank|TREX1_uc010hjz.2_5'Flank|TREX1_uc010hka.2_5'Flank	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	786					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGTGGAAGACCCCGAGGTGGA	0.587		NaN						Other_conserved_DNA_damage_response_genes			OREG0015557	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	13	27									
COL7A1	1294	broad.mit.edu	37	3	48602351	48602351	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48602351G>A	uc003ctz.2	-	117	8684	c.8683C>T	c.(8683-8685)CGG>TGG	p.R2895W	UCN2_uc003cty.1_5'Flank	NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2895	Nonhelical region (NC2).|BPTI/Kunitz inhibitor.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTCACAGCCCGATGGTACCAG	0.622		NaN											0	0	0	0.004007	0	13	69									
COL7A1	1294	broad.mit.edu	37	3	48626328	48626328	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48626328G>C	uc003ctz.2	-	18	2416	c.2415C>G	c.(2413-2415)TAC>TAG	p.Y805*		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	805	Nonhelical region (NC1).|Fibronectin type-III 7.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGGCCAGTCTGTAAGCTGTGG	0.617		NaN											0	0	0	0.008291	0	9	42									
CELSR3	1951	broad.mit.edu	37	3	48664437	48664437	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48664437C>G	uc003cuf.1	-	53	12103	c.12103G>C	c.(12103-12105)GAC>CAC	p.D4035H	SLC26A6_uc003cug.2_Missense_Mutation_p.D628H|SLC26A6_uc003cuh.2_Missense_Mutation_p.D649H|SLC26A6_uc010hke.2_Missense_Mutation_p.D481H|SLC26A6_uc003cuk.2_Missense_Mutation_p.D541H|SLC26A6_uc003cui.2_Missense_Mutation_p.D648H|SLC26A6_uc003cuj.2_Missense_Mutation_p.D630H|SLC26A6_uc011bbp.1_Missense_Mutation_p.D613H	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCCTTGGAGTCTTCTTGACCA	0.592		NaN											0	0	0	0.005443	0	19	107									
CELSR3	1951	broad.mit.edu	37	3	48671065	48671065	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:48671065C>T	uc003cuf.1	-	37	10209	c.10209G>A	c.(10207-10209)CCG>CCA	p.P3403P	SLC26A6_uc003cug.2_5'UTR|SLC26A6_uc003cuh.2_Silent_p.P9P|SLC26A6_uc010hke.2_5'UTR|SLC26A6_uc003cuk.2_Silent_p.P9P|SLC26A6_uc003cui.2_Silent_p.P9P|SLC26A6_uc003cuj.2_Silent_p.P9P|SLC26A6_uc011bbp.1_Silent_p.P9P	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGTGTCCCTCGGTCTGGGGT	0.577		NaN											0	0	0	0.01441	0	63	71									
WDR6	11180	broad.mit.edu	37	3	49044905	49044905	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49044905C>T	uc003cvj.2	+	1	269	c.131C>T	c.(130-132)TCG>TTG	p.S44L	WDR6_uc011bbx.1_Missense_Mutation_p.S44L|WDR6_uc011bby.1_Missense_Mutation_p.S44L|WDR6_uc010hkn.2_5'UTR|WDR6_uc011bbz.1_5'Flank	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	14					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CGGGCAACCTCGGAGCTTATA	0.627		NaN											0	0	0	0.001168	0	5	8									
WDR6	11180	broad.mit.edu	37	3	49050477	49050477	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49050477G>A	uc003cvj.2	+	2	1738	c.1600G>A	c.(1600-1602)GAC>AAC	p.D534N	WDR6_uc011bbx.1_Silent_p.V362V|WDR6_uc011bby.1_Intron|WDR6_uc010hkn.2_Missense_Mutation_p.D478N|WDR6_uc011bbz.1_Missense_Mutation_p.D453N	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	504	WD 8.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		ACCCCCAGGTGACTTCCTGGT	0.622		NaN											0	0	0	0.010729	0	10	36									
IMPDH2	3615	broad.mit.edu	37	3	49062461	49062461	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49062461G>C	uc003cvt.2	-	11	1255	c.1163C>G	c.(1162-1164)TCT>TGT	p.S388C		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	388	IMP binding.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	AGCCAGGAGAGAGCCCATCAT	0.577		NaN											0	0	0	0.013537	0	12	63									
QARS	5859	broad.mit.edu	37	3	49137494	49137494	+	Missense_Mutation	SNP	C	C	T	rs143072084	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49137494C>T	uc003cvx.2	-	14	1200	c.1195G>A	c.(1195-1197)GAG>AAG	p.E399K	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Missense_Mutation_p.E254K|QARS_uc003cvy.2_Missense_Mutation_p.E254K|QARS_uc011bce.1_Missense_Mutation_p.E388K	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	399					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGTGTGGCCTCGCCCTCTGAA	0.557		NaN											0	0	0	0.012319	0	20	82									
C3orf62	375341	broad.mit.edu	37	3	49314209	49314209	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49314209C>T	uc003cwn.2	-	1	300	c.97G>A	c.(97-99)GAA>AAA	p.E33K	C3orf62_uc003cwm.2_5'Flank	NM_198562	NP_940964	Q6ZUJ4	CC062_HUMAN	hypothetical protein LOC375341	33											0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTAACTCCTTCAAAGGCCCGG	0.527		NaN											0	0	0	0.004878	0	35	27									
TCTA	6988	broad.mit.edu	37	3	49449866	49449866	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49449866G>T	uc003cwv.3	+	1	228	c.7G>T	c.(7-9)GAG>TAG	p.E3*	RHOA_uc010hku.2_5'Flank|RHOA_uc003cwu.2_5'Flank	NM_022171	NP_071503	P57738	TCTA_HUMAN	T-cell leukemia translocation altered	3	Extracellular (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGTCATGGCGGAGTCCTGGTC	0.706		NaN											1	0	1.62849e-17	0.004007	1.71795e-17	14	16									
AMT	275	broad.mit.edu	37	3	49455127	49455127	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49455127G>A	uc003cww.2	-	9	1187	c.1058C>T	c.(1057-1059)TCC>TTC	p.S353F	AMT_uc011bcn.1_3'UTR|AMT_uc003cwx.2_Missense_Mutation_p.S353F|AMT_uc011bco.1_Missense_Mutation_p.S309F|AMT_uc003cwy.2_Missense_Mutation_p.S305F|AMT_uc011bcp.1_Missense_Mutation_p.S256F|AMT_uc011bcq.1_Missense_Mutation_p.S297F	NM_000481	NP_000472	P48728	GCST_HUMAN	aminomethyltransferase isoform 1 precursor	353					glycine catabolic process	mitochondrion	aminomethyltransferase activity|transaminase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CAGAGAGGGGGAGGGGCAGCC	0.587		NaN											0	0	0	0.007291	0	20	25									
APEH	327	broad.mit.edu	37	3	49718651	49718651	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49718651G>C	uc003cxf.2	+	15	1817	c.1417G>C	c.(1417-1419)GAG>CAG	p.E473Q	APEH_uc010hkw.1_Missense_Mutation_p.E473Q	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	473					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCCACCCCCAGAGCAAGAGAA	0.617		NaN											0	0	0	0.00632	0	26	27									
MST1	4485	broad.mit.edu	37	3	49724697	49724697	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:49724697A>T	uc003cxg.2	-	5	564	c.492T>A	c.(490-492)AAT>AAA	p.N164K	MST1_uc011bcs.1_Missense_Mutation_p.N164K|MST1_uc010hkx.2_Missense_Mutation_p.N85K|MST1_uc011bct.1_Missense_Mutation_p.N164K|MST1_uc011bcu.1_RNA|RNF123_uc003cxh.2_5'Flank	NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	150	Kringle 1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTTCCAGGCCATTCCGGAGAG	0.612		NaN											0	0	0	0.003163	0	15	22									
TMEM115	11070	broad.mit.edu	37	3	50396052	50396052	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:50396052G>A	uc003dan.1	-	1	888	c.443C>T	c.(442-444)GCA>GTA	p.A148V		NM_007024	NP_008955	Q12893	TM115_HUMAN	PL6 protein	148	Helical; (Potential).				negative regulation of cell proliferation	Golgi apparatus|integral to membrane|nucleus					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTGCTTGAGTGCCACCAGGAC	0.507		NaN											0	0	0	0.001855	0	14	14									
MANF	7873	broad.mit.edu	37	3	51426367	51426367	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:51426367G>A	uc003dbc.2	+	4	467	c.405G>A	c.(403-405)CTG>CTA	p.L135L	RBM15B_uc003dbd.2_5'Flank	NM_006010	NP_006001	P55145	MANF_HUMAN	mesencephalic astrocyte-derived neurotrophic	132					response to unfolded protein	extracellular region	growth factor activity				0						CAGTGGACCTGAAGAAGCTCC	0.527		NaN									OREG0015594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	4									
RAD54L2	23132	broad.mit.edu	37	3	51672281	51672281	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:51672281G>A	uc011bdt.1	+	11	1929	c.1804G>A	c.(1804-1806)GGT>AGT	p.G602S	RAD54L2_uc003dbh.2_Missense_Mutation_p.G193S|RAD54L2_uc011bdu.1_Missense_Mutation_p.G296S|RAD54L2_uc003dbj.2_5'UTR	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	602						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CCGGGACTGTGGTAGCAGCGG	0.522		NaN									OREG0015596	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	22	27									
ERC2	26059	broad.mit.edu	37	3	56114883	56114883	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:56114883C>G	uc003dhr.1	-	7	1859	c.1603G>C	c.(1603-1605)GAA>CAA	p.E535Q	ERC2_uc003dht.1_Missense_Mutation_p.E6Q	NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	535	Potential.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCCTTCACTTCTAACATATCT	0.368		NaN											0	0	0	0.012319	0	22	23									
CCDC66	285331	broad.mit.edu	37	3	56627024	56627024	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:56627024C>T	uc003dhz.2	+	8	1050	c.963C>T	c.(961-963)TTC>TTT	p.F321F	CCDC66_uc003dhy.2_5'UTR|CCDC66_uc003dhu.2_Silent_p.F287F|CCDC66_uc003dhx.2_RNA	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	321										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		AGCACCCTTTCAGTGCTGTGA	0.343		NaN											0	0	0	0.01441	0	49	147									
FLNB	2317	broad.mit.edu	37	3	58106996	58106996	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:58106996C>T	uc003djj.2	+	20	3057	c.2892C>T	c.(2890-2892)TTC>TTT	p.F964F	FLNB_uc010hne.2_Silent_p.F964F|FLNB_uc003djk.2_Silent_p.F964F|FLNB_uc010hnf.2_Silent_p.F964F|FLNB_uc003djl.2_Silent_p.F795F|FLNB_uc003djm.2_Silent_p.F795F	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	964	Filamin 8.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ATCAGGAGTTCACCGTTGATA	0.562		NaN											0	0	0	0.010771	0	44	139									
FLNB	2317	broad.mit.edu	37	3	58109098	58109098	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:58109098A>T	uc003djj.2	+	21	3570	c.3405A>T	c.(3403-3405)AAA>AAT	p.K1135N	FLNB_uc010hne.2_Missense_Mutation_p.K1135N|FLNB_uc003djk.2_Missense_Mutation_p.K1135N|FLNB_uc010hnf.2_Missense_Mutation_p.K1135N|FLNB_uc003djl.2_Missense_Mutation_p.K966N|FLNB_uc003djm.2_Missense_Mutation_p.K966N	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1135	Interaction with FBLP1.|Filamin 10.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ACCCCTCTAAAGTCGTGGCAT	0.592		NaN											0	0	0	0.01441	0	73	58									
PXK	54899	broad.mit.edu	37	3	58377553	58377553	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:58377553C>T	uc003djz.1	+	7	693	c.594C>T	c.(592-594)ATC>ATT	p.I198I	PXK_uc003djx.1_Silent_p.I198I|PXK_uc003djy.1_Silent_p.I181I|PXK_uc003dka.1_Silent_p.I198I|PXK_uc003dkb.1_Silent_p.I115I|PXK_uc003dkc.1_Silent_p.I181I|PXK_uc011bfe.1_Silent_p.I165I|PXK_uc010hnj.1_Silent_p.I165I|PXK_uc003dkd.1_Silent_p.I61I|PXK_uc010hnk.1_Intron	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	198	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		AGTGTCTAATCAAACTTCTGC	0.388		NaN											0	0	0	0.01441	0	75	82									
SYNPR	132204	broad.mit.edu	37	3	63600994	63600994	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:63600994C>T	uc003dlq.2	+	5	1004	c.635C>T	c.(634-636)TCA>TTA	p.S212L	SYNPR_uc003dlp.2_Missense_Mutation_p.S232L|SYNPR_uc011bfk.1_RNA|SYNPR_uc011bfl.1_RNA|SYNPR_uc010hnt.2_Missense_Mutation_p.S221L|SYNPR_uc011bfm.1_RNA	NM_144642	NP_653243	Q8TBG9	SYNPR_HUMAN	synaptoporin isoform 2	212	Cytoplasmic (Potential).|5 X approximate repeats.|1.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity				0				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		AGATATCTTTCAGATCCAATG	0.468		NaN											0	0	0	0.001168	0	6	26									
PRICKLE2	166336	broad.mit.edu	37	3	64142939	64142939	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:64142939C>T	uc003dmf.2	-	5	1085	c.499G>A	c.(499-501)GAG>AAG	p.E167K		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	167	LIM zinc-binding 1.					cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		ACCAGGAGCTCATTGCAGACA	0.577		NaN											0	0	0	0.012213	0	24	23									
KBTBD8	84541	broad.mit.edu	37	3	67054357	67054357	+	Silent	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:67054357T>C	uc003dmy.2	+	3	1019	c.966T>C	c.(964-966)AAT>AAC	p.N322N	KBTBD8_uc011bfv.1_Intron	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	322										ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		AACCACCAAATGACCTGAGAG	0.443		NaN											0	0	0	0.01441	0	71	77									
TMF1	7110	broad.mit.edu	37	3	69074854	69074854	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:69074854G>A	uc003dnn.2	-	15	3116	c.2869C>T	c.(2869-2871)CAT>TAT	p.H957Y	TMF1_uc011bfx.1_Missense_Mutation_p.H960Y	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	957					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GAGTGATCATGAGACTCATCC	0.368		NaN											0	0	0	0.010818	0	30	72									
UBA3	9039	broad.mit.edu	37	3	69112141	69112141	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:69112141G>T	uc003dno.2	-	9	705	c.685C>A	c.(685-687)CCA>ACA	p.P229T	UBA3_uc003dnq.2_Missense_Mutation_p.P215T|UBA3_uc011bfy.1_Missense_Mutation_p.P52T|UBA3_uc011bfz.1_Missense_Mutation_p.P52T	NM_003968	NP_003959	Q8TBC4	UBA3_HUMAN	ubiquitin-activating enzyme 3 isoform 1	229	Interaction with NEDD8.				protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		ACCTGTGGTGGATAAAGTTCC	0.388		NaN											1	0	8.27458e-37	0.01441	8.78895e-37	71	63									
FOXP1	27086	broad.mit.edu	37	3	71037150	71037150	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:71037150G>A	uc003dol.2	-	10	1464	c.1141C>T	c.(1141-1143)CAG>TAG	p.Q381*	FOXP1_uc003dom.2_Nonsense_Mutation_p.Q305*|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Nonsense_Mutation_p.Q381*|FOXP1_uc003dop.2_Nonsense_Mutation_p.Q381*|FOXP1_uc003doq.1_Nonsense_Mutation_p.Q380*|FOXP1_uc003doi.2_Nonsense_Mutation_p.Q281*|FOXP1_uc003doj.2_Nonsense_Mutation_p.Q281*|FOXP1_uc003dok.2_Nonsense_Mutation_p.Q194*|FOXP1_uc003dor.1_Nonsense_Mutation_p.Q159*	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	381					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		CTTACGGGCTGAGGGGCGGCT	0.493		NaN	T	PAX5	ALL								0	0	0	0.01441	0	69	194									
PROS1	5627	broad.mit.edu	37	3	93611869	93611869	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:93611869G>A	uc003drb.3	-	10	1404	c.1063C>T	c.(1063-1065)CGT>TGT	p.R355C	PROS1_uc010hoo.2_Missense_Mutation_p.R224C|PROS1_uc003dqz.3_Missense_Mutation_p.R224C	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	355	Laminin G-like 1.		R -> H (in PROS1D).		leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTTCCACCACGAAGTGCAATC	0.393		NaN											0	0	0	0.00308	0	8	120									
STX19	415117	broad.mit.edu	37	3	93733304	93733304	+	Silent	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:93733304T>C	uc003drh.1	-	2	1067	c.810A>G	c.(808-810)CTA>CTG	p.L270L	ARL13B_uc003drc.2_Intron|ARL13B_uc010hop.2_Intron|ARL13B_uc003drd.2_Intron|ARL13B_uc003dre.2_Intron|ARL13B_uc003drf.2_Intron|ARL13B_uc003drg.2_Intron	NM_001001850	NP_001001850	Q8N4C7	STX19_HUMAN	syntaxin 19	270	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity				0						ATTTTACAGCTAGTCCAAATT	0.328		NaN											0	0	0	0.005524	0	39	30									
MINA	84864	broad.mit.edu	37	3	97668720	97668720	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:97668720G>A	uc003drz.1	-	7	1534	c.1028C>T	c.(1027-1029)TCT>TTT	p.S343F	MINA_uc003dry.1_Missense_Mutation_p.S14F|MINA_uc003dsa.1_Missense_Mutation_p.S342F|MINA_uc003dsb.1_Missense_Mutation_p.S343F|MINA_uc003dsc.1_Missense_Mutation_p.S342F|MINA_uc010hpa.1_RNA	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	343					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						ATCTCCCGCAGAGTAAGGGGG	0.522		NaN											0	0	0	0.001855	0	11	60									
ABI3BP	25890	broad.mit.edu	37	3	100471769	100471769	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:100471769C>G	uc003dun.2	-	33	2936	c.2851G>C	c.(2851-2853)GAA>CAA	p.E951Q	ABI3BP_uc003duj.2_Missense_Mutation_p.E531Q|ABI3BP_uc003duk.2_Missense_Mutation_p.E660Q|ABI3BP_uc003dul.2_Missense_Mutation_p.E781Q|ABI3BP_uc011bhd.1_Missense_Mutation_p.E905Q|ABI3BP_uc003dum.2_Missense_Mutation_p.E362Q	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	951						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						AAGGGTCTTTCAGTCCAGATG	0.373		NaN											0	0	0	0.004878	0	36	40									
MYH15	22989	broad.mit.edu	37	3	108102561	108102561	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:108102561G>A	uc003dxa.1	-	41	5764	c.5707C>T	c.(5707-5709)CAA>TAA	p.Q1903*		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1903	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GAAAGGTATTGATTGGCTTGT	0.333		NaN											0	0	0	0.005443	0	28	102									
MYH15	22989	broad.mit.edu	37	3	108139937	108139937	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:108139937C>G	uc003dxa.1	-	29	3944	c.3887G>C	c.(3886-3888)AGT>ACT	p.S1296T		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1296	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TTACTTACCACTCTCACTCCA	0.463		NaN											0	0	0	0.013726	0	34	133									
KIAA2018	205717	broad.mit.edu	37	3	113377710	113377710	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:113377710G>A	uc003eam.2	-	7	3230	c.2819C>T	c.(2818-2820)TCA>TTA	p.S940L	KIAA2018_uc003eal.2_Missense_Mutation_p.S884L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	940					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TACATTGGCTGAAGCGCAGGG	0.418		NaN											0	0	0	0.01441	0	127	123									
DRD3	1814	broad.mit.edu	37	3	113850098	113850098	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:113850098C>T	uc003ebd.2	-	7	1296	c.873G>A	c.(871-873)GCG>GCA	p.A291A	DRD3_uc010hqn.1_Silent_p.A291A|DRD3_uc003ebb.1_Intron|DRD3_uc003ebc.1_Silent_p.A291A	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	291	Cytoplasmic.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	TGAGCTTGGGCGCTATGGTGG	0.542		NaN											0	0	0	0.008361	0	27	222									
RABL3	285282	broad.mit.edu	37	3	120424963	120424963	+	Splice_Site	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:120424963T>C	uc003edx.2	-	4	299	c.269_splice	c.e4-1	p.G90_splice		NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3						small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		AAATAATACCTAAAATAATCA	0.373		NaN											0	0	0	0.008291	0	11	38									
EAF2	55840	broad.mit.edu	37	3	121554153	121554153	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:121554153C>T	uc003een.2	+	1	120	c.21C>T	c.(19-21)TTC>TTT	p.F7F	IQCB1_uc010hre.1_5'Flank|IQCB1_uc003eek.2_5'Flank|IQCB1_uc010hrf.1_5'Flank|EAF2_uc003eem.2_RNA|EAF2_uc003eeo.2_5'UTR	NM_018456	NP_060926	Q96CJ1	EAF2_HUMAN	ELL associated factor 2	7					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	protein binding				0				GBM - Glioblastoma multiforme(114;0.0972)		CAGCGGGATTCTCACACCTAG	0.557		NaN											0	0	0	0.004007	0	12	16									
SEMA5B	54437	broad.mit.edu	37	3	122658317	122658317	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:122658317C>T	uc003efz.1	-	5	733	c.429G>A	c.(427-429)AGG>AGA	p.R143R	SEMA5B_uc011bju.1_Silent_p.R85R|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.R143R|SEMA5B_uc010hro.1_Silent_p.R85R|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	143	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		AGAGGTAGTTCCTGTGAAAAT	0.537		NaN											0	0	0	0.001984	0	7	36									
ROPN1	54763	broad.mit.edu	37	3	123699230	123699230	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:123699230G>A	uc003eha.2	-	3	440	c.99C>T	c.(97-99)CTC>CTT	p.L33L	ROPN1_uc003ehb.1_RNA|ROPN1_uc003ehc.1_RNA	NM_017578	NP_060048	Q9HAT0	ROP1A_HUMAN	ropporin	33	RIIa.				signal transduction		cAMP-dependent protein kinase regulator activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.148)		CCCACTGGATGAGGTCCTGCG	0.597		NaN											0	0	0	0.003954	0	11	25									
KLF15	28999	broad.mit.edu	37	3	126071555	126071555	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:126071555C>T	uc011bkk.1	-	2	393	c.211G>A	c.(211-213)GAG>AAG	p.E71K		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Kruppel-like factor 15	71						nucleus	DNA binding|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(114;0.147)		TCCTGGCTCTCGGTGCCCAGG	0.652		NaN											0	0	0	0.004672	0	3	2									
CHCHD6	84303	broad.mit.edu	37	3	126676358	126676358	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:126676358C>T	uc003ejf.1	+	7	704	c.666C>T	c.(664-666)GTC>GTT	p.V222V	CHCHD6_uc010hsj.1_Silent_p.V223V	NM_032343	NP_115719	Q9BRQ6	CHCH6_HUMAN	coiled-coil-helix-coiled-coil-helix domain	222	CHCH.										0						CGGACCTGGTCAAGGCATACC	0.647		NaN											0	0	0	0.001168	0	6	4									
PLXND1	23129	broad.mit.edu	37	3	129293326	129293326	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:129293326G>A	uc003emx.2	-	12	2638	c.2538C>T	c.(2536-2538)GTC>GTT	p.V846V		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	846	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						CACAGTTATAGACCATGACTG	0.652		NaN											0	0	0	0.004482	0	9	21									
ACPP	55	broad.mit.edu	37	3	132071660	132071660	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:132071660G>A	uc010htp.2	+	9	1051	c.961G>A	c.(961-963)GAG>AAG	p.E321K	ACPP_uc003eon.3_Missense_Mutation_p.E288K|ACPP_uc003eop.3_Missense_Mutation_p.E321K	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	321						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						ATTGTACTTTGAGAAGGGGTA	0.433		NaN											0	0	0	0.00499	0	17	94									
DNAJC13	23317	broad.mit.edu	37	3	132169512	132169512	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:132169512C>T	uc003eor.2	+	6	423	c.358C>T	c.(358-360)CAC>TAC	p.H120Y	DNAJC13_uc010htq.1_Missense_Mutation_p.H120Y	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	120							heat shock protein binding			ovary(1)|breast(1)	2						CTATAAGCATCACTGGAGTGA	0.323		NaN											0	0	0	0.01441	0	60	41									
CEP70	80321	broad.mit.edu	37	3	138256169	138256169	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:138256169C>T	uc003esl.2	-	7	684	c.486G>A	c.(484-486)AAG>AAA	p.K162K	CEP70_uc011bmk.1_Silent_p.K142K|CEP70_uc011bml.1_Silent_p.K144K|CEP70_uc011bmm.1_Silent_p.K10K|CEP70_uc003esm.2_Silent_p.K162K|CEP70_uc003esn.2_Silent_p.K162K	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	162	Potential.				G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						TTCGTTTTTTCTTATAATGCT	0.343		NaN											0	0	0	0.010729	0	11	41									
FOXL2	668	broad.mit.edu	37	3	138665349	138665349	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:138665349C>T	uc003esw.2	-	1	634	c.216G>A	c.(214-216)GAG>GAA	p.E72E	uc003esv.1_5'Flank|C3orf72_uc003esx.1_5'Flank|C3orf72_uc011bmr.1_5'Flank	NM_023067	NP_075555	P58012	FOXL2_HUMAN	forkhead box L2	72	Fork-head.				convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			ovary(266)|large_intestine(1)|skin(1)	268						TGAGCCTCTTCTCCGCGCTCT	0.632		NaN	Mis		granulosa-cell tumour of the ovary		Blepharophimosis|ptosis and epicanthus inversus Types I|II; Premature ovarian failure type III						0	0	0	0.012319	0	21	27									
RBP1	5947	broad.mit.edu	37	3	139258348	139258348	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:139258348C>T	uc003eti.2	-	1	324	c.213G>A	c.(211-213)TGG>TGA	p.W71*	RBP1_uc011bmx.1_Nonsense_Mutation_p.W71*|RBP1_uc010huj.2_RNA|RBP1_uc011bmy.1_Nonsense_Mutation_p.W71*	NM_002899	NP_002890	P09455	RET1_HUMAN	retinol binding protein 1, cellular isoform a	9						cytoplasm	retinal binding|retinol binding|transporter activity				0					Vitamin A(DB00162)	CCAACATCTTCCAGTACCCAG	0.682		NaN											0	0	0	0.001984	0	6	10									
ACPL2	92370	broad.mit.edu	37	3	141006166	141006166	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:141006166C>T	uc003etu.2	+	7	675	c.376C>T	c.(376-378)CAC>TAC	p.H126Y	ACPL2_uc003etv.2_Missense_Mutation_p.H126Y|ACPL2_uc011bna.1_Missense_Mutation_p.H88Y|ACPL2_uc011bnb.1_Missense_Mutation_p.H109Y	NM_152282	NP_689495	Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2 precursor	126						extracellular region	acid phosphatase activity			skin(1)	1						GAAACCGTATCACCCAAAACT	0.463		NaN											0	0	0	0.004289	0	36	119									
GRK7	131890	broad.mit.edu	37	3	141526645	141526645	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:141526645G>A	uc011bnd.1	+	3	1293	c.1209G>A	c.(1207-1209)CTG>CTA	p.L403L		NM_139209	NP_631948	Q8WTQ7	GRK7_HUMAN	G-protein-coupled receptor kinase 7 precursor	403	Protein kinase.				visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						AAGAGGATCTGAAGCAAAGAA	0.433		NaN											0	0	0	0.008291	0	10	80									
ATP1B3	483	broad.mit.edu	37	3	141626055	141626055	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:141626055C>T	uc003eug.1	+	3	459	c.285C>T	c.(283-285)TTC>TTT	p.F95F	ATP1B3_uc011bne.1_RNA|ATP1B3_uc003euh.1_Silent_p.F81F	NM_001679	NP_001670	P54709	AT1B3_HUMAN	Na+/K+ -ATPase beta 3 subunit	95	Extracellular (Potential).				ATP biosynthetic process|blood coagulation|leukocyte migration	melanosome|sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity				0						AATATACATTCAGTAGGTCTG	0.363		NaN											0	0	0	0.00632	0	28	84									
TRPC1	7220	broad.mit.edu	37	3	142509894	142509894	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:142509894A>G	uc003evc.2	+	8	1467	c.1331A>G	c.(1330-1332)TAT>TGT	p.Y444C	TRPC1_uc003evb.2_Missense_Mutation_p.Y410C|TRPC1_uc011bni.1_Missense_Mutation_p.Y11C	NM_003304	NP_003295	P48995	TRPC1_HUMAN	transient receptor potential cation channel,	444	Cytoplasmic (Potential).				axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						AGACTCTGGTATGAAGGGTTG	0.328		NaN											0	0	0	0.008871	0	18	68									
PLSCR5	389158	broad.mit.edu	37	3	146311816	146311816	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:146311816G>C	uc003ewb.2	-	4	1348	c.344C>G	c.(343-345)ACT>AGT	p.T115S	PLSCR5_uc010hvb.2_Missense_Mutation_p.T103S|PLSCR5_uc010hvc.2_Missense_Mutation_p.T115S	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	115											0						AGATCGCAGAGTGGAACAGAA	0.458		NaN											0	0	0	0.00623	0	40	135									
RNF13	11342	broad.mit.edu	37	3	149678727	149678727	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:149678727G>A	uc003exn.3	+	11	1766	c.982G>A	c.(982-984)GAA>AAA	p.E328K	RNF13_uc003exp.3_Missense_Mutation_p.E328K|RNF13_uc010hvh.2_Missense_Mutation_p.E209K	NM_007282	NP_009213	O43567	RNF13_HUMAN	ring finger protein 13	328	Cytoplasmic (Potential).				protein autoubiquitination	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane|nuclear inner membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		all_neural(597;0.0138)|Myeloproliferative disorder(1037;0.0255)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGCTTTATCGGAATCCCGCTC	0.413		NaN											0	0	0	0.012319	0	23	59									
RAP2B	5912	broad.mit.edu	37	3	152880887	152880887	+	Silent	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:152880887T>C	uc003ezr.2	+	1	859	c.405T>C	c.(403-405)GCT>GCC	p.A135A		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	135					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			AGGCCCTGGCTGAGGAGTGGA	0.632		NaN											0	0	0	0.003163	0	13	20									
MME	4311	broad.mit.edu	37	3	154886393	154886393	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:154886393G>A	uc010hvr.1	+	19	2104	c.1893G>A	c.(1891-1893)TGG>TGA	p.W631*	MME_uc003fab.1_Nonsense_Mutation_p.W631*|MME_uc003fac.1_Nonsense_Mutation_p.W631*|MME_uc003fad.1_Nonsense_Mutation_p.W631*|MME_uc003fae.1_Nonsense_Mutation_p.W631*	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	631	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	ACTTTTCCTGGGACCTGGCAG	0.408		NaN											0	0	0	0.00632	0	28	107									
SLC33A1	9197	broad.mit.edu	37	3	155571662	155571662	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:155571662G>A	uc003fan.3	-	1	506	c.125C>T	c.(124-126)TCA>TTA	p.S42L	SLC33A1_uc003fao.1_Missense_Mutation_p.S42L	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	42	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCGGCCCGCTGAGTCCAAATG	0.602		NaN											0	0	0	0.013537	0	11	47									
ARL14	80117	broad.mit.edu	37	3	160395402	160395402	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:160395402G>A	uc003fdq.2	+	1	455	c.268G>A	c.(268-270)GAC>AAC	p.D90N		NM_025047	NP_079323	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	90					small GTPase mediated signal transduction	intracellular	GTP binding				0			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			GTATGTTGTGGACAGTACAGA	0.433		NaN											0	0	0	0.001855	0	12	82									
BCHE	590	broad.mit.edu	37	3	165548500	165548500	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:165548500C>G	uc003fem.3	-	2	482	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	108					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	TTCCACATCTCTGATCCATGG	0.393		NaN											0	0	0	0.01441	0	64	41									
ZBBX	79740	broad.mit.edu	37	3	167045793	167045793	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:167045793T>A	uc003fep.2	-	11	1122	c.799A>T	c.(799-801)AGT>TGT	p.S267C	ZBBX_uc011bpc.1_Missense_Mutation_p.S267C|ZBBX_uc003feq.2_Missense_Mutation_p.S238C	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	267						intracellular	zinc ion binding			ovary(2)	2						CTCCATTGACTTAACACTTCC	0.348		NaN											0	0	0	0.01441	0	49	178									
SLC2A2	6514	broad.mit.edu	37	3	170725017	170725017	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:170725017C>T	uc003fhe.1	-	5	841	c.532G>A	c.(532-534)GAA>AAA	p.E178K	SLC2A2_uc003fhf.1_Missense_Mutation_p.E5K|SLC2A2_uc011bpu.1_Missense_Mutation_p.E51K	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	178	Helical; Name=4; (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GGAGCAATTTCACCGATATAC	0.428		NaN											0	0	0	0.008361	0	30	28									
TNIK	23043	broad.mit.edu	37	3	170786662	170786662	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:170786662G>A	uc003fhh.2	-	30	4019	c.3674C>T	c.(3673-3675)TCT>TTT	p.S1225F	TNIK_uc003fhi.2_Missense_Mutation_p.S1170F|TNIK_uc003fhj.2_Missense_Mutation_p.S1196F|TNIK_uc003fhk.2_Missense_Mutation_p.S1217F|TNIK_uc003fhl.2_Missense_Mutation_p.S1141F|TNIK_uc003fhm.2_Missense_Mutation_p.S1162F|TNIK_uc003fhn.2_Missense_Mutation_p.S1188F|TNIK_uc003fho.2_Missense_Mutation_p.S1133F|TNIK_uc003fhg.2_Missense_Mutation_p.S403F|TNIK_uc003fhp.2_Missense_Mutation_p.S157F	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	1225	CNH.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GATATCATAAGAGTTTCCTGA	0.378		NaN											0	0	0	0.006214	0	10	49									
PLD1	5337	broad.mit.edu	37	3	171338225	171338225	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:171338225G>C	uc003fhs.2	-	24	2795	c.2679C>G	c.(2677-2679)ATC>ATG	p.I893M	PLD1_uc003fht.2_Missense_Mutation_p.I855M|PLD1_uc003fhu.3_Missense_Mutation_p.I187M	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	893	Catalytic.|PLD phosphodiesterase 2.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TGTGGACATAGATAAGCTCAG	0.353		NaN											0	0	0	0.006122	0	16	116									
FNDC3B	64778	broad.mit.edu	37	3	172061911	172061911	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:172061911G>A	uc003fhy.2	+	19	2285	c.2113G>A	c.(2113-2115)GAG>AAG	p.E705K	FNDC3B_uc003fhz.3_Missense_Mutation_p.E705K	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	705	Fibronectin type-III 5.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TGAGGTCTCAGAGTACAGCGT	0.527		NaN											0	0	0	0.00245	0	12	111									
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.007291	0	29	37									
MFN1	55669	broad.mit.edu	37	3	179066706	179066706	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:179066706G>A	uc003fjs.2	+	2	193	c.67G>A	c.(67-69)GAC>AAC	p.D23N	MFN1_uc010hxb.2_RNA|MFN1_uc003fjt.2_Missense_Mutation_p.D51N	NM_033540	NP_284941	Q8IWA4	MFN1_HUMAN	mitofusin 1	23	Cytoplasmic (Potential).				mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			ovary(2)|large_intestine(1)	3	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TGCAATCTTTGACCAGTTACT	0.358		NaN											0	0	0	0.006999	0	38	163									
LAMP3	27074	broad.mit.edu	37	3	182872117	182872117	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:182872117G>A	uc003flh.3	-	2	336	c.112C>T	c.(112-114)CAA>TAA	p.Q38*		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	38	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			GCAGTAGGTTGAGAATAATCT	0.398		NaN											0	0	0	0.01441	0	57	70									
ECE2	9718	broad.mit.edu	37	3	183967552	183967552	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:183967552G>A	uc003fni.3	+	1	108	c.70G>A	c.(70-72)GAG>AAG	p.E24K	ALG3_uc003fne.2_5'Flank|ALG3_uc011brc.1_5'Flank|ALG3_uc011brd.1_5'Flank|ALG3_uc011bre.1_5'Flank|ALG3_uc003fnf.1_5'Flank|ALG3_uc011brf.1_5'Flank|ECE2_uc003fnh.3_Missense_Mutation_p.E24K	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	24	Cytoplasmic (Potential).|Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCGCGAAGTCGAGTACTGGGA	0.672		NaN									OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	10	19									
TRA2B	6434	broad.mit.edu	37	3	185643391	185643391	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:185643391C>T	uc003fpv.2	-	3	470	c.194G>A	c.(193-195)CGA>CAA	p.R65Q	TRA2B_uc003fpt.2_5'Flank|TRA2B_uc003fpu.2_RNA|TRA2B_uc010hym.2_5'UTR|TRA2B_uc003fpw.2_Missense_Mutation_p.R65Q	NM_004593	NP_004584	P62995	TRA2B_HUMAN	splicing factor, arginine/serine-rich 10	65	Arg/Ser-rich (RS1 domain).				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			ovary(2)	2						ATAATGCCTTCGGGAGCTTCT	0.463		NaN											0	0	0	0.003163	0	16	47									
FETUB	26998	broad.mit.edu	37	3	186358310	186358310	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:186358310C>T	uc010hyq.2	+	2	322	c.61C>T	c.(61-63)CCA>TCA	p.P21S	FETUB_uc011brz.1_Intron|FETUB_uc003fqn.2_Missense_Mutation_p.P21S|FETUB_uc003fqo.2_5'UTR|FETUB_uc010hyr.2_Missense_Mutation_p.P21S|FETUB_uc010hys.2_5'UTR|FETUB_uc003fqp.3_Missense_Mutation_p.P21S	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	21						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		AGCAATGTCTCCACCCCAGCT	0.592		NaN											0	0	0	0.01441	0	101	101									
MASP1	5648	broad.mit.edu	37	3	186969425	186969425	+	Silent	SNP	C	C	T	rs116595107	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:186969425C>T	uc003frh.1	-	7	1340	c.1008G>A	c.(1006-1008)CTG>CTA	p.L336L	MASP1_uc003fri.2_Silent_p.L336L|MASP1_uc003frj.2_Silent_p.L305L|MASP1_uc003frk.1_Silent_p.L336L|MASP1_uc011bse.1_Silent_p.L310L	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	336	Sushi 1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TCTGCACCTTCAGCACTTTGT	0.552		NaN											0	0	0	0.01441	0	60	50									
TP63	8626	broad.mit.edu	37	3	189349350	189349350	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:189349350G>A	uc003fry.2	+	1	135	c.46G>A	c.(46-48)GAC>AAC	p.D16N	TP63_uc003frx.2_Missense_Mutation_p.D16N|TP63_uc003frz.2_Missense_Mutation_p.D16N|TP63_uc010hzc.1_Missense_Mutation_p.D16N	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	16	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		GTACTGCCCTGACCCTTACAT	0.378		NaN							Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.007835	0	40	125									
HES1	3280	broad.mit.edu	37	3	193854434	193854434	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:193854434G>A	uc003ftq.1	+	2	373	c.137G>A	c.(136-138)CGA>CAA	p.R46Q	HES1_uc011bst.1_Missense_Mutation_p.R46Q	NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	46	Basic motif.				endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		GAGAAAAGACGAAGAGCAAGA	0.408		NaN											0	0	0	0.008291	0	10	14									
HES1	3280	broad.mit.edu	37	3	193855629	193855629	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:193855629C>T	uc003ftq.1	+	4	686	c.450C>T	c.(448-450)ATC>ATT	p.I150I		NM_005524	NP_005515	Q14469	HES1_HUMAN	hairy and enhancer of split 1	150					endocrine pancreas development|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway	nucleus	histone deacetylase binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)	2	all_cancers(143;7.3e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;3.65e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;1.48e-05)		TGACCCAGATCAATGCCATGA	0.716		NaN											0	0	0	0.001168	0	5	18									
RNF168	165918	broad.mit.edu	37	3	196214289	196214289	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:196214289C>G	uc003fwq.2	-	3	1077	c.539G>C	c.(538-540)AGA>ACA	p.R180T	RNF168_uc010iah.2_Missense_Mutation_p.R13T	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	180	MIU motif 1.				double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		GCTTAGCTTTCTTGCCAGTTC	0.473		NaN											0	0	0	0.01441	0	90	290									
BDH1	622	broad.mit.edu	37	3	197238892	197238892	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:197238892G>A	uc003fxr.2	-	8	1308	c.906C>T	c.(904-906)GTC>GTT	p.V302V	BDH1_uc003fxs.2_Silent_p.V302V|BDH1_uc003fxt.2_Silent_p.V215V|BDH1_uc003fxu.2_Silent_p.V302V	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	302					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	GGGCGTGTGTGACAGCATCGA	0.572		NaN											0	0	0	0.003954	0	24	72									
MFSD7	84179	broad.mit.edu	37	4	676629	676629	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:676629C>T	uc003gay.2	-	9	1262	c.1205G>A	c.(1204-1206)CGA>CAA	p.R402Q	MFSD7_uc003gaw.2_Missense_Mutation_p.R144Q|MFSD7_uc003gax.2_Missense_Mutation_p.R401Q|MFSD7_uc003gaz.2_Missense_Mutation_p.R283Q|MFSD7_uc003gba.2_Missense_Mutation_p.R305Q|MFSD7_uc003gbb.1_Missense_Mutation_p.R337Q	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	402					transmembrane transport	integral to membrane					0						CTCCGAGCGTCGCACAGTCAG	0.652		NaN											0	0	0	0.009096	0	4	6									
MFSD7	84179	broad.mit.edu	37	4	678583	678583	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:678583C>A	uc003gay.2	-	5	705	c.648G>T	c.(646-648)GAG>GAT	p.E216D	MFSD7_uc003gaw.2_5'UTR|MFSD7_uc003gax.2_Missense_Mutation_p.E216D|MFSD7_uc003gaz.2_Missense_Mutation_p.E97D|MFSD7_uc003gba.2_Missense_Mutation_p.E119D|MFSD7_uc003gbb.1_Missense_Mutation_p.E152D	NM_032219	NP_115595	Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing	216					transmembrane transport	integral to membrane					0						GGGGCACACTCTCCCACAGGC	0.657		NaN											1	0	4.96729e-08	0.008871	5.12554e-08	17	9									
GAK	2580	broad.mit.edu	37	4	887189	887189	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:887189C>T	uc003gbm.3	-	9	1165	c.966G>A	c.(964-966)GTG>GTA	p.V322V	GAK_uc003gbn.3_Silent_p.V243V|GAK_uc010ibk.1_Silent_p.V216V|GAK_uc003gbl.3_Silent_p.V186V	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	322					cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		ACTTGGGGTTCACGTTGCGGG	0.662		NaN											0	0	0	0.010729	0	9	17									
CRIPAK	285464	broad.mit.edu	37	4	1388306	1388306	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:1388306G>A	uc003gdf.2	+	1	2967	c.7G>A	c.(7-9)GAG>AAG	p.E3K		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	3					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			tcttatGCATGAGCCCTCGCT	0.338		NaN											0	0	0	0.01441	0	81	59									
TACC3	10460	broad.mit.edu	37	4	1746259	1746259	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:1746259G>A	uc003gdo.2	+	14	2346	c.2238G>A	c.(2236-2238)CTG>CTA	p.L746L	TACC3_uc003gdp.2_Silent_p.L386L|TACC3_uc010ica.2_Silent_p.L167L	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	746	Potential.					centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AAGAGTCACTGAAGAAGTGCG	0.607		NaN											0	0	0	0.006214	0	9	55									
TNIP2	79155	broad.mit.edu	37	4	2746669	2746669	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:2746669C>T	uc003gfg.2	-	4	748	c.661G>A	c.(661-663)GAA>AAA	p.E221K	TNIP2_uc003gff.2_Missense_Mutation_p.E114K|TNIP2_uc003gfh.2_Intron	NM_024309	NP_077285	Q8NFZ5	TNIP2_HUMAN	A20-binding inhibitor of NF-kappaB activation 2	221	Potential.					cytosol	protein binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTGAGGTCTTCAACCTGAAGA	0.582		NaN											0	0	0	0.004482	0	8	35									
RGS12	6002	broad.mit.edu	37	4	3344756	3344756	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:3344756C>T	uc003ggw.2	+	3	2878	c.1974C>T	c.(1972-1974)ATC>ATT	p.I658I	RGS12_uc003ggu.2_Silent_p.I658I|RGS12_uc010ics.1_5'UTR|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Silent_p.I658I|RGS12_uc003ggy.1_Silent_p.I56I|RGS12_uc003ggx.1_Silent_p.I658I	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	658						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GATTCAGTATCACTCGCTCCC	0.433		NaN											0	0	0	0.004007	0	16	65									
RGS12	6002	broad.mit.edu	37	4	3424704	3424704	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:3424704C>T	uc003ggw.2	+	12	4010	c.3106C>T	c.(3106-3108)CGG>TGG	p.R1036W	RGS12_uc003ggv.2_Missense_Mutation_p.R1036W|RGS12_uc003ggy.1_Missense_Mutation_p.R434W|RGS12_uc003ggz.2_Missense_Mutation_p.R388W|RGS12_uc010icu.1_Missense_Mutation_p.R235W|RGS12_uc011bvs.1_Missense_Mutation_p.R378W|RGS12_uc003gha.2_Missense_Mutation_p.R378W|RGS12_uc010icv.2_Missense_Mutation_p.R235W|RGS12_uc003ghb.2_Missense_Mutation_p.R235W	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1036	RBD 2.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CACCTTGTTTCGGTAAGAGGA	0.582		NaN											0	0	0	0.00308	0	7	35									
ZBTB49	166793	broad.mit.edu	37	4	4303908	4303908	+	Silent	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:4303908A>T	uc003ghu.2	+	3	520	c.345A>T	c.(343-345)ACA>ACT	p.T115T	ZBTB49_uc003ghv.2_Intron|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_5'Flank	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						TGTGTCACACATTTTTAAAAT	0.418		NaN											0	0	0	0.013114	0	47	143									
EVC2	132884	broad.mit.edu	37	4	5567045	5567045	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:5567045C>G	uc003gij.2	-	21	3653	c.3599G>C	c.(3598-3600)CGA>CCA	p.R1200P	EVC2_uc011bwb.1_Missense_Mutation_p.R640P|EVC2_uc003gik.2_Missense_Mutation_p.R1120P	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1200						integral to membrane				large_intestine(3)|ovary(2)	5						CAGATCTCCTCGCAGTTTGCC	0.493		NaN											0	0	0	0.004482	0	7	107									
EVC2	132884	broad.mit.edu	37	4	5578040	5578040	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:5578040C>T	uc003gij.2	-	18	3253	c.3199G>A	c.(3199-3201)GAA>AAA	p.E1067K	EVC2_uc011bwb.1_Missense_Mutation_p.E507K|EVC2_uc003gik.2_Missense_Mutation_p.E987K	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	1067	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						ACCTGCCTTTCAGAATCCACC	0.617		NaN											0	0	0	0.010818	0	30	100									
CRMP1	1400	broad.mit.edu	37	4	5838496	5838496	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:5838496G>A	uc003gip.2	-	11	1207	c.1106C>T	c.(1105-1107)GCG>GTG	p.A369V	CRMP1_uc003gin.1_Missense_Mutation_p.A281V|CRMP1_uc003giq.2_Missense_Mutation_p.A369V|CRMP1_uc003gir.2_Missense_Mutation_p.A364V|CRMP1_uc003gis.2_Missense_Mutation_p.A483V	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	369				Missing (in Ref. 6; AAK55500).	axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CCTTACCACCGCCTTGTCCCA	0.547		NaN											0	0	0	0.012213	0	29	65									
CCDC96	257236	broad.mit.edu	37	4	7044015	7044015	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:7044015C>T	uc003gjv.2	-	1	714	c.651G>A	c.(649-651)CAG>CAA	p.Q217Q	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	217											0						CCTGCAGCTTCTGGACCTCCT	0.582		NaN											0	0	0	0.004289	0	36	22									
CCDC96	257236	broad.mit.edu	37	4	7044026	7044026	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:7044026C>T	uc003gjv.2	-	1	703	c.640G>A	c.(640-642)GAG>AAG	p.E214K	TADA2B_uc003gjw.3_5'Flank|TADA2B_uc010idi.2_5'Flank	NM_153376	NP_699207	Q2M329	CCD96_HUMAN	coiled-coil domain containing 96	214	Glu-rich.										0						TGGACCTCCTCGGACCACTCG	0.552		NaN											0	0	0	0.009535	0	30	21									
SH3TC1	54436	broad.mit.edu	37	4	8237168	8237168	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:8237168G>A	uc003gkv.3	+	15	3392	c.3291G>A	c.(3289-3291)CAG>CAA	p.Q1097Q	SH3TC1_uc003gkw.3_Silent_p.Q1021Q|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_RNA	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	1097							binding			large_intestine(2)|pancreas(1)	3						AGGTGGCACAGAACGTGGCCC	0.647		NaN											0	0	0	0.013726	0	34	32									
GPR125	166647	broad.mit.edu	37	4	22456499	22456499	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:22456499G>A	uc003gqm.1	-	4	728	c.463C>T	c.(463-465)CTG>TTG	p.L155L	GPR125_uc010ieo.1_Silent_p.L29L|GPR125_uc003gqo.2_Silent_p.L155L	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	155	Extracellular (Potential).|LRR 4.				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				AGCCGAACCAGATTGGTGAGT	0.358		NaN											0	0	0	0.004482	0	9	60									
LGI2	55203	broad.mit.edu	37	4	25005688	25005688	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:25005688G>C	uc003grf.2	-	8	1122	c.1023C>G	c.(1021-1023)GTC>GTG	p.V341V		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	341	EAR 3.					extracellular region					0		Breast(46;0.173)				TGTCTGCGATGACAAAGAACG	0.468		NaN											0	0	0	0.01441	0	70	54									
LGI2	55203	broad.mit.edu	37	4	25005740	25005740	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:25005740G>A	uc003grf.2	-	8	1070	c.971C>T	c.(970-972)TCC>TTC	p.S324F		NM_018176	NP_060646	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	324	EAR 3.					extracellular region					0		Breast(46;0.173)				ATTGGGCTTGGAAATGCGAGA	0.473		NaN											0	0	0	0.01441	0	120	78									
SLC34A2	10568	broad.mit.edu	37	4	25664407	25664407	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:25664407G>A	uc003grr.2	+	3	274	c.193G>A	c.(193-195)GAG>AAG	p.E65K	SLC34A2_uc003grs.2_Missense_Mutation_p.E64K|SLC34A2_uc010iev.2_Missense_Mutation_p.E64K	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	65	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				TGAGCCCACTGAGGTGGATGA	0.517		NaN											0	0	0	0.01441	0	103	64									
TBC1D19	55296	broad.mit.edu	37	4	26750122	26750122	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:26750122G>A	uc003gsf.3	+	19	1679	c.1409G>A	c.(1408-1410)GGA>GAA	p.G470E	TBC1D19_uc010iew.2_Missense_Mutation_p.G470E|TBC1D19_uc011bxu.1_Missense_Mutation_p.G405E	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	470	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				AGAATCCTAGGATACAACTCT	0.383		NaN											0	0	0	0.01441	0	65	132									
WDR19	57728	broad.mit.edu	37	4	39271675	39271675	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:39271675G>C	uc003gtv.2	+	31	3592	c.3438G>C	c.(3436-3438)GAG>GAC	p.E1146D	WDR19_uc011byi.1_Missense_Mutation_p.E986D|WDR19_uc003gtw.1_Missense_Mutation_p.E743D	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1146					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TTCCCTCCGAGATGGCCACCA	0.463		NaN											0	0	0	0.006122	0	19	58									
WDR19	57728	broad.mit.edu	37	4	39278656	39278656	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:39278656G>A	uc003gtv.2	+	34	3887	c.3733G>A	c.(3733-3735)GAG>AAG	p.E1245K	WDR19_uc011byi.1_Missense_Mutation_p.E1085K	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1245					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						CGATATATCTGAGATAGAAGA	0.418		NaN											0	0	0	0.013726	0	31	94									
KLB	152831	broad.mit.edu	37	4	39448203	39448203	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:39448203C>T	uc003gua.2	+	4	1954	c.1857C>T	c.(1855-1857)GCC>GCT	p.A619A	KLB_uc011byj.1_Silent_p.A610A	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	619	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						ACCGACAGGCCCTGAGGTACT	0.597		NaN											0	0	0	0.001855	0	13	52									
PDS5A	23244	broad.mit.edu	37	4	39978093	39978093	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:39978093C>T	uc003guv.3	-	2	645	c.105G>A	c.(103-105)AAG>AAA	p.K35K	PDS5A_uc010ifo.2_5'UTR|PDS5A_uc003guw.3_Silent_p.K35K	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	35					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						CCGTGGTGATCTTGTCGGTGA	0.557		NaN									OREG0016159	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	64	84									
N4BP2	55728	broad.mit.edu	37	4	40103906	40103906	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40103906G>A	uc003guy.3	+	4	779	c.441G>A	c.(439-441)CAG>CAA	p.Q147Q	N4BP2_uc010ifq.2_Silent_p.Q67Q|N4BP2_uc010ifr.2_Silent_p.Q67Q	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	147	Potential.					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						CCTTAATACAGAATGCTTTTG	0.333		NaN											0	0	0	0.004656	0	27	87									
N4BP2	55728	broad.mit.edu	37	4	40123254	40123254	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40123254C>T	uc003guy.3	+	9	3861	c.3523C>T	c.(3523-3525)CCT>TCT	p.P1175S	N4BP2_uc010ifq.2_Missense_Mutation_p.P1095S|N4BP2_uc010ifr.2_Missense_Mutation_p.P1095S	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1175						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TTCTAATTCTCCTGTGCCAGA	0.418		NaN											0	0	0	0.003271	0	36	82									
N4BP2	55728	broad.mit.edu	37	4	40144375	40144375	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40144375G>A	uc003guy.3	+	15	5206	c.4868G>A	c.(4867-4869)AGA>AAA	p.R1623K	N4BP2_uc010ifq.2_Missense_Mutation_p.R1543K|N4BP2_uc010ifr.2_Missense_Mutation_p.R1526K	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1623						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GATGACTACAGAGCAGAGGCT	0.413		NaN											0	0	0	0.007291	0	28	91									
RHOH	399	broad.mit.edu	37	4	40245409	40245409	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40245409G>A	uc003guz.2	+	3	1127	c.403G>A	c.(403-405)GAA>AAA	p.E135K		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	135					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						CAATGCCATGGAAGGGAAGAA	0.612		NaN											0	0	0	0.004007	0	15	41									
CHRNA9	55584	broad.mit.edu	37	4	40350954	40350954	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:40350954G>A	uc003gva.1	+	4	437	c.421G>A	c.(421-423)GGG>AGG	p.G141R		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	141	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	GCGGTATGATGGGCTGATCAC	0.507		NaN											0	0	0	0.007291	0	29	117									
GABRG1	2565	broad.mit.edu	37	4	46053535	46053535	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:46053535G>A	uc003gxb.2	-	8	1189	c.1037C>T	c.(1036-1038)GCA>GTA	p.A346V		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	346	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		CATCAAGGCTGCAAAAACAAA	0.373		NaN											0	0	0	0.003163	0	16	43									
ATP10D	57205	broad.mit.edu	37	4	47565643	47565643	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:47565643C>T	uc003gxk.1	+	15	2878	c.2714C>T	c.(2713-2715)TCT>TTT	p.S905F	ATP10D_uc003gxl.1_Missense_Mutation_p.S153F	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	905	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GTCCCTGAATCTATAGAAGCT	0.473		NaN											0	0	0	0.00245	0	15	50									
ATP10D	57205	broad.mit.edu	37	4	47578955	47578955	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:47578955C>G	uc003gxk.1	+	19	3696	c.3532C>G	c.(3532-3534)CTG>GTG	p.L1178V	ATP10D_uc003gxl.1_Missense_Mutation_p.L426V	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1178	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CCTCATGCAACTGCCTGAACT	0.438		NaN											0	0	0	0.00632	0	29	119									
SLAIN2	57606	broad.mit.edu	37	4	48422195	48422195	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:48422195C>T	uc003gya.3	+	7	1558	c.1414C>T	c.(1414-1416)CGG>TGG	p.R472W		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	472						centrosome					0						TTTGGCTCTTCGGCAACCAGT	0.478		NaN											0	0	0	0.008291	0	10	39									
FRYL	285527	broad.mit.edu	37	4	48525073	48525073	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:48525073C>T	uc003gyh.1	-	54	7971	c.7366G>A	c.(7366-7368)GAC>AAC	p.D2456N	FRYL_uc003gyf.1_5'Flank|FRYL_uc003gyg.1_Missense_Mutation_p.D1152N|FRYL_uc003gyi.1_Missense_Mutation_p.D1344N|FRYL_uc003gyj.1_Missense_Mutation_p.D751N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2456					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						TCAATACTGTCCAGTGAGCGC	0.483		NaN											0	0	0	0.007835	0	40	55									
FRYL	285527	broad.mit.edu	37	4	48605373	48605373	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:48605373C>T	uc003gyh.1	-	12	1472	c.867G>A	c.(865-867)TTG>TTA	p.L289L	FRYL_uc003gyk.2_Silent_p.L289L	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						CAAAATTTTTCAAACAGGGAA	0.289		NaN											0	0	0	0.006999	0	41	63									
KIT	3815	broad.mit.edu	37	4	55524236	55524236	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:55524236C>T	uc010igr.2	+	1	142	c.55C>T	c.(55-57)CGC>TGC	p.R19C	KIT_uc010igs.2_Missense_Mutation_p.R19C	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	19					male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	CCTACTGCTTCGCGTCCAGAC	0.667		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				0	0	0	0.013537	0	11	17									
LPHN3	23284	broad.mit.edu	37	4	62813849	62813849	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:62813849C>T	uc010ihh.2	+	14	2629	c.2456C>T	c.(2455-2457)TCA>TTA	p.S819L	LPHN3_uc003hcq.3_Missense_Mutation_p.S819L|LPHN3_uc003hct.2_Missense_Mutation_p.S212L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	806	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						CCTAACTGTTCATTTTGGAGC	0.383		NaN											0	0	0	0.00308	0	7	26									
TMPRSS11A	339967	broad.mit.edu	37	4	68784859	68784859	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:68784859C>T	uc003hdr.1	-	8	914	c.793G>A	c.(793-795)GAG>AAG	p.E265K	LOC550112_uc003hdl.3_Intron|TMPRSS11A_uc003hds.1_Missense_Mutation_p.E262K	NM_182606	NP_872412	Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A isoform 1	265	Peptidase S1.|Extracellular (Potential).				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			skin(1)	1						CGGTACTTCTCATGGATAATA	0.408		NaN											0	0	0	0.01441	0	60	74									
AFM	173	broad.mit.edu	37	4	74350018	74350018	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:74350018G>A	uc003hhb.2	+	3	212	c.181G>A	c.(181-183)GAA>AAA	p.E61K		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	61	Albumin 1.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGCAACCTTTGAAGAAATGGA	0.403		NaN											0	0	0	0.00333	0	25	69									
RCHY1	25898	broad.mit.edu	37	4	76434446	76434446	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:76434446G>A	uc003hik.2	-	2	283	c.151C>T	c.(151-153)CAA>TAA	p.Q51*	RCHY1_uc003hij.2_Nonsense_Mutation_p.Q51*|RCHY1_uc003hil.2_Nonsense_Mutation_p.Q51*|RCHY1_uc010iip.2_Nonsense_Mutation_p.Q51*|RCHY1_uc010iiq.2_RNA|RCHY1_uc010iir.2_Intron	NM_015436	NP_056251	Q96PM5	ZN363_HUMAN	ring finger and CHY zinc finger domain	51	CHY-type.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nuclear speck|ubiquitin ligase complex	electron carrier activity|p53 binding|protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CGATCTAGTTGATGATCTTCA	0.348		NaN											0	0	0	0.008361	0	29	15									
PPEF2	5470	broad.mit.edu	37	4	76781894	76781894	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:76781894C>T	uc003hix.2	-	17	2545	c.2188G>A	c.(2188-2190)GAG>AAG	p.E730K	PPEF2_uc003hiy.2_RNA	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	730					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCATCGCCCTCTGGGCAGGAT	0.507		NaN											0	0	0	0.00278	0	24	48									
PPEF2	5470	broad.mit.edu	37	4	76782018	76782018	+	Missense_Mutation	SNP	C	C	T	rs148045586		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:76782018C>T	uc003hix.2	-	17	2421	c.2064G>A	c.(2062-2064)ATG>ATA	p.M688I	PPEF2_uc003hiy.2_RNA	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	688					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGTCGATATTCATGTGAGAGC	0.453		NaN											0	0	0	0.00333	0	25	84									
SDAD1	55153	broad.mit.edu	37	4	76895235	76895235	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:76895235G>A	uc003hje.3	-	7	749	c.630C>T	c.(628-630)GTC>GTT	p.V210V	SDAD1_uc003hjf.3_Silent_p.V113V|SDAD1_uc011cbr.1_Silent_p.V173V	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	210					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCACCTTGGTGACCTTAGAGA	0.418		NaN											0	0	0	0.00333	0	24	65									
SCARB2	950	broad.mit.edu	37	4	77100813	77100813	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:77100813C>T	uc003hju.1	-	4	808	c.469G>A	c.(469-471)GAG>AAG	p.E157K	SCARB2_uc011cbu.1_Intron	NM_005506	NP_005497	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	157	Lumenal (Potential).				cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity				0			Lung(101;0.196)			AACATGGCCTCGATGATCTCC	0.498		NaN									OREG0016231	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	136	113									
SHROOM3	57619	broad.mit.edu	37	4	77660886	77660886	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:77660886G>A	uc011cbx.1	+	5	2513	c.1560G>A	c.(1558-1560)CAG>CAA	p.Q520Q	SHROOM3_uc011cbz.1_Silent_p.Q344Q|SHROOM3_uc003hkf.1_Silent_p.Q395Q|SHROOM3_uc003hkg.2_Silent_p.Q298Q	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	520					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			ATGGGAACCAGAATGGATCTG	0.532		NaN											0	0	0	0.01441	0	64	48									
PRDM8	56978	broad.mit.edu	37	4	81123465	81123465	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:81123465C>T	uc010ijo.2	+	8	1688	c.849C>T	c.(847-849)CTC>CTT	p.L283L	PRDM8_uc003hmb.3_Silent_p.L283L|PRDM8_uc003hmc.3_Silent_p.L283L	NM_020226	NP_064611	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	283	Gly-rich.|Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCCAGAGCCTCAgcagcggta	0.562		NaN									OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	8									
TMEM150C	441027	broad.mit.edu	37	4	83406710	83406710	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:83406710G>A	uc003hmy.1	-	8	782	c.704C>T	c.(703-705)TCA>TTA	p.S235L	TMEM150C_uc011ccj.1_Missense_Mutation_p.S265L	NM_001080506	NP_001073975	B9EJG8	T150C_HUMAN	transmembrane protein 150C	235						integral to membrane				ovary(1)	1						CAGGCTTTCTGAGAAGCTTAG	0.493		NaN											0	0	0	0.004482	0	9	12									
WDFY3	23001	broad.mit.edu	37	4	85672802	85672802	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:85672802C>G	uc003hpd.2	-	36	6215	c.5807G>C	c.(5806-5808)GGG>GCG	p.G1936A		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	1936						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CCTGTTCATCCCTGTGTCTGC	0.443		NaN											0	0	0	0.007291	0	28	142									
PTPN13	5783	broad.mit.edu	37	4	87653921	87653921	+	Splice_Site	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:87653921T>C	uc003hpz.2	+	12	2338	c.1858_splice	c.e12+2	p.D620_splice	PTPN13_uc003hpy.2_Splice_Site_p.D620_splice|PTPN13_uc003hqa.2_Splice_Site_p.D620_splice|PTPN13_uc003hqb.2_Splice_Site_p.D620_splice	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type							cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CCCTCAAAGGTACCAAGACAT	0.358		NaN											0	0	0	0.00245	0	15	19									
BMPR1B	658	broad.mit.edu	37	4	96051059	96051059	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:96051059G>A	uc003htm.3	+	9	906	c.632G>A	c.(631-633)GGA>GAA	p.G211E	BMPR1B_uc010ilb.2_Missense_Mutation_p.G211E|BMPR1B_uc003htn.3_Missense_Mutation_p.G211E	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	211	ATP (By similarity).|Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		AAACAGATTGGAAAAGGTCGC	0.458		NaN											0	0	0	0.003163	0	14	27									
UNC5C	8633	broad.mit.edu	37	4	96199421	96199421	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:96199421G>A	uc003htp.1	-	4	737	c.583C>T	c.(583-585)CCA>TCA	p.P195S	UNC5C_uc010ilc.1_Missense_Mutation_p.P195S|UNC5C_uc003htq.2_Missense_Mutation_p.P195S	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	195	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TCAGCCACTGGGATCCCTTCA	0.453		NaN											0	0	0	0.00245	0	14	52									
DAPP1	27071	broad.mit.edu	37	4	100756843	100756843	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:100756843C>T	uc003hvf.3	+	2	255	c.165C>T	c.(163-165)GAC>GAT	p.D55D	DAPP1_uc011cek.1_Silent_p.D55D|DAPP1_uc010ilh.2_Silent_p.D55D	NM_014395	NP_055210	Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and	55	SH2.				signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity				0				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		ATGGATGTGACGGCAGCTACC	0.547		NaN											0	0	0	0.013114	0	48	65									
UBE2D3	7323	broad.mit.edu	37	4	103723730	103723730	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:103723730G>C	uc003hwk.2	-	5	647	c.186C>G	c.(184-186)TTC>TTG	p.F62L	UBE2D3_uc003hwi.2_Missense_Mutation_p.F62L|UBE2D3_uc003hwj.2_RNA|UBE2D3_uc003hwl.2_Missense_Mutation_p.F62L|UBE2D3_uc011cet.1_Missense_Mutation_p.F62L|UBE2D3_uc011ceu.1_Missense_Mutation_p.F62L|UBE2D3_uc003hwo.2_Missense_Mutation_p.F62L|UBE2D3_uc003hwp.2_Missense_Mutation_p.F62L|UBE2D3_uc003hwq.2_Missense_Mutation_p.F64L|UBE2D3_uc003hwr.2_Missense_Mutation_p.F62L	NM_181887	NP_871616	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3 isoform 1	62					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		TAGGTGGTTTGAAGGGGTAGT	0.343		NaN											0	0	0	0.01441	0	50	70									
TBCK	93627	broad.mit.edu	37	4	107154786	107154786	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:107154786C>T	uc010ilv.2	-	16	1836	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	TBCK_uc003hyb.2_Missense_Mutation_p.D234N|TBCK_uc003hye.2_Missense_Mutation_p.D452N|TBCK_uc003hyc.2_Missense_Mutation_p.D428N|TBCK_uc003hyd.2_Missense_Mutation_p.D319N|TBCK_uc003hyf.2_Missense_Mutation_p.D491N	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	491	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						TCAATTGCATCGTACTTGGCA	0.269		NaN											0	0	0	0.008871	0	17	21									
DKK2	27123	broad.mit.edu	37	4	107956627	107956627	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:107956627G>A	uc003hyi.2	-	1	827	c.122C>T	c.(121-123)TCT>TTT	p.S41F	DKK2_uc010ilw.1_Intron|DKK2_uc003hyj.1_Missense_Mutation_p.S41F	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	41					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CCCGCCCAGAGAGGACTTGAT	0.612		NaN											0	0	0	0.01441	0	41	18									
SEC24B	10427	broad.mit.edu	37	4	110384687	110384687	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:110384687C>T	uc003hzk.2	+	2	819	c.764C>T	c.(763-765)TCA>TTA	p.S255L	SEC24B_uc003hzl.2_Missense_Mutation_p.S255L|SEC24B_uc011cfp.1_Missense_Mutation_p.S286L|SEC24B_uc011cfq.1_Missense_Mutation_p.S255L|SEC24B_uc011cfr.1_Missense_Mutation_p.S255L	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	255					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CAAAGTCTTTCAGGATACAGT	0.473		NaN											0	0	0	0.01441	0	76	13									
SEC24B	10427	broad.mit.edu	37	4	110460768	110460768	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:110460768G>C	uc003hzk.2	+	24	3799	c.3744G>C	c.(3742-3744)CGG>CGC	p.R1248R	SEC24B_uc003hzl.2_Silent_p.R1213R|SEC24B_uc011cfp.1_Silent_p.R1278R|SEC24B_uc011cfq.1_Silent_p.R1247R|SEC24B_uc011cfr.1_Silent_p.R1212R	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	1248					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TTGAAGACCGGACAGAGGCTG	0.328		NaN											0	0	0	0.010771	0	44	24									
CFI	3426	broad.mit.edu	37	4	110682771	110682771	+	Missense_Mutation	SNP	C	C	T	rs143366614		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:110682771C>T	uc003hzr.3	-	4	768	c.560G>A	c.(559-561)CGA>CAA	p.R187Q	CFI_uc003hzq.2_5'UTR|CFI_uc011cft.1_Missense_Mutation_p.R187Q|CFI_uc003hzs.3_Missense_Mutation_p.R187Q	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	187	SRCR.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CTCTAATCCTCGGCAATGCAC	0.388		NaN											0	0	0	0.01441	0	111	23									
ANK2	287	broad.mit.edu	37	4	114232546	114232546	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:114232546G>A	uc003ibe.3	+	24	2784	c.2684G>A	c.(2683-2685)CGA>CAA	p.R895Q	ANK2_uc003ibd.3_Missense_Mutation_p.R874Q|ANK2_uc003ibf.3_Missense_Mutation_p.R895Q|ANK2_uc011cgc.1_Missense_Mutation_p.R104Q|ANK2_uc003ibc.2_Missense_Mutation_p.R871Q|ANK2_uc011cgb.1_Missense_Mutation_p.R910Q	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	895					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGGGAGGACGATCTGACAGG	0.388		NaN											0	0	0	0.006214	0	9	37									
PDE5A	8654	broad.mit.edu	37	4	120549792	120549792	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:120549792C>T	uc003idh.2	-	1	190	c.35G>A	c.(34-36)CGA>CAA	p.R12Q	PDE5A_uc003idf.2_5'Flank|PDE5A_uc003idg.2_5'Flank|uc003idj.1_5'UTR	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	12	Poly-Gln.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	ctgctgctgtcgctgctgcCC	0.483		NaN									OREG0016307	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	24	9									
NAA15	80155	broad.mit.edu	37	4	140291390	140291390	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:140291390G>C	uc003ihu.1	+	15	2035	c.1779G>C	c.(1777-1779)AAG>AAC	p.K593N		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	593					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						AAGAGCTAAAGAAGCTACGTA	0.219		NaN											0	0	0	0.010504	0	18	2									
ZNF330	27309	broad.mit.edu	37	4	142155060	142155060	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:142155060G>A	uc003iiq.3	+	10	1100	c.880G>A	c.(880-882)GAG>AAG	p.E294K	ZNF330_uc011chl.1_Missense_Mutation_p.E234K	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	294						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					TTCAGATACTGAGTCATCAGA	0.313		NaN											0	0	0	0.010504	0	20	43									
USP38	84640	broad.mit.edu	37	4	144109040	144109040	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:144109040G>C	uc003ijb.2	+	2	1278	c.744G>C	c.(742-744)ATG>ATC	p.M248I	USP38_uc003ija.3_Missense_Mutation_p.M248I|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	248					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					CTCTTCAGATGATTACAGTTC	0.398		NaN											0	0	0	0.006122	0	19	45									
HHIP	64399	broad.mit.edu	37	4	145567932	145567932	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:145567932G>T	uc003ijs.1	+	1	760	c.105G>T	c.(103-105)AGG>AGT	p.R35S	uc003ijq.1_5'Flank|HHIP_uc003ijr.1_Missense_Mutation_p.R35S	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	35	Arg-rich.					cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GCGGAGCAAGGAGGAGAAGGT	0.562		NaN											1	0	2.4624e-09	0.008871	2.55543e-09	21	64									
OTUD4	54726	broad.mit.edu	37	4	146067481	146067481	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:146067481C>T	uc003ika.3	-	14	1303	c.1165G>A	c.(1165-1167)GAA>AAA	p.E389K	OTUD4_uc003ijz.3_Missense_Mutation_p.E388K	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	453							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CGGGATTCTTCTATAGCTTGC	0.408		NaN											0	0	0	0.01441	0	67	57									
FBXW7	55294	broad.mit.edu	37	4	153247165	153247165	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:153247165G>A	uc003ims.2	-	10	1786	c.1637C>T	c.(1636-1638)TCA>TTA	p.S546L	FBXW7_uc011cii.1_Missense_Mutation_p.S546L|FBXW7_uc003imt.2_Missense_Mutation_p.S546L|FBXW7_uc011cih.1_Missense_Mutation_p.S370L|FBXW7_uc003imq.2_Missense_Mutation_p.S466L|FBXW7_uc003imr.2_Missense_Mutation_p.S428L	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	546	WD 5.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TACCTGTAATGAATAGACTCT	0.398		NaN	Mis|N|D|F		colorectal|endometrial|T-ALL								0	0	0	0.01441	0	86	27									
KIAA0922	23240	broad.mit.edu	37	4	154525365	154525365	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:154525365C>T	uc003inm.3	+	25	3250	c.3198C>T	c.(3196-3198)TTC>TTT	p.F1066F	KIAA0922_uc010ipp.2_Silent_p.F1067F|KIAA0922_uc010ipq.2_Silent_p.F835F	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1066	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CAATTGTTTTCAGTAATCCTT	0.358		NaN											0	0	0	0.00278	0	25	54									
KIAA0922	23240	broad.mit.edu	37	4	154542885	154542885	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:154542885C>G	uc003inm.3	+	28	3792	c.3740C>G	c.(3739-3741)TCT>TGT	p.S1247C	KIAA0922_uc010ipp.2_Missense_Mutation_p.S1248C|KIAA0922_uc010ipq.2_Missense_Mutation_p.S1016C	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1247	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				TTTGAGAGGTCTGAGCTGAGC	0.428		NaN											0	0	0	0.012319	0	21	40									
NAF1	92345	broad.mit.edu	37	4	164087539	164087539	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:164087539G>A	uc003iqj.2	-	1	535	c.341C>T	c.(340-342)TCG>TTG	p.S114L	NAF1_uc010iqw.1_Missense_Mutation_p.S114L|NAF1_uc003iqk.2_RNA	NM_138386	NP_612395	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 homolog isoform a	114	Ser-rich.				rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			ovary(2)	2	all_hematologic(180;0.166)	Prostate(90;0.109)				ATCCGAGTCCGAGGTCTCCAA	0.706		NaN											0	0	0	0.013537	0	12	10									
DDX60L	91351	broad.mit.edu	37	4	169351708	169351708	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:169351708G>A	uc003irq.3	-	13	1819	c.1598C>T	c.(1597-1599)TCA>TTA	p.S533L	DDX60L_uc003irr.1_Missense_Mutation_p.S533L|DDX60L_uc003irs.1_Missense_Mutation_p.S260L	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	533							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CGTAGAGATTGATTCTAACGA	0.373		NaN											0	0	0	0.000602	0	5	14									
SLC9A3	6550	broad.mit.edu	37	5	475147	475147	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:475147C>T	uc003jbe.2	-	16	2464	c.2352G>A	c.(2350-2352)TCG>TCA	p.S784S	SLC9A3_uc011clx.1_Silent_p.S775S|LOC25845_uc003jbd.2_5'Flank|LOC25845_uc010itb.1_5'Flank	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	784	Cytoplasmic (Potential).					cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GGGCCCTCTGCGAGGGGACCA	0.672		NaN											0	0	0	0.00308	0	7	11									
SLC12A7	10723	broad.mit.edu	37	5	1081816	1081816	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:1081816C>T	uc003jbu.2	-	9	1239	c.1173G>A	c.(1171-1173)GAG>GAA	p.E391E		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	391					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CACCTTTCTTCTCCACAAACG	0.652		NaN											0	0	0	0.008291	0	10	35									
SLC12A7	10723	broad.mit.edu	37	5	1081819	1081819	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:1081819C>T	uc003jbu.2	-	9	1236	c.1170G>A	c.(1168-1170)GTG>GTA	p.V390V		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	390					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CTTTCTTCTCCACAAACGCCC	0.652		NaN											0	0	0	0.006214	0	9	35									
SLC6A18	348932	broad.mit.edu	37	5	1239598	1239598	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:1239598G>A	uc003jby.1	+	6	889	c.766G>A	c.(766-768)GAC>AAC	p.D256N		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	256	Helical; Name=6; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGTGTGGCTGGACGCAGCCAC	0.577		NaN											0	0	0	0.01441	0	60	62									
SLC6A3	6531	broad.mit.edu	37	5	1420746	1420746	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:1420746C>T	uc003jck.2	-	6	986	c.865G>A	c.(865-867)GGA>AGA	p.G289R		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	289					cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TCTATGGCTCCAGGGAGGGTG	0.597		NaN											0	0	0	0.007413	0	19	77									
NSUN2	54888	broad.mit.edu	37	5	6604332	6604332	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:6604332C>T	uc003jdu.2	-	17	1941	c.1876G>A	c.(1876-1878)GAT>AAT	p.D626N	NSUN2_uc003jds.2_Missense_Mutation_p.D72N|NSUN2_uc003jdt.2_Missense_Mutation_p.D390N|NSUN2_uc011cmk.1_Missense_Mutation_p.D591N|NSUN2_uc003jdv.2_Missense_Mutation_p.D390N	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	626						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						ATCTTAACATCTTCCATTGAT	0.363		NaN											0	0	0	0.003954	0	27	56									
MTRR	4552	broad.mit.edu	37	5	7870910	7870910	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:7870910G>A	uc003jed.2	+	2	114	c.84G>A	c.(82-84)ATG>ATA	p.M28I	FASTKD3_uc011cmp.1_5'Flank|FASTKD3_uc003jeb.2_5'Flank|FASTKD3_uc003jec.2_5'Flank|MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.M1I|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	28					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TTGAAGTGATGAGGAGGTTTC	0.403		NaN											0	0	0	0.01441	0	56	52									
SEMA5A	9037	broad.mit.edu	37	5	9202334	9202334	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:9202334G>A	uc003jek.2	-	9	1377	c.665C>T	c.(664-666)TCT>TTT	p.S222F		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	222	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GATGTCATAAGATGACACAAA	0.418		NaN											0	0	0	0.003163	0	15	29									
FAM134B	54463	broad.mit.edu	37	5	16475032	16475032	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:16475032G>C	uc003jfs.2	-	9	1350	c.1312C>G	c.(1312-1314)CAG>GAG	p.Q438E	FAM134B_uc003jfr.2_Missense_Mutation_p.Q297E	NM_001034850	NP_001030022	Q9H6L5	F134B_HUMAN	hypothetical protein LOC54463 isoform 1	438					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3						GGGGCAGCCTGAGAAAGTGCT	0.498		NaN											0	0	0	0.007413	0	18	55									
MYO10	4651	broad.mit.edu	37	5	16680071	16680071	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:16680071C>T	uc003jft.3	-	33	4995	c.4527G>A	c.(4525-4527)CTG>CTA	p.L1509L	MYO10_uc011cnb.1_Silent_p.L138L|MYO10_uc011cnc.1_Silent_p.L388L|MYO10_uc011cnd.1_Silent_p.L866L|MYO10_uc011cne.1_Silent_p.L866L|MYO10_uc010itx.2_Silent_p.L1131L	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1509					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TATCTTGAATCAGCTGCTGGG	0.537		NaN											0	0	0	0.001168	0	5	21									
PRDM9	56979	broad.mit.edu	37	5	23522739	23522739	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:23522739G>C	uc003jgo.2	+	8	809	c.627G>C	c.(625-627)CAG>CAC	p.Q209H		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	209					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGATGTGTCAGAACTTCTTCA	0.488		NaN								HNSCC(3;0.000094)			0	0	0	0.006214	0	9	24									
CDH6	1004	broad.mit.edu	37	5	31302360	31302360	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:31302360C>T	uc003jhe.1	+	6	1280	c.954C>T	c.(952-954)GTC>GTT	p.V318V	CDH6_uc003jhd.1_Silent_p.V318V	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	318	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGTTTGATGTCATCACCGACC	0.453		NaN											0	0	0	0.008291	0	11	47									
ADAMTS12	81792	broad.mit.edu	37	5	33641932	33641932	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:33641932C>T	uc003jia.1	-	11	1864	c.1701G>A	c.(1699-1701)AGG>AGA	p.R567R	ADAMTS12_uc010iuq.1_Silent_p.R567R	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	567	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGTTGCAGAGCCTCTCTGCGC	0.592		NaN								HNSCC(64;0.19)			0	0	0	0.010504	0	19	54									
CAPSL	133690	broad.mit.edu	37	5	35921175	35921175	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:35921175C>G	uc003jjt.1	-	2	143	c.48G>C	c.(46-48)AAG>AAC	p.K16N	CAPSL_uc003jju.1_Missense_Mutation_p.K16N	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	16						cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TGAGCTTTTTCTTGGCCTGGA	0.612		NaN											0	0	0	0.001855	0	14	35									
EGFLAM	133584	broad.mit.edu	37	5	38464063	38464063	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:38464063A>C	uc003jlc.1	+	23	3353	c.3029A>C	c.(3028-3030)AAC>ACC	p.N1010T	EGFLAM_uc003jlb.1_Missense_Mutation_p.N1002T|EGFLAM_uc003jle.1_Missense_Mutation_p.N768T|EGFLAM_uc003jlf.1_Missense_Mutation_p.N368T|EGFLAM_uc003jlg.1_Missense_Mutation_p.N145T|EGFLAM_uc003jlh.1_Missense_Mutation_p.N92T	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	1010	Laminin G-like 3.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					GATGGGAAAAACATCAACACT	0.532		NaN											0	0	0	0.006214	0	10	24									
OSMR	9180	broad.mit.edu	37	5	38904542	38904542	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:38904542G>C	uc003jln.1	+	9	1589	c.1222G>C	c.(1222-1224)GAT>CAT	p.D408H		NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	408	Fibronectin type-III 1.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					ACGGTGTGCTGATGCCAGCCA	0.478		NaN											0	0	0	0.00499	0	16	55									
RICTOR	253260	broad.mit.edu	37	5	38945050	38945050	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:38945050G>A	uc003jlp.2	-	35	4778	c.4754C>T	c.(4753-4755)TCA>TTA	p.S1585L	RICTOR_uc003jlo.2_Missense_Mutation_p.S1609L|RICTOR_uc010ivf.2_Missense_Mutation_p.S1262L	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1585					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GCTGCTAGCTGAGCCTTCTTG	0.403		NaN											0	0	0	0.00874	0	40	124									
CARD6	84674	broad.mit.edu	37	5	40853853	40853853	+	Missense_Mutation	SNP	C	C	T	rs34452222		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:40853853C>T	uc003jmg.2	+	3	2494	c.2419C>T	c.(2419-2421)CGG>TGG	p.R807W		NM_032587	NP_115976	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	807					apoptosis|regulation of apoptosis	intracellular				ovary(2)|skin(2)|lung(1)	5						CAGAGTTGCTCGGGGATGTCA	0.473		NaN											0	0	0	0.01441	0	87	300									
HEATR7B2	133558	broad.mit.edu	37	5	40998246	40998246	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:40998246G>A	uc003jmj.3	-	42	5156	c.4666C>T	c.(4666-4668)CGT>TGT	p.R1556C	HEATR7B2_uc003jmi.3_Missense_Mutation_p.R1111C	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1556							binding			ovary(6)|central_nervous_system(2)	8						GGATCTTGACGAAGTGCTTGG	0.483		NaN											0	0	0	0.01441	0	58	159									
HEATR7B2	133558	broad.mit.edu	37	5	41009477	41009477	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:41009477C>T	uc003jmj.3	-	32	3815	c.3325G>A	c.(3325-3327)GAA>AAA	p.E1109K	HEATR7B2_uc003jmi.3_Missense_Mutation_p.E664K	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1109							binding			ovary(6)|central_nervous_system(2)	8						GCTGGCTTTTCAGCCAGCGCC	0.498		NaN											0	0	0	0.008361	0	15	55									
HEATR7B2	133558	broad.mit.edu	37	5	41009499	41009499	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:41009499C>T	uc003jmj.3	-	32	3793	c.3303G>A	c.(3301-3303)AAG>AAA	p.K1101K	HEATR7B2_uc003jmi.3_Silent_p.K656K	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1101							binding			ovary(6)|central_nervous_system(2)	8						TCCACAATGTCTTTGTGTCCC	0.473		NaN											0	0	0	0.00278	0	23	76									
PELO	53918	broad.mit.edu	37	5	52096666	52096666	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:52096666C>T	uc003jos.2	+	2	1423	c.438C>T	c.(436-438)CTC>CTT	p.L146L	ITGA1_uc003jov.2_Intron|ITGA1_uc003jou.2_Intron|PELO_uc003jot.1_Intron	NM_015946	NP_057030	Q9BRX2	PELO_HUMAN	pelota homolog	146					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding				0		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				AGGAAGGCCTCGCCCATATCT	0.582		NaN											0	0	0	0.009096	0	4	16									
SNX18	112574	broad.mit.edu	37	5	53815651	53815651	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:53815651G>A	uc003jpj.3	+	1	2059	c.1869G>A	c.(1867-1869)ATG>ATA	p.M623I	SNX18_uc011cqg.1_Intron|SNX18_uc003jpi.3_Intron	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	623	BAR.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				TACCTTTGATGACAGTGCTAT	0.413		NaN											0	0	0	0.003163	0	15	44									
DHX29	54505	broad.mit.edu	37	5	54573026	54573026	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:54573026G>T	uc003jpx.2	-	13	2314	c.2194C>A	c.(2194-2196)CTA>ATA	p.L732I	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	732	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GCACTCATTAGAATCAAGTGT	0.368		NaN											1	0	1.08611e-07	0.010729	1.12018e-07	11	67									
CWC27	10283	broad.mit.edu	37	5	64267618	64267618	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:64267618G>A	uc003jtn.1	+	12	1350	c.1131G>A	c.(1129-1131)AAG>AAA	p.K377K	CWC27_uc010iwt.1_Silent_p.K377K	NM_005869	NP_005860	Q6UX04	CWC27_HUMAN	serologically defined colon cancer antigen 10	377	Potential.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity				0						AGTCAAAGAAGGGAACTTCCC	0.383		NaN											0	0	0	0.010729	0	11	40									
PIK3R1	5295	broad.mit.edu	37	5	67593263	67593263	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:67593263G>A	uc003jva.2	+	16	2569	c.2009G>A	c.(2008-2010)TGT>TAT	p.C670Y	PIK3R1_uc003jvb.2_Missense_Mutation_p.C670Y|PIK3R1_uc003jvc.2_Missense_Mutation_p.C370Y|PIK3R1_uc003jvd.2_Missense_Mutation_p.C400Y|PIK3R1_uc003jve.2_Missense_Mutation_p.C349Y	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1	670	SH2 2.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	GTAAAGCATTGTGTCATAAAC	0.433		NaN	Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			0	0	0	0.00623	0	40	114									
ENC1	8507	broad.mit.edu	37	5	73932241	73932241	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:73932241G>A	uc003kdc.3	-	2	1201	c.70C>T	c.(70-72)CAC>TAC	p.H24Y	ENC1_uc011css.1_Intron	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	24					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		GAGGACTTGTGAAACAGATAG	0.473		NaN											0	0	0	0.00245	0	13	30									
FAM169A	26049	broad.mit.edu	37	5	74101053	74101053	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:74101053C>T	uc003kdm.2	-	7	770	c.727G>A	c.(727-729)GAA>AAA	p.E243K	FAM169A_uc010izm.2_Missense_Mutation_p.E183K|FAM169A_uc003kdl.2_Missense_Mutation_p.E61K	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	243											0						CCAACACCTTCAACTTCCCAA	0.383		NaN											0	0	0	0.014323	0	24	67									
VCAN	1462	broad.mit.edu	37	5	82815228	82815228	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:82815228C>G	uc003kii.3	+	7	1459	c.1103C>G	c.(1102-1104)TCC>TGC	p.S368C	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Missense_Mutation_p.S368C|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	368	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCCAGTTTATCCAAAGAACCA	0.388		NaN											0	0	0	0.010771	0	42	89									
CCNH	902	broad.mit.edu	37	5	86700760	86700760	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:86700760C>T	uc003kjb.2	-	5	822	c.590G>A	c.(589-591)AGA>AAA	p.R197K	CCNH_uc003kiy.1_Intron|CCNH_uc003kiz.1_Missense_Mutation_p.R144K|CCNH_uc003kja.2_Missense_Mutation_p.R144K	NM_001239	NP_001230	P51946	CCNH_HUMAN	cyclin H	197					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		CAATGCAATTCTATTAAGAAA	0.408		NaN						Direct_reversal_of_damage|NER					0	0	0	0.004007	0	17	37									
CCNH	902	broad.mit.edu	37	5	86703827	86703827	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:86703827T>G	uc003kjb.2	-	4	723	c.491A>C	c.(490-492)TAC>TCC	p.Y164S	CCNH_uc003kiy.1_RNA|CCNH_uc003kiz.1_Missense_Mutation_p.Y111S|CCNH_uc003kja.2_Missense_Mutation_p.Y111S	NM_001239	NP_001230	P51946	CCNH_HUMAN	cyclin H	164					G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cyclin-dependent protein kinase activating kinase holoenzyme complex|holo TFIIH complex	protein kinase binding			ovary(2)|kidney(1)	3		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;9.01e-39)|Epithelial(54;5.08e-33)|all cancers(79;4.28e-28)		AAATGGTCTGTAAGGATTGTG	0.363		NaN						Direct_reversal_of_damage|NER					0	0	0	0.00632	0	27	48									
FAM172A	83989	broad.mit.edu	37	5	92956830	92956830	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:92956830C>T	uc010jbd.2	-	11	1321	c.1114G>A	c.(1114-1116)GAC>AAC	p.D372N	FAM172A_uc011cuf.1_Missense_Mutation_p.D326N|FAM172A_uc011cug.1_Missense_Mutation_p.D262N|FAM172A_uc011cuh.1_Missense_Mutation_p.D225N|FAM172A_uc011cui.1_RNA|FAM172A_uc011cuj.1_Silent_p.P101P|MIR2277_hsa-mir-2277|MI0011284_5'Flank	NM_032042	NP_114431	Q8WUF8	F172A_HUMAN	hypothetical protein LOC83989 isoform 1	372						endoplasmic reticulum|extracellular region					0						TCGTGACGGTCGGTGCCTGCA	0.607		NaN											0	0	0	0.00308	0	8	20									
MAN2A1	4124	broad.mit.edu	37	5	109202634	109202634	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:109202634C>T	uc003kou.1	+	22	4333	c.3370C>T	c.(3370-3372)CAG>TAG	p.Q1124*		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	1124	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TCCCGGCACTCAGAATATAAG	0.388		NaN											0	0	0	0.010818	0	33	77									
APC	324	broad.mit.edu	37	5	112111406	112111406	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:112111406G>C	uc010jby.2	+	5	883	c.503G>C	c.(502-504)AGA>ACA	p.R168T	APC_uc011cvt.1_Missense_Mutation_p.R178T|APC_uc003kpz.3_Missense_Mutation_p.R168T|APC_uc003kpy.3_Missense_Mutation_p.R168T|APC_uc010jbz.2_5'UTR	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	168	Leu-rich.|Potential.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CTCACTAAAAGAATAGATAGT	0.289		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			0	0	0	0.007291	0	29	57									
MCC	4163	broad.mit.edu	37	5	112418687	112418687	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:112418687C>T	uc003kqj.3	-	9	1614	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.E552K|MCC_uc011cwb.1_Missense_Mutation_p.E362K|MCC_uc010jcd.1_Missense_Mutation_p.E324K	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	362					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GCCAGGTGTTCAGCCACACTG	0.423		NaN											0	0	0	0.008871	0	20	47									
MCC	4163	broad.mit.edu	37	5	112458513	112458513	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:112458513C>T	uc003kqj.3	-	4	855	c.325G>A	c.(325-327)GAG>AAG	p.E109K	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Missense_Mutation_p.E299K|MCC_uc011cwb.1_Missense_Mutation_p.E109K|MCC_uc010jcd.1_Missense_Mutation_p.E71K	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	109					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		TCTGAGTACTCATCTTCCTCC	0.463		NaN											0	0	0	0.00245	0	14	28									
FEM1C	56929	broad.mit.edu	37	5	114878661	114878661	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:114878661C>G	uc003krb.1	-	2	1092	c.530G>C	c.(529-531)AGA>ACA	p.R177T		NM_020177	NP_064562	Q96JP0	FEM1C_HUMAN	feminization 1 homolog a	177	ANK 5.					cytoplasm				breast(2)|ovary(1)	3		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		GACACTTTTTCTATTAACATC	0.363		NaN											0	0	0	0.005443	0	27	83									
FEM1C	56929	broad.mit.edu	37	5	114879143	114879143	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:114879143G>A	uc003krb.1	-	2	610	c.48C>T	c.(46-48)CTC>CTT	p.L16L		NM_020177	NP_064562	Q96JP0	FEM1C_HUMAN	feminization 1 homolog a	16	ANK 1.					cytoplasm				breast(2)|ovary(1)	3		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		TGAGAAGCCGGAGTTTGCCAT	0.468		NaN											0	0	0	0.008361	0	31	30									
DMXL1	1657	broad.mit.edu	37	5	118533494	118533494	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:118533494C>T	uc003ksd.2	+	32	7769	c.7588C>T	c.(7588-7590)CTT>TTT	p.L2530F	DMXL1_uc010jcl.1_Missense_Mutation_p.L2530F	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2530										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TCTAAAAACTCTTCAATGTTG	0.403		NaN											0	0	0	0.008361	0	29	100									
DMXL1	1657	broad.mit.edu	37	5	118533569	118533569	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:118533569C>T	uc003ksd.2	+	32	7844	c.7663C>T	c.(7663-7665)CAT>TAT	p.H2555Y	DMXL1_uc010jcl.1_Missense_Mutation_p.H2555Y	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2555										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TATCGCAAGTCATACCGCCGA	0.428		NaN											0	0	0	0.009535	0	30	117									
SNCAIP	9627	broad.mit.edu	37	5	121758693	121758693	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:121758693G>A	uc003ksw.1	+	4	467	c.261G>A	c.(259-261)GAG>GAA	p.E87E	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Silent_p.E87E|SNCAIP_uc003ksx.1_Silent_p.E134E|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Silent_p.E87E	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	87					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ATCAGCCAGAGACTCTGGAGA	0.507		NaN											0	0	0	0.00499	0	17	35									
ZNF608	57507	broad.mit.edu	37	5	124036770	124036770	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:124036770C>G	uc003ktq.1	-	2	1222	c.1099G>C	c.(1099-1101)GGG>CGG	p.G367R	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Missense_Mutation_p.G367R|ZNF608_uc003ktt.1_Missense_Mutation_p.G367R	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	367						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TCACAGGGCCCAAGACACTCT	0.453		NaN											0	0	0	0.004007	0	15	66									
ZNF608	57507	broad.mit.edu	37	5	124036909	124036909	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:124036909G>A	uc003ktq.1	-	2	1083	c.960C>T	c.(958-960)CTC>CTT	p.L320L	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Silent_p.L320L|ZNF608_uc003ktt.1_Silent_p.L320L	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	320						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TCTGAGGCGTGAGACTGCTGG	0.512		NaN											0	0	0	0.010504	0	14	50									
ZNF608	57507	broad.mit.edu	37	5	124080028	124080028	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:124080028G>A	uc003ktq.1	-	1	778	c.655C>T	c.(655-657)CAG>TAG	p.Q219*	ZNF608_uc003ktr.1_RNA|ZNF608_uc003kts.1_Nonsense_Mutation_p.Q219*|ZNF608_uc003ktt.1_Nonsense_Mutation_p.Q219*	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	219						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		TGGTGGCCCTGAAGCAGGTCG	0.617		NaN											0	0	0	0.01441	0	41	29									
FNIP1	96459	broad.mit.edu	37	5	131039796	131039796	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:131039796C>G	uc003kvs.1	-	10	1220	c.1078G>C	c.(1078-1080)GAA>CAA	p.E360Q	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.E332Q|FNIP1_uc010jdm.1_Missense_Mutation_p.E315Q|FNIP1_uc003kvu.2_Missense_Mutation_p.E360Q	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	360					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		ATGTGGCTTTCAAAGAGAGGA	0.274		NaN											0	0	0	0.00245	0	14	55									
LEAP2	116842	broad.mit.edu	37	5	132209663	132209663	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:132209663G>C	uc003kyc.2	+	2	108	c.79G>C	c.(79-81)GAA>CAA	p.E27Q	LEAP2_uc003kyb.1_Missense_Mutation_p.E27Q	NM_052971	NP_443203	Q969E1	LEAP2_HUMAN	liver-expressed antimicrobial peptide 2	27					defense response to bacterium	extracellular region					0		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCAATACCAGAAGTGAGTTC	0.512		NaN											0	0	0	0.003271	0	34	20									
FSTL4	23105	broad.mit.edu	37	5	132534795	132534795	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:132534795C>T	uc003kyn.1	-	16	2739	c.2521G>A	c.(2521-2523)GAG>AAG	p.E841K	FSTL4_uc003kym.1_Missense_Mutation_p.E490K	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	841						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTCATACCTCACCCACCCAC	0.557		NaN											0	0	0	0.00308	0	7	21									
FSTL4	23105	broad.mit.edu	37	5	132535121	132535121	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:132535121G>A	uc003kyn.1	-	16	2413	c.2195C>T	c.(2194-2196)TCG>TTG	p.S732L	FSTL4_uc003kym.1_Missense_Mutation_p.S381L	NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	732						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TGAGATGCCCGAGTTTATTTG	0.572		NaN											0	0	0	0.004007	0	17	37									
C5orf15	56951	broad.mit.edu	37	5	133295697	133295697	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:133295697C>T	uc003kyo.2	-	2	285	c.154G>A	c.(154-156)GAT>AAT	p.D52N		NM_020199	NP_064584	Q8NC54	KCT2_HUMAN	keratinocytes associated transmembrane protein 2	52	Extracellular (Potential).					integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			CTCGGTGAATCAGTCCGTGAT	0.368		NaN											0	0	0	0.010504	0	19	32									
TIFAB	497189	broad.mit.edu	37	5	134785161	134785161	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:134785161G>C	uc003law.3	-	2	670	c.469C>G	c.(469-471)CCC>GCC	p.P157A	C5orf20_uc003lav.2_5'Flank	NM_001099221	NP_001092691	Q6ZNK6	TIFAB_HUMAN	TIFA-related protein TIFAB	157											0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GAACCAGGGGGAGGCTGCCCC	0.582		NaN											0	0	0	0.00499	0	18	68									
MATR3	9782	broad.mit.edu	37	5	138661216	138661216	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:138661216G>T	uc003ldu.2	+	16	2663	c.2236G>T	c.(2236-2238)GAA>TAA	p.E746*	MATR3_uc003ldt.2_Nonsense_Mutation_p.E408*|MATR3_uc003ldw.2_Nonsense_Mutation_p.E794*|MATR3_uc003ldx.2_Nonsense_Mutation_p.E746*|MATR3_uc010jfc.2_Nonsense_Mutation_p.E746*|MATR3_uc011czb.1_Nonsense_Mutation_p.E458*|MATR3_uc003ldz.2_Nonsense_Mutation_p.E746*|MATR3_uc003lea.2_Nonsense_Mutation_p.E746*|MATR3_uc003leb.2_Nonsense_Mutation_p.E408*|MATR3_uc003lec.2_Nonsense_Mutation_p.E423*	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	746						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACCAGGTGCTGAATCTTCTGA	0.408		NaN											1	0	1.33834e-09	0.007413	1.38957e-09	18	55									
MATR3	9782	broad.mit.edu	37	5	138665072	138665072	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:138665072G>C	uc003ldu.2	+	18	2959	c.2532G>C	c.(2530-2532)AAG>AAC	p.K844N	MATR3_uc003ldt.2_Missense_Mutation_p.K506N|MATR3_uc003ldw.2_Missense_Mutation_p.K892N|MATR3_uc003ldx.2_Missense_Mutation_p.K844N|MATR3_uc010jfc.2_3'UTR|MATR3_uc011czb.1_Missense_Mutation_p.K556N|MATR3_uc003ldz.2_Missense_Mutation_p.K844N|MATR3_uc003lea.2_Missense_Mutation_p.K844N|MATR3_uc003leb.2_Missense_Mutation_p.K506N|MATR3_uc003lec.2_Missense_Mutation_p.K521N	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	844						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GCAGACAGAAGAAGGAAACTT	0.289		NaN											0	0	0	0.004007	0	17	88									
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139905595	139905595	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:139905595C>T	uc003lfs.1	+	26	4631	c.4507C>T	c.(4507-4509)CCC>TCC	p.P1503S	ANKHD1_uc003lfr.2_Missense_Mutation_p.P1503S|ANKHD1_uc003lfu.1_Missense_Mutation_p.P983S|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.P242S|ANKHD1_uc003lfw.2_Missense_Mutation_p.P141S|ANKHD1_uc010jfl.2_5'UTR|ANKHD1-EIF4EBP3_uc003lfx.1_5'Flank	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	1503						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGAAGTTCCCATAGAACC	0.358		NaN											0	0	0	0.00278	0	24	76									
PCDHA9	9752	broad.mit.edu	37	5	140230192	140230192	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140230192C>G	uc003lhu.2	+	1	2836	c.2112C>G	c.(2110-2112)ATC>ATG	p.I704M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.I704M	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	704	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCATCGCCATCTGCGCGGTGT	0.662		NaN											0	0	0	0.009535	0	31	31									
PCDHAC1	56135	broad.mit.edu	37	5	140308755	140308755	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140308755C>T	uc003lih.2	+	1	2454	c.2278C>T	c.(2278-2280)CTG>TTG	p.L760L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Silent_p.L760L	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	760	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGGCCTCTCTGGGACTTGG	0.463		NaN											0	0	0	0.01441	0	54	66									
PCDHB1	29930	broad.mit.edu	37	5	140431478	140431478	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140431478G>A	uc003lik.1	+	1	500	c.423G>A	c.(421-423)AAG>AAA	p.K141K		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	141	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCTTTTAAAGATTCCGGAGA	0.547		NaN											0	0	0	0.00308	0	8	41									
PCDHB4	56131	broad.mit.edu	37	5	140502976	140502976	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140502976G>A	uc003lip.1	+	1	1396	c.1396G>A	c.(1396-1398)GCC>ACC	p.A466T		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	466	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAACAGCCCCGCCCTGCACAT	0.647		NaN											0	0	0	0.004289	0	26	44									
PCDHB11	56125	broad.mit.edu	37	5	140579748	140579748	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140579748C>T	uc003liy.2	+	1	401	c.401C>T	c.(400-402)TCG>TTG	p.S134L	PCDHB11_uc011daj.1_Intron	NM_018931	NP_061754	Q9Y5F2	PCDBB_HUMAN	protocadherin beta 11 precursor	134	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCATCTTCTCGGAAAAACAA	0.428		NaN											0	0	0	0.009718	0	43	151									
PCDHGA5	56110	broad.mit.edu	37	5	140744168	140744168	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140744168G>A	uc003lju.1	+	1	271	c.271G>A	c.(271-273)GAC>AAC	p.D91N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.D91N	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	91	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCAGGATAGACCGGGAGGA	0.542		NaN											0	0	0	0.00278	0	20	33									
PCDHGB6	56100	broad.mit.edu	37	5	140788029	140788029	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:140788029A>C	uc003lkj.1	+	1	260	c.260A>C	c.(259-261)AAG>ACG	p.K87T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.K87T	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	87	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTACTTGTGAAGAACCGAATA	0.488		NaN											0	0	0	0.00632	0	28	78									
YIPF5	81555	broad.mit.edu	37	5	143549462	143549462	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:143549462C>T	uc003lnk.3	-	2	499	c.58G>A	c.(58-60)GAT>AAT	p.D20N	KCTD16_uc003lnm.1_5'Flank|YIPF5_uc003lnl.3_Missense_Mutation_p.D20N|YIPF5_uc010jgl.2_Intron	NM_001024947	NP_001020118	Q969M3	YIPF5_HUMAN	Yip1 domain family, member 5	20	Cytoplasmic (Potential).				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi cisterna membrane|integral to membrane				ovary(1)|skin(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TGTGACTGATCATCGATGCTG	0.358		NaN											0	0	0	0.01441	0	82	55									
GRXCR2	643226	broad.mit.edu	37	5	145252343	145252343	+	Silent	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:145252343A>G	uc003lns.1	-	1	189	c.189T>C	c.(187-189)GGT>GGC	p.G63G		NM_001080516	NP_001073985	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	63											0						ACCCATAAACACCATCCATTG	0.498		NaN											0	0	0	0.01441	0	49	83									
STK32A	202374	broad.mit.edu	37	5	146763487	146763487	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:146763487C>A	uc010jgn.1	+	13	1412	c.1132C>A	c.(1132-1134)CTA>ATA	p.L378I	STK32A_uc011dbw.1_Missense_Mutation_p.L378I	NM_001112724	NP_001106195	Q8WU08	ST32A_HUMAN	serine/threonine kinase 32A isoform 1	378							ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAACCAAATCTAGCCTTGGA	0.338		NaN											1	0	8.00594e-06	0.007413	8.1909e-06	17	26									
GRPEL2	134266	broad.mit.edu	37	5	148730750	148730750	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:148730750G>A	uc003lqj.2	+	4	709	c.583G>A	c.(583-585)GTG>ATG	p.V195M	GRPEL2_uc011dca.1_3'UTR	NM_152407	NP_689620	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial precursor	195					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTGGCACCGTGGCATTAGT	0.532		NaN											0	0	0	0.01441	0	55	59									
SLC36A1	206358	broad.mit.edu	37	5	150847396	150847396	+	Silent	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:150847396C>A	uc003luc.2	+	7	850	c.633C>A	c.(631-633)ATC>ATA	p.I211I	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Silent_p.I211I|SLC36A1_uc010jhw.1_Silent_p.I211I	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	211	Helical; Name=4; (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TGGTTTTCATCAGGAACCTCC	0.522		NaN											1	0	2.39187e-15	0.008871	2.51349e-15	18	56									
CCNJL	79616	broad.mit.edu	37	5	159682612	159682612	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:159682612C>T	uc003lyb.1	-	6	1083	c.831G>A	c.(829-831)CAG>CAA	p.Q277Q	CCNJL_uc011dee.1_Silent_p.Q229Q|CCNJL_uc003lyc.1_RNA|CCNJL_uc011def.1_Silent_p.Q229Q	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	277						nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGAGATCCTCTGCAGGTCTC	0.507		NaN											0	0	0	0.01441	0	76	78									
ODZ2	57451	broad.mit.edu	37	5	167655045	167655045	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:167655045G>A	uc010jjd.2	+	25	5403	c.5403G>A	c.(5401-5403)CTG>CTA	p.L1801L	ODZ2_uc003lzr.3_Silent_p.L1571L|ODZ2_uc003lzt.3_Silent_p.L1174L|ODZ2_uc010jje.2_Silent_p.L1065L	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACATCTCCCTGCCTATGGAGA	0.527		NaN											0	0	0	0.010729	0	10	4									
DOCK2	1794	broad.mit.edu	37	5	169122855	169122855	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:169122855C>T	uc003maf.2	+	10	972	c.892C>T	c.(892-894)CAA>TAA	p.Q298*	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	298					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTGATTTGTCAAATAGTCCG	0.473		NaN											0	0	0	0.01441	0	52	45									
KCNIP1	30820	broad.mit.edu	37	5	170159845	170159845	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:170159845G>A	uc003mas.2	+	7	1039	c.510G>A	c.(508-510)GGG>GGA	p.G170G	KCNIP1_uc003map.2_Silent_p.G168G|KCNIP1_uc003mat.2_Silent_p.G159G|KCNIP1_uc010jjp.2_Silent_p.G131G|KCNIP1_uc010jjq.2_Silent_p.G184G	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	170					detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATGATGGGGAAATACACAT	0.493		NaN											0	0	0	0.010504	0	19	44									
STK10	6793	broad.mit.edu	37	5	171517361	171517361	+	Silent	SNP	C	C	T	rs148086376		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:171517361C>T	uc003mbo.1	-	10	1860	c.1560G>A	c.(1558-1560)CCG>CCA	p.P520P		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	520							ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGTACAGTTTCGGGTCCTGGC	0.532		NaN											0	0	0	0.01441	0	44	129									
CPLX2	10814	broad.mit.edu	37	5	175306917	175306917	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:175306917G>C	uc003mde.1	+	5	620	c.274G>C	c.(274-276)GGG>CGG	p.G92R	CPLX2_uc003mdf.1_Missense_Mutation_p.G92R	NM_006650	NP_006641	Q6PUV4	CPLX2_HUMAN	complexin 2	92	Interaction with the SNARE complex (By similarity).				mast cell degranulation|positive regulation of synaptic plasticity|vesicle docking involved in exocytosis	cytosol				ovary(1)	1	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCCCTGCGAGGGGAGCCTGAC	0.642		NaN											0	0	0	0.001168	0	5	17									
HIGD2A	192286	broad.mit.edu	37	5	175816403	175816403	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:175816403C>T	uc003meg.2	+	2	263	c.226C>T	c.(226-228)CAG>TAG	p.Q76*	NOP16_uc003med.2_5'Flank|NOP16_uc003mee.2_5'Flank|NOP16_uc011dfl.1_5'Flank|NOP16_uc011dfm.1_5'Flank	NM_138820	NP_620175	Q9BW72	HIG2A_HUMAN	HIG1 hypoxia inducible domain family, member 2A	76	Extracellular (Potential).|HIG1.					integral to membrane					0	all_cancers(89;0.00522)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.0965)		CCAGCGCTCTCAGCTCATGAT	0.637		NaN											0	0	0	0.01441	0	45	69									
HK3	3101	broad.mit.edu	37	5	176309065	176309065	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:176309065G>C	uc003mfa.2	-	16	2209	c.2117C>G	c.(2116-2118)TCA>TGA	p.S706*	HK3_uc003mez.2_Nonsense_Mutation_p.S262*	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	706	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATGCGGCCTGAGTCCCCAGG	0.617		NaN											0	0	0	0.004007	0	16	23									
NSD1	64324	broad.mit.edu	37	5	176562564	176562564	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:176562564G>C	uc003mfr.3	+	2	598	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	NSD1_uc003mft.3_Intron|NSD1_uc003mfs.1_Missense_Mutation_p.E154Q|NSD1_uc011dfx.1_Intron|NSD1_uc003mfp.2_Missense_Mutation_p.E154Q|NSD1_uc003mfq.2_Missense_Mutation_p.E154Q	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	154					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCTGCACTTTGAGAATTTTAC	0.423		NaN	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.010504	0	22	107									
NSD1	64324	broad.mit.edu	37	5	176721473	176721473	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:176721473C>G	uc003mfr.3	+	23	7242	c.7104C>G	c.(7102-7104)GCC>GCG	p.A2368A	NSD1_uc003mft.3_Silent_p.A2099A|NSD1_uc011dfx.1_Silent_p.A2016A	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2368	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TAGGTGCTGCCAGCCCAAGGC	0.587		NaN	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			0	0	0	0.010729	0	9	56									
GRK6	2870	broad.mit.edu	37	5	176867977	176867977	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:176867977C>T	uc011dfz.1	+	15	1760	c.1600C>T	c.(1600-1602)CCC>TCC	p.P534S	GRK6_uc003mgq.2_Missense_Mutation_p.P534S|GRK6_uc003mgs.1_Missense_Mutation_p.P504S|uc003mgt.2_Intron	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	534					regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGGCTCAGTTCCCCCAGACCT	0.612		NaN											0	0	0	0.008291	0	11	37									
ZFP2	80108	broad.mit.edu	37	5	178359071	178359071	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:178359071C>T	uc003mjn.1	+	5	1266	c.757C>T	c.(757-759)CAA>TAA	p.Q253*	ZFP2_uc010jky.2_Nonsense_Mutation_p.Q253*|ZFP2_uc010jkx.1_Nonsense_Mutation_p.Q253*	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	253	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		AGCCTTCAGTCAAAGCATGCA	0.383		NaN											0	0	0	0.008871	0	18	72									
ADAMTS2	9509	broad.mit.edu	37	5	178554964	178554964	+	Silent	SNP	G	G	A	rs145016043	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:178554964G>A	uc003mjw.2	-	17	2613	c.2613C>T	c.(2611-2613)GGC>GGT	p.G871G		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	871	TSP type-1 2.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCTCACCTCCGCCACAGGGCT	0.627		NaN											0	0	0	0.00632	0	27	75									
SQSTM1	8878	broad.mit.edu	37	5	179251010	179251010	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:179251010A>T	uc003mkw.3	+	3	549	c.454A>T	c.(454-456)AGC>TGC	p.S152C	SQSTM1_uc011dgr.1_Missense_Mutation_p.S68C|SQSTM1_uc011dgs.1_Missense_Mutation_p.S68C|SQSTM1_uc003mkv.3_Missense_Mutation_p.S152C|SQSTM1_uc003mkx.2_Missense_Mutation_p.S68C	NM_003900	NP_003891	Q13501	SQSTM_HUMAN	sequestosome 1 isoform 1	152	ZZ-type.|Interaction with GABRR3 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGACTTGTGTAGCGTCTGCGA	0.627		NaN							Paget_Disease_of_Bone				0	0	0	0.007413	0	18	41									
GFPT2	9945	broad.mit.edu	37	5	179763570	179763570	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:179763570C>T	uc003mlw.1	-	3	221	c.123G>A	c.(121-123)GCG>GCA	p.A41A		NM_005110	NP_005101	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	41	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			ovary(1)|skin(1)	2	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	TCCCATCGATCGCCACACCTG	0.478		NaN											0	0	0	0.01441	0	166	125									
OR2V2	285659	broad.mit.edu	37	5	180582627	180582627	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:180582627A>G	uc011dhj.1	+	1	685	c.685A>G	c.(685-687)ATG>GTG	p.M229V		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTGCTGCAAATGCACTCTGC	0.527		NaN											0	0	0	0.012213	0	34	158									
RIOK1	83732	broad.mit.edu	37	6	7398940	7398940	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:7398940C>G	uc003mxn.2	+	5	621	c.447C>G	c.(445-447)ATC>ATG	p.I149M	RIOK1_uc003mxm.1_Missense_Mutation_p.I45M	NM_031480	NP_113668	Q9BRS2	RIOK1_HUMAN	RIO kinase 1 isoform 1	149							ATP binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|skin(1)	4	Ovarian(93;0.0418)					GGTATCGCATCAAAGATAAGG	0.313		NaN											0	0	0	0.00278	0	22	30									
DSP	1832	broad.mit.edu	37	6	7583091	7583091	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:7583091C>T	uc003mxp.1	+	24	5875	c.5596C>T	c.(5596-5598)CAG>TAG	p.Q1866*	DSP_uc003mxq.1_Nonsense_Mutation_p.Q1267*	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1866	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TGACCTGAATCAGTGGAAGAC	0.453		NaN											0	0	0	0.012319	0	22	37									
SYCP2L	221711	broad.mit.edu	37	6	10907799	10907799	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:10907799C>G	uc003mzo.2	+	10	997	c.701C>G	c.(700-702)TCT>TGT	p.S234C	SYCP2L_uc011din.1_Missense_Mutation_p.S75C|SYCP2L_uc010jow.2_5'UTR	NM_001040274	NP_001035364	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	234						nucleus				ovary(1)|skin(1)	2	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			GTTGCTATTTCTGAAGCGCTG	0.348		NaN											0	0	0	0.00623	0	38	45									
HIVEP1	3096	broad.mit.edu	37	6	12123091	12123091	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:12123091C>T	uc003nac.2	+	4	3242	c.3063C>T	c.(3061-3063)ATC>ATT	p.I1021I	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1021					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CCTCCGGCATCTGGGAACAGA	0.488		NaN											0	0	0	0.00874	0	35	894									
KIF13A	63971	broad.mit.edu	37	6	17804706	17804706	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:17804706G>A	uc003ncg.3	-	20	2445	c.2340C>T	c.(2338-2340)TTC>TTT	p.F780F	KIF13A_uc003ncf.2_Silent_p.F780F|KIF13A_uc003nch.3_Silent_p.F780F|KIF13A_uc003nci.3_Silent_p.F780F	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	780					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GGGCTTCATAGAAAGGGTCAC	0.423		NaN											0	0	0	0.012319	0	21	6									
CDKAL1	54901	broad.mit.edu	37	6	21065357	21065357	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:21065357G>A	uc003ndc.1	+	12	1308	c.1134G>A	c.(1132-1134)GTG>GTA	p.V378V	CDKAL1_uc003ndd.1_Silent_p.V378V|CDKAL1_uc003nde.1_Silent_p.V308V|CDKAL1_uc003ndf.1_5'UTR	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	378					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			AAGAAACAGTGAAACTTGTTG	0.368		NaN											0	0	0	0.014323	0	22	504									
CDKAL1	54901	broad.mit.edu	37	6	21231097	21231097	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:21231097G>A	uc003ndc.1	+	16	1741	c.1567G>A	c.(1567-1569)GGG>AGG	p.G523R	CDKAL1_uc003ndd.1_Missense_Mutation_p.G523R|CDKAL1_uc003nde.1_Missense_Mutation_p.G432R|CDKAL1_uc003ndf.1_Missense_Mutation_p.G36R|CDKAL1_uc003ndg.2_RNA	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	523					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			AAATGGGCTTGGGAACCAGCT	0.463		NaN											0	0	0	0.010504	0	20	327									
HIST1H3C	8352	broad.mit.edu	37	6	26045930	26045930	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26045930G>A	uc003nfv.2	+	1	292	c.292G>A	c.(292-294)GAG>AAG	p.E98K	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	98					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GGAGGCTTGTGAGGCCTACCT	0.577		NaN											0	0	0	0.00245	0	15	27									
HIST1H2BD	3017	broad.mit.edu	37	6	26158404	26158404	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26158404G>A	uc003ngr.2	+	1	56	c.7G>A	c.(7-9)GAA>AAA	p.E3K	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.E3K	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	3					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						TACGATGCCTGAACCTACCAA	0.507		NaN											0	0	0	0.003163	0	15	51									
HIST1H2BD	3017	broad.mit.edu	37	6	26158626	26158626	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26158626G>A	uc003ngr.2	+	1	278	c.229G>A	c.(229-231)GAG>AAG	p.E77K	HIST1H2BD_uc003ngs.2_Missense_Mutation_p.E77K	NM_021063	NP_066407	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	77					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|pancreas(1)	2						CATCGCAGGCGAGGCTTCCCG	0.612		NaN											0	0	0	0.01441	0	45	94									
HIST1H2BE	8344	broad.mit.edu	37	6	26184336	26184336	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26184336G>C	uc003ngt.2	+	1	313	c.313G>C	c.(313-315)GGG>CGG	p.G105R		NM_003523	NP_003514	P62807	H2B1C_HUMAN	histone cluster 1, H2be	105					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						GCTGCTTCCCGGGGAGCTGGC	0.617		NaN											0	0	0	0.006122	0	18	52									
HIST1H2AE	3012	broad.mit.edu	37	6	26217568	26217568	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26217568G>A	uc003nha.1	+	1	421	c.366G>A	c.(364-366)GAG>GAA	p.E122E	HIST1H2BG_uc003ngz.2_5'Flank	NM_021052	NP_066390	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	122					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2		all_hematologic(11;0.196)				AGAAGACGGAGAGCCACCATA	0.542		NaN											0	0	0	0.010729	0	8	21									
BTN3A2	11118	broad.mit.edu	37	6	26368410	26368410	+	Splice_Site	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:26368410G>C	uc010jqh.1	+	3	260	c.1_splice	c.e3-1	p.M1_splice	BTN3A2_uc003nho.1_5'UTR|BTN3A2_uc003nhp.2_5'UTR|BTN3A2_uc011dkd.1_Intron|BTN3A2_uc011dke.1_Intron|BTN3A2_uc010jqi.1_5'UTR	NM_007047	NP_008978	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2 precursor							integral to membrane					0						ATGCAGCATAGATGAAAATGG	0.493		NaN											0	0	0	0.011902	0	36	57									
HIST1H1B	3009	broad.mit.edu	37	6	27834692	27834692	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:27834692C>T	uc003njx.2	-	1	668	c.616G>A	c.(616-618)GCT>ACT	p.A206T		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	206					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						TTGGGCTTAGCGGCTTTGGGC	0.552		NaN											0	0	0	0.010729	0	10	44									
ZNF192	7745	broad.mit.edu	37	6	28120950	28120950	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:28120950G>C	uc003nkn.1	+	6	1076	c.892G>C	c.(892-894)GAG>CAG	p.E298Q	ZNF192_uc010jqx.1_Missense_Mutation_p.E298Q|ZNF192_uc010jqy.1_Missense_Mutation_p.E111Q|ZNF192_uc011dkz.1_Missense_Mutation_p.E111Q	NM_006298	NP_006289	Q15776	ZN192_HUMAN	zinc finger protein 192	298	KRAB.				viral reproduction	cytoplasm|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CAGGGGTCTTGAGCATGAAGA	0.478		NaN											0	0	0	0.00499	0	18	52									
PPP1R10	5514	broad.mit.edu	37	6	30574287	30574287	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:30574287G>C	uc003nqn.1	-	8	1144	c.592C>G	c.(592-594)CTT>GTT	p.L198V	PPP1R10_uc010jsc.1_5'UTR	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	198	Interaction with TOX4 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GTGGTGCGAAGAGACTTGGGC	0.577		NaN											0	0	0	0.007413	0	16	72									
C6orf136	221545	broad.mit.edu	37	6	30617717	30617717	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:30617717A>G	uc003nqw.3	+	2	648	c.455A>G	c.(454-456)TAT>TGT	p.Y152C	C6orf136_uc003nqx.3_Missense_Mutation_p.Y333C|C6orf136_uc011dmn.1_Intron	NM_001109938	NP_001103408	Q5SQH8	CF136_HUMAN	hypothetical protein LOC221545 isoform 1	152											0						TCTGTCATGTATGAGAGACTG	0.527		NaN											0	0	0	0.010504	0	20	53									
BAT5	7920	broad.mit.edu	37	6	31670992	31670992	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:31670992C>T	uc003nvy.1	-	1	97	c.67G>A	c.(67-69)GAA>AAA	p.E23K	BAT5_uc003nvx.1_5'Flank|BAT5_uc011dny.1_5'Flank|BAT5_uc003nvz.1_5'UTR|BAT5_uc011dnz.1_Intron|BAT5_uc010jtc.1_RNA|BAT5_uc011doa.1_5'UTR	NM_021160	NP_066983	O95870	ABHGA_HUMAN	HLA-B associated transcript 5	23						integral to membrane	hydrolase activity|protein binding				0						GGGGCCCTTTCAGAGTCCCTC	0.657		NaN											0	0	0	0.00333	0	18	28									
DOM3Z	1797	broad.mit.edu	37	6	31938901	31938901	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:31938901G>T	uc003nyo.1	-	2	914	c.380C>A	c.(379-381)GCC>GAC	p.A127D	DOM3Z_uc003nyp.1_Missense_Mutation_p.A127D|DOM3Z_uc003nyq.1_5'UTR|DOM3Z_uc003nyr.1_Missense_Mutation_p.A127D|DOM3Z_uc003nys.1_Missense_Mutation_p.A127D|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	127							identical protein binding|metal ion binding|nucleotide binding				0						CGTCACTATGGCCTCTGCCAG	0.587		NaN											1	0	1.75199e-13	0.007291	1.83485e-13	17	21									
TNXB	7148	broad.mit.edu	37	6	32024681	32024681	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:32024681C>T	uc003nzl.2	-	23	8028	c.7826_splice	c.e23-1	p.E2609_splice		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor						actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GCTTCATCCTCTGGAGTTGGA	0.582		NaN											0	0	0	0.00499	0	14	41									
PBX2	5089	broad.mit.edu	37	6	32157485	32157485	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:32157485C>T	uc003oav.1	-	1	479	c.208G>A	c.(208-210)GAG>AAG	p.E70K	PBX2_uc003oaw.2_Missense_Mutation_p.E70K	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	70							transcription factor binding			ovary(1)	1						GCCTGGGCCTCGTCCAGGCTC	0.647		NaN											0	0	0	0.003163	0	15	34									
HLA-DOA	3111	broad.mit.edu	37	6	32977305	32977305	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:32977305G>A	uc003ocr.2	-	1	85	c.9C>T	c.(7-9)CTC>CTT	p.L3L	HLA-DOA_uc010juj.2_5'UTR|HLA-DOA_uc010jui.2_Silent_p.L3L	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	3					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						GCCCTGCTCTGAGGGCCATTA	0.587		NaN											0	0	0	0.009096	0	4	19									
B3GALT4	8705	broad.mit.edu	37	6	33245448	33245448	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:33245448G>C	uc003odr.2	+	1	532	c.252G>C	c.(250-252)CTG>CTC	p.L84L		NM_003782	NP_003773	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta	84	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)|breast(1)	2						CGGAGAACCTGAACCAGAGAA	0.667		NaN											0	0	0	0.004289	0	36	82									
WDR46	9277	broad.mit.edu	37	6	33247078	33247078	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:33247078G>C	uc003ods.2	-	15	1852	c.1808C>G	c.(1807-1809)TCT>TGT	p.S603C	WDR46_uc011dra.1_Missense_Mutation_p.S549C	NM_005452	NP_005443	O15213	WDR46_HUMAN	WD repeat domain 46 isoform 1	603											0						GTCCAGGGCAGATGGCCGGGC	0.612		NaN											0	0	0	0.010818	0	29	137									
UHRF1BP1	54887	broad.mit.edu	37	6	34831871	34831871	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:34831871C>T	uc003oju.3	+	15	3542	c.3308C>T	c.(3307-3309)TCT>TTT	p.S1103F	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_Intron	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1103										ovary(3)	3						AGGACGGTATCTCAACAGTCA	0.522		NaN											0	0	0	0.008871	0	16	49									
C6orf222	389384	broad.mit.edu	37	6	36291244	36291244	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:36291244G>C	uc003oly.2	-	8	1475	c.1297C>G	c.(1297-1299)CAA>GAA	p.Q433E		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	433										skin(2)|ovary(1)|breast(1)	4						CTTTTTTCTTGAGATTTCCTT	0.562		NaN											0	0	0	0.01441	0	52	171									
KCTD20	222658	broad.mit.edu	37	6	36452534	36452534	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:36452534G>A	uc003ome.2	+	7	1291	c.900G>A	c.(898-900)GAG>GAA	p.E300E	KCTD20_uc011dtm.1_Silent_p.E155E|KCTD20_uc011dtn.1_Silent_p.E54E|KCTD20_uc010jwk.2_Silent_p.E134E|KCTD20_uc011dto.1_Silent_p.E54E	NM_173562	NP_775833	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerisation domain	300						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2						AATATATTGAGAATAGGGATG	0.343		NaN											0	0	0	0.01441	0	125	109									
CDKN1A	1026	broad.mit.edu	37	6	36652272	36652272	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:36652272G>T	uc003omm.3	+	2	516	c.394G>T	c.(394-396)GGT>TGT	p.G132C	CDKN1A_uc011dtq.1_Missense_Mutation_p.G166C|CDKN1A_uc003oml.2_Missense_Mutation_p.G132C|CDKN1A_uc003omn.2_Missense_Mutation_p.G132C	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	132					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						AGGGTCCCCAGGTGGACCTGG	0.592		NaN							Multiple_Endocrine_Neoplasia_type_1				1	0	9.05144e-12	0.001855	9.45218e-12	12	27									
FTSJD2	23070	broad.mit.edu	37	6	37419600	37419600	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:37419600G>C	uc003ons.2	+	6	809	c.556G>C	c.(556-558)GAT>CAT	p.D186H	FTSJD2_uc010jwu.2_Missense_Mutation_p.D186H	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	186					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GATTATTGAAGATGAAACAGA	0.423		NaN											0	0	0	0.00278	0	22	62									
DAAM2	23500	broad.mit.edu	37	6	39865036	39865036	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:39865036C>G	uc003oow.2	+	21	2752	c.2596C>G	c.(2596-2598)CTT>GTT	p.L866V	DAAM2_uc003oox.2_Missense_Mutation_p.L866V	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	866	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					GCTGCAACATCTTCCAGAAGC	0.448		NaN											0	0	0	0.003755	0	34	80									
MOCS1	4337	broad.mit.edu	37	6	39895072	39895072	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:39895072G>A	uc003opb.2	-	1	384	c.246C>T	c.(244-246)CTC>CTT	p.L82L	MOCS1_uc003opa.2_Silent_p.L82L|MOCS1_uc003opc.2_Silent_p.L82L|MOCS1_uc003opd.2_Silent_p.L82L|MOCS1_uc003ope.2_Intron	NM_005942	NP_005933	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis-step 1 protein	82	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			ovary(1)|liver(1)|central_nervous_system(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					ACTCACATCTGAGGTTGCACT	0.602		NaN											0	0	0	0.00308	0	8	74									
TREML1	340205	broad.mit.edu	37	6	41121535	41121535	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:41121535G>A	uc011duc.1	-	2	381	c.337C>T	c.(337-339)CAG>TAG	p.Q113*	TREML1_uc003opx.2_Nonsense_Mutation_p.Q113*|TREML1_uc011dud.1_Intron	NM_178174	NP_835468	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid	113	Ig-like V-type.|Extracellular (Potential).				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCAAAATCTGGGGCCCCCTG	0.607		NaN											0	0	0	0.01441	0	102	37									
TREM2	54209	broad.mit.edu	37	6	41129313	41129313	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:41129313C>T	uc003opy.2	-	2	181	c.79G>A	c.(79-81)GTG>ATG	p.V27M	TREM2_uc003opz.2_Missense_Mutation_p.V57M|TREM2_uc010jxl.1_Missense_Mutation_p.V57M	NM_018965	NP_061838	Q9NZC2	TREM2_HUMAN	triggering receptor expressed on myeloid cells 2	27	Extracellular (Potential).				axon guidance|humoral immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(1)	1	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGCCCGCCACGCCCTGGAAC	0.493		NaN											0	0	0	0.010729	0	5	51									
UBR2	23304	broad.mit.edu	37	6	42532121	42532121	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:42532121G>T	uc011dur.1	+	1	64	c.64G>T	c.(64-66)GAG>TAG	p.E22*	UBR2_uc003osf.2_Nonsense_Mutation_p.E22*	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	22					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			ATGTTCGGCCGAGGAGATTGC	0.697		NaN											1	0	2.17888e-05	0.006214	2.22502e-05	9	7									
TBCC	6903	broad.mit.edu	37	6	42713401	42713401	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:42713401G>A	uc003osl.2	-	1	484	c.411C>T	c.(409-411)TTC>TTT	p.F137F		NM_003192	NP_003183	Q15814	TBCC_HUMAN	beta-tubulin cofactor C	137					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|photoreceptor connecting cilium	chaperone binding|GTPase activity				0	Colorectal(47;0.196)		all cancers(41;0.00122)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.125)			TCTTGAAAGCGAAACGCTTCT	0.662		NaN											0	0	0	0.001984	0	6	41									
MEA1	4201	broad.mit.edu	37	6	42981053	42981053	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:42981053C>T	uc003otk.2	-	2	170	c.103G>A	c.(103-105)GAG>AAG	p.E35K	MEA1_uc010jyc.1_Missense_Mutation_p.E22K|KLHDC3_uc003otl.2_5'Flank|KLHDC3_uc003otm.2_5'Flank|KLHDC3_uc010jyf.2_5'Flank|KLHDC3_uc003otn.2_5'Flank	NM_014623	NP_055438	Q16626	MEA1_HUMAN	male-enhanced antigen	35					cell differentiation|male gonad development|spermatogenesis		protein binding			central_nervous_system(1)|skin(1)	2			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCCAGTTCCTCAGTCTGATTG	0.522		NaN											0	0	0	0.008361	0	28	157									
CUL9	23113	broad.mit.edu	37	6	43181188	43181188	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:43181188G>C	uc003ouk.2	+	28	5446	c.5371G>C	c.(5371-5373)GAG>CAG	p.E1791Q	CUL9_uc003oul.2_Missense_Mutation_p.E1791Q|CUL9_uc010jyk.2_Missense_Mutation_p.E943Q|CUL9_uc003oun.2_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1791					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GGTGTCAGTAGAGACCTTGCT	0.557		NaN											0	0	0	0.001855	0	13	96									
CUL9	23113	broad.mit.edu	37	6	43190340	43190340	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:43190340C>T	uc003ouk.2	+	37	7068	c.6993C>T	c.(6991-6993)TTC>TTT	p.F2331F	CUL9_uc003oul.2_Silent_p.F2303F|CUL9_uc010jyk.2_Silent_p.F1483F|CUL9_uc003oun.2_Silent_p.F126F	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	2331					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CCTTCACCTTCCTCAATGATG	0.607		NaN											0	0	0	0.00632	0	27	39									
ZNF318	24149	broad.mit.edu	37	6	43323779	43323779	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:43323779C>T	uc003oux.2	-	4	1371	c.1293G>A	c.(1291-1293)GAG>GAA	p.E431E	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	431					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TGTTTTCAATCTCTGAGGCAA	0.522		NaN											0	0	0	0.01441	0	72	84									
C6orf154	221424	broad.mit.edu	37	6	43475602	43475602	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:43475602C>T	uc003ovk.1	-	4	1520	c.619G>A	c.(619-621)GAC>AAC	p.D207N	C6orf154_uc003ovj.1_Missense_Mutation_p.D16N	NM_001012974	NP_001012992	Q5JTD7	CF154_HUMAN	hypothetical protein LOC221424	207	LRR 6.										0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			CCCTCCAAGTCTAGGACCTCT	0.562		NaN											0	0	0	0.001984	0	7	36									
GPR110	266977	broad.mit.edu	37	6	46977464	46977464	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:46977464G>A	uc003oyt.2	-	11	1906	c.1707C>T	c.(1705-1707)TTC>TTT	p.F569F	GPR110_uc011dwl.1_Silent_p.F257F	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1	569	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						TCAATATGGAGAAGGAGGTCA	0.358		NaN											0	0	0	0.00499	0	16	67									
CRISP3	10321	broad.mit.edu	37	6	49700942	49700942	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:49700942G>C	uc003ozs.2	-	6	502	c.487C>G	c.(487-489)CTA>GTA	p.L163V		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	163					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TAGTATTTTAGAACTTTTTGA	0.303		NaN											0	0	0	0.00623	0	40	161									
PGK2	5232	broad.mit.edu	37	6	49753659	49753659	+	Silent	SNP	G	G	A	rs142237772	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:49753659G>A	uc003ozu.2	-	1	1349	c.1242C>T	c.(1240-1242)CTC>CTT	p.L414L		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	414					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					ACATGTTGCTGAGGGCCTCTA	0.433		NaN											0	0	0	0.006999	0	38	60									
PKHD1	5314	broad.mit.edu	37	6	51612670	51612670	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:51612670G>A	uc003pah.1	-	58	10020	c.9744C>T	c.(9742-9744)TTC>TTT	p.F3248F	PKHD1_uc010jzn.1_Silent_p.F1231F|PKHD1_uc003pai.2_Silent_p.F3248F	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3248	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					GTTCTGAGGTGAATACAGGCC	0.448		NaN											0	0	0	0.01441	0	53	97									
IL17F	112744	broad.mit.edu	37	6	52103570	52103570	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:52103570G>C	uc003pam.1	-	2	283	c.212C>G	c.(211-213)TCA>TGA	p.S71*	IL17F_uc003pal.1_Nonsense_Mutation_p.S17*	NM_052872	NP_443104	Q96PD4	IL17F_HUMAN	interleukin 17F precursor	71					cartilage development|inflammatory response|lymphotoxin A biosynthetic process|negative regulation of angiogenesis|proteoglycan metabolic process|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of interleukin-6 biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|cytokine binding|protein homodimerization activity			ovary(1)	1	Lung NSC(77;0.116)					GATGTTACGTGACATGGAAAC	0.438		NaN											0	0	0	0.010729	0	11	48									
MCM3	4172	broad.mit.edu	37	6	52129560	52129560	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:52129560G>C	uc003pan.1	-	17	2363	c.2253C>G	c.(2251-2253)CTC>CTG	p.L751L	MCM3_uc011dwu.1_Silent_p.L705L	NM_002388	NP_002379	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	751					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)|lung(1)|skin(1)	3	Lung NSC(77;0.0931)					ACACATCCAAGAGGGCCACCT	0.507		NaN											0	0	0	0.01441	0	56	91									
GSTA5	221357	broad.mit.edu	37	6	52701150	52701150	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:52701150G>A	uc003pba.1	-	4	226	c.156C>T	c.(154-156)TTC>TTT	p.F52F		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	52	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	GTACTTGCTGGAACAGCAAAC	0.403		NaN											0	0	0	0.008361	0	30	149									
LRRC1	55227	broad.mit.edu	37	6	53660187	53660187	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:53660187G>C	uc003pcd.1	+	1	410	c.133G>C	c.(133-135)GCC>CCC	p.A45P		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	45	LRR 2.					cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		GCTGCTGGACGCCAACCAGCT	0.667		NaN											0	0	0	0.004007	0	12	13									
BMP5	653	broad.mit.edu	37	6	55739327	55739327	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:55739327T>C	uc003pcq.2	-	1	1049	c.337A>G	c.(337-339)AGA>GGA	p.R113G	BMP5_uc011dxf.1_Missense_Mutation_p.R113G	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	113					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TATCCCTTTCTTGCCCCTCTG	0.522		NaN											0	0	0	0.012319	0	21	92									
RAB23	51715	broad.mit.edu	37	6	57075078	57075078	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:57075078A>C	uc003pds.2	-	2	307	c.101T>G	c.(100-102)TTT>TGT	p.F34C	RAB23_uc003pdt.2_Missense_Mutation_p.F34C|RAB23_uc010kac.2_Missense_Mutation_p.F34C|RAB23_uc010kad.2_RNA	NM_183227	NP_899050	Q9ULC3	RAB23_HUMAN	Ras-related protein Rab-23	34					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			skin(1)	1	Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			GTCTTTTGTAAAAATGCCTTT	0.373		NaN											0	0	0	0.006999	0	42	137									
PRIM2	5558	broad.mit.edu	37	6	57183276	57183276	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:57183276G>A	uc003pdx.2	+	2	120	c.33G>A	c.(31-33)CTG>CTA	p.L11L	PRIM2_uc003pdv.1_Silent_p.L11L|PRIM2_uc003pdw.2_Silent_p.L11L	NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	11					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		GGAGGAAGCTGAGGTTGGCAG	0.403		NaN											0	0	0	0.006214	0	9	16									
COL19A1	1310	broad.mit.edu	37	6	70875842	70875842	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:70875842G>A	uc003pfc.1	+	37	2527	c.2410G>A	c.(2410-2412)GGA>AGA	p.G804R	COL19A1_uc010kam.1_Missense_Mutation_p.G700R	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	804	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGGCAGCGACGGACCCCCTGG	0.443		NaN											0	0	0	0.007291	0	28	171									
COL9A1	1297	broad.mit.edu	37	6	70966509	70966509	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:70966509C>T	uc003pfg.3	-	21	1624	c.1465G>A	c.(1465-1467)GAT>AAT	p.D489N	COL9A1_uc003pfe.3_Missense_Mutation_p.D62N|COL9A1_uc003pff.3_Missense_Mutation_p.D246N	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	489	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GGTTCACCATCTAAGCCCCGA	0.383		NaN											0	0	0	0.009096	0	3	33									
RIMS1	22999	broad.mit.edu	37	6	72892790	72892790	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:72892790C>T	uc003pga.2	+	6	1693	c.1616C>T	c.(1615-1617)TCG>TTG	p.S539L	RIMS1_uc011dyb.1_Missense_Mutation_p.S165L|RIMS1_uc003pgc.2_Missense_Mutation_p.S165L|RIMS1_uc003pgb.3_Missense_Mutation_p.S165L	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	539					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GAGGGCGTGTCGACGCCCGAG	0.692		NaN											0	0	0	0.004672	0	3	3									
RIMS1	22999	broad.mit.edu	37	6	72968754	72968754	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:72968754G>A	uc003pga.2	+	18	3070	c.2993G>A	c.(2992-2994)CGA>CAA	p.R998Q	RIMS1_uc011dyb.1_Missense_Mutation_p.R623Q|RIMS1_uc003pgc.2_Missense_Mutation_p.R624Q|RIMS1_uc010kaq.2_Missense_Mutation_p.R471Q|RIMS1_uc011dyc.1_Missense_Mutation_p.R472Q|RIMS1_uc010kar.2_Missense_Mutation_p.R391Q|RIMS1_uc011dyd.1_Missense_Mutation_p.R457Q|RIMS1_uc003pgf.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgg.2_Missense_Mutation_p.R215Q|RIMS1_uc003pgi.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgh.2_Missense_Mutation_p.R214Q|RIMS1_uc003pgd.2_Missense_Mutation_p.R215Q|RIMS1_uc003pge.2_Missense_Mutation_p.R215Q|RIMS1_uc011dye.1_5'UTR|RIMS1_uc011dyf.1_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.R624Q|RIMS1_uc010kas.1_Missense_Mutation_p.R457Q	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	998					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GATGCCTCCCGAAGTCCAGTT	0.353		NaN											0	0	0	0.01441	0	53	73									
KCNQ5	56479	broad.mit.edu	37	6	73843259	73843259	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:73843259G>A	uc003pgk.2	+	10	1710	c.1363G>A	c.(1363-1365)GAG>AAG	p.E455K	KCNQ5_uc011dyh.1_Missense_Mutation_p.E474K|KCNQ5_uc011dyi.1_Missense_Mutation_p.E465K|KCNQ5_uc010kat.2_Missense_Mutation_p.E446K|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Missense_Mutation_p.E205K	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	455					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CATCACAGCCGAGGGCAGTCC	0.592		NaN											0	0	0	0.014323	0	22	68									
KCNQ5	56479	broad.mit.edu	37	6	73904551	73904551	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:73904551C>T	uc003pgk.2	+	14	2560	c.2213C>T	c.(2212-2214)ACG>ATG	p.T738M	KCNQ5_uc011dyh.1_Missense_Mutation_p.T757M|KCNQ5_uc011dyi.1_Missense_Mutation_p.T748M|KCNQ5_uc010kat.2_Missense_Mutation_p.T729M|KCNQ5_uc011dyj.1_Missense_Mutation_p.T628M|KCNQ5_uc011dyk.1_Missense_Mutation_p.T488M	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	738					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CAAATAAATACGGCACCCAAG	0.532		NaN											0	0	0	0.014323	0	20	22									
C6orf150	115004	broad.mit.edu	37	6	74150017	74150017	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:74150017C>T	uc003pgx.1	-	3	1168	c.1029G>A	c.(1027-1029)TGG>TGA	p.W343*		NM_138441	NP_612450	Q8N884	M21D1_HUMAN	hypothetical protein LOC115004	343											0						TTGCTGAAAGCCAGTTTTGAA	0.393		NaN											0	0	0	0.01441	0	49	93									
CD109	135228	broad.mit.edu	37	6	74440088	74440088	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:74440088G>A	uc003php.2	+	4	723	c.298G>A	c.(298-300)GAG>AAG	p.E100K	CD109_uc010kaz.2_Missense_Mutation_p.E100K|CD109_uc003phq.2_Missense_Mutation_p.E100K|CD109_uc010kba.2_Intron	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	100						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						CAGTGCAGATGAGATTTATGA	0.373		NaN											0	0	0	0.008361	0	30	135									
SENP6	26054	broad.mit.edu	37	6	76425252	76425252	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:76425252C>G	uc003pid.3	+	24	3900	c.3281C>G	c.(3280-3282)TCA>TGA	p.S1094*	SENP6_uc003pie.3_Nonsense_Mutation_p.S1087*|SENP6_uc010kbf.2_RNA	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	SUMO1/sentrin specific peptidase 6 isoform 1	1094	Protease.				proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|urinary_tract(1)|ovary(1)|lung(1)|skin(1)	6		all_hematologic(105;0.189)				GACACTTACTCAACAGAAGCA	0.363		NaN											0	0	0	0.01441	0	57	80									
IMPG1	3617	broad.mit.edu	37	6	76657219	76657219	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:76657219C>T	uc003pik.1	-	14	1986	c.1856G>A	c.(1855-1857)GGA>GAA	p.G619E		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	619	SEA 2.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTGCTTAAATCCTGTAAGATT	0.393		NaN											0	0	0	0.008291	0	10	22									
LCA5	167691	broad.mit.edu	37	6	80228490	80228490	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:80228490G>A	uc003pix.2	-	2	557	c.122C>T	c.(121-123)TCT>TTT	p.S41F	LCA5_uc003piy.2_Missense_Mutation_p.S41F|LCA5_uc011dyq.1_RNA|LCA5_uc011dyr.1_Missense_Mutation_p.S41F	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	41					protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TGCAGGTGAAGAACTGACCAG	0.423		NaN											0	0	0	0.01441	0	108	200									
CYB5R4	51167	broad.mit.edu	37	6	84618805	84618805	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:84618805G>A	uc003pkf.2	+	4	540	c.408G>A	c.(406-408)CTG>CTA	p.L136L		NM_016230	NP_057314	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	136					cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(2)	2		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		CTGCTGTTCTGAAAGGTAAGT	0.393		NaN											0	0	0	0.006214	0	10	54									
KIAA1009	22832	broad.mit.edu	37	6	84862559	84862559	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:84862559G>A	uc010kbp.2	-	23	3431	c.3334C>T	c.(3334-3336)CAG>TAG	p.Q1112*	KIAA1009_uc003pkj.3_Nonsense_Mutation_p.Q1036*|KIAA1009_uc003pki.3_Nonsense_Mutation_p.Q498*	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	KIAA1009 protein	1112	Potential.				cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			ovary(1)	1		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CTGTCTTTCTGAAGCCTCTCC	0.403		NaN											0	0	0	0.005443	0	28	52									
GABRR1	2569	broad.mit.edu	37	6	89888585	89888585	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:89888585C>G	uc003pna.2	-	10	1799	c.1344G>C	c.(1342-1344)ATG>ATC	p.M448I	GABRR1_uc011dzv.1_Missense_Mutation_p.M425I	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	448	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	TGTCGATTCTCATGCTCACAT	0.463		NaN											0	0	0	0.01441	0	44	173									
MAP3K7	6885	broad.mit.edu	37	6	91257893	91257893	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:91257893G>A	uc003pnz.1	-	10	1115	c.953C>T	c.(952-954)TCA>TTA	p.S318L	MAP3K7_uc003poa.1_Missense_Mutation_p.S318L|MAP3K7_uc003pob.1_Missense_Mutation_p.S318L|MAP3K7_uc003poc.1_Missense_Mutation_p.S318L	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	318					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		GTCCATGAATGAGCCTAGGAA	0.343		NaN											0	0	0	0.006999	0	40	64									
KLHL32	114792	broad.mit.edu	37	6	97587083	97587083	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:97587083C>T	uc010kcm.1	+	11	2260	c.1788C>T	c.(1786-1788)TTC>TTT	p.F596F	KLHL32_uc011ead.1_Silent_p.F560F|KLHL32_uc003poz.2_Silent_p.F152F|KLHL32_uc011eae.1_Silent_p.F527F|KLHL32_uc003ppa.2_RNA	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	596	Kelch 6.									ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CAGCATGCTTCCTTCCAGCTC	0.448		NaN											0	0	0	0.004878	0	38	153									
C6orf167	253714	broad.mit.edu	37	6	97626329	97626329	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:97626329C>G	uc003ppb.2	-	18	2935	c.2669G>C	c.(2668-2670)CGA>CCA	p.R890P	C6orf167_uc011eaf.1_Missense_Mutation_p.R850P	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	890					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CTCAAAGAATCGAACAAGTGC	0.274		NaN											0	0	0	0.00499	0	16	117									
CCNC	892	broad.mit.edu	37	6	99994315	99994315	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:99994315C>G	uc003pqe.2	-	10	921	c.634G>C	c.(634-636)GAT>CAT	p.D212H	uc003pqc.2_Intron|CCNC_uc003pqd.2_Missense_Mutation_p.D127H|CCNC_uc010kcr.2_RNA|CCNC_uc010kcs.2_Missense_Mutation_p.D211H|CCNC_uc011eah.1_Missense_Mutation_p.D127H	NM_005190	NP_005181	P24863	CCNC_HUMAN	cyclin C isoform a	212					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	DNA-directed RNA polymerase II, holoenzyme	protein kinase binding				0		all_cancers(76;8.46e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.064)		TGCCTGGCATCTTTCTGCTGT	0.358		NaN											0	0	0	0.008871	0	17	102									
ATG5	9474	broad.mit.edu	37	6	106649864	106649864	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:106649864G>A	uc003prf.2	-	7	1027	c.674C>T	c.(673-675)TCT>TTT	p.S225F	ATG5_uc010kdb.2_3'UTR|ATG5_uc003prg.2_Missense_Mutation_p.S147F|ATG5_uc010kdc.2_3'UTR	NM_004849	NP_004840	Q9H1Y0	ATG5_HUMAN	APG5 autophagy 5-like	225					apoptosis|autophagic vacuole assembly|negative regulation of type I interferon production|post-translational protein modification	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			large_intestine(1)	1	Breast(9;0.0296)	all_cancers(87;0.000301)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0612)|Lung NSC(302;0.216)	BRCA - Breast invasive adenocarcinoma(8;0.00802)	OV - Ovarian serous cystadenocarcinoma(136;0.128)|Epithelial(106;0.159)|all cancers(137;0.18)		ATCAATAGCAGAAGGACAAAC	0.378		NaN											0	0	0	0.01441	0	53	58									
SESN1	27244	broad.mit.edu	37	6	109415101	109415101	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:109415101G>A	uc003psu.2	-	1	187	c.176C>T	c.(175-177)TCG>TTG	p.S59L	C6orf182_uc003psv.3_5'Flank|C6orf182_uc003psw.3_5'Flank|C6orf182_uc010kdk.2_5'Flank|C6orf182_uc003psx.3_5'Flank|C6orf182_uc010kdl.2_5'Flank	NM_014454	NP_055269	Q9Y6P5	SESN1_HUMAN	sestrin 1	Error:Variant_position_missing_in_Q9Y6P5_after_alignment					cell cycle arrest|negative regulation of cell proliferation|response to DNA damage stimulus	nucleus				ovary(1)	1		all_cancers(87;6.45e-05)|Acute lymphoblastic leukemia(125;3.55e-10)|all_hematologic(75;1.68e-07)|all_epithelial(87;0.0106)|Colorectal(196;0.0637)		Epithelial(106;0.0014)|BRCA - Breast invasive adenocarcinoma(108;0.00146)|all cancers(137;0.0031)|OV - Ovarian serous cystadenocarcinoma(136;0.0117)		CAACCCATCCGAAGACTCGGT	0.423		NaN											0	0	0	0.01441	0	74	110									
CD164	8763	broad.mit.edu	37	6	109700850	109700850	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:109700850C>T	uc003pte.2	-	2	372	c.191G>A	c.(190-192)CGA>CAA	p.R64Q	CD164_uc003ptd.2_Missense_Mutation_p.R64Q|CD164_uc003ptf.2_Missense_Mutation_p.R64Q|CD164_uc011eap.1_Missense_Mutation_p.R64Q|CD164_uc010kdn.2_Missense_Mutation_p.R64Q	NM_006016	NP_006007	Q04900	MUC24_HUMAN	CD164 molecule, sialomucin isoform 1	64	Extracellular (Potential).				hemopoiesis|heterophilic cell-cell adhesion|immune response|muscle organ development|negative regulation of cell adhesion|negative regulation of cell proliferation|signal transduction	endosome membrane|extracellular region|integral to plasma membrane|lysosomal membrane	protein binding				0		all_cancers(87;4.65e-22)|all_epithelial(87;2.54e-20)|all_lung(197;1.6e-05)|Lung NSC(302;2.92e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.0175)		Epithelial(106;7.83e-46)|all cancers(137;1.15e-45)|OV - Ovarian serous cystadenocarcinoma(136;2.89e-26)|BRCA - Breast invasive adenocarcinoma(108;0.00128)|GBM - Glioblastoma multiforme(226;0.16)		GCAGCTGTTTCGACCTTCACA	0.358		NaN											0	0	0	0.01441	0	67	65									
FAM26D	221301	broad.mit.edu	37	6	116879249	116879249	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:116879249G>A	uc003pxa.2	+	4	690	c.391G>A	c.(391-393)GAT>AAT	p.D131N	FAM26D_uc003pwz.2_Missense_Mutation_p.D88N|FAM26D_uc010ked.2_Missense_Mutation_p.D130N	NM_153036	NP_694581	Q5JW98	FA26D_HUMAN	hypothetical protein LOC221301	274						integral to membrane					0		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0458)|OV - Ovarian serous cystadenocarcinoma(136;0.0694)|Epithelial(106;0.222)		GGACTGGAAAGATATTTCAGT	0.453		NaN											0	0	0	0.01441	0	54	101									
FAM162B	221303	broad.mit.edu	37	6	117086385	117086385	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:117086385G>A	uc003pxi.2	-	2	353	c.206C>T	c.(205-207)CCT>CTT	p.P69L		NM_001085480	NP_001078949	Q5T6X4	F162B_HUMAN	hypothetical protein LOC221303	69						integral to membrane					0						GAACTGCGAAGGCCTGCGCTG	0.627		NaN											0	0	0	0.00499	0	16	25									
GPRC6A	222545	broad.mit.edu	37	6	117127788	117127788	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:117127788A>C	uc003pxj.1	-	3	1102	c.1080T>G	c.(1078-1080)CAT>CAG	p.H360Q	GPRC6A_uc003pxk.1_Intron|GPRC6A_uc003pxl.1_Missense_Mutation_p.H360Q	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	360	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		AGGCAGATAAATGCATGGCAT	0.398		NaN											0	0	0	0.003954	0	26	101									
MAN1A1	4121	broad.mit.edu	37	6	119669855	119669855	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:119669855C>T	uc003pym.1	-	2	818	c.376G>A	c.(376-378)GAA>AAA	p.E126K	MAN1A1_uc010kei.1_Missense_Mutation_p.E126K	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	126	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TCGTGGTTTTCGCGGATCCTG	0.507		NaN											0	0	0	0.00333	0	24	41									
NCOA7	135112	broad.mit.edu	37	6	126203598	126203598	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:126203598G>A	uc010kes.2	+	9	1049	c.600G>A	c.(598-600)TTG>TTA	p.L200L	NCOA7_uc003qae.3_Silent_p.L200L|NCOA7_uc003qah.2_Silent_p.L200L|NCOA7_uc003qai.2_Silent_p.L200L|NCOA7_uc010ket.2_Silent_p.L96L|NCOA7_uc003qaf.2_Silent_p.L200L|NCOA7_uc003qag.2_Silent_p.L200L	NM_181782	NP_861447	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7 isoform 1	200					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		GAAAGGCCTTGAAACCCATTG	0.358		NaN											0	0	0	0.006122	0	18	38									
LAMA2	3908	broad.mit.edu	37	6	129796544	129796544	+	Silent	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:129796544A>C	uc003qbn.2	+	52	7554	c.7449A>C	c.(7447-7449)GCA>GCC	p.A2483A	LAMA2_uc003qbo.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2483	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GTATGAAAGCAAGGTAAAATT	0.318		NaN											0	0	0	0.008291	0	10	33									
L3MBTL3	84456	broad.mit.edu	37	6	130376350	130376350	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:130376350C>T	uc003qbt.2	+	8	787	c.617C>T	c.(616-618)TCG>TTG	p.S206L	L3MBTL3_uc003qbu.2_Missense_Mutation_p.S181L	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	206					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		CTGAGGGGTTCGCAGAGAGCA	0.383		NaN											0	0	0	0.006214	0	7	64									
BCLAF1	9774	broad.mit.edu	37	6	136596991	136596991	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:136596991C>T	uc003qgx.1	-	5	1925	c.1672G>A	c.(1672-1674)GAT>AAT	p.D558N	BCLAF1_uc003qgw.1_Missense_Mutation_p.D385N|BCLAF1_uc003qgy.1_Missense_Mutation_p.D556N|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.D556N	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	558					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTGTTAGAATCATCAAGAGGA	0.383		NaN											0	0	0	0.01441	0	71	169									
MAP3K5	4217	broad.mit.edu	37	6	137017141	137017141	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:137017141C>G	uc003qhc.2	-	6	1391	c.1030G>C	c.(1030-1032)GAT>CAT	p.D344H	MAP3K5_uc011edk.1_Missense_Mutation_p.D189H|MAP3K5_uc010kgw.1_Missense_Mutation_p.D344H	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	344					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		GAGGCCAAATCAAAGGTTGGC	0.358		NaN											0	0	0	0.007835	0	37	65									
CCDC28A	25901	broad.mit.edu	37	6	139094917	139094917	+	Missense_Mutation	SNP	G	G	A	rs34991012	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:139094917G>A	uc003qie.2	+	1	261	c.106G>A	c.(106-108)GAG>AAG	p.E36K	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	36											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		TAAACAAACGGAGCTGCGGAG	0.657		NaN											0	0	0	0.003271	0	29	138									
CCDC28A	25901	broad.mit.edu	37	6	139094928	139094928	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:139094928G>A	uc003qie.2	+	1	272	c.117G>A	c.(115-117)AGG>AGA	p.R39R	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	39											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		AGCTGCGGAGGAGCGGGTCCC	0.647		NaN											0	0	0	0.009535	0	23	131									
CITED2	10370	broad.mit.edu	37	6	139694349	139694349	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:139694349C>T	uc003qip.1	-	2	977	c.733G>A	c.(733-735)GAA>AAA	p.E245K		NM_006079	NP_006070	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with	245	Asp/Glu-rich (acidic).			Missing: Inhibits transactivation activity.	adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity				0	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		AGCCAGAGTTCGGGCAGCTCC	0.512		NaN											0	0	0	0.003755	0	36	121									
UTRN	7402	broad.mit.edu	37	6	144759888	144759888	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:144759888G>A	uc003qkt.2	+	11	1341	c.1249G>A	c.(1249-1251)GAT>AAT	p.D417N	UTRN_uc010khq.1_Missense_Mutation_p.D417N	NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	417	Interaction with SYNM.|Spectrin 2.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CAGGCTGCACGATGTGCTGAT	0.517		NaN											0	0	0	0.009535	0	30	79									
UTRN	7402	broad.mit.edu	37	6	144820495	144820495	+	Missense_Mutation	SNP	G	G	A	rs142782123		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:144820495G>A	uc003qkt.2	+	33	4788	c.4696G>A	c.(4696-4698)GAA>AAA	p.E1566K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1566	Interaction with SYNM.|Spectrin 11.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TACTGAAACTGAATTGGTACA	0.448		NaN											0	0	0	0.003954	0	26	41									
UTRN	7402	broad.mit.edu	37	6	145160371	145160371	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:145160371G>A	uc003qkt.2	+	71	10220	c.10128G>A	c.(10126-10128)CTG>CTA	p.L3376L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	3376					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		ATTCTGCACTGAGCTACTCGC	0.537		NaN											0	0	0	0.008361	0	28	60									
SASH1	23328	broad.mit.edu	37	6	148855934	148855934	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:148855934C>G	uc003qme.1	+	16	2467	c.1992C>G	c.(1990-1992)ACC>ACG	p.T664T	SASH1_uc011eeb.1_Silent_p.T425T|SASH1_uc003qmf.1_Silent_p.T74T	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	664	SAM 1.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ATTTGGACACCTTTAAGCTGC	0.488		NaN											0	0	0	0.01441	0	71	86									
TAB2	23118	broad.mit.edu	37	6	149700055	149700055	+	Missense_Mutation	SNP	G	G	C	rs1053435		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:149700055G>C	uc003qmj.2	+	3	1182	c.1004G>C	c.(1003-1005)AGA>ACA	p.R335T	TAB2_uc011eec.1_Missense_Mutation_p.R303T|TAB2_uc010kia.1_Missense_Mutation_p.R335T|TAB2_uc010kib.1_Missense_Mutation_p.R335T|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	335					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						CCCCCACAAAGAAATAATTCT	0.418		NaN											0	0	0	0.012213	0	31	48									
RMND1	55005	broad.mit.edu	37	6	151754317	151754318	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:151754317_151754318CC>AA	uc003qoi.2	-	4	841_842	c.661_662GG>TT	c.(661-663)GGT>TTT	p.G221F	RMND1_uc011eeq.1_Missense_Mutation_p.G10F	NM_017909	NP_060379	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog	221											0		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		TCCAGGATCACCTTCTTTTGCA	0.381		NaN											0	0	0	0.004672	0	13	58									
SYNE1	23345	broad.mit.edu	37	6	152831425	152831425	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:152831425C>T	uc010kiw.2	-	8	1086	c.484G>A	c.(484-486)GAG>AAG	p.E162K	SYNE1_uc003qot.3_Missense_Mutation_p.E169K|SYNE1_uc003qou.3_Missense_Mutation_p.E162K|SYNE1_uc010kjb.1_Missense_Mutation_p.E162K|SYNE1_uc003qpa.1_Missense_Mutation_p.E162K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	162	Actin-binding.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGGGAGTCTCAGAGCTAACT	0.498		NaN								HNSCC(10;0.0054)			0	0	0	0.01441	0	63	84									
RBM16	22828	broad.mit.edu	37	6	155129288	155129288	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:155129288C>T	uc003qqa.2	+	11	1298	c.1066C>T	c.(1066-1068)CTT>TTT	p.L356F	RBM16_uc011efj.1_Missense_Mutation_p.L422F|RBM16_uc011efk.1_Missense_Mutation_p.L401F|RBM16_uc003qpz.2_Missense_Mutation_p.L356F|RBM16_uc010kji.2_Missense_Mutation_p.L377F	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	356	Gln-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		GCAGCATTTTCTTGAACCTGA	0.388		NaN											0	0	0	0.003954	0	25	98									
RBM16	22828	broad.mit.edu	37	6	155143463	155143463	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:155143463C>T	uc003qqa.2	+	17	2078	c.1846C>T	c.(1846-1848)CAG>TAG	p.Q616*	RBM16_uc011efj.1_Nonsense_Mutation_p.Q682*|RBM16_uc011efk.1_Nonsense_Mutation_p.Q661*|RBM16_uc003qpz.2_Nonsense_Mutation_p.Q616*|RBM16_uc010kji.2_Nonsense_Mutation_p.Q637*	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	616					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		CCAGACAACTCAGAGCCCAAC	0.448		NaN											0	0	0	0.01441	0	62	120									
TULP4	56995	broad.mit.edu	37	6	158924726	158924726	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:158924726G>A	uc003qrf.2	+	13	5388	c.4031G>A	c.(4030-4032)CGA>CAA	p.R1344Q	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	1344					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CTGGACAGCCGAGCAGAAGAA	0.537		NaN											0	0	0	0.004482	0	9	47									
TMEM181	57583	broad.mit.edu	37	6	159052907	159052907	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159052907C>T	uc003qrm.3	+	17	1837	c.1826C>T	c.(1825-1827)TCA>TTA	p.S609L		NM_020823	NP_065874	Q9P2C4	TM181_HUMAN	G protein-coupled receptor 178	609					pathogenesis	integral to membrane	toxin binding			ovary(2)|central_nervous_system(1)	3		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;8.15e-18)|BRCA - Breast invasive adenocarcinoma(81;1.38e-05)		AAGGAGGAGTCAGATAGTGAC	0.557		NaN											0	0	0	0.004672	0	3	4									
SYTL3	94120	broad.mit.edu	37	6	159173048	159173048	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159173048C>T	uc003qrp.2	+	12	1367	c.1123C>T	c.(1123-1125)CAG>TAG	p.Q375*	SYTL3_uc011efp.1_Nonsense_Mutation_p.Q375*|SYTL3_uc003qro.2_Nonsense_Mutation_p.Q307*|SYTL3_uc003qrq.2_Nonsense_Mutation_p.Q307*|SYTL3_uc003qrr.2_Nonsense_Mutation_p.Q375*|SYTL3_uc003qrs.2_Nonsense_Mutation_p.Q307*|SYTL3_uc011efq.1_Nonsense_Mutation_p.Q101*	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	375	C2 1.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		CCCGACCTTTCAGGAGACCTT	0.577		NaN											0	0	0	0.000602	0	5	29									
EZR	7430	broad.mit.edu	37	6	159204664	159204664	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159204664G>A	uc003qrt.3	-	6	801	c.586C>T	c.(586-588)CAG>TAG	p.Q196*	EZR_uc011efs.1_Nonsense_Mutation_p.Q164*|EZR_uc003qru.3_Nonsense_Mutation_p.Q196*	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	196	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TCCAGGTCCTGAGCAATCTTC	0.393		NaN											0	0	0	0.004656	0	28	106									
FNDC1	84624	broad.mit.edu	37	6	159677592	159677592	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159677592C>T	uc010kjv.2	+	18	5303	c.5103C>T	c.(5101-5103)ATC>ATT	p.I1701I		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1701	Fibronectin type-III 5.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AAGACTTCATCAGGAACAAGT	0.423		NaN											0	0	0	0.01441	0	62	173									
FNDC1	84624	broad.mit.edu	37	6	159677606	159677606	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:159677606C>G	uc010kjv.2	+	18	5317	c.5117C>G	c.(5116-5118)TCC>TGC	p.S1706C		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1706	Fibronectin type-III 5.					extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AACAAGTGGTCCACTCAAGCT	0.433		NaN											0	0	0	0.01441	0	65	168									
IGF2R	3482	broad.mit.edu	37	6	160500612	160500612	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:160500612G>C	uc003qta.2	+	38	5627	c.5479G>C	c.(5479-5481)GTG>CTG	p.V1827L		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1827	13.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		TTTTGTCCAGGTGACTCGCGA	0.577		NaN											0	0	0	0.004672	0	3	11									
LPA	4018	broad.mit.edu	37	6	160998217	160998217	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:160998217A>G	uc003qtl.2	-	29	4702	c.4582T>C	c.(4582-4584)TCT>CCT	p.S1528P		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4036	Kringle 36.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GGTATCATAGATGACCAAGAT	0.463		NaN											0	0	0	0.004878	0	37	144									
MLLT4	4301	broad.mit.edu	37	6	168352586	168352586	+	Silent	SNP	C	C	T	rs141139097		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:168352586C>T	uc003qwd.2	+	29	4670	c.4528C>T	c.(4528-4530)CTG>TTG	p.L1510L	MLLT4_uc003qwb.1_Silent_p.L1495L|MLLT4_uc003qwc.1_Silent_p.L1511L|MLLT4_uc003qwg.1_Silent_p.L820L	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1511					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GGGGGACAGTCTGTCCCCCGA	0.602		NaN	T	MLL	AL								0	0	0	0.004656	0	24	29									
THBS2	7058	broad.mit.edu	37	6	169629759	169629759	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:169629759G>C	uc003qwt.2	-	15	2415	c.2167C>G	c.(2167-2169)CTG>GTG	p.L723V		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	723	TSP type-3 1.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GAATTTGGCAGATGGGGGCAG	0.483		NaN											0	0	0	0.00278	0	22	97									
CARD11	84433	broad.mit.edu	37	7	2966391	2966391	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:2966391C>T	uc003smv.2	-	14	2193	c.1789G>A	c.(1789-1791)GAC>AAC	p.D597N		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	597					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TCTAAGGCGTCAAACCCGCCG	0.577		NaN	Mis		DLBCL								0	0	0	0.009096	0	4	11									
CARD11	84433	broad.mit.edu	37	7	2966418	2966418	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:2966418C>T	uc003smv.2	-	14	2166	c.1762G>A	c.(1762-1764)GAA>AAA	p.E588K		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	588					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTGTCTTCTTCGACTGTGCTG	0.567		NaN	Mis		DLBCL								0	0	0	0.001168	0	5	12									
RNF216	54476	broad.mit.edu	37	7	5780687	5780687	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:5780687G>C	uc003soy.1	-	4	980	c.790C>G	c.(790-792)CAA>GAA	p.Q264E	RNF216_uc010ksz.1_5'UTR|RNF216_uc010kta.1_Intron|RNF216_uc011jwj.1_Intron|RNF216_uc003sox.1_Missense_Mutation_p.Q321E	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	264					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TTGGGCTCTTGAGATTCTTGC	0.453		NaN											0	0	0	0.012213	0	32	108									
ARL4A	10124	broad.mit.edu	37	7	12728246	12728246	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:12728246G>A	uc003ssp.2	+	2	644	c.367G>A	c.(367-369)GAA>AAA	p.E123K	ARL4A_uc003ssq.2_Missense_Mutation_p.E123K|ARL4A_uc003ssr.2_Missense_Mutation_p.E123K|ARL4A_uc003sss.2_Missense_Mutation_p.E123K	NM_001037164	NP_001032241	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	123					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		TAGGATATCAGAAAATCAGGG	0.378		NaN											0	0	0	0.013537	0	11	78									
ETV1	2115	broad.mit.edu	37	7	13975376	13975376	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:13975376G>C	uc011jxq.1	-	8	1250	c.511C>G	c.(511-513)CCA>GCA	p.P171A	ETV1_uc011jxn.1_Missense_Mutation_p.P131A|ETV1_uc011jxo.1_Intron|ETV1_uc011jxp.1_Missense_Mutation_p.P113A|ETV1_uc003ssw.3_Missense_Mutation_p.P171A|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Missense_Mutation_p.P153A|ETV1_uc011jxs.1_Missense_Mutation_p.P153A|ETV1_uc010ktv.2_Missense_Mutation_p.P40A	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	171					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						GACTGCGATGGAGGGAGGTGA	0.512		NaN	T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								0	0	0	0.009535	0	30	176									
TMEM195	392636	broad.mit.edu	37	7	15601351	15601351	+	Silent	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:15601351T>C	uc003stb.1	-	1	290	c.120A>G	c.(118-120)GTA>GTG	p.V40V		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	40					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						TCACCTTTTTTACATAATCAG	0.373		NaN											0	0	0	0.003271	0	30	127									
AGR2	10551	broad.mit.edu	37	7	16840963	16840963	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:16840963G>A	uc003str.2	-	3	371	c.184C>T	c.(184-186)CTA>TTA	p.L62L	AGR2_uc011jxy.1_3'UTR	NM_006408	NP_006399	O95994	AGR2_HUMAN	anterior gradient 2 homolog precursor	62					mucus secretion	endoplasmic reticulum|extracellular region	protein binding				0	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		GATTTATATAGAGCTTCTTCA	0.388		NaN											0	0	0	0.00245	0	14	55									
HDAC9	9734	broad.mit.edu	37	7	18705862	18705862	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:18705862G>A	uc003suh.2	+	11	1526	c.1485G>A	c.(1483-1485)CTG>CTA	p.L495L	HDAC9_uc003sue.2_Silent_p.L495L|HDAC9_uc011jyd.1_Silent_p.L495L|HDAC9_uc003sui.2_Silent_p.L498L|HDAC9_uc003suj.2_Silent_p.L454L|HDAC9_uc011jya.1_Silent_p.L492L|HDAC9_uc003sua.1_Silent_p.L473L|HDAC9_uc011jyb.1_Silent_p.L451L|HDAC9_uc003sud.1_Silent_p.L495L|HDAC9_uc011jyc.1_Silent_p.L454L|HDAC9_uc003suf.1_Silent_p.L526L|HDAC9_uc010kud.1_Silent_p.L498L|HDAC9_uc011jye.1_Silent_p.L467L|HDAC9_uc011jyf.1_Silent_p.L418L|HDAC9_uc010kue.1_Intron	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	495					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TTGAACAACTGAAGCAACCAG	0.473		NaN									OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004289	0	36	133									
NUPL2	11097	broad.mit.edu	37	7	23240239	23240239	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:23240239G>C	uc003svu.2	+	7	1406	c.1147G>C	c.(1147-1149)GAT>CAT	p.D383H	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_Missense_Mutation_p.D260H|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_Missense_Mutation_p.D260H|NUPL2_uc011jyx.1_Missense_Mutation_p.D155H	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	383	Interaction with GLE1.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						CATTGCAACAGATAATGTGTT	0.393		NaN											0	0	0	0.00632	0	28	174									
C7orf41	222166	broad.mit.edu	37	7	30174846	30174846	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:30174846G>A	uc011kab.1	+	1	295	c.94G>A	c.(94-96)GAT>AAT	p.D32N	C7orf41_uc010kvr.1_RNA|C7orf41_uc003tar.1_Missense_Mutation_p.D32N	NM_152793	NP_690006	Q8N3F0	CG041_HUMAN	hypothetical protein LOC222166	32											0						ACGCAGGATGGATTTCTACGC	0.597		NaN											0	0	0	0.004672	0	3	13									
EEPD1	80820	broad.mit.edu	37	7	36327382	36327382	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:36327382G>A	uc003tfa.2	+	6	1951	c.1311G>A	c.(1309-1311)CTG>CTA	p.L437L		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	437					DNA repair		DNA binding				0						AGGAAACCCTGAAAGGTAGGA	0.567		NaN											0	0	0	0.01441	0	44	78									
PSMA2	5683	broad.mit.edu	37	7	42964297	42964297	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:42964297C>T	uc003thy.2	-	4	399	c.351G>A	c.(349-351)GTG>GTA	p.V117V	C7orf25_uc010kxr.2_5'UTR|PSMA2_uc010kxt.2_Silent_p.V39V|PSMA2_uc003thz.1_Silent_p.V39V	NM_002787	NP_002778	P25787	PSA2_HUMAN	proteasome subunit alpha type 2	117					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|response to virus|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	protein binding|threonine-type endopeptidase activity			large_intestine(2)|ovary(1)	3						ATTCTTGCATCACAGAAGCTA	0.393		NaN											0	0	0	0.005443	0	27	131									
HECW1	23072	broad.mit.edu	37	7	43540819	43540819	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:43540819G>A	uc003tid.1	+	21	4134	c.3529G>A	c.(3529-3531)GAA>AAA	p.E1177K	HECW1_uc011kbi.1_Missense_Mutation_p.E1143K	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1177					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CAGTCTCTTTGAAGAAGAGAT	0.423		NaN											0	0	0	0.001855	0	14	63									
NPC1L1	29881	broad.mit.edu	37	7	44573037	44573037	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:44573037C>T	uc003tlb.2	-	8	2458	c.2402G>A	c.(2401-2403)AGG>AAG	p.R801K	NPC1L1_uc003tlc.2_Missense_Mutation_p.R801K|NPC1L1_uc011kbw.1_Missense_Mutation_p.R801K|NPC1L1_uc003tld.2_3'UTR	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	801	Cytoplasmic (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	TACCTCCTGCCTCTTGCTGTC	0.622		NaN											0	0	0	0.007291	0	29	40									
COBL	23242	broad.mit.edu	37	7	51095844	51095844	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:51095844C>T	uc003tpr.3	-	10	3134	c.2949G>A	c.(2947-2949)CAG>CAA	p.Q983Q	COBL_uc003tps.2_Silent_p.Q1040Q|COBL_uc011kcl.1_Silent_p.Q983Q|COBL_uc003tpp.3_Silent_p.Q769Q|COBL_uc003tpq.3_Silent_p.Q924Q|COBL_uc003tpo.3_Silent_p.Q525Q	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	983										skin(3)|ovary(2)	5	Glioma(55;0.08)					CACGATCCCTCTGGGAAGACT	0.557		NaN											0	0	0	0.004007	0	16	62									
VSTM2A	222008	broad.mit.edu	37	7	54612455	54612455	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:54612455C>T	uc010kzf.2	+	2	625	c.220C>T	c.(220-222)CCC>TCC	p.P74S	VSTM2A_uc010kze.2_Missense_Mutation_p.P74S|VSTM2A_uc003tqc.3_Missense_Mutation_p.P74S	NM_182546	NP_872352	Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2	74	Ig-like V-type.					extracellular region					0			STAD - Stomach adenocarcinoma(5;0.0525)			GGACCTGGATCCCGGGGCCGA	0.736		NaN											0	0	0	0.001984	0	7	14									
SUMF2	25870	broad.mit.edu	37	7	56141885	56141885	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:56141885C>T	uc003trv.2	+	4	446	c.415C>T	c.(415-417)CCA>TCA	p.P139S	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Missense_Mutation_p.P139S|SUMF2_uc011kcx.1_Missense_Mutation_p.P139S|SUMF2_uc003trt.2_Missense_Mutation_p.P32S|SUMF2_uc011kcy.1_Intron|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_Intron|SUMF2_uc003trx.2_Intron	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	120						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTGGTGGCTTCCAGTGGAAAA	0.552		NaN									OREG0018081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.011902	0	41	164									
SUMF2	25870	broad.mit.edu	37	7	56141899	56141899	+	Silent	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:56141899A>G	uc003trv.2	+	4	460	c.429A>G	c.(427-429)GCA>GCG	p.A143A	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Silent_p.A143A|SUMF2_uc011kcx.1_Silent_p.A143A|SUMF2_uc003trt.2_Silent_p.A36A|SUMF2_uc011kcy.1_Intron|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_RNA|SUMF2_uc011kda.1_Intron|SUMF2_uc003trx.2_Intron	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	124						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGGAAAAGGCATTTTGGAGGC	0.552		NaN									OREG0018081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006999	0	37	156									
SUMF2	25870	broad.mit.edu	37	7	56142308	56142308	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:56142308G>A	uc003trv.2	+	5	502	c.471G>A	c.(469-471)GAG>GAA	p.E157E	PSPH_uc003trj.2_Intron|SUMF2_uc011kcv.1_RNA|SUMF2_uc011kcw.1_Silent_p.E157E|SUMF2_uc011kcx.1_Intron|SUMF2_uc003trt.2_Silent_p.E50E|SUMF2_uc011kcy.1_Silent_p.E142E|SUMF2_uc011kcz.1_Intron|SUMF2_uc003tru.2_Intron|SUMF2_uc011kda.1_Intron|SUMF2_uc003trx.2_Intron	NM_001130069	NP_001123541	Q8NBJ7	SUMF2_HUMAN	sulfatase modifying factor 2 isoform e	138						endoplasmic reticulum lumen	metal ion binding			ovary(1)|skin(1)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GCATCCGAGAGAGACTGGAGC	0.597		NaN									OREG0018081	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	14	96									
ASL	435	broad.mit.edu	37	7	65554627	65554627	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:65554627C>G	uc003tuo.2	+	14	1118	c.1007C>G	c.(1006-1008)TCA>TGA	p.S336*	ASL_uc003tup.2_Nonsense_Mutation_p.S336*|ASL_uc003tur.2_Nonsense_Mutation_p.S310*|ASL_uc003tuq.2_Nonsense_Mutation_p.S316*	NM_000048	NP_000039	P04424	ARLY_HUMAN	argininosuccinate lyase isoform 1	336					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)	TTTGAAGTGTCAGACACTATG	0.642		NaN											0	0	0	0.003163	0	14	53									
SBDS	51119	broad.mit.edu	37	7	66456253	66456253	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:66456253C>T	uc003tvm.1	-	4	679	c.495G>A	c.(493-495)ATG>ATA	p.M165I		NM_016038	NP_057122	Q9Y3A5	SBDS_HUMAN	Shwachman-Bodian-Diamond syndrome protein	165					bone marrow development|bone mineralization|leukocyte chemotaxis|mature ribosome assembly|mitotic spindle stabilization|positive regulation of translation|ribosomal large subunit biogenesis|rRNA processing	cytoplasm|nucleolus|nucleoplasm|spindle pole	microtubule binding|ribosome binding|rRNA binding			ovary(1)	1						GTTCTATCTTCATTTTCTCTT	0.368		NaN	Gene Conversion			AML|MDS			Shwachman-Diamond_syndrome				0	0	0	0.00632	0	25	55									
STAG3L4	64940	broad.mit.edu	37	7	66771042	66771042	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:66771042C>G	uc003tvt.3	+	2	326	c.59C>G	c.(58-60)ACT>AGT	p.T20S	STAG3L4_uc010laj.2_RNA	NM_022906	NP_075057	Q8TBR4	STG34_HUMAN	stromal antigen 3-like 4	20											0		Lung NSC(55;0.0839)|all_lung(88;0.181)				AGCTTGTTAACTTTTTCATCT	0.368		NaN											0	0	0	0.009718	0	40	201									
WBSCR22	114049	broad.mit.edu	37	7	73107716	73107716	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:73107716G>T	uc003tyt.2	+	8	626	c.568G>T	c.(568-570)GAC>TAC	p.D190Y	WBSCR22_uc010lbi.1_RNA|WBSCR22_uc003tyu.2_Missense_Mutation_p.D190Y|WBSCR22_uc003tyv.2_Missense_Mutation_p.D152Y|WBSCR22_uc003tyw.1_Missense_Mutation_p.D53Y	NM_017528	NP_059998	O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	190						nucleus	methyltransferase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				CATGGTGGTAGACTACCCTAA	0.602		NaN											1	0	0.00198382	0.001984	0.00201257	7	12									
TMEM120A	83862	broad.mit.edu	37	7	75617097	75617097	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:75617097C>G	uc003ued.2	-	10	827	c.723G>C	c.(721-723)CAG>CAC	p.Q241H	TMEM120A_uc003uee.2_Missense_Mutation_p.E180Q|TMEM120A_uc003ueb.1_Missense_Mutation_p.Q27H|TMEM120A_uc003uec.2_Missense_Mutation_p.Q145H	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	transmembrane protein 120A	241	Cytoplasmic (Potential).					integral to membrane					0						GGCAGCCGCTCTGGTAGTAGT	0.687		NaN											0	0	0	0.009096	0	3	8									
PTPN12	5782	broad.mit.edu	37	7	77247848	77247848	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:77247848G>A	uc003ugh.2	+	12	1082	c.991G>A	c.(991-993)GAT>AAT	p.D331N	PTPN12_uc011kgp.1_Missense_Mutation_p.D212N|PTPN12_uc011kgq.1_Missense_Mutation_p.D201N|PTPN12_uc010lds.2_Missense_Mutation_p.D63N	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	331						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						TGAAAAACAAGATTCTCCTCC	0.348		NaN											0	0	0	0.003271	0	34	99									
PHTF2	57157	broad.mit.edu	37	7	77539723	77539723	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:77539723C>G	uc003ugs.3	+	8	899	c.773C>G	c.(772-774)TCA>TGA	p.S258*	PHTF2_uc003ugo.3_Nonsense_Mutation_p.S220*|PHTF2_uc003ugp.2_Nonsense_Mutation_p.S220*|PHTF2_uc003ugq.3_Nonsense_Mutation_p.S220*|PHTF2_uc010ldv.2_Nonsense_Mutation_p.S220*|PHTF2_uc003ugr.3_Nonsense_Mutation_p.S224*|PHTF2_uc003ugt.3_Nonsense_Mutation_p.S224*|PHTF2_uc003ugu.3_Nonsense_Mutation_p.S220*|PHTF2_uc003ugv.2_Nonsense_Mutation_p.S83*|PHTF2_uc010ldw.1_Nonsense_Mutation_p.S83*	NM_001127357	NP_001120829	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			ovary(1)	1						TTCTTTTTATCAGGGTTTGTA	0.398		NaN											0	0	0	0.006122	0	17	21									
MAGI2	9863	broad.mit.edu	37	7	78130895	78130895	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:78130895C>G	uc003ugx.2	-	5	1218	c.964G>C	c.(964-966)GAC>CAC	p.D322H	MAGI2_uc003ugy.2_Missense_Mutation_p.D322H|MAGI2_uc011kgr.1_Missense_Mutation_p.D154H|MAGI2_uc011kgs.1_Missense_Mutation_p.D159H	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	322	WW 1.|Interaction with DDN.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GAAACTCACTCAATGAAGTAG	0.383		NaN											0	0	0	0.006122	0	17	74									
PCLO	27445	broad.mit.edu	37	7	82582282	82582282	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:82582282G>C	uc003uhx.2	-	5	8276	c.7987C>G	c.(7987-7989)CCC>GCC	p.P2663A	PCLO_uc003uhv.2_Missense_Mutation_p.P2663A|PCLO_uc010lec.2_5'Flank	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	2594					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACTGATGTGGGAGCTGCTTGA	0.443		NaN											0	0	0	0.00874	0	35	24									
SEMA3D	223117	broad.mit.edu	37	7	84702367	84702367	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:84702367G>A	uc003uic.2	-	4	446	c.406C>T	c.(406-408)CAG>TAG	p.Q136*	SEMA3D_uc010led.2_Nonsense_Mutation_p.Q136*|SEMA3D_uc010lee.1_Nonsense_Mutation_p.Q136*	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	136	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TTATAGGGCTGAAGTACTCTG	0.348		NaN											0	0	0	0.012319	0	20	61									
STEAP4	79689	broad.mit.edu	37	7	87912268	87912268	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:87912268G>C	uc003ujs.2	-	3	777	c.672C>G	c.(670-672)ATC>ATG	p.I224M	STEAP4_uc010lek.2_Intron|STEAP4_uc003ujt.2_Missense_Mutation_p.I224M	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	224					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					CATAAGGGTAGATTACGTCTC	0.383		NaN											0	0	0	0.003163	0	15	75									
STEAP2	261729	broad.mit.edu	37	7	89854699	89854699	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:89854699G>C	uc003ujz.2	+	2	696	c.303G>C	c.(301-303)CTG>CTC	p.L101L	STEAP2_uc003ujy.2_Silent_p.L143L|STEAP2_uc010len.2_Silent_p.L101L|STEAP2_uc003uka.2_Silent_p.L101L|STEAP2_uc003ukb.2_Silent_p.L101L|STEAP2_uc003ukc.2_Silent_p.L101L|STEAP2_uc003ukd.2_Silent_p.L101L	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	101					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					ATACCTCCCTGTGGGACCTGA	0.378		NaN											0	0	0	0.011902	0	45	158									
CDK14	5218	broad.mit.edu	37	7	90528612	90528612	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:90528612G>A	uc003uky.2	+	7	868	c.646G>A	c.(646-648)GAT>AAT	p.D216N	CDK14_uc003ukz.1_Missense_Mutation_p.D198N|CDK14_uc010les.1_Missense_Mutation_p.D170N|CDK14_uc011khl.1_Missense_Mutation_p.D87N	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	216	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						CTAGCACACTGATTTATGTCA	0.363		NaN											0	0	0	0.013537	0	12	31									
FZD1	8321	broad.mit.edu	37	7	90894810	90894810	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:90894810C>T	uc003ula.2	+	1	1028	c.615C>T	c.(613-615)TTC>TTT	p.F205F		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	205	FZ.|Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			TGAACAAGTTCGGCTTCCAGT	0.692		NaN											0	0	0	0.001855	0	13	28									
AKAP9	10142	broad.mit.edu	37	7	91630771	91630771	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:91630771G>A	uc003ulg.2	+	8	1765	c.1540G>A	c.(1540-1542)GAA>AAA	p.E514K	AKAP9_uc003ule.2_Missense_Mutation_p.E526K|AKAP9_uc003ulf.2_Missense_Mutation_p.E514K|AKAP9_uc003uli.2_Missense_Mutation_p.E139K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	526	Glu-rich.|Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAACTCAAGGAAGAACTAGG	0.333		NaN	T	BRAF	papillary thyroid								0	0	0	0.010504	0	21	83									
AKAP9	10142	broad.mit.edu	37	7	91690664	91690664	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:91690664G>A	uc003ulg.2	+	23	5917	c.5692G>A	c.(5692-5694)GAA>AAA	p.E1898K	AKAP9_uc003ulf.2_Missense_Mutation_p.E1898K|AKAP9_uc003uli.2_Missense_Mutation_p.E1521K	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1910	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GTGCCAAGAGGAACTTCGAGA	0.483		NaN	T	BRAF	papillary thyroid								0	0	0	0.004289	0	37	40									
SAMD9L	219285	broad.mit.edu	37	7	92762320	92762320	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:92762320G>A	uc003umh.1	-	5	4181	c.2965C>T	c.(2965-2967)CAC>TAC	p.H989Y	SAMD9L_uc003umj.1_Missense_Mutation_p.H989Y|SAMD9L_uc003umi.1_Missense_Mutation_p.H989Y|SAMD9L_uc010lfb.1_Missense_Mutation_p.H989Y|SAMD9L_uc003umk.1_Missense_Mutation_p.H989Y|SAMD9L_uc010lfc.1_Missense_Mutation_p.H989Y|SAMD9L_uc010lfd.1_Missense_Mutation_p.H989Y|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	989										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			ATCAGAGGGTGAATGATACGC	0.358		NaN											0	0	0	0.007291	0	30	98									
PPP1R9A	55607	broad.mit.edu	37	7	94540505	94540505	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:94540505G>A	uc003unp.2	+	2	1362	c.1080G>A	c.(1078-1080)CAG>CAA	p.Q360Q	PPP1R9A_uc010lfj.2_Silent_p.Q360Q|PPP1R9A_uc011kif.1_Silent_p.Q360Q|PPP1R9A_uc003unq.2_Silent_p.Q360Q|PPP1R9A_uc011kig.1_Silent_p.Q360Q	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	360						cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAAAGCAACAGAGGAAAGAAC	0.438		NaN								HNSCC(28;0.073)			0	0	0	0.012213	0	34	26									
TAC1	6863	broad.mit.edu	37	7	97362008	97362008	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:97362008G>A	uc003uop.3	+	2	330	c.84G>A	c.(82-84)CTG>CTA	p.L28L	TAC1_uc003uoq.3_Silent_p.L28L|TAC1_uc003uor.3_Silent_p.L28L|TAC1_uc003uos.3_Silent_p.L28L	NM_003182	NP_003173	P20366	TKN1_HUMAN	tachykinin 1 isoform beta precursor	28					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space					0	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	ATGATGATCTGAATTACTGGT	0.532		NaN											0	0	0	0.00333	0	25	71									
TRRAP	8295	broad.mit.edu	37	7	98528285	98528285	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:98528285C>T	uc003upp.2	+	25	3632	c.3423C>T	c.(3421-3423)ATC>ATT	p.I1141I	TRRAP_uc011kis.1_Silent_p.I1141I|TRRAP_uc003upr.2_Silent_p.I833I	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1141					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTTCTTACATCGTGGAGCGCC	0.433		NaN											0	0	0	0.01441	0	104	130									
TRRAP	8295	broad.mit.edu	37	7	98581886	98581886	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:98581886A>G	uc003upp.2	+	60	9414	c.9205A>G	c.(9205-9207)ACT>GCT	p.T3069A	TRRAP_uc011kis.1_Missense_Mutation_p.T3040A|TRRAP_uc003upr.2_Missense_Mutation_p.T2757A	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3069	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TACTATTCCAACTGTTCCTAT	0.473		NaN											0	0	0	0.00874	0	38	126									
PTCD1	26024	broad.mit.edu	37	7	99021515	99021515	+	Silent	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:99021515C>A	uc003uqh.2	-	7	1934	c.1803G>T	c.(1801-1803)CTG>CTT	p.L601L	PTCD1_uc011kiw.1_Silent_p.L650L	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	601	PPR 9.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			AGGTGTAGTTCAGCTTCCTGA	0.527		NaN											1	0	7.92952e-12	0.003954	8.28857e-12	26	71									
CPSF4	10898	broad.mit.edu	37	7	99048377	99048377	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:99048377C>T	uc003uqj.2	+	5	599	c.456C>T	c.(454-456)CTC>CTT	p.L152L	PTCD1_uc011kiw.1_Intron|CPSF4_uc003uqi.2_Silent_p.L152L|CPSF4_uc003uqk.2_Silent_p.L152L|CPSF4_uc011kix.1_Silent_p.L99L	NM_006693	NP_006684	O95639	CPSF4_HUMAN	cleavage and polyadenylation specific factor 4,	152	C3H1-type 5.				modification by virus of host mRNA processing|mRNA processing|viral infectious cycle	mRNA cleavage and polyadenylation specificity factor complex	RNA binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGAATTACCTCGTGGGATTCT	0.617		NaN											0	0	0	0.012319	0	20	67									
ZNF655	79027	broad.mit.edu	37	7	99170633	99170633	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:99170633A>C	uc003urh.2	+	3	1295	c.902A>C	c.(901-903)AAA>ACA	p.K301T	ZNF655_uc010lga.2_Missense_Mutation_p.K336T|ZNF655_uc010lgc.2_Missense_Mutation_p.K336T|ZNF655_uc003urj.2_Missense_Mutation_p.K301T|ZNF655_uc003urk.2_Missense_Mutation_p.K138T|ZNF655_uc010lgd.2_Missense_Mutation_p.K138T	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	301					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					ACCAGAGCCAAATCTTACAAA	0.393		NaN											0	0	0	0.014323	0	22	79									
CYP3A7	1551	broad.mit.edu	37	7	99305506	99305506	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:99305506G>C	uc003uru.2	-	12	1450	c.1345C>G	c.(1345-1347)CTC>GTC	p.L449V	ZNF498_uc003urn.2_RNA|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	449					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					ATGTTCACGAGAGCAAACCTC	0.403		NaN											0	0	0	0.01441	0	112	110									
C7orf47	221908	broad.mit.edu	37	7	100033913	100033913	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100033913G>C	uc003uuy.1	-	1	182	c.85C>G	c.(85-87)CAA>GAA	p.Q29E	C7orf47_uc003uux.1_5'UTR	NM_145030	NP_659467	Q8TAP8	CG047_HUMAN	hypothetical protein LOC221908	29	Pro-rich.									ovary(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGCGGGACTTGGGGCTCCGGG	0.677		NaN											0	0	0	0.001168	0	5	11									
LRCH4	4034	broad.mit.edu	37	7	100180050	100180050	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100180050C>T	uc003uvj.2	-	2	306	c.253G>A	c.(253-255)GAG>AAG	p.E85K	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	85	LRR 2.				nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CACGCCGCCTCGGGCACCTCG	0.647		NaN											0	0	0	0.004007	0	16	23									
PCOLCE	5118	broad.mit.edu	37	7	100201832	100201832	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100201832C>T	uc003uvo.2	+	3	653	c.455C>T	c.(454-456)TCG>TTG	p.S152L	uc011kjy.1_5'Flank|PCOLCE_uc011kkb.1_Missense_Mutation_p.S152L|PCOLCE_uc010lhb.1_Intron|PCOLCE_uc003uvp.1_5'Flank	NM_002593	NP_002584	Q15113	PCOC1_HUMAN	procollagen C-endopeptidase enhancer	152					multicellular organismal development	extracellular space	collagen binding|heparin binding|peptidase activator activity				0	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CGGGCCACCTCGGGCACTGGT	0.522		NaN											0	0	0	0.000602	0	4	33									
ZAN	7455	broad.mit.edu	37	7	100391797	100391797	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100391797C>T	uc003uwj.2	+	45	8207	c.8042C>T	c.(8041-8043)TCA>TTA	p.S2681L	ZAN_uc003uwk.2_Intron|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kke.1_Missense_Mutation_p.S629L	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2681	VWFC 5.|Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGTGCCAGCTCACGGATCCTG	0.617		NaN											0	0	0	0.01441	0	49	34									
SRRT	51593	broad.mit.edu	37	7	100478981	100478981	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100478981C>T	uc003uwy.2	+	4	466	c.198C>T	c.(196-198)TTC>TTT	p.F66F	SRRT_uc010lhl.1_Silent_p.F66F|SRRT_uc003uxa.2_Silent_p.F66F|SRRT_uc003uwz.2_Silent_p.F66F	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	66	Arg-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GAGAGCGCTTCTCGCCACCTC	0.597		NaN											0	0	0	0.004656	0	23	34									
SERPINE1	5054	broad.mit.edu	37	7	100773891	100773891	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100773891G>A	uc003uxt.2	+	3	609	c.461G>A	c.(460-462)AGA>AAA	p.R154K	SERPINE1_uc011kkj.1_Missense_Mutation_p.R139K|SERPINE1_uc003uxu.1_5'Flank	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	154					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GAGGTGGAGAGAGCCAGATTC	0.527		NaN											0	0	0	0.01441	0	120	124									
VGF	7425	broad.mit.edu	37	7	100806760	100806760	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:100806760G>A	uc003uxx.3	-	2	1583	c.1365C>T	c.(1363-1365)CTC>CTT	p.L455L		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	455					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					ACAGCTCAATGAGGCTGTCGA	0.463		NaN											0	0	0	0.000602	0	5	10									
MLL5	55904	broad.mit.edu	37	7	104752302	104752302	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:104752302C>G	uc003vcm.2	+	27	4633	c.4099C>G	c.(4099-4101)CAA>GAA	p.Q1367E	MLL5_uc010ljc.2_Missense_Mutation_p.Q1367E|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.Q101E	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1367					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						AATTCCTGCTCAAGCACACGG	0.408		NaN											0	0	0	0.00245	0	13	60									
SRPK2	6733	broad.mit.edu	37	7	104782887	104782887	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:104782887C>T	uc003vct.2	-	10	1265	c.1078G>A	c.(1078-1080)GAA>AAA	p.E360K	SRPK2_uc003vcu.2_Missense_Mutation_p.E360K|SRPK2_uc003vcv.2_Missense_Mutation_p.E371K|SRPK2_uc003vcw.1_Missense_Mutation_p.E360K	NM_182691	NP_872633	P78362	SRPK2_HUMAN	serine/arginine-rich protein-specific kinase 2	360	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TCATCTTTTTCAATGTTTTCT	0.393		NaN											0	0	0	0.012213	0	33	137									
WNT2	7472	broad.mit.edu	37	7	116962989	116962989	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:116962989G>A	uc003viz.2	-	1	355	c.55C>T	c.(55-57)CTC>TTC	p.L19F	WNT2_uc003vja.2_5'UTR	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	19					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TCGGGGGTGAGCCAGGTCAAG	0.607		NaN											0	0	0	0.001168	0	5	25									
C7orf58	79974	broad.mit.edu	37	7	120767150	120767150	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:120767150G>A	uc003vjq.3	+	10	1588	c.1141G>A	c.(1141-1143)GAG>AAG	p.E381K	C7orf58_uc003vjr.1_Missense_Mutation_p.E381K|C7orf58_uc003vjs.3_Missense_Mutation_p.E381K|C7orf58_uc003vjt.3_Missense_Mutation_p.E161K|C7orf58_uc010lkk.1_Missense_Mutation_p.E161K	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	381						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AAAGGTACACGAGCATTTAAA	0.289		NaN											0	0	0	0.00245	0	14	61									
RNF133	168433	broad.mit.edu	37	7	122337916	122337916	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:122337916C>T	uc003vkj.1	-	1	1293	c.1057G>A	c.(1057-1059)GAG>AAG	p.E353K	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	353						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						GGGTTCTCCTCCACATGGATT	0.408		NaN											0	0	0	0.01441	0	61	135									
POT1	25913	broad.mit.edu	37	7	124482960	124482960	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:124482960T>A	uc003vlm.2	-	13	1665	c.1064A>T	c.(1063-1065)AAA>ATA	p.K355I	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.K224I|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	355					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						TTGAGGAGCTTTTTGTTTCAA	0.353		NaN											0	0	0	0.006122	0	19	72									
GCC1	79571	broad.mit.edu	37	7	127224211	127224211	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:127224211C>T	uc003vma.2	-	1	1444	c.1026G>A	c.(1024-1026)ATG>ATA	p.M342I		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	342	Potential.					Golgi membrane|plasma membrane	protein binding			ovary(2)	2						TTACCTTTCTCATTTCCTGCT	0.443		NaN											0	0	0	0.007413	0	15	45									
FAM71F2	346653	broad.mit.edu	37	7	128317717	128317717	+	Silent	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:128317717C>A	uc003vnk.3	+	3	571	c.465C>A	c.(463-465)CTC>CTA	p.L155L	FAM71F2_uc010llm.1_Silent_p.L146L|FAM71F2_uc003vnl.2_RNA|FAM71F2_uc010lln.1_RNA	NM_001012454	NP_001012457	Q6NXP2	F71F2_HUMAN	hypothetical protein LOC346653 isoform a	155											0						ATCTGAAGCTCCACGAAAAAC	0.502		NaN											1	0	1.15919e-05	0.008871	1.18429e-05	17	39									
EXOC4	60412	broad.mit.edu	37	7	132990735	132990735	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:132990735C>T	uc003vrk.2	+	4	611	c.576C>T	c.(574-576)CTC>CTT	p.L192L	EXOC4_uc011kpo.1_Silent_p.L91L|EXOC4_uc003vri.2_Silent_p.L192L|EXOC4_uc003vrj.2_Silent_p.L192L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	192					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				ACTTGGTTCTCATAGATGAAC	0.488		NaN											0	0	0	0.003163	0	15	56									
AKR1B1	231	broad.mit.edu	37	7	134135636	134135636	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:134135636C>T	uc003vrp.1	-	3	327	c.253G>A	c.(253-255)GAG>AAG	p.E85K	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	85					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	AGGCCCTTCTCATGGTACGTG	0.562		NaN											0	0	0	0.00308	0	8	28									
WDR91	29062	broad.mit.edu	37	7	134873230	134873230	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:134873230G>A	uc003vsp.2	-	13	1898	c.1836C>T	c.(1834-1836)TTC>TTT	p.F612F	WDR91_uc010lmq.2_Silent_p.F201F|WDR91_uc010lmr.2_Intron	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	612	WD 5.									breast(2)|ovary(1)|skin(1)	4						CATCATAGCTGAACTCCACAG	0.443		NaN											0	0	0	0.003755	0	33	104									
WDR91	29062	broad.mit.edu	37	7	134873240	134873240	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:134873240G>A	uc003vsp.2	-	13	1888	c.1826C>T	c.(1825-1827)TCT>TTT	p.S609F	WDR91_uc010lmq.2_Missense_Mutation_p.S198F|WDR91_uc010lmr.2_Intron	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	609	WD 5.									breast(2)|ovary(1)|skin(1)	4						GAACTCCACAGAGTAGACCTC	0.483		NaN											0	0	0	0.004878	0	34	110									
CNOT4	4850	broad.mit.edu	37	7	135123034	135123034	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:135123034G>C	uc003vsv.1	-	2	353	c.46C>G	c.(46-48)CTT>GTT	p.L16V	CNOT4_uc003vss.2_Missense_Mutation_p.L16V|CNOT4_uc011kpz.1_Missense_Mutation_p.L16V|CNOT4_uc003vst.2_Missense_Mutation_p.L16V|CNOT4_uc003vsu.1_Missense_Mutation_p.L16V|CNOT4_uc011kpy.1_Missense_Mutation_p.L16V	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	16	RING-type; degenerate.			L->A,E: Abolishes interaction with E2 ubiquitin ligases.	nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						TCCATGCAAAGAGGGCACTCC	0.443		NaN											0	0	0	0.00278	0	24	22									
NUP205	23165	broad.mit.edu	37	7	135329649	135329649	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:135329649C>T	uc003vsw.2	+	40	5597	c.5566C>T	c.(5566-5568)CAG>TAG	p.Q1856*	NUP205_uc003vsx.2_RNA	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1856					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						CTAGTTGTGTCAGTCTGTGAT	0.383		NaN											0	0	0	0.00632	0	29	99									
CHRM2	1129	broad.mit.edu	37	7	136700170	136700170	+	Silent	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:136700170C>G	uc003vtf.1	+	4	1181	c.558C>G	c.(556-558)GTC>GTG	p.V186V	CHRM2_uc003vtg.1_Silent_p.V186V|CHRM2_uc003vtj.1_Silent_p.V186V|CHRM2_uc003vtk.1_Silent_p.V186V|CHRM2_uc003vtl.1_Silent_p.V186V|CHRM2_uc003vtm.1_Silent_p.V186V|CHRM2_uc003vti.1_Silent_p.V186V|CHRM2_uc003vto.1_Silent_p.V186V|CHRM2_uc003vtn.1_Silent_p.V186V|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	186	Helical; Name=5; (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ATGCTGCTGTCACCTTTGGTA	0.488		NaN											0	0	0	0.01441	0	57	60									
DGKI	9162	broad.mit.edu	37	7	137262020	137262020	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:137262020G>C	uc003vtt.2	-	17	1710	c.1709C>G	c.(1708-1710)TCT>TGT	p.S570C	DGKI_uc003vtu.2_Missense_Mutation_p.S270C	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	570					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						TAGGAAGTCAGAAAAAGCTGC	0.328		NaN											0	0	0	0.004672	0	3	26									
LUC7L2	51631	broad.mit.edu	37	7	139083368	139083368	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:139083368G>A	uc003vux.2	+	3	554	c.180G>A	c.(178-180)CTG>CTA	p.L60L	LUC7L2_uc011kqs.1_Silent_p.L57L|LUC7L2_uc011kqt.1_Silent_p.L126L|LUC7L2_uc003vuy.2_Silent_p.L59L|LUC7L2_uc003vuz.1_Silent_p.L7L|LUC7L2_uc003vva.2_Silent_p.L7L	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	60							enzyme binding|metal ion binding				0	Melanoma(164;0.242)					GAGAATGTCTGAAAGTCCATG	0.308		NaN											0	0	0	0.01441	0	49	52									
JHDM1D	80853	broad.mit.edu	37	7	139838913	139838913	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:139838913G>T	uc003vvm.2	-	2	276	c.272C>A	c.(271-273)TCC>TAC	p.S91Y		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	91					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					ACTCAAGGAGGAACCATGTAA	0.358		NaN											1	0	6.03168e-27	0.004878	6.39099e-27	38	98									
RAB19	401409	broad.mit.edu	37	7	140125723	140125723	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:140125723G>C	uc010lni.2	+	4	625	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	RAB19_uc011krc.1_Missense_Mutation_p.E143Q	NM_001008749	NP_001008749	A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	143					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0	Melanoma(164;0.0142)					CGTCCTGTTCGAGGATGCCTG	0.468		NaN											0	0	0	0.010771	0	44	132									
DENND2A	27147	broad.mit.edu	37	7	140301337	140301337	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:140301337G>A	uc010lnj.2	-	1	1006	c.861C>T	c.(859-861)ATC>ATT	p.I287I	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.I287I|DENND2A_uc003vvw.2_Silent_p.I287I|DENND2A_uc003vvx.2_Silent_p.I287I	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	287										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TCCTGAAGCCGATGCCAGGCT	0.378		NaN											0	0	0	0.01441	0	47	105									
EPHB6	2051	broad.mit.edu	37	7	142564247	142564247	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:142564247G>A	uc011kst.1	+	10	2258	c.1471G>A	c.(1471-1473)GTC>ATC	p.V491I	EPHB6_uc011ksu.1_Missense_Mutation_p.V491I|EPHB6_uc003wbs.2_Missense_Mutation_p.V199I|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_Missense_Mutation_p.V199I|EPHB6_uc003wbv.2_5'Flank	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	491	Fibronectin type-III 2.|Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					GCCCTCTGCTGTCCCTGTGGT	0.607		NaN											0	0	0	0.010729	0	11	43									
OR2A5	393046	broad.mit.edu	37	7	143747957	143747957	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:143747957C>T	uc011ktw.1	+	1	463	c.463C>T	c.(463-465)CTG>TTG	p.L155L		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TGGTTCCCTTCTGGCCCTGGT	0.532		NaN											0	0	0	0.01441	0	62	166									
NOBOX	135935	broad.mit.edu	37	7	144101707	144101707	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:144101707G>A	uc011kue.1	-	2	152	c.152C>T	c.(151-153)TCT>TTT	p.S51F		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	51					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					GGAGCTGAAAGAGCCACAGAC	0.463		NaN											0	0	0	0.007413	0	18	71									
ZNF786	136051	broad.mit.edu	37	7	148771522	148771522	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:148771522A>G	uc003wfh.2	-	3	391	c.254T>C	c.(253-255)GTT>GCT	p.V85A	ZNF786_uc011kuk.1_Missense_Mutation_p.V48A|ZNF786_uc003wfi.2_5'UTR	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			ATGCATATCAACAGAGGAGCA	0.428		NaN											0	0	0	0.006214	0	10	40									
AGAP3	116988	broad.mit.edu	37	7	150814758	150814758	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:150814758C>T	uc003wjg.1	+	5	603	c.600C>T	c.(598-600)TTC>TTT	p.F200F	AGAP3_uc003wje.1_5'UTR|AGAP3_uc003wjf.1_Silent_p.F200F|AGAP3_uc010lpy.1_Silent_p.F200F|AGAP3_uc003wjh.1_Silent_p.F380F	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	164	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						TGTTTGTGTTCAGCCTGGAGG	0.552		NaN											0	0	0	0.00623	0	40	129									
GALNT11	63917	broad.mit.edu	37	7	151818704	151818704	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:151818704C>T	uc010lqg.1	+	12	1999	c.1769C>T	c.(1768-1770)TCT>TTT	p.S590F	GALNT11_uc011kvm.1_Missense_Mutation_p.S509F|GALNT11_uc003wku.2_Missense_Mutation_p.S590F	NM_022087	NP_071370	Q8NCW6	GLT11_HUMAN	N-acetylgalactosaminyltransferase 11	590	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		CAGAAGGGCTCTGTCGCCATG	0.517		NaN											0	0	0	0.00499	0	18	41									
RNF32	140545	broad.mit.edu	37	7	156437437	156437437	+	Missense_Mutation	SNP	C	C	G	rs138495614		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:156437437C>G	uc003wmo.2	+	3	442	c.260C>G	c.(259-261)CCG>CGG	p.P87R	RNF32_uc010lql.1_RNA|RNF32_uc010lqm.2_Missense_Mutation_p.P87R|RNF32_uc003wmp.2_Missense_Mutation_p.P87R|RNF32_uc003wmq.2_Missense_Mutation_p.P87R|RNF32_uc003wmr.2_Missense_Mutation_p.P87R|RNF32_uc003wms.2_Missense_Mutation_p.P87R|RNF32_uc003wmu.2_RNA|RNF32_uc003wmt.2_Missense_Mutation_p.P87R	NM_030936	NP_112198	Q9H0A6	RNF32_HUMAN	ring finger protein 32	87						aggresome|endosome	protein binding|zinc ion binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00291)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		CCCAAACCGCCGCCGTTGACT	0.348		NaN											0	0	0	0.003163	0	14	51									
NOM1	64434	broad.mit.edu	37	7	156743173	156743173	+	Missense_Mutation	SNP	G	G	A	rs151324588	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:156743173G>A	uc003wmy.2	+	1	757	c.742G>A	c.(742-744)GAA>AAA	p.E248K		NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	248	Glu-rich.|Necessary for nucleolar localization and for targeting PPP1CA to the nucleolus.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GACACTCCCCGAAAGTGACTT	0.338		NaN											0	0	0	0.003163	0	15	58									
NOM1	64434	broad.mit.edu	37	7	156754887	156754887	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:156754887G>A	uc003wmy.2	+	5	1690	c.1675G>A	c.(1675-1677)GAC>AAC	p.D559N	NOM1_uc010lqp.1_Missense_Mutation_p.D8N	NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	nucleolar protein with MIF4G domain 1	559	MIF4G.				RNA metabolic process	nucleolus	protein binding				0	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		GAAGAACAATGACATGCGCAA	0.438		NaN											0	0	0	0.01441	0	86	102									
DEFA5	1670	broad.mit.edu	37	8	6914118	6914118	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:6914118C>T	uc003wra.1	-	1	142	c.102G>A	c.(100-102)CAG>CAA	p.Q34Q		NM_021010	NP_066290	Q01523	DEF5_HUMAN	defensin, alpha 5 preproprotein	34					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space					0				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CTTCCCCAGACTGCTTCTGGG	0.537		NaN											0	0	0	0.012213	0	33	25									
RP1L1	94137	broad.mit.edu	37	8	10465561	10465561	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:10465561G>A	uc003wtc.2	-	4	6276	c.6047C>T	c.(6046-6048)GCC>GTC	p.A2016V		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	2016					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTCTGGCTGGGCCTCCTCTTC	0.607		NaN											0	0	0	0.004878	0	37	57									
SOX7	83595	broad.mit.edu	37	8	10583400	10583400	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:10583400G>A	uc003wtf.2	-	2	1094	c.1015C>T	c.(1015-1017)CCT>TCT	p.P339S	SOX7_uc011kwz.1_Missense_Mutation_p.P391S	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	339	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGGTGGCCAGGAGTGTTCAAA	0.612		NaN											0	0	0	0.013537	0	12	13									
MTMR7	9108	broad.mit.edu	37	8	17161949	17161949	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:17161949C>T	uc003wxm.2	-	12	1671	c.1432G>A	c.(1432-1434)GAT>AAT	p.D478N	MTMR7_uc003wxn.2_Missense_Mutation_p.D257N|MTMR7_uc011kya.1_Missense_Mutation_p.D112N|MTMR7_uc011kyb.1_Missense_Mutation_p.D69N	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	478	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		TGGCTGTGATCAGCTCTAAAC	0.418		NaN											0	0	0	0.009535	0	30	28									
MTMR7	9108	broad.mit.edu	37	8	17198941	17198941	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:17198941C>A	uc003wxm.2	-	6	902	c.663G>T	c.(661-663)CAG>CAT	p.Q221H	MTMR7_uc003wxn.2_5'UTR	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	221	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		CCTGGAGCATCTGCTCGTCCT	0.572		NaN											1	0	0.00185496	0.001855	0.00188537	14	13									
FGL1	2267	broad.mit.edu	37	8	17722196	17722196	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:17722196C>T	uc003wxx.2	-	9	1168	c.844G>A	c.(844-846)GGG>AGG	p.G282R	FGL1_uc003wxy.2_Missense_Mutation_p.G282R|FGL1_uc003wxz.2_Missense_Mutation_p.G281R|FGL1_uc003wya.2_Missense_Mutation_p.G282R|FGL1_uc003wyb.2_Missense_Mutation_p.G282R|FGL1_uc003wyc.2_Missense_Mutation_p.G282R|FGL1_uc003wyd.2_RNA|FGL1_uc003wye.2_Missense_Mutation_p.G332R|FGL1_uc003wyf.2_Missense_Mutation_p.G252R	NM_201553	NP_963847	Q08830	FGL1_HUMAN	fibrinogen-like 1 precursor	282	Fibrinogen C-terminal.				signal transduction	fibrinogen complex	receptor binding				0				Colorectal(111;0.0573)|COAD - Colon adenocarcinoma(73;0.215)		CAGACAATCCCATTGTCTGTT	0.403		NaN											0	0	0	0.010729	0	11	10									
PSD3	23362	broad.mit.edu	37	8	18725265	18725265	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:18725265G>C	uc003wza.2	-	4	1656	c.1553C>G	c.(1552-1554)TCT>TGT	p.S518C		NM_015310	NP_056125	Q9NYI0	PSD3_HUMAN	ADP-ribosylation factor guanine nucleotide	518					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GACGCCACTAGAATAGCCCAT	0.527		NaN											0	0	0	0.008871	0	21	30									
RHOBTB2	23221	broad.mit.edu	37	8	22864615	22864615	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:22864615C>G	uc003xcq.2	+	5	1394	c.857C>G	c.(856-858)TCC>TGC	p.S286C	RHOBTB2_uc003xcp.2_Missense_Mutation_p.S308C|RHOBTB2_uc011kzp.1_Missense_Mutation_p.S293C|uc003xcr.2_RNA	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	286	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		ATCTACCTCTCCACCTCTTCC	0.657		NaN											0	0	0	0.00632	0	26	23									
PTK2B	2185	broad.mit.edu	37	8	27301724	27301724	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:27301724C>T	uc003xfn.1	+	28	2958	c.2150C>T	c.(2149-2151)CCC>CTC	p.P717L	PTK2B_uc003xfo.1_Missense_Mutation_p.P717L|PTK2B_uc003xfp.1_Missense_Mutation_p.P717L|PTK2B_uc003xfq.1_Missense_Mutation_p.P717L|PTK2B_uc003xfr.1_Missense_Mutation_p.P463L	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	717	Pro-rich.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TCTCTCCAGCCCAGCCGACCT	0.537		NaN											0	0	0	0.006214	0	8	10									
EPHX2	2053	broad.mit.edu	37	8	27361252	27361252	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:27361252C>T	uc003xfu.2	+	3	399	c.318C>T	c.(316-318)CTC>CTT	p.L106L	EPHX2_uc010lut.1_Silent_p.L106L|EPHX2_uc010luu.2_Silent_p.L106L|EPHX2_uc010luv.2_Silent_p.L40L|EPHX2_uc003xfv.2_Silent_p.L53L|EPHX2_uc010luw.2_Silent_p.L40L|EPHX2_uc011lam.1_5'Flank	NM_001979	NP_001970	P34913	HYES_HUMAN	epoxide hydrolase 2, cytoplasmic	106	Phosphatase.				aromatic compound catabolic process|cellular calcium ion homeostasis|drug metabolic process|inflammatory response|positive regulation of vasodilation|reactive oxygen species metabolic process|regulation of blood pressure|response to toxin|xenobiotic metabolic process	cytosol|focal adhesion|Golgi apparatus|nucleolus|peroxisome|soluble fraction	epoxide hydrolase activity|metal ion binding|protein homodimerization activity			ovary(1)	1		Ovarian(32;2.61e-05)|all_epithelial(46;0.207)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0226)|Epithelial(17;1.12e-09)|Colorectal(74;0.157)	Tamoxifen(DB00675)	GCCCCATGCTCCAGGCAGCTC	0.507		NaN											0	0	0	0.00308	0	7	13									
PROSC	11212	broad.mit.edu	37	8	37632915	37632915	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:37632915G>C	uc003xkh.2	+	6	590	c.513G>C	c.(511-513)AAG>AAC	p.K171N		NM_007198	NP_009129	O94903	PROSC_HUMAN	proline synthetase co-transcribed homolog	171							pyridoxal phosphate binding			central_nervous_system(1)	1		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)		L-Proline(DB00172)|Pyridoxal Phosphate(DB00114)	TAAACGCCAAGTGTCCTAACC	0.488		NaN											0	0	0	0.01441	0	48	76									
ASH2L	9070	broad.mit.edu	37	8	37974186	37974186	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:37974186C>T	uc003xkt.3	+	8	854	c.796C>T	c.(796-798)CCT>TCT	p.P266S	ASH2L_uc011lbk.1_Missense_Mutation_p.P127S|ASH2L_uc003xku.3_Missense_Mutation_p.P172S|ASH2L_uc010lwa.2_Missense_Mutation_p.P172S	NM_004674	NP_004665	Q9UBL3	ASH2L_HUMAN	ash2-like isoform a	266					hemopoiesis|histone H3-K4 methylation|positive regulation of cell proliferation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription from RNA polymerase II promoter	Set1C/COMPASS complex	metal ion binding|protein binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2	Colorectal(12;0.000501)	Lung NSC(58;0.0295)|all_lung(54;0.0413)				TAACATTGGTCCTGCTTATGA	0.353		NaN											0	0	0	0.013726	0	31	43									
WHSC1L1	54904	broad.mit.edu	37	8	38148131	38148131	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:38148131C>T	uc003xli.2	-	17	3498	c.2980G>A	c.(2980-2982)GAC>AAC	p.D994N	WHSC1L1_uc011lbm.1_Missense_Mutation_p.D994N|WHSC1L1_uc010lwe.2_Missense_Mutation_p.D945N	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	994	PWWP 2.				cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TCCCCCAAGTCATGTTTAAGG	0.473		NaN	T	NUP98	AML								0	0	0	0.011902	0	47	161									
C8orf86	389649	broad.mit.edu	37	8	38369913	38369913	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:38369913C>T	uc003xlx.1	-	3	689	c.664G>A	c.(664-666)GAA>AAA	p.E222K		NM_207412	NP_997295	Q6ZUL3	CH086_HUMAN	hypothetical protein LOC389649	222											0						tcttaaacttcagcacacacc	0.219		NaN											0	0	0	0.006214	0	10	48									
IKBKB	3551	broad.mit.edu	37	8	42129721	42129721	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:42129721C>G	uc003xow.1	+	2	280	c.103C>G	c.(103-105)CAG>GAG	p.Q35E	IKBKB_uc003xov.2_Missense_Mutation_p.Q35E|IKBKB_uc010lxh.1_Nonsense_Mutation_p.S24*|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.I7M|IKBKB_uc003xox.1_Translation_Start_Site|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Intron|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.I7M	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	35	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	ATGGCACAATCAGGTAGGCCC	0.607		NaN											0	0	0	0.003163	0	15	56									
KIAA0146	23514	broad.mit.edu	37	8	48508407	48508407	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:48508407G>A	uc003xqd.2	+	9	1141	c.1132G>A	c.(1132-1134)GTT>ATT	p.V378I	KIAA0146_uc011lcz.1_RNA|KIAA0146_uc011lda.1_Missense_Mutation_p.V67I|KIAA0146_uc011ldb.1_Missense_Mutation_p.V378I|KIAA0146_uc010lxs.2_Intron|KIAA0146_uc011ldc.1_Missense_Mutation_p.V308I|KIAA0146_uc011ldd.1_Missense_Mutation_p.V318I|KIAA0146_uc003xqe.2_5'UTR|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc011lde.1_Missense_Mutation_p.V67I|KIAA0146_uc010lxt.2_Missense_Mutation_p.V67I	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	378											0		Lung NSC(58;0.175)				AAGTTGCCCTGTTATTCTGAA	0.388		NaN											0	0	0	0.01441	0	58	53									
ATP6V1H	51606	broad.mit.edu	37	8	54742015	54742015	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:54742015C>T	uc003xrl.2	-	4	447	c.295G>A	c.(295-297)GAT>AAT	p.D99N	ATP6V1H_uc003xrk.2_Missense_Mutation_p.D59N|ATP6V1H_uc003xrm.2_Missense_Mutation_p.D99N|ATP6V1H_uc003xrn.2_Missense_Mutation_p.D99N|ATP6V1H_uc011ldv.1_Missense_Mutation_p.D19N|ATP6V1H_uc010lyd.2_Missense_Mutation_p.D35N	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	99					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			TGCAGCATATCATCCACCATA	0.318		NaN											0	0	0	0.006122	0	17	131									
LYPLA1	10434	broad.mit.edu	37	8	54965251	54965251	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:54965251G>A	uc003xry.2	-	7	620	c.426C>T	c.(424-426)CTC>CTT	p.L142L	LYPLA1_uc011ldx.1_Intron|LYPLA1_uc003xrz.2_Silent_p.L121L	NM_006330	NP_006321	O75608	LYPA1_HUMAN	lysophospholipase 1	142					fatty acid metabolic process|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytosol	lysophospholipase activity|palmitoyl-(protein) hydrolase activity			central_nervous_system(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;8.48e-07)|Epithelial(17;9.29e-05)|all cancers(17;0.000689)			GCCAGCAACTGAGTGCAGTGA	0.458		NaN											0	0	0	0.006214	0	8	46									
MRPL15	29088	broad.mit.edu	37	8	55060079	55060079	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:55060079G>A	uc003xsa.2	+	5	754	c.691G>A	c.(691-693)GAA>AAA	p.E231K		NM_014175	NP_054894	Q9P015	RM15_HUMAN	mitochondrial ribosomal protein L15 precursor	231					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0		Lung NSC(129;0.109)|all_epithelial(80;0.134)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;4.3e-07)|Epithelial(17;5.79e-05)|all cancers(17;0.000458)			CAAATTTCCTGAAGCACGACT	0.438		NaN											0	0	0	0.010504	0	20	121									
XKR4	114786	broad.mit.edu	37	8	56015534	56015534	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:56015534C>T	uc003xsf.2	+	1	518	c.486C>T	c.(484-486)TTC>TTT	p.F162F		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	162	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGCAAGTGTTCAGCTTCCGCT	0.652		NaN											0	0	0	0.008361	0	30	27									
XKR4	114786	broad.mit.edu	37	8	56015540	56015540	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:56015540C>T	uc003xsf.2	+	1	524	c.492C>T	c.(490-492)TTC>TTT	p.F164F		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	164	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGTTCAGCTTCCGCTGGTTTG	0.662		NaN											0	0	0	0.013537	0	11	40									
NSMAF	8439	broad.mit.edu	37	8	59555592	59555592	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:59555592C>A	uc003xtt.2	-	2	314	c.100G>T	c.(100-102)GAA>TAA	p.E34*	NSMAF_uc011lee.1_Nonsense_Mutation_p.E65*|NSMAF_uc003xtu.2_Nonsense_Mutation_p.E34*	NM_003580	NP_003571	Q92636	FAN_HUMAN	neutral sphingomyelinase (N-SMase) activation	34					ceramide metabolic process	cytoplasm|soluble fraction	protein binding|receptor signaling protein activity			ovary(1)	1		all_lung(136;0.174)|Lung NSC(129;0.2)				CTATGCTGTTCAAAGTAGTAC	0.393		NaN											1	0	3.07112e-06	0.010729	3.14652e-06	12	101									
CYP7B1	9420	broad.mit.edu	37	8	65528701	65528701	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:65528701C>T	uc003xvj.2	-	3	601	c.397G>A	c.(397-399)GAC>AAC	p.D133N		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	133					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TCATTCATGTCATGATTTTTT	0.318		NaN											0	0	0	0.008871	0	19	121									
PDE7A	5150	broad.mit.edu	37	8	66631545	66631545	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:66631545G>A	uc003xvq.2	-	13	1441	c.1429C>T	c.(1429-1431)CAG>TAG	p.Q477*	MTFR1_uc003xvo.1_Intron|PDE7A_uc003xvp.2_Nonsense_Mutation_p.Q451*	NM_002604	NP_002595	Q13946	PDE7A_HUMAN	phosphodiesterase 7A isoform b	477						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding				0			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	CGATTTTCCTGAGGTAATAAC	0.478		NaN											0	0	0	0.003163	0	13	87									
CRH	1392	broad.mit.edu	37	8	67089335	67089335	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:67089335G>A	uc003xvy.1	-	2	563	c.378C>T	c.(376-378)CTC>CTT	p.L126L		NM_000756	NP_000747	P06850	CRF_HUMAN	corticotropin releasing hormone precursor	126					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity				0		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	CGGGGCTGTCGAGCGAGCGCC	0.711		NaN									OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.009096	0	4	5									
VCPIP1	80124	broad.mit.edu	37	8	67576939	67576939	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:67576939C>T	uc003xwn.2	-	1	2514	c.2255G>A	c.(2254-2256)CGT>CAT	p.R752H	SGK3_uc003xwp.2_5'Flank|C8orf44_uc003xwo.1_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	752					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TGGACCATCACGAATGGTACT	0.448		NaN											0	0	0	0.004289	0	37	175									
VCPIP1	80124	broad.mit.edu	37	8	67577466	67577466	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:67577466G>A	uc003xwn.2	-	1	1987	c.1728C>T	c.(1726-1728)TTC>TTT	p.F576F	SGK3_uc003xwp.2_5'Flank|C8orf44_uc003xwo.1_5'Flank	NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	576					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			AAAAGTGTTTGAATCCACAAC	0.433		NaN											0	0	0	0.01441	0	59	261									
CSPP1	79848	broad.mit.edu	37	8	67976635	67976635	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:67976635T>C	uc003xxi.2	+	1	33	c.2T>C	c.(1-3)ATG>ACG	p.M1T	CSPP1_uc003xxg.1_Missense_Mutation_p.M1T|CSPP1_uc003xxh.1_RNA|CSPP1_uc003xxj.2_Missense_Mutation_p.M1T|COPS5_uc003xxd.2_5'Flank|COPS5_uc003xxe.2_5'Flank|COPS5_uc003xxf.2_5'Flank|COPS5_uc010lyv.1_5'Flank	NM_001077204	NP_001070672	Q1MSJ5	CSPP1_HUMAN	centrosome spindle pole associated protein 1	1						centrosome|microtubule|spindle				ovary(3)|breast(2)	5	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			AGGTCTGTCATGCTGTTCCCG	0.721		NaN									OREG0018811	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	4	16									
CPA6	57094	broad.mit.edu	37	8	68421789	68421789	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:68421789C>T	uc003xxq.3	-	5	753	c.497G>A	c.(496-498)GGA>GAA	p.G166E	CPA6_uc003xxr.3_Missense_Mutation_p.G18E|CPA6_uc003xxs.2_Missense_Mutation_p.G166E	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	166					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			ATATGATCTTCCAATAGAGAA	0.299		NaN											0	0	0	0.010818	0	29	147									
PRDM14	63978	broad.mit.edu	37	8	70978524	70978524	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:70978524G>A	uc003xym.2	-	5	1331	c.1129C>T	c.(1129-1131)CCT>TCT	p.P377S		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			AGGCTCACAGGAATATCCAGA	0.512		NaN											0	0	0	0.010504	0	20	112									
RPL7	6129	broad.mit.edu	37	8	74205835	74205835	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:74205835C>T	uc003xzg.2	-	1	35	c.13G>A	c.(13-15)GAA>AAA	p.E5K	RPL7_uc003xzh.1_Intron|RDH10_uc003xzi.2_5'Flank	NM_000971	NP_000962	P18124	RL7_HUMAN	ribosomal protein L7	5					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|mRNA binding|protein homodimerization activity|structural constituent of ribosome				0	Breast(64;0.0954)		Epithelial(68;0.0193)|all cancers(69;0.0766)|BRCA - Breast invasive adenocarcinoma(89;0.134)			GCAACTCACTCTACACCCTCC	0.502		NaN											0	0	0	0.000602	0	5	28									
ZNF704	619279	broad.mit.edu	37	8	81582772	81582772	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:81582772C>T	uc003yby.1	-	5	857	c.625G>A	c.(625-627)GGT>AGT	p.G209S		NM_001033723	NP_001028895	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	209	C2H2-type.					intracellular	zinc ion binding				0	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			TTCTGGATACCTGCTGCAGTG	0.507		NaN											0	0	0	0.007291	0	28	161									
SLC10A5	347051	broad.mit.edu	37	8	82606862	82606862	+	Missense_Mutation	SNP	C	C	T	rs148561963		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:82606862C>T	uc011lfs.1	-	1	346	c.346G>A	c.(346-348)GAA>AAA	p.E116K		NM_001010893	NP_001010893	Q5PT55	NTCP5_HUMAN	solute carrier family 10 (sodium/bile acid	116	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity				0						TTGATTTCTTCAATGAGTCTT	0.363		NaN											0	0	0	0.013114	0	41	183									
DCAF4L2	138009	broad.mit.edu	37	8	88885315	88885315	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:88885315C>G	uc003ydz.2	-	1	982	c.885G>C	c.(883-885)AAG>AAC	p.K295N		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	295	WD 1.									ovary(1)	1						AGTCCCACAGCTTGATAGTTC	0.493		NaN											0	0	0	0.010729	0	12	81									
RUNX1T1	862	broad.mit.edu	37	8	93017372	93017372	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:93017372C>T	uc003yfd.2	-	5	796	c.712G>A	c.(712-714)GAA>AAA	p.E238K	RUNX1T1_uc003yfc.1_Missense_Mutation_p.E211K|RUNX1T1_uc003yfe.1_Missense_Mutation_p.E201K|RUNX1T1_uc010mao.2_Missense_Mutation_p.E211K|RUNX1T1_uc011lgi.1_Missense_Mutation_p.E249K|RUNX1T1_uc003yfb.1_Missense_Mutation_p.E201K|RUNX1T1_uc003yff.1_Missense_Mutation_p.E201K	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	238					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCCCGTTTTCGTTCACATCG	0.542		NaN											0	0	0	0.005443	0	26	170									
PTDSS1	9791	broad.mit.edu	37	8	97274371	97274371	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:97274371G>A	uc003yht.1	+	1	205	c.103G>A	c.(103-105)GAC>AAC	p.D35N	MTERFD1_uc003yhs.1_5'Flank|MTERFD1_uc010mbd.1_5'Flank|PTDSS1_uc003yhu.1_5'UTR	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	35					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	CATCACCATTGACTTCTTCTA	0.577		NaN											0	0	0	0.001855	0	12	57									
PGCP	10404	broad.mit.edu	37	8	97797339	97797339	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:97797339G>C	uc003yhw.2	+	2	380	c.214G>C	c.(214-216)GAT>CAT	p.D72H	PGCP_uc010mbe.2_Missense_Mutation_p.D72H	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	72					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					ACTTCTGGTTGATACTGTTGG	0.453		NaN											0	0	0	0.00499	0	18	122									
VPS13B	157680	broad.mit.edu	37	8	100454826	100454826	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:100454826G>A	uc003yiv.2	+	23	3519	c.3408G>A	c.(3406-3408)GAG>GAA	p.E1136E	VPS13B_uc003yiw.2_Silent_p.E1136E|VPS13B_uc003yiu.1_Silent_p.E1136E|VPS13B_uc003yix.1_Silent_p.E606E	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1136					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTCTGCAGGAGATTCCATTTG	0.393		NaN											0	0	0	0.013537	0	13	52									
VPS13B	157680	broad.mit.edu	37	8	100883099	100883099	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:100883099C>T	uc003yiv.2	+	60	11665	c.11554C>T	c.(11554-11556)CAT>TAT	p.H3852Y	VPS13B_uc003yiw.2_Missense_Mutation_p.H3827Y	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3852					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCCAAACAGCCATGTCAAATA	0.433		NaN											0	0	0	0.006122	0	17	60									
RNF19A	25897	broad.mit.edu	37	8	101300012	101300012	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:101300012C>T	uc003yjj.1	-	3	708	c.391G>A	c.(391-393)GAG>AAG	p.E131K	RNF19A_uc003yjk.1_Missense_Mutation_p.E131K|RNF19A_uc003yjl.1_Missense_Mutation_p.E131K	NM_015435	NP_056250	Q9NV58	RN19A_HUMAN	ring finger protein 19	131					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			AAAGGGCACTCTATGAAGTCT	0.368		NaN											0	0	0	0.01441	0	61	231									
YWHAZ	7534	broad.mit.edu	37	8	101932959	101932959	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:101932959C>G	uc011lhe.1	-	6	877	c.700G>C	c.(700-702)GGA>CGA	p.G234R	YWHAZ_uc003yjv.2_Missense_Mutation_p.G234R|YWHAZ_uc011lhf.1_Missense_Mutation_p.G234R|YWHAZ_uc003yjw.2_Missense_Mutation_p.G234R|YWHAZ_uc010mbq.2_Missense_Mutation_p.G157R|YWHAZ_uc011lhg.1_Missense_Mutation_p.G114R|YWHAZ_uc010mbr.2_Missense_Mutation_p.G234R|YWHAZ_uc003yjx.2_Missense_Mutation_p.G234R	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	234					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	GCTTCGTCTCCTTGGGTATCC	0.458		NaN											0	0	0	0.00632	0	21	98									
ATP6V1C1	528	broad.mit.edu	37	8	104080913	104080913	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:104080913C>G	uc003ykz.3	+	13	1332	c.1087C>G	c.(1087-1089)CAA>GAA	p.Q363E	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.Q288E|ATP6V1C1_uc003yla.2_Missense_Mutation_p.Q363E|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.Q288E	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	363					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			AAACCTGAGTCAACAAGAATA	0.368		NaN											0	0	0	0.006122	0	16	100									
LRP12	29967	broad.mit.edu	37	8	105503092	105503092	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:105503092C>T	uc003yma.2	-	7	2484	c.2389G>A	c.(2389-2391)GAT>AAT	p.D797N	LRP12_uc003ymb.2_Missense_Mutation_p.D778N|LRP12_uc003ylz.2_Missense_Mutation_p.D203N	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	797	Cytoplasmic (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GAGGCAAGATCAAGAAGAGGT	0.443		NaN											0	0	0	0.003271	0	34	138									
ZFPM2	23414	broad.mit.edu	37	8	106813421	106813421	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:106813421G>A	uc003ymd.2	+	8	1134	c.1111G>A	c.(1111-1113)GGC>AGC	p.G371S	ZFPM2_uc011lhs.1_Missense_Mutation_p.G102S|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	371	C2H2-type 3.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CTGCCATTTCGGCTTCCAGAC	0.512		NaN											0	0	0	0.01441	0	43	193									
OXR1	55074	broad.mit.edu	37	8	107719112	107719112	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:107719112G>C	uc011lht.1	+	8	1465	c.1366G>C	c.(1366-1368)GAG>CAG	p.E456Q	OXR1_uc003ymf.2_Missense_Mutation_p.E455Q|OXR1_uc011lhu.1_Missense_Mutation_p.E448Q|OXR1_uc010mcg.2_Intron|OXR1_uc010mch.2_Missense_Mutation_p.E153Q|OXR1_uc003ymg.1_Missense_Mutation_p.E388Q|OXR1_uc003ymi.1_Missense_Mutation_p.E367Q	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	456					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			TTTTCTTCATGAGAATTCGTT	0.353		NaN											0	0	0	0.01441	0	86	41									
ANGPT1	284	broad.mit.edu	37	8	108509537	108509537	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:108509537G>A	uc003ymn.2	-	1	718	c.250C>T	c.(250-252)CAA>TAA	p.Q84*	ANGPT1_uc003ymo.2_Nonsense_Mutation_p.Q84*	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	84	Potential.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TCCAGATGTTGAAGTTTCTGG	0.448		NaN											0	0	0	0.009535	0	30	142									
ANGPT1	284	broad.mit.edu	37	8	108509747	108509747	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:108509747G>A	uc003ymn.2	-	1	508	c.40C>T	c.(40-42)CTG>TTG	p.L14L	ANGPT1_uc003ymo.2_Silent_p.L14L	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	14					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			ATGTGAGTCAGAATGGCAGCG	0.483		NaN											0	0	0	0.00308	0	8	51									
CSMD3	114788	broad.mit.edu	37	8	113518955	113518955	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:113518955G>A	uc003ynu.2	-	29	5019	c.4860C>T	c.(4858-4860)GTC>GTT	p.V1620V	CSMD3_uc003yns.2_Silent_p.V892V|CSMD3_uc003ynt.2_Silent_p.V1580V|CSMD3_uc011lhx.1_Silent_p.V1516V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1620	Extracellular (Potential).|CUB 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGTCTGCATTGACGGTGATAG	0.393		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.004656	0	26	124									
UTP23	84294	broad.mit.edu	37	8	117782536	117782536	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:117782536G>C	uc003yoc.2	+	2	395	c.294G>C	c.(292-294)GTG>GTC	p.V98V		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	98					rRNA processing	nucleolus					0						AGAATGCAGTGAGTGGATCAG	0.383		NaN											0	0	0	0.004656	0	27	124									
HAS2	3037	broad.mit.edu	37	8	122629422	122629422	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:122629422C>G	uc003yph.2	-	3	1190	c.652G>C	c.(652-654)GAC>CAC	p.D218H		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	218	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			GAGGCTGGGTCAAGCATAGTG	0.393		NaN											0	0	0	0.004482	0	9	52									
ZHX1	11244	broad.mit.edu	37	8	124266210	124266210	+	Silent	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:124266210C>A	uc003yqe.2	-	3	2407	c.1977G>T	c.(1975-1977)GGG>GGT	p.G659G	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Silent_p.G659G|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Silent_p.G659G	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	659					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGCCTGTACTCCCTGACTTAG	0.438		NaN											1	0	1.99824e-07	0.00499	2.05896e-07	16	161									
EFR3A	23167	broad.mit.edu	37	8	132991170	132991170	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:132991170C>G	uc003yte.2	+	13	1604	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	468						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTATCACCATCTCTCATGGAG	0.443		NaN											0	0	0	0.003271	0	35	141									
KHDRBS3	10656	broad.mit.edu	37	8	136554899	136554899	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:136554899C>G	uc003yuv.2	+	3	604	c.210C>G	c.(208-210)TTC>TTG	p.F70L	KHDRBS3_uc003yuw.2_Missense_Mutation_p.F70L	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	70	KH.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			TTTCCTAGTTCAACTTTGTGG	0.363		NaN											0	0	0	0.01441	0	134	81									
COL22A1	169044	broad.mit.edu	37	8	139648989	139648989	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:139648989T>C	uc003yvd.2	-	48	3998	c.3551A>G	c.(3550-3552)GAT>GGT	p.D1184G	COL22A1_uc011ljo.1_Missense_Mutation_p.D464G	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1184	Pro-rich.|Gly-rich.|Collagen-like 11.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTTTACCTGATCACCTTTCTG	0.413		NaN								HNSCC(7;0.00092)			0	0	0	0.01441	0	66	342									
ZNF623	9831	broad.mit.edu	37	8	144732386	144732386	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144732386G>C	uc003yzd.2	+	1	433	c.344G>C	c.(343-345)AGA>ACA	p.R115T	ZNF623_uc011lkp.1_Missense_Mutation_p.R75T|ZNF623_uc003yzc.2_Missense_Mutation_p.R75T	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CTGCTTCAGAGAGAGCTCATA	0.478		NaN											0	0	0	0.014323	0	18	146									
SCRIB	23513	broad.mit.edu	37	8	144895820	144895820	+	Missense_Mutation	SNP	C	C	G	rs144081360	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144895820C>G	uc003yzp.1	-	4	440	c.433G>C	c.(433-435)GGG>CGG	p.G145R	SCRIB_uc003yzo.1_Missense_Mutation_p.G145R|MIR937_hsa-mir-937|MI0005759_5'Flank	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	145	Sufficient for targeting to adherens junction and to inhibit cell proliferation.|LRR 5.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CCCACGTCCCCGGGCAGTGCC	0.642		NaN											0	0	0	0.008291	0	9	49									
PUF60	22827	broad.mit.edu	37	8	144898723	144898723	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144898723C>T	uc003yzs.2	-	12	1711	c.1647G>A	c.(1645-1647)CAG>CAA	p.Q549Q	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Silent_p.Q489Q|PUF60_uc003yzt.2_Silent_p.Q532Q|PUF60_uc003yzq.2_Silent_p.Q506Q	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	549	RRM 3; atypical.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CAAAACGCTCCTGGTCGTACA	0.532		NaN											0	0	0	0.01441	0	77	45									
EPPK1	83481	broad.mit.edu	37	8	144940699	144940699	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144940699C>T	uc003zaa.1	-	2	14746	c.14733G>A	c.(14731-14733)GAG>GAA	p.E4911E		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4911	Plectin 61.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCTCATCTTCTCCTGGCGGC	0.697		NaN											0	0	0	0.000602	0	5	83									
PLEC	5339	broad.mit.edu	37	8	144991306	144991306	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144991306G>A	uc003zaf.1	-	32	13264	c.13094C>T	c.(13093-13095)TCC>TTC	p.S4365F	PLEC_uc003zab.1_Missense_Mutation_p.S4228F|PLEC_uc003zac.1_Missense_Mutation_p.S4232F|PLEC_uc003zad.2_Missense_Mutation_p.S4228F|PLEC_uc003zae.1_Missense_Mutation_p.S4196F|PLEC_uc003zag.1_Missense_Mutation_p.S4206F|PLEC_uc003zah.2_Missense_Mutation_p.S4214F|PLEC_uc003zaj.2_Missense_Mutation_p.S4255F	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4365	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTCGGTGATGGAGAGCGTGCC	0.667		NaN											0	0	0	0.001168	0	6	33									
PLEC	5339	broad.mit.edu	37	8	144997136	144997136	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:144997136C>T	uc003zaf.1	-	31	7542	c.7372G>A	c.(7372-7374)GAG>AAG	p.E2458K	PLEC_uc003zab.1_Missense_Mutation_p.E2321K|PLEC_uc003zac.1_Missense_Mutation_p.E2325K|PLEC_uc003zad.2_Missense_Mutation_p.E2321K|PLEC_uc003zae.1_Missense_Mutation_p.E2289K|PLEC_uc003zag.1_Missense_Mutation_p.E2299K|PLEC_uc003zah.2_Missense_Mutation_p.E2307K|PLEC_uc003zaj.2_Missense_Mutation_p.E2348K	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2458	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGCGTGGCCTCCTGCACCGCC	0.662		NaN											0	0	0	0.000602	0	4	9									
CYC1	1537	broad.mit.edu	37	8	145151087	145151087	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145151087C>T	uc003zaz.3	+	3	430	c.387C>T	c.(385-387)TTC>TTT	p.F129F	CYC1_uc003zay.2_Silent_p.F70F	NM_001916	NP_001907	P08574	CY1_HUMAN	cytochrome c-1	129	Cytochrome c.				respiratory electron transport chain|transport	cell junction|integral to membrane|mitochondrial inner membrane|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;8.71e-40)|all cancers(56;3e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCATGGACTTCGTGGCCTACC	0.612		NaN									OREG0019052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	46	202									
GPR172A	79581	broad.mit.edu	37	8	145583548	145583548	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145583548C>T	uc003zcc.1	+	3	553	c.396C>T	c.(394-396)TTC>TTT	p.F132F	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Silent_p.F132F|GPR172A_uc003zce.1_Silent_p.F132F|GPR172A_uc010mfy.1_Silent_p.F132F|GPR172A_uc003zcf.1_Silent_p.F132F|GPR172A_uc011llc.1_Silent_p.F44F	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	132	Helical; (Potential).					integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			ATGTCACTTTCCTGCCCTTCT	0.602		NaN											0	0	0	0.007835	0	38	121									
ADCK5	203054	broad.mit.edu	37	8	145616165	145616165	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145616165G>A	uc003zch.2	+	5	506	c.452G>A	c.(451-453)GGG>GAG	p.G151E	ADCK5_uc003zcg.2_RNA|ADCK5_uc003zci.2_5'Flank	NM_174922	NP_777582	Q3MIX3	ADCK5_HUMAN	aarF domain containing kinase 5	151						integral to membrane	protein serine/threonine kinase activity			stomach(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;8.96e-41)|Epithelial(56;4.08e-40)|all cancers(56;4.51e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CTGGGCCAGGGGCTGTGCTCC	0.662		NaN											0	0	0	0.013537	0	11	39									
FOXH1	8928	broad.mit.edu	37	8	145700598	145700598	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145700598T>C	uc003zdc.2	-	2	800	c.221A>G	c.(220-222)TAC>TGC	p.Y74C		NM_003923	NP_003914	O75593	FOXH1_HUMAN	forkhead box H1	74	Fork-head.				axial mesoderm development|blood vessel development|cell migration involved in gastrulation|embryonic heart tube anterior/posterior pattern formation|floor plate formation|heart looping|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|specification of organ position|transforming growth factor beta receptor signaling pathway	activin responsive factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|R-SMAD binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.76e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CCAGCCCTCGTAGTCTTCCCT	0.682		NaN											0	0	0	0.000602	0	5	17									
ZNF251	90987	broad.mit.edu	37	8	145947214	145947214	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr8:145947214G>T	uc003zdv.3	-	5	2087	c.1831C>A	c.(1831-1833)CAA>AAA	p.Q611K		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	611	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		ACCTGATGTTGAATAAGGGTT	0.478		NaN											1	0	3.05275e-18	0.013114	3.22672e-18	48	33									
SMARCA2	6595	broad.mit.edu	37	9	2060921	2060921	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:2060921C>T	uc003zhc.2	+	9	1726	c.1627C>T	c.(1627-1629)CTG>TTG	p.L543L	SMARCA2_uc003zhd.2_Silent_p.L543L|SMARCA2_uc010mha.2_Silent_p.L534L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	543					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		TCTGACCAATCTGGTTTGGGA	0.413		NaN											0	0	0	0.010729	0	11	56									
SMARCA2	6595	broad.mit.edu	37	9	2060974	2060974	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:2060974G>T	uc003zhc.2	+	9	1779	c.1680G>T	c.(1678-1680)AGG>AGT	p.R560S	SMARCA2_uc003zhd.2_Missense_Mutation_p.R560S|SMARCA2_uc010mha.2_Missense_Mutation_p.R551S	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	560	Poly-Arg.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		agaagaggaggaggaggaaga	0.418		NaN											1	0	5.45024e-15	0.00333	5.7246e-15	23	25									
C9orf68	55064	broad.mit.edu	37	9	4661989	4661989	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:4661989G>A	uc011llz.1	-	3	325	c.87C>T	c.(85-87)CTC>CTT	p.L29L	C9orf68_uc003zik.2_RNA|C9orf68_uc003zil.2_RNA|C9orf68_uc010mhj.2_Silent_p.L29L|C9orf68_uc011lly.1_5'UTR|C9orf68_uc003zim.2_Silent_p.L29L|PPAPDC2_uc003zin.2_5'Flank	NM_001039395	NP_001034484	B4DIY4	B4DIY4_HUMAN	hypothetical protein LOC55064	29											0		Breast(48;0.0456)		GBM - Glioblastoma multiforme(50;0.0222)		GGTAGACCCCGAGGTACACAT	0.438		NaN									OREG0019084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	7	50									
KIAA1432	57589	broad.mit.edu	37	9	5745991	5745991	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:5745991G>A	uc003zji.2	+	10	1012	c.919G>A	c.(919-921)GAA>AAA	p.E307K	KIAA1432_uc003zjh.2_Missense_Mutation_p.E307K|KIAA1432_uc003zjl.3_Missense_Mutation_p.E307K|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	386						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TCAAAACACTGAAATTGAGTC	0.418		NaN											0	0	0	0.01441	0	77	86									
KIAA2026	158358	broad.mit.edu	37	9	6007317	6007317	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:6007317G>A	uc003zjq.3	-	1	687	c.471C>T	c.(469-471)TTC>TTT	p.F157F		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	157										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		AGTCCGCCACGAACTCGGTGA	0.637		NaN											0	0	0	0.003163	0	11	48									
GLDC	2731	broad.mit.edu	37	9	6605254	6605254	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:6605254C>T	uc003zkc.2	-	6	931	c.738G>A	c.(736-738)CTG>CTA	p.L246L		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	246					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	AGGGTAACTTCAGCTCAGTGA	0.433		NaN											0	0	0	0.001855	0	14	61									
KDM4C	23081	broad.mit.edu	37	9	7174617	7174617	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:7174617G>C	uc003zkh.2	+	22	3639	c.3059G>C	c.(3058-3060)AGA>ACA	p.R1020T	KDM4C_uc011lmk.1_Missense_Mutation_p.R765T|KDM4C_uc011lml.1_Missense_Mutation_p.R707T	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	1020					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						CAAGGGGAGAGAAAGAGACAA	0.458		NaN											0	0	0	0.01441	0	142	57									
C9orf123	90871	broad.mit.edu	37	9	7799696	7799696	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:7799696G>A	uc003zki.2	-	1	83	c.39C>T	c.(37-39)ATC>ATT	p.I13I	C9orf123_uc003zkj.2_Silent_p.I13I			Q96GE9	CI123_HUMAN	Homo sapiens cDNA FLJ46908 fis, clone FEBRA2004867.	13						integral to membrane					0		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)		GAGGCGCAGTGATATAGGACT	0.637		NaN											0	0	0	0.008871	0	21	7									
MPDZ	8777	broad.mit.edu	37	9	13143491	13143491	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:13143491C>T	uc010mia.1	-	26	3871	c.3814G>A	c.(3814-3816)GAC>AAC	p.D1272N	MPDZ_uc010mhx.2_Intron|MPDZ_uc011lmm.1_Intron|MPDZ_uc003zkz.3_Intron|MPDZ_uc010mhy.2_Missense_Mutation_p.D1272N|MPDZ_uc010mhz.2_Intron|MPDZ_uc011lmn.1_Intron|MPDZ_uc003zlb.3_Missense_Mutation_p.D1272N	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1272					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TGTAGAGAGTCAGCAAATGGG	0.428		NaN											0	0	0	0.01441	0	82	52									
DNAJA1	3301	broad.mit.edu	37	9	33026956	33026956	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:33026956G>A	uc003zsd.1	+	3	461	c.278G>A	c.(277-279)GGA>GAA	p.G93E	DNAJA1_uc011lnt.1_Intron|DNAJA1_uc003zse.1_Missense_Mutation_p.G93E|APTX_uc003zrz.2_5'Flank	NM_001539	NP_001530	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	93	Gly-rich.				protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		ATGTTTTTTGGAGGAGGAGGA	0.438		NaN											0	0	0	0.01441	0	60	32									
BAG1	573	broad.mit.edu	37	9	33264454	33264454	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:33264454C>T	uc003zsj.2	-	1	308	c.219G>A	c.(217-219)AAG>AAA	p.K73K	SUGT1P1_uc010mjq.1_Intron|BAG1_uc003zsi.2_5'UTR|BAG1_uc003zsk.2_5'UTR|CHMP5_uc003zsl.3_5'UTR|CHMP5_uc003zsm.3_5'Flank|CHMP5_uc011lnv.1_5'Flank	NM_004323	NP_004314	Q99933	BAG1_HUMAN	BCL2-associated athanogene isoform 1L	73	Arg-rich.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|chaperone cofactor-dependent protein refolding	cytoplasm|intermediate filament cytoskeleton|nucleus	protein binding|receptor signaling protein activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			GGGTTTTCTTCTTCATCCGCG	0.701		NaN											0	0	0	0.00499	0	16	16									
DCAF12	25853	broad.mit.edu	37	9	34125197	34125197	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:34125197G>A	uc003ztt.2	-	2	499	c.157C>T	c.(157-159)CGG>TGG	p.R53W		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	53						centrosome|CUL4 RING ubiquitin ligase complex					0						CTGACTTCCCGGTTCTTCAAG	0.453		NaN											0	0	0	0.01441	0	75	56									
CCL21	6366	broad.mit.edu	37	9	34709845	34709845	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:34709845C>G	uc003zvo.2	-	2	201	c.117G>C	c.(115-117)AAG>AAC	p.K39N		NM_002989	NP_002980	O00585	CCL21_HUMAN	small inducible cytokine A21 precursor	39					activation of Rho GTPase activity|cell maturation|cell-cell signaling|dendritic cell chemotaxis|dendritic cell dendrite assembly|establishment of T cell polarity|immune response|immunological synapse formation|inflammatory response|mesangial cell-matrix adhesion|negative regulation of leukocyte apoptosis|positive regulation of actin filament polymerization|positive regulation of cell adhesion mediated by integrin|positive regulation of cell-matrix adhesion|positive regulation of dendritic cell antigen processing and presentation|positive regulation of ERK1 and ERK2 cascade|positive regulation of filopodium assembly|positive regulation of glycoprotein biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of myeloid dendritic cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein kinase activity|positive regulation of protein kinase B signaling cascade|positive regulation of pseudopodium assembly|positive regulation of receptor-mediated endocytosis|release of sequestered calcium ion into cytosol|response to prostaglandin E stimulus|ruffle organization|T cell costimulation	extracellular space	CCR7 chemokine receptor binding|chemokine activity				0	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.173)		TGGCGGGAATCTTCCTTTGGC	0.592		NaN											0	0	0	0.01441	0	61	23									
CREB3	10488	broad.mit.edu	37	9	35732998	35732998	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:35732998G>A	uc003zxv.2	+	2	588	c.135G>A	c.(133-135)CCG>CCA	p.P45P	TLN1_uc003zxt.2_5'Flank|TLN1_uc003zxu.3_5'Flank|CREB3_uc010mla.2_5'UTR	NM_006368	NP_006359	O43889	CREB3_HUMAN	cAMP responsive element binding protein 3	45	Cytoplasmic (Potential).|Transcription activation (acidic).				chemotaxis|induction of positive chemotaxis|interspecies interaction between organisms|negative regulation of cell cycle|positive regulation of calcium ion transport|positive regulation of cell migration|positive regulation of transcription, DNA-dependent|reactivation of latent virus|regulation of cell proliferation	cytosol|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|integral to membrane|nucleus|nucleus	cAMP response element binding protein binding|CCR1 chemokine receptor binding|DNA binding|protein dimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity				0	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)	GBM - Glioblastoma multiforme(74;0.0285)		CGCAGGTACCGAGCGACTGGG	0.562		NaN											0	0	0	0.01441	0	79	38									
ZBTB5	9925	broad.mit.edu	37	9	37441574	37441574	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:37441574C>T	uc003zzx.2	-	2	1175	c.975G>A	c.(973-975)ATG>ATA	p.M325I		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		CCACCACTCTCATGTGCTCCT	0.507		NaN											0	0	0	0.009535	0	28	169									
DCAF10	79269	broad.mit.edu	37	9	37842126	37842126	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:37842126A>T	uc004aao.2	+	3	768	c.694A>T	c.(694-696)ACT>TCT	p.T232S	DCAF10_uc010mlz.2_Missense_Mutation_p.T59S	NM_024345	NP_077321	Q5QP82	DCA10_HUMAN	WD repeat domain 32	232	WD 2.					CUL4 RING ubiquitin ligase complex				central_nervous_system(1)	1						CTCTGATGACACTACAATAGC	0.358		NaN											0	0	0	0.01441	0	97	49									
PTAR1	375743	broad.mit.edu	37	9	72349085	72349085	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:72349085G>A	uc004ahj.3	-	4	431	c.409C>T	c.(409-411)CCA>TCA	p.P137S	PTAR1_uc004ahi.2_Missense_Mutation_p.P58S	NM_001099666	NP_001093136	Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat	137	PFTA 2.				protein prenylation		protein prenyltransferase activity			central_nervous_system(1)	1						CATGTTTCTGGACTCTTTGGA	0.388		NaN											0	0	0	0.013726	0	35	40									
SMC5	23137	broad.mit.edu	37	9	72930468	72930468	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:72930468G>A	uc004ahr.2	+	13	1897	c.1780G>A	c.(1780-1782)GAA>AAA	p.E594K		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	594	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						TGTAGGAACTGAAAAGACCAG	0.353		NaN											0	0	0	0.01441	0	50	49									
ALDH1A1	216	broad.mit.edu	37	9	75567869	75567869	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:75567869C>T	uc004ajd.2	-	1	101	c.48G>A	c.(46-48)TTG>TTA	p.L16L	ALDH1A1_uc011lsh.1_Intron	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	16					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	ATTGAATCTTCAAATCGGTGA	0.403		NaN											0	0	0	0.003954	0	23	44									
TRPM6	140803	broad.mit.edu	37	9	77354857	77354857	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:77354857A>G	uc004ajl.1	-	34	5507	c.5269T>C	c.(5269-5271)TCT>CCT	p.S1757P	TRPM6_uc004ajk.1_Missense_Mutation_p.S1752P|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.S708P|TRPM6_uc010mpd.1_Missense_Mutation_p.S590P|TRPM6_uc010mpe.1_Missense_Mutation_p.S304P|TRPM6_uc004ajj.1_Missense_Mutation_p.S713P	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1757	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						TGAGACCAAGAGGACATGCTT	0.493		NaN											0	0	0	0.004878	0	37	50									
OSTF1	26578	broad.mit.edu	37	9	77732450	77732450	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:77732450C>T	uc004ajv.3	+	2	276	c.65C>T	c.(64-66)ACG>ATG	p.T22M	OSTF1_uc004ajw.3_Intron|OSTF1_uc004ajx.3_Missense_Mutation_p.T25M	NM_012383	NP_036515	Q92882	OSTF1_HUMAN	osteoclast stimulating factor 1	22	SH3.				ossification|signal transduction	cytoplasm	identical protein binding			skin(1)	1						GCCCTGTATACGTTTGAACCC	0.254		NaN											0	0	0	0.00245	0	14	96									
GNA14	9630	broad.mit.edu	37	9	80262634	80262634	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:80262634G>A	uc004aku.2	-	1	599	c.76C>T	c.(76-78)CGT>TGT	p.R26C		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	26					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						TTGTCCCGACGAAGCTGTCGC	0.657		NaN											0	0	0	0.009096	0	3	9									
GNA14	9630	broad.mit.edu	37	9	80262682	80262682	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:80262682C>T	uc004aku.2	-	1	551	c.28G>A	c.(28-30)GAG>AAG	p.E10K		NM_004297	NP_004288	O95837	GNA14_HUMAN	G alpha 14	10					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(2)	2						TCCTTCTCCTCCGCGGACAGG	0.701		NaN											0	0	0	0.000602	0	4	7									
TLE1	7088	broad.mit.edu	37	9	84202699	84202699	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:84202699G>C	uc004aly.2	-	17	2315	c.1874C>G	c.(1873-1875)TCT>TGT	p.S625C	TLE1_uc004alz.2_Missense_Mutation_p.S635C|TLE1_uc011lsr.1_Missense_Mutation_p.S610C	NM_005077	NP_005068	Q04724	TLE1_HUMAN	transducin-like enhancer protein 1	625	WD 4.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			ovary(1)|skin(1)	2						GCCATCATTAGAAATGTCAAT	0.532		NaN											0	0	0	0.013114	0	47	23									
HNRNPK	3190	broad.mit.edu	37	9	86587870	86587870	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:86587870G>C	uc004ang.3	-	10	758	c.534C>G	c.(532-534)ATC>ATG	p.I178M	HNRNPK_uc011lsw.1_Translation_Start_Site|HNRNPK_uc004and.3_Translation_Start_Site|HNRNPK_uc004ank.3_Missense_Mutation_p.I178M|HNRNPK_uc004anf.3_Missense_Mutation_p.I178M|HNRNPK_uc004anh.3_Missense_Mutation_p.I154M|HNRNPK_uc011lsx.1_Missense_Mutation_p.I154M|HNRNPK_uc004ani.3_Missense_Mutation_p.I178M|HNRNPK_uc004anj.3_Missense_Mutation_p.I178M|HNRNPK_uc004ann.3_Missense_Mutation_p.I154M|HNRNPK_uc004anl.3_Missense_Mutation_p.I178M|HNRNPK_uc004anm.3_Missense_Mutation_p.I178M	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	178	5 X 4 AA repeats of G-X-G-G.|Necessary for interaction with DDX1.|2 X 22 AA approximate repeats.|Interaction with ASFV p30.|KH 2.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GGAAAAGCTTGATGGTGGTTT	0.353		NaN											0	0	0	0.010504	0	21	95									
SLC28A3	64078	broad.mit.edu	37	9	86912168	86912168	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:86912168C>T	uc010mpz.2	-	8	954	c.829G>A	c.(829-831)GAG>AAG	p.E277K	SLC28A3_uc011lsy.1_Missense_Mutation_p.E208K|SLC28A3_uc004anu.1_Missense_Mutation_p.E277K|SLC28A3_uc010mqb.2_Missense_Mutation_p.E208K	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	277	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TTGTATTTCTCACCAAAGACA	0.373		NaN											0	0	0	0.01441	0	52	43									
ZCCHC6	79670	broad.mit.edu	37	9	88958054	88958054	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:88958054G>A	uc004aoq.2	-	6	1237	c.1022C>T	c.(1021-1023)TCA>TTA	p.S341L	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.S341L|ZCCHC6_uc004aou.2_Missense_Mutation_p.S341L|ZCCHC6_uc004aov.2_Missense_Mutation_p.S341L|ZCCHC6_uc004aow.2_Missense_Mutation_p.S341L	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	341					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						GCTACAGGATGACCCATATAA	0.299		NaN											0	0	0	0.00632	0	30	88									
C9orf79	286234	broad.mit.edu	37	9	90500387	90500387	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:90500387C>T	uc004app.3	+	4	1020	c.985C>T	c.(985-987)CGG>TGG	p.R329W	C9orf79_uc004apo.1_Missense_Mutation_p.R141W	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	329						integral to membrane				ovary(3)	3						ATCCCAGCCACGGCATCTTCC	0.617		NaN											0	0	0	0.010504	0	18	10									
SEMA4D	10507	broad.mit.edu	37	9	91994364	91994364	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:91994364G>A	uc004aqo.1	-	18	2416	c.1844C>T	c.(1843-1845)TCA>TTA	p.S615L	SEMA4D_uc011ltm.1_Intron|SEMA4D_uc011ltn.1_Intron|SEMA4D_uc011lto.1_Intron|SEMA4D_uc004aqp.1_Missense_Mutation_p.S613L	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	615	Ig-like C2-type.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GTCTCCTTCTGACAAGTTGAA	0.527		NaN											0	0	0	0.01441	0	302	175									
GADD45G	10912	broad.mit.edu	37	9	92220696	92220696	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:92220696C>T	uc004aqq.2	+	3	380	c.270C>T	c.(268-270)ATC>ATT	p.I90I	GADD45G_uc004aqr.2_Silent_p.I72I	NM_006705	NP_006696	O95257	GA45G_HUMAN	growth arrest and DNA-damage-inducible, gamma	90					activation of MAPKKK activity|apoptosis|cell differentiation|DNA repair|multicellular organismal development		protein binding				0						AGAACGACATCGACATAGTGC	0.647		NaN											0	0	0	0.001855	0	13	33									
BICD2	23299	broad.mit.edu	37	9	95482795	95482795	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:95482795G>C	uc004aso.1	-	4	906	c.849C>G	c.(847-849)CTC>CTG	p.L283L	BICD2_uc004asp.1_Silent_p.L283L	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	283					microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						CACTGAACTTGAGGCCATCCA	0.577		NaN											0	0	0	0.00874	0	43	35									
WNK2	65268	broad.mit.edu	37	9	96024958	96024958	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:96024958G>A	uc004ati.1	+	13	3367	c.3367G>A	c.(3367-3369)GCC>ACC	p.A1123T	WNK2_uc011lud.1_Missense_Mutation_p.A1123T|WNK2_uc004atj.2_Missense_Mutation_p.A1123T|WNK2_uc004atk.2_Missense_Mutation_p.A760T	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1123					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						TCAGGAGCAGGCCTCACAGGA	0.637		NaN											0	0	0	0.001984	0	6	29									
BARX1	56033	broad.mit.edu	37	9	96714549	96714549	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:96714549G>C	uc010mrh.2	-	4	842	c.662C>G	c.(661-663)TCA>TGA	p.S221*	BARX1_uc004aud.2_Nonsense_Mutation_p.S67*	NM_021570	NP_067545	Q9HBU1	BARX1_HUMAN	BARX homeobox 1	221						nuclear chromosome	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGTTGGAATTGAGTTCTTCTT	0.687		NaN											0	0	0	0.000602	0	5	16									
C9orf156	51531	broad.mit.edu	37	9	100672824	100672824	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:100672824C>T	uc004axv.1	-	4	561	c.484G>A	c.(484-486)GAG>AAG	p.E162K	C9orf156_uc004axw.1_Missense_Mutation_p.E59K|C9orf156_uc004axx.1_Missense_Mutation_p.E16K|C9orf156_uc010msq.1_Missense_Mutation_p.E59K	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	162					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				GAGTCATACTCAGCTATGTAG	0.413		NaN											0	0	0	0.011902	0	44	28									
COL15A1	1306	broad.mit.edu	37	9	101767278	101767278	+	Silent	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:101767278C>A	uc004azb.1	+	9	1505	c.1299C>A	c.(1297-1299)CCC>CCA	p.P433P		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	433	Nonhelical region 1 (NC1).|4 X tandem repeats.|2.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				GTGTGGCCCCCGGGGAGCTGG	0.627		NaN											1	0	0.004672	0.004672	0.0047375	3	70									
ALG2	85365	broad.mit.edu	37	9	101980576	101980576	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:101980576C>T	uc004azf.2	-	2	961	c.891G>A	c.(889-891)GTG>GTA	p.V297V	ALG2_uc004azg.2_Silent_p.V204V	NM_033087	NP_149078	Q9H553	ALG2_HUMAN	alpha-1,3-mannosyltransferase ALG2	297					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in endoplasmic reticulum|protein N-linked glycosylation via asparagine|response to calcium ion	endoplasmic reticulum membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	alpha-1,3-mannosyltransferase activity|calcium-dependent protein binding|glycolipid 3-alpha-mannosyltransferase activity|protein anchor|protein heterodimerization activity|protein N-terminus binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.0559)				TCAAGAAGGTCACATACTGGC	0.478		NaN											0	0	0	0.012319	0	22	90									
CYLC2	1539	broad.mit.edu	37	9	105767772	105767772	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:105767772G>A	uc004bbs.2	+	5	929	c.859G>A	c.(859-861)GAT>AAT	p.D287N		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	287	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				CTCAAAGGATgatgtcaagaa	0.234		NaN											0	0	0	0.007413	0	20	20									
ABCA1	19	broad.mit.edu	37	9	107588035	107588035	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:107588035G>A	uc004bcl.2	-	17	2784	c.2471C>T	c.(2470-2472)TCG>TTG	p.S824L		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	824					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CATGGAGACCGAAGTGGTGAG	0.498		NaN											0	0	0	0.01441	0	74	35									
KIAA0368	23392	broad.mit.edu	37	9	114195538	114195538	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:114195538C>T	uc004bfe.1	-	9	1357	c.1357G>A	c.(1357-1359)GAC>AAC	p.D453N	KIAA0368_uc010muc.1_Missense_Mutation_p.D275N	NM_001080398	NP_001073867			KIAA0368 protein												0						AATTCCAGGTCTGCTGCCGTT	0.413		NaN											0	0	0	0.008871	0	18	81									
C9orf43	257169	broad.mit.edu	37	9	116187324	116187324	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:116187324G>T	uc004bho.3	+	9	1229	c.833G>T	c.(832-834)CGT>CTT	p.R278L	C9orf43_uc004bhp.2_Missense_Mutation_p.R278L	NM_152786	NP_689999	Q8TAL5	CI043_HUMAN	hypothetical protein LOC257169	278											0						TATCCTGAACGTTTGAAGAAA	0.408		NaN											1	0	6.57855e-14	0.009718	6.89635e-14	43	46									
COL27A1	85301	broad.mit.edu	37	9	116925054	116925054	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:116925054G>A	uc011lxl.1	+	2	122	c.122G>A	c.(121-123)GGA>GAA	p.G41E		NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	41					cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						TCCACCCAAGGAGCTCCTGAA	0.557		NaN											0	0	0	0.01441	0	80	61									
ATP6V1G1	9550	broad.mit.edu	37	9	117359915	117359915	+	Silent	SNP	C	C	T	rs112425042		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:117359915C>T	uc004bjc.2	+	3	374	c.249C>T	c.(247-249)ATC>ATT	p.I83I		NM_004888	NP_004879	O75348	VATG1_HUMAN	vacuolar H+ ATPase G1	83					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances				0						AGATGACCATCCTCCAGACAT	0.512		NaN											0	0	0	0.00278	0	22	71									
CEP110	11064	broad.mit.edu	37	9	123924225	123924225	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:123924225G>A	uc004bkx.1	+	31	5212	c.5181G>A	c.(5179-5181)GAG>GAA	p.E1727E	CEP110_uc004blb.1_Silent_p.E396E|CEP110_uc010mvp.1_Intron	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1727	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						CTGAATTAGAGAAGACTCAGG	0.388		NaN											0	0	0	0.01441	0	57	52									
RBM18	92400	broad.mit.edu	37	9	125023758	125023758	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:125023758G>A	uc004bma.2	-	2	180	c.14C>T	c.(13-15)ACC>ATC	p.T5I	RBM18_uc004blz.2_RNA|RBM18_uc010mvy.2_RNA|RBM18_uc011lyp.1_RNA	NM_033117	NP_149108	Q96H35	RBM18_HUMAN	RNA binding motif protein 18	5							nucleotide binding|RNA binding				0						AAGAGTTTTGGTTTCTGCTTC	0.448		NaN											0	0	0	0.005524	0	38	27									
PPP6C	5537	broad.mit.edu	37	9	127915852	127915852	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:127915852C>T	uc004bpg.3	-	6	850	c.629G>A	c.(628-630)CGA>CAA	p.R210Q	PPP6C_uc010mwv.2_Missense_Mutation_p.R247Q|PPP6C_uc010mww.2_Missense_Mutation_p.R188Q|PPP6C_uc011lzr.1_Missense_Mutation_p.R63Q	NM_002721	NP_002712	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit isoform	210					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2						ACCTGCTCCTCGGGGACTGAT	0.443		NaN											0	0	0	0.006214	0	10	71									
GARNL3	84253	broad.mit.edu	37	9	130027210	130027210	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:130027210G>A	uc011mae.1	+	1	455	c.54G>A	c.(52-54)CTG>CTA	p.L18L	GARNL3_uc011mad.1_Intron	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	18					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GTATAATACTGATGAAGCATT	0.453		NaN											0	0	0	0.011902	0	45	179									
GARNL3	84253	broad.mit.edu	37	9	130083018	130083018	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:130083018G>A	uc011mae.1	+	6	929	c.528G>A	c.(526-528)GAG>GAA	p.E176E	GARNL3_uc011mad.1_Silent_p.E154E	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	176					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ACAAATTTGAGAAAGGCCCCA	0.358		NaN											0	0	0	0.004482	0	8	62									
ENG	2022	broad.mit.edu	37	9	130592029	130592029	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:130592029G>A	uc004bsj.3	-	3	710	c.297C>T	c.(295-297)CTC>CTT	p.L99L	ENG_uc011mam.1_5'UTR|ENG_uc004bsk.3_Silent_p.L99L	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	99	Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						TGTTTACACTGAGGACCAGAA	0.602		NaN							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				0	0	0	0.004482	0	8	31									
DNM1	1759	broad.mit.edu	37	9	130981398	130981398	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:130981398C>T	uc011mau.1	+	4	543	c.456C>T	c.(454-456)ATC>ATT	p.I152I	DNM1_uc010mxr.2_Silent_p.I152I|DNM1_uc011mat.1_Silent_p.I152I	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	152					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						CTCCCGACATCGAGTTCCAGA	0.617		NaN											0	0	0	0.003755	0	37	115									
GOLGA2	2801	broad.mit.edu	37	9	131019547	131019547	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:131019547C>T	uc011maw.1	-	26	2821	c.2808G>A	c.(2806-2808)GTG>GTA	p.V936V	GOLGA2_uc010mxw.2_Silent_p.V259V|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	936						Golgi cisterna membrane	protein binding			ovary(1)	1						CGGCGAGGCTCACCTCGCAAA	0.637		NaN											0	0	0	0.00874	0	33	22									
CERCAM	51148	broad.mit.edu	37	9	131197963	131197963	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:131197963G>A	uc004buz.3	+	12	1965	c.1567G>A	c.(1567-1569)GAC>AAC	p.D523N	CERCAM_uc004buy.1_Missense_Mutation_p.D445N|CERCAM_uc010mxz.2_Missense_Mutation_p.D445N	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	523					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						CTGGCCACGGGACCTGGTGGC	0.657		NaN											0	0	0	0.001984	0	7	25									
NUP188	23511	broad.mit.edu	37	9	131749135	131749135	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:131749135G>A	uc004bws.1	+	22	2267	c.2245G>A	c.(2245-2247)GAG>AAG	p.E749K	NUP188_uc004bwu.2_Missense_Mutation_p.E92K	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	749					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						CCTGTGCCACGAGACAGACCT	0.507		NaN											0	0	0	0.013537	0	12	102									
DOLPP1	57171	broad.mit.edu	37	9	131843464	131843464	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:131843464C>T	uc004bxc.2	+	1	82	c.54C>T	c.(52-54)CTC>CTT	p.L18L	DOLPP1_uc004bxd.2_Silent_p.L18L|DOLPP1_uc004bxe.2_RNA	NM_020438	NP_065171	Q86YN1	DOPP1_HUMAN	dolichyl pyrophosphate phosphatase 1 isoform a	18					dolichyl diphosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane	dolichyldiphosphatase activity			skin(1)	1						CGGTGACCCTCACCCACGTCG	0.682		NaN											0	0	0	0.010729	0	8	38									
EXOSC2	23404	broad.mit.edu	37	9	133569207	133569207	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:133569207C>T	uc004bzu.2	+	1	50	c.29C>T	c.(28-30)GCT>GTT	p.A10V	EXOSC2_uc011mbz.1_Missense_Mutation_p.A10V|EXOSC2_uc011mca.1_RNA	NM_014285	NP_055100	Q13868	EXOS2_HUMAN	exosome component 2	10					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|positive regulation of cell growth|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	3'-5'-exoribonuclease activity|7S RNA binding|protein binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(13;0.0588)		OV - Ovarian serous cystadenocarcinoma(145;0.000324)		CTTCCAGTGGCTCGCAAGCCT	0.587		NaN											0	0	0	0.001984	0	5	12									
FIBCD1	84929	broad.mit.edu	37	9	133799256	133799256	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:133799256G>A	uc004bzz.2	-	4	969	c.724C>T	c.(724-726)CGA>TGA	p.R242*	FIBCD1_uc011mcc.1_Nonsense_Mutation_p.R242*	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	242	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		AGACAGTCTCGGGGCCGGGAG	0.632		NaN											0	0	0	0.004007	0	13	33									
BAT2L1	84726	broad.mit.edu	37	9	134340375	134340375	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:134340375G>A	uc004can.3	+	11	1685	c.1630G>A	c.(1630-1632)GAG>AAG	p.E544K	BAT2L1_uc010mzj.1_Missense_Mutation_p.E127K	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	544	Potential.						protein binding				0						AAAGGCAGGTGAGGCCCGGAA	0.612		NaN											0	0	0	0.000602	0	5	30									
GTF3C5	9328	broad.mit.edu	37	9	135906463	135906463	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:135906463G>A	uc004cci.3	+	1	402	c.65G>A	c.(64-66)CGA>CAA	p.R22Q	GTF3C5_uc010mzz.2_5'UTR|GTF3C5_uc004ccj.3_Missense_Mutation_p.R22Q	NM_012087	NP_036219	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5	22						transcription factor TFIIIC complex	DNA binding|protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		AGGCGGGAGCGACGCATGGTG	0.721		NaN											0	0	0	0.000602	0	5	15									
SURF2	6835	broad.mit.edu	37	9	136226921	136226921	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:136226921C>T	uc004cdi.2	+	4	481	c.433C>T	c.(433-435)CGC>TGC	p.R145C		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	145							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		TGACGGGCCTCGCCCGCGGGA	0.627		NaN											0	0	0	0.008871	0	19	11									
DBH	1621	broad.mit.edu	37	9	136507542	136507542	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:136507542A>G	uc004cel.2	+	3	709	c.700A>G	c.(700-702)ATT>GTT	p.I234V		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	234	Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CTGGTGCTACATTAAGGAGCT	0.607		NaN											0	0	0	0.010729	0	12	10									
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:137328351C>T	uc004cfb.2	+	10	1442	c.1280C>T	c.(1279-1281)TCC>TTC	p.S427F	RXRA_uc004cfc.1_Missense_Mutation_p.S330F	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607		NaN											0	0	0	0.01441	0	50	44									
SOHLH1	402381	broad.mit.edu	37	9	138590901	138590901	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:138590901G>A	uc004cgl.2	-	2	198	c.137C>T	c.(136-138)ACG>ATG	p.T46M	SOHLH1_uc010nbe.2_Missense_Mutation_p.T46M	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	46					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		CTCGGCCACCGTAGGGGCCTT	0.711		NaN											0	0	0	0.004482	0	8	12									
KCNT1	57582	broad.mit.edu	37	9	138662868	138662868	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:138662868G>A	uc011mdq.1	+	18	2009	c.1935G>A	c.(1933-1935)AAG>AAA	p.K645K	KCNT1_uc011mdr.1_Silent_p.K472K|KCNT1_uc010nbf.2_Silent_p.K600K|KCNT1_uc004cgo.1_Silent_p.K394K	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	645						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		AGCGGAAGAAGAGGGCCTTCT	0.652		NaN											0	0	0	0.013537	0	13	5									
CAMSAP1	157922	broad.mit.edu	37	9	138713633	138713633	+	Silent	SNP	G	G	A	rs138126670		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:138713633G>A	uc004cgr.3	-	11	2874	c.2874C>T	c.(2872-2874)CTC>CTT	p.L958L	CAMSAP1_uc004cgq.3_Silent_p.L848L|CAMSAP1_uc010nbg.2_Silent_p.L680L	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	958						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CCTCCTTCACGAGAAAGTCTT	0.562		NaN											0	0	0	0.01441	0	115	41									
MAMDC4	158056	broad.mit.edu	37	9	139748504	139748504	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:139748504G>A	uc004cjs.2	+	6	696	c.646G>A	c.(646-648)GAG>AAG	p.E216K	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	216	Extracellular (Potential).|MAM 1.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		AGATGACCTAGAGTTCTGGGA	0.627		NaN											0	0	0	0.007413	0	16	71									
ABCA2	20	broad.mit.edu	37	9	139907259	139907259	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:139907259C>T	uc011mem.1	-	30	5131	c.4983G>A	c.(4981-4983)CAG>CAA	p.Q1661Q	ABCA2_uc011mel.1_Silent_p.Q1662Q|ABCA2_uc004ckl.1_Silent_p.Q1592Q|ABCA2_uc004ckm.1_Silent_p.Q1692Q|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1661					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCACCCGCATCTGGGGCGGGT	0.687		NaN											0	0	0	0.010729	0	8	8									
SSNA1	8636	broad.mit.edu	37	9	140083657	140083657	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:140083657G>A	uc004cls.2	+	2	317	c.192G>A	c.(190-192)AAG>AAA	p.K64K	ANAPC2_uc004clq.1_5'Flank|ANAPC2_uc004clr.1_5'Flank|ANAPC2_uc011mer.1_5'Flank	NM_003731	NP_003722	O43805	SSNA1_HUMAN	nuclear autoantigen of 14 kDa	64	Potential.				G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus				breast(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.43e-05)|Epithelial(140;0.00087)		TGGCACGCAAGATTGCCTCTC	0.642		NaN											0	0	0	0.000602	0	4	25									
NRARP	441478	broad.mit.edu	37	9	140196323	140196323	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:140196323C>T	uc004cmo.2	-	1	381	c.58G>A	c.(58-60)GAG>AAG	p.E20K	C9orf167_uc011mew.1_Intron	NM_001004354	NP_001004354	Q7Z6K4	NRARP_HUMAN	NOTCH-regulated ankyrin repeat protein	20					negative regulation of Notch signaling pathway|positive regulation of canonical Wnt receptor signaling pathway						0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.185)	OV - Ovarian serous cystadenocarcinoma(145;9.07e-05)|Epithelial(140;0.000273)		CGCACAGCCTCCTGGAAGATG	0.517		NaN											0	0	0	0.001168	0	6	40									
MRPL41	64975	broad.mit.edu	37	9	140446923	140446923	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr9:140446923C>T	uc004cnh.3	+	2	520	c.390C>T	c.(388-390)CTC>CTT	p.L130L	PNPLA7_uc010ncj.1_5'Flank|PNPLA7_uc004cnf.2_5'Flank	NM_032477	NP_115866	Q8IXM3	RM41_HUMAN	mitochondrial ribosomal protein L41	130					apoptosis|cell cycle|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome				0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000415)|Epithelial(140;0.00106)		TCTTCCAGCTCTACCCCAGGA	0.557		NaN											0	0	0	0.014323	0	23	16									
IL3RA	3563	broad.mit.edu	37	X	1484114	1484114	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:1484114C>G	uc004cps.2	+	9	1192	c.843C>G	c.(841-843)TTC>TTG	p.F281L	IL3RA_uc011mhd.1_Missense_Mutation_p.F203L	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	281	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TGTATGAATTCTTGAGCGCCT	0.413		NaN											0	0	0	0.008871	0	18	30									
WWC3	55841	broad.mit.edu	37	X	10104698	10104698	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:10104698C>T	uc004csx.3	+	20	2987	c.2789C>T	c.(2788-2790)TCA>TTA	p.S930L	WWC3_uc010nds.2_Missense_Mutation_p.S594L|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	930										ovary(4)	4						AGCGACAGTTCAACGCTGCCC	0.443		NaN											0	0	0	0.001855	0	13	32									
HCCS	3052	broad.mit.edu	37	X	11130276	11130276	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:11130276G>A	uc004cuk.2	+	2	362	c.96G>A	c.(94-96)ATG>ATA	p.M32I	uc004cui.1_5'Flank|HCCS_uc004cuj.2_Missense_Mutation_p.M32I|HCCS_uc004cul.1_Missense_Mutation_p.M32I	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	32					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						AAGGGAAAATGAAAGGTAATC	0.353		NaN											0	0	0	0.001855	0	13	22									
TLR7	51284	broad.mit.edu	37	X	12906158	12906158	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:12906158C>A	uc004cvc.2	+	3	2670	c.2531C>A	c.(2530-2532)TCA>TAA	p.S844*		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	844	Helical; (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	ATTCTGTTCTCACTTTCCATA	0.453		NaN											1	0	6.73184e-63	0.01441	7.16434e-63	144	34									
ZRSR2	8233	broad.mit.edu	37	X	15809081	15809081	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:15809081G>A	uc004cxg.3	+	2	111	c.66G>A	c.(64-66)CTG>CTA	p.L22L		NM_005089	NP_005080	Q15696	U2AFM_HUMAN	U2 small nuclear RNA auxiliary factor 1-like 2	22					spliceosome assembly	U12-type spliceosomal complex	nucleotide binding|pre-mRNA 3'-splice site binding|protein binding|zinc ion binding			breast(3)	3	Hepatocellular(33;0.183)					GGGCCGCCCTGAAGAAGGAGA	0.512		NaN											0	0	0	0.004007	0	15	4									
GPR64	10149	broad.mit.edu	37	X	19032082	19032082	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:19032082G>C	uc004cyx.2	-	16	985	c.821C>G	c.(820-822)CCC>CGC	p.P274R	GPR64_uc004cyy.2_Missense_Mutation_p.P271R|GPR64_uc004cyz.2_Missense_Mutation_p.P260R|GPR64_uc004czb.2_Missense_Mutation_p.P274R|GPR64_uc004czc.2_Missense_Mutation_p.P258R|GPR64_uc004czd.2_Missense_Mutation_p.P250R|GPR64_uc004cze.2_Missense_Mutation_p.P244R|GPR64_uc004czf.2_Missense_Mutation_p.P236R|GPR64_uc004cza.2_Missense_Mutation_p.P252R|GPR64_uc004cyw.2_Missense_Mutation_p.P258R|GPR64_uc010nfj.2_Missense_Mutation_p.P244R	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	274	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					GGTAGCTTTGGGGACCTGGGA	0.542		NaN											0	0	0	0.00278	0	21	30									
MAP3K15	389840	broad.mit.edu	37	X	19413274	19413274	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:19413274G>A	uc004czk.1	-	17	2181	c.544C>T	c.(544-546)CGC>TGC	p.R182C	MAP3K15_uc004czj.1_Missense_Mutation_p.R142C	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	707	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					ACGATATTGCGGTGCTTAAGG	0.453		NaN											0	0	0	0.007835	0	41	64									
MAOA	4128	broad.mit.edu	37	X	43587477	43587477	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:43587477C>A	uc004dfy.2	+	6	742	c.561C>A	c.(559-561)CAC>CAA	p.H187Q	MAOA_uc011mkw.1_Missense_Mutation_p.H54Q	NM_000240	NP_000231	P21397	AOFA_HUMAN	monoamine oxidase A	187	Cytoplasmic.				behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			breast(2)|ovary(1)	3					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	CTGAGCCTCACGAAGTGTCTG	0.478		NaN											1	0	1.22674e-20	0.00874	1.29792e-20	43	101									
CXorf36	79742	broad.mit.edu	37	X	45017019	45017019	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:45017019G>A	uc004dgg.2	-	3	688	c.613C>T	c.(613-615)CGT>TGT	p.R205C		NM_176819	NP_789789	Q9H7Y0	CX036_HUMAN	hypothetical protein LOC79742 isoform 1	205						extracellular region				lung(1)	1						AGCTTGTCACGGTCGGTGAAG	0.632		NaN											0	0	0	0.009096	0	3	8									
CDK16	5127	broad.mit.edu	37	X	47083090	47083090	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:47083090G>A	uc004dho.2	+	2	530	c.134G>A	c.(133-135)GGA>GAA	p.G45E	CDK16_uc011mli.1_Missense_Mutation_p.G51E|CDK16_uc011mlj.1_Missense_Mutation_p.G45E|CDK16_uc011mlk.1_Missense_Mutation_p.G45E|CDK16_uc011mll.1_Missense_Mutation_p.G119E	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	45							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						AGTGACCCTGGAGAGGCCCCC	0.622		NaN											0	0	0	0.004482	0	8	2									
CDK16	5127	broad.mit.edu	37	X	47083092	47083092	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:47083092G>A	uc004dho.2	+	2	532	c.136G>A	c.(136-138)GAG>AAG	p.E46K	CDK16_uc011mli.1_Missense_Mutation_p.E52K|CDK16_uc011mlj.1_Missense_Mutation_p.E46K|CDK16_uc011mlk.1_Missense_Mutation_p.E46K|CDK16_uc011mll.1_Missense_Mutation_p.E120K	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	46							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						TGACCCTGGAGAGGCCCCCAC	0.627		NaN											0	0	0	0.004482	0	8	2									
CDK16	5127	broad.mit.edu	37	X	47083915	47083915	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:47083915G>A	uc004dho.2	+	3	730	c.334G>A	c.(334-336)GAG>AAG	p.E112K	CDK16_uc011mli.1_Missense_Mutation_p.E118K|CDK16_uc011mlj.1_Missense_Mutation_p.E112K|CDK16_uc011mlk.1_Missense_Mutation_p.E112K|CDK16_uc011mll.1_Missense_Mutation_p.E186K	NM_006201	NP_006192	Q00536	CDK16_HUMAN	PCTAIRE protein kinase 1 isoform 1	112							ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)	1						GATCTCCACTGAGGTGCTTGA	0.577		NaN											0	0	0	0.005443	0	27	3									
TFE3	7030	broad.mit.edu	37	X	48891000	48891000	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:48891000G>C	uc004dmb.3	-	8	1354	c.1116C>G	c.(1114-1116)CTC>CTG	p.L372L	TFE3_uc004dmc.3_Silent_p.L267L|TFE3_uc004dme.1_RNA	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	372	Helix-loop-helix motif.				humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						ACTTAGGGATGAGAGTGCCCA	0.567		NaN	T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								0	0	0	0.001984	0	7	17									
CACNA1F	778	broad.mit.edu	37	X	49079298	49079298	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:49079298C>T	uc004dnb.2	-	16	2181	c.2119_splice	c.e16-1	p.I707_splice	CACNA1F_uc010nip.2_Splice_Site_p.I696_splice	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,						axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CTGTCAGGATCTGGGGGTGGG	0.547		NaN											0	0	0	0.007413	0	18	26									
CCNB3	85417	broad.mit.edu	37	X	50052841	50052841	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:50052841G>A	uc004dox.3	+	6	1970	c.1672G>A	c.(1672-1674)GAA>AAA	p.E558K	CCNB3_uc004doy.2_Missense_Mutation_p.E558K|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	558					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TATGATTGGTGAAGATAAGAA	0.378		NaN											0	0	0	0.008361	0	31	9									
SHROOM4	57477	broad.mit.edu	37	X	50370665	50370665	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:50370665C>G	uc004dpe.2	-	5	2932	c.2906G>C	c.(2905-2907)GGG>GCG	p.G969A	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	969					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CCATTTGTCCCCAGGAAATTC	0.493		NaN											0	0	0	0.006122	0	19	18									
FGD1	2245	broad.mit.edu	37	X	54473866	54473866	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:54473866C>T	uc004dtg.2	-	17	3192	c.2458G>A	c.(2458-2460)GAG>AAG	p.E820K		NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	820					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						ACGCTGTTCTCTGCAGCCACT	0.537		NaN											0	0	0	0.007413	0	18	3									
PAGE5	90737	broad.mit.edu	37	X	55247849	55247849	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:55247849G>A	uc004duj.2	+	2	336	c.94G>A	c.(94-96)GAA>AAA	p.E32K	PAGE5_uc004duk.2_Missense_Mutation_p.E12K	NM_130467	NP_569734	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 isoform 1	32											0						CCAATCCTCAGAAAGAGGAAA	0.328		NaN											0	0	0	0.007413	0	19	24									
ZXDA	7789	broad.mit.edu	37	X	57935505	57935505	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:57935505G>A	uc004dve.2	-	1	1563	c.1350C>T	c.(1348-1350)TTC>TTT	p.F450F		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	450	C2H2-type 7.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						AGTCACAAAGGAAAGGTCTCT	0.512		NaN											0	0	0	0.010504	0	17	24									
MED12	9968	broad.mit.edu	37	X	70355032	70355032	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:70355032G>A	uc004dyy.2	+	36	5153	c.4954G>A	c.(4954-4956)GAG>AAG	p.E1652K	MED12_uc011mpq.1_Missense_Mutation_p.E1652K|MED12_uc004dyz.2_Missense_Mutation_p.E1652K|MED12_uc004dza.2_Missense_Mutation_p.E1499K|MED12_uc010nla.2_Missense_Mutation_p.E278K	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1652	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CATCACGTGTGAGCCACAGGG	0.562		NaN											0	0	0	0.008871	0	21	1									
RPS4X	6191	broad.mit.edu	37	X	71494972	71494972	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:71494972C>T	uc004ear.2	-	4	387	c.291G>A	c.(289-291)GAG>GAA	p.E97E	RPS4X_uc011mqb.1_Silent_p.E97E	NM_001007	NP_000998	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked X isoform	97	S4 RNA-binding.				endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0	Renal(35;0.156)					GACGGAAATTCTCTCCCGTCT	0.483		NaN											0	0	0	0.008291	0	10	6									
RPS4X	6191	broad.mit.edu	37	X	71494974	71494974	+	Missense_Mutation	SNP	C	C	G	rs113141010		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:71494974C>G	uc004ear.2	-	4	385	c.289G>C	c.(289-291)GAG>CAG	p.E97Q	RPS4X_uc011mqb.1_Missense_Mutation_p.E97Q	NM_001007	NP_000998	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked X isoform	97	S4 RNA-binding.				endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0	Renal(35;0.156)					CGGAAATTCTCTCCCGTCTTG	0.483		NaN											0	0	0	0.008291	0	10	6									
PHKA1	5255	broad.mit.edu	37	X	71846900	71846900	+	Splice_Site	SNP	C	C	G			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:71846900C>G	uc004eax.3	-	17	2016	c.1715_splice	c.e17-1	p.D572_splice	PHKA1_uc004eay.3_Splice_Site_p.D572_splice|PHKA1_uc011mqi.1_Splice_Site_p.D572_splice	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform						glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					CCATCTTCATCTTGAAATGAA	0.363		NaN											0	0	0	0.00333	0	26	11									
RLIM	51132	broad.mit.edu	37	X	73812835	73812835	+	Silent	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:73812835G>A	uc004ebu.2	-	5	605	c.315C>T	c.(313-315)GTC>GTT	p.V105V	RLIM_uc004ebw.2_Silent_p.V105V	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	105					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CAGTTTGTCTGACAGAGTTAA	0.428		NaN											0	0	0	0.00623	0	39	22									
PCDH19	57526	broad.mit.edu	37	X	99661856	99661856	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:99661856G>C	uc010nmz.2	-	1	3416	c.1740C>G	c.(1738-1740)AAC>AAG	p.N580K	PCDH19_uc004efw.3_Missense_Mutation_p.N580K|PCDH19_uc004efx.3_Missense_Mutation_p.N580K	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	580	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CTATGCCAGAGTTGCGGGGTA	0.587		NaN											0	0	0	0.006122	0	17	12									
RNF128	79589	broad.mit.edu	37	X	105937496	105937496	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:105937496G>C	uc004emk.2	+	1	429	c.264G>C	c.(262-264)AAG>AAC	p.K88N		NM_024539	NP_078815	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTAATACTAAGAAGCCCTGGA	0.408		NaN											0	0	0	0.008871	0	21	11									
GRIA3	2892	broad.mit.edu	37	X	122561889	122561889	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:122561889G>C	uc004etq.3	+	13	2268	c.1975G>C	c.(1975-1977)GAG>CAG	p.E659Q	GRIA3_uc004etr.3_Missense_Mutation_p.E659Q|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	659	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	CCTGACTGTGGAGAGGATGGT	0.463		NaN											0	0	0	0.01441	0	51	24									
GRIA3	2892	broad.mit.edu	37	X	122598816	122598816	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:122598816G>A	uc004etq.3	+	14	2470	c.2177G>A	c.(2176-2178)CGA>CAA	p.R726Q	GRIA3_uc004etr.3_Missense_Mutation_p.R726Q|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	726	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	GCCCGAGTGCGAAAGTCCAAG	0.458		NaN											0	0	0	0.004656	0	24	13									
USP26	83844	broad.mit.edu	37	X	132162129	132162129	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:132162129C>T	uc010nrm.1	-	6	590	c.120G>A	c.(118-120)CTG>CTA	p.L40L	USP26_uc011mvf.1_Silent_p.L40L	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	40					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					TTTTGAAATACAGCACCAGTC	0.353		NaN											0	0	0	0.012319	0	23	17									
FGF13	2258	broad.mit.edu	37	X	138286239	138286239	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:138286239C>T	uc004faq.2	-	1	207	c.31G>A	c.(31-33)GAG>AAG	p.E11K	FGF13_uc004far.2_5'UTR|FGF13_uc011mwj.1_Missense_Mutation_p.E11K|FGF13_uc011mwk.1_Missense_Mutation_p.E11K	NM_001139502	NP_001132974	Q92913	FGF13_HUMAN	fibroblast growth factor 13 isoform 3	Error:Variant_position_missing_in_Q92913_after_alignment					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GCATCTTTCTCCTCTTTGGGC	0.622		NaN											0	0	0	0.008291	0	11	6									
ZNF185	7739	broad.mit.edu	37	X	152137987	152137987	+	Silent	SNP	C	C	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:152137987C>T	uc010ntv.1	+	21	1967	c.1930C>T	c.(1930-1932)CTA>TTA	p.L644L	ZNF185_uc011myg.1_Silent_p.L676L|ZNF185_uc011myh.1_Silent_p.L647L|ZNF185_uc011myi.1_Silent_p.L615L|ZNF185_uc011myj.1_Silent_p.L585L|ZNF185_uc011myk.1_Silent_p.L645L|ZNF185_uc004fgw.3_Silent_p.L423L|ZNF185_uc004fgu.2_Silent_p.L273L|ZNF185_uc004fgv.2_Silent_p.L341L|ZNF185_uc004fgx.2_Silent_p.L282L	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	644	LIM zinc-binding.					cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAAGATTACCCTAGAACATCT	0.473		NaN											0	0	0	0.004482	0	7	3									
HCFC1	3054	broad.mit.edu	37	X	153223253	153223253	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:153223253G>C	uc004fjp.2	-	12	2641	c.2113C>G	c.(2113-2115)CCT>GCT	p.P705A		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	705	Interaction with SIN3A.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAGTCACAGGACCCGTGGAC	0.547		NaN											0	0	0	0.012319	0	19	13									
FLNA	2316	broad.mit.edu	37	X	153580262	153580262	+	Silent	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:153580262G>C	uc004fkk.2	-	42	7146	c.6897C>G	c.(6895-6897)GTC>GTG	p.V2299V	FLNA_uc004fki.2_Silent_p.V342V|FLNA_uc011mzn.1_Silent_p.V432V|FLNA_uc010nuu.1_Silent_p.V2291V	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2299	Filamin 21.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGGCTCCTGGACCACATAAG	0.637		NaN											0	0	0	0.004482	0	9	7									
IL9R	3581	broad.mit.edu	37	X	155232652	155232652	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:155232652G>A	uc004fnv.1	+	2	289	c.110G>A	c.(109-111)TGC>TAC	p.C37Y	IL9R_uc010nvn.2_Missense_Mutation_p.C16Y|IL9R_uc004fnu.1_Missense_Mutation_p.C84Y	NM_002186	NP_002177	Q01113	IL9R_HUMAN	interleukin 9 receptor precursor	37					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACCTGTGTCTGCTTGGGAGTC	0.597		NaN											0	0	0	0.00333	0	24	56									
USP9Y	8287	broad.mit.edu	37	Y	14885574	14885574	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrY:14885574G>T	uc004fst.1	+	17	2991	c.2046G>T	c.(2044-2046)TGG>TGT	p.W682C	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	682					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						AACAAATATGGAAGTGCTTAG	0.393		NaN											1	0	2.31418e-15	0.01441	2.43303e-15	51	20									
USP9Y	8287	broad.mit.edu	37	Y	14885804	14885804	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrY:14885804G>C	uc004fst.1	+	17	3221	c.2276G>C	c.(2275-2277)AGA>ACA	p.R759T	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	759					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						ATAGCAAAAAGAAGATCCTAT	0.353		NaN											0	0	0	0.012319	0	21	8									
USP9Y	8287	broad.mit.edu	37	Y	14885824	14885824	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrY:14885824G>T	uc004fst.1	+	17	3241	c.2296G>T	c.(2296-2298)GAT>TAT	p.D766Y	USP9Y_uc010nwu.1_RNA	NM_004654	NP_004645	O00507	USP9Y_HUMAN	ubiquitin specific protease 9, Y-linked	766					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						TATGATGGATGATTTGGAATT	0.313		NaN											1	0	1.33834e-09	0.007413	1.38957e-09	18	6									
PIGK	10026	broad.mit.edu	37	1	77588010	77588010	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:77588010delC	uc001dhk.2	-	10	1066	c.1021delG	c.(1021-1023)GAAfs	p.E341fs	PIGK_uc010orj.1_Frame_Shift_Del_p.E265fs|PIGK_uc009wbx.2_Frame_Shift_Del_p.E247fs	NM_005482	NP_005473	Q92643	GPI8_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	341	Lumenal (Potential).			Missing: Loss of activity.	attachment of GPI anchor to protein|C-terminal protein lipidation|protein thiol-disulfide exchange|proteolysis	GPI-anchor transamidase complex	cysteine-type endopeptidase activity|GPI-anchor transamidase activity|protein binding			ovary(2)|pancreas(1)	3						TTCAGAGGTTCCATTAGTTTC	0.313		NaN											NaN	NaN	NaN	NaN	NaN	21	99	---	---							
HIST3H2A	92815	broad.mit.edu	37	1	228645368	228645386	+	Frame_Shift_Del	DEL	AGACCGGGGCGCCGGCGCC	AGACCGGGGCGCCGGCGCC	-	rs143327597	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr1:228645368_228645386delAGACCGGGGCGCCGGCGCC	uc001hsy.2	-	1	175_193	c.133_151delGGCGCCGGCGCCCCGGTCT	c.(133-153)GGCGCCGGCGCCCCGGTCTATfs	p.G45fs	HIST3H2BB_uc001hsz.2_5'Flank	NM_033445	NP_254280	Q7L7L0	H2A3_HUMAN	histone cluster 3, H2a	45_51					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)	1		Prostate(94;0.183)				GCGGCCAGATAGACCGGGGCGCCGGCGCCCACGCGCTCC	0.703		NaN											NaN	NaN	NaN	NaN	NaN	7	10	---	---							
HERC4	26091	broad.mit.edu	37	10	69748513	69748513	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:69748513delC	uc001jng.3	-	15	2024	c.1713delG	c.(1711-1713)TTGfs	p.L571fs	HERC4_uc009xpq.2_Frame_Shift_Del_p.L112fs|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Frame_Shift_Del_p.L571fs|HERC4_uc009xpr.2_Frame_Shift_Del_p.L571fs|HERC4_uc001jni.3_Frame_Shift_Del_p.L315fs|HERC4_uc001jnj.2_Frame_Shift_Del_p.L571fs	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	571					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						TGTAGAGTTTCAAAAGATGTA	0.343		NaN											NaN	NaN	NaN	NaN	NaN	57	176	---	---							
CHUK	1147	broad.mit.edu	37	10	101953863	101953865	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr10:101953863_101953865delTCT	uc001kqp.2	-	18	1905_1907	c.1850_1852delAGA	c.(1849-1854)AAGATT>ATT	p.K617del		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	617					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		AGATCAATAATCTTCTGCTTACA	0.433		NaN											NaN	NaN	NaN	NaN	NaN	41	44	---	---							
AVIL	10677	broad.mit.edu	37	12	58191766	58191783	+	Splice_Site	DEL	CAGAGAGGTAATTCTAAG	CAGAGAGGTAATTCTAAG	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:58191766_58191783delCAGAGAGGTAATTCTAAG	uc001sqj.1	-	19	2376	c.2347_splice	c.e19-1	p.N783_splice	AVIL_uc009zqe.1_Splice_Site_p.N776_splice	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin						actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					AAGTCCTGTTCAGAGAGGTAATTCTAAGAGAGAAAACA	0.436		NaN											NaN	NaN	NaN	NaN	NaN	20	57	---	---							
SLC25A3	5250	broad.mit.edu	37	12	98995210	98995211	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr12:98995210_98995211delTA	uc001tfo.2	+	8	1113_1114	c.993_994delTA	c.(991-996)TTTATCfs	p.F331fs	SLC25A3_uc001tfm.2_Frame_Shift_Del_p.F330fs|SLC25A3_uc001tfn.2_Frame_Shift_Del_p.F330fs|SLC25A3_uc001tfp.2_Frame_Shift_Del_p.F330fs|SLC25A3_uc001tfq.2_Frame_Shift_Del_p.F200fs|SLC25A3_uc001tfr.2_Frame_Shift_Del_p.F331fs|SLC25A3_uc001tfs.2_Frame_Shift_Del_p.F287fs|SLC25A3_uc009ztn.2_Frame_Shift_Del_p.F293fs|SLC25A3_uc001tft.2_Frame_Shift_Del_p.F330fs	NM_005888	NP_005879	Q00325	MPCP_HUMAN	solute carrier family 25 member 3 isoform a	331_332	Solcar 3.|Helical; Name=6; (Potential).				generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity				0		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)		TACAGTGGTTTATCTATGACTC	0.46		NaN											NaN	NaN	NaN	NaN	NaN	81	121	---	---							
MIPEP	4285	broad.mit.edu	37	13	24411850	24411850	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr13:24411850delC	uc001uox.3	-	13	1484	c.1384delG	c.(1384-1386)GACfs	p.D462fs		NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	462					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		AGTTGATAGTCTCCATCTTCC	0.393		NaN											NaN	NaN	NaN	NaN	NaN	24	117	---	---							
MIPOL1	145282	broad.mit.edu	37	14	37717025	37717051	+	Splice_Site	DEL	TTATTTTAGCTGCAAATCTTGGAGCAA	TTATTTTAGCTGCAAATCTTGGAGCAA	-	rs116728484	by1000genomes	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr14:37717025_37717051delTTATTTTAGCTGCAAATCTTGGAGCAA	uc001wuc.2	+	4	444	c.-59_splice	c.e4-1		MIPOL1_uc010amr.2_Splice_Site|MIPOL1_uc001wub.3_Splice_Site|MIPOL1_uc001wud.2_Splice_Site|MIPOL1_uc010ams.2_Splice_Site|MIPOL1_uc001wue.2_Splice_Site|MIPOL1_uc010amt.2_Intron	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1											ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AGAGTTGGCTTTATTTTAGCTGCAAATCTTGGAGCAAAAACCAGAGA	0.339		NaN											NaN	NaN	NaN	NaN	NaN	7	26	---	---							
GREM1	26585	broad.mit.edu	37	15	33023246	33023247	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr15:33023246_33023247insA	uc001zhe.1	+	2	514_515	c.355_356insA	c.(355-357)TACfs	p.Y119fs	GREM1_uc001zhd.1_Frame_Shift_Ins_p.Y49fs|GREM1_uc010uby.1_Frame_Shift_Ins_p.Y78fs	NM_013372	NP_037504	O60565	GREM1_HUMAN	gremlin-1 precursor	119	CTCK.				negative regulation of BMP signaling pathway|nervous system development|regulation of epithelial to mesenchymal transition	extracellular space	cytokine activity				0		all_lung(180;1.49e-09)		all cancers(64;2.97e-18)|Epithelial(43;3.15e-12)|GBM - Glioblastoma multiforme(186;2.32e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0107)		CCGCTTCTGTTACGGCCAGTGC	0.535		NaN											NaN	NaN	NaN	NaN	NaN	43	61	---	---							
TRAF4	9618	broad.mit.edu	37	17	27075334	27075357	+	In_Frame_Del	DEL	GCCCGCATGATGCGGCGGCTGCTG	GCCCGCATGATGCGGCGGCTGCTG	-	rs35932778	byFrequency	TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:27075334_27075357delGCCCGCATGATGCGGCGGCTGCTG	uc002hcs.2	+	5	625_648	c.517_540delGCCCGCATGATGCGGCGGCTGCTG	c.(517-540)GCCCGCATGATGCGGCGGCTGCTGdel	p.ARMMRRLL173del	TRAF4_uc002hcq.1_Intron	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	173_180	TRAF-type 2.				apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			TAAGTGTGGTGCCCGCATGATGCGGCGGCTGCTGGCCCAGCATG	0.576		NaN											NaN	NaN	NaN	NaN	NaN	10	39	---	---							
MAPT	4137	broad.mit.edu	37	17	44096051	44096072	+	Frame_Shift_Del	DEL	GTCCCTGGACAATATCACCCAC	GTCCCTGGACAATATCACCCAC	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:44096051_44096072delGTCCCTGGACAATATCACCCAC	uc002ijr.3	+	13	2336_2357	c.2016_2037delGTCCCTGGACAATATCACCCAC	c.(2014-2037)GGGTCCCTGGACAATATCACCCACfs	p.G672fs	MAPT_uc010dau.2_Frame_Shift_Del_p.G690fs|MAPT_uc002ijs.3_Frame_Shift_Del_p.G355fs|MAPT_uc002ijx.3_Frame_Shift_Del_p.G326fs|MAPT_uc002ijt.3_Frame_Shift_Del_p.G297fs|MAPT_uc002iju.3_Frame_Shift_Del_p.G266fs|MAPT_uc002ijv.3_Frame_Shift_Del_p.G273fs	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	672_679	Tau/MAP 4.				cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CGAAGATTGGGTCCCTGGACAATATCACCCACGTCCCTGGCG	0.5		NaN											NaN	NaN	NaN	NaN	NaN	25	116	---	---							
WDR45L	56270	broad.mit.edu	37	17	80588887	80588889	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr17:80588887_80588889delCTT	uc002kfq.2	-	3	347_349	c.152_154delAAG	c.(151-156)GAAGGA>GGA	p.E51del	WDR45L_uc002kfr.2_RNA	NM_019613	NP_062559	Q5MNZ6	WIPI3_HUMAN	WDR45-like	51					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1	Breast(20;0.00106)|all_neural(118;0.0952)	all_cancers(8;0.101)|all_epithelial(8;0.198)	BRCA - Breast invasive adenocarcinoma(99;0.0262)|OV - Ovarian serous cystadenocarcinoma(97;0.0835)			CCAACTCCTCCTTCTAGAAATTC	0.335		NaN											NaN	NaN	NaN	NaN	NaN	55	181	---	---							
RBBP8	5932	broad.mit.edu	37	18	20596832	20596833	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr18:20596832_20596833insC	uc002ktw.2	+	17	2730_2731	c.2399_2400insC	c.(2398-2400)CGGfs	p.R800fs	RBBP8_uc002kty.2_Frame_Shift_Ins_p.R800fs|RBBP8_uc002ktz.2_Intron|RBBP8_uc002kua.2_Frame_Shift_Ins_p.R805fs|RBBP8_uc010xap.1_Frame_Shift_Ins_p.R138fs	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	800					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			GAGGTGGTTCGGAAAAAAGAGG	0.351		NaN						Direct_reversal_of_damage|Homologous_recombination					NaN	NaN	NaN	NaN	NaN	9	35	---	---							
CC2D1A	54862	broad.mit.edu	37	19	14037992	14037992	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr19:14037992delC	uc002mxo.2	+	22	2529	c.2230delC	c.(2230-2232)CTGfs	p.L744fs	CC2D1A_uc002mxp.2_Frame_Shift_Del_p.L744fs|CC2D1A_uc010dzh.2_Frame_Shift_Del_p.L313fs|CC2D1A_uc002mxq.1_3'UTR	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	744	C2.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			ACACAGGGGGCTGTTCAAGAC	0.602		NaN											NaN	NaN	NaN	NaN	NaN	8	125	---	---							
FOSL2	2355	broad.mit.edu	37	2	28634949	28634950	+	Frame_Shift_Ins	INS	-	-	CT			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:28634949_28634950insCT	uc002rma.2	+	4	1424_1425	c.615_616insCT	c.(613-618)GGGCTGfs	p.G205fs	FOSL2_uc010ymi.1_Frame_Shift_Ins_p.G166fs	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	205_206					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CAGCCCCTGGGCTGCAGCCCAT	0.663		NaN											NaN	NaN	NaN	NaN	NaN	23	93	---	---							
POU3F3	5455	broad.mit.edu	37	2	105473173	105473180	+	Frame_Shift_Del	DEL	CGCAGGGC	CGCAGGGC	-	rs140129722		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr2:105473173_105473180delCGCAGGGC	uc010ywg.1	+	1	1205_1212	c.1205_1212delCGCAGGGC	c.(1204-1212)GCGCAGGGCfs	p.A402fs		NM_006236	NP_006227	P20264	PO3F3_HUMAN	POU class 3 homeobox 3	402_404					metanephric ascending thin limb development|metanephric DCT cell differentiation|metanephric macula densa development|metanephric thick ascending limb development|negative regulation of apoptosis|positive regulation of cell proliferation	nucleus	sequence-specific DNA binding			ovary(1)	1						AAGATCGCGGCGCAGGGCCGCAAGCGCA	0.625		NaN											NaN	NaN	NaN	NaN	NaN	12	26	---	---							
NCOA5	57727	broad.mit.edu	37	20	44691177	44691186	+	Frame_Shift_Del	DEL	GGTCTGGGGC	GGTCTGGGGC	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr20:44691177_44691186delGGTCTGGGGC	uc002xrd.2	-	7	2021_2030	c.1493_1502delGCCCCAGACC	c.(1492-1503)GGCCCCAGACCTfs	p.G498fs	NCOA5_uc002xrc.2_3'UTR|NCOA5_uc002xre.2_Frame_Shift_Del_p.G498fs	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	498_501	Transcription activation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				AGGAGCCCCAGGTCTGGGGCCCATGTTCTG	0.557		NaN											NaN	NaN	NaN	NaN	NaN	24	60	---	---							
PBRM1	55193	broad.mit.edu	37	3	52584525	52584526	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:52584525_52584526delCC	uc003des.2	-	29	4820_4821	c.4808_4809delGG	c.(4807-4809)CGGfs	p.R1603fs	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Frame_Shift_Del_p.R1496fs|PBRM1_uc003der.2_Frame_Shift_Del_p.R1516fs|PBRM1_uc003det.2_Frame_Shift_Del_p.R1511fs|PBRM1_uc003deu.2_Frame_Shift_Del_p.R1566fs|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Frame_Shift_Del_p.R1548fs|PBRM1_uc010hmk.1_Frame_Shift_Del_p.R1523fs|PBRM1_uc003dey.2_Frame_Shift_Del_p.R1496fs	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1603					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AGTGAAGAAGCCGCTGGGTCTT	0.545		NaN	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								NaN	NaN	NaN	NaN	NaN	15	65	---	---							
AMOTL2	51421	broad.mit.edu	37	3	134077396	134077397	+	Frame_Shift_Ins	INS	-	-	T			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr3:134077396_134077397insT	uc003eqf.2	-	9	2557_2558	c.2440_2441insA	c.(2440-2442)AGAfs	p.R814fs	AMOTL2_uc003eqg.1_Frame_Shift_Ins_p.R757fs|AMOTL2_uc003eqh.1_Frame_Shift_Ins_p.R754fs|AMOTL2_uc010htx.1_5'Flank|AMOTL2_uc003eqe.1_Frame_Shift_Ins_p.R382fs	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	756										large_intestine(1)	1						AGAGGCTGCTCTCTGGCTACTG	0.629		NaN									OREG0015814	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	8	44	---	---							
GRK4	2868	broad.mit.edu	37	4	3015470	3015470	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:3015470delA	uc003ggn.1	+	8	1111	c.656delA	c.(655-657)CAAfs	p.Q219fs	GRK4_uc003ggo.1_Frame_Shift_Del_p.Q219fs|GRK4_uc003ggp.1_Frame_Shift_Del_p.Q187fs|GRK4_uc003ggq.1_Frame_Shift_Del_p.Q187fs	NM_182982	NP_892027	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4 isoform	219	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AAAAAGCTACAAAAAAAAAGA	0.393		NaN											NaN	NaN	NaN	NaN	NaN	7	371	---	---							
COPS4	51138	broad.mit.edu	37	4	83978470	83978477	+	Frame_Shift_Del	DEL	CAATGAGC	CAATGAGC	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr4:83978470_83978477delCAATGAGC	uc003hoa.2	+	6	763_770	c.624_631delCAATGAGC	c.(622-633)TACAATGAGCTCfs	p.Y208fs	COPS4_uc003hob.2_Frame_Shift_Del_p.Y208fs|COPS4_uc010ijw.2_Frame_Shift_Del_p.Y208fs|COPS4_uc010ijx.2_Frame_Shift_Del_p.Y208fs	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	208_211	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				CACAAAGGTACAATGAGCTCTCTTACAA	0.365		NaN											NaN	NaN	NaN	NaN	NaN	33	48	---	---							
FBN2	2201	broad.mit.edu	37	5	127647056	127647056	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr5:127647056delA	uc003kuu.2	-	39	5449	c.5010delT	c.(5008-5010)TTTfs	p.F1670fs		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1670	EGF-like 27; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGAAGCTCCCAAAAGTGTTGA	0.483		NaN											NaN	NaN	NaN	NaN	NaN	12	44	---	---							
BAT2	7916	broad.mit.edu	37	6	31602048	31602062	+	In_Frame_Del	DEL	GGGCTCTAAGCCTGA	GGGCTCTAAGCCTGA	-	rs139245110		TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:31602048_31602062delGGGCTCTAAGCCTGA	uc003nvb.3	+	19	5004_5018	c.4755_4769delGGGCTCTAAGCCTGA	c.(4753-4770)TTGGGCTCTAAGCCTGAG>TTG	p.GSKPE1586del	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_In_Frame_Del_p.GSKPE1586del	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1586_1590	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						CTGGATTCTTGGGCTCTAAGCCTGAGGGCCCAGGC	0.512		NaN											NaN	NaN	NaN	NaN	NaN	61	509	---	---							
LAMA2	3908	broad.mit.edu	37	6	129674397	129674412	+	Frame_Shift_Del	DEL	CCCTGTGACCCTGTCA	CCCTGTGACCCTGTCA	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr6:129674397_129674412delCCCTGTGACCCTGTCA	uc003qbn.2	+	32	4717_4732	c.4612_4627delCCCTGTGACCCTGTCA	c.(4612-4629)CCCTGTGACCCTGTCACAfs	p.P1538fs	LAMA2_uc003qbo.2_Frame_Shift_Del_p.P1538fs	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1538_1543	Laminin EGF-like 17.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ACTGCCTGTGCCCTGTGACCCTGTCACAGGATTCTG	0.583		NaN											NaN	NaN	NaN	NaN	NaN	23	62	---	---							
ZNF804B	219578	broad.mit.edu	37	7	88965470	88965471	+	Frame_Shift_Ins	INS	-	-	ATCC			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chr7:88965470_88965471insATCC	uc011khi.1	+	4	3712_3713	c.3174_3175insATCC	c.(3172-3177)GAAATCfs	p.E1058fs		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1058_1059						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TAATTAGTGAAATCCAACCTTT	0.356		NaN								HNSCC(36;0.09)			NaN	NaN	NaN	NaN	NaN	24	93	---	---							
KDM6A	7403	broad.mit.edu	37	X	44969394	44969418	+	Frame_Shift_Del	DEL	AAGATTGTGCACGAAAAACAAGCGG	AAGATTGTGCACGAAAAACAAGCGG	-			TCGA-DK-A1AC-01A-11D-A13W-08	TCGA-DK-A1AC-10A-01D-A13W-08			AAGATTGTGCACGAAAAACAAGCGG	-	AAGATTGTGCACGAAAAACAAGCGG	AAGATTGTGCACGAAAAACAAGCGG		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	a5dc17f5-abda-4534-b0f8-34b59ed4faa3	97693ada-dce8-411a-9d14-8e38af034240	g.chrX:44969394_44969418delAAGATTGTGCACGAAAAACAAGCGG	uc004dge.3	+	28	4451_4475	c.4076_4100delAAGATTGTGCACGAAAAACAAGCGG	c.(4075-4101)CAAGATTGTGCACGAAAAACAAGCGGAfs	p.Q1359fs	KDM6A_uc011mkz.1_Frame_Shift_Del_p.Q1411fs|KDM6A_uc011mla.1_Frame_Shift_Del_p.Q1314fs|KDM6A_uc011mlb.1_Frame_Shift_Del_p.Q1366fs|KDM6A_uc011mlc.1_Frame_Shift_Del_p.Q1063fs|KDM6A_uc011mld.1_Frame_Shift_Del_p.Q998fs	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1359_1367					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						GTACATTGCCAAGATTGTGCACGAAAAACAAGCGGAAACTTGGAA	0.364		NaN	D|N|F|S		renal|oesophageal SCC|MM								NaN	NaN	NaN	NaN	NaN	24	36	---	---