Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
ACAP3	116983	broad.mit.edu	37	1	1235416	1235416	+	Missense_Mutation	SNP	G	G	T	rs147197474	byFrequency	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:1235416G>T	uc001aeb.2	-	8	674	c.600C>A	c.(598-600)TTC>TTA	p.F200L	ACAP3_uc001ady.2_5'Flank|ACAP3_uc001aea.2_Missense_Mutation_p.F158L|ACAP3_uc001aec.1_Missense_Mutation_p.F158L	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	200					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						CCTGCTGGAAGAAGCTGGACT	0.657		NaN											1	0	6.17242e-35	0.01441	6.65509e-35	49	64									
MEGF6	1953	broad.mit.edu	37	1	3425647	3425647	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:3425647T>C	uc001akl.2	-	12	1747	c.1520A>G	c.(1519-1521)GAG>GGG	p.E507G	MEGF6_uc001akk.2_Missense_Mutation_p.E402G	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	507						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		ACCAAACTTCTCTGTGAGCGT	0.672		NaN											0	0	0	0.010729	0	11	29									
CASZ1	54897	broad.mit.edu	37	1	10720282	10720282	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:10720282G>A	uc001aro.2	-	6	1137	c.817C>T	c.(817-819)CTG>TTG	p.L273L	CASZ1_uc001arp.1_Silent_p.L273L|CASZ1_uc009vmx.2_Silent_p.L297L|CASZ1_uc001arq.1_Silent_p.L132L	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	273				L -> P (in Ref. 2; ABB29845).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		AGGCCGGGCAGGGTGCCCACC	0.687		NaN											0	0	0	0.01441	0	110	106									
ARHGEF19	128272	broad.mit.edu	37	1	16532689	16532689	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:16532689C>G	uc001ayc.1	-	7	1421	c.1284G>C	c.(1282-1284)AAG>AAC	p.K428N	ARHGEF19_uc009voo.1_5'UTR|ARHGEF19_uc001ayb.1_5'UTR	NM_153213	NP_694945	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	428	DH.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		CGCTGGTGCTCTTGACCTCGG	0.637		NaN											0	0	0	0.006122	0	17	9									
DHDDS	79947	broad.mit.edu	37	1	26772806	26772806	+	Splice_Site	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:26772806G>A	uc001bml.2	+	5	445	c.324_splice	c.e5-1	p.K108_splice	DHDDS_uc001bmk.2_Splice_Site_p.K108_splice|DHDDS_uc001bmm.2_Splice_Site_p.K15_splice|DHDDS_uc001bmn.2_Intron|DHDDS_uc010ofd.1_Splice_Site_p.K108_splice	NM_205861	NP_995583	Q86SQ9	DHDDS_HUMAN	dehydrodolichyl diphosphate synthase isoform b								protein binding|transferase activity, transferring alkyl or aryl (other than methyl) groups			breast(3)	3		all_cancers(24;2.04e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.0161)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.166)|LUSC - Lung squamous cell carcinoma(448;0.239)		TCCCTGATCAGGGAGAAACTG	0.483		NaN											0	0	0	0.001855	0	13	61									
EPB41	2035	broad.mit.edu	37	1	29438879	29438879	+	Splice_Site	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:29438879G>C	uc001brm.1	+	18	2423	c.2416_splice	c.e18-1	p.T806_splice	EPB41_uc001brg.1_Splice_Site_p.T583_splice|EPB41_uc001brh.1_Splice_Site_p.T530_splice|EPB41_uc001bri.1_Splice_Site_p.T717_splice|EPB41_uc001brj.1_Splice_Site_p.T543_splice|EPB41_uc001brl.1_Splice_Site_p.T773_splice|EPB41_uc009vtl.1_Splice_Site_p.T500_splice|EPB41_uc009vtm.1_Splice_Site_p.T385_splice|EPB41_uc009vtn.1_Splice_Site	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1						blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		TTTGGTTCCAGACTGTAAAAG	0.299		NaN											0	0	0	0.005524	0	35	95									
SFPQ	6421	broad.mit.edu	37	1	35656103	35656103	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:35656103G>A	uc001bys.2	-	4	1504	c.1411C>T	c.(1411-1413)CAA>TAA	p.Q471*	SFPQ_uc001byr.2_RNA	NM_005066	NP_005057	P23246	SFPQ_HUMAN	splicing factor proline/glutamine rich	471					alternative nuclear mRNA splicing, via spliceosome|DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|paraspeckles	DNA binding|nucleotide binding|protein binding|protein binding|RNA binding		SFPQ/TFE3(6)	kidney(4)|soft_tissue(2)|ovary(1)|skin(1)	8		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TCTTACTTTTGATACATTGGA	0.308		NaN	T	TFE3	papillary renal cell								0	0	0	0.00245	0	14	12									
KIAA0319L	79932	broad.mit.edu	37	1	35915495	35915495	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:35915495C>G	uc001byx.2	-	15	2584	c.2326G>C	c.(2326-2328)GAC>CAC	p.D776H	KIAA0319L_uc001byw.2_Missense_Mutation_p.D218H|KIAA0319L_uc010ohv.1_Missense_Mutation_p.D418H	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	776	PKD 5.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTGGTCCGGTCTGTGTCACTC	0.483		NaN											0	0	0	0.009535	0	31	49									
SLC2A1	6513	broad.mit.edu	37	1	43394663	43394663	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:43394663G>A	uc001cik.2	-	8	1539	c.1014C>T	c.(1012-1014)CTC>CTT	p.L338L		NM_006516	NP_006507	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose	338	Helical; Name=9; (Potential).				carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			central_nervous_system(2)|pancreas(2)|ovary(1)	5	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	CGAGGCCTATGAGGTGCAGGG	0.622		NaN											0	0	0	0.01441	0	50	120									
ELAVL4	1996	broad.mit.edu	37	1	50642818	50642818	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:50642818C>T	uc001csb.2	+	3	576	c.308C>T	c.(307-309)GCC>GTC	p.A103V	ELAVL4_uc001cry.3_Missense_Mutation_p.A106V|ELAVL4_uc001crz.3_Missense_Mutation_p.A103V|ELAVL4_uc001csa.3_Missense_Mutation_p.A120V|ELAVL4_uc001csc.3_Missense_Mutation_p.A103V|ELAVL4_uc009vyu.2_Missense_Mutation_p.A108V|ELAVL4_uc010omz.1_Missense_Mutation_p.A108V	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	103	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GCAGAGAAAGCCATCAACACT	0.343		NaN											0	0	0	0.010504	0	19	47									
C1orf177	163747	broad.mit.edu	37	1	55277826	55277826	+	Silent	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:55277826G>C	uc001cyb.3	+	6	780	c.726G>C	c.(724-726)CGG>CGC	p.R242R	C1orf177_uc001cya.3_Silent_p.R242R	NM_001110533	NP_001104003	Q3ZCV2	CA177_HUMAN	hypothetical protein LOC163747 isoform 2	242											0						CTGGTGATCGGAGCAAGCCAC	0.577		NaN											0	0	0	0.004656	0	24	49									
TYW3	127253	broad.mit.edu	37	1	75229767	75229767	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:75229767C>G	uc001dgn.2	+	6	839	c.750C>G	c.(748-750)ATC>ATG	p.I250M	TYW3_uc010oqw.1_Missense_Mutation_p.I217M|TYW3_uc010oqx.1_Missense_Mutation_p.I166M|TYW3_uc010oqy.1_RNA	NM_138467	NP_612476	Q6IPR3	TYW3_HUMAN	tRNA-yW synthesizing protein 3 homolog isoform	250					tRNA processing		methyltransferase activity			ovary(2)	2						ATCTAGGAATCAATGTTACCA	0.348		NaN											0	0	0	0.007413	0	16	178									
AGL	178	broad.mit.edu	37	1	100349714	100349714	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:100349714G>C	uc001dsi.1	+	18	2747	c.2347G>C	c.(2347-2349)GAG>CAG	p.E783Q	AGL_uc001dsj.1_Missense_Mutation_p.E783Q|AGL_uc001dsk.1_Missense_Mutation_p.E783Q|AGL_uc001dsl.1_Missense_Mutation_p.E783Q|AGL_uc001dsm.1_Missense_Mutation_p.E767Q|AGL_uc001dsn.1_Missense_Mutation_p.E766Q	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	783	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TAGAACTATTGAGAGAAACAC	0.328		NaN											0	0	0	0.007835	0	41	36									
CCDC76	54482	broad.mit.edu	37	1	100613733	100613733	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:100613733G>C	uc001dsv.2	+	10	1120	c.1101G>C	c.(1099-1101)ATG>ATC	p.M367I	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	367					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		TCCAGCGAATGAGTAGTTGGG	0.433		NaN											0	0	0	0.011902	0	44	48									
AMY2A	279	broad.mit.edu	37	1	104160108	104160108	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:104160108C>T	uc001dut.2	+	1	110	c.46C>T	c.(46-48)CAG>TAG	p.Q16*	AMY2A_uc010ouq.1_Nonsense_Mutation_p.Q16*	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	16					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	CTGCTGGGCTCAGTATTCCCC	0.398		NaN											0	0	0	0.01441	0	40	160									
OVGP1	5016	broad.mit.edu	37	1	111966266	111966266	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:111966266G>A	uc001eba.2	-	5	438	c.382C>T	c.(382-384)CTG>TTG	p.L128L	OVGP1_uc001eaz.2_Silent_p.L90L|OVGP1_uc010owb.1_5'UTR|OVGP1_uc010owc.1_Silent_p.L118L	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	128					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TGTGTCCTCAGAAGGGATATA	0.433		NaN											0	0	0	0.013114	0	47	48									
ADAM30	11085	broad.mit.edu	37	1	120437228	120437228	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:120437228G>C	uc001eij.2	-	1	1886	c.1732C>G	c.(1732-1734)CAT>GAT	p.H578D		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	578	Cys-rich.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GCCTGTAAATGAGTAGAAATT	0.408		NaN											0	0	0	0.01441	0	76	79									
GPR89A	653519	broad.mit.edu	37	1	145771670	145771670	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:145771670C>T	uc001eot.2	-	11	1144	c.970G>A	c.(970-972)GAG>AAG	p.E324K	NBPF10_uc001emp.3_Intron|GPR89A_uc001eop.2_Missense_Mutation_p.E22K|GPR89A_uc001eoq.2_RNA|GPR89A_uc001eor.2_Missense_Mutation_p.E248K|GPR89A_uc010ozb.1_Missense_Mutation_p.E299K|GPR89A_uc001eos.2_Missense_Mutation_p.E204K|GPR89A_uc010ozc.1_Missense_Mutation_p.E299K|GPR89A_uc010ozd.1_Missense_Mutation_p.E271K|GPR89A_uc010oze.1_Missense_Mutation_p.E324K	NM_001097612	NP_001091081	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A isoform 1	324					intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			ACAGTGATCTCAATGCCTCTT	0.363		NaN											0	0	0	0.003755	0	24	72									
GPR89A	653519	broad.mit.edu	37	1	145771715	145771715	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:145771715C>G	uc001eot.2	-	11	1099	c.925G>C	c.(925-927)GTT>CTT	p.V309L	NBPF10_uc001emp.3_Intron|GPR89A_uc001eop.2_Missense_Mutation_p.V7L|GPR89A_uc001eoq.2_RNA|GPR89A_uc001eor.2_Missense_Mutation_p.V233L|GPR89A_uc010ozb.1_Missense_Mutation_p.V284L|GPR89A_uc001eos.2_Missense_Mutation_p.V189L|GPR89A_uc010ozc.1_Missense_Mutation_p.V284L|GPR89A_uc010ozd.1_Missense_Mutation_p.V256L|GPR89A_uc010oze.1_Missense_Mutation_p.V309L	NM_001097612	NP_001091081	B7ZAQ6	GPHRA_HUMAN	G protein-coupled receptor 89A isoform 1	309	Helical; (Potential).				intracellular pH reduction|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein transport	Golgi cisterna membrane|Golgi-associated vesicle membrane|integral to membrane	signal transducer activity|voltage-gated anion channel activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			CGATCAAAAACAATATTGATG	0.353		NaN											0	0	0	0.005443	0	21	60									
ARNT	405	broad.mit.edu	37	1	150795814	150795814	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:150795814T>C	uc001evr.1	-	14	1393	c.1250A>G	c.(1249-1251)AAA>AGA	p.K417R	ARNT_uc001evs.1_Missense_Mutation_p.K402R|ARNT_uc009wmb.1_Missense_Mutation_p.K403R|ARNT_uc009wmc.1_Missense_Mutation_p.K417R|ARNT_uc009wmd.1_Missense_Mutation_p.K402R|ARNT_uc009wme.1_Intron|ARNT_uc010pcl.1_Missense_Mutation_p.K401R	NM_001668	NP_001659	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	417	PAS 2.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			skin(4)|lung(3)|central_nervous_system(1)|kidney(1)	9	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			GCCTTTTAATTTCACTACCTG	0.368		NaN	T	ETV6	AML								0	0	0	0.01441	0	69	61									
C1orf56	54964	broad.mit.edu	37	1	151022921	151022921	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:151022921G>A	uc001ewn.2	+	2	1078	c.1013G>A	c.(1012-1014)AGA>AAA	p.R338K		NM_017860	NP_060330	Q9BUN1	CA056_HUMAN	hypothetical protein LOC54964 precursor	338						extracellular region					0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGATAGACAGAAACCAGAGG	0.413		NaN											0	0	0	0.004878	0	34	133									
FLG	2312	broad.mit.edu	37	1	152276031	152276031	+	Silent	SNP	C	C	T	rs147295587	by1000genomes	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:152276031C>T	uc001ezu.1	-	3	11367	c.11331G>A	c.(11329-11331)TCG>TCA	p.S3777S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3777	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTATCTACCGATTGCTCGT	0.587		NaN							Ichthyosis				0	0	0	0.01441	0	140	467									
FLG	2312	broad.mit.edu	37	1	152277865	152277865	+	Missense_Mutation	SNP	C	C	T	rs145566935		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:152277865C>T	uc001ezu.1	-	3	9533	c.9497G>A	c.(9496-9498)CGT>CAT	p.R3166H		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3166	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTCATTACGTGTTGTTCT	0.552		NaN							Ichthyosis				0	0	0	0.01441	0	103	360									
CRTC2	200186	broad.mit.edu	37	1	153920995	153920995	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:153920995G>A	uc010ped.1	-	13	1870	c.1800C>T	c.(1798-1800)TTC>TTT	p.F600F	DENND4B_uc001fdd.1_5'Flank|CRTC2_uc001fde.3_RNA|CRTC2_uc001fdf.3_Silent_p.F136F	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	600					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TCTGGTGGTTGAAGGTGTGGG	0.592		NaN											0	0	0	0.01441	0	116	109									
INSRR	3645	broad.mit.edu	37	1	156823546	156823546	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:156823546C>G	uc010pht.1	-	2	889	c.635G>C	c.(634-636)AGA>ACA	p.R212T	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Missense_Mutation_p.R212T	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	212					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTGCCCACCTCTCTGGCAGTG	0.607		NaN											0	0	0	0.00874	0	35	132									
CRP	1401	broad.mit.edu	37	1	159683510	159683510	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:159683510G>A	uc001ftw.2	-	2	584	c.480C>T	c.(478-480)TTC>TTT	p.F160F	CRP_uc001ftx.1_Intron|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	160	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	AGTTCCCACCGAAGGAATCCT	0.517		NaN											0	0	0	0.01441	0	116	250									
C1orf114	57821	broad.mit.edu	37	1	169394120	169394120	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:169394120C>T	uc001gga.1	-	2	214	c.46G>A	c.(46-48)GAA>AAA	p.E16K	C1orf114_uc001gfz.1_Missense_Mutation_p.E16K|C1orf114_uc009wvq.1_Missense_Mutation_p.E16K|C1orf114_uc001ggb.2_Missense_Mutation_p.E16K|C1orf114_uc001ggc.1_Missense_Mutation_p.E16K	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	16											0	all_hematologic(923;0.208)					AAGTCATCTTCGTATTCTTCA	0.289		NaN											0	0	0	0.008871	0	17	43									
F5	2153	broad.mit.edu	37	1	169511937	169511937	+	Silent	SNP	G	G	C	rs139113111		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:169511937G>C	uc001ggg.1	-	13	2536	c.2391C>G	c.(2389-2391)GCC>GCG	p.A797A		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	797	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GGTGAGAAGGGGCTTTCTGAG	0.433		NaN											0	0	0	0.00874	0	41	114									
LAMC1	3915	broad.mit.edu	37	1	183096378	183096378	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:183096378G>A	uc001gpy.3	+	17	3219	c.2962G>A	c.(2962-2964)GAG>AAG	p.E988K		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	988	Laminin EGF-like 11.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGTCATCCTGAGGGATCTCT	0.378		NaN											0	0	0	0.001855	0	13	36									
CNTN2	6900	broad.mit.edu	37	1	205042279	205042279	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:205042279C>T	uc001hbr.2	+	22	3197	c.2928C>T	c.(2926-2928)GAC>GAT	p.D976D	CNTN2_uc001hbs.2_Silent_p.D764D	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	976	Fibronectin type-III 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TGCCTGAAGACATTGGCCATG	0.567		NaN											0	0	0	0.008361	0	30	40									
RAB3GAP2	25782	broad.mit.edu	37	1	220364531	220364531	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:220364531G>A	uc010puk.1	-	14	1530	c.1366C>T	c.(1366-1368)CAG>TAG	p.Q456*	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Nonsense_Mutation_p.Q36*	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	456					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		CTTGGACCCTGAGAATTTCCA	0.478		NaN											0	0	0	0.00632	0	28	51									
KIAA1804	84451	broad.mit.edu	37	1	233489599	233489599	+	Missense_Mutation	SNP	C	C	T	rs145103476		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:233489599C>T	uc001hvt.3	+	3	1294	c.1033C>T	c.(1033-1035)CGG>TGG	p.R345W	KIAA1804_uc001hvs.1_Missense_Mutation_p.R345W	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	345	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				AGTCCCCTATCGGGGCATTGA	0.507		NaN											0	0	0	0.006122	0	19	77									
RYR2	6262	broad.mit.edu	37	1	237813229	237813229	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:237813229C>T	uc001hyl.1	+	50	7685	c.7565C>T	c.(7564-7566)ACA>ATA	p.T2522I		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2522	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TACCTTTGCACAGCCGTCTTG	0.463		NaN											0	0	0	0.010771	0	43	133									
ZP4	57829	broad.mit.edu	37	1	238053778	238053778	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:238053778G>A	uc001hym.2	-	1	158	c.158C>T	c.(157-159)CCT>CTT	p.P53L	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	53	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TATTAGTACAGGAGGAGACGT	0.488		NaN											0	0	0	0.013537	0	10	48									
ADSS	159	broad.mit.edu	37	1	244582145	244582145	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:244582145G>C	uc001iaj.2	-	9	1156	c.862C>G	c.(862-864)CAA>GAA	p.Q288E		NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	288					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CCAACATTTTGAGGTGGCATA	0.378		NaN											0	0	0	0.006214	0	9	31									
TUBB8	347688	broad.mit.edu	37	10	93965	93965	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:93965C>G	uc001ifi.2	-	4	367	c.367G>C	c.(367-369)GAG>CAG	p.E123Q	TUBB8_uc009xhe.2_Missense_Mutation_p.E86Q|TUBB8_uc010pzs.1_Missense_Mutation_p.E51Q	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	123					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		CTCTCAGCCTCCTTTCTGACA	0.597		NaN											0	0	0	0.004007	0	12	167									
FRMD4A	55691	broad.mit.edu	37	10	13698803	13698803	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:13698803C>T	uc001ims.2	-	22	3138	c.2786G>A	c.(2785-2787)CGC>CAC	p.R929H	FRMD4A_uc009xjf.1_Missense_Mutation_p.R929H	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	929						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GTACCACTGGCGCAGCTCGTC	0.711		NaN											0	0	0	0.010729	0	10	72									
ZNF33B	7582	broad.mit.edu	37	10	43088106	43088106	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:43088106G>A	uc001jaf.1	-	5	2407	c.2292C>T	c.(2290-2292)CTC>CTT	p.L764L	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Silent_p.L652L|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	764	C2H2-type 16.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GATGTACAATGAGATTTGACT	0.393		NaN											0	0	0	0.009535	0	30	229									
MYPN	84665	broad.mit.edu	37	10	69925571	69925571	+	Silent	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:69925571G>C	uc001jnm.3	+	10	1781	c.1596G>C	c.(1594-1596)GTG>GTC	p.V532V	MYPN_uc001jnl.1_Silent_p.V532V|MYPN_uc001jnn.3_Silent_p.V257V|MYPN_uc001jno.3_Silent_p.V532V|MYPN_uc009xps.2_Silent_p.V532V|MYPN_uc009xpt.2_Silent_p.V532V|MYPN_uc010qit.1_Silent_p.V238V|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	532						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						AGCTGCACGTGAGAGGTAAGG	0.428		NaN											0	0	0	0.014323	0	18	117									
DDX21	9188	broad.mit.edu	37	10	70738718	70738718	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:70738718C>G	uc001jov.1	+	13	2113	c.2023C>G	c.(2023-2025)CTC>GTC	p.L675V	DDX21_uc001jow.1_Missense_Mutation_p.L607V	NM_004728	NP_004719	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	675						nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)	3						AATGGTTTTTCTCAAAGGAAA	0.458		NaN											0	0	0	0.003755	0	32	150									
USP54	159195	broad.mit.edu	37	10	75279710	75279710	+	Silent	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:75279710C>A	uc001juo.2	-	17	2540	c.2523G>T	c.(2521-2523)ACG>ACT	p.T841T	USP54_uc010qkk.1_Silent_p.T23T|USP54_uc001juk.2_Intron|USP54_uc001jul.2_Intron|USP54_uc001jum.2_Intron|USP54_uc001jun.2_Intron|USP54_uc001jup.2_Silent_p.T841T	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	841					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					CTCTGCTGTGCGTGCTACAGC	0.378		NaN											1	0	2.56e-06	0.009096	2.61753e-06	4	45									
KIAA0913	23053	broad.mit.edu	37	10	75548903	75548903	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:75548903G>A	uc009xrl.2	+	3	444	c.412G>A	c.(412-414)GAT>AAT	p.D138N	KIAA0913_uc001jve.2_Missense_Mutation_p.D138N|KIAA0913_uc001jvf.2_Missense_Mutation_p.D138N|KIAA0913_uc001jvh.2_5'Flank|KIAA0913_uc001jvi.2_5'Flank|KIAA0913_uc010qkr.1_5'Flank|KIAA0913_uc001jvj.2_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	138							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					TCAGCGAGGGGATCAGCTCTT	0.567		NaN											0	0	0	0.01441	0	65	67									
LRIT1	26103	broad.mit.edu	37	10	85992365	85992365	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:85992365G>C	uc001kcz.1	-	4	1212	c.1190C>G	c.(1189-1191)TCT>TGT	p.S397C		NM_015613	NP_056428	Q9P2V4	LRIT1_HUMAN	retina specific protein PAL	397	Lumenal (Potential).					integral to endoplasmic reticulum membrane					0						GCTGGGCACAGAGGGTCCAGT	0.617		NaN											0	0	0	0.004878	0	36	109									
GRID1	2894	broad.mit.edu	37	10	87373287	87373287	+	Silent	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:87373287G>C	uc001kdl.1	-	15	2579	c.2478C>G	c.(2476-2478)CTC>CTG	p.L826L	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.L397L	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	826	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TGTGCAGCTTGAGGGATTTGC	0.647		NaN								Multiple Myeloma(13;0.14)			0	0	0	0.010504	0	19	100									
CH25H	9023	broad.mit.edu	37	10	90966884	90966884	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:90966884C>T	uc001kfz.2	-	1	188	c.166G>A	c.(166-168)GTG>ATG	p.V56M		NM_003956	NP_003947	O95992	CH25H_HUMAN	cholesterol 25-hydroxylase	56	Helical; (Potential).				bile acid biosynthetic process|fatty acid biosynthetic process|sterol biosynthetic process	cytosol|endoplasmic reticulum membrane|integral to membrane	cholesterol 25-hydroxylase activity|iron ion binding				0		Colorectal(252;0.0161)		GBM - Glioblastoma multiforme(2;0.000133)		TCCAGGACCACGAAGGGCAGG	0.632		NaN											0	0	0	0.004007	0	15	53									
SLIT1	6585	broad.mit.edu	37	10	98762697	98762697	+	Silent	SNP	G	G	A	rs148583876		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:98762697G>A	uc001kmw.2	-	35	4170	c.3918C>T	c.(3916-3918)AAC>AAT	p.N1306N		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1306	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		AGCCGGTGCCGTTGAGGATCT	0.607		NaN											0	0	0	0.01441	0	69	331									
SLIT1	6585	broad.mit.edu	37	10	98823297	98823297	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:98823297G>A	uc001kmw.2	-	8	960	c.708C>T	c.(706-708)ATC>ATT	p.I236I	SLIT1_uc009xvh.1_Silent_p.I236I	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	236	LRRCT 1.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TGAAGAGCCCGATGGTTGGCC	0.647		NaN											0	0	0	0.009535	0	28	21									
PNLIPRP3	119548	broad.mit.edu	37	10	118236220	118236220	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:118236220T>C	uc001lcl.3	+	11	1330	c.1229T>C	c.(1228-1230)GTT>GCT	p.V410A		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	410	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		GATGTTAACGTTGGAAACATT	0.358		NaN											0	0	0	0.01441	0	59	60									
PNLIPRP3	119548	broad.mit.edu	37	10	118236306	118236306	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:118236306A>C	uc001lcl.3	+	11	1416	c.1315A>C	c.(1315-1317)AAT>CAT	p.N439H		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	439	PLAT.				lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AATGGTGATAAATACATCTGG	0.308		NaN											0	0	0	0.010771	0	41	46									
C11orf35	256329	broad.mit.edu	37	11	558000	558000	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:558000G>A	uc001lpx.2	-	5	502	c.439C>T	c.(439-441)CGC>TGC	p.R147C	uc001lpy.2_RNA|uc001lpz.2_5'Flank|RASSF7_uc001lqa.2_5'Flank|RASSF7_uc001lqb.2_5'Flank	NM_173573	NP_775844	Q8IXW0	CK035_HUMAN	hypothetical protein LOC256329	147	Potential.									pancreas(1)	1		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGAGCGTGCGGGTGGTCTGC	0.672		NaN											0	0	0	0.01441	0	60	63									
OR52N4	390072	broad.mit.edu	37	11	5776753	5776753	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:5776753C>G	uc001mbu.2	+	1	831	c.783C>G	c.(781-783)TTC>TTG	p.F261L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TCTTCTCCTTCTTTTCCCACC	0.478		NaN											0	0	0	0.007291	0	29	72									
STK33	65975	broad.mit.edu	37	11	8457652	8457652	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:8457652C>T	uc001mgi.1	-	9	1901	c.982G>A	c.(982-984)GAA>AAA	p.E328K	STK33_uc001mgj.1_Missense_Mutation_p.E328K|STK33_uc001mgk.1_Missense_Mutation_p.E328K|STK33_uc010rbn.1_Missense_Mutation_p.E287K|STK33_uc001mgl.3_Missense_Mutation_p.E141K|STK33_uc009yfp.2_Missense_Mutation_p.E50K	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	328	Protein kinase.					Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		AGCTTCTCTTCTGAGCTTGCC	0.308		NaN											0	0	0	0.008871	0	19	31									
STK33	65975	broad.mit.edu	37	11	8496434	8496434	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:8496434C>G	uc001mgi.1	-	1	938	c.19G>C	c.(19-21)GAT>CAT	p.D7H	STK33_uc001mgj.1_Missense_Mutation_p.D7H|STK33_uc001mgk.1_Missense_Mutation_p.D7H|STK33_uc010rbn.1_Intron|STK33_uc001mgl.3_Intron|STK33_uc009yfp.2_Intron	NM_030906	NP_112168	Q9BYT3	STK33_HUMAN	serine/threonine kinase 33	7						Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|pancreas(1)|central_nervous_system(1)|skin(1)	7				Epithelial(150;2.13e-06)|BRCA - Breast invasive adenocarcinoma(625;0.239)		GATTTTTTATCTAAGCCACTA	0.393		NaN											0	0	0	0.003954	0	24	57									
KCNJ11	3767	broad.mit.edu	37	11	17409306	17409306	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:17409306G>A	uc001mna.2	-	1	901	c.333C>T	c.(331-333)GTC>GTT	p.V111V	KCNJ11_uc001mnb.3_Silent_p.V24V	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	111						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		GGATGCTGGTGACACAGGGCT	0.622		NaN											0	0	0	0.013726	0	32	51									
QSER1	79832	broad.mit.edu	37	11	32997931	32997931	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:32997931C>T	uc001mty.2	+	13	5386	c.5119C>T	c.(5119-5121)CAA>TAA	p.Q1707*	QSER1_uc001mtz.1_Nonsense_Mutation_p.Q1468*	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1707										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					GGAAATTGTTCAACTTTGTAT	0.318		NaN											0	0	0	0.007413	0	19	32									
ACCS	84680	broad.mit.edu	37	11	44089398	44089398	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:44089398G>A	uc009yks.1	+	2	365	c.221G>A	c.(220-222)TGG>TAG	p.W74*	ACCS_uc010rfm.1_Intron|ACCS_uc010rfn.1_Nonsense_Mutation_p.W74*|ACCS_uc001mxx.2_Nonsense_Mutation_p.W74*	NM_001127219	NP_001120691	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase	74							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(2)|ovary(1)|lung(1)	4						AAATGGTTCTGGGATTCAGCT	0.537		NaN											0	0	0	0.004656	0	28	37									
MAPK8IP1	9479	broad.mit.edu	37	11	45924153	45924153	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:45924153G>A	uc001nbr.2	+	5	1005	c.835G>A	c.(835-837)GAG>AAG	p.E279K		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	279	JNK-binding domain (JBD).				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		AGAGGCCACTGAGGAGATCTA	0.682		NaN											0	0	0	0.004289	0	37	70									
HARBI1	283254	broad.mit.edu	37	11	46637415	46637415	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:46637415C>T	uc001ncy.2	-	2	621	c.373G>A	c.(373-375)GAA>AAA	p.E125K	KIAA0652_uc009yld.2_5'Flank|KIAA0652_uc001nda.2_5'Flank|KIAA0652_uc001ndb.2_5'Flank|KIAA0652_uc001ncz.2_5'Flank|KIAA0652_uc001ndc.2_5'Flank|KIAA0652_uc010rgv.1_5'Flank	NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	125						cytoplasm|nucleus	metal ion binding|nuclease activity				0						ATGGAGGCTTCATCAGCTGGA	0.522		NaN											0	0	0	0.01441	0	134	230									
P2RX3	5024	broad.mit.edu	37	11	57106039	57106039	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:57106039C>T	uc001nju.2	+	1	91	c.15C>T	c.(13-15)TCC>TCT	p.S5S	SSRP1_uc001njt.2_5'Flank	NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	5	Cytoplasmic (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						ACTGCATATCCGACTTCTTCA	0.542		NaN											0	0	0	0.01441	0	129	273									
DAGLA	747	broad.mit.edu	37	11	61487650	61487650	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:61487650G>A	uc001nsa.2	+	2	134	c.23G>A	c.(22-24)CGG>CAG	p.R8Q		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	8	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GTGGTGTTCCGGCGGCGCTGG	0.632		NaN											0	0	0	0.01441	0	52	96									
SLC22A12	116085	broad.mit.edu	37	11	64360266	64360266	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:64360266G>C	uc001oam.1	+	2	1165	c.418G>C	c.(418-420)GAC>CAC	p.D140H	SLC22A12_uc009ypr.1_Missense_Mutation_p.D140H|SLC22A12_uc001oal.1_5'UTR|SLC22A12_uc009yps.1_Missense_Mutation_p.D140H|SLC22A12_uc001oan.1_Missense_Mutation_p.D140H|SLC22A12_uc009ypt.2_5'Flank	NM_144585	NP_653186	Q96S37	S22AC_HUMAN	urate anion exchanger 1 isoform a	140					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			ovary(1)	1						CCTCGTGTGTGACTCTCATGC	0.642		NaN											0	0	0	0.01441	0	96	397									
CD248	57124	broad.mit.edu	37	11	66083610	66083610	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:66083610G>A	uc001ohm.1	-	1	906	c.889C>T	c.(889-891)CGC>TGC	p.R297C		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	297	Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	AAACCCAGGCGACAGTGGCAG	0.647		NaN											0	0	0	0.01441	0	61	62									
RBM14	10432	broad.mit.edu	37	11	66392969	66392969	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:66392969G>A	uc001oit.2	+	2	1761	c.1622G>A	c.(1621-1623)CGC>CAC	p.R541H	RBM14_uc009yrh.2_Intron|RBM14_uc009yri.2_Intron|RBM4_uc009yrj.2_Intron|RBM4_uc009yrk.2_Intron	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	541	Ala-rich.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						GCCTCCTACCGCGGCCAGCCA	0.657		NaN											0	0	0	0.006122	0	14	110									
RBM4	5936	broad.mit.edu	37	11	66407491	66407491	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:66407491G>A	uc009yrj.2	+	2	797	c.309G>A	c.(307-309)CCG>CCA	p.P103P	RBM4_uc009yrk.2_Intron|RBM4_uc001oiv.2_Silent_p.P103P|RBM4_uc001oiw.1_Silent_p.P103P|RBM4_uc001oix.1_Silent_p.P103P|RBM4_uc010rpj.1_Silent_p.P103P|RBM4_uc001oiy.1_Silent_p.P103P|RBM4_uc001oiz.1_Silent_p.P103P	NM_002896	NP_002887	Q9BWF3	RBM4_HUMAN	RNA binding motif protein 4	103	RRM 2.				circadian regulation of gene expression|entrainment of circadian clock by photoperiod|mRNA processing|negative regulation of translation in response to stress|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|positive regulation of muscle cell differentiation|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of nucleocytoplasmic transport|RNA splicing|stress-activated MAPK cascade	nuclear speck|nucleolus|stress granule	miRNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|zinc ion binding			ovary(1)	1				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		AGTATGGTCCGGTCATCGAAT	0.498		NaN											0	0	0	0.01441	0	187	118									
SUV420H1	51111	broad.mit.edu	37	11	67934619	67934619	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:67934619C>G	uc001onm.1	-	10	1260	c.1004G>C	c.(1003-1005)AGA>ACA	p.R335T	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_Missense_Mutation_p.R163T|SUV420H1_uc009ysf.2_Missense_Mutation_p.R95T|SUV420H1_uc001ono.1_Missense_Mutation_p.R335T|SUV420H1_uc001onp.2_Missense_Mutation_p.R335T|SUV420H1_uc010rqa.1_Missense_Mutation_p.R312T|SUV420H1_uc001onq.2_Missense_Mutation_p.R335T	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CAGTCCCACTCTGGATTTAAA	0.408		NaN											0	0	0	0.006214	0	9	76									
FGF3	2248	broad.mit.edu	37	11	69631101	69631101	+	Missense_Mutation	SNP	C	C	T	rs150581924	by1000genomes	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:69631101C>T	uc001oph.2	-	2	802	c.311G>A	c.(310-312)CGA>CAA	p.R104Q		NM_005247	NP_005238	P11487	FGF3_HUMAN	fibroblast growth factor 3 precursor	104					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of cardiac muscle tissue development|positive regulation of cell division|positive regulation of cell proliferation	extracellular region	growth factor activity			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(11;5.05e-15)|STAD - Stomach adenocarcinoma(18;0.0278)			AGCATAGAGTCGTCCCCTCTT	0.597		NaN											0	0	0	0.01441	0	62	888									
USP35	57558	broad.mit.edu	37	11	77907438	77907438	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:77907438C>T	uc009yva.1	+	2	393	c.147C>T	c.(145-147)TAC>TAT	p.Y49Y	USP35_uc001oze.2_Intron|USP35_uc001ozc.2_Intron|USP35_uc010rsp.1_Intron|USP35_uc001ozd.2_Translation_Start_Site|USP35_uc001ozf.2_5'Flank	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	49					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			CGCGCCTCTACGTGGGCGGCG	0.766		NaN											0	0	0	0.006214	0	8	57									
MRE11A	4361	broad.mit.edu	37	11	94194101	94194101	+	Splice_Site	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:94194101C>G	uc001peu.2	-	12	1515	c.1326_splice	c.e12+1	p.K442_splice	MRE11A_uc001pev.2_Splice_Site_p.K442_splice|MRE11A_uc009ywj.2_Splice_Site_p.K445_splice	NM_005591	NP_005582	P49959	MRE11_HUMAN	meiotic recombination 11 homolog A isoform 1						DNA duplex unwinding|double-strand break repair via homologous recombination|double-strand break repair via nonhomologous end joining|negative regulation of DNA endoreduplication|positive regulation of kinase activity|positive regulation of protein autophosphorylation|reciprocal meiotic recombination|regulation of mitotic recombination|sister chromatid cohesion|telomere maintenance via telomerase	Mre11 complex|nucleoplasm	3'-5' exonuclease activity|double-stranded DNA binding|manganese ion binding|protein C-terminus binding|single-stranded DNA specific endodeoxyribonuclease activity			breast(4)|lung(1)	5		Acute lymphoblastic leukemia(157;2.37e-05)|all_hematologic(158;0.00824)				TAAGAAATTACCTTCTCTGCG	0.318		NaN						Homologous_recombination	Ataxia-Telangiectasia-Like_Disorder				0	0	0	0.001984	0	7	15									
EXPH5	23086	broad.mit.edu	37	11	108384189	108384189	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:108384189G>A	uc001pkk.2	-	6	2156	c.2045C>T	c.(2044-2046)TCT>TTT	p.S682F	EXPH5_uc010rvy.1_Missense_Mutation_p.S494F|EXPH5_uc010rvz.1_Missense_Mutation_p.S526F|EXPH5_uc010rwa.1_Missense_Mutation_p.S606F	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	682					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AAGAGGCAGAGAGTCAACTGA	0.413		NaN											0	0	0	0.013726	0	32	45									
TECTA	7007	broad.mit.edu	37	11	121008294	121008294	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:121008294T>G	uc010rzo.1	+	10	3106	c.3106T>G	c.(3106-3108)TGT>GGT	p.C1036G		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1036	TIL 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCGGAGTGAGTGTGGCTGCAA	0.572		NaN											0	0	0	0.008871	0	17	32									
EFCAB4B	84766	broad.mit.edu	37	12	3806003	3806003	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:3806003C>A	uc001qmj.2	-	4	735	c.163G>T	c.(163-165)GCA>TCA	p.A55S	EFCAB4B_uc010sen.1_Missense_Mutation_p.A55S|EFCAB4B_uc010seo.1_Missense_Mutation_p.A55S	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	55	EF-hand 1.				activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			AACTCCTGTGCCTTCCTCAGC	0.597		NaN											1	0	0.000175454	0.010504	0.000177404	18	82									
ANO2	57101	broad.mit.edu	37	12	5848494	5848494	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:5848494C>T	uc001qnm.2	-	13	1483	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	476	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						TCTTCCTCTTCTATGCCAGTC	0.433		NaN											0	0	0	0.004672	0	3	13									
A2ML1	144568	broad.mit.edu	37	12	9004565	9004565	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:9004565G>A	uc001quz.3	+	19	2518	c.2420G>A	c.(2419-2421)CGT>CAT	p.R807H	A2ML1_uc001qva.1_Missense_Mutation_p.R387H|A2ML1_uc010sgm.1_Missense_Mutation_p.R307H	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	651						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						GAATCCTTTCGTCTTACTGCC	0.507		NaN											0	0	0	0.007835	0	41	173									
ETV6	2120	broad.mit.edu	37	12	12022825	12022825	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:12022825G>A	uc001qzz.2	+	5	1205	c.931G>A	c.(931-933)GAC>AAC	p.D311N	ETV6_uc001raa.1_Missense_Mutation_p.D104N	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	311						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				TCATCGGGAAGACCTGGCTTA	0.582		NaN	T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								0	0	0	0.01441	0	81	116									
ETV6	2120	broad.mit.edu	37	12	12022873	12022873	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:12022873G>C	uc001qzz.2	+	5	1253	c.979G>C	c.(979-981)GAG>CAG	p.E327Q	ETV6_uc001raa.1_Missense_Mutation_p.E120Q	NM_001987	NP_001978	P41212	ETV6_HUMAN	ets variant 6	327						cytoplasm|nucleolus	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		ETV6/NTRK3(234)|ETV6/JAK2(11)	soft_tissue(85)|kidney(66)|breast(55)|salivary_gland(26)|haematopoietic_and_lymphoid_tissue(13)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)|pancreas(1)	250		all_cancers(2;1.88e-12)|Acute lymphoblastic leukemia(2;6.91e-39)|all_hematologic(2;2.7e-36)				CCCGCCTGAAGAGCACGCCAT	0.582		NaN	T	NTRK3|RUNX1|PDGFRB|ABL1|MN1|ABL2|FACL6|CHIC2|ARNT|JAK2|EVI1|CDX2|STL|HLXB9|MDS2|PER1|SYK|TTL|FGFR3|PAX5	congenital fibrosarcoma|multiple leukemia and lymphoma| secretory breast|MDS|ALL								0	0	0	0.01441	0	68	86									
LOH12CR1	118426	broad.mit.edu	37	12	12514236	12514236	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:12514236A>T	uc001ral.2	+	2	521	c.155A>T	c.(154-156)GAT>GTT	p.D52V	LOH12CR1_uc009zhu.2_Intron	NM_058169	NP_477517	Q969J3	L12R1_HUMAN	LOH1CR12	52										ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		AACGATCCCGATGTCATCAAG	0.488		NaN											0	0	0	0.012213	0	35	230									
GALNT6	11226	broad.mit.edu	37	12	51757940	51757940	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:51757940C>T	uc001ryk.2	-	5	1239	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Silent_p.E338E	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	338	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GCCTCTGCTTCTCATGTGGAG	0.587		NaN											0	0	0	0.01441	0	64	105									
OR6C6	283365	broad.mit.edu	37	12	55688992	55688992	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:55688992C>G	uc010sph.1	-	1	25	c.25G>C	c.(25-27)GAG>CAG	p.E9Q		NM_001005493	NP_001005493	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|skin(1)	2						AGAATGAACTCTATTTCCATT	0.318		NaN											0	0	0	0.014323	0	19	46									
MBD6	114785	broad.mit.edu	37	12	57921371	57921371	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:57921371C>G	uc001soj.1	+	8	2388	c.2164C>G	c.(2164-2166)CTG>GTG	p.L722V	MBD6_uc001sok.1_Missense_Mutation_p.L589V|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	722	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						GGCCTCCTCTCTGGGCAAGGC	0.597		NaN											0	0	0	0.01441	0	218	346									
MON2	23041	broad.mit.edu	37	12	62929388	62929388	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:62929388C>T	uc001sre.2	+	14	2190	c.1799C>T	c.(1798-1800)TCA>TTA	p.S600L	MON2_uc009zqj.2_Missense_Mutation_p.S600L|MON2_uc010ssl.1_Missense_Mutation_p.S528L|MON2_uc010ssm.1_Missense_Mutation_p.S600L|MON2_uc010ssn.1_Missense_Mutation_p.S600L|MON2_uc001srf.2_Missense_Mutation_p.S363L	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	600					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CTTGTAACTTCAAGAGATGCC	0.413		NaN											0	0	0	0.01441	0	55	63									
EEA1	8411	broad.mit.edu	37	12	93258690	93258690	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:93258690T>C	uc001tck.2	-	3	456	c.191A>G	c.(190-192)CAT>CGT	p.H64R		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	64	C2H2-type.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						ACCAGCATCATGAACAGCTTC	0.378		NaN											0	0	0	0.010818	0	33	61									
C12orf63	374467	broad.mit.edu	37	12	97051735	97051735	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:97051735C>G	uc001tet.1	+	4	529	c.451C>G	c.(451-453)CTT>GTT	p.L151V		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	151										skin(6)|ovary(1)	7						TGGTTCTAGTCTTACCTTTGA	0.353		NaN											0	0	0	0.007835	0	38	145									
C12orf63	374467	broad.mit.edu	37	12	97051869	97051869	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:97051869C>T	uc001tet.1	+	4	663	c.585C>T	c.(583-585)TTC>TTT	p.F195F		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	195										skin(6)|ovary(1)	7						CCATTCAGTTCAATACAGTTT	0.303		NaN											0	0	0	0.010729	0	10	50									
PAH	5053	broad.mit.edu	37	12	103288533	103288533	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:103288533C>T	uc001tjq.1	-	4	804	c.332G>A	c.(331-333)CGA>CAA	p.R111Q	PAH_uc010swc.1_Missense_Mutation_p.R111Q	NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	111					catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	CTTCTTATCTCGTGAAAGCTC	0.383		NaN											0	0	0	0.006122	0	18	67									
PRDM4	11108	broad.mit.edu	37	12	108147715	108147715	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:108147715C>G	uc001tmp.2	-	4	754	c.317G>C	c.(316-318)AGA>ACA	p.R106T	PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	106					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TAGAATGGTTCTGAAATAACT	0.433		NaN											0	0	0	0.011902	0	42	68									
ACAD10	80724	broad.mit.edu	37	12	112182844	112182844	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:112182844C>T	uc001tsq.2	+	13	2312	c.2112C>T	c.(2110-2112)CTC>CTT	p.L704L	ACAD10_uc001tsp.2_Silent_p.L704L|ACAD10_uc009zvx.2_Silent_p.L735L|ACAD10_uc001tss.1_RNA	NM_025247	NP_079523	Q6JQN1	ACD10_HUMAN	acyl-Coenzyme A dehydrogenase family, member 10	704							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups			ovary(2)	2						TCGAAGACCTCAAGGTAAAGC	0.592		NaN											0	0	0	0.00632	0	29	84									
C12orf51	283450	broad.mit.edu	37	12	112681690	112681690	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:112681690C>T	uc009zwc.2	-	23	3389	c.3371G>A	c.(3370-3372)AGA>AAA	p.R1124K		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CTGATTTGCTCTAGTAAATTC	0.458		NaN											0	0	0	0.01441	0	47	171									
C12orf51	283450	broad.mit.edu	37	12	112685315	112685315	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:112685315C>T	uc009zwc.2	-	21	3040	c.3022G>A	c.(3022-3024)GAA>AAA	p.E1008K		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						AAGGAGACTTCCTTCATTGAA	0.318		NaN											0	0	0	0.001168	0	4	7									
TPCN1	53373	broad.mit.edu	37	12	113705698	113705698	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:113705698C>T	uc001tuw.2	+	5	762	c.465C>T	c.(463-465)CTC>CTT	p.L155L	TPCN1_uc001tux.2_Silent_p.L227L|TPCN1_uc010syt.1_Silent_p.L87L	NM_017901	NP_060371	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1 isoform 2	155	Helical; Name=S2 of repeat I; (Potential).					endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			skin(2)|ovary(1)	3						TGTTTGAACTCTGCATGAAGT	0.607		NaN											0	0	0	0.016522	0	23	37									
UBC	7316	broad.mit.edu	37	12	125396365	125396365	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:125396365C>T	uc001ugs.3	-	2	2401	c.1953G>A	c.(1951-1953)TTG>TTA	p.L651L	UBC_uc001ugr.2_RNA|UBC_uc001ugu.1_Silent_p.L575L|UBC_uc001ugt.2_Silent_p.L499L|UBC_uc001ugv.2_Silent_p.L119L	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	651	Ubiquitin-like 9.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CAGCAAAGATCAACCTCTGCT	0.537		NaN											0	0	0	0.01441	0	123	477									
DHX37	57647	broad.mit.edu	37	12	125461982	125461982	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:125461982C>T	uc001ugy.2	-	5	892	c.793G>A	c.(793-795)GTG>ATG	p.V265M		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	265	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TGCTCGGCCACAGCCTCCATG	0.552		NaN											0	0	0	0.01441	0	148	144									
SFRS8	6433	broad.mit.edu	37	12	132203998	132203998	+	Splice_Site	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:132203998G>C	uc001uja.1	+	4	661	c.521_splice	c.e4-1	p.E174_splice	SFRS8_uc010tbn.1_Splice_Site_p.E174_splice|SFRS8_uc001ujb.1_Splice_Site|SFRS8_uc001uiz.1_Splice_Site_p.E48_splice	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8						mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		TTTTTATGCAGAAAAAAATGA	0.468		NaN											0	0	0	0.01441	0	52	81									
EP400	57634	broad.mit.edu	37	12	132502160	132502160	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:132502160C>T	uc001ujn.2	+	19	4039	c.4004C>T	c.(4003-4005)CCT>CTT	p.P1335L	EP400_uc001ujl.2_Missense_Mutation_p.P1334L|EP400_uc001ujm.2_Missense_Mutation_p.P1335L	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1371					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TGCAACCACCCTGGGCTCGTC	0.607		NaN											0	0	0	0.01441	0	95	141									
POLE	5426	broad.mit.edu	37	12	133218793	133218793	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:133218793C>T	uc001uks.1	-	38	5187	c.5143G>A	c.(5143-5145)GAG>AAG	p.E1715K	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.E519K|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1715					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CTGTTGATCTCAACAGTGGCT	0.557		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	96	113									
POLE	5426	broad.mit.edu	37	12	133219161	133219161	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:133219161C>G	uc001uks.1	-	37	4927	c.4883G>C	c.(4882-4884)GGA>GCA	p.G1628A	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.G432A|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1628					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GCGCCGGGCTCCATGGCGCTG	0.582		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.01441	0	69	86									
FLT1	2321	broad.mit.edu	37	13	29008208	29008208	+	Silent	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:29008208G>C	uc001usb.3	-	5	948	c.663C>G	c.(661-663)CTC>CTG	p.L221L	FLT1_uc010aar.1_Silent_p.L221L|FLT1_uc001usc.3_Silent_p.L221L|FLT1_uc010tdp.1_Silent_p.L221L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	221	Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTCGATGTGTGAGATAGTTTG	0.353		NaN											0	0	0	0.006122	0	18	66									
FREM2	341640	broad.mit.edu	37	13	39425843	39425843	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:39425843G>A	uc001uwv.2	+	11	7072	c.6763G>A	c.(6763-6765)GAA>AAA	p.E2255K	FREM2_uc001uww.2_Missense_Mutation_p.E341K	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2255	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TAAATTTGGAGAAACCAAATT	0.284		NaN											0	0	0	0.007291	0	30	31									
FREM2	341640	broad.mit.edu	37	13	39425946	39425946	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:39425946G>C	uc001uwv.2	+	11	7175	c.6866G>C	c.(6865-6867)AGA>ACA	p.R2289T	FREM2_uc001uww.2_Missense_Mutation_p.R375T	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2289	Extracellular (Potential).|Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TCCATTGTGAGAGTCCACACC	0.512		NaN											0	0	0	0.005524	0	36	39									
MTRF1	9617	broad.mit.edu	37	13	41791298	41791298	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:41791298C>G	uc001uxx.2	-	12	1761	c.1291G>C	c.(1291-1293)GAA>CAA	p.E431Q	MTRF1_uc001uxy.2_Missense_Mutation_p.E431Q|MTRF1_uc001uxz.2_Missense_Mutation_p.E267Q|MTRF1_uc010tff.1_3'UTR|uc001uxv.1_Intron|uc001uya.1_5'Flank|uc001uyb.2_5'Flank	NM_004294	NP_004285	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	431					regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		GCAATGGCTTCTTCATCTGCT	0.338		NaN											0	0	0	0.015359	0	26	71									
OLFM4	10562	broad.mit.edu	37	13	53624505	53624505	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:53624505G>A	uc001vhl.2	+	5	1132	c.1132G>A	c.(1132-1134)GTT>ATT	p.V378I	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	378	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		ATATGCTAATGTTGCTTGGCA	0.418		NaN											0	0	0	0.01441	0	48	170									
IRS2	8660	broad.mit.edu	37	13	110435067	110435067	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:110435067C>A	uc001vqv.2	-	1	3848	c.3334G>T	c.(3334-3336)GAG>TAG	p.E1112*		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1112					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			GACACCTGCTCCATGAGGCTC	0.751		NaN											1	0	0.00198382	0.001984	0.00200141	5	26									
LRFN5	145581	broad.mit.edu	37	14	42368155	42368155	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:42368155G>A	uc001wvm.2	+	5	3332	c.2134G>A	c.(2134-2136)GAA>AAA	p.E712K	LRFN5_uc010ana.2_3'UTR	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	712	Cytoplasmic (Potential).					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GATTGTCCAGGAAACACAGGT	0.279		NaN								HNSCC(30;0.082)			0	0	0	0.01441	0	46	36									
PTGDR	5729	broad.mit.edu	37	14	52735275	52735275	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:52735275C>T	uc001wzq.2	+	1	845	c.743C>T	c.(742-744)GCG>GTG	p.A248V		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	248	Cytoplasmic (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	GAGCCGCGCGCGGACGGGAGG	0.677		NaN											0	0	0	0.01441	0	75	180									
FERMT2	10979	broad.mit.edu	37	14	53342019	53342019	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:53342019G>C	uc001xad.2	-	8	1075	c.1020C>G	c.(1018-1020)GAC>GAG	p.D340E	FERMT2_uc001xac.2_Missense_Mutation_p.D340E|FERMT2_uc001xae.2_Missense_Mutation_p.D340E|FERMT2_uc001xaf.2_Missense_Mutation_p.D340E	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	340	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					CAACTTCTTTGTCACTGTTGT	0.333		NaN											0	0	0	0.01441	0	50	57									
FERMT2	10979	broad.mit.edu	37	14	53342072	53342072	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:53342072G>C	uc001xad.2	-	8	1022	c.967C>G	c.(967-969)CAT>GAT	p.H323D	FERMT2_uc001xac.2_Missense_Mutation_p.H323D|FERMT2_uc001xae.2_Missense_Mutation_p.H323D|FERMT2_uc001xaf.2_Missense_Mutation_p.H323D	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	323	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					TTATTGATATGATACTGAAAC	0.308		NaN											0	0	0	0.009535	0	32	52									
WDHD1	11169	broad.mit.edu	37	14	55457948	55457948	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:55457948G>C	uc001xbm.1	-	12	1402	c.1324C>G	c.(1324-1326)CTC>GTC	p.L442V	WDHD1_uc010aom.1_Missense_Mutation_p.I20M|WDHD1_uc001xbn.1_Missense_Mutation_p.L319V	NM_007086	NP_009017	O75717	WDHD1_HUMAN	WD repeat and HMG-box DNA binding protein 1	442						cytoplasm|nucleoplasm	DNA binding			skin(1)	1						CTGTGAGTGAGATGCAACGGT	0.388		NaN											0	0	0	0.014323	0	20	24									
COQ6	51004	broad.mit.edu	37	14	74428598	74428598	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:74428598C>G	uc001xph.2	+	11	1449	c.1369C>G	c.(1369-1371)CCA>GCA	p.P457A	ENTPD5_uc001xpi.2_Intron|COQ6_uc001xpe.2_Missense_Mutation_p.P382A|COQ6_uc001xpf.2_Missense_Mutation_p.P382A|COQ6_uc010tuk.1_Missense_Mutation_p.P432A|COQ6_uc001xpg.2_Intron	NM_182476	NP_872282	Q9Y2Z9	COQ6_HUMAN	coenzyme Q6 homolog isoform a	457					ubiquinone biosynthetic process	mitochondrion	flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.00337)		TGCAGTGTCTCCACTCAAAGT	0.373		NaN											0	0	0	0.01441	0	108	107									
LTBP2	4053	broad.mit.edu	37	14	75017934	75017934	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:75017934C>T	uc001xqa.2	-	7	1906	c.1519G>A	c.(1519-1521)GTG>ATG	p.V507M		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	507					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTGGTCTCCACGCTGTTCTCC	0.682		NaN											0	0	0	0.013537	0	13	16									
C14orf4	64207	broad.mit.edu	37	14	77492772	77492772	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:77492772G>A	uc001xsy.2	-	1	2263	c.1364C>T	c.(1363-1365)TCG>TTG	p.S455L		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	455						nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		CTTGAAACCCGAGGATAGGCC	0.612		NaN											0	0	0	0.01441	0	57	61									
PTPN21	11099	broad.mit.edu	37	14	88938710	88938710	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:88938710G>A	uc001xwv.3	-	15	3080	c.2749C>T	c.(2749-2751)CGA>TGA	p.R917*	PTPN21_uc010twc.1_Nonsense_Mutation_p.R713*	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	917	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TCAGGGAGTCGTGCTGTTGAG	0.393		NaN											0	0	0	0.001855	0	12	39									
BTBD7	55727	broad.mit.edu	37	14	93760396	93760396	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr14:93760396A>G	uc001ybo.2	-	3	1296	c.970T>C	c.(970-972)TAT>CAT	p.Y324H	BTBD7_uc010aur.2_5'UTR|BTBD7_uc010two.1_Missense_Mutation_p.Y239H|BTBD7_uc001ybp.2_Intron|BTBD7_uc001ybq.3_Missense_Mutation_p.Y239H|BTBD7_uc001ybr.2_Missense_Mutation_p.Y324H	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	324	BTB 2.									pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACTGTTGCATATTTTTTTGGT	0.418		NaN											0	0	0	0.004007	0	17	44									
OR4N4	283694	broad.mit.edu	37	15	22383192	22383192	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:22383192C>T	uc001yuc.1	+	7	1701	c.720C>T	c.(718-720)TGC>TGT	p.C240C	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Silent_p.C240C	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTCCACGTGCACCACTCGTG	0.493		NaN											0	0	0	0.00632	0	26	189									
IVD	3712	broad.mit.edu	37	15	40703469	40703469	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:40703469G>A	uc001zls.3	+	5	810	c.476G>A	c.(475-477)GGT>GAT	p.G159D	IVD_uc001zlq.2_Missense_Mutation_p.G129D	NM_002225	NP_002216	P26440	IVD_HUMAN	isovaleryl Coenzyme A dehydrogenase isoform 1	156					leucine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|isovaleryl-CoA dehydrogenase activity			ovary(1)	1		all_cancers(109;1.19e-18)|all_epithelial(112;1.52e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0808)		CTGATCAGTGGTGAGTACATC	0.517		NaN											0	0	0	0.01441	0	278	328									
TTBK2	146057	broad.mit.edu	37	15	43044889	43044889	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:43044889G>A	uc001zqo.2	-	14	2994	c.2555C>T	c.(2554-2556)TCA>TTA	p.S852L	TTBK2_uc010bcy.2_Missense_Mutation_p.S783L	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	852					cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		AGAAATTTCTGAAGTTCCAAC	0.373		NaN											0	0	0	0.01441	0	56	64									
MYO5A	4644	broad.mit.edu	37	15	52672022	52672022	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:52672022G>C	uc002aby.2	-	17	2340	c.2096C>G	c.(2095-2097)TCA>TGA	p.S699*	MYO5A_uc002abx.3_Nonsense_Mutation_p.S699*|MYO5A_uc010uge.1_Nonsense_Mutation_p.S568*	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	699	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GGCTCACCGTGAGGGGAAACC	0.448		NaN											0	0	0	0.005443	0	25	122									
LIPC	3990	broad.mit.edu	37	15	58834842	58834842	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:58834842G>A	uc010bga.1	+	6	1174	c.566G>A	c.(565-567)AGA>AAA	p.R189K	LIPC_uc010bfz.1_Missense_Mutation_p.R189K|LIPC_uc002afa.1_Missense_Mutation_p.R189K|LIPC_uc010bgb.1_Missense_Mutation_p.R87K|LIPC_uc010ugy.1_Missense_Mutation_p.R128K	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	189	Heparin-binding (Potential).				cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		AAGATTGGGAGAATCACAGGT	0.498		NaN											0	0	0	0.004289	0	37	111									
ADAMTSL3	57188	broad.mit.edu	37	15	84611709	84611709	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:84611709C>T	uc002bjz.3	+	19	2589	c.2365C>T	c.(2365-2367)CTG>TTG	p.L789L	ADAMTSL3_uc010bmt.1_Silent_p.L789L|ADAMTSL3_uc010bmu.1_Silent_p.L789L	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	789	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGTCGGCAGCTGCTAACGGA	0.547		NaN											0	0	0	0.004482	0	9	43									
AGBL1	123624	broad.mit.edu	37	15	86940646	86940646	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:86940646C>A	uc002blz.1	+	17	2366	c.2286C>A	c.(2284-2286)AGC>AGA	p.S762R		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	762					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						CAGGAGAGAGCAATGCCAGTT	0.453		NaN											1	0	4.93089e-13	0.00245	5.18142e-13	14	39									
NTRK3	4916	broad.mit.edu	37	15	88678348	88678348	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:88678348G>A	uc002bme.1	-	9	1350	c.1188C>T	c.(1186-1188)CTC>CTT	p.L396L	NTRK3_uc002bmh.2_Silent_p.L396L|NTRK3_uc002bmf.1_Silent_p.L396L|NTRK3_uc010upl.1_Silent_p.L298L|NTRK3_uc010bnh.1_Silent_p.L396L|NTRK3_uc002bmg.2_Silent_p.L396L	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	396	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGGGCTCCTTGAGGAAGTGGC	0.527		NaN	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			0	0	0	0.010818	0	30	101									
MEF2A	4205	broad.mit.edu	37	15	100230446	100230446	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr15:100230446G>A	uc010urw.1	+	7	1036	c.677G>A	c.(676-678)GGG>GAG	p.G226E	MEF2A_uc010urv.1_Missense_Mutation_p.G156E|MEF2A_uc010bos.2_Missense_Mutation_p.G224E|MEF2A_uc002bvf.2_Missense_Mutation_p.G226E|MEF2A_uc002bve.2_Missense_Mutation_p.G224E|MEF2A_uc002bvg.2_Missense_Mutation_p.G224E|MEF2A_uc002bvi.2_Missense_Mutation_p.G224E|MEF2A_uc010bot.2_Missense_Mutation_p.G156E	NM_005587	NP_005578	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A isoform 1	226					apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			ovary(1)	1	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			TTCCCCCCAGGGAATGGATTT	0.383		NaN											0	0	0	0.009096	0	4	22									
HCFC1R1	54985	broad.mit.edu	37	16	3073334	3073334	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:3073334C>G	uc002csx.1	-	4	314	c.181G>C	c.(181-183)GAG>CAG	p.E61Q	HCFC1R1_uc002csy.1_Missense_Mutation_p.E61Q|HCFC1R1_uc002csz.1_Missense_Mutation_p.E42Q|THOC6_uc002ctb.2_5'Flank|THOC6_uc002ctd.2_5'Flank|THOC6_uc002ctc.2_5'Flank|THOC6_uc002cta.2_5'Flank	NM_001002018	NP_001002018	Q9NWW0	HPIP_HUMAN	host cell factor C1 regulator 1 (XPO1 dependant)	61						cytoplasm|nucleus					0						ATGTTCTCCTCAGACAGAAAC	0.617		NaN											0	0	0	0.01441	0	94	267									
ZNF75A	7627	broad.mit.edu	37	16	3367835	3367835	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:3367835C>T	uc002cut.3	+	6	1383	c.857C>T	c.(856-858)TCA>TTA	p.S286L	ZNF75A_uc002cuv.3_RNA	NM_153028	NP_694573	Q96N20	ZN75A_HUMAN	zinc finger protein 75a	286	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						AGCAGGCGGTCAAGCCTTCTT	0.453		NaN											0	0	0	0.01441	0	59	42									
ZNF500	26048	broad.mit.edu	37	16	4802759	4802759	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:4802759T>C	uc002cxp.1	-	6	1308	c.1061A>G	c.(1060-1062)AAG>AGG	p.K354R	ZNF500_uc002cxo.1_Missense_Mutation_p.K146R|ZNF500_uc010uxt.1_Missense_Mutation_p.K354R	NM_021646	NP_067678	O60304	ZN500_HUMAN	zinc finger protein 500	354	C2H2-type 2.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						GACTAGGCACTTGTAAGGCCG	0.622		NaN											0	0	0	0.01441	0	111	117									
ITPRIPL2	162073	broad.mit.edu	37	16	19125972	19125972	+	Silent	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:19125972C>A	uc002dfu.3	+	1	719	c.189C>A	c.(187-189)CTC>CTA	p.L63L	ITPRIPL2_uc002dft.2_5'UTR	NM_001034841	NP_001030013	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-triphosphate receptor interacting	63	Helical; (Potential).					integral to membrane				skin(2)	2						GCTATGTCCTCCTGCGCTGTC	0.721		NaN											1	0	0.00448238	0.004482	0.00451213	8	55									
RABEP2	79874	broad.mit.edu	37	16	28925598	28925598	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:28925598G>A	uc002drq.2	-	5	901	c.853C>T	c.(853-855)CAG>TAG	p.Q285*	uc010vct.1_Intron|RABEP2_uc010vdf.1_Nonsense_Mutation_p.Q214*|RABEP2_uc010byn.2_Nonsense_Mutation_p.Q285*|RABEP2_uc002drr.2_Nonsense_Mutation_p.Q285*	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	285					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						GGGACGAGCTGGTAGCCAGGA	0.652		NaN											0	0	0	0.004656	0	26	82									
HIRIP3	8479	broad.mit.edu	37	16	30004529	30004529	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:30004529C>T	uc002dve.2	-	7	2131	c.1670G>A	c.(1669-1671)TGA>TAA	p.*557*	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|HIRIP3_uc002dvf.2_3'UTR	NM_003609	NP_003600	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	557					chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)	1						TGGCAGAGCTCAGTTACTCTC	0.567		NaN											0	0	0	0.01441	0	69	58									
MT1H	4496	broad.mit.edu	37	16	56703818	56703818	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:56703818G>A	uc002ejw.2	+	1	93	c.22G>A	c.(22-24)GAG>AAG	p.E8K	MT1G_uc002eju.1_5'Flank|MT1G_uc002ejv.1_5'Flank	NM_005951	NP_005942	P80294	MT1H_HUMAN	metallothionein 1H	8	Beta.						metal ion binding|protein binding				0						CTGCTCCTGCGAGGCTGGTAA	0.567		NaN											0	0	0	0.01441	0	69	277									
NDRG4	65009	broad.mit.edu	37	16	58538305	58538305	+	Silent	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:58538305C>G	uc002eno.2	+	4	397	c.291C>G	c.(289-291)CCC>CCG	p.P97P	NDRG4_uc002enk.2_Silent_p.P129P|NDRG4_uc002enm.2_Silent_p.P149P|NDRG4_uc010vif.1_Silent_p.P129P|NDRG4_uc010cdk.2_Silent_p.P115P|NDRG4_uc010vig.1_Silent_p.P127P|NDRG4_uc010vih.1_Silent_p.P42P|NDRG4_uc010vii.1_Silent_p.P115P|NDRG4_uc002enp.2_Silent_p.P97P|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	97					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						CCATGCTCCCCAGCGTGGTGC	0.677		NaN											0	0	0	0.01441	0	216	214									
FAM65A	79567	broad.mit.edu	37	16	67574554	67574554	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:67574554G>C	uc010vjp.1	+	10	904	c.808G>C	c.(808-810)GAC>CAC	p.D270H	FAM65A_uc010cei.1_Missense_Mutation_p.D92H|FAM65A_uc002eth.2_Missense_Mutation_p.D250H|FAM65A_uc010cej.2_Missense_Mutation_p.D253H|FAM65A_uc002eti.1_Missense_Mutation_p.D213H|FAM65A_uc010vjq.1_Missense_Mutation_p.D264H|FAM65A_uc002etj.1_Missense_Mutation_p.D249H|FAM65A_uc002etk.2_Missense_Mutation_p.D249H	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	254						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GCAGGTGTGGGACAGTGAAGA	0.547		NaN											0	0	0	0.01441	0	193	174									
ESRP2	80004	broad.mit.edu	37	16	68266170	68266170	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:68266170C>G	uc010cfa.1	-	9	1194	c.1006G>C	c.(1006-1008)GAG>CAG	p.E336Q	ESRP2_uc002evp.1_RNA|ESRP2_uc002evq.1_Missense_Mutation_p.E326Q	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	336	RRM 1.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						TTTACAAACTCCTCCCCTGTC	0.582		NaN											0	0	0	0.01441	0	56	70									
SLC7A6OS	84138	broad.mit.edu	37	16	68335260	68335260	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:68335260C>G	uc002evw.1	-	5	867	c.848G>C	c.(847-849)AGA>ACA	p.R283T	SLC7A6_uc002evt.1_3'UTR|SLC7A6_uc002evu.1_3'UTR|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_032178	NP_115554	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite	283					protein transport	cytoplasm|nucleus				ovary(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		CATCCGCTGTCTGCTGCTGCC	0.522		NaN											0	0	0	0.01441	0	73	79									
PKD1L2	114780	broad.mit.edu	37	16	81241228	81241228	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:81241228A>T	uc002fgh.1	-	5	773	c.773T>A	c.(772-774)ATG>AAG	p.M258K	PKD1L2_uc002fgj.2_Missense_Mutation_p.M258K	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	258	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACTGGACACCATCAGCTGCAG	0.443		NaN											0	0	0	0.01441	0	65	85									
TSR1	55720	broad.mit.edu	37	17	2237950	2237950	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:2237950T>C	uc002fuj.2	-	5	1754	c.797A>G	c.(796-798)AAT>AGT	p.N266S	SGSM2_uc002fum.3_5'Flank|SGSM2_uc010vqw.1_5'Flank|SGSM2_uc002fun.3_5'Flank	NM_018128	NP_060598	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation	266					ribosome assembly	nucleolus	protein binding			ovary(1)	1						CACCAAGTTATTCTCTTCACT	0.458		NaN											0	0	0	0.01441	0	104	311									
ZNF624	57547	broad.mit.edu	37	17	16526354	16526354	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526354C>T	uc010cpi.1	-	6	1929	c.1846G>A	c.(1846-1848)GAC>AAC	p.D616N		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	616	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CTCTCGCAGTCAGTACATTTA	0.383		NaN											0	0	0	0.01441	0	161	197									
ZNF624	57547	broad.mit.edu	37	17	16526391	16526391	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526391C>G	uc010cpi.1	-	6	1892	c.1809G>C	c.(1807-1809)CAG>CAC	p.Q603H		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	603	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGTGAATTCTCTGATGTACAG	0.378		NaN											0	0	0	0.01441	0	149	164									
ZNF624	57547	broad.mit.edu	37	17	16526600	16526600	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526600C>T	uc010cpi.1	-	6	1683	c.1600G>A	c.(1600-1602)GGG>AGG	p.G534R		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	534	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AATGCTTTCCCACATTCATTA	0.383		NaN											0	0	0	0.01441	0	92	87									
ZNF624	57547	broad.mit.edu	37	17	16526725	16526725	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526725C>T	uc010cpi.1	-	6	1558	c.1475G>A	c.(1474-1476)AGA>AAA	p.R492K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	492	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AGTGTGAGTTCTTATATGTAC	0.383		NaN											0	0	0	0.01441	0	81	92									
ZNF624	57547	broad.mit.edu	37	17	16526782	16526782	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526782C>G	uc010cpi.1	-	6	1501	c.1418G>C	c.(1417-1419)AGA>ACA	p.R473T		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	473	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTCGTTACATCTAAAAGGTTT	0.373		NaN											0	0	0	0.01441	0	68	69									
ZNF624	57547	broad.mit.edu	37	17	16526838	16526838	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526838C>G	uc010cpi.1	-	6	1445	c.1362G>C	c.(1360-1362)AAG>AAC	p.K454N		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	454	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTGTGGTATTCTTAAAAGACT	0.383		NaN											0	0	0	0.01441	0	56	67									
ZNF624	57547	broad.mit.edu	37	17	16526858	16526858	+	Missense_Mutation	SNP	C	C	T	rs138787716		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526858C>T	uc010cpi.1	-	6	1425	c.1342G>A	c.(1342-1344)GAG>AAG	p.E448K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	448	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TTCCCACACTCGTTGCACTGA	0.388		NaN											0	0	0	0.01441	0	55	71									
ZNF624	57547	broad.mit.edu	37	17	16526922	16526922	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526922C>T	uc010cpi.1	-	6	1361	c.1278G>A	c.(1276-1278)AGG>AGA	p.R426R		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	426	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		ATGACTTGTTCCTAAAGGCTT	0.388		NaN											0	0	0	0.01441	0	61	66									
ZNF624	57547	broad.mit.edu	37	17	16526945	16526945	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526945C>G	uc010cpi.1	-	6	1338	c.1255G>C	c.(1255-1257)GAT>CAT	p.D419H		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	419	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCACAATCATCACATTTGTAG	0.403		NaN											0	0	0	0.01441	0	59	69									
ZNF624	57547	broad.mit.edu	37	17	16526963	16526963	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16526963C>T	uc010cpi.1	-	6	1320	c.1237G>A	c.(1237-1239)GAG>AAG	p.E413K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TAGGGTTTCTCACCATTGTGA	0.388		NaN											0	0	0	0.01441	0	58	71									
ZNF624	57547	broad.mit.edu	37	17	16527313	16527313	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527313C>G	uc010cpi.1	-	6	970	c.887G>C	c.(886-888)AGA>ACA	p.R296T		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	296	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AGTATGAGTTCTTTGATGTTG	0.348		NaN											0	0	0	0.01441	0	90	65									
ZNF624	57547	broad.mit.edu	37	17	16527465	16527465	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527465C>G	uc010cpi.1	-	6	818	c.735G>C	c.(733-735)AAG>AAC	p.K245N		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGCAAATTATCTTCCCCAAAT	0.383		NaN											0	0	0	0.01441	0	100	101									
ZNF624	57547	broad.mit.edu	37	17	16527501	16527501	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527501C>G	uc010cpi.1	-	6	782	c.699G>C	c.(697-699)GAG>GAC	p.E233D		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		AATTTAAATTCTCTGTGAAAT	0.393		NaN											0	0	0	0.01441	0	82	91									
ZNF624	57547	broad.mit.edu	37	17	16527670	16527670	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527670C>G	uc010cpi.1	-	6	613	c.530G>C	c.(529-531)AGA>ACA	p.R177T		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		ATTTTGTAATCTCAATATCCT	0.358		NaN											0	0	0	0.01441	0	83	72									
ZNF624	57547	broad.mit.edu	37	17	16527693	16527693	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527693C>T	uc010cpi.1	-	6	590	c.507G>A	c.(505-507)TGG>TGA	p.W169*		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CATTCCATTTCCATAACCCTT	0.383		NaN											0	0	0	0.01441	0	90	85									
ZNF624	57547	broad.mit.edu	37	17	16527709	16527709	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527709C>T	uc010cpi.1	-	6	574	c.491G>A	c.(490-492)AGA>AAA	p.R164K		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCCTTCCATTCTGGAATCCCA	0.393		NaN											0	0	0	0.01441	0	85	97									
ZNF624	57547	broad.mit.edu	37	17	16527767	16527767	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:16527767C>T	uc010cpi.1	-	6	516	c.433G>A	c.(433-435)GAT>AAT	p.D145N		NM_020787	NP_065838	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TGTGATAAATCTTCAGAAATA	0.408		NaN											0	0	0	0.01441	0	85	88									
MYO15A	51168	broad.mit.edu	37	17	18022918	18022918	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:18022918C>A	uc010vxh.1	+	2	1142	c.804C>A	c.(802-804)AGC>AGA	p.S268R		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	268	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GCCCCTACAGCCCGGCCTGGC	0.642		NaN											1	0	1.59438e-142	0.01441	1.74806e-142	272	39									
ERBB2	2064	broad.mit.edu	37	17	37880261	37880261	+	Missense_Mutation	SNP	G	G	A	rs121913468		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:37880261G>A	uc002hso.2	+	19	2543	c.2305G>A	c.(2305-2307)GAC>AAC	p.D769N	ERBB2_uc002hsm.2_Missense_Mutation_p.D739N|ERBB2_uc010cwa.2_Missense_Mutation_p.D754N|ERBB2_uc002hsp.2_Missense_Mutation_p.D572N|ERBB2_uc010cwb.2_Missense_Mutation_p.D769N|ERBB2_uc010wek.1_Missense_Mutation_p.D493N	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	769	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.D769H(3)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	AGAAATCTTAGACGTAAGCCC	0.532		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.01441	0	256	18									
KRTAP4-9	100132386	broad.mit.edu	37	17	39261731	39261731	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:39261731G>A	uc010wfp.1	+	1	91	c.91G>A	c.(91-93)GAG>AAG	p.E31K		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	31	2.|29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament					0						CAGCTGCTGTGAGACCACCTG	0.637		NaN											0	0	0	0.01441	0	52	19									
KAT2A	2648	broad.mit.edu	37	17	40265828	40265828	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:40265828G>A	uc002hyx.2	-	18	2413	c.2353C>T	c.(2353-2355)CGC>TGC	p.R785C	DHX58_uc002hyv.3_5'Flank|DHX58_uc002hyw.3_5'Flank|DHX58_uc010wgf.1_5'Flank	NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	785	Bromo.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						ACGTAGTAGCGGCTTCGCAGC	0.632		NaN											0	0	0	0.008871	0	20	56									
TLK2	11011	broad.mit.edu	37	17	60655841	60655841	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:60655841G>A	uc010ddp.2	+	15	1526	c.1258G>A	c.(1258-1260)GAA>AAA	p.E420K	TLK2_uc002izx.3_Missense_Mutation_p.E246K|TLK2_uc002izz.3_Missense_Mutation_p.E398K|TLK2_uc002jaa.3_Missense_Mutation_p.E366K|TLK2_uc010wpd.1_Missense_Mutation_p.E366K	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	420	Potential.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						GCTTTAGGAGGAAGCAGAGAT	0.368		NaN											0	0	0	0.008291	0	11	78									
CCDC46	201134	broad.mit.edu	37	17	64049896	64049896	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:64049896C>T	uc002jfl.2	-	12	1395	c.1176G>A	c.(1174-1176)CTG>CTA	p.L392L	CCDC46_uc010deo.2_Silent_p.L134L|CCDC46_uc002jfm.2_Silent_p.L392L|CCDC46_uc010dep.2_Silent_p.L350L	NM_145036	NP_659473	Q8N8E3	CE112_HUMAN	coiled-coil domain containing 46 isoform a	392	Potential.					centrosome					0			BRCA - Breast invasive adenocarcinoma(6;1.53e-06)			CCATTTTATTCAGACGCACAT	0.388		NaN											0	0	0	0.009718	0	41	206									
NAT9	26151	broad.mit.edu	37	17	72767986	72767986	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:72767986G>A	uc002jlq.2	-	7	575	c.501C>T	c.(499-501)AGC>AGT	p.S167S	NAT9_uc002jlr.2_Silent_p.S166S	NM_015654	NP_056469	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9	167	N-acetyltransferase.					protein complex	N-acetyltransferase activity				0						GAAAAACACTGCTCGTAGCCA	0.557		NaN											0	0	0	0.01441	0	89	137									
FADS6	283985	broad.mit.edu	37	17	72888659	72888659	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:72888659G>A	uc002jmd.1	-	2	360	c.348C>T	c.(346-348)TTC>TTT	p.F116F		NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	122	Helical; (Potential).				fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					CCTCCACAAAGAAAAGCAGCC	0.597		NaN											0	0	0	0.00874	0	39	52									
TNRC6C	57690	broad.mit.edu	37	17	76047083	76047083	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:76047083C>T	uc002jud.2	+	4	2540	c.1940C>T	c.(1939-1941)ACA>ATA	p.T647I	TNRC6C_uc002juf.2_Missense_Mutation_p.T647I|TNRC6C_uc002jue.2_Missense_Mutation_p.T647I	NM_018996	NP_061869	Q9HCJ0	TNR6C_HUMAN	trinucleotide repeat containing 6C isoform 2	647	Sufficient for interaction with argonaute family proteins.				gene silencing by RNA|regulation of translation		nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			AGCACAAATACAAAGGCCAAT	0.502		NaN											0	0	0	0.00632	0	29	36									
TBC1D16	125058	broad.mit.edu	37	17	77922741	77922741	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:77922741C>T	uc002jxj.2	-	8	1587	c.1471G>A	c.(1471-1473)GAC>AAC	p.D491N	TBC1D16_uc002jxh.2_Missense_Mutation_p.D129N|TBC1D16_uc002jxi.2_Missense_Mutation_p.D116N|TBC1D16_uc002jxk.1_Missense_Mutation_p.D129N	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	491	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			CGGACCACGTCTTTGTCCACA	0.602		NaN											0	0	0	0.01441	0	208	331									
CCDC40	55036	broad.mit.edu	37	17	78058702	78058702	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:78058702C>G	uc010dht.2	+	13	2177	c.2150C>G	c.(2149-2151)TCC>TGC	p.S717C	CCDC40_uc002jxm.3_Missense_Mutation_p.S500C|CCDC40_uc002jxn.3_Missense_Mutation_p.S113C	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	717	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGCGAGATCTCCCGGCGCACG	0.602		NaN											0	0	0	0.01441	0	63	106									
CCDC40	55036	broad.mit.edu	37	17	78059829	78059829	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:78059829G>C	uc010dht.2	+	14	2290	c.2263G>C	c.(2263-2265)GAA>CAA	p.E755Q	CCDC40_uc002jxm.3_Missense_Mutation_p.E538Q|CCDC40_uc002jxn.3_Missense_Mutation_p.E151Q	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	755	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CCTGGAGCTTGAAATCAAAAG	0.448		NaN											0	0	0	0.01441	0	123	197									
EMILIN2	84034	broad.mit.edu	37	18	2892205	2892205	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:2892205G>A	uc002kln.2	+	4	2239	c.2080G>A	c.(2080-2082)GGG>AGG	p.G694R		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	694					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		ATGCACGCAGGGGGTCCAGAG	0.562		NaN											0	0	0	0.01441	0	112	141									
ROCK1	6093	broad.mit.edu	37	18	18622100	18622100	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:18622100G>C	uc002kte.2	-	8	1858	c.917C>G	c.(916-918)TCA>TGA	p.S306*		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	306	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					TGCTTCTTTTGATATGTCATT	0.333		NaN											0	0	0	0.016522	0	22	59									
OSBPL1A	114876	broad.mit.edu	37	18	21746618	21746618	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:21746618C>G	uc002kve.2	-	26	2758	c.2584G>C	c.(2584-2586)GAC>CAC	p.D862H	OSBPL1A_uc002kvd.2_Missense_Mutation_p.D349H|OSBPL1A_uc010xbc.1_Missense_Mutation_p.D480H	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	862					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					CTCTCCATGTCTTTGTCTACT	0.398		NaN											0	0	0	0.01441	0	74	62									
ST8SIA3	51046	broad.mit.edu	37	18	55024415	55024415	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:55024415G>A	uc002lgn.2	+	3	931	c.574G>A	c.(574-576)GCC>ACC	p.A192T		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	192	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		TTGCAATTTCGCCCCTACGGA	0.403		NaN											0	0	0	0.01441	0	71	56									
C18orf22	79863	broad.mit.edu	37	18	77794621	77794621	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr18:77794621G>C	uc002lns.2	+	1	264	c.126G>C	c.(124-126)AAG>AAC	p.K42N	TXNL4A_uc010drg.2_5'Flank|C18orf22_uc010drh.2_Missense_Mutation_p.K42N|C18orf22_uc010dri.1_RNA	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	42					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		TCTCCTGCAAGAACTGGCTCA	0.657		NaN											0	0	0	0.013537	0	13	198									
DOT1L	84444	broad.mit.edu	37	19	2222099	2222099	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:2222099C>T	uc002lvb.3	+	24	2967	c.2931C>T	c.(2929-2931)ACC>ACT	p.T977T	DOT1L_uc002lvc.1_Silent_p.T271T|DOT1L_uc002lve.1_3'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	977						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTTTGCCACCGTGGGGTCCC	0.701		NaN											0	0	0	0.01441	0	97	113									
PLIN3	10226	broad.mit.edu	37	19	4859618	4859618	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:4859618T>C	uc002mbj.2	-	4	509	c.332A>G	c.(331-333)CAG>CGG	p.Q111R	PLIN3_uc002mbk.2_Missense_Mutation_p.Q111R|PLIN3_uc002mbl.3_Missense_Mutation_p.Q111R	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	111				ILQ -> MLR (in Ref. 2; AAD11622).	vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	CGTGGGCTGCTGCAGGATGGG	0.572		NaN											0	0	0	0.01441	0	76	74									
C3	718	broad.mit.edu	37	19	6686860	6686860	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:6686860C>T	uc002mfm.2	-	28	3605	c.3543G>A	c.(3541-3543)ATG>ATA	p.M1181I	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1181					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TCTGTAGGTTCATGTAGTTGG	0.517		NaN											0	0	0	0.01441	0	114	107									
DNASE2	1777	broad.mit.edu	37	19	12991823	12991823	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:12991823C>T	uc002mvn.1	-	2	376	c.230G>A	c.(229-231)CGA>CAA	p.R77Q	DNASE2_uc010xmr.1_Missense_Mutation_p.R77Q	NM_001375	NP_001366	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal precursor	77					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding				0						CTGCAGGCTTCGGCCCACGGC	0.677		NaN						Direct_reversal_of_damage					0	0	0	0.01441	0	72	73									
CPAMD8	27151	broad.mit.edu	37	19	17039045	17039045	+	Splice_Site	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:17039045C>G	uc002nfb.2	-	25	3318	c.3286_splice	c.e25-1	p.V1096_splice		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain							extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CATGGCCAACCTGGAAAAAGA	0.597		NaN											0	0	0	0.00245	0	15	61									
HAUS8	93323	broad.mit.edu	37	19	17166705	17166705	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:17166705G>A	uc002nfe.2	-	9	864	c.753C>T	c.(751-753)TCC>TCT	p.S251S	HAUS8_uc002nff.2_Silent_p.S250S|HAUS8_uc002nfg.1_Silent_p.S190S|HAUS8_uc002nfh.1_Silent_p.S251S	NM_033417	NP_219485	Q9BT25	HAUS8_HUMAN	sarcoma antigen NY-SAR-48 isoform a	251					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole					0						CCAGGTGGATGGACCTCACGG	0.642		NaN											0	0	0	0.008361	0	28	88									
B3GNT3	10331	broad.mit.edu	37	19	17922410	17922410	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:17922410T>G	uc002nhk.1	+	3	683	c.598T>G	c.(598-600)TGC>GGC	p.C200G	B3GNT3_uc002nhl.1_Missense_Mutation_p.C200G|B3GNT3_uc010ebd.1_Missense_Mutation_p.C200G|B3GNT3_uc010ebe.1_Missense_Mutation_p.C200G	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	200	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						GGAGACAAGGTGCGCCAACGC	0.572		NaN											0	0	0	0.00632	0	15	122									
JAK3	3718	broad.mit.edu	37	19	17953857	17953857	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:17953857C>T	uc002nhn.3	-	5	645	c.545G>A	c.(544-546)GGA>GAA	p.G182E	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.G182E|JAK3_uc010xpx.1_Missense_Mutation_p.G182E|JAK3_uc010xpy.1_3'UTR	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	182	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CAGCAGCTCTCCCGGCCGCTG	0.687		2	Mis		acute megakaryocytic leukemia|								0	0	0	0.01441	0	49	79									
ISYNA1	51477	broad.mit.edu	37	19	18546114	18546114	+	Silent	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:18546114C>A	uc002njd.1	-	10	1484	c.1434G>T	c.(1432-1434)GCG>GCT	p.A478A	ISYNA1_uc002nja.1_Silent_p.A350A|ISYNA1_uc002njb.1_Silent_p.A396A|ISYNA1_uc002njc.1_Silent_p.A328A|ISYNA1_uc010xqh.1_Silent_p.A276A|ISYNA1_uc002nje.1_Silent_p.A424A|ISYNA1_uc002njf.1_Silent_p.A328A	NM_016368	NP_057452	Q9NPH2	INO1_HUMAN	inositol-3-phosphate synthase 1	478					inositol biosynthetic process|phospholipid biosynthetic process	cytoplasm	binding|inositol-3-phosphate synthase activity			ovary(1)|pancreas(1)	2						GGCGGAAAAGCGCATTGACCA	0.662		NaN											1	0	7.01153e-11	0.007291	7.31708e-11	27	387									
ZNF90	7643	broad.mit.edu	37	19	20229706	20229706	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:20229706G>A	uc002nor.2	+	4	1482	c.1343G>A	c.(1342-1344)AGT>AAT	p.S448N	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	448						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ATAATTCATAGTGGAGAGAAA	0.393		NaN											0	0	0	0.014758	0	5	34									
ZNF99	7652	broad.mit.edu	37	19	22940978	22940978	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:22940978G>A	uc010xrh.1	-	5	1460	c.1460C>T	c.(1459-1461)TCA>TTA	p.S487L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGTAAGATGTGAAGATTGCTT	0.358		NaN											0	0	0	0.00245	0	15	74									
ZNF99	7652	broad.mit.edu	37	19	22941120	22941120	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:22941120G>A	uc010xrh.1	-	5	1318	c.1318C>T	c.(1318-1320)CAT>TAT	p.H440Y		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTCCAGTATGAATTATCTTA	0.343		NaN											0	0	0	0.007835	0	38	44									
CATSPERG	57828	broad.mit.edu	37	19	38860868	38860868	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:38860868C>T	uc002oih.3	+	28	3270	c.3183C>T	c.(3181-3183)CTC>CTT	p.L1061L	CATSPERG_uc002oig.3_Silent_p.L1021L|CATSPERG_uc002oif.3_Silent_p.L701L|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1061	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						GGCTGCCACTCAGTCCCAAGC	0.602		NaN											0	0	0	0.013726	0	33	89									
PSG1	5669	broad.mit.edu	37	19	43376148	43376148	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:43376148C>T	uc002ovb.2	-	3	618	c.480G>A	c.(478-480)GAG>GAA	p.E160E	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Silent_p.E160E|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Silent_p.E160E|PSG1_uc010eio.1_Silent_p.E160E|PSG1_uc002oux.1_Silent_p.E89E|PSG1_uc002ouy.1_Silent_p.E160E|PSG1_uc002ouz.1_Silent_p.E160E|PSG1_uc002ova.1_Intron|PSG1_uc002ovc.2_Intron|PSG1_uc002ovd.1_Silent_p.E160E	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	160	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				CCTCCATGGTCTCCCTGGGAT	0.537		NaN											0	0	0	0.01441	0	61	270									
MARK4	57787	broad.mit.edu	37	19	45774817	45774817	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:45774817G>C	uc002pbb.1	+	8	642	c.637G>C	c.(637-639)GAC>CAC	p.D213H	MARK4_uc002paz.1_Missense_Mutation_p.W23C|MARK4_uc002pba.1_Missense_Mutation_p.D213H|MARK4_uc002pbc.1_Missense_Mutation_p.D79H			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	213	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ATCGAAGCTGGACACGTTCTG	0.597		NaN											0	0	0	0.01441	0	68	245									
SYMPK	8189	broad.mit.edu	37	19	46338423	46338423	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:46338423G>C	uc002pdn.2	-	11	1551	c.1306C>G	c.(1306-1308)CCC>GCC	p.P436A	SYMPK_uc002pdo.1_Missense_Mutation_p.P436A|SYMPK_uc002pdp.1_Missense_Mutation_p.P436A|SYMPK_uc002pdq.1_Missense_Mutation_p.P436A	NM_004819	NP_004810	Q92797	SYMPK_HUMAN	symplekin	436					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			ovary(1)	1		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		GACTCCACGGGGGTGTAGATG	0.602		NaN											0	0	0	0.01441	0	99	62									
MYPOP	339344	broad.mit.edu	37	19	46393930	46393930	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:46393930C>G	uc002pdt.2	-	3	1238	c.1151G>C	c.(1150-1152)AGA>ACA	p.R384T		NM_001012643	NP_001012661	Q86VE0	MYPOP_HUMAN	Myb protein P42POP	384	Nuclear localization signal (By similarity).					nucleus	DNA binding				0						GAAACCTTTTCTCCGCTTGTG	0.642		NaN											0	0	0	0.011902	0	43	124									
PGLYRP1	8993	broad.mit.edu	37	19	46522875	46522875	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:46522875G>A	uc002pdx.1	-	2	362	c.318C>T	c.(316-318)TAC>TAT	p.Y106Y		NM_005091	NP_005082	O75594	PGRP1_HUMAN	peptidoglycan recognition protein 1 precursor	106					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region	bacterial cell surface binding|N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)	2		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		CACGGCCCTCGTATACGAGCC	0.587		NaN											0	0	0	0.00632	0	24	138									
PRKD2	25865	broad.mit.edu	37	19	47178369	47178369	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:47178369T>C	uc002pfh.2	-	18	2687	c.2345A>G	c.(2344-2346)GAC>GGC	p.D782G	PRKD2_uc002pfd.2_Missense_Mutation_p.D156G|PRKD2_uc010eks.2_Missense_Mutation_p.D185G|PRKD2_uc010ekt.2_Missense_Mutation_p.D49G|PRKD2_uc002pfe.2_Missense_Mutation_p.D312G|PRKD2_uc002pff.2_Missense_Mutation_p.D302G|PRKD2_uc002pfg.2_Missense_Mutation_p.D625G|PRKD2_uc002pfi.2_Missense_Mutation_p.D782G|PRKD2_uc002pfj.2_Missense_Mutation_p.D782G|PRKD2_uc010xye.1_Missense_Mutation_p.D792G|PRKD2_uc002pfk.2_Missense_Mutation_p.D625G	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	782	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		GTTGATGAGGTCAATGGCTGC	0.567		NaN											0	0	0	0.010818	0	31	20									
NLRP9	338321	broad.mit.edu	37	19	56244156	56244156	+	Silent	SNP	C	C	T	rs146611098		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:56244156C>T	uc002qly.2	-	2	1069	c.1041G>A	c.(1039-1041)GTG>GTA	p.V347V		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	347	NACHT.					cytoplasm	ATP binding	p.V347V(1)		skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GCCTCTGTTTCACACAAGTAC	0.418		NaN											0	0	0	0.01441	0	209	35									
NLRP9	338321	broad.mit.edu	37	19	56244288	56244288	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:56244288C>G	uc002qly.2	-	2	937	c.909G>C	c.(907-909)AAG>AAC	p.K303N		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	303	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AATACGACTTCTTTTCAGATT	0.388		NaN											0	0	0	0.01441	0	112	25									
ZNF274	10782	broad.mit.edu	37	19	58724434	58724434	+	Silent	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:58724434C>A	uc002qrq.1	+	10	2346	c.1887C>A	c.(1885-1887)ACC>ACA	p.T629T	ZNF274_uc002qrr.1_Silent_p.T597T|ZNF274_uc002qrs.1_Silent_p.T524T|ZNF274_uc010eum.1_Silent_p.T388T	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	629	C2H2-type 5.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		AGGCCTTCACCCAGAGCTCAC	0.517		NaN											1	0	2.40228e-13	0.013114	2.53018e-13	46	409									
MYT1L	23040	broad.mit.edu	37	2	1926269	1926269	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:1926269G>T	uc002qxe.2	-	10	2099	c.1272C>A	c.(1270-1272)TTC>TTA	p.F424L	MYT1L_uc002qxd.2_Missense_Mutation_p.F424L|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	424					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TGGTCATGTCGAACACCTCTT	0.567		NaN											1	0	1.85244e-09	0.00333	1.92434e-09	24	121									
APOB	338	broad.mit.edu	37	2	21230048	21230048	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:21230048T>C	uc002red.2	-	26	9820	c.9692A>G	c.(9691-9693)GAT>GGT	p.D3231G		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3231	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTGTACTTATCAAACTTAAT	0.368		NaN											0	0	0	0.004482	0	9	39									
LTBP1	4052	broad.mit.edu	37	2	33568000	33568000	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:33568000C>G	uc002ros.2	+	25	3829	c.3829C>G	c.(3829-3831)CAA>GAA	p.Q1277E	LTBP1_uc002rot.2_Missense_Mutation_p.Q951E|LTBP1_uc002rou.2_Missense_Mutation_p.Q950E|LTBP1_uc002rov.2_Missense_Mutation_p.Q897E|LTBP1_uc010ymz.1_Intron|LTBP1_uc010yna.1_Intron|LTBP1_uc010ynb.1_Intron	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1276	EGF-like 13; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCAGGGCTTTCAAGCCCCACA	0.458		NaN											0	0	0	0.00499	0	18	59									
MTIF2	4528	broad.mit.edu	37	2	55476578	55476578	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:55476578C>T	uc002ryn.2	-	10	1671	c.934G>A	c.(934-936)GAA>AAA	p.E312K	MTIF2_uc010yox.1_5'UTR|MTIF2_uc002ryo.2_Missense_Mutation_p.E312K	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	312	G-domain.				regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						CCATAATCTTCACATACCACA	0.433		NaN											0	0	0	0.008871	0	20	79									
SMEK2	57223	broad.mit.edu	37	2	55825620	55825620	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:55825620C>G	uc002rzc.2	-	4	1228	c.853G>C	c.(853-855)GAG>CAG	p.E285Q	SMEK2_uc002rzb.2_Missense_Mutation_p.E285Q|SMEK2_uc002rzd.2_Missense_Mutation_p.E285Q|SMEK2_uc002rza.2_Missense_Mutation_p.E161Q	NM_001122964	NP_001116436	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 isoform 1	285						microtubule organizing center|nucleus	protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AGAAAATTCTCTTCAAAAACA	0.348		NaN											0	0	0	0.01441	0	61	37									
GPAT2	150763	broad.mit.edu	37	2	96688908	96688908	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:96688908T>G	uc002svf.2	-	19	2318	c.2095A>C	c.(2095-2097)AAG>CAG	p.K699Q	GPAT2_uc002svd.2_Missense_Mutation_p.K518Q|GPAT2_uc002sve.2_Missense_Mutation_p.K501Q|GPAT2_uc002svg.2_Missense_Mutation_p.K578Q|GPAT2_uc010yuh.1_Missense_Mutation_p.K628Q|GPAT2_uc002svh.2_Intron	NM_207328	NP_997211	Q6NUI2	GPAT2_HUMAN	glycerol-3-phosphate acyltransferase 2,	699					glycerol-3-phosphate metabolic process|phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity				0						GCAAAGGCCTTGAGCAGCGGG	0.642		NaN											0	0	0	0.001855	0	12	53									
SLC9A4	389015	broad.mit.edu	37	2	103090411	103090411	+	Missense_Mutation	SNP	G	G	A	rs141209381		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:103090411G>A	uc002tbz.3	+	1	650	c.193G>A	c.(193-195)GAC>AAC	p.D65N		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	65	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						ACTGGATTATGACTATGTGCA	0.423		NaN											0	0	0	0.005443	0	28	216									
SULT1C2	6819	broad.mit.edu	37	2	108910720	108910720	+	Missense_Mutation	SNP	G	G	C	rs144954759		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:108910720G>C	uc002tdy.2	+	3	640	c.187G>C	c.(187-189)GAA>CAA	p.E63Q	SULT1C2_uc010ywp.1_5'UTR|SULT1C2_uc002tdx.2_Missense_Mutation_p.E63Q|SULT1C2_uc010ywq.1_Missense_Mutation_p.E63Q	NM_001056	NP_001047	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 1	63					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			ovary(1)	1						GGATATGATTGAACAGAATGG	0.517		NaN											0	0	0	0.01441	0	127	76									
GCC2	9648	broad.mit.edu	37	2	109088444	109088444	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:109088444C>G	uc002tec.2	+	6	2813	c.2659C>G	c.(2659-2661)CAA>GAA	p.Q887E	GCC2_uc002ted.2_Missense_Mutation_p.Q786E	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	887	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AGAAGTATCTCAAACATGTAG	0.308		NaN											0	0	0	0.01441	0	52	38									
SCTR	6344	broad.mit.edu	37	2	120204401	120204401	+	Silent	SNP	G	G	A	rs140245245		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:120204401G>A	uc002tma.2	-	11	1300	c.1074C>T	c.(1072-1074)TTC>TTT	p.F358F	SCTR_uc002tlz.2_Silent_p.F180F	NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	358	Helical; Name=6; (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	GGGAGAAGGCGAAGACGATGT	0.572		NaN											0	0	0	0.004878	0	30	139									
CLASP1	23332	broad.mit.edu	37	2	122098465	122098465	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:122098465G>A	uc002tnc.2	-	39	4979	c.4589C>T	c.(4588-4590)TCC>TTC	p.S1530F	CLASP1_uc010yyv.1_Missense_Mutation_p.S576F|CLASP1_uc002tmz.2_Missense_Mutation_p.S615F|CLASP1_uc002tna.2_Missense_Mutation_p.S576F|CLASP1_uc010yyw.1_RNA|CLASP1_uc002tnb.2_RNA|CLASP1_uc010yyx.1_RNA|CLASP1_uc010yyy.1_RNA|CLASP1_uc010yyz.1_Missense_Mutation_p.S1471F|CLASP1_uc010yza.1_Missense_Mutation_p.S1463F|CLASP1_uc010yzb.1_RNA|CLASP1_uc010yzc.1_RNA|CLASP1_uc002tmy.2_Missense_Mutation_p.S366F	NM_015282	NP_056097	Q7Z460	CLAP1_HUMAN	CLIP-associating protein 1 isoform 1	1530	Localization to kinetochores.|Interaction with PHLDB2 and RSN.|Poly-Ser.|Interaction with CLIP2 (By similarity).				axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			ovary(1)|central_nervous_system(1)	2	Renal(3;0.0496)					ATCGGAGGAGGAGCTGCTGTT	0.488		NaN											0	0	0	0.001855	0	13	25									
GRB14	2888	broad.mit.edu	37	2	165365357	165365357	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:165365357C>T	uc002ucl.2	-	7	1363	c.822G>A	c.(820-822)CCG>CCA	p.P274P	GRB14_uc010zcv.1_Silent_p.P187P|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	274	PH.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GCAAATGCCGCGGTTCCTTAA	0.328		NaN											0	0	0	0.010504	0	20	99									
XIRP2	129446	broad.mit.edu	37	2	168103464	168103464	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:168103464G>A	uc002udx.2	+	8	5580	c.5562G>A	c.(5560-5562)CAG>CAA	p.Q1854Q	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.Q1679Q|XIRP2_uc010fpq.2_Silent_p.Q1632Q|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1679					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTGTAAATCAGAAAACAGTGA	0.388		NaN											0	0	0	0.007291	0	28	40									
TTN	7273	broad.mit.edu	37	2	179433265	179433265	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:179433265C>T	uc010zfg.1	-	275	70114	c.69890G>A	c.(69889-69891)GGT>GAT	p.G23297D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16992D|TTN_uc010zfi.1_Missense_Mutation_p.G16925D|TTN_uc010zfj.1_Missense_Mutation_p.G16800D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24224							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATATTGTCCACCATCATCCTT	0.413		NaN											0	0	0	0.00499	0	17	56									
TTN	7273	broad.mit.edu	37	2	179445285	179445285	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:179445285C>T	uc010zfg.1	-	266	59341	c.59117G>A	c.(59116-59118)CGT>CAT	p.R19706H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R13401H|TTN_uc010zfi.1_Missense_Mutation_p.R13334H|TTN_uc010zfj.1_Missense_Mutation_p.R13209H|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20633							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTCCAGCACGTAATATGAG	0.378		NaN											0	0	0	0.001984	0	6	25									
TTN	7273	broad.mit.edu	37	2	179578722	179578722	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:179578722T>C	uc010zfg.1	-	89	23155	c.22931A>G	c.(22930-22932)AAG>AGG	p.K7644R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K4305R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8571							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.K7644R(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGATGATCTTAAGGCCGGA	0.443		NaN											0	0	0	0.004482	0	9	26									
ITGA4	3676	broad.mit.edu	37	2	182339776	182339776	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:182339776G>A	uc002unu.2	+	3	1172	c.409G>A	c.(409-411)GAA>AAA	p.E137K	ITGA4_uc010zfl.1_Missense_Mutation_p.E137K	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	137	FG-GAP 2.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ACAGCCAGGAGAAAATGGATC	0.458		NaN											0	0	0	0.00308	0	6	26									
CPS1	1373	broad.mit.edu	37	2	211473145	211473145	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:211473145G>C	uc002vee.3	+	19	2385	c.2253G>C	c.(2251-2253)AAG>AAC	p.K751N	CPS1_uc010fur.2_Missense_Mutation_p.K757N|CPS1_uc010fus.2_Missense_Mutation_p.K300N	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	751					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CAGAAATTAAGAACGTCGTAT	0.423		NaN											0	0	0	0.005524	0	37	51									
SPEG	10290	broad.mit.edu	37	2	220353543	220353543	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:220353543C>T	uc010fwg.2	+	34	8070	c.8070C>T	c.(8068-8070)TAC>TAT	p.Y2690Y		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2690	Fibronectin type-III 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCAGACCTACCAGGACACGG	0.612		NaN											0	0	0	0.00245	0	14	24									
CCDC140	151278	broad.mit.edu	37	2	223168711	223168711	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr2:223168711G>A	uc002vnb.1	+	2	474	c.90G>A	c.(88-90)GCG>GCA	p.A30A		NM_153038	NP_694583	Q96MF4	CC140_HUMAN	coiled-coil domain containing 140	30											0		Renal(207;0.0376)		Epithelial(121;4.03e-10)|all cancers(144;1.8e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGAGGCTGCGAATGAGTCCA	0.547		NaN											0	0	0	0.00874	0	41	66									
SIRPG	55423	broad.mit.edu	37	20	1638344	1638344	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:1638344G>A	uc002wfm.1	-	1	82	c.17C>T	c.(16-18)TCC>TTC	p.S6F	SIRPG_uc002wfn.1_Missense_Mutation_p.S6F|SIRPG_uc002wfo.1_Missense_Mutation_p.S6F	NM_018556	NP_061026	Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma isoform 1	6					blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			ovary(1)	1						ATGGGGCCAGGAGGCTGGGAC	0.557		NaN											0	0	0	0.01441	0	72	48									
FASTKD5	60493	broad.mit.edu	37	20	3128585	3128585	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:3128585C>T	uc002whz.2	-	2	1443	c.1132G>A	c.(1132-1134)GGA>AGA	p.G378R	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	378					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						GCTATCTCTCCAATCTGCTTC	0.443		NaN											0	0	0	0.009535	0	32	133									
PLCB1	23236	broad.mit.edu	37	20	8678319	8678319	+	Silent	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:8678319G>C	uc002wnb.2	+	11	1059	c.1056G>C	c.(1054-1056)GTG>GTC	p.V352V	PLCB1_uc010zrb.1_Silent_p.V251V|PLCB1_uc002wna.2_Silent_p.V352V|PLCB1_uc002wnc.1_Silent_p.V251V	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	352	PI-PLC X-box.			V -> A (in Ref. 2; AAF86613).	activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						ATCGCCAAGTGCTCCTGTCTG	0.512		NaN											0	0	0	0.01441	0	116	39									
SLC24A3	57419	broad.mit.edu	37	20	19677543	19677543	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:19677543G>C	uc002wrl.2	+	14	1791	c.1594G>C	c.(1594-1596)GTG>CTG	p.V532L		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	532	Cytoplasmic (Potential).|Alpha-2.					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						CAGCCTCATTGTGGCCAGACA	0.383		NaN											0	0	0	0.01441	0	55	15									
MYLK2	85366	broad.mit.edu	37	20	30408244	30408244	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:30408244C>T	uc002wwq.2	+	3	470	c.368C>T	c.(367-369)CCT>CTT	p.P123L		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	123					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGCCAGGATCCTGGAAAGCCC	0.657		NaN											0	0	0	0.006999	0	39	112									
PLAGL2	5326	broad.mit.edu	37	20	30784258	30784258	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:30784258C>T	uc002wxn.2	-	3	1705	c.1488G>A	c.(1486-1488)CAG>CAA	p.Q496Q		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	496						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GTGGGGGCTACTGGAATGCTT	0.577		NaN											0	0	0	0.01441	0	58	202									
MYH7B	57644	broad.mit.edu	37	20	33575921	33575921	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:33575921C>G	uc002xbi.1	+	17	1661	c.1569C>G	c.(1567-1569)ATC>ATG	p.I523M	MIR499_hsa-mir-499|MI0003183_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	481	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity	p.I523M(1)		ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGCTGTGCATCAACTTCACCA	0.562		NaN											0	0	0	0.01441	0	170	175									
C20orf132	140699	broad.mit.edu	37	20	35731106	35731106	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:35731106C>T	uc010zvu.1	-	26	3234	c.3143G>A	c.(3142-3144)GGC>GAC	p.G1048D	C20orf132_uc002xgk.2_Missense_Mutation_p.G670D	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:Variant_position_missing_in_Q9H579_after_alignment											0		Myeloproliferative disorder(115;0.00878)				AGAGGACCTGCCCATGAGCTT	0.512		NaN											0	0	0	0.01441	0	208	525									
PLCG1	5335	broad.mit.edu	37	20	39797452	39797452	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:39797452G>A	uc002xjp.1	+	21	2546	c.2425G>A	c.(2425-2427)GAG>AAG	p.E809K	PLCG1_uc002xjo.1_Missense_Mutation_p.E809K|PLCG1_uc010zwe.1_Missense_Mutation_p.E435K|PLCG1_uc010ggf.2_Missense_Mutation_p.E133K	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	809	SH3.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GAGGGAGGACGAGCTGACCTT	0.577		NaN											0	0	0	0.00623	0	37	29									
PTPRT	11122	broad.mit.edu	37	20	40790057	40790057	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:40790057C>A	uc002xkg.2	-	17	2801	c.2617G>T	c.(2617-2619)GAC>TAC	p.D873Y	PTPRT_uc010ggj.2_Missense_Mutation_p.D892Y|PTPRT_uc010ggi.2_Missense_Mutation_p.D76Y	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	873	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGCAGCAAGTCAGCCACCCGG	0.597		NaN											1	0	5.25376e-55	0.01441	5.73252e-55	96	79									
EYA2	2139	broad.mit.edu	37	20	45633580	45633580	+	Splice_Site	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:45633580G>C	uc002xsm.2	+	4	530	c.156_splice	c.e4-1	p.R52_splice	EYA2_uc010ghp.2_Splice_Site_p.R52_splice|EYA2_uc002xsn.2_Splice_Site_p.R57_splice|EYA2_uc002xso.2_Splice_Site_p.R52_splice|EYA2_uc002xsp.2_Splice_Site_p.R52_splice|EYA2_uc002xsq.2_Splice_Site_p.R52_splice	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a						DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				TTTCCACACAGATCTTGCCCA	0.552		NaN											0	0	0	0.01441	0	93	71									
ARFGEF2	10564	broad.mit.edu	37	20	47592610	47592610	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:47592610G>A	uc002xtx.3	+	14	1984	c.1832G>A	c.(1831-1833)AGA>AAA	p.R611K		NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	611					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			GACATGGCAAGACGGTGTAGT	0.507		NaN											0	0	0	0.010729	0	12	85									
DIDO1	11083	broad.mit.edu	37	20	61511837	61511837	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:61511837C>G	uc002ydr.1	-	16	5735	c.5471G>C	c.(5470-5472)AGA>ACA	p.R1824T	DIDO1_uc002yds.1_Missense_Mutation_p.R1824T	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1824	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					TGAGGGGCCTCTGCTGTCCCC	0.617		NaN											0	0	0	0.01441	0	482	358									
CHRNA4	1137	broad.mit.edu	37	20	61981890	61981890	+	Silent	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:61981890G>C	uc002yes.2	-	5	1051	c.873C>G	c.(871-873)CTC>CTG	p.L291L	CHRNA4_uc002yet.1_Silent_p.L115L|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.L220L|CHRNA4_uc002yev.1_Silent_p.L115L|CHRNA4_uc010gkf.1_Silent_p.L115L	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	291	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TCTCGGTGATGAGCAGCAGGA	0.592		NaN											0	0	0	0.01441	0	76	453									
ZBTB46	140685	broad.mit.edu	37	20	62421703	62421703	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr20:62421703G>A	uc002ygv.1	-	2	609	c.408C>T	c.(406-408)GAC>GAT	p.D136D	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CATCTGAGGCGTCCGACTTGA	0.617		NaN											0	0	0	0.016522	0	22	151									
TMPRSS15	5651	broad.mit.edu	37	21	19715873	19715873	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr21:19715873C>T	uc002ykw.2	-	12	1409	c.1378G>A	c.(1378-1380)GAC>AAC	p.D460N		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	460	Extracellular (Potential).|MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTCCAATTGTCTCCATAATTT	0.294		NaN											0	0	0	0.01441	0	378	71									
SETD4	54093	broad.mit.edu	37	21	37429482	37429482	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr21:37429482C>G	uc002yuw.1	-	2	1467	c.94G>C	c.(94-96)GAA>CAA	p.E32Q	SETD4_uc002yux.1_Missense_Mutation_p.E8Q|SETD4_uc002yuu.2_RNA|SETD4_uc002yuv.2_Missense_Mutation_p.E32Q|SETD4_uc002yuy.2_Missense_Mutation_p.E32Q|SETD4_uc002yuz.2_Missense_Mutation_p.E8Q|SETD4_uc002yva.2_Missense_Mutation_p.E8Q	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	32										large_intestine(1)|ovary(1)	2						TCTATAAATTCAGACTTGTGG	0.398		NaN											0	0	0	0.00333	0	25	106									
BRWD1	54014	broad.mit.edu	37	21	40578084	40578084	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr21:40578084G>C	uc002yxk.1	-	37	4453	c.4314C>G	c.(4312-4314)TTC>TTG	p.F1438L	BRWD1_uc010goc.1_Missense_Mutation_p.F81L|BRWD1_uc002yxl.2_Missense_Mutation_p.F1438L|BRWD1_uc010god.1_Missense_Mutation_p.F356L	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GCCGTTGCTTGAACCTCTGGC	0.303		NaN											0	0	0	0.01441	0	55	230									
COL6A2	1292	broad.mit.edu	37	21	47531978	47531978	+	Silent	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr21:47531978C>G	uc002zia.1	+	3	283	c.201C>G	c.(199-201)CTC>CTG	p.L67L	COL6A2_uc002zhy.1_Silent_p.L67L|COL6A2_uc002zhz.1_Silent_p.L67L|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	67	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACATCCTGCTCTTCCACATGA	0.617		NaN											0	0	0	0.01441	0	53	179									
CCT8L2	150160	broad.mit.edu	37	22	17072001	17072001	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:17072001C>T	uc002zlp.1	-	1	1700	c.1440G>A	c.(1438-1440)GTG>GTA	p.V480V		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	480					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTTCAGTTCCCACACCCATTA	0.512		NaN											0	0	0	0.01441	0	118	225									
TXNRD2	10587	broad.mit.edu	37	22	19870908	19870908	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:19870908C>T	uc011ahc.1	-	12	1059	c.1026G>A	c.(1024-1026)CTG>CTA	p.L342L	TXNRD2_uc002zql.1_Silent_p.L96L|TXNRD2_uc002zqm.1_RNA|TXNRD2_uc002zqn.1_RNA|TXNRD2_uc002zqo.1_RNA|TXNRD2_uc002zqp.1_RNA|TXNRD2_uc002zqr.1_Silent_p.L341L|TXNRD2_uc002zqj.1_RNA|TXNRD2_uc002zqq.1_5'Flank	NM_006440	NP_006431	Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2 precursor	342					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			ovary(2)	2	Colorectal(54;0.0993)					GGGAGTCCACCAGGATCTTCT	0.617		NaN											0	0	0	0.01441	0	148	217									
TRMT2A	27037	broad.mit.edu	37	22	20100675	20100675	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:20100675G>A	uc002zrk.1	-	11	1730	c.1515C>T	c.(1513-1515)CTC>CTT	p.L505L	TRMT2A_uc002zrl.1_Silent_p.L505L|TRMT2A_uc002zrm.1_Silent_p.L327L|TRMT2A_uc002zrn.1_Silent_p.L523L	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	505					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						GGATGGCCACGAGGTGCTGGG	0.612		NaN											0	0	0	0.01441	0	88	172									
LARGE	9215	broad.mit.edu	37	22	33777913	33777913	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:33777913C>A	uc003and.3	-	10	1702	c.1123G>T	c.(1123-1125)GAT>TAT	p.D375Y	LARGE_uc011amd.1_Missense_Mutation_p.D174Y|LARGE_uc003ane.3_Missense_Mutation_p.D375Y|LARGE_uc010gwp.2_Missense_Mutation_p.D375Y|LARGE_uc011ame.1_Missense_Mutation_p.D307Y|LARGE_uc011amf.1_Missense_Mutation_p.D375Y|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	375	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				ACCTTTAGATCAGACACGTCT	0.562		NaN											1	0	3.57733e-08	0.009535	3.69928e-08	30	145									
LARGE	9215	broad.mit.edu	37	22	33780253	33780253	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:33780253C>A	uc003and.3	-	9	1509	c.930G>T	c.(928-930)ATG>ATT	p.M310I	LARGE_uc011amd.1_Missense_Mutation_p.M109I|LARGE_uc003ane.3_Missense_Mutation_p.M310I|LARGE_uc010gwp.2_Missense_Mutation_p.M310I|LARGE_uc011ame.1_Missense_Mutation_p.M242I|LARGE_uc011amf.1_Missense_Mutation_p.M310I|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	310	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				GCTCCCATTTCATCTTCCGCA	0.493		NaN											1	0	1.31726e-23	0.01441	1.40364e-23	60	101									
NOL12	79159	broad.mit.edu	37	22	38087186	38087186	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:38087186C>G	uc003atp.2	+	6	541	c.485C>G	c.(484-486)TCC>TGC	p.S162C	NOL12_uc011anm.1_3'UTR|NOL12_uc003ato.1_RNA|TRIOBP_uc003atq.1_5'UTR	NM_024313	NP_077289	Q9UGY1	NOL12_HUMAN	nucleolar protein 12	162						nucleolus	rRNA binding				0	Melanoma(58;0.0574)					CCTAGGATCTCCTCCCTCACA	0.577		NaN											0	0	0	0.01441	0	67	141									
SCO2	9997	broad.mit.edu	37	22	50962178	50962178	+	Silent	SNP	G	G	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:50962178G>T	uc003bma.2	-	2	839	c.663C>A	c.(661-663)ATC>ATA	p.I221I	SCO2_uc003blz.3_Silent_p.I221I	NM_005138	NP_005129	O43819	SCO2_HUMAN	cytochrome oxidase deficient homolog 2	221	Thioredoxin.				cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding				0		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AGTGGTCCACGATGTAGTCCT	0.572		NaN											1	0	4.83248e-46	0.01441	5.24769e-46	75	433									
SEC13	6396	broad.mit.edu	37	3	10354378	10354378	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:10354378G>A	uc003bvn.2	-	4	320	c.201C>T	c.(199-201)CAC>CAT	p.H67H	SEC13_uc003bvl.2_5'UTR|SEC13_uc003bvm.2_Silent_p.H53H|SEC13_uc003bvp.2_Silent_p.H70H|SEC13_uc003bvo.2_Silent_p.H113H|SEC13_uc003bvq.1_Silent_p.H53H|SEC13_uc003bvr.1_Silent_p.H53H|SEC13_uc011aul.1_Silent_p.H67H	NM_183352	NP_899195	P55735	SEC13_HUMAN	SEC13 protein isoform 1	67	WD 2.				COPII vesicle coating|intracellular protein transport|mitotic prometaphase|mRNA transport|post-translational protein modification|protein N-linked glycosylation via asparagine|transmembrane transport	cytosol|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Nup107-160 complex	protein binding			ovary(1)	1						CGTACATGGGGTGAGCCCAGG	0.562		NaN											0	0	0	0.010818	0	28	180									
LAMB2	3913	broad.mit.edu	37	3	49169709	49169709	+	Missense_Mutation	SNP	C	C	G	rs1131783		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:49169709C>G	uc003cwe.2	-	3	678	c.379G>C	c.(379-381)GAG>CAG	p.E127Q	LAMB2_uc003cwf.1_Missense_Mutation_p.E127Q	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	127	Laminin N-terminal.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCACCATTCTCTGACTGCCAC	0.602		NaN											0	0	0	0.01441	0	61	35									
CCDC71	64925	broad.mit.edu	37	3	49201104	49201104	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:49201104C>G	uc003cwg.3	-	2	676	c.538G>C	c.(538-540)GAG>CAG	p.E180Q		NM_022903	NP_075054	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	180										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ACCAGGGCCTCAAGGACAACA	0.587		NaN											0	0	0	0.01441	0	118	58									
ZPLD1	131368	broad.mit.edu	37	3	102195877	102195877	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:102195877C>T	uc003dvs.1	+	17	1946	c.1064C>T	c.(1063-1065)TCG>TTG	p.S355L	ZPLD1_uc003dvt.1_Missense_Mutation_p.S371L|ZPLD1_uc011bhg.1_Missense_Mutation_p.S355L	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	355	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						ACCAACAATTCGCAACTTGGT	0.308		NaN											0	0	0	0.013114	0	41	93									
PLCXD2	257068	broad.mit.edu	37	3	111394145	111394145	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:111394145C>A	uc003dya.2	+	1	639	c.53C>A	c.(52-54)TCC>TAC	p.S18Y	PLCXD2_uc003dyb.2_Missense_Mutation_p.S18Y|PLCXD2_uc003dxz.2_Missense_Mutation_p.S18Y	NM_001134478	NP_001127950	Q0VAA5	PLCX2_HUMAN	phosphatidylinositol-specific phospholipase C, X	18					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(1)	1						ACCATCTGCTCCCCCAACCCC	0.582		NaN											1	0	3.90053e-15	0.012213	4.1273e-15	30	179									
KIAA2018	205717	broad.mit.edu	37	3	113379606	113379606	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:113379606G>A	uc003eam.2	-	7	1334	c.923C>T	c.(922-924)TCA>TTA	p.S308L	KIAA2018_uc003eal.2_Missense_Mutation_p.S252L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	308					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GGCAGTTGCTGAGGAGCTGTG	0.413		NaN											0	0	0	0.01441	0	50	77									
KTELC1	56983	broad.mit.edu	37	3	119209463	119209463	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:119209463C>A	uc003ecm.2	+	9	947	c.863C>A	c.(862-864)TCA>TAA	p.S288*	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_Nonsense_Mutation_p.S129*	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	288						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		CTGTGTGGCTCACTTGTTTTC	0.413		NaN											1	0	3.76114e-14	0.004289	3.97057e-14	37	215									
EEFSEC	60678	broad.mit.edu	37	3	128126998	128126998	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:128126998G>A	uc003eki.2	+	7	1725	c.1687G>A	c.(1687-1689)GAG>AAG	p.E563K	EEFSEC_uc003ekj.2_3'UTR	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	563						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						CACCAGGCAGGAGGAGAGCGC	0.642		NaN											0	0	0	0.01441	0	101	123									
PCOLCE2	26577	broad.mit.edu	37	3	142539827	142539827	+	Missense_Mutation	SNP	G	G	C	rs2304735		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:142539827G>C	uc003evd.2	-	8	1206	c.1010C>G	c.(1009-1011)TCG>TGG	p.S337W		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	337	NTR.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						GTTGATGATCGAGACTGTGGC	0.502		NaN											0	0	0	0.008361	0	29	48									
ZIC1	7545	broad.mit.edu	37	3	147130454	147130454	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:147130454C>T	uc003ewe.2	+	2	1851	c.1132C>T	c.(1132-1134)CGC>TGC	p.R378C		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	378	C2H2-type 5.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAGTTCGCTGCGCAAACACAT	0.597		NaN											0	0	0	0.01441	0	61	396									
SLC33A1	9197	broad.mit.edu	37	3	155546144	155546144	+	Missense_Mutation	SNP	G	G	A	rs149578822		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:155546144G>A	uc003fan.3	-	6	1886	c.1505C>T	c.(1504-1506)TCA>TTA	p.S502L	SLC33A1_uc003fao.1_Missense_Mutation_p.S502L	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	502	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGTAACACATGAGCCACCCAG	0.313		NaN											0	0	0	0.01441	0	51	55									
PIK3CA	5290	broad.mit.edu	37	3	178928079	178928079	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq;WGS			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:178928079G>C	uc003fjk.2	+	8	1514	c.1357G>C	c.(1357-1359)GAA>CAA	p.E453Q		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	453	C2 PI3K-type.		E -> Q (in cancer; shows an increase in lipid kinase activity; may disrupt the interaction of the C2 PI3K-type domain with the iSH2 region of the p85 regulatory subunit).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E453K(5)|p.E453Q(1)|p.E453A(1)|p.P449_L455del(1)|p.G451_L456>V(1)|p.E453del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCATGGATTAGAAGATTTGCT	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	0.01441	0	82	74									
MCCC1	56922	broad.mit.edu	37	3	182759419	182759419	+	Silent	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:182759419T>C	uc003fle.2	-	11	1340	c.1203A>G	c.(1201-1203)CCA>CCG	p.P401P	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Silent_p.P284P|MCCC1_uc003flg.2_Silent_p.P292P|MCCC1_uc011bqp.1_Silent_p.P354P	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	401	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	GGTGCACTAATGGGCCTGCCA	0.458		NaN											0	0	0	0.01441	0	71	99									
EIF4G1	1981	broad.mit.edu	37	3	184041700	184041700	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:184041700G>C	uc003fnp.2	+	16	2605	c.2407G>C	c.(2407-2409)GAG>CAG	p.E803Q	EIF4G1_uc003fno.1_Missense_Mutation_p.E744Q|EIF4G1_uc010hxw.1_Missense_Mutation_p.E639Q|EIF4G1_uc003fnt.2_Missense_Mutation_p.E514Q|EIF4G1_uc003fnq.2_Missense_Mutation_p.E716Q|EIF4G1_uc003fnr.2_Missense_Mutation_p.E639Q|EIF4G1_uc010hxx.2_Missense_Mutation_p.E810Q|EIF4G1_uc003fns.2_Missense_Mutation_p.E763Q|EIF4G1_uc010hxy.2_Missense_Mutation_p.E810Q|EIF4G1_uc003fnv.3_Missense_Mutation_p.E804Q|EIF4G1_uc003fnu.3_Missense_Mutation_p.E803Q|EIF4G1_uc003fnw.2_Missense_Mutation_p.E810Q|EIF4G1_uc003fnx.2_Missense_Mutation_p.E608Q|EIF4G1_uc003fny.3_Missense_Mutation_p.E607Q|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	803	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCTCATTTTTGAGAAGGCCAT	0.517		NaN											0	0	0	0.01441	0	117	297									
EPHB3	2049	broad.mit.edu	37	3	184299313	184299313	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:184299313G>T	uc003foz.2	+	16	3337	c.2900G>T	c.(2899-2901)CGT>CTT	p.R967L		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	967	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			GACCTGCTCCGTATTGGGGTC	0.607		NaN											1	0	2.44813e-32	0.01441	2.63334e-32	58	72									
MAP3K13	9175	broad.mit.edu	37	3	185146688	185146688	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:185146688G>A	uc010hyf.2	+	3	585	c.319G>A	c.(319-321)GGA>AGA	p.G107R	MAP3K13_uc011brt.1_Intron|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Intron|MAP3K13_uc003fpi.2_Missense_Mutation_p.G107R|MAP3K13_uc010hyg.2_5'UTR	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	107					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			CACGGTGGACGGAGAGAGCAC	0.517		NaN											0	0	0	0.014323	0	22	60									
ZNF721	170960	broad.mit.edu	37	4	437033	437033	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:437033T>G	uc003gag.2	-	3	1914	c.1223A>C	c.(1222-1224)AAG>ACG	p.K408T	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.K440T|ZNF721_uc010ibe.2_Missense_Mutation_p.K396T	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	408						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GTGAATTCTCTTATGTGCAGT	0.393		NaN											0	0	0	0.013726	0	34	46									
MXD4	10608	broad.mit.edu	37	4	2252408	2252408	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:2252408C>G	uc003geu.1	-	6	525	c.493G>C	c.(493-495)GAG>CAG	p.E165Q		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	165					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						GGGCCAAACTCCATGCCCTCT	0.607		NaN											0	0	0	0.01441	0	47	96									
MXD4	10608	broad.mit.edu	37	4	2252892	2252892	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:2252892C>G	uc003geu.1	-	5	423	c.391G>C	c.(391-393)GAG>CAG	p.E131Q		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	131					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						GACAGCTGCTCCAGGCGCCGC	0.677		NaN											0	0	0	0.015359	0	26	45									
HTRA3	94031	broad.mit.edu	37	4	8284261	8284261	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:8284261G>A	uc003gla.2	+	2	687	c.483G>A	c.(481-483)CTG>CTA	p.L161L	HTRA3_uc003gkz.2_Silent_p.L161L	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	161					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						AGCTCTTCCTGAGGTGGGTGA	0.617		NaN											0	0	0	0.006999	0	38	44									
ZCCHC4	29063	broad.mit.edu	37	4	25351119	25351119	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:25351119C>T	uc003grl.3	+	7	801	c.765C>T	c.(763-765)GCC>GCT	p.A255A	ZCCHC4_uc003grm.1_RNA|ZCCHC4_uc003grn.3_Silent_p.A21A	NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	255							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				TCCAGACTGCCCTTGAAGTAT	0.408		NaN											0	0	0	0.01441	0	54	101									
SHISA3	152573	broad.mit.edu	37	4	42403228	42403228	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:42403228C>T	uc003gwp.2	+	2	695	c.477C>T	c.(475-477)TCC>TCT	p.S159S		NM_001080505	NP_001073974	A0PJX4	SHSA3_HUMAN	shisa homolog 3 precursor	159	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|skin(1)	2						GGGCACCCTCCCGGCAGTCCA	0.672		NaN											0	0	0	0.01441	0	95	267									
GABRG1	2565	broad.mit.edu	37	4	46043250	46043250	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:46043250C>A	uc003gxb.2	-	9	1305	c.1153G>T	c.(1153-1155)GGA>TGA	p.G385*		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	385	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AGAGTGGATCCAGGATGGAGA	0.388		NaN											1	0	7.16444e-05	0.003954	7.26018e-05	25	21									
GABRB1	2560	broad.mit.edu	37	4	47427997	47427997	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:47427997C>T	uc003gxh.2	+	9	1761	c.1387C>T	c.(1387-1389)CTT>TTT	p.L463F	GABRB1_uc011bze.1_Missense_Mutation_p.L393F	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	463	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CACCTTTTCTCTTTTTAATGT	0.428		NaN											0	0	0	0.01441	0	70	89									
AGXT2L1	64850	broad.mit.edu	37	4	109677623	109677623	+	Missense_Mutation	SNP	G	G	A	rs112469981		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:109677623G>A	uc003hzc.2	-	4	542	c.361C>T	c.(361-363)CGC>TGC	p.R121C	AGXT2L1_uc010imc.2_Missense_Mutation_p.R115C|AGXT2L1_uc011cfm.1_Missense_Mutation_p.R81C|AGXT2L1_uc011cfn.1_Missense_Mutation_p.R48C|AGXT2L1_uc011cfo.1_Missense_Mutation_p.R63C	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	121					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		CGAGCCAGGCGTAAGGCTAAG	0.403		NaN											0	0	0	0.008871	0	17	61									
ALPK1	80216	broad.mit.edu	37	4	113352240	113352240	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:113352240C>G	uc003iap.3	+	11	1816	c.1537C>G	c.(1537-1539)CAA>GAA	p.Q513E	ALPK1_uc003ian.3_Missense_Mutation_p.Q513E|ALPK1_uc011cfx.1_Missense_Mutation_p.Q435E|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.Q341E	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	513							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GCCACATTGTCAAAGAGACAC	0.408		NaN											0	0	0	0.008361	0	30	29									
USP53	54532	broad.mit.edu	37	4	120181753	120181753	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:120181753C>G	uc003ics.3	+	10	1833	c.767C>G	c.(766-768)TCT>TGT	p.S256C	USP53_uc003icr.3_Missense_Mutation_p.S256C|USP53_uc003icu.3_5'UTR	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	256					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						TCCGAGCATTCTGACTTGACC	0.378		NaN											0	0	0	0.01441	0	42	44									
OTUD4	54726	broad.mit.edu	37	4	146063358	146063358	+	Silent	SNP	A	A	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:146063358A>G	uc003ika.3	-	18	1755	c.1617T>C	c.(1615-1617)TTT>TTC	p.F539F	OTUD4_uc003ijz.3_Silent_p.F538F	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	603							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					CTGTTGGTCCAAAAGTTGTAG	0.468		NaN											0	0	0	0.01441	0	53	170									
CCDC110	256309	broad.mit.edu	37	4	186380089	186380089	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:186380089T>C	uc003ixu.3	-	6	1728	c.1652A>G	c.(1651-1653)CAC>CGC	p.H551R	CCDC110_uc003ixv.3_Missense_Mutation_p.H514R|CCDC110_uc011ckt.1_Missense_Mutation_p.H551R	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	551	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TTGAGTTTTGTGTTCCTTACT	0.303		NaN											0	0	0	0.003163	0	13	35									
DNAH5	1767	broad.mit.edu	37	5	13913870	13913870	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:13913870G>A	uc003jfd.2	-	11	1560	c.1518C>T	c.(1516-1518)GAC>GAT	p.D506D	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	506	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TAGTGGCCATGTCTTCCAGCC	0.358		NaN							Kartagener_syndrome				0	0	0	0.01441	0	45	35									
FBXL7	23194	broad.mit.edu	37	5	15937113	15937113	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:15937113C>G	uc003jfn.1	+	4	1775	c.1294C>G	c.(1294-1296)CGG>GGG	p.R432G		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	432	LRR 10.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CAACCTCAAGCGGCTCAGCCT	0.582		NaN											0	0	0	0.012319	0	23	70									
PDZD2	23037	broad.mit.edu	37	5	32074145	32074145	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:32074145G>C	uc003jhl.2	+	18	3321	c.2933G>C	c.(2932-2934)AGA>ACA	p.R978T	PDZD2_uc003jhm.2_Missense_Mutation_p.R978T|PDZD2_uc011cnx.1_Missense_Mutation_p.R804T	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	978					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GAGTTTGACAGAGAAGGGGAC	0.607		NaN											0	0	0	0.009535	0	33	53									
WDR41	55255	broad.mit.edu	37	5	76736658	76736658	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:76736658G>C	uc003kff.1	-	9	1149	c.862C>G	c.(862-864)CAT>GAT	p.H288D	WDR41_uc011csy.1_Missense_Mutation_p.H230D|WDR41_uc011csz.1_Missense_Mutation_p.H233D|WDR41_uc011cta.1_RNA|WDR41_uc011ctb.1_RNA	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	288											0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		CATGTGAAATGATGAATAGAA	0.343		NaN											0	0	0	0.007413	0	20	33									
BRD8	10902	broad.mit.edu	37	5	137488324	137488324	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:137488324C>G	uc003lcf.1	-	21	2758	c.2703G>C	c.(2701-2703)TGG>TGC	p.W901C	BRD8_uc003lcc.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	901					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAGTTTCCCTCCAGTTGCCCA	0.517		NaN											0	0	0	0.01441	0	111	148									
TMCO6	55374	broad.mit.edu	37	5	140024595	140024595	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:140024595C>G	uc003lgl.2	+	12	1495	c.1394C>G	c.(1393-1395)TCA>TGA	p.S465*	TMCO6_uc003lgm.2_Nonsense_Mutation_p.S471*|TMCO6_uc010jft.2_Nonsense_Mutation_p.S225*|TMCO6_uc003lgn.2_Nonsense_Mutation_p.S356*|TMCO6_uc003lgo.2_Nonsense_Mutation_p.S225*|IK_uc011czk.1_5'Flank|IK_uc003lgq.2_5'Flank	NM_018502	NP_060972	Q96DC7	TMCO6_HUMAN	transmembrane and coiled-coil domains 6	465					protein import into nucleus	cytoplasm|nuclear pore	binding|protein transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCAGCAGTCAGGGCTGCAA	0.537		NaN											0	0	0	0.01441	0	72	104									
PCDHGA3	56112	broad.mit.edu	37	5	140725379	140725379	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:140725379G>A	uc003ljm.1	+	1	1779	c.1779G>A	c.(1777-1779)GCG>GCA	p.A593A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.A353A|PCDHGA3_uc011dap.1_Silent_p.A593A	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	593	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGGTGGCGGTGGACAGAG	0.692		NaN											0	0	0	0.01441	0	108	254									
PCDH1	5097	broad.mit.edu	37	5	141233792	141233792	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:141233792C>G	uc003llp.2	-	5	3646	c.3529G>C	c.(3529-3531)GAC>CAC	p.D1177H		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GTGTTCCGGTCTTCCGGGGGG	0.667		NaN											0	0	0	0.004878	0	33	31									
PCDH1	5097	broad.mit.edu	37	5	141233828	141233828	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:141233828C>G	uc003llp.2	-	5	3610	c.3493G>C	c.(3493-3495)GAG>CAG	p.E1165Q		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CCCGCAGGCTCCTGCCCTCCT	0.677		NaN											0	0	0	0.003755	0	28	27									
ADAM19	8728	broad.mit.edu	37	5	156946911	156946911	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:156946911G>C	uc003lwz.2	-	6	600	c.536C>G	c.(535-537)TCC>TGC	p.S179C	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Missense_Mutation_p.S110C	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	179					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGGGCTTGGAGTGCTCGAA	0.552		NaN											0	0	0	0.009718	0	41	150									
DOCK2	1794	broad.mit.edu	37	5	169507184	169507184	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:169507184G>A	uc003maf.2	+	50	5264	c.5184G>A	c.(5182-5184)GAG>GAA	p.E1728E	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.E1220E|DOCK2_uc003mah.2_Silent_p.E284E	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1728					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGAAGCATGAGTTCATGAGTG	0.532		NaN											0	0	0	0.00499	0	17	92									
RANBP17	64901	broad.mit.edu	37	5	170667947	170667947	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:170667947C>A	uc003mba.2	+	23	2454	c.2438C>A	c.(2437-2439)TCC>TAC	p.S813Y	RANBP17_uc003mbb.2_Missense_Mutation_p.S138Y|RANBP17_uc003mbd.2_Missense_Mutation_p.S176Y|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	813					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAGATCCTGTCCCTTGGGAGC	0.383		NaN	T	TRD@	ALL								1	0	2.46105e-21	0.010818	2.61631e-21	30	81									
MAPK9	5601	broad.mit.edu	37	5	179666936	179666936	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr5:179666936C>A	uc003mls.3	-	10	1319	c.1048G>T	c.(1048-1050)GAA>TAA	p.E350*	MAPK9_uc003mlt.3_Nonsense_Mutation_p.E350*|MAPK9_uc010jlc.2_Nonsense_Mutation_p.E350*|MAPK9_uc003mlv.3_Nonsense_Mutation_p.E350*	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	350					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCATTCTTCAATTGCATGT	0.348		NaN											1	0	1.2644e-06	0.010504	1.29573e-06	20	58									
TFAP2A	7020	broad.mit.edu	37	6	10410427	10410427	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:10410427G>A	uc003myr.2	-	2	439	c.187C>T	c.(187-189)CAG>TAG	p.Q63*	TFAP2A_uc003myq.2_Nonsense_Mutation_p.Q57*|TFAP2A_uc003mys.2_Intron|TFAP2A_uc011dih.1_Nonsense_Mutation_p.Q63*|TFAP2A_uc003myt.2_Nonsense_Mutation_p.Q59*|TFAP2A_uc003myu.1_Nonsense_Mutation_p.Q63*|TFAP2A_uc003myv.1_Nonsense_Mutation_p.Q49*|TFAP2A_uc011dii.1_Nonsense_Mutation_p.Q59*|uc003myw.2_5'Flank	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	63	Gln/Pro-rich (transactivation domain).				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				TAGATAGGCTGGTAGGGTGGG	0.657		NaN											0	0	0	0.01441	0	82	136									
TRIM27	5987	broad.mit.edu	37	6	28891284	28891284	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:28891284G>A	uc003nlr.2	-	1	485	c.126C>T	c.(124-126)CGC>CGT	p.R42R	TRIM27_uc003nls.2_Silent_p.R42R|TRIM27_uc003nlt.1_Silent_p.R42R	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	42	RING-type.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						TGCCCCAGCAGCGGGCGAGGC	0.672		NaN	T	RET	papillary thyroid								0	0	0	0.006214	0	10	42									
OR10C1	442194	broad.mit.edu	37	6	29408455	29408455	+	Silent	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:29408455C>A	uc011dlp.1	+	1	663	c.663C>A	c.(661-663)CTC>CTA	p.L221L	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCGTATCCTCGTTACCATCT	0.592		NaN											1	0	1.43987e-31	0.01441	1.54514e-31	70	265									
HLA-DRA	3122	broad.mit.edu	37	6	32407746	32407746	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:32407746C>T	uc003obh.2	+	1	100	c.19C>T	c.(19-21)CCT>TCT	p.P7S	HLA-DRA_uc003obi.2_Missense_Mutation_p.P7S	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	7					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						AAGTGGAGTCCCTGTGCTAGG	0.473		NaN							T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Kaposi_Sarcoma_Familial_Clustering_of				0	0	0	0.008871	0	17	26									
PFDN6	10471	broad.mit.edu	37	6	33257970	33257970	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:33257970G>A	uc003odt.1	+	3	199	c.84G>A	c.(82-84)TCG>TCA	p.S28S	WDR46_uc003ods.2_5'Flank|WDR46_uc011dra.1_5'Flank|WDR46_uc010juo.1_5'Flank|PFDN6_uc010jup.1_Silent_p.S28S	NM_014260	NP_055075	O15212	PFD6_HUMAN	HLA class II region expressed gene KE2	28					'de novo' posttranslational protein folding|chaperone-mediated protein complex assembly	prefoldin complex	chaperone binding|unfolded protein binding				0						AATCCATGTCGGGGAGGCAGA	0.468		NaN											0	0	0	0.00245	0	14	67									
ITPR3	3710	broad.mit.edu	37	6	33632979	33632979	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:33632979G>C	uc011drk.1	+	13	1617	c.1398G>C	c.(1396-1398)CAG>CAC	p.Q466H		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	466	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TCATCAGCCAGAATGACCGCA	0.567		NaN											0	0	0	0.01441	0	42	161									
HMGA1	3159	broad.mit.edu	37	6	34208621	34208621	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:34208621G>C	uc003oit.2	+	3	386	c.64G>C	c.(64-66)GAG>CAG	p.E22Q	HMGA1_uc011dso.1_Missense_Mutation_p.E22Q|HMGA1_uc003oiv.2_Missense_Mutation_p.E22Q|HMGA1_uc003oiw.2_Missense_Mutation_p.E22Q|HMGA1_uc003oiu.2_Missense_Mutation_p.E22Q|HMGA1_uc003oiy.2_Missense_Mutation_p.E22Q|HMGA1_uc003oiz.2_Missense_Mutation_p.E22Q|HMGA1_uc003oja.2_Missense_Mutation_p.E22Q|HMGA1_uc003oix.2_Missense_Mutation_p.E22Q|HMGA1_uc010jvl.2_RNA|HMGA1_uc003ojc.2_Missense_Mutation_p.E22Q|HMGA1_uc011dsp.1_RNA|HMGA1_uc003ojd.2_Missense_Mutation_p.E22Q	NM_145899	NP_665906	P17096	HMGA1_HUMAN	high mobility group AT-hook 1 isoform a	22	A.T hook 1.				DNA unwinding involved in replication|initiation of viral infection|interspecies interaction between organisms|loss of chromatin silencing|nucleosome disassembly|protein complex assembly|provirus integration	chromatin|cytosol|transcription factor complex	AT DNA binding|enzyme binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|protein binding|retinoid X receptor binding|sequence-specific DNA binding transcription factor activity				0						GGACGGCACTGAGAAGCGGGG	0.622		NaN	T	NaN	microfollicular thyroid adenoma| various benign mesenchymal tumors,								0	0	0	0.01441	0	78	100									
FANCE	2178	broad.mit.edu	37	6	35423591	35423591	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:35423591C>T	uc003oko.1	+	2	501	c.316C>T	c.(316-318)CGG>TGG	p.R106W	FANCE_uc010jvw.1_Missense_Mutation_p.R106W	NM_021922	NP_068741	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	106					DNA repair	nucleoplasm	protein binding			ovary(1)|lung(1)|skin(1)	3						GATGGCCGTTCGGCCATCGCT	0.607		NaN	N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.013114	0	43	121									
KHDRBS2	202559	broad.mit.edu	37	6	62688006	62688006	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:62688006G>A	uc003peg.2	-	4	695	c.448C>T	c.(448-450)CAT>TAT	p.H150Y		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding	p.H150Y(1)		skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TCCAATGCATGACTCATACGT	0.373		NaN											0	0	0	0.014323	0	19	56									
MTO1	25821	broad.mit.edu	37	6	74171644	74171644	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:74171644G>T	uc003pgy.3	+	1	191	c.67G>T	c.(67-69)GCA>TCA	p.A23S	MTO1_uc010kav.2_Missense_Mutation_p.A23S|MTO1_uc003pgz.3_Missense_Mutation_p.A23S|MTO1_uc003pha.3_5'UTR|MTO1_uc003phb.3_Intron|MTO1_uc003phc.1_5'Flank	NM_133645	NP_598400	Q9Y2Z2	MTO1_HUMAN	mitochondrial translation optimization 1 homolog	23					tRNA processing	mitochondrion	flavin adenine dinucleotide binding			ovary(3)|skin(2)|pancreas(1)	6						ATTTCCGTTGGCACGGTTGAG	0.592		NaN											1	0	1.7489e-18	0.011902	1.8549e-18	42	115									
TAAR8	83551	broad.mit.edu	37	6	132874467	132874467	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:132874467G>C	uc011ecj.1	+	1	636	c.636G>C	c.(634-636)ATG>ATC	p.M212I		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	212	Helical; Name=5; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		CCCTTGTTATGATAATTCTTT	0.328		NaN											0	0	0	0.004482	0	9	22									
SASH1	23328	broad.mit.edu	37	6	148865205	148865205	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:148865205G>C	uc003qme.1	+	18	3074	c.2599G>C	c.(2599-2601)GAA>CAA	p.E867Q	SASH1_uc011eeb.1_Missense_Mutation_p.E628Q|SASH1_uc003qmf.1_Missense_Mutation_p.E277Q	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	867							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GATTGTACCTGAAGTGCCACA	0.572		NaN											0	0	0	0.01441	0	196	111									
ULBP1	80329	broad.mit.edu	37	6	150289814	150289814	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:150289814C>G	uc003qnp.2	+	2	200	c.157C>G	c.(157-159)CAA>GAA	p.Q53E		NM_025218	NP_079494	Q9BZM6	N2DL1_HUMAN	UL16 binding protein 1 precursor	53	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|endoplasmic reticulum|MHC class I protein complex	MHC class I receptor activity			pancreas(1)	1		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.14e-11)		GTGTGAAGTTCAAGGCCTGGT	0.463		NaN											0	0	0	0.01441	0	145	73									
SYNE1	23345	broad.mit.edu	37	6	152768727	152768727	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:152768727C>T	uc010kiw.2	-	29	4137	c.3535G>A	c.(3535-3537)GAG>AAG	p.E1179K	SYNE1_uc003qot.3_Missense_Mutation_p.E1186K|SYNE1_uc003qou.3_Missense_Mutation_p.E1179K|SYNE1_uc010kjb.1_Missense_Mutation_p.E1162K|SYNE1_uc003qow.2_Missense_Mutation_p.E474K|SYNE1_uc003qox.1_Missense_Mutation_p.E695K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1179	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGAGGGTCTCACCCCTTTTG	0.423		NaN								HNSCC(10;0.0054)			0	0	0	0.01441	0	69	34									
MYCT1	80177	broad.mit.edu	37	6	153043097	153043097	+	Silent	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:153043097G>C	uc003qpd.3	+	2	425	c.417G>C	c.(415-417)CTG>CTC	p.L139L	MYCT1_uc010kjc.1_Intron|MYCT1_uc003qpc.3_Silent_p.L139L	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	139						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		ACCTCAGCCTGGCCAGTCTCA	0.493		NaN											0	0	0	0.01441	0	60	23									
PSMB1	5689	broad.mit.edu	37	6	170862293	170862293	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:170862293C>T	uc011ehe.1	-	1	125	c.38G>A	c.(37-39)AGA>AAA	p.R13K	PSMB1_uc003qxq.2_RNA|PSMB1_uc003qxr.2_5'Flank|TBP_uc003qxt.2_5'Flank|TBP_uc003qxu.2_5'Flank|TBP_uc011ehf.1_5'Flank	NM_002793	NP_002784	P20618	PSB1_HUMAN	proteasome beta 1 subunit precursor	13					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	CCCCAAGTCTCTGCCAGGAGC	0.607		NaN											0	0	0	0.004007	0	14	5									
SDK1	221935	broad.mit.edu	37	7	4051844	4051844	+	Silent	SNP	G	G	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:4051844G>T	uc003smx.2	+	16	2536	c.2397G>T	c.(2395-2397)GGG>GGT	p.G799G	SDK1_uc010kso.2_Silent_p.G75G	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	799	Fibronectin type-III 2.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGCACAACGGGGTGTTGCGTG	0.502		NaN											1	0	3.66986e-57	0.01441	4.01391e-57	89	90									
ACTB	60	broad.mit.edu	37	7	5568242	5568242	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:5568242C>T	uc003sos.3	-	3	508	c.472G>A	c.(472-474)GGG>AGG	p.G158R	ACTB_uc003sor.3_Missense_Mutation_p.G36R|ACTB_uc003sot.3_Missense_Mutation_p.G158R|ACTB_uc003soq.3_Missense_Mutation_p.G36R|ACTB_uc010ksy.2_Missense_Mutation_p.G36R	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	158					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		TGGGTGACCCCGTCACCGGAG	0.607		NaN											0	0	0	0.01441	0	84	264									
SOSTDC1	25928	broad.mit.edu	37	7	16502559	16502559	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:16502559G>A	uc003stg.2	-	2	416	c.235C>T	c.(235-237)CGT>TGT	p.R79C	SOSTDC1_uc003sth.2_Missense_Mutation_p.R103C	NM_015464	NP_056279	Q6X4U4	SOSD1_HUMAN	sclerostin domain containing 1 precursor	79	CTCK.				Wnt receptor signaling pathway					ovary(2)|central_nervous_system(1)	3	Lung NSC(10;0.185)			UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		TTGGTGGAACGCAGTTCCCGG	0.502		NaN											0	0	0	0.006999	0	40	38									
BZW2	28969	broad.mit.edu	37	7	16745684	16745684	+	Splice_Site	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:16745684G>C	uc003stl.2	+	12	1410	c.1232_splice	c.e12-1	p.E411_splice	BZW2_uc003stm.2_Splice_Site_p.E217_splice|BZW2_uc003stj.2_Splice_Site_p.E411_splice|BZW2_uc003stk.2_Splice_Site_p.E335_splice|BZW2_uc003stp.2_Splice_Site_p.E259_splice|BZW2_uc010kua.2_Splice_Site_p.E370_splice	NM_001159767	NP_001153239	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2						cell differentiation|nervous system development|RNA metabolic process		protein binding			ovary(2)	2	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		TTCTCTCCTAGAATCCGAATC	0.428		NaN											0	0	0	0.010504	0	20	59									
CDCA7L	55536	broad.mit.edu	37	7	21951271	21951271	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:21951271C>G	uc010kuk.2	-	3	387	c.267G>C	c.(265-267)CAG>CAC	p.Q89H	CDCA7L_uc003sve.3_Missense_Mutation_p.Q55H|CDCA7L_uc010kul.2_Intron|CDCA7L_uc003svf.3_Missense_Mutation_p.Q88H|CDCA7L_uc011jyk.1_Missense_Mutation_p.Q89H	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	89	PSIP1-binding.				positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						TCAGATCACTCTGCGTAAATC	0.388		NaN											0	0	0	0.01441	0	64	66									
AVL9	23080	broad.mit.edu	37	7	32623518	32623518	+	Nonstop_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:32623518G>C	uc003tcv.1	+	16	2092	c.1946G>C	c.(1945-1947)TGA>TCA	p.*649S	AVL9_uc011kai.1_Intron|uc003tcw.2_Intron|AVL9_uc010kwj.1_Missense_Mutation_p.E433Q	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	649						integral to membrane					0						GAGAAGCCTTGAGCAAGGCGT	0.522		NaN											0	0	0	0.00308	0	8	31									
PKD1L1	168507	broad.mit.edu	37	7	47894544	47894544	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:47894544G>C	uc003tny.1	-	30	4795	c.4795C>G	c.(4795-4797)CTA>GTA	p.L1599V		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1599	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TCTATCTGTAGAGATTCCTGG	0.398		NaN											0	0	0	0.01441	0	50	43									
DDC	1644	broad.mit.edu	37	7	50595941	50595941	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:50595941C>G	uc003tpf.3	-	6	694	c.608G>C	c.(607-609)GGA>GCA	p.G203A	DDC_uc010kza.2_Missense_Mutation_p.G118A|DDC_uc003tpg.3_Missense_Mutation_p.G203A	NM_000790	NP_000781	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid	203					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(2)	2	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	TAATTTCACTCCACCAATTAA	0.527		NaN											0	0	0	0.007291	0	29	102									
ZNF713	349075	broad.mit.edu	37	7	55991305	55991305	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:55991305C>G	uc003trc.1	+	3	219	c.181C>G	c.(181-183)CAG>GAG	p.Q61E	ZNF713_uc003tra.1_Missense_Mutation_p.Q74E|MRPS17_uc003trb.2_Missense_Mutation_p.Q61E	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	61	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			aatagggtatcagctttgtaa	0.214		NaN											0	0	0	0.00308	0	8	10									
ZNF735	730291	broad.mit.edu	37	7	63673568	63673568	+	Silent	SNP	A	A	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:63673568A>G	uc011kdn.1	+	2	138	c.138A>G	c.(136-138)TTA>TTG	p.L46L		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	46	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATGTGATGTTAGAGAACTACA	0.393		NaN											0	0	0	0.004007	0	16	36									
AUTS2	26053	broad.mit.edu	37	7	70255708	70255708	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:70255708C>G	uc003tvw.3	+	19	4249	c.3506C>G	c.(3505-3507)TCC>TGC	p.S1169C	AUTS2_uc003tvx.3_Missense_Mutation_p.S1145C|AUTS2_uc011keg.1_Missense_Mutation_p.S621C	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1169	His-rich.									ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CGGCTCCACTCCGTGCACCCC	0.701		NaN											0	0	0	0.003755	0	32	110									
PCLO	27445	broad.mit.edu	37	7	82546033	82546033	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:82546033T>C	uc003uhx.2	-	7	11558	c.11269A>G	c.(11269-11271)ATG>GTG	p.M3757V	PCLO_uc003uhv.2_Missense_Mutation_p.M3757V|PCLO_uc010lec.2_Missense_Mutation_p.M722V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3688					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCTCGTGCCATTGTGTTGGTT	0.473		NaN											0	0	0	0.005443	0	26	31									
GRM3	2913	broad.mit.edu	37	7	86468800	86468800	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:86468800C>G	uc003uid.2	+	4	3069	c.1970C>G	c.(1969-1971)TCA>TGA	p.S657*	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Nonsense_Mutation_p.S529*|GRM3_uc010leh.2_Nonsense_Mutation_p.S249*	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	657	Helical; Name=3; (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ATCTGTTACTCAGCCCTGCTG	0.522		NaN											0	0	0	0.005524	0	38	111									
DBF4	10926	broad.mit.edu	37	7	87537236	87537236	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:87537236G>A	uc003ujf.1	+	12	2287	c.1783G>A	c.(1783-1785)GAA>AAA	p.E595K	DBF4_uc003ujh.1_Missense_Mutation_p.E335K|DBF4_uc003ujg.1_Missense_Mutation_p.E371K|DBF4_uc011khf.1_Missense_Mutation_p.E362K	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	595					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				ACCAAATGCTGAATTTGATAA	0.308		NaN											0	0	0	0.007835	0	39	45									
ADAM22	53616	broad.mit.edu	37	7	87778343	87778343	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:87778343C>T	uc003ujn.2	+	18	1616	c.1537C>T	c.(1537-1539)CGT>TGT	p.R513C	ADAM22_uc003ujk.1_Missense_Mutation_p.R513C|ADAM22_uc003ujl.1_Missense_Mutation_p.R513C|ADAM22_uc003ujm.2_Missense_Mutation_p.R513C|ADAM22_uc003ujo.2_Missense_Mutation_p.R513C|ADAM22_uc003ujp.1_Missense_Mutation_p.R565C	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	513	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TTGTGATATTCGTGAAACGTG	0.383		NaN											0	0	0	0.001984	0	6	29									
STEAP4	79689	broad.mit.edu	37	7	87913437	87913437	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:87913437G>A	uc003ujs.2	-	2	253	c.148C>T	c.(148-150)CGA>TGA	p.R50*	STEAP4_uc010lek.2_Nonsense_Mutation_p.R50*|STEAP4_uc003ujt.2_Nonsense_Mutation_p.R50*	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	50					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					TGGGGGTTTCGACTTCCAAAA	0.438		NaN											0	0	0	0.01441	0	55	55									
SAMD9	54809	broad.mit.edu	37	7	92734156	92734156	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:92734156T>C	uc003umf.2	-	3	1511	c.1255A>G	c.(1255-1257)AAA>GAA	p.K419E	SAMD9_uc003umg.2_Missense_Mutation_p.K419E	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	419						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GGGTGGCATTTATTTGTTACA	0.328		NaN											0	0	0	0.008871	0	20	16									
PTPRZ1	5803	broad.mit.edu	37	7	121652861	121652861	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:121652861C>G	uc003vjy.2	+	12	4156	c.3761C>G	c.(3760-3762)TCT>TGT	p.S1254C	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1254	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CATATGCACTCTGCTTCACTT	0.388		NaN											0	0	0	0.013114	0	46	64									
STRA8	346673	broad.mit.edu	37	7	134925346	134925346	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:134925346G>C	uc011kpx.1	+	2	136	c.136G>C	c.(136-138)GAG>CAG	p.E46Q		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	46					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						ACAGCTGCAGGAGCTTGAGCA	0.552		NaN											0	0	0	0.003755	0	26	117									
RBM33	155435	broad.mit.edu	37	7	155511101	155511101	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:155511101C>G	uc010lqk.1	+	9	1592	c.1224C>G	c.(1222-1224)AGC>AGG	p.S408R	RBM33_uc011kvv.1_Missense_Mutation_p.S217R	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	408	Pro-rich.						nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		CAGTTCCGAGCCAGCCGAGAC	0.458		NaN											0	0	0	0.004007	0	15	65									
VIPR2	7434	broad.mit.edu	37	7	158824561	158824561	+	Splice_Site	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr7:158824561C>T	uc003woh.2	-	12	1288	c.1102_splice	c.e12-1	p.G368_splice	VIPR2_uc010lqx.2_Splice_Site	NM_003382	NP_003373	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2						cell-cell signaling	integral to plasma membrane				lung(1)|central_nervous_system(1)	2	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		CCACCAGGCCCTGCAATGAGA	0.597		NaN											0	0	0	0.01441	0	92	61									
FBXO25	26260	broad.mit.edu	37	8	385664	385664	+	Nonsense_Mutation	SNP	C	C	G	rs140242296	byFrequency	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:385664C>G	uc003wox.2	+	5	604	c.338C>G	c.(337-339)TCA>TGA	p.S113*	FBXO25_uc003woy.2_Nonsense_Mutation_p.S113*|FBXO25_uc003woz.2_Nonsense_Mutation_p.S46*|FBXO25_uc003wpa.2_5'UTR	NM_183421	NP_904357	Q8TCJ0	FBX25_HUMAN	F-box only protein 25 isoform 1	113						nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			lung(1)	1		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		TTAGACTTCTCAAGTGCAATT	0.348		NaN											0	0	0	0.01441	0	49	40									
CSMD1	64478	broad.mit.edu	37	8	3141781	3141781	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:3141781C>A	uc011kwk.1	-	26	4431	c.4041G>T	c.(4039-4041)AAG>AAT	p.K1347N	CSMD1_uc011kwj.1_Missense_Mutation_p.K739N|CSMD1_uc003wqe.2_Missense_Mutation_p.K503N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1347	Extracellular (Potential).|CUB 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACTCCACTCCTTCAGCAGGA	0.557		NaN									OREG0018505	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	6.31663e-08	0.003163	6.50241e-08	15	19									
XPO7	23039	broad.mit.edu	37	8	21840321	21840321	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:21840321G>A	uc003xaa.3	+	11	1377	c.1275G>A	c.(1273-1275)CTG>CTA	p.L425L	XPO7_uc010lti.2_Silent_p.L434L|XPO7_uc010ltk.2_Silent_p.L426L	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	425				Missing (in Ref. 3; BAA34465).	mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		ACATCATACTGAGGTAAGGAA	0.507		NaN											0	0	0	0.00623	0	40	45									
HR	55806	broad.mit.edu	37	8	21978464	21978464	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:21978464C>A	uc003xas.2	-	11	3040	c.2375G>T	c.(2374-2376)CGC>CTC	p.R792L	HR_uc003xat.2_Missense_Mutation_p.R792L	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	792							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GTTGGTGATGCGGTCATCCTG	0.672		NaN											1	0	1.9806e-07	0.014323	2.03425e-07	23	25									
BMP1	649	broad.mit.edu	37	8	22035399	22035399	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:22035399G>A	uc003xbg.2	+	6	1009	c.765G>A	c.(763-765)CAG>CAA	p.Q255Q	BMP1_uc011kzb.1_RNA|BMP1_uc003xba.2_Silent_p.Q255Q|BMP1_uc003xbb.2_Silent_p.Q255Q|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_Silent_p.Q4Q|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_Silent_p.Q4Q|BMP1_uc011kzc.1_Silent_p.Q4Q|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	255	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TGGAGCCTCAGGAGGTGGAGT	0.592		NaN											0	0	0	0.01441	0	102	369									
ADRA1A	148	broad.mit.edu	37	8	26722121	26722121	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:26722121G>C	uc003xfh.1	-	1	802	c.366C>G	c.(364-366)ATC>ATG	p.I122M	ADRA1A_uc003xfc.1_Missense_Mutation_p.I122M|ADRA1A_uc010lul.1_Missense_Mutation_p.I122M|ADRA1A_uc003xfd.1_RNA|ADRA1A_uc003xfe.1_Missense_Mutation_p.I122M|ADRA1A_uc010lum.1_Missense_Mutation_p.I122M|ADRA1A_uc003xff.1_RNA|ADRA1A_uc003xfg.1_Missense_Mutation_p.I122M	NM_000680	NP_000671	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 1	122	Helical; Name=3; (By similarity).				activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	TGTAGCGGTCGATGGAGATGA	0.627		NaN											0	0	0	0.01441	0	102	100									
NRG1	3084	broad.mit.edu	37	8	31498210	31498210	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:31498210A>G	uc003xip.2	+	1	943	c.710A>G	c.(709-711)AAG>AGG	p.K237R		NM_013962	NP_039256	Q02297	NRG1_HUMAN	neuregulin 1 isoform GGF2	22	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CGGAACCTCAAGAAGGAGGTC	0.701		NaN											0	0	0	0.006214	0	7	37									
KCNU1	157855	broad.mit.edu	37	8	36644882	36644882	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:36644882G>A	uc010lvw.2	+	2	341	c.254G>A	c.(253-255)GGA>GAA	p.G85E	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	85	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		CACTTCCAGGGACAATTTCGT	0.423		NaN											0	0	0	0.013537	0	13	12									
ANK1	286	broad.mit.edu	37	8	41519393	41519393	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:41519393C>G	uc003xok.2	-	41	5629	c.5545G>C	c.(5545-5547)GTG>CTG	p.V1849L	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Splice_Site_p.E1002_splice|ANK1_uc003xoi.2_Splice_Site_p.E1848_splice|ANK1_uc003xoj.2_Splice_Site_p.E1848_splice|ANK1_uc003xol.2_Missense_Mutation_p.V1687L|ANK1_uc003xom.2_Splice_Site_p.E1889_splice|ANK1_uc011lcl.1_Splice_Site_p.E123_splice|ANK1_uc003xod.2_Splice_Site_p.E123_splice|ANK1_uc003xoc.2_Missense_Mutation_p.V124L|ANK1_uc003xof.2_Intron|MIR486_hsa-mir-486|MI0002470_5'Flank	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1849	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TCTACAGTCACCTCCTCGTGC	0.582		NaN											0	0	0	0.011902	0	46	385									
KIAA0146	23514	broad.mit.edu	37	8	48626144	48626144	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:48626144C>A	uc003xqd.2	+	16	2291	c.2282C>A	c.(2281-2283)CCG>CAG	p.P761Q	KIAA0146_uc011ldc.1_Missense_Mutation_p.P691Q|KIAA0146_uc011ldd.1_Missense_Mutation_p.P701Q|KIAA0146_uc003xqe.2_Missense_Mutation_p.P236Q|KIAA0146_uc003xqf.2_RNA|KIAA0146_uc010lxt.2_Missense_Mutation_p.P450Q|KIAA0146_uc011ldf.1_Missense_Mutation_p.P266Q|KIAA0146_uc011ldg.1_Missense_Mutation_p.P251Q|KIAA0146_uc003xqg.1_RNA	NM_001080394	NP_001073863	Q14159	K0146_HUMAN	hypothetical protein LOC23514	761											0		Lung NSC(58;0.175)				CTGCCTGGCCCGGTGATGCTC	0.527		NaN											1	0	4.7796e-09	0.004656	4.9538e-09	24	100									
PRKDC	5591	broad.mit.edu	37	8	48719847	48719847	+	Missense_Mutation	SNP	G	G	C	rs150449253	by1000genomes	TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:48719847G>C	uc003xqi.2	-	70	9655	c.9598C>G	c.(9598-9600)CTT>GTT	p.L3200V	PRKDC_uc003xqj.2_Missense_Mutation_p.L3200V|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	3200	KIP-binding.|FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TCTTCTGGAAGAGGGGTAAGC	0.438		NaN						NHEJ					0	0	0	0.004656	0	27	130									
PRKDC	5591	broad.mit.edu	37	8	48815271	48815271	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:48815271G>C	uc003xqi.2	-	27	3184	c.3127C>G	c.(3127-3129)CAA>GAA	p.Q1043E	PRKDC_uc003xqj.2_Missense_Mutation_p.Q1043E|PRKDC_uc011ldh.1_Missense_Mutation_p.Q1043E	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1043					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGTGTTATTTGCTTAATGGAC	0.423		NaN						NHEJ					0	0	0	0.001984	0	7	54									
YTHDF3	253943	broad.mit.edu	37	8	64099876	64099876	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:64099876C>G	uc003xuy.2	+	5	1623	c.1307C>G	c.(1306-1308)TCT>TGT	p.S436C	YTHDF3_uc010lys.2_Missense_Mutation_p.S380C|YTHDF3_uc003xuz.2_Missense_Mutation_p.S380C|YTHDF3_uc003xva.2_Missense_Mutation_p.S380C|YTHDF3_uc011len.1_Missense_Mutation_p.S380C	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	436	YTH.										0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			ATTAAATACTCTATCTGGTGT	0.398		NaN											0	0	0	0.004656	0	25	88									
PREX2	80243	broad.mit.edu	37	8	68931794	68931794	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:68931794C>G	uc003xxv.1	+	3	251	c.224C>G	c.(223-225)TCA>TGA	p.S75*	PREX2_uc003xxu.1_Nonsense_Mutation_p.S75*|PREX2_uc011lez.1_Intron	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	75	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						ATGTTGTTCTCAAACATTGAA	0.363		NaN											0	0	0	0.016522	0	23	12									
TRPA1	8989	broad.mit.edu	37	8	72973899	72973899	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:72973899A>G	uc003xza.2	-	7	1080	c.905T>C	c.(904-906)GTT>GCT	p.V302A		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	302	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	GGTTGTGTTAACAATATCCAC	0.428		NaN											0	0	0	0.015359	0	31	107									
ZFHX4	79776	broad.mit.edu	37	8	77616680	77616680	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:77616680A>C	uc003yav.2	+	2	744	c.357A>C	c.(355-357)TTA>TTC	p.L119F	ZFHX4_uc003yat.1_Missense_Mutation_p.L119F|ZFHX4_uc003yau.1_Missense_Mutation_p.L119F|ZFHX4_uc003yaw.1_Missense_Mutation_p.L119F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	119						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCAGCGAGTTAGAGGACAGTG	0.483		NaN								HNSCC(33;0.089)			0	0	0	0.003954	0	25	177									
PKHD1L1	93035	broad.mit.edu	37	8	110477234	110477234	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:110477234G>T	uc003yne.2	+	49	8277	c.8173G>T	c.(8173-8175)GCA>TCA	p.A2725S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2725	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTGCACAGCAAAAGGCCT	0.468		NaN								HNSCC(38;0.096)			1	0	1.57351e-24	0.003755	1.68063e-24	36	149									
LRRC6	23639	broad.mit.edu	37	8	133623595	133623595	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:133623595G>C	uc003ytk.2	-	9	1063	c.989C>G	c.(988-990)TCT>TGT	p.S330C	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	330	CS.					cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			ATCGATTAAAGAGGTATCCAT	0.313		NaN											0	0	0	0.003954	0	24	26									
PHF20L1	51105	broad.mit.edu	37	8	133844494	133844494	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr8:133844494G>T	uc003ytt.2	+	15	2084	c.1759G>T	c.(1759-1761)GAA>TAA	p.E587*	PHF20L1_uc011lja.1_Nonsense_Mutation_p.E561*	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	587							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TTCAGACTATGAAGACAGTTC	0.368		NaN											1	0	1.45978e-39	0.01441	1.58143e-39	70	65									
PTPRD	5789	broad.mit.edu	37	9	8521491	8521491	+	Silent	SNP	T	T	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:8521491T>A	uc003zkk.2	-	19	1458	c.747A>T	c.(745-747)CCA>CCT	p.P249P	PTPRD_uc003zkp.2_Silent_p.P249P|PTPRD_uc003zkq.2_Silent_p.P249P|PTPRD_uc003zkr.2_Silent_p.P243P|PTPRD_uc003zks.2_Silent_p.P239P|PTPRD_uc003zkl.2_Silent_p.P249P|PTPRD_uc003zkm.2_Silent_p.P236P|PTPRD_uc003zkn.2_Silent_p.P249P|PTPRD_uc003zko.2_Silent_p.P246P	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	249	Extracellular (Potential).|Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CGCTTCCGCCTGGCATGATTT	0.468		NaN								TSP Lung(15;0.13)			0	0	0	0.012319	0	22	61									
RPS6	6194	broad.mit.edu	37	9	19376356	19376356	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:19376356C>A	uc003znv.1	-	6	727	c.685G>T	c.(685-687)GCG>TCG	p.A229S	RPS6_uc003znu.1_Missense_Mutation_p.A198S	NM_001010	NP_001001	P62753	RS6_HUMAN	ribosomal protein S6	229					endocrine pancreas development|glucose homeostasis|insulin receptor signaling pathway|positive regulation of apoptosis|rRNA processing|TOR signaling cascade|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding			ovary(1)	1		Colorectal(97;3.46e-05)|Myeloproliferative disorder(762;0.0255)		Lung(42;0.161)|LUSC - Lung squamous cell carcinoma(42;0.234)		CGTCTCTTCGCAATTTGTTCC	0.413		NaN											1	0	1.62565e-12	0.012213	1.70039e-12	32	119									
TEK	7010	broad.mit.edu	37	9	27169599	27169599	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:27169599C>T	uc003zqi.3	+	4	1042	c.600C>T	c.(598-600)ACC>ACT	p.T200T	TEK_uc010mjc.1_Silent_p.T53T|TEK_uc011lnn.1_Silent_p.T200T|TEK_uc011lno.1_Silent_p.T200T|TEK_uc011lnp.1_Silent_p.T96T|TEK_uc003zqj.1_Silent_p.T177T	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	200	Extracellular (Potential).				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		ACCTCTTCACCTCGGCCTTCA	0.448		NaN											0	0	0	0.00499	0	18	82									
ZBTB5	9925	broad.mit.edu	37	9	37441201	37441201	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:37441201G>C	uc003zzx.2	-	2	1548	c.1348C>G	c.(1348-1350)CCA>GCA	p.P450A		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		CCAGCCTCTGGACTCAACAAA	0.517		NaN											0	0	0	0.007291	0	28	52									
TRPM6	140803	broad.mit.edu	37	9	77376977	77376977	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:77376977G>A	uc004ajl.1	-	26	4848	c.4610C>T	c.(4609-4611)GCT>GTT	p.A1537V	TRPM6_uc004ajk.1_Missense_Mutation_p.A1532V|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.A493V	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1537	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						ATGACTCCTAGCGAAGGGCCT	0.413		NaN											0	0	0	0.00632	0	28	15									
C9orf64	84267	broad.mit.edu	37	9	86571141	86571141	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:86571141C>G	uc004anb.2	-	1	523	c.275G>C	c.(274-276)AGA>ACA	p.R92T	C9orf64_uc004anc.2_5'UTR	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	92											0						TGTTTTCCCTCTGTACCTCAC	0.592		NaN											0	0	0	0.01441	0	84	59									
FAM22G	441457	broad.mit.edu	37	9	99697725	99697725	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:99697725G>A	uc004awq.1	+	3	1544	c.829G>A	c.(829-831)GAG>AAG	p.E277K	HIATL2_uc004awr.1_Intron	NM_001045477	NP_001038942	Q5VZR2	FA22G_HUMAN	hypothetical protein LOC441457	277										skin(1)	1		Acute lymphoblastic leukemia(62;0.0527)				GATTTTCTACGAGATGGCGGC	0.652		NaN											0	0	0	0.005524	0	40	73									
BAAT	570	broad.mit.edu	37	9	104130470	104130470	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:104130470G>A	uc010mtd.2	-	3	710	c.601C>T	c.(601-603)CGC>TGC	p.R201C	BAAT_uc004bbd.3_Missense_Mutation_p.R201C	NM_001127610	NP_001121082	Q14032	BAAT_HUMAN	bile acid Coenzyme A: amino acid	201					acyl-CoA metabolic process|bile acid and bile salt transport|bile acid biosynthetic process|digestion|fatty acid metabolic process|glycine metabolic process	cytosol|peroxisomal matrix	carboxylesterase activity|glycine N-choloyltransferase activity|N-acyltransferase activity|palmitoyl-CoA hydrolase activity			ovary(1)|lung(1)|skin(1)	3		Acute lymphoblastic leukemia(62;0.0559)			Glycine(DB00145)	TCTGGTTTGCGGGGCAGGTCT	0.493		NaN											0	0	0	0.008871	0	17	56									
OR1J1	347168	broad.mit.edu	37	9	125239256	125239256	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:125239256A>G	uc011lyu.1	-	1	950	c.950T>C	c.(949-951)CTC>CCC	p.L317P	OR1J2_uc004bmj.1_Intron	NM_001004451	NP_001004451	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J,	317	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						caaagtgttgagattacaggc	0.124		NaN											0	0	0	0.001984	0	6	50									
SPTAN1	6709	broad.mit.edu	37	9	131346653	131346653	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:131346653C>T	uc004bvl.3	+	17	2399	c.2286C>T	c.(2284-2286)CTC>CTT	p.L762L	SPTAN1_uc011mbg.1_Silent_p.L762L|SPTAN1_uc011mbh.1_Silent_p.L774L|SPTAN1_uc004bvm.3_Silent_p.L762L|SPTAN1_uc004bvn.3_Silent_p.L762L	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	762	Spectrin 8.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGGAAGCCCTCGTGGCTCGCT	0.547		NaN											0	0	0	0.005443	0	25	9									
SPTAN1	6709	broad.mit.edu	37	9	131347041	131347041	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:131347041C>T	uc004bvl.3	+	18	2592	c.2479C>T	c.(2479-2481)CAA>TAA	p.Q827*	SPTAN1_uc011mbg.1_Nonsense_Mutation_p.Q827*|SPTAN1_uc011mbh.1_Nonsense_Mutation_p.Q839*|SPTAN1_uc004bvm.3_Nonsense_Mutation_p.Q827*|SPTAN1_uc004bvn.3_Nonsense_Mutation_p.Q827*	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	827	Spectrin 9.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AAAGAAACATCAAGCCTTACA	0.448		NaN											0	0	0	0.01441	0	59	25									
SEC16A	9919	broad.mit.edu	37	9	139368716	139368716	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr9:139368716G>T	uc004chx.2	-	3	3661	c.3352C>A	c.(3352-3354)CAG>AAG	p.Q1118K	SEC16A_uc004chv.3_Missense_Mutation_p.Q508K|SEC16A_uc004chw.2_Missense_Mutation_p.Q1118K|SEC16A_uc010nbn.2_Missense_Mutation_p.Q1118K|SEC16A_uc010nbo.1_Missense_Mutation_p.Q1118K	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	940	Pro-rich.|Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CTAGAGGACTGAGGAGGCCGA	0.667		NaN											1	0	4.31634e-10	0.012213	4.49413e-10	26	20									
DDX53	168400	broad.mit.edu	37	X	23019522	23019522	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:23019522G>C	uc004daj.2	+	1	1436	c.1348G>C	c.(1348-1350)GAA>CAA	p.E450Q		NM_182699	NP_874358	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	450	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			large_intestine(1)|ovary(1)|kidney(1)	3						TGTTACCACAGAAAAAGAAAA	0.353		NaN											0	0	0	0.001168	0	6	75									
FAM47A	158724	broad.mit.edu	37	X	34148659	34148659	+	Silent	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:34148659G>A	uc004ddg.2	-	1	1770	c.1737C>T	c.(1735-1737)TAC>TAT	p.Y579Y		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	579										ovary(4)|central_nervous_system(1)	5						GTTCTTTTATGTAGGATGCTC	0.483		NaN											0	0	0	0.00874	0	43	10									
RPGR	6103	broad.mit.edu	37	X	38147249	38147249	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:38147249C>G	uc004ded.1	-	14	1786	c.1618G>C	c.(1618-1620)GAA>CAA	p.E540Q	RPGR_uc004deb.2_Missense_Mutation_p.E540Q|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	540	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TCATCGTTTTCAGTAAGAGCT	0.358		NaN											0	0	0	0.01441	0	44	15									
MED14	9282	broad.mit.edu	37	X	40540142	40540142	+	Silent	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:40540142C>A	uc004dex.3	-	20	2618	c.2478G>T	c.(2476-2478)TCG>TCT	p.S826S		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	826					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						TTTGATGGATCGAATTCCATT	0.328		NaN											1	0	6.4e-05	0.004672	6.5e-05	3	14									
HUWE1	10075	broad.mit.edu	37	X	53578103	53578103	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:53578103C>T	uc004dsp.2	-	65	9546	c.9144G>A	c.(9142-9144)CAG>CAA	p.Q3048Q	HUWE1_uc004dsn.2_Silent_p.Q1856Q	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3048					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGCTGGCATTCTGTGCTAGTT	0.562		NaN											0	0	0	0.010771	0	45	15									
HUWE1	10075	broad.mit.edu	37	X	53578136	53578136	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:53578136C>G	uc004dsp.2	-	65	9513	c.9111G>C	c.(9109-9111)CAG>CAC	p.Q3037H	HUWE1_uc004dsn.2_Missense_Mutation_p.Q1845H	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3037					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GCTCAGCTCTCTGCTGTGCCA	0.577		NaN											0	0	0	0.005524	0	39	15									
TRO	7216	broad.mit.edu	37	X	54957054	54957054	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:54957054C>T	uc004dtq.2	+	12	4004	c.3897C>T	c.(3895-3897)TTC>TTT	p.F1299F	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Silent_p.F830F|TRO_uc004dtw.2_Silent_p.F902F|TRO_uc004dtx.2_Silent_p.F682F	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	1299	49.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						ATGCTAGTTTCGGCAGCACAC	0.582		NaN											0	0	0	0.01441	0	68	18									
UBQLN2	29978	broad.mit.edu	37	X	56590882	56590882	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:56590882G>C	uc004dus.2	+	1	811	c.576G>C	c.(574-576)CAG>CAC	p.Q192H	UBQLN2_uc011moq.1_Missense_Mutation_p.Q192H	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	192						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						CCTTTGTTCAGAGCATGCTTT	0.478		NaN											0	0	0	0.01441	0	59	22									
CSTF2	1478	broad.mit.edu	37	X	100086569	100086569	+	Silent	SNP	C	C	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:100086569C>A	uc004egh.2	+	9	1013	c.955C>A	c.(955-957)CGA>AGA	p.R319R	CSTF2_uc010nnd.2_Silent_p.R339R|CSTF2_uc004egi.2_Silent_p.R302R	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	319	Gly/Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						CCCAACCCCTCGAGGCTTGTT	0.532		NaN											1	0	9.82936e-54	0.01441	1.06994e-53	95	14									
ODZ1	10178	broad.mit.edu	37	X	123516590	123516590	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:123516590A>G	uc004euj.2	-	30	7413	c.7349T>C	c.(7348-7350)TTA>TCA	p.L2450S	ODZ1_uc011muj.1_Missense_Mutation_p.L2456S|ODZ1_uc010nqy.2_Missense_Mutation_p.L2457S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2450	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TAAATTTTCTAATTCAGGTTT	0.353		NaN											0	0	0	0.01441	0	100	24									
MAGEA4	4103	broad.mit.edu	37	X	151092370	151092370	+	Silent	SNP	C	C	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:151092370C>T	uc004fez.2	+	3	390	c.234C>T	c.(232-234)TTC>TTT	p.F78F	MAGEA4_uc004ffa.2_Silent_p.F78F|MAGEA4_uc004ffb.2_Silent_p.F78F|MAGEA4_uc004ffc.2_Silent_p.F78F|MAGEA4_uc004ffd.2_Silent_p.F78F	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	78							protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCATCAGCTTCACTTGCTGGA	0.602		NaN											0	0	0	0.01441	0	90	25									
CTAG2	30848	broad.mit.edu	37	X	153880627	153880627	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:153880627G>A	uc004fmi.1	-	2	601	c.548C>T	c.(547-549)CCA>CTA	p.P183L	CTAG2_uc004fmh.1_Intron	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	183	Poly-Pro.					centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGGCGGGCCTGGTGTACCAGG	0.607		NaN											0	0	0	0.01441	0	117	37									
TXNIP	10628	broad.mit.edu	37	1	145440778	145440779	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr1:145440778_145440779insA	uc001enn.3	+	6	1319_1320	c.978_979insA	c.(976-981)GATACCfs	p.D326fs	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Frame_Shift_Ins_p.D271fs	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	326_327					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ACATCCCTGATACCCCAGAAGG	0.48		NaN											NaN	NaN	NaN	NaN	NaN	34	140	---	---							
PPP1R3C	5507	broad.mit.edu	37	10	93390301	93390311	+	Frame_Shift_Del	DEL	GCAGATCCCAC	GCAGATCCCAC	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:93390301_93390311delGCAGATCCCAC	uc001kho.2	-	2	459_469	c.327_337delGTGGGATCTGC	c.(325-339)GCGTGGGATCTGCAGfs	p.A109fs		NM_005398	NP_005389	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	109_113							protein serine/threonine phosphatase activity			breast(1)	1		Colorectal(252;0.235)				AGATCAAACTGCAGATCCCACGCTGGTTCTT	0.483		NaN											NaN	NaN	NaN	NaN	NaN	104	81	---	---							
SH3PXD2A	9644	broad.mit.edu	37	10	105372779	105372780	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:105372779_105372780insG	uc001kxj.1	-	11	1144_1145	c.1004_1005insC	c.(1003-1005)CCAfs	p.P335fs	SH3PXD2A_uc010qqr.1_Frame_Shift_Ins_p.P225fs|SH3PXD2A_uc010qqs.1_Frame_Shift_Ins_p.P170fs|SH3PXD2A_uc010qqt.1_Frame_Shift_Ins_p.P212fs|SH3PXD2A_uc009xxn.1_Frame_Shift_Ins_p.P170fs|SH3PXD2A_uc010qqu.1_Frame_Shift_Ins_p.P278fs	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	363					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CGCCTTCGGCTGGTGGAGTTTC	0.589		NaN											NaN	NaN	NaN	NaN	NaN	7	463	---	---							
MKI67	4288	broad.mit.edu	37	10	129903675	129903676	+	Frame_Shift_Ins	INS	-	-	T			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr10:129903675_129903676insT	uc001lke.2	-	13	6623_6624	c.6428_6429insA	c.(6427-6429)ACCfs	p.T2143fs	MKI67_uc001lkf.2_Frame_Shift_Ins_p.T1783fs|MKI67_uc009yav.1_Frame_Shift_Ins_p.T1718fs|MKI67_uc009yaw.1_Frame_Shift_Ins_p.T1293fs	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2143	16 X 122 AA approximate repeats.|10.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTGTGTGTGTGGTCTGTGTGAG	0.495		NaN											NaN	NaN	NaN	NaN	NaN	15	478	---	---							
MTL5	9633	broad.mit.edu	37	11	68480836	68480836	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:68480836delT	uc001ooc.2	-	8	1200	c.1060delA	c.(1060-1062)ATTfs	p.I354fs		NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	354					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			CCCTTCCCAATTTTTGGCTGG	0.473		NaN											NaN	NaN	NaN	NaN	NaN	8	2935	---	---							
CCND1	595	broad.mit.edu	37	11	69465988	69465990	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr11:69465988_69465990delGAG	uc001opa.2	+	5	1035_1037	c.826_828delGAG	c.(826-828)GAGdel	p.E280del		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	280	Poly-Glu.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	ggaggaggaagaggaggaggagg	0.606		NaN	T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			NaN	NaN	NaN	NaN	NaN	8	1559	---	---							
LRRIQ1	84125	broad.mit.edu	37	12	85438589	85438590	+	Splice_Site	DEL	TA	TA	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr12:85438589_85438590delTA	uc001tac.2	+	4	447	c.336_splice	c.e4+2	p.K112_splice	LRRIQ1_uc001tab.1_Splice_Site_p.K112_splice|LRRIQ1_uc001taa.1_Splice_Site_p.K112_splice|LRRIQ1_uc001tad.2_Splice_Site_p.K20_splice	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1											ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TTAATTAAGGTATATATTCAAT	0.272		NaN											NaN	NaN	NaN	NaN	NaN	29	35	---	---							
PABPC3	5042	broad.mit.edu	37	13	25671333	25671333	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr13:25671333delA	uc001upy.2	+	1	1058	c.997delA	c.(997-999)AAAfs	p.K333fs		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	333	RRM 4.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TGGTCGCAGCAAAGGGTTTGG	0.428		NaN											NaN	NaN	NaN	NaN	NaN	7	229	---	---							
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr16:3119304_3119305insG	uc002cto.2	+	6	864_865	c.653_654insG	c.(652-654)GACfs	p.D218fs	IL32_uc002ctk.2_Frame_Shift_Ins_p.D115fs|IL32_uc010uwp.1_Frame_Shift_Ins_p.D152fs|IL32_uc010btb.2_Frame_Shift_Ins_p.D162fs|IL32_uc002ctl.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctm.2_Frame_Shift_Ins_p.D172fs|IL32_uc002ctn.2_Frame_Shift_Ins_p.D172fs|IL32_uc002cts.3_Frame_Shift_Ins_p.D172fs|IL32_uc002ctp.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctq.2_Frame_Shift_Ins_p.D218fs|IL32_uc002ctr.2_Frame_Shift_Ins_p.D152fs|IL32_uc002ctt.2_Frame_Shift_Ins_p.D172fs|IL32_uc010uwr.1_Frame_Shift_Ins_p.D132fs|IL32_uc002ctu.2_Frame_Shift_Ins_p.D163fs	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CCACGGGGGGACAAGGAGGAGC	0.574		NaN											NaN	NaN	NaN	NaN	NaN	9	607	---	---							
TP53	7157	broad.mit.edu	37	17	7579315	7579316	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			-	C	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr17:7579315_7579316insC	uc002gim.2	-	4	565_566	c.371_372insG	c.(370-372)TGCfs	p.C124fs	TP53_uc002gig.1_Frame_Shift_Ins_p.C124fs|TP53_uc002gih.2_Frame_Shift_Ins_p.C124fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Ins_p.C124fs|TP53_uc010cni.1_Frame_Shift_Ins_p.C124fs|TP53_uc002gij.2_Frame_Shift_Ins_p.C124fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Ins_p.C85fs|TP53_uc010cnk.1_Frame_Shift_Ins_p.C139fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	124	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> R (in sporadic cancers; somatic mutation).|C -> G (in a sporadic cancer; somatic mutation).|C -> Y (in a sporadic cancer; somatic mutation).|C -> W (in a sporadic cancer; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.C124R(4)|p.G59fs*23(3)|p.C124fs*46(2)|p.C124G(1)|p.V73fs*9(1)|p.T123fs*24(1)|p.C124fs*0(1)|p.G105_T125del21(1)|p.Y107fs*44(1)|p.T125fs*24(1)|p.C124S(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.C124fs*48(1)|p.C124Y(1)|p.C124fs*25(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACTGACCGTGCAAGTCACAGA	0.545		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			NaN	NaN	NaN	NaN	NaN	96	38	---	---							
SPRED3	399473	broad.mit.edu	37	19	38882864	38882866	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:38882864_38882866delCCT	uc002oim.2	+	3	363_365	c.359_361delCCT	c.(358-363)CCCTCC>CCC	p.S128del	SPRED3_uc002oil.1_In_Frame_Del_p.S128del	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	128	Ser-rich.				multicellular organismal development					central_nervous_system(2)|lung(1)|skin(1)	4	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCACTCAccccctcctcctcctc	0.537		NaN											NaN	NaN	NaN	NaN	NaN	12	169	---	---							
FAM98C	147965	broad.mit.edu	37	19	38899502	38899504	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:38899502_38899504delAAG	uc002oin.1	+	8	1049_1051	c.1030_1032delAAG	c.(1030-1032)AAGdel	p.K349del	FAM98C_uc002oio.1_In_Frame_Del_p.K267del|FAM98C_uc010xtz.1_3'UTR	NM_174905	NP_777565	Q17RN3	FA98C_HUMAN	hypothetical protein LOC147965	349										skin(1)	1	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TTGGGGTCGCAAGAAGAAGAAGA	0.606		NaN											NaN	NaN	NaN	NaN	NaN	13	249	---	---							
RSPH6A	81492	broad.mit.edu	37	19	46299147	46299149	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr19:46299147_46299149delCCT	uc002pdm.2	-	6	2275_2277	c.2132_2134delAGG	c.(2131-2136)GAGGGC>GGC	p.E711del	RSPH6A_uc002pdl.2_In_Frame_Del_p.E447del	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	711	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						GTctcctcgccctcctcctcctc	0.409		NaN											NaN	NaN	NaN	NaN	NaN	22	739	---	---							
MED15	51586	broad.mit.edu	37	22	20920813	20920814	+	In_Frame_Ins	INS	-	-	CAG			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr22:20920813_20920814insCAG	uc002zsp.2	+	7	830_831	c.750_751insCAG	c.(748-753)insCAG	p.262_263insQ	MED15_uc002zso.2_In_Frame_Ins_p.191_192insQ|MED15_uc002zsq.2_In_Frame_Ins_p.262_263insQ|MED15_uc010gso.2_In_Frame_Ins_p.262_263insQ|MED15_uc002zsr.2_In_Frame_Ins_p.236_237insQ|MED15_uc011ahs.1_In_Frame_Ins_p.236_237insQ|MED15_uc002zss.2_In_Frame_Ins_p.181_182insQ|MED15_uc011ahu.1_5'UTR	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	262_263				Missing (in Ref. 3; BAB85034).	regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			aacaacagcaacagcagcagca	0.312		NaN											NaN	NaN	NaN	NaN	NaN	13	116	---	---							
EIF4G1	1981	broad.mit.edu	37	3	184039744	184039746	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:184039744_184039746delGAA	uc003fnp.2	+	10	1570_1572	c.1372_1374delGAA	c.(1372-1374)GAAdel	p.E465del	EIF4G1_uc003fno.1_In_Frame_Del_p.E406del|EIF4G1_uc010hxw.1_In_Frame_Del_p.E301del|EIF4G1_uc003fnt.2_In_Frame_Del_p.E176del|EIF4G1_uc003fnq.2_In_Frame_Del_p.E378del|EIF4G1_uc003fnr.2_In_Frame_Del_p.E301del|EIF4G1_uc010hxx.2_In_Frame_Del_p.E472del|EIF4G1_uc003fns.2_In_Frame_Del_p.E425del|EIF4G1_uc010hxy.2_In_Frame_Del_p.E472del|EIF4G1_uc003fnv.3_In_Frame_Del_p.E465del|EIF4G1_uc003fnu.3_In_Frame_Del_p.E465del|EIF4G1_uc003fnw.2_In_Frame_Del_p.E472del|EIF4G1_uc003fnx.2_In_Frame_Del_p.E269del|EIF4G1_uc003fny.3_In_Frame_Del_p.E269del	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	465	Poly-Glu.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGAGGAAATGgaagaagaagaag	0.443		NaN											NaN	NaN	NaN	NaN	NaN	12	668	---	---							
TNK2	10188	broad.mit.edu	37	3	195599180	195599181	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr3:195599180_195599181insG	uc003fvu.1	-	10	1960_1961	c.1417_1418insC	c.(1417-1419)CGCfs	p.R473fs	TNK2_uc003fvq.1_5'Flank|TNK2_uc003fvr.1_5'UTR|TNK2_uc003fvs.1_Frame_Shift_Ins_p.R505fs|TNK2_uc003fvt.1_Frame_Shift_Ins_p.R536fs|TNK2_uc010hzw.1_RNA|TNK2_uc003fvv.1_Frame_Shift_Ins_p.R303fs	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	473				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CCAGCAGTGGCGGGGGTCACTG	0.673		NaN											NaN	NaN	NaN	NaN	NaN	19	288	---	---							
NAP1L5	266812	broad.mit.edu	37	4	89618431	89618433	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:89618431_89618433delCCT	uc003hrx.2	-	1	591_593	c.473_475delAGG	c.(472-477)GAGGCT>GCT	p.E158del	HERC3_uc003hrw.1_Intron|HERC3_uc011cdn.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	158	Glu-rich.				nucleosome assembly	nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		TCTGCCGCAGcctcctcctcctc	0.389		NaN											NaN	NaN	NaN	NaN	NaN	7	304	---	---							
PCDH10	57575	broad.mit.edu	37	4	134072435	134072435	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr4:134072435delC	uc003iha.2	+	1	1966	c.1140delC	c.(1138-1140)TTCfs	p.F380fs	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Frame_Shift_Del_p.F380fs	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	380	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGGCCCTTTTCAGCGTGACTG	0.577		NaN											NaN	NaN	NaN	NaN	NaN	202	192	---	---							
HIST1H1A	3024	broad.mit.edu	37	6	26017448	26017448	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chr6:26017448delT	uc003nfo.2	-	1	593	c.513delA	c.(511-513)AAAfs	p.K171fs		NM_005325	NP_005316	Q02539	H11_HUMAN	histone cluster 1, H1a	171					nucleosome assembly|spermatogenesis	nucleosome|nucleus	DNA binding			ovary(2)	2						CAGTTTTGGGTTTTTTTGGAT	0.483		NaN											NaN	NaN	NaN	NaN	NaN	7	1492	---	---							
KDM6A	7403	broad.mit.edu	37	X	44950105	44950111	+	Splice_Site	DEL	ATTAAGT	ATTAAGT	-	rs148188315		TCGA-DK-A1A6-01A-11D-A13W-08	TCGA-DK-A1A6-10A-01D-A13W-08			ATTAAGT	-	ATTAAGT	ATTAAGT		Valid	Somatic	Phase_I	WXS	Fluidigm_realigned			Illumina GAIIx	df8a913c-5160-4fc5-950d-7c890e24e820	fcdb086f-6e88-49ce-a202-b611584a080c	g.chrX:44950105_44950111delATTAAGT	uc004dge.3	+	26	4253	c.3878_splice	c.e26+1	p.K1293_splice	KDM6A_uc011mkz.1_Splice_Site_p.K1345_splice|KDM6A_uc011mla.1_Splice_Site_p.K1248_splice|KDM6A_uc011mlb.1_Splice_Site_p.K1300_splice|KDM6A_uc011mlc.1_Splice_Site_p.K997_splice|KDM6A_uc011mld.1_Splice_Site_p.K932_splice	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide						histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TTTTGAAATGATTAAGTAAGTCTTTTC	0.353		NaN	D|N|F|S		renal|oesophageal SCC|MM								NaN	NaN	NaN	NaN	NaN	18	16	---	---