Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
ATAD3A	55210	broad.mit.edu	37	1	1451459	1451459	+	Silent	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:1451459C>G	uc001afz.1	+	2	367	c.273C>G	c.(271-273)TCC>TCG	p.S91S	ATAD3A_uc001aga.1_Silent_p.S91S|ATAD3A_uc001agb.1_Silent_p.S12S	NM_018188	NP_060658	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	91							ATP binding|nucleoside-triphosphatase activity|protein binding			skin(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		AGCAACAGTCCAAGCTCAAAG	0.632		NaN											0	0	0	0.00245	0	13	26									
ARHGEF16	27237	broad.mit.edu	37	1	3386012	3386012	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:3386012C>T	uc001akg.3	+	6	1125	c.877C>T	c.(877-879)CTC>TTC	p.L293F	ARHGEF16_uc001aki.2_Missense_Mutation_p.L5F|ARHGEF16_uc001akj.2_Missense_Mutation_p.L5F|ARHGEF16_uc009vli.1_5'Flank|ARHGEF16_uc010nzh.1_5'Flank	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	293	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GTTCGAGATCCTCACGTCGGA	0.627		NaN											0	0	0	0.004656	0	23	41									
AJAP1	55966	broad.mit.edu	37	1	4832502	4832502	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:4832502C>T	uc001alm.1	+	4	1461	c.1080C>T	c.(1078-1080)TGC>TGT	p.C360C	AJAP1_uc001aln.2_Silent_p.C360C	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	360	Targeting signals.|Cytoplasmic (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CTCACGAGTGCGTCAGGGCAT	0.592		NaN											0	0	0	0.006214	0	9	32									
CHD5	26038	broad.mit.edu	37	1	6189100	6189100	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:6189100C>T	uc001amb.1	-	23	3517	c.3417G>A	c.(3415-3417)CAG>CAA	p.Q1139Q	CHD5_uc001alz.1_5'UTR|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1139	Helicase C-terminal.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CCTTCTTGTTCTGGCCGATGC	0.642		NaN											0	0	0	0.008871	0	18	26									
UBE4B	10277	broad.mit.edu	37	1	10211454	10211454	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:10211454A>G	uc001aqs.3	+	21	3474	c.2761A>G	c.(2761-2763)AAC>GAC	p.N921D	UBE4B_uc001aqr.3_Missense_Mutation_p.N792D|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Missense_Mutation_p.N376D|UBE4B_uc001aqt.1_Missense_Mutation_p.N261D	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	921					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GATGTTGTGCAACCAGAACTA	0.458		NaN											0	0	0	0.00245	0	14	99									
MASP2	10747	broad.mit.edu	37	1	11097835	11097835	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:11097835T>G	uc001aru.2	-	7	944	c.923A>C	c.(922-924)AAT>ACT	p.N308T		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	308	Sushi 1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		AACGTGGCCATTAGGTGGCGC	0.502		NaN									OREG0013096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	14	68									
SPEN	23013	broad.mit.edu	37	1	16265833	16265833	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:16265833G>A	uc001axk.1	+	15	11110	c.10906G>A	c.(10906-10908)GAG>AAG	p.E3636K	SPEN_uc010obp.1_Missense_Mutation_p.E3595K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3636	SPOC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGAGTTCTCTGAGAGTCACCT	0.582		NaN											0	0	0	0.01441	0	75	156									
SPEN	23013	broad.mit.edu	37	1	16265921	16265921	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:16265921G>A	uc001axk.1	+	15	11198	c.10994G>A	c.(10993-10995)TGA>TAA	p.*3665*	SPEN_uc010obp.1_Silent_p.*3624*	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3665					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCCTCCGTGTGAGCCACTGAG	0.552		NaN											0	0	0	0.01441	0	73	124									
EPHA2	1969	broad.mit.edu	37	1	16464519	16464519	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:16464519C>T	uc001aya.1	-	5	1278	c.1141G>A	c.(1141-1143)GCC>ACC	p.A381T	EPHA2_uc010oca.1_Missense_Mutation_p.A381T	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	381	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CGCACACTGGCCTCACACGGC	0.657		NaN											0	0	0	0.001855	0	14	15									
PADI1	29943	broad.mit.edu	37	1	17565174	17565174	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:17565174G>A	uc001bah.1	+	13	1614	c.1522G>A	c.(1522-1524)GAG>AAG	p.E508K	PADI1_uc010oco.1_Missense_Mutation_p.E65K|PADI1_uc010ocp.1_Missense_Mutation_p.E65K|PADI1_uc010ocq.1_5'UTR|PADI1_uc009vpb.1_5'Flank	NM_013358	NP_037490	Q9ULC6	PADI1_HUMAN	peptidylarginine deiminase type I	508					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity				0		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	GAAGAAAGAAGAGGGTTATGG	0.607		NaN											0	0	0	0.000602	0	4	9									
EIF4G3	8672	broad.mit.edu	37	1	21212781	21212781	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:21212781A>G	uc001bec.2	-	14	2425	c.2169T>C	c.(2167-2169)GAT>GAC	p.D723D	EIF4G3_uc010odi.1_Silent_p.D327D|EIF4G3_uc010odj.1_Silent_p.D722D|EIF4G3_uc009vpz.2_Silent_p.D443D|EIF4G3_uc001bed.2_Silent_p.D723D|EIF4G3_uc001bef.2_Silent_p.D759D|EIF4G3_uc001bee.2_Silent_p.D729D	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	723	eIF3/EIF4A-binding (By similarity).				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCAGGTGTACATCTTCTTTTA	0.423		NaN											0	0	0	0.012213	0	34	139									
HNRNPR	10236	broad.mit.edu	37	1	23637803	23637803	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:23637803T>C	uc001bgr.3	-	10	1339	c.1180A>G	c.(1180-1182)ATG>GTG	p.M394V	HNRNPR_uc001bgo.2_Missense_Mutation_p.M4V|HNRNPR_uc001bgp.3_Missense_Mutation_p.M397V|HNRNPR_uc009vqk.2_Missense_Mutation_p.M296V|HNRNPR_uc001bgs.3_Missense_Mutation_p.M293V|HNRNPR_uc010odw.1_Missense_Mutation_p.M356V|HNRNPR_uc010odx.1_Missense_Mutation_p.M234V|HNRNPR_uc009vql.2_Missense_Mutation_p.M255V	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	394	RRM 3.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		TTGCCATTCATTTCATCCATA	0.328		NaN											0	0	0	0.004672	0	3	23									
MYOM3	127294	broad.mit.edu	37	1	24383902	24383902	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:24383902G>A	uc001bin.3	-	37	4429	c.4266C>T	c.(4264-4266)ATC>ATT	p.I1422I	MYOM3_uc001bil.3_Silent_p.I315I|MYOM3_uc001bim.3_Silent_p.I1079I	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1422	Ig-like C2-type 4.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TGAACACACTGATGGTGACCT	0.562		NaN											0	0	0	0.013537	0	13	41									
AHDC1	27245	broad.mit.edu	37	1	27874267	27874267	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:27874267G>A	uc009vsy.2	-	6	5329	c.4360C>T	c.(4360-4362)CCC>TCC	p.P1454S	AHDC1_uc009vsz.1_Missense_Mutation_p.P1454S	NM_001029882	NP_001025053	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1454							DNA binding			central_nervous_system(1)	1		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		TCGTAGTGGGGCTGGCCCAGC	0.692		NaN											0	0	0	0.001168	0	5	13									
THRAP3	9967	broad.mit.edu	37	1	36752825	36752825	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:36752825C>T	uc001cae.3	+	4	1218	c.994C>T	c.(994-996)CAG>TAG	p.Q332*	THRAP3_uc001caf.3_Nonsense_Mutation_p.Q332*|THRAP3_uc001cag.1_Nonsense_Mutation_p.Q332*	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	332	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGCTCATCTCAGAAGGAGGA	0.517		NaN	T	USP6	aneurysmal bone cysts								0	0	0	0.00245	0	13	32									
KIAA0754	643314	broad.mit.edu	37	1	39876750	39876750	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:39876750C>T	uc009vvt.1	+	1	1575	c.813C>T	c.(811-813)TTC>TTT	p.F271F	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	135											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGGGAGGCTTCAGTGAGAAGC	0.512		NaN									OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	7	12									
KIAA0467	23334	broad.mit.edu	37	1	43909302	43909302	+	Missense_Mutation	SNP	G	G	A	rs141085666		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:43909302G>A	uc001cjk.1	+	47	6425	c.5963G>A	c.(5962-5964)CGA>CAA	p.R1988Q	KIAA0467_uc001cjl.1_5'Flank	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	2887						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCTGGGAGCCGAGAGGCCCCC	0.602		NaN											0	0	0	0.008871	0	19	68									
KIAA0467	23334	broad.mit.edu	37	1	43913626	43913626	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:43913626G>A	uc001cjk.1	+	53	7312	c.6850G>A	c.(6850-6852)GAG>AAG	p.E2284K	KIAA0467_uc001cjl.1_Missense_Mutation_p.E272K	NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	3183						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGGAGAGGCTGAGCGGCACGT	0.572		NaN											0	0	0	0.004878	0	38	49									
KDM4A	9682	broad.mit.edu	37	1	44169946	44169946	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:44169946G>A	uc001cjx.2	+	22	3266	c.3100G>A	c.(3100-3102)GAG>AAG	p.E1034K	uc001cjy.2_Intron|ST3GAL3_uc009vwu.1_5'Flank|KDM4A_uc010oki.1_3'UTR	NM_014663	NP_055478	O75164	KDM4A_HUMAN	jumonji domain containing 2A	1034					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1						CACAGAGAAAGAGGTTAAGCA	0.443		NaN											0	0	0	0.01441	0	48	93									
PLK3	1263	broad.mit.edu	37	1	45268645	45268645	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:45268645G>A	uc001cmn.2	+	7	868	c.768G>A	c.(766-768)GGG>GGA	p.G256G	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	256	Protein kinase.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					TGCTCTGCGGGAGCCCTCCCT	0.622		NaN											0	0	0	0.010504	0	18	77									
MKNK1	8569	broad.mit.edu	37	1	47024330	47024330	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:47024330G>A	uc001cqb.2	-	14	1559	c.1315C>T	c.(1315-1317)CCC>TCC	p.P439S	MKNK1_uc010omd.1_Missense_Mutation_p.P303S|MKNK1_uc001cqc.2_Missense_Mutation_p.P398S|MKNK1_uc009vyi.2_3'UTR|MKNK1_uc010ome.1_3'UTR	NM_003684	NP_003675	Q9BUB5	MKNK1_HUMAN	MAP kinase-interacting serine/threonine kinase 1	439					intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)					GACTTGCAGGGAGGGGAAAGC	0.622		NaN											0	0	0	0.001984	0	5	37									
PCSK9	255738	broad.mit.edu	37	1	55523773	55523773	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:55523773G>A	uc001cyf.1	+	8	1536	c.1245G>A	c.(1243-1245)CTG>CTA	p.L415L	PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	415	Peptidase S8.				cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GGCAGAGACTGATCCACTTCT	0.617		NaN											0	0	0	0.005443	0	27	41									
USP24	23358	broad.mit.edu	37	1	55566515	55566515	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:55566515C>T	uc001cyg.3	-	41	4788	c.4788G>A	c.(4786-4788)TGG>TGA	p.W1596*		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1756					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						GAAATACCTTCCAAAAATTCT	0.338		NaN											0	0	0	0.001984	0	7	19									
PRKAA2	5563	broad.mit.edu	37	1	57161760	57161760	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:57161760G>A	uc001cyk.3	+	6	787	c.716G>A	c.(715-717)CGT>CAT	p.R239H		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	239	Protein kinase.				carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						TATCTCAATCGTTCTGTCGCC	0.433		NaN											0	0	0	0.01441	0	116	132									
PRKAA2	5563	broad.mit.edu	37	1	57169763	57169763	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:57169763C>T	uc001cyk.3	+	7	979	c.908C>T	c.(907-909)ACA>ATA	p.T303I		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	303					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						TTTGAATGTACAGAATCAGAA	0.383		NaN											0	0	0	0.011902	0	43	61									
C8B	732	broad.mit.edu	37	1	57399040	57399040	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:57399040G>A	uc001cyp.2	-	10	1587	c.1520C>T	c.(1519-1521)CCC>CTC	p.P507L	C8B_uc010oon.1_Missense_Mutation_p.P445L|C8B_uc010ooo.1_Missense_Mutation_p.P455L	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	507	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TCCTTGGCAGGGAGCACAGTG	0.552		NaN											0	0	0	0.00632	0	26	46									
SAMD13	148418	broad.mit.edu	37	1	84791366	84791366	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:84791366A>G	uc001djr.2	+	3	334	c.142A>G	c.(142-144)ATG>GTG	p.M48V	SAMD13_uc010orw.1_Missense_Mutation_p.M34V|SAMD13_uc010orx.1_Missense_Mutation_p.M34V	NM_001010971	NP_001010971	Q5VXD3	SAM13_HUMAN	sterile alpha motif domain containing 13 isoform	54	SAM.										0				all cancers(265;0.00667)|Epithelial(280;0.0219)|OV - Ovarian serous cystadenocarcinoma(397;0.136)		CTGGGCCGTGATGGATGTCGT	0.488		NaN											0	0	0	0.004656	0	27	39									
COL24A1	255631	broad.mit.edu	37	1	86591602	86591602	+	Silent	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:86591602A>C	uc001dlj.2	-	3	459	c.417T>G	c.(415-417)CCT>CCG	p.P139P	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Silent_p.P139P	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	139	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTAATTTTTTAGGTAGTAATT	0.353		NaN											0	0	0	0.00333	0	22	18									
CLCA4	22802	broad.mit.edu	37	1	87029431	87029431	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:87029431C>T	uc009wcs.2	+	4	580	c.536C>T	c.(535-537)TCA>TTA	p.S179L	CLCA4_uc009wct.2_Intron|CLCA4_uc009wcu.2_Intron	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	179						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		CGTGCTAAGTCAAAAAAAATC	0.403		NaN											0	0	0	0.000602	0	5	38									
RBMXL1	494115	broad.mit.edu	37	1	89449393	89449393	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:89449393C>T	uc009wcx.2	-	3	833	c.117G>A	c.(115-117)TTG>TTA	p.L39L	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc001dms.2_Silent_p.L39L	NM_001162536	NP_001156008	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	39	RRM.						nucleotide binding|RNA binding				0						GGTCTTTTATCAAGAGTACTT	0.423		NaN									OREG0013593	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013726	0	34	124									
GBP7	388646	broad.mit.edu	37	1	89615138	89615138	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:89615138G>A	uc001dna.2	-	7	1128	c.989C>T	c.(988-990)GCA>GTA	p.A330V	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	330						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		GTGGTTGGCTGCCCTCTGCAC	0.577		NaN											0	0	0	0.01441	0	48	43									
GBP5	115362	broad.mit.edu	37	1	89734510	89734510	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:89734510G>A	uc001dnc.2	-	4	757	c.220C>T	c.(220-222)CAC>TAC	p.H74Y	GBP5_uc001dnd.2_Missense_Mutation_p.H74Y|GBP5_uc001dne.1_Missense_Mutation_p.H74Y	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	74						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		CCCTTGGTGTGAGACTGCACC	0.488		NaN											0	0	0	0.008871	0	18	46									
CCDC18	343099	broad.mit.edu	37	1	93646363	93646363	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:93646363C>T	uc001dpq.2	+	1	444	c.276C>T	c.(274-276)GTC>GTT	p.V92V	TMED5_uc001dpn.2_5'Flank|TMED5_uc001dpo.2_5'Flank|TMED5_uc001dpp.2_5'Flank	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	Error:Variant_position_missing_in_Q5T9S5_after_alignment										ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		GGGAAAGGGTCAGAGGCTTCC	0.672		NaN											0	0	0	0.001855	0	12	52									
CCDC76	54482	broad.mit.edu	37	1	100598732	100598732	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:100598732C>G	uc001dsv.2	+	1	27	c.8C>G	c.(7-9)ACC>AGC	p.T3S	SASS6_uc001dsu.2_5'Flank|SASS6_uc009wdz.2_5'Flank|CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.T3S	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	3					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		ATTATGGCGACCTCCGCGACG	0.552		NaN											0	0	0	0.003954	0	20	30									
SLC25A24	29957	broad.mit.edu	37	1	108742614	108742614	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:108742614C>T	uc001dvn.3	-	1	361	c.147G>A	c.(145-147)AGG>AGA	p.R49R		NM_013386	NP_037518	Q6NUK1	SCMC1_HUMAN	solute carrier family 25 member 24 isoform 1	49	EF-hand 1.|Mitochondrial intermembrane (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			ovary(1)	1		all_epithelial(167;3.72e-05)|all_lung(203;0.000567)|Lung NSC(277;0.0011)|Melanoma(281;0.211)		Colorectal(144;0.0345)|Lung(183;0.0971)|COAD - Colon adenocarcinoma(174;0.127)|Epithelial(280;0.134)		TGCCCAGGTTCCTGAGCCCCT	0.721		NaN											0	0	0	0.008291	0	8	25									
AKNAD1	254268	broad.mit.edu	37	1	109380186	109380186	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:109380186A>T	uc001dwa.2	-	7	1791	c.1522T>A	c.(1522-1524)TCA>ACA	p.S508T	AKNAD1_uc010ovb.1_Missense_Mutation_p.S215T|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	508										ovary(3)	3						TTTGAGAGTGAAGAGAAGGTG	0.393		NaN											0	0	0	0.000602	0	4	62									
HBXIP	10542	broad.mit.edu	37	1	110950397	110950397	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:110950397G>A	uc001dzr.2	-	1	150	c.92C>T	c.(91-93)TCC>TTC	p.S31F		NM_006402	NP_006393	O43504	HBXIP_HUMAN	hepatitis B virus x-interacting protein	Error:Variant_position_missing_in_O43504_after_alignment					anti-apoptosis|negative regulation of caspase activity|response to virus|viral genome replication	cytosol	protein binding			large_intestine(1)|ovary(1)|pancreas(1)	3		all_cancers(81;4.08e-06)|all_epithelial(167;4.38e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0237)|all cancers(265;0.0675)|Epithelial(280;0.0732)|Colorectal(144;0.102)|LUSC - Lung squamous cell carcinoma(189;0.134)		TTCTTTACTGGAAAACATCAC	0.622		NaN											0	0	0	0.008291	0	11	26									
WDR77	79084	broad.mit.edu	37	1	111989760	111989760	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:111989760C>T	uc001ebb.2	-	4	489	c.450G>A	c.(448-450)AAG>AAA	p.K150K	WDR77_uc010owd.1_RNA|WDR77_uc010owe.1_Intron|ATP5F1_uc009wgf.1_5'Flank|ATP5F1_uc001ebc.2_5'Flank|ATP5F1_uc001ebd.3_5'Flank	NM_024102	NP_077007	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	150	WD 2.				ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding				0		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGTCCCAAACCTTGATGCTAA	0.398		NaN											0	0	0	0.00874	0	39	43									
C1orf183	55924	broad.mit.edu	37	1	112281828	112281828	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:112281828G>A	uc001ebo.1	-	1	195	c.37C>T	c.(37-39)CGT>TGT	p.R13C	C1orf183_uc001ebp.1_Intron|uc001ebq.1_5'Flank	NM_019099	NP_061972	Q9NTI7	CA183_HUMAN	hypothetical protein LOC55924 isoform 1	13										ovary(2)	2		all_cancers(81;7.29e-06)|all_epithelial(167;4.98e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.16e-05)		Lung(183;0.0155)|Colorectal(144;0.0289)|all cancers(265;0.0592)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0852)|COAD - Colon adenocarcinoma(174;0.113)		TTGAGGCGACGGAGATAGCAG	0.672		NaN											0	0	0	0.008291	0	10	21									
LRIG2	9860	broad.mit.edu	37	1	113638961	113638961	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:113638961T>C	uc001edf.1	+	8	1263	c.1065T>C	c.(1063-1065)TTT>TTC	p.F355F	LRIG2_uc009wgn.1_Silent_p.F252F	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	355	LRR 12.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		ATGGTGTATTTAGATTTCTTT	0.353		NaN											0	0	0	0.003755	0	32	51									
NHLH2	4808	broad.mit.edu	37	1	116380930	116380930	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:116380930C>G	uc009wgz.2	-	2	569	c.64G>C	c.(64-66)GAG>CAG	p.E22Q	NHLH2_uc001efy.2_Missense_Mutation_p.E22Q	NM_001111061	NP_001104531	Q02577	HEN2_HUMAN	nescient helix loop helix 2	22					cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0	Lung SC(450;0.184)	all_cancers(81;1.75e-06)|all_epithelial(167;1.16e-06)|all_lung(203;9.55e-06)|Lung NSC(69;5.83e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CCCAGGGACTCCGGATCCGAG	0.657		NaN											0	0	0	0.009096	0	4	11									
CD101	9398	broad.mit.edu	37	1	117556087	117556087	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:117556087G>A	uc010oxb.1	+	4	959	c.901G>A	c.(901-903)GAA>AAA	p.E301K	CD101_uc009whd.2_Missense_Mutation_p.E301K|CD101_uc010oxc.1_Missense_Mutation_p.E301K|CD101_uc010oxd.1_Missense_Mutation_p.E239K	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	301	Ig-like C2-type 3.|Extracellular (Potential).				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GAAACCCTTAGAACTGGTTTG	0.463		NaN											0	0	0	0.003163	0	15	94									
TTF2	8458	broad.mit.edu	37	1	117629135	117629135	+	Silent	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:117629135C>G	uc001egy.2	+	12	2171	c.2151C>G	c.(2149-2151)CTC>CTG	p.L717L		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	717	Helicase ATP-binding.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		GTGCAAACCTCAATGTGGAGG	0.537		NaN											0	0	0	0.004482	0	8	13									
SF3B4	10262	broad.mit.edu	37	1	149897916	149897916	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:149897916G>A	uc001etj.1	-	4	776	c.725C>T	c.(724-726)TCC>TTC	p.S242F	SF3B4_uc001eti.1_Missense_Mutation_p.S6F|SF3B4_uc001etk.1_Missense_Mutation_p.S242F|SF3B4_uc009wll.1_Missense_Mutation_p.S242F	NM_005850	NP_005841	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4	242						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			GGGTGGGAAGGAGCCAGGAGG	0.582		NaN											0	0	0	0.00499	0	15	24									
FAM63A	55793	broad.mit.edu	37	1	150972380	150972380	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:150972380T>C	uc001ewf.2	-	7	2480	c.796A>G	c.(796-798)ATC>GTC	p.I266V	FAM63A_uc001ewc.2_Missense_Mutation_p.I124V|FAM63A_uc010pcm.1_Missense_Mutation_p.I171V|FAM63A_uc001ewd.2_Missense_Mutation_p.I124V|FAM63A_uc001ewe.2_Missense_Mutation_p.I100V|FAM63A_uc010pcn.1_Missense_Mutation_p.I314V|FAM63A_uc001ewg.2_Missense_Mutation_p.I266V	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	266							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTGCAGGTGATGATCCTCTCC	0.488		NaN											0	0	0	0.010504	0	20	59									
TDRD10	126668	broad.mit.edu	37	1	154493838	154493838	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:154493838A>G	uc009wow.2	+	6	1090	c.252A>G	c.(250-252)ACA>ACG	p.T84T	TDRD10_uc001ffd.2_Silent_p.T84T|TDRD10_uc001ffe.2_Silent_p.T5T	NM_001098475	NP_001091945	Q5VZ19	TDR10_HUMAN	tudor domain containing 10 isoform a	84	RRM.						nucleotide binding|RNA binding			ovary(1)	1	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGAAAGTGACACTTGCAATCC	0.498		NaN											0	0	0	0.01441	0	48	127									
FLAD1	80308	broad.mit.edu	37	1	154962650	154962650	+	Silent	SNP	T	T	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:154962650T>A	uc001fgf.1	+	4	1635	c.1281T>A	c.(1279-1281)GTT>GTA	p.V427V	FLAD1_uc001fgd.1_Silent_p.V427V|FLAD1_uc001fge.1_Silent_p.V330V|FLAD1_uc001fgg.1_Silent_p.V330V|FLAD1_uc001fgh.1_Missense_Mutation_p.F111Y	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	427	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TACCTGATGTTCCAAACCCCC	0.468		NaN											0	0	0	0.01441	0	106	209									
KIRREL	55243	broad.mit.edu	37	1	158064160	158064161	+	Missense_Mutation	DNP	CG	CG	AA	rs148421111		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:158064160_158064161CG>AA	uc001frn.3	+	14	2181_2182	c.1777_1778CG>AA	c.(1777-1779)CGG>AAG	p.R593K	KIRREL_uc010pib.1_Missense_Mutation_p.R493K|KIRREL_uc009wsq.2_Missense_Mutation_p.R429K|KIRREL_uc001fro.3_Missense_Mutation_p.R407K|uc001frp.2_5'Flank	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	593	Cytoplasmic (Potential).			DTREEYEMKDPTNGY -> ERPRIRGRLNTSYSD (in Ref. 1).		integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					CATCGACACCCGGGAGGAGTAT	0.614		NaN											0	0	0	0.004672	0	4	19									
OR10K1	391109	broad.mit.edu	37	1	158435526	158435526	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:158435526A>T	uc010pij.1	+	1	175	c.175A>T	c.(175-177)ATG>TTG	p.M59L		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCATACTCCCATGTACTTCTT	0.473		NaN											0	0	0	0.013114	0	43	131									
FCRLB	127943	broad.mit.edu	37	1	161696644	161696644	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:161696644G>A	uc001gbh.2	+	7	960	c.726G>A	c.(724-726)GCG>GCA	p.A242A	FCRLB_uc009wus.2_Silent_p.A242A|FCRLB_uc001gbj.2_Missense_Mutation_p.R194Q|FCRLB_uc001gbk.2_Missense_Mutation_p.G208S|FCRLB_uc001gbl.2_Missense_Mutation_p.R187Q|FCRLB_uc001gbm.2_Missense_Mutation_p.G201S|FCRLB_uc001gbi.2_Silent_p.A242A|FCRLB_uc001gbn.3_Missense_Mutation_p.G245S	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	242						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			ACAGCCGCGCGGTGCGCCGCT	0.706		NaN											0	0	0	0.000602	0	4	5									
ILDR2	387597	broad.mit.edu	37	1	166926077	166926077	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:166926077T>G	uc001gdx.1	-	3	448	c.392A>C	c.(391-393)CAA>CCA	p.Q131P		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	131	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1						CTTTCCAATTTGAAGATCTGC	0.403		NaN											0	0	0	0.004482	0	8	44									
DNM3	26052	broad.mit.edu	37	1	172357752	172357752	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:172357752A>G	uc001gie.2	+	20	2501	c.2325A>G	c.(2323-2325)ACA>ACG	p.T775T	DNM3_uc001gif.2_Silent_p.T771T|DNM3_uc001gih.1_Silent_p.T131T	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	781					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						GGAGGCCAACACTAAGTGCTC	0.562		NaN											0	0	0	0.00499	0	15	45									
TDRD5	163589	broad.mit.edu	37	1	179621324	179621324	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:179621324C>T	uc001gnf.1	+	13	2402	c.2152C>T	c.(2152-2154)CGT>TGT	p.R718C	TDRD5_uc010pnp.1_Missense_Mutation_p.R718C|TDRD5_uc001gnh.1_Missense_Mutation_p.R273C	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	718					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						GAGTGAGTTACGTATCTTGGT	0.289		NaN											0	0	0	0.013537	0	12	25									
RNF2	6045	broad.mit.edu	37	1	185056735	185056735	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:185056735G>A	uc001grc.1	+	2	283	c.50G>A	c.(49-51)TGG>TAG	p.W17*	RNF2_uc001grd.1_Nonsense_Mutation_p.W17*	NM_007212	NP_009143	Q99496	RING2_HUMAN	ring finger protein 2	17	Interaction with HIP2.				histone H2A monoubiquitination|transcription, DNA-dependent	MLL1 complex|PcG protein complex|ubiquitin ligase complex	RING-like zinc finger domain binding|zinc ion binding			breast(1)	1		Breast(1374;0.000496)		Colorectal(1306;6.9e-08)|KIRC - Kidney renal clear cell carcinoma(1967;8.12e-06)		AGCAAAACATGGGAACTCAGT	0.388		NaN											0	0	0	0.010818	0	26	66									
IVNS1ABP	10625	broad.mit.edu	37	1	185276256	185276256	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:185276256C>T	uc001grl.2	-	7	1170	c.547G>A	c.(547-549)GAA>AAA	p.E183K	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	183	Sufficient for AHR interaction and signaling.|BACK.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						ACATTATCTTCAAGCATTACC	0.413		NaN											0	0	0	0.00245	0	14	29									
HMCN1	83872	broad.mit.edu	37	1	185704134	185704134	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:185704134A>G	uc001grq.1	+	1	452	c.223A>G	c.(223-225)AAA>GAA	p.K75E		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	75	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAAAAGACCTAAAAGACCTCT	0.368		NaN											0	0	0	0.00632	0	26	44									
KCNT2	343450	broad.mit.edu	37	1	196342326	196342326	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:196342326A>G	uc001gtd.1	-	14	1407	c.1347T>C	c.(1345-1347)TGT>TGC	p.C449C	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.C449C|KCNT2_uc001gtf.1_Silent_p.C449C|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.C449C|KCNT2_uc009wyv.1_Silent_p.C424C	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	449	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CTGGGCATATACAGTTTAAAG	0.294		NaN											0	0	0	0.003954	0	22	45									
ASPM	259266	broad.mit.edu	37	1	197111797	197111797	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:197111797C>G	uc001gtu.2	-	3	1842	c.1585G>C	c.(1585-1587)GAA>CAA	p.E529Q	ASPM_uc001gtv.2_Missense_Mutation_p.E529Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	529					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ATTACTTTTTCATGTTCACCC	0.313		NaN											0	0	0	0.009535	0	31	95									
NR5A2	2494	broad.mit.edu	37	1	200014630	200014630	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:200014630C>T	uc001gvb.2	+	4	587	c.381C>T	c.(379-381)AAC>AAT	p.N127N	NR5A2_uc001gvc.2_Silent_p.N81N|NR5A2_uc009wzh.2_Silent_p.N87N|NR5A2_uc010pph.1_Silent_p.N55N	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	127	Nuclear receptor.|NR C4-type.				embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					AAAACCAGAACTGCCAAATTG	0.328		NaN											0	0	0	0.001855	0	14	29									
PPP1R15B	84919	broad.mit.edu	37	1	204379892	204379892	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:204379892G>A	uc001hav.3	-	1	1053	c.648C>T	c.(646-648)TTC>TTT	p.F216F		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	216					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			ATACCACACTGAAATTGTCTA	0.498		NaN											0	0	0	0.00874	0	42	93									
DSTYK	25778	broad.mit.edu	37	1	205180623	205180623	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:205180623G>A	uc001hbw.2	-	1	105	c.41C>T	c.(40-42)TCG>TTG	p.S14L	DSTYK_uc001hbx.2_Missense_Mutation_p.S14L	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	14						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						GCCGGGACCCGAGACGGGCTC	0.756		NaN											0	0	0	0.009096	0	4	5									
SLC45A3	85414	broad.mit.edu	37	1	205633626	205633626	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:205633626C>T	uc001hda.1	-	2	498	c.159G>A	c.(157-159)ATG>ATA	p.M53I	SLC45A3_uc010prn.1_5'Flank|SLC45A3_uc010pro.1_5'Flank|SLC45A3_uc010prp.1_RNA|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	53	Helical; Name=2; (Potential).				transmembrane transport	integral to membrane			SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			GCACCATGGTCATGAACTTCT	0.572		NaN	T	ETV1|ETV5|ELK4|ERG	prostate 								0	0	0	0.01441	0	71	166									
PLXNA2	5362	broad.mit.edu	37	1	208390236	208390236	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:208390236C>T	uc001hgz.2	-	2	1790	c.1032G>A	c.(1030-1032)AAG>AAA	p.K344K	PLXNA2_uc001hha.3_Silent_p.K398K	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	344	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GGTGATACTGCTTCTGCCCTT	0.592		NaN											0	0	0	0.008871	0	20	30									
RPS6KC1	26750	broad.mit.edu	37	1	213415584	213415584	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:213415584G>A	uc010ptr.1	+	11	2924	c.2765G>A	c.(2764-2766)AGA>AAA	p.R922K	RPS6KC1_uc001hkd.2_Missense_Mutation_p.R910K|RPS6KC1_uc010pts.1_Missense_Mutation_p.R710K|RPS6KC1_uc010ptt.1_Missense_Mutation_p.R710K|RPS6KC1_uc010ptu.1_Missense_Mutation_p.R741K|RPS6KC1_uc010ptv.1_Missense_Mutation_p.R457K|RPS6KC1_uc001hke.2_Missense_Mutation_p.R741K	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	922	Protein kinase 2.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		GCTTTACATAGAGAGGGAATT	0.418		NaN											0	0	0	0.00623	0	35	69									
USH2A	7399	broad.mit.edu	37	1	216591900	216591900	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:216591900G>A	uc001hku.1	-	3	994	c.607C>T	c.(607-609)CTG>TTG	p.L203L	USH2A_uc001hkv.2_Silent_p.L203L	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	203	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTCTCCCCAGTGTCATTACT	0.338		NaN								HNSCC(13;0.011)			0	0	0	0.004656	0	24	66									
TP53BP2	7159	broad.mit.edu	37	1	223986194	223986194	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:223986194C>T	uc010pvb.1	-	12	1963	c.1671G>A	c.(1669-1671)CCG>CCA	p.P557P	TP53BP2_uc001hod.2_Silent_p.P428P|TP53BP2_uc010puz.1_Intron|TP53BP2_uc010pva.1_Silent_p.P196P	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	551					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		GCAGCACTCTCGGCTGCTGCC	0.542		NaN											0	0	0	0.01441	0	47	116									
ACBD3	64746	broad.mit.edu	37	1	226340098	226340098	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:226340098G>A	uc001hpy.2	-	7	1360	c.1313C>T	c.(1312-1314)TCT>TTT	p.S438F		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	438	GOLD.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		AGTGTTTGGAGAGTCTGTCCA	0.478		NaN											0	0	0	0.01441	0	67	110									
OBSCN	84033	broad.mit.edu	37	1	228467915	228467915	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:228467915G>A	uc009xez.1	+	29	7743	c.7699G>A	c.(7699-7701)GCA>ACA	p.A2567T	OBSCN_uc001hsn.2_Missense_Mutation_p.A2567T|OBSCN_uc001hsp.1_Missense_Mutation_p.A266T|OBSCN_uc001hsq.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2567	Ig-like 25.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCTACAGGATGCAGAGGCCAC	0.632		NaN											0	0	0	0.013537	0	11	60									
NUP133	55746	broad.mit.edu	37	1	229625722	229625722	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:229625722G>A	uc001htn.2	-	9	1266	c.1174C>T	c.(1174-1176)CAA>TAA	p.Q392*		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	392					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				GGATTATATTGAGTGACTTCT	0.318		NaN											0	0	0	0.010504	0	16	23									
AGT	183	broad.mit.edu	37	1	230839024	230839024	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:230839024C>T	uc001hty.3	-	5	1829	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	AGT_uc009xfe.2_3'UTR|AGT_uc009xff.2_Missense_Mutation_p.E413K	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	441					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	TGGGTAGACTCTGTGGGCTCT	0.527		NaN											0	0	0	0.013726	0	32	71									
TTC13	79573	broad.mit.edu	37	1	231048454	231048454	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:231048454G>A	uc001huf.3	-	19	2175	c.2144C>T	c.(2143-2145)ACA>ATA	p.T715I	TTC13_uc009xfi.2_Missense_Mutation_p.T662I|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.T661I|TTC13_uc009xfk.1_Missense_Mutation_p.T604I	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	715							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		ATATAATTGTGTCCTTTCTTC	0.318		NaN											0	0	0	0.008871	0	19	125									
TTC13	79573	broad.mit.edu	37	1	231069546	231069546	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:231069546T>G	uc001huf.3	-	9	993	c.962A>C	c.(961-963)AAA>ACA	p.K321T	TTC13_uc009xfi.2_Missense_Mutation_p.K268T|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.K268T|TTC13_uc009xfk.1_Missense_Mutation_p.K211T	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	321	TPR 5.						binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CCCTAGACTTTTATATGCATC	0.343		NaN											0	0	0	0.013726	0	27	72									
SIPA1L2	57568	broad.mit.edu	37	1	232551310	232551310	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:232551310C>T	uc001hvg.2	-	17	4850	c.4692G>A	c.(4690-4692)CTG>CTA	p.L1564L	SIPA1L2_uc001hvf.2_Silent_p.L638L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1564					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GGAGGGGCATCAGGCCAGGAT	0.537		NaN											0	0	0	0.01441	0	41	92									
ARID4B	51742	broad.mit.edu	37	1	235338568	235338568	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:235338568C>T	uc001hwq.2	-	22	4093	c.3595G>A	c.(3595-3597)GAT>AAT	p.D1199N	ARID4B_uc001hwr.2_Missense_Mutation_p.D1113N|ARID4B_uc001hwp.2_RNA	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	1199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GGATCCTTATCACCATTCTTT	0.408		NaN											0	0	0	0.005443	0	27	64									
ARID4B	51742	broad.mit.edu	37	1	235338665	235338665	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:235338665C>G	uc001hwq.2	-	22	3996	c.3498G>C	c.(3496-3498)AAG>AAC	p.K1166N	ARID4B_uc001hwr.2_Missense_Mutation_p.K1080N|ARID4B_uc001hwp.2_RNA	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	1166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			CTGGCTGACTCTTAGTTATAC	0.358		NaN											0	0	0	0.005443	0	26	57									
OR2M3	127062	broad.mit.edu	37	1	248367166	248367166	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:248367166G>T	uc010pzg.1	+	1	797	c.797G>T	c.(796-798)CGC>CTC	p.R266L		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACATCTGATCGCTCCCCAACA	0.502		NaN											1	0	3.74213e-36	0.01441	4.06774e-36	58	110									
DIP2C	22982	broad.mit.edu	37	10	486827	486827	+	Silent	SNP	G	G	A	rs139321678	byFrequency	TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:486827G>A	uc001ifp.2	-	4	468	c.378C>T	c.(376-378)GAC>GAT	p.D126D	DIP2C_uc009xhk.1_Missense_Mutation_p.T128M	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	126						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGTGTAGGCGTCCATCGAGG	0.607		NaN											0	0	0	0.006122	0	15	45									
IDI2	91734	broad.mit.edu	37	10	1066834	1066834	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:1066834T>C	uc001ifv.1	-	4	304	c.239A>G	c.(238-240)TAT>TGT	p.Y80C	C10orf110_uc010qaf.1_5'Flank|C10orf110_uc001ifx.3_5'Flank|C10orf110_uc001ifw.3_5'Flank|C10orf110_uc001ify.3_5'Flank	NM_033261	NP_150286	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	80	Nudix hydrolase.				carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding				0		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		GTCGGTAAAATACCCTGGAAA	0.443		NaN											0	0	0	0.008871	0	16	27									
FRMD4A	55691	broad.mit.edu	37	10	13782239	13782239	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:13782239G>A	uc001ims.2	-	11	979	c.627C>T	c.(625-627)ATC>ATT	p.I209I	FRMD4A_uc009xjf.1_Silent_p.I209I|FRMD4A_uc001imt.1_Silent_p.I242I|FRMD4A_uc001imu.1_Silent_p.I225I	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	209	FERM.					cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GAGACTCCACGATGCTCATGT	0.423		NaN											0	0	0	0.00499	0	17	56									
PLXDC2	84898	broad.mit.edu	37	10	20453444	20453444	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:20453444A>T	uc001iqg.1	+	7	1468	c.831A>T	c.(829-831)AAA>AAT	p.K277N	PLXDC2_uc001iqh.1_Missense_Mutation_p.K228N|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	277	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						ATCCAGTGAAAGTCGGACTGT	0.443		NaN											0	0	0	0.009096	0	4	43									
ABI1	10006	broad.mit.edu	37	10	27149698	27149698	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:27149698T>C	uc001isx.2	-	1	262	c.95A>G	c.(94-96)TAC>TGC	p.Y32C	ABI1_uc001ite.2_Missense_Mutation_p.Y32C|ABI1_uc010qdh.1_Missense_Mutation_p.Y32C|ABI1_uc010qdi.1_Missense_Mutation_p.Y32C|ABI1_uc001isy.2_Missense_Mutation_p.Y32C|ABI1_uc001ita.2_Missense_Mutation_p.Y32C|ABI1_uc001isz.2_Missense_Mutation_p.Y32C|ABI1_uc001itb.2_Missense_Mutation_p.Y32C|ABI1_uc001itc.2_Missense_Mutation_p.Y32C|ABI1_uc010qdj.1_Missense_Mutation_p.Y32C|ABI1_uc001itd.2_Missense_Mutation_p.Y32C|ABI1_uc010qdk.1_Missense_Mutation_p.Y32C	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	32	Required for binding to WASF1 (By similarity).				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						GTTTTCACAGTAGTCTGCCAC	0.627		NaN											0	0	0	0.003954	0	24	62									
RAB18	22931	broad.mit.edu	37	10	27793340	27793340	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:27793340C>T	uc001itv.2	+	1	92	c.42C>T	c.(40-42)ATC>ATT	p.I14I	RAB18_uc001itw.2_Silent_p.I14I|RAB18_uc010qdq.1_Silent_p.I14I|RAB18_uc010qdr.1_Silent_p.I14I	NM_021252	NP_067075	Q9NP72	RAB18_HUMAN	RAB18, member RAS oncogene family	14					endocytosis|protein transport|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|GTPase activity|transcription factor binding				0						TCCTCATCATCGGCGAGAGTG	0.682		NaN											0	0	0	0.00308	0	5	10									
RBP3	5949	broad.mit.edu	37	10	48389779	48389779	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:48389779C>T	uc001jez.2	-	1	1213	c.1099G>A	c.(1099-1101)GAT>AAT	p.D367N		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	367	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GTGACCAGATCTTCCTCGGAG	0.632		NaN											0	0	0	0.001855	0	14	33									
RBP3	5949	broad.mit.edu	37	10	48389782	48389782	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:48389782C>T	uc001jez.2	-	1	1210	c.1096G>A	c.(1096-1098)GAA>AAA	p.E366K		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	366	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	ACCAGATCTTCCTCGGAGACC	0.627		NaN											0	0	0	0.00245	0	15	31									
RHOBTB1	9886	broad.mit.edu	37	10	62631954	62631954	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:62631954G>A	uc001jli.2	-	11	2348	c.1910C>T	c.(1909-1911)TCA>TTA	p.S637L	RHOBTB1_uc001jlh.2_Missense_Mutation_p.S637L|RHOBTB1_uc001jlj.2_Missense_Mutation_p.S637L|RHOBTB1_uc001jlk.2_Missense_Mutation_p.S637L|RHOBTB1_uc009xpe.1_Missense_Mutation_p.S575L|RHOBTB1_uc009xpd.2_Intron|RHOBTB1_uc001jll.2_Missense_Mutation_p.S387L	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	637					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					TGCAGATTTTGATTTGATTTC	0.493		NaN											0	0	0	0.014323	0	23	72									
VPS26A	9559	broad.mit.edu	37	10	70930917	70930917	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:70930917A>G	uc001jpb.2	+	9	1002	c.876A>G	c.(874-876)ATA>ATG	p.I292M	VPS26A_uc001jpc.2_Missense_Mutation_p.N245D|VPS26A_uc009xqa.2_Missense_Mutation_p.I285M|VPS26A_uc001jpd.2_Missense_Mutation_p.I181M	NM_004896	NP_004887	O75436	VP26A_HUMAN	vacuolar protein sorting 26 A isoform 1	292					retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity				0						ACTAGGAGATAATTTTATGGA	0.338		NaN											0	0	0	0.014323	0	23	64									
SUPV3L1	6832	broad.mit.edu	37	10	70940254	70940254	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:70940254G>A	uc001jpe.1	+	1	262	c.207G>A	c.(205-207)GTG>GTA	p.V69V	SUPV3L1_uc010qjd.1_5'UTR	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	69					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						CCCTGACTGTGAAACCTCAGG	0.647		NaN											0	0	0	0.00278	0	21	95									
SUPV3L1	6832	broad.mit.edu	37	10	70967593	70967593	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:70967593G>T	uc001jpe.1	+	14	1876	c.1821G>T	c.(1819-1821)TGG>TGT	p.W607C	SUPV3L1_uc010qjd.1_Missense_Mutation_p.W476C	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	607					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						CCTTTGCATGGTTACGCCGAT	0.443		NaN											1	0	0.00829132	0.008291	0.00853897	9	40									
FUT11	170384	broad.mit.edu	37	10	75533107	75533107	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:75533107A>T	uc001jva.2	+	2	911	c.868A>T	c.(868-870)ACA>TCA	p.T290S	FUT11_uc001juy.1_Nonstop_Mutation_p.*288C|FUT11_uc001juz.1_Missense_Mutation_p.T290S	NM_173540	NP_775811	Q495W5	FUT11_HUMAN	fucosyltransferase 11 (alpha (1,3)	290	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	Prostate(51;0.0112)					CGACTACATGACAGAAAAACT	0.567		NaN											0	0	0	0.004656	0	25	48									
KIAA0913	23053	broad.mit.edu	37	10	75556602	75556602	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:75556602C>T	uc009xrl.2	+	16	3121	c.3089C>T	c.(3088-3090)TCT>TTT	p.S1030F	KIAA0913_uc001jve.2_Missense_Mutation_p.S1035F|KIAA0913_uc001jvf.2_Missense_Mutation_p.S1030F|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.S465F|KIAA0913_uc010qkr.1_Missense_Mutation_p.S453F|KIAA0913_uc001jvj.2_Missense_Mutation_p.S453F|KIAA0913_uc009xrn.1_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	1030							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					TTCTACTCATCTAGCCGCCCA	0.577		NaN											0	0	0	0.00245	0	14	72									
TNKS2	80351	broad.mit.edu	37	10	93605573	93605573	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:93605573C>G	uc001khp.2	+	18	2531	c.2234C>G	c.(2233-2235)GCT>GGT	p.A745G		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	745	ANK 15.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				GACAAATGGGCTTTCACACCT	0.433		NaN											0	0	0	0.001168	0	6	46									
BTAF1	9044	broad.mit.edu	37	10	93768614	93768614	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:93768614A>G	uc001khr.2	+	27	3940	c.3842A>G	c.(3841-3843)AAT>AGT	p.N1281S		NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	1281	Helicase ATP-binding.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				GCATTTCTTAATAAGTATAAA	0.294		NaN											0	0	0	0.001855	0	9	42									
EXOC6	54536	broad.mit.edu	37	10	94757304	94757304	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:94757304A>G	uc001kig.2	+	19	2093	c.2027A>G	c.(2026-2028)GAC>GGC	p.D676G	EXOC6_uc010qnr.1_Missense_Mutation_p.D692G|EXOC6_uc001kie.2_Missense_Mutation_p.D671G|EXOC6_uc009xub.2_Missense_Mutation_p.D675G|EXOC6_uc009xuc.2_Missense_Mutation_p.D573G|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Missense_Mutation_p.D250G	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	676					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				ATGCTACTGGACAGTGAGTTA	0.353		NaN											0	0	0	0.001984	0	7	41									
MYOF	26509	broad.mit.edu	37	10	95113570	95113570	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:95113570G>A	uc001kin.2	-	32	3602	c.3479C>T	c.(3478-3480)TCA>TTA	p.S1160L	MYOF_uc001kio.2_Missense_Mutation_p.S1147L|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	1160	Cytoplasmic (Potential).|C2 4.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						TCCTTTACCTGAAAAGCTATC	0.353		NaN											0	0	0	0.005443	0	24	77									
DNTT	1791	broad.mit.edu	37	10	98079103	98079103	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:98079103T>C	uc001kmf.2	+	3	633	c.463T>C	c.(463-465)TGT>CGT	p.C155R	DNTT_uc001kmg.2_Missense_Mutation_p.C155R	NM_004088	NP_004079	P04053	TDT_HUMAN	terminal deoxynucleotidyltransferase isoform 1	155	Mediates interaction with DNTTIP2.				DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			ovary(1)	1		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		CCAGTATGCGTGTCAGAGAAG	0.458		NaN											0	0	0	0.003271	0	31	120									
SEC31B	25956	broad.mit.edu	37	10	102256971	102256971	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:102256971T>C	uc001krc.1	-	17	2159	c.2057A>G	c.(2056-2058)TAT>TGT	p.Y686C	SEC31B_uc010qpo.1_Missense_Mutation_p.Y685C|SEC31B_uc001krd.1_Missense_Mutation_p.Y223C|SEC31B_uc001krf.1_Missense_Mutation_p.Y223C|SEC31B_uc001kre.1_Missense_Mutation_p.Y223C|SEC31B_uc001krg.1_Missense_Mutation_p.Y255C	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	686	WD 7.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TGAGCACACATAACAGAGTCT	0.567		NaN											0	0	0	0.007413	0	14	53									
LDB1	8861	broad.mit.edu	37	10	103868023	103868023	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:103868023C>T	uc009xwz.2	-	11	1406	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K	LDB1_uc001kuk.3_Missense_Mutation_p.E319K	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	355	LIM-binding domain (LID) (By similarity).				histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		ATGAGCCTCTCGTCCTCGTCC	0.622		NaN											0	0	0	0.001855	0	12	45									
COL17A1	1308	broad.mit.edu	37	10	105802183	105802183	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:105802183T>C	uc001kxr.2	-	36	2715	c.2546A>G	c.(2545-2547)CAT>CGT	p.H849R		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	849	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CATACCTTGATGTCCTGGGAG	0.537		NaN											0	0	0	0.006214	0	8	40									
PDCD4	27250	broad.mit.edu	37	10	112641080	112641080	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:112641080A>G	uc001kzh.2	+	3	376	c.133A>G	c.(133-135)ATT>GTT	p.I45V	PDCD4_uc001kzg.2_Missense_Mutation_p.I34V|PDCD4_uc010qre.1_Missense_Mutation_p.I31V	NM_014456	NP_055271	Q53EL6	PDCD4_HUMAN	programmed cell death 4 isoform 1	45					apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			ovary(1)|breast(1)|skin(1)	3		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TGGAAATTGGATTTCAGCATC	0.413		NaN											0	0	0	0.00278	0	23	88									
SHOC2	8036	broad.mit.edu	37	10	112771502	112771502	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:112771502C>G	uc001kzl.3	+	9	2024	c.1675C>G	c.(1675-1677)CAG>GAG	p.Q559E	SHOC2_uc009xxx.2_Missense_Mutation_p.Q559E|SHOC2_uc010qrg.1_Missense_Mutation_p.Q198E|SHOC2_uc001kzn.2_Missense_Mutation_p.Q513E	NM_007373	NP_031399	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog	559	LRR 20.				fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			ovary(1)|skin(1)	2				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		CCTTCCACCTCAGATTGTTGC	0.488		NaN											0	0	0	0.005524	0	36	58									
RAB11FIP2	22841	broad.mit.edu	37	10	119799820	119799820	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:119799820C>T	uc001ldj.1	-	2	1050	c.610G>A	c.(610-612)GAA>AAA	p.E204K	RAB11FIP2_uc009xyz.1_Missense_Mutation_p.E204K	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	204					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		ATCTGTATTTCACCACTTGAA	0.413		NaN											0	0	0	0.003271	0	35	52									
EIF3A	8661	broad.mit.edu	37	10	120802040	120802040	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:120802040G>A	uc001ldu.2	-	19	3138	c.2992C>T	c.(2992-2994)CCC>TCC	p.P998S	EIF3A_uc010qsu.1_Missense_Mutation_p.P964S|EIF3A_uc009xzg.1_Missense_Mutation_p.P37S	NM_003750	NP_003741	Q14152	EIF3A_HUMAN	eukaryotic translation initiation factor 3,	998	Asp-rich.|8.|25 X 10 AA approximate tandem repeats of [DE]-[DE]-[DE]-R-[SEVGFPILV]-[HPSN]- [RSW]-[RL]-[DRGTIHN]-[EPMANLGDT].				formation of translation initiation complex	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|structural molecule activity|translation initiation factor activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0236)		ATTCGTCTGGGAGGCCTGTCA	0.572		NaN											0	0	0	0.01441	0	61	94									
SEC23IP	11196	broad.mit.edu	37	10	121652347	121652347	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:121652347C>T	uc001leu.1	+	1	125	c.53C>T	c.(52-54)TCG>TTG	p.S18L	SEC23IP_uc010qtc.1_5'UTR	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	18	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		ACTTCCTCATCGGGCACTAAC	0.627		NaN											0	0	0	0.00308	0	8	25									
SEC23IP	11196	broad.mit.edu	37	10	121671610	121671610	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:121671610G>A	uc001leu.1	+	6	1318	c.1246G>A	c.(1246-1248)GAT>AAT	p.D416N	SEC23IP_uc010qtc.1_Missense_Mutation_p.D205N	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	416					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CACCACGCAAGATGGACAGAC	0.433		NaN											0	0	0	0.00874	0	42	63									
FGFR2	2263	broad.mit.edu	37	10	123258016	123258016	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:123258016T>C	uc010qtk.1	-	13	2312	c.1665A>G	c.(1663-1665)ACA>ACG	p.T555T	FGFR2_uc010qtg.1_Silent_p.T443T|FGFR2_uc010qth.1_Silent_p.T440T|FGFR2_uc010qti.1_Silent_p.T466T|FGFR2_uc010qtj.1_Silent_p.T556T|FGFR2_uc010qtl.1_Silent_p.T439T|FGFR2_uc010qtm.1_Silent_p.T438T|FGFR2_uc001lfl.3_Silent_p.T556T|FGFR2_uc001lfm.2_Silent_p.T467T|FGFR2_uc001lfg.3_Silent_p.T163T	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	555	Cytoplasmic (Potential).|Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CACCATCCTGTGTGCAGGCTC	0.438		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.000602	0	5	43									
TACC2	10579	broad.mit.edu	37	10	123845111	123845111	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:123845111G>A	uc001lfv.2	+	4	3456	c.3096G>A	c.(3094-3096)AAG>AAA	p.K1032K	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Silent_p.K1032K|TACC2_uc010qtv.1_Silent_p.K1032K	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1032						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCTTGAGTAAGAGGGAGATGG	0.582		NaN											0	0	0	0.001984	0	7	47									
FAM53B	9679	broad.mit.edu	37	10	126370704	126370704	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:126370704G>A	uc001lhv.1	-	4	901	c.378C>T	c.(376-378)TGC>TGT	p.C126C	FAM53B_uc001lhu.1_Silent_p.C126C|FAM53B_uc001lhw.2_Silent_p.C126C	NM_014661	NP_055476	Q14153	FA53B_HUMAN	hypothetical protein LOC9679	126										ovary(1)|pancreas(1)	2		all_lung(145;0.0191)|Lung NSC(174;0.0301)|Colorectal(57;0.106)|all_neural(114;0.117)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.15)		ATGATGTCCGGCAACTGGACA	0.602		NaN											0	0	0	0.004672	0	3	17									
JAKMIP3	282973	broad.mit.edu	37	10	133949530	133949530	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:133949530C>T	uc001lkx.3	+	5	1066	c.1066C>T	c.(1066-1068)CGC>TGC	p.R356C		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TCATGCTTTACGCCGAATGGA	0.527		NaN											0	0	0	0.003163	0	15	16									
ATHL1	80162	broad.mit.edu	37	11	294604	294604	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:294604C>T	uc010qvu.1	+	14	2184	c.2069C>T	c.(2068-2070)CCC>CTC	p.P690L	ATHL1_uc001lor.3_Missense_Mutation_p.P442L|ATHL1_uc001lou.3_Missense_Mutation_p.P265L|ATHL1_uc001lov.3_Missense_Mutation_p.P151L	NM_025092	NP_079368	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1	690					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			liver(1)|central_nervous_system(1)|skin(1)	3		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		CAAATGTCACCCCCGAAGCTG	0.642		NaN											0	0	0	0.003954	0	27	124									
HRAS	3265	broad.mit.edu	37	11	534226	534226	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:534226C>T	uc001lpv.2	-	2	285	c.97G>A	c.(97-99)GAC>AAC	p.D33N	HRAS_uc010qvw.1_Missense_Mutation_p.D33N|HRAS_uc010qvx.1_Missense_Mutation_p.D33N|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	33	Effector region.				activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding			urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	ATAGTGGGGTCGTATTCGTCC	0.637		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.013537	0	13	25									
TMEM80	283232	broad.mit.edu	37	11	703012	703012	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:703012C>T	uc001lqr.2	+	5	506	c.369C>T	c.(367-369)ACC>ACT	p.T123T	TMEM80_uc001lqs.2_Silent_p.T115T|TMEM80_uc010qwi.1_Silent_p.T123T	NM_001042463	NP_001035928	Q96HE8	TMM80_HUMAN	transmembrane protein 80 isoform 2	123						integral to membrane					0		all_cancers(49;5.11e-06)|all_epithelial(84;0.00143)|Breast(177;0.00234)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;3.44e-27)|Epithelial(43;2.29e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.19e-20)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CGGCTGGCACCGCCCTCCTCT	0.692		NaN											0	0	0	0.013537	0	12	46									
TALDO1	6888	broad.mit.edu	37	11	763392	763392	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:763392C>T	uc001lqz.2	+	5	560	c.510C>T	c.(508-510)TTC>TTT	p.F170F	TALDO1_uc001lra.2_Silent_p.F170F	NM_006755	NP_006746	P37837	TALDO_HUMAN	transaldolase 1	170					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		CGTTACTCTTCTCCTTCGCCC	0.453		NaN											0	0	0	0.012213	0	31	55									
DUSP8	1850	broad.mit.edu	37	11	1586951	1586951	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:1586951C>T	uc001lts.2	-	2	234	c.106G>A	c.(106-108)GTG>ATG	p.V36M		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	36	Rhodanese.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		TTGTACTCCACGAAGGAGCGG	0.657		NaN											0	0	0	0.004007	0	15	102									
MRGPRE	116534	broad.mit.edu	37	11	3249906	3249906	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:3249906T>C	uc001lxq.3	-	2	431	c.121A>G	c.(121-123)AAT>GAT	p.N41D		NM_001039165	NP_001034254	Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	41	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(1)|ovary(1)	2		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTGCCCCATTCCCCAGCAGC	0.642		NaN											0	0	0	0.008361	0	28	46									
DENND5A	23258	broad.mit.edu	37	11	9161320	9161320	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:9161320G>A	uc001mhl.2	-	23	4017	c.3762C>T	c.(3760-3762)ATC>ATT	p.I1254I	DENND5A_uc001mhk.2_Silent_p.I597I|DENND5A_uc010rbw.1_3'UTR	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	1254	RUN 2.									liver(1)	1						TATGGTCTTTGATCAGTGCCA	0.527		NaN											0	0	0	0.004482	0	9	25									
ADM	133	broad.mit.edu	37	11	10327902	10327902	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:10327902G>A	uc001mik.1	+	3	889	c.272G>A	c.(271-273)CGA>CAA	p.R91Q	ADM_uc001mil.1_Missense_Mutation_p.R91Q|ADM_uc001mim.1_Missense_Mutation_p.R44Q	NM_001124	NP_001115	P35318	ADML_HUMAN	adrenomedullin precursor	91					blood circulation|cAMP biosynthetic process|female pregnancy|negative regulation of vasoconstriction|progesterone biosynthetic process|response to wounding	cytoplasm|extracellular space|soluble fraction	hormone activity			central_nervous_system(1)	1				all cancers(16;3.51e-65)|Epithelial(150;1.52e-62)|BRCA - Breast invasive adenocarcinoma(625;0.0257)		GCCCGCATCCGAGTCAAGCGC	0.647		NaN											0	0	0	0.012319	0	20	23									
USP47	55031	broad.mit.edu	37	11	11971470	11971470	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:11971470A>G	uc001mjs.2	+	23	4146	c.3383A>G	c.(3382-3384)AAA>AGA	p.K1128R	USP47_uc001mjr.2_Missense_Mutation_p.K1060R|USP47_uc009ygi.2_5'Flank	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1148					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		GTGTTTGCTAAAGGAATGACT	0.343		NaN											0	0	0	0.010729	0	11	29									
PDE3B	5140	broad.mit.edu	37	11	14666332	14666332	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:14666332C>T	uc001mln.2	+	1	1064	c.711C>T	c.(709-711)CTC>CTT	p.L237L	PDE3B_uc001mlm.2_Silent_p.L237L|PDE3B_uc010rcr.1_Silent_p.L237L|PSMA1_uc001mll.2_5'Flank	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	237	Helical; (Potential).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						TCACCAGCCTCGGGTCGCTGC	0.692		NaN											0	0	0	0.00308	0	7	22									
CYP2R1	120227	broad.mit.edu	37	11	14913753	14913753	+	Splice_Site	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:14913753G>C	uc001mlr.2	-	1	1	c.1_splice	c.e1-1	p.M1_splice	CYP2R1_uc001mlo.2_5'Flank|CYP2R1_uc001mlp.2_5'Flank|CYP2R1_uc001mlq.2_5'Flank	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,						hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	CTTCCACATCGGCCCGAGCTG	0.677		NaN											0	0	0	0.009096	0	3	16									
CCDC34	91057	broad.mit.edu	37	11	27360567	27360567	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:27360567T>C	uc001mrh.1	-	6	977	c.923A>G	c.(922-924)AAT>AGT	p.N308S		NM_030771	NP_110398	Q96HJ3	CCD34_HUMAN	coiled-coil domain containing 34 isoform 1	308											0						TGGATAGGAATTTCCACTGTA	0.338		NaN											0	0	0	0.00308	0	8	37									
LGR4	55366	broad.mit.edu	37	11	27389570	27389570	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:27389570G>A	uc001mrj.3	-	18	3185	c.2700C>T	c.(2698-2700)GGC>GGT	p.G900G	LGR4_uc001mrk.3_Silent_p.G876G	NM_018490	NP_060960	Q9BXB1	LGR4_HUMAN	leucine-rich repeat-containing G protein-coupled	900	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein-hormone receptor activity			ovary(1)	1						CCGACTGTGTGCCACAGTCGG	0.512		NaN											0	0	0	0.014323	0	24	44									
WT1	7490	broad.mit.edu	37	11	32410605	32410605	+	Nonstop_Mutation	SNP	C	C	G	rs148856160		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:32410605C>G	uc001mtn.1	-	10	1749	c.1553G>C	c.(1552-1554)TGA>TCA	p.*518S	WT1_uc001mtl.1_Nonstop_Mutation_p.*303S|WT1_uc001mtm.1_Nonstop_Mutation_p.*289S|WT1_uc001mto.1_Nonstop_Mutation_p.*515S|WT1_uc001mtp.1_Nonstop_Mutation_p.*501S|WT1_uc001mtq.1_Nonstop_Mutation_p.*498S|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	518					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GGAGACCCCTCAAAGCGCCAG	0.517		NaN	D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				0	0	0	0.004656	0	25	30									
HIPK3	10114	broad.mit.edu	37	11	33361046	33361046	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:33361046A>G	uc001mul.1	+	6	1849	c.1579A>G	c.(1579-1581)ATG>GTG	p.M527V	HIPK3_uc001mum.1_Missense_Mutation_p.M527V|HIPK3_uc009yjv.1_Missense_Mutation_p.M527V	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	527					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TTTTGTTAATATGAAACATCT	0.323		NaN											0	0	0	0.004656	0	22	88									
OR4C15	81309	broad.mit.edu	37	11	55322644	55322644	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:55322644A>G	uc010rig.1	+	1	862	c.862A>G	c.(862-864)AAA>GAA	p.K288E		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AGGGCGCTGGAAAGCTCTCTC	0.443		NaN								HNSCC(20;0.049)			0	0	0	0.007291	0	25	104									
OR8H1	219469	broad.mit.edu	37	11	56058202	56058202	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:56058202G>T	uc010rje.1	-	1	337	c.337C>A	c.(337-339)CTT>ATT	p.L113I		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GATGAGAGAAGAAAACATTCA	0.438		NaN											1	0	2.12542e-12	0.00632	2.27309e-12	28	92									
PRG2	5553	broad.mit.edu	37	11	57156559	57156559	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:57156559T>G	uc001njz.2	-	2	317	c.290A>C	c.(289-291)AAA>ACA	p.K97T	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Missense_Mutation_p.K97T|PRG2_uc001nkb.2_Missense_Mutation_p.K97T|PRG2_uc001nkd.2_Missense_Mutation_p.K97T|PRG2_uc001nkc.2_Missense_Mutation_p.K97T|PRG2_uc001nke.2_Missense_Mutation_p.K377T	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	97					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	GCCCACCACTTTTACTGTGTC	0.527		NaN											0	0	0	0.010504	0	20	99									
ZDHHC5	25921	broad.mit.edu	37	11	57467491	57467491	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:57467491G>A	uc001nkx.1	+	12	3392	c.2136G>A	c.(2134-2136)GAG>GAA	p.E712E	ZDHHC5_uc001nky.1_Silent_p.E659E|ZDHHC5_uc001nkz.1_Silent_p.E526E	NM_015457	NP_056272	Q9C0B5	ZDHC5_HUMAN	zinc finger, DHHC domain containing 5	712						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)	1						CCACCTATGAGATTTCGGTGT	0.647		NaN											0	0	0	0.008291	0	11	10									
ZFP91	80829	broad.mit.edu	37	11	58384270	58384270	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:58384270C>A	uc001nmx.3	+	10	1352	c.1184C>A	c.(1183-1185)ACT>AAT	p.T395N	ZFP91_uc001nmy.3_Missense_Mutation_p.T394N|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	395					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				ATGATTCACACTGGCGAGAAG	0.423		NaN											1	0	0.000274275	0.004482	0.000284165	7	36									
ZFP91	80829	broad.mit.edu	37	11	58384283	58384283	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:58384283A>G	uc001nmx.3	+	10	1365	c.1197A>G	c.(1195-1197)CCA>CCG	p.P399P	ZFP91_uc001nmy.3_Silent_p.P398P|ZFP91-CNTF_uc010rkm.1_RNA	NM_053023	NP_444251	Q96JP5	ZFP91_HUMAN	zinc finger protein 91	399					activation of NF-kappaB-inducing kinase activity|protein K63-linked ubiquitination	nucleus	nucleic acid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				GCGAGAAGCCATTACAGTGAG	0.438		NaN											0	0	0	0.006214	0	9	35									
MS4A14	84689	broad.mit.edu	37	11	60184148	60184148	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:60184148G>A	uc001npj.2	+	5	2272	c.1707G>A	c.(1705-1707)CAG>CAA	p.Q569Q	MS4A14_uc001npi.2_Silent_p.Q457Q|MS4A14_uc001npn.2_Silent_p.Q307Q|MS4A14_uc001npk.2_Silent_p.Q552Q|MS4A14_uc001npl.2_Silent_p.Q307Q|MS4A14_uc001npm.2_Silent_p.Q307Q	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	569	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						CTGAAGATCAGCAAGCCAAAG	0.438		NaN											0	0	0	0.004007	0	17	8									
DAK	26007	broad.mit.edu	37	11	61111381	61111381	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:61111381G>A	uc001nre.2	+	12	1293	c.1036G>A	c.(1036-1038)GGG>AGG	p.G346R	DDB1_uc010rlf.1_5'Flank|DAK_uc009ynm.1_Missense_Mutation_p.G276R	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	346					glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						CTCCATTACTGGGCGGAAGCG	0.622		NaN											0	0	0	0.00245	0	15	83									
SYT7	9066	broad.mit.edu	37	11	61318925	61318925	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:61318925T>C	uc001nrv.2	-	3	152	c.146A>G	c.(145-147)TAC>TGC	p.Y49C	SYT7_uc009ynr.2_Missense_Mutation_p.Y49C|SYT7_uc001nrx.1_RNA	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	49	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						GGAATTCTTGTAGCGTTTGCC	0.587		NaN											0	0	0	0.001855	0	12	63									
DAGLA	747	broad.mit.edu	37	11	61511362	61511362	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:61511362G>A	uc001nsa.2	+	20	2641	c.2530G>A	c.(2530-2532)GAC>AAC	p.D844N		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	844	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GCTGGCGGCCGACAGCCTGTC	0.667		NaN											0	0	0	0.01441	0	105	166									
MARK2	2011	broad.mit.edu	37	11	63672397	63672397	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:63672397C>T	uc001nxw.2	+	16	2395	c.1816C>T	c.(1816-1818)CGG>TGG	p.R606W	MARK2_uc001nxx.2_Missense_Mutation_p.R552W|MARK2_uc001nxy.2_Missense_Mutation_p.R551W|MARK2_uc001nxv.3_Missense_Mutation_p.R551W|MARK2_uc001nxz.3_Missense_Mutation_p.R572W|MARK2_uc009yoy.2_Missense_Mutation_p.R526W	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	606					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CCGACAGGTGCGGGACCAGCA	0.647		NaN											0	0	0	0.001168	0	5	86									
PLCB3	5331	broad.mit.edu	37	11	64023082	64023082	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:64023082C>T	uc001nzb.2	+	7	591	c.591C>T	c.(589-591)TTC>TTT	p.F197F	PLCB3_uc009ypg.1_Silent_p.F197F|PLCB3_uc009yph.1_Silent_p.F130F|PLCB3_uc009ypi.2_Silent_p.F197F	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	197					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GCCTCAAATTCAACCGGGTGT	0.642		NaN											0	0	0	0.010818	0	29	37									
PRDX5	25824	broad.mit.edu	37	11	64085722	64085722	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:64085722C>T	uc001nzu.2	+	1	154	c.35C>T	c.(34-36)TCA>TTA	p.S12L	TRMT112_uc001nzt.2_5'Flank|PRDX5_uc001nzv.2_Missense_Mutation_p.S12L|PRDX5_uc001nzw.2_Missense_Mutation_p.S12L|PRDX5_uc001nzx.2_5'Flank	NM_012094	NP_036226	P30044	PRDX5_HUMAN	peroxiredoxin 5 isoform a precursor	12					cell redox homeostasis|cellular response to reactive oxygen species|inflammatory response|negative regulation of apoptosis	cytosolic part|mitochondrion|peroxisome	caspase inhibitor activity|peroxidase activity|peroxiredoxin activity			breast(1)	1					Auranofin(DB00995)	CTGAGACGCTCAGCGGGCTAT	0.697		NaN											0	0	0	0.001984	0	6	39									
ATG2A	23130	broad.mit.edu	37	11	64669497	64669497	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:64669497G>A	uc001obx.2	-	29	4171	c.4056C>T	c.(4054-4056)GGC>GGT	p.G1352G	ATG2A_uc001obw.2_Silent_p.G117G	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1352							protein binding			ovary(1)|central_nervous_system(1)	2						TGTCTCCATCGCCCTCCTCTT	0.627		NaN											0	0	0	0.006214	0	8	95									
DPP3	10072	broad.mit.edu	37	11	66272161	66272161	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:66272161G>A	uc001oig.1	+	17	2019	c.1957G>A	c.(1957-1959)GAG>AAG	p.E653K	DPP3_uc001oif.1_Missense_Mutation_p.E653K|DPP3_uc010rpe.1_Missense_Mutation_p.E642K|DPP3_uc001oih.1_Silent_p.P20P	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	653					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						TGCGCCCCCCGAGTGCTTCCT	0.572		NaN											0	0	0	0.004656	0	28	73									
PC	5091	broad.mit.edu	37	11	66617203	66617203	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:66617203G>A	uc001ojn.1	-	19	3075	c.3026C>T	c.(3025-3027)TCA>TTA	p.S1009L	PC_uc001ojo.1_Missense_Mutation_p.S1009L|PC_uc001ojp.1_Missense_Mutation_p.S1009L|PC_uc001ojm.1_5'UTR	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	1009					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CATAGCTGCTGAGAGCACATC	0.622		NaN											0	0	0	0.006214	0	9	43									
RAD9A	5883	broad.mit.edu	37	11	67161232	67161232	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:67161232G>A	uc001okr.2	+	5	513	c.420G>A	c.(418-420)TCG>TCA	p.S140S	RAD9A_uc001oks.2_5'Flank	NM_004584	NP_004575	Q99638	RAD9A_HUMAN	RAD9 homolog	140					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding				0			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			ACCCAGCCTCGTGCCCCCACA	0.652		NaN						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					0	0	0	0.000602	0	5	9									
C2CD3	26005	broad.mit.edu	37	11	73849870	73849870	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:73849870G>A	uc001ouu.2	-	5	1077	c.850C>T	c.(850-852)CTG>TTG	p.L284L	C2CD3_uc001ouv.2_Silent_p.L284L	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	284						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					GAACTGTTCAGAAGGGACATC	0.438		NaN											0	0	0	0.001984	0	7	43									
C11orf82	220042	broad.mit.edu	37	11	82643785	82643785	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:82643785A>T	uc001ozt.2	+	6	1649	c.1405A>T	c.(1405-1407)ACT>TCT	p.T469S	C11orf82_uc010rsr.1_Missense_Mutation_p.T168S|C11orf82_uc010rss.1_Missense_Mutation_p.T168S|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	469					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						CCAGAGAACTACTGGAGCCCT	0.403		NaN											0	0	0	0.010504	0	19	25									
AMOTL1	154810	broad.mit.edu	37	11	94554952	94554952	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:94554952C>T	uc001pfb.2	+	4	1548	c.1378C>T	c.(1378-1380)CAG>TAG	p.Q460*	AMOTL1_uc001pfc.2_Nonsense_Mutation_p.Q410*	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	460	Potential.			LQ -> HE (in Ref. 2; AAH14126).		cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CCAGGAACTTCAGGGTTACTA	0.537		NaN											0	0	0	0.012213	0	27	33									
EXPH5	23086	broad.mit.edu	37	11	108383163	108383163	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:108383163C>G	uc001pkk.2	-	6	3182	c.3071G>C	c.(3070-3072)AGA>ACA	p.R1024T	EXPH5_uc010rvy.1_Missense_Mutation_p.R836T|EXPH5_uc010rvz.1_Missense_Mutation_p.R868T|EXPH5_uc010rwa.1_Missense_Mutation_p.R948T	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1024					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GCTTGATTTTCTTGGCAAGGT	0.398		NaN											0	0	0	0.014323	0	21	23									
C11orf53	341032	broad.mit.edu	37	11	111154990	111154990	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:111154990G>A	uc001plc.2	+	3	344	c.197G>A	c.(196-198)GGA>GAA	p.G66E		NM_198498	NP_940900	Q8IXP5	CK053_HUMAN	hypothetical protein LOC341032	66											0		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		GAGCCCTACGGAGACTACCGG	0.697		NaN											0	0	0	0.009718	0	44	28									
SNX19	399979	broad.mit.edu	37	11	130773221	130773221	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:130773221T>C	uc001qgk.3	-	8	3050	c.2502A>G	c.(2500-2502)GAA>GAG	p.E834E	SNX19_uc009zcw.2_Silent_p.E71E|SNX19_uc010sce.1_Silent_p.E214E|SNX19_uc010scf.1_Silent_p.E277E|SNX19_uc010scg.1_Silent_p.E71E	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	834					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		ATTTCCACTGTTCTGTTAGTA	0.453		NaN											0	0	0	0.00499	0	18	24									
RAD52	5893	broad.mit.edu	37	12	1025884	1025884	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:1025884G>A	uc001qis.1	-	8	760	c.646C>T	c.(646-648)CAC>TAC	p.H216Y	RAD52_uc001qit.1_RNA|RAD52_uc010sdt.1_Missense_Mutation_p.H139Y|RAD52_uc001qiu.1_Missense_Mutation_p.H216Y|RAD52_uc001qiv.1_RNA|RAD52_uc001qiw.1_RNA|RAD52_uc010sdu.1_Missense_Mutation_p.H216Y	NM_134424	NP_602296	P43351	RAD52_HUMAN	RAD52 homolog	216					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			AGCTGTGGGTGTCCCAGGGCC	0.582		NaN						Homologous_recombination					0	0	0	0.001855	0	13	42									
CACNA2D4	93589	broad.mit.edu	37	12	2017134	2017134	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:2017134C>T	uc001qjp.2	-	5	787	c.556G>A	c.(556-558)GAG>AAG	p.E186K	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.E186K	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	186	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		AGGAGGAACTCGGCGCCCAGC	0.602		NaN											0	0	0	0.010504	0	20	42									
CACNA1C	775	broad.mit.edu	37	12	2795357	2795357	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:2795357A>G	uc009zdu.1	+	48	6268	c.5955A>G	c.(5953-5955)GAA>GAG	p.E1985E	CACNA1C_uc009zdv.1_Silent_p.E1899E|CACNA1C_uc001qkb.2_Silent_p.E1902E|CACNA1C_uc001qkc.2_Silent_p.E1921E|CACNA1C_uc001qke.2_Silent_p.E1891E|CACNA1C_uc001qkf.2_Silent_p.E1910E|CACNA1C_uc001qjz.2_Silent_p.E1902E|CACNA1C_uc001qkd.2_Silent_p.E1921E|CACNA1C_uc001qkg.2_Silent_p.E1908E|CACNA1C_uc009zdw.1_Silent_p.E1943E|CACNA1C_uc001qkh.2_Silent_p.E1910E|CACNA1C_uc001qkl.2_Silent_p.E1950E|CACNA1C_uc001qkn.2_Silent_p.E1902E|CACNA1C_uc001qko.2_Silent_p.E1922E|CACNA1C_uc001qkp.2_Silent_p.E1902E|CACNA1C_uc001qkr.2_Silent_p.E1919E|CACNA1C_uc001qku.2_Silent_p.E1937E|CACNA1C_uc001qkq.2_Silent_p.E1930E|CACNA1C_uc001qks.2_Silent_p.E1902E|CACNA1C_uc001qkt.2_Silent_p.E1921E|CACNA1C_uc001qki.1_Silent_p.E1709E|CACNA1C_uc001qkj.1_Silent_p.E1673E|CACNA1C_uc001qkk.1_Silent_p.E1638E|CACNA1C_uc001qkm.1_Silent_p.E1698E|CACNA1C_uc010sea.1_Silent_p.E593E|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Silent_p.E220E	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1985	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCCACCTGGAATGTCTGAAGC	0.562		NaN											0	0	0	0.004656	0	25	81									
TNFRSF1A	7132	broad.mit.edu	37	12	6442925	6442925	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:6442925G>A	uc001qnu.2	-	3	581	c.300C>T	c.(298-300)CTC>CTT	p.L100L	TNFRSF1A_uc001qnt.2_5'UTR|TNFRSF1A_uc010sey.1_Intron|TNFRSF1A_uc010sez.1_5'UTR|TNFRSF1A_uc009zek.2_Intron|TNFRSF1A_uc010sfa.1_Silent_p.L100L	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	100	TNFR-Cys 2.|Extracellular (Potential).				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			lung(2)|skin(1)	3						TGGAGCAGCTGAGGCAGTGTC	0.592		NaN											0	0	0	0.004672	0	3	3									
NOP2	4839	broad.mit.edu	37	12	6675746	6675746	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:6675746T>C	uc001qpk.1	-	3	231	c.187A>G	c.(187-189)AAG>GAG	p.K63E	NOP2_uc001qph.1_Missense_Mutation_p.K63E|NOP2_uc001qpi.1_Missense_Mutation_p.K63E|NOP2_uc001qpj.1_Intron|NOP2_uc001qpl.1_Missense_Mutation_p.K63E|NOP2_uc001qpm.1_Missense_Mutation_p.K63E			P46087	NOP2_HUMAN	Homo sapiens cDNA FLJ31646 fis, clone NT2RI2003921, highly similar to PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120.	63					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						TTATTTGTCTTAGGGGCTTCA	0.488		NaN											0	0	0	0.00632	0	25	34									
C1R	715	broad.mit.edu	37	12	7244200	7244200	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:7244200C>T	uc010sfy.1	-	2	138	c.79G>A	c.(79-81)GGG>AGG	p.G27R	C1R_uc010sfz.1_Missense_Mutation_p.G41R|C1R_uc010sga.1_Missense_Mutation_p.G27R	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	27	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GTCACCTCCCCAAATAACTTC	0.537		NaN											0	0	0	0.009096	0	4	3									
DUSP16	80824	broad.mit.edu	37	12	12674023	12674023	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:12674023C>T	uc001rao.1	-	2	642	c.10G>A	c.(10-12)GAG>AAG	p.E4K	DUSP16_uc001ran.1_5'UTR	NM_030640	NP_085143	Q9BY84	DUS16_HUMAN	dual specificity phosphatase 16	4					inactivation of MAPK activity|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive	cytoplasmic membrane-bounded vesicle|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		Prostate(47;0.0687)		BRCA - Breast invasive adenocarcinoma(232;0.0203)		CCAATCATCTCATGGGCCATG	0.453		NaN											0	0	0	0.010729	0	11	17									
PDE3A	5139	broad.mit.edu	37	12	20523043	20523043	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:20523043G>A	uc001reh.1	+	1	847	c.825G>A	c.(823-825)CTG>CTA	p.L275L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627		NaN											0	0	0	0.008361	0	23	41									
PDE3A	5139	broad.mit.edu	37	12	20799433	20799433	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:20799433G>A	uc001reh.1	+	11	2283	c.2261G>A	c.(2260-2262)AGA>AAA	p.R754K		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	754	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GATCATAACAGAATCCATGCC	0.413		NaN											0	0	0	0.008361	0	27	35									
DENND5B	160518	broad.mit.edu	37	12	31595714	31595714	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:31595714A>C	uc001rki.1	-	7	2193	c.2007T>G	c.(2005-2007)AGT>AGG	p.S669R	DENND5B_uc001rkh.1_Missense_Mutation_p.S704R|DENND5B_uc009zjq.1_Intron|DENND5B_uc001rkj.2_Missense_Mutation_p.S691R	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	669						integral to membrane				ovary(1)|central_nervous_system(1)	2						CTTACTTGTTACTGGTTGGTC	0.418		NaN											0	0	0	0.001984	0	6	20									
YARS2	51067	broad.mit.edu	37	12	32906904	32906904	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:32906904G>A	uc001rli.2	-	2	961	c.895C>T	c.(895-897)CCA>TCA	p.P299S		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	299					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	AATTCAAATGGAGATGTCTTA	0.418		NaN											0	0	0	0.003755	0	33	69									
SLC2A13	114134	broad.mit.edu	37	12	40499284	40499284	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:40499284G>A	uc010skm.1	-	1	378	c.327C>T	c.(325-327)CTC>CTT	p.L109L	SLC2A13_uc001rmf.2_Silent_p.L109L	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	109	Extracellular (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				GCTGCCGCTTGAGCAGCAGCA	0.697		NaN								HNSCC(50;0.14)			0	0	0	0.004672	0	3	3									
LRRK2	120892	broad.mit.edu	37	12	40748212	40748212	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:40748212G>A	uc001rmg.3	+	45	6809	c.6688G>A	c.(6688-6690)GAA>AAA	p.E2230K	LRRK2_uc009zjw.2_Missense_Mutation_p.E1068K|LRRK2_uc001rmi.2_Missense_Mutation_p.E1063K	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2230					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CATCAATACCGAAGATGGGAA	0.408		NaN											0	0	0	0.00308	0	8	23									
CNTN1	1272	broad.mit.edu	37	12	41327360	41327360	+	Silent	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:41327360A>T	uc001rmm.1	+	8	914	c.801A>T	c.(799-801)GGA>GGT	p.G267G	CNTN1_uc009zjy.1_Silent_p.G267G|CNTN1_uc001rmn.1_Silent_p.G256G|CNTN1_uc001rmo.2_Silent_p.G267G	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	267	Ig-like C2-type 3.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTGCACTTGGAAAGTAAGTAT	0.284		NaN											0	0	0	0.00333	0	24	67									
ARID2	196528	broad.mit.edu	37	12	46287315	46287315	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:46287315C>T	uc001ros.1	+	19	5260	c.5260C>T	c.(5260-5262)CGA>TGA	p.R1754*	ARID2_uc001ror.2_Nonsense_Mutation_p.R1754*|ARID2_uc009zkg.1_Nonsense_Mutation_p.R1210*|ARID2_uc009zkh.1_Nonsense_Mutation_p.R1381*|ARID2_uc001rou.1_Nonsense_Mutation_p.R1088*	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1754					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CCTTGTCTTTCGAGATTTTAC	0.403		NaN											0	0	0	0.005443	0	26	36									
H1FNT	341567	broad.mit.edu	37	12	48723371	48723371	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:48723371G>A	uc001rrm.2	+	1	609	c.297G>A	c.(295-297)GCG>GCA	p.A99A		NM_181788	NP_861453	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	99					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			pancreas(1)	1						GCCACGAAGCGCCCAGGGGGC	0.667		NaN											0	0	0	0.00278	0	17	19									
TROAP	10024	broad.mit.edu	37	12	49719543	49719543	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:49719543C>G	uc001rtx.3	+	5	676	c.509C>G	c.(508-510)TCT>TGT	p.S170C	TROAP_uc009zlh.2_Missense_Mutation_p.S170C|TROAP_uc001rty.2_5'Flank	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	170					cell adhesion	cytoplasm				ovary(1)	1						GTTCGGGCCTCTGCATATTTG	0.622		NaN											0	0	0	0.013537	0	12	36									
LIMA1	51474	broad.mit.edu	37	12	50571638	50571638	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:50571638G>A	uc001rwj.3	-	11	1663	c.1489C>T	c.(1489-1491)CCT>TCT	p.P497S	LIMA1_uc001rwg.3_Missense_Mutation_p.P195S|LIMA1_uc001rwh.3_Missense_Mutation_p.P336S|LIMA1_uc001rwi.3_Missense_Mutation_p.P338S|LIMA1_uc001rwk.3_Missense_Mutation_p.P498S|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	497					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						TTAGCAATAGGGGCATCTTCT	0.522		NaN											0	0	0	0.009718	0	45	85									
SLC11A2	4891	broad.mit.edu	37	12	51384657	51384657	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:51384657A>G	uc001rxe.3	-	15	1593	c.1496T>C	c.(1495-1497)GTC>GCC	p.V499A	SLC11A2_uc001rxd.3_Missense_Mutation_p.V348A|SLC11A2_uc001rxc.3_Missense_Mutation_p.V499A|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_Missense_Mutation_p.V112A|SLC11A2_uc010smx.1_Missense_Mutation_p.V495A|SLC11A2_uc001rxh.1_Missense_Mutation_p.V499A|SLC11A2_uc001rxj.1_Missense_Mutation_p.V499A|SLC11A2_uc001rxi.2_Missense_Mutation_p.V499A|SLC11A2_uc001rxk.1_Missense_Mutation_p.V528A|SLC11A2_uc010smy.1_Missense_Mutation_p.V462A	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	499	Helical; (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						TAGGTCCCGGACATAAACCAC	0.478		NaN											0	0	0	0.008871	0	20	38									
KRT7	3855	broad.mit.edu	37	12	52627001	52627001	+	Translation_Start_Site	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:52627001A>G	uc001saa.1	+	1	48	c.-79A>G	c.(-81--77)ATAAA>ATGAA		KRT7_uc009zmf.1_Translation_Start_Site	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7						cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		TCCCGCGGATAAAAGGCGCGG	0.731		NaN											0	0	0	0.000602	0	5	2									
KRT84	3890	broad.mit.edu	37	12	52777374	52777374	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:52777374T>C	uc001sah.1	-	2	803	c.755A>G	c.(754-756)AAG>AGG	p.K252R		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	252	Rod.|Coil 1B.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTCACTCACTTCTTCTTGAA	0.582		NaN											0	0	0	0.001168	0	6	30									
KRT3	3850	broad.mit.edu	37	12	53186528	53186528	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:53186528A>G	uc001say.2	-	4	1056	c.990T>C	c.(988-990)GAT>GAC	p.D330D		NM_057088	NP_476429	P12035	K2C3_HUMAN	keratin 3	330	Rod.|Coil 1B.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity				0						AGTCGATCTCATCTATCAAGG	0.473		NaN											0	0	0	0.01441	0	70	154									
CALCOCO1	57658	broad.mit.edu	37	12	54115352	54115352	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:54115352C>T	uc001sef.2	-	6	801	c.657G>A	c.(655-657)CTG>CTA	p.L219L	CALCOCO1_uc010som.1_Silent_p.L186L|CALCOCO1_uc010son.1_Silent_p.L96L|CALCOCO1_uc001seh.2_Silent_p.L219L|CALCOCO1_uc009znd.2_Silent_p.L219L|CALCOCO1_uc001seg.2_Silent_p.L96L|CALCOCO1_uc010soo.1_Silent_p.L212L	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	219					steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						GTTGCCGGCTCAGGATGTCCC	0.537		NaN											0	0	0	0.01441	0	138	260									
HOXC9	3225	broad.mit.edu	37	12	54394372	54394372	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:54394372G>A	uc001sep.2	+	2	498	c.400G>A	c.(400-402)GAG>AAG	p.E134K	HOXC9_uc001seq.2_Missense_Mutation_p.E134K	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	134					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						CGGCCCAGGGGAGGGCCGCAG	0.781		NaN											0	0	0	0.000602	0	4	2									
HOXC5	3222	broad.mit.edu	37	12	54428131	54428131	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:54428131A>T	uc001sew.2	+	2	599	c.524A>T	c.(523-525)CAC>CTC	p.H175L	HOXC5_uc001set.2_RNA|HOXC4_uc001seu.2_Intron	NM_018953	NP_061826	Q00444	HXC5_HUMAN	homeobox C5	175	Homeobox.				regulation of transcription from RNA polymerase II promoter	cell junction|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAAGAATTCCACTTTAACCGC	0.537		NaN											0	0	0	0.01441	0	47	76									
OR6C1	390321	broad.mit.edu	37	12	55714720	55714720	+	Silent	SNP	C	C	T	rs149008799		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:55714720C>T	uc010spi.1	+	1	337	c.337C>T	c.(337-339)CTG>TTG	p.L113L		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						GTTTTACCTTCTGGCTGCCAT	0.403		NaN											0	0	0	0.008291	0	11	28									
OR6C65	403282	broad.mit.edu	37	12	55794973	55794973	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:55794973A>G	uc010spl.1	+	1	661	c.661A>G	c.(661-663)AAA>GAA	p.K221E		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTCATCCTTAAAACAATTCT	0.418		NaN											0	0	0	0.004878	0	36	93									
OR6C2	341416	broad.mit.edu	37	12	55846108	55846108	+	Silent	SNP	A	A	G	rs142313431		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:55846108A>G	uc001sgz.1	+	1	111	c.111A>G	c.(109-111)GTA>GTG	p.V37V		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TGTTGAGTGTAACAGGGAACC	0.403		NaN											0	0	0	0.010504	0	20	42									
SUOX	6821	broad.mit.edu	37	12	56396035	56396035	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:56396035C>T	uc001six.2	+	4	356	c.30C>T	c.(28-30)CTC>CTT	p.L10L	SUOX_uc009zoh.2_Silent_p.L10L|SUOX_uc001siy.2_Silent_p.L10L|SUOX_uc001siz.2_Silent_p.L10L|SUOX_uc001sja.2_Silent_p.L10L	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	10						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			CTGTGGTCCTCAGGCTCCAAC	0.547		NaN											0	0	0	0.014323	0	21	45									
PPM1H	57460	broad.mit.edu	37	12	63195923	63195923	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:63195923G>A	uc001srk.3	-	3	578	c.429C>T	c.(427-429)TCC>TCT	p.S143S		NM_020700	NP_065751	Q9ULR3	PPM1H_HUMAN	protein phosphatase 1H (PP2C domain containing)	143	PP2C-like.						phosphoprotein phosphatase activity			lung(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		AATAGTGGCAGGAAACACCCT	0.617		NaN											0	0	0	0.009096	0	3	24									
LGR5	8549	broad.mit.edu	37	12	71833861	71833861	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:71833861A>G	uc001swl.2	+	1	49	c.1A>G	c.(1-3)ATG>GTG	p.M1V	TSPAN8_uc001swk.1_Intron|LGR5_uc001swm.2_Missense_Mutation_p.M1V|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	1						integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						TTCGGGCACCATGGACACCTC	0.721		NaN											0	0	0	0.007291	0	28	38									
TMEM19	55266	broad.mit.edu	37	12	72080580	72080580	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:72080580C>A	uc001sws.2	+	1	703	c.120C>A	c.(118-120)AGC>AGA	p.S40R	TMEM19_uc001swr.1_Missense_Mutation_p.S26R|TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	40						integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		TGACTGCAAGCACCTATTATG	0.318		NaN											1	0	0.000274275	0.004482	0.000284165	7	49									
SYT1	6857	broad.mit.edu	37	12	79689917	79689917	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:79689917C>G	uc001sys.2	+	8	1214	c.543C>G	c.(541-543)TAC>TAG	p.Y181*	SYT1_uc001syt.2_Nonsense_Mutation_p.Y181*|SYT1_uc001syu.2_Nonsense_Mutation_p.Y178*|SYT1_uc001syv.2_Nonsense_Mutation_p.Y181*	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	181	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						CTGATCCTTACGTGAAAGTGT	0.433		NaN											0	0	0	0.010818	0	31	40									
PPFIA2	8499	broad.mit.edu	37	12	82147869	82147869	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:82147869A>G	uc001szo.1	-	3	293	c.132T>C	c.(130-132)CGT>CGC	p.R44R	PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(3)|lung(2)|pancreas(1)	6						TGTCTAGAAGACGATCCCTTT	0.527		NaN											0	0	0	0.009096	0	4	25									
CEP290	80184	broad.mit.edu	37	12	88482816	88482816	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:88482816G>C	uc001tar.2	-	31	4366	c.4022C>G	c.(4021-4023)GCC>GGC	p.A1341G	CEP290_uc001taq.2_Missense_Mutation_p.A401G	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	1341	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						TACCTTTTGGGCTCCTTTGGT	0.209		NaN											0	0	0	0.00499	0	16	29									
KERA	11081	broad.mit.edu	37	12	91449642	91449642	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:91449642T>C	uc001tbl.2	-	2	1036	c.417A>G	c.(415-417)CCA>CCG	p.P139P		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	139	LRR 3.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						TTCTTGGCAATGGAGAAGGTA	0.413		NaN											0	0	0	0.00333	0	25	84									
METAP2	10988	broad.mit.edu	37	12	95907493	95907493	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:95907493G>A	uc001tec.2	+	11	1384	c.1250G>A	c.(1249-1251)CGC>CAC	p.R417H	METAP2_uc010suv.1_Missense_Mutation_p.R394H|METAP2_uc009ztd.2_Missense_Mutation_p.R381H|METAP2_uc001ted.2_Missense_Mutation_p.R416H|METAP2_uc001tef.2_Missense_Mutation_p.R394H|METAP2_uc001tee.2_RNA	NM_006838	NP_006829	P50579	AMPM2_HUMAN	methionyl aminopeptidase 2	417					N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0					L-Methionine(DB00134)	GCCTTCTGCCGCAGATGGCTG	0.408		NaN											0	0	0	0.009096	0	4	76									
HAL	3034	broad.mit.edu	37	12	96374496	96374496	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:96374496G>C	uc001tem.1	-	17	1654	c.1357C>G	c.(1357-1359)CTA>GTA	p.L453V	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Missense_Mutation_p.L245V|HAL_uc010sux.1_Missense_Mutation_p.L453V	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	453					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	AAGTAGTCTAGGGCCTGAAAG	0.493		NaN											0	0	0	0.005443	0	20	72									
MYBPC1	4604	broad.mit.edu	37	12	102036322	102036322	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:102036322A>G	uc001tii.2	+	9	818	c.716A>G	c.(715-717)AAG>AGG	p.K239R	MYBPC1_uc001tif.1_Missense_Mutation_p.K252R|MYBPC1_uc001tig.2_Missense_Mutation_p.K264R|MYBPC1_uc010svq.1_Missense_Mutation_p.K226R|MYBPC1_uc001tih.2_Missense_Mutation_p.K264R|MYBPC1_uc001tij.2_Missense_Mutation_p.K239R|MYBPC1_uc010svr.1_Missense_Mutation_p.K239R|MYBPC1_uc010svs.1_Missense_Mutation_p.K239R|MYBPC1_uc010svt.1_Missense_Mutation_p.K227R|MYBPC1_uc010svu.1_Missense_Mutation_p.K220R|MYBPC1_uc001tik.2_Missense_Mutation_p.K213R	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	239					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						GGCATGCTCAAGCGACTCAAG	0.627		NaN											0	0	0	0.001855	0	14	26									
CHPT1	56994	broad.mit.edu	37	12	102107950	102107950	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:102107950G>A	uc001tin.2	+	2	579	c.356G>A	c.(355-357)AGA>AAA	p.R119K	CHPT1_uc001tio.2_RNA|CHPT1_uc001tip.1_Missense_Mutation_p.R119K	NM_020244	NP_064629	Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	119					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding				0						AAACAAGCCAGAAGAACAAAC	0.378		NaN											0	0	0	0.01441	0	52	124									
HSP90B1	7184	broad.mit.edu	37	12	104336508	104336508	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:104336508G>A	uc001tkb.1	+	12	1683	c.1578G>A	c.(1576-1578)CAG>CAA	p.Q526Q	HSP90B1_uc010swg.1_Silent_p.Q191Q|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	526					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	GCCTAGACCAGTATGTGGAAA	0.423		NaN											0	0	0	0.006122	0	18	60									
MTERFD3	80298	broad.mit.edu	37	12	107371523	107371523	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:107371523C>T	uc001tme.1	-	2	2789	c.970G>A	c.(970-972)GAA>AAA	p.E324K	MTERFD3_uc001tmf.1_Missense_Mutation_p.E324K|MTERFD3_uc001tmg.1_Missense_Mutation_p.E324K|MTERFD3_uc001tmh.1_Missense_Mutation_p.E324K	NM_025198	NP_079474	Q49AM1	MTER3_HUMAN	transcription termination factor-like protein	324					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	transcription regulatory region DNA binding				0						GGTGTTAATTCAAGAACCATT	0.358		NaN											0	0	0	0.006999	0	38	106									
CORO1C	23603	broad.mit.edu	37	12	109052672	109052672	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:109052672A>C	uc001tnj.2	-	5	568	c.472T>G	c.(472-474)TGG>GGG	p.W158G	CORO1C_uc009zva.2_Missense_Mutation_p.W211G|CORO1C_uc010sxf.1_Intron	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	158	WD 2.				actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						CCCACATTCCAGATGATAATG	0.413		NaN											0	0	0	0.012319	0	20	61									
UBE3B	89910	broad.mit.edu	37	12	109935646	109935646	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:109935646C>T	uc001top.2	+	10	1340	c.737C>T	c.(736-738)TCA>TTA	p.S246L	UBE3B_uc001toq.2_Missense_Mutation_p.S246L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.S246L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	246					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GCACAGTTCTCAGACAATCTG	0.527		NaN											0	0	0	0.010818	0	32	90									
UBE3B	89910	broad.mit.edu	37	12	109940962	109940962	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:109940962A>G	uc001top.2	+	14	2020	c.1417A>G	c.(1417-1419)ACT>GCT	p.T473A	UBE3B_uc001toq.2_Missense_Mutation_p.T473A|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.T473A	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	473					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CTCGCTGACAACTCTCACACA	0.517		NaN											0	0	0	0.013537	0	12	39									
OAS2	4939	broad.mit.edu	37	12	113442824	113442824	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:113442824C>A	uc001tuj.2	+	7	1405	c.1265C>A	c.(1264-1266)ACC>AAC	p.T422N	OAS2_uc001tui.1_Missense_Mutation_p.T422N	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	422	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						AAAAGCTACACCTCCCAAAAA	0.488		NaN											1	0	1.67942e-08	0.006122	1.77192e-08	19	34									
DNAH10	196385	broad.mit.edu	37	12	124311275	124311275	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:124311275G>A	uc001uft.3	+	24	3892	c.3867G>A	c.(3865-3867)CTG>CTA	p.L1289L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1289	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGATCAACCTGAATGTGCAGA	0.478		NaN											0	0	0	0.004878	0	38	85									
GOLGA3	2802	broad.mit.edu	37	12	133351795	133351795	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:133351795T>G	uc001ukz.1	-	22	4634	c.4075A>C	c.(4075-4077)AAC>CAC	p.N1359H	GOLGA3_uc001ula.1_Missense_Mutation_p.N1359H	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1359	Potential.|Gln-rich.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GTCTTCATGTTGTTCTTCAGC	0.582		NaN											0	0	0	0.003163	0	16	50									
MPHOSPH8	54737	broad.mit.edu	37	13	20220640	20220640	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20220640G>C	uc001umh.2	+	3	436	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	MPHOSPH8_uc001umf.1_Missense_Mutation_p.E143Q|MPHOSPH8_uc001umg.2_Missense_Mutation_p.E143Q|MPHOSPH8_uc001umi.2_5'UTR	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	143					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		TCAGCAAAGTGAGACAAAAGA	0.338		NaN											0	0	0	0.001168	0	5	32									
MPHOSPH8	54737	broad.mit.edu	37	13	20220723	20220723	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20220723G>A	uc001umh.2	+	3	519	c.510G>A	c.(508-510)AAG>AAA	p.K170K	MPHOSPH8_uc001umf.1_Silent_p.K170K|MPHOSPH8_uc001umg.2_Silent_p.K170K|MPHOSPH8_uc001umi.2_5'UTR	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	170	Lys-rich.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		ATCTGAAAAAGAAAAAAGCAA	0.378		NaN											0	0	0	0.001984	0	6	33									
MPHOSPH8	54737	broad.mit.edu	37	13	20220818	20220818	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20220818G>C	uc001umh.2	+	3	614	c.605G>C	c.(604-606)AGA>ACA	p.R202T	MPHOSPH8_uc001umf.1_Missense_Mutation_p.R202T|MPHOSPH8_uc001umg.2_Missense_Mutation_p.R202T|MPHOSPH8_uc001umi.2_5'UTR	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	202	Lys-rich.				cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		ACAAAGAAAAGAATTTCTGAA	0.279		NaN											0	0	0	0.00308	0	8	26									
MPHOSPH8	54737	broad.mit.edu	37	13	20221193	20221193	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20221193G>C	uc001umh.2	+	3	989	c.980G>C	c.(979-981)AGA>ACA	p.R327T	MPHOSPH8_uc001umf.1_Missense_Mutation_p.R327T|MPHOSPH8_uc001umg.2_Missense_Mutation_p.R327T|MPHOSPH8_uc001umi.2_Missense_Mutation_p.R24T	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	327					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		ACCGATGTCAGAGGCAGGAGG	0.512		NaN											0	0	0	0.001984	0	5	38									
ZMYM2	7750	broad.mit.edu	37	13	20633593	20633593	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:20633593C>T	uc001umr.2	+	17	2928	c.2630C>T	c.(2629-2631)ACT>ATT	p.T877I	ZMYM2_uc001ums.2_Missense_Mutation_p.T877I|ZMYM2_uc001umt.2_Missense_Mutation_p.T877I|ZMYM2_uc010tco.1_RNA|ZMYM2_uc001umv.2_Missense_Mutation_p.T257I|ZMYM2_uc001umw.2_Missense_Mutation_p.T330I	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	877					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		TTAGATGATACTTGGAGGACA	0.338		NaN											0	0	0	0.013537	0	12	28									
PDX1	3651	broad.mit.edu	37	13	28494606	28494606	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:28494606G>A	uc001urt.2	+	1	439	c.331G>A	c.(331-333)GAG>AAG	p.E111K	uc001urs.1_Intron	NM_000209	NP_000200	P52945	PDX1_HUMAN	pancreatic and duodenal homeobox 1	111					detection of glucose|generation of precursor metabolites and energy|insulin secretion|nitric oxide mediated signal transduction|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|type B pancreatic cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity				0	all_cancers(110;0.175)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		CGTCCTGGAGGAGCCCAACCG	0.701		NaN											0	0	0	0.001984	0	6	6									
PDS5B	23047	broad.mit.edu	37	13	33327664	33327664	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:33327664A>G	uc010abf.2	+	25	3089	c.2931A>G	c.(2929-2931)GCA>GCG	p.A977A	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	977					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AGCAGCATGCAGCTGTTAGTG	0.363		NaN											0	0	0	0.004672	0	3	28									
KL	9365	broad.mit.edu	37	13	33635170	33635170	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:33635170G>A	uc001uus.2	+	4	1962	c.1954G>A	c.(1954-1956)GCC>ACC	p.A652T	KL_uc001uur.1_3'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	652	Glycosyl hydrolase-1 2.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GCGCCTCCTGGCCAGGCAGGG	0.627		NaN											0	0	0	0.013537	0	12	61									
FAM48A	55578	broad.mit.edu	37	13	37603934	37603934	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:37603934C>T	uc001uwg.2	-	13	1209	c.961G>A	c.(961-963)GAT>AAT	p.D321N	FAM48A_uc010abt.2_Missense_Mutation_p.D322N|FAM48A_uc001uwh.2_Missense_Mutation_p.D322N|FAM48A_uc001uwi.2_Missense_Mutation_p.D321N|FAM48A_uc001uwj.2_Missense_Mutation_p.D322N|FAM48A_uc001uwk.2_Missense_Mutation_p.D321N|FAM48A_uc010tes.1_Intron|FAM48A_uc001uwl.1_Missense_Mutation_p.D321N	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	321					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		TGTGAGTCATCAGATTTGATA	0.348		NaN											0	0	0	0.004482	0	8	46									
FREM2	341640	broad.mit.edu	37	13	39262253	39262253	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:39262253G>A	uc001uwv.2	+	1	1081	c.772G>A	c.(772-774)GCT>ACT	p.A258T		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	258	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGACTGCAAAGCTTTCCAGGA	0.642		NaN											0	0	0	0.012319	0	19	79									
NHLRC3	387921	broad.mit.edu	37	13	39621938	39621938	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:39621938C>T	uc001uxc.2	+	7	1241	c.919C>T	c.(919-921)CAA>TAA	p.Q307*	NHLRC3_uc001uxd.2_Nonsense_Mutation_p.Q240*|NHLRC3_uc001uxe.2_Nonsense_Mutation_p.Q110*	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	307	NHL 4.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		ACTAGCAGATCAAGTTTTGCC	0.468		NaN											0	0	0	0.012319	0	18	43									
FOXO1	2308	broad.mit.edu	37	13	41134387	41134387	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:41134387A>G	uc001uxl.3	-	2	1626	c.1241T>C	c.(1240-1242)TTG>TCG	p.L414S	FOXO1_uc010acc.1_Missense_Mutation_p.L229S	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	414					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		GGGTGAATTCAAACTGGTGTT	0.488		NaN											0	0	0	0.005443	0	22	93									
KIAA0564	23078	broad.mit.edu	37	13	42189117	42189117	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:42189117C>T	uc001uyj.2	-	38	4785	c.4715G>A	c.(4714-4716)GGA>GAA	p.G1572E		NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	1572						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		CCAACCTGTTCCGCCAGCCCA	0.577		NaN											0	0	0	0.004482	0	9	42									
DGKH	160851	broad.mit.edu	37	13	42763216	42763216	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:42763216G>A	uc001uyl.1	+	15	1704	c.1683G>A	c.(1681-1683)TTG>TTA	p.L561L	DGKH_uc010tfh.1_Silent_p.L561L|DGKH_uc001uym.1_Silent_p.L561L|DGKH_uc010tfi.1_Silent_p.L316L|DGKH_uc010tfj.1_Silent_p.L416L|DGKH_uc001uyn.1_RNA|DGKH_uc001uyo.1_Silent_p.L416L|DGKH_uc001uyp.2_RNA	NM_178009	NP_821077	Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta isoform 2	561					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(2)	2		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TGCAGGCTTTGCACACAGATT	0.483		NaN											0	0	0	0.006214	0	8	32									
CPB2	1361	broad.mit.edu	37	13	46661885	46661885	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:46661885A>G	uc001vaw.2	-	2	212	c.145T>C	c.(145-147)TAT>CAT	p.Y49H	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Missense_Mutation_p.Y49H	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	49					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		ATTACCTCATATGTTGTAGTA	0.373		NaN											0	0	0	0.01441	0	42	56									
SETDB2	83852	broad.mit.edu	37	13	50050956	50050956	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:50050956A>T	uc001vcz.2	+	7	1592	c.686A>T	c.(685-687)CAG>CTG	p.Q229L	SETDB2_uc010adg.2_Missense_Mutation_p.Q205L|SETDB2_uc001vcy.3_Missense_Mutation_p.Q217L|SETDB2_uc010adh.2_Missense_Mutation_p.Q217L|SETDB2_uc001vda.2_Missense_Mutation_p.Q217L	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	229	MBD.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		ACCTATGTTCAGTTGGCTCGG	0.378		NaN											0	0	0	0.013726	0	34	49									
CKAP2	26586	broad.mit.edu	37	13	53035696	53035696	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:53035696A>G	uc001vgv.2	+	4	935	c.738A>G	c.(736-738)ACA>ACG	p.T246T	CKAP2_uc001vgt.2_Silent_p.T245T|CKAP2_uc001vgu.2_Silent_p.T245T|CKAP2_uc010tha.1_Silent_p.T197T	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	246					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		TGAGCACTACATCTCAGAACA	0.423		NaN											0	0	0	0.010729	0	9	30									
MYCBP2	23077	broad.mit.edu	37	13	77669735	77669735	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:77669735G>A	uc001vkf.2	-	59	9934	c.9843C>T	c.(9841-9843)GTC>GTT	p.V3281V	MYCBP2_uc010aev.2_Silent_p.V2685V|MYCBP2_uc001vke.2_5'Flank	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	3281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TAGATTGTTTGACCTGGCGAA	0.373		NaN											0	0	0	0.004656	0	24	33									
MYCBP2	23077	broad.mit.edu	37	13	77852999	77852999	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:77852999T>C	uc001vkf.2	-	5	619	c.528A>G	c.(526-528)ACA>ACG	p.T176T	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GAGAAAATCGTGTCTCTTTGA	0.438		NaN											0	0	0	0.006122	0	16	29									
RAP2A	5911	broad.mit.edu	37	13	98086808	98086808	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:98086808C>T	uc001vnd.2	+	1	334	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	28					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			CCGGCACCTTCATCGAGAAAT	0.597		NaN											0	0	0	0.013726	0	33	105									
FARP1	10160	broad.mit.edu	37	13	99083317	99083317	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:99083317G>A	uc001vnj.2	+	18	2262	c.1926G>A	c.(1924-1926)TGG>TGA	p.W642*	FARP1_uc001vnh.2_Nonsense_Mutation_p.W642*	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	642	DH.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CTCACCTGTGGAAGCACAGCG	0.577		NaN											0	0	0	0.010729	0	11	46									
CUL4A	8451	broad.mit.edu	37	13	113893835	113893835	+	Silent	SNP	G	G	T	rs138821614	byFrequency	TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr13:113893835G>T	uc010tjy.1	+	11	1016	c.1005G>T	c.(1003-1005)GCG>GCT	p.A335A	CUL4A_uc010tjx.1_Silent_p.A235A|CUL4A_uc010agu.2_Silent_p.A196A|CUL4A_uc010tjz.1_Silent_p.A14A	NM_001008895	NP_001008895	Q13619	CUL4A_HUMAN	cullin 4A isoform 1	335					cell cycle arrest|DNA repair|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	ubiquitin protein ligase binding			central_nervous_system(2)|skin(1)	3	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.112)			GGCAGCAGGCGCTGCTGCAGC	0.637		NaN											1	0	1.96895e-08	0.00278	2.07232e-08	20	74									
POTEG	404785	broad.mit.edu	37	14	19566047	19566047	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:19566047A>G	uc001vuz.1	+	6	1143	c.1091A>G	c.(1090-1092)CAG>CGG	p.Q364R	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA|uc001vvb.2_Intron	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	364										ovary(1)	1						AAAGAAAAACAGATGCTAAAA	0.229		NaN											0	0	0	0.013537	0	10	135									
TEP1	7011	broad.mit.edu	37	14	20871547	20871547	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:20871547C>G	uc001vxe.2	-	7	1295	c.1255G>C	c.(1255-1257)GAG>CAG	p.E419Q	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.E311Q	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	419	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TTTCTCTGCTCTTCTCTGAGA	0.408		NaN											0	0	0	0.01441	0	65	97									
JUB	84962	broad.mit.edu	37	14	23451348	23451348	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:23451348C>T	uc001whz.2	-	1	504	c.128G>A	c.(127-129)GGA>GAA	p.G43E		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	43	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CTTCCTAGGTCCCCCCAACCC	0.677		NaN											0	0	0	0.010729	0	11	42									
DHRS4L2	317749	broad.mit.edu	37	14	24470602	24470602	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:24470602C>T	uc001wli.3	+	6	671	c.541C>T	c.(541-543)CCT>TCT	p.P181S	DHRS4_uc001wlc.3_Intron|DHRS4L2_uc001wld.3_Intron|DHRS4L2_uc001wle.3_Intron|DHRS4L2_uc001wlg.3_Intron|DHRS4L2_uc001wlh.3_Intron|DHRS4L2_uc010tnt.1_Missense_Mutation_p.P104S|DHRS4L2_uc010alb.2_Missense_Mutation_p.P55S	NM_198083	NP_932349	D5KJA1	D5KJA1_HUMAN	dehydrogenase/reductase (SDR family) member 4	119							binding|oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00962)		GGGCTTCAGTCCTTACAATGT	0.478		NaN											0	0	0	0.009535	0	25	88									
NRL	4901	broad.mit.edu	37	14	24551781	24551781	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:24551781C>T	uc001wlo.2	-	2	408	c.277G>A	c.(277-279)GAA>AAA	p.E93K	NRL_uc001wlp.2_Missense_Mutation_p.E93K|NRL_uc001wlq.2_Missense_Mutation_p.E93K	NM_006177	NP_006168	P54845	NRL_HUMAN	neural retina leucine zipper	93					response to stimulus|transcription from RNA polymerase II promoter|visual perception	nucleus	leucine zipper domain binding|sequence-specific DNA binding				0				GBM - Glioblastoma multiforme(265;0.0181)		ATGGCCTCTTCAGGACTCAGC	0.682		NaN											0	0	0	0.010729	0	12	37									
LTB4R2	56413	broad.mit.edu	37	14	24780363	24780363	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:24780363G>A	uc001woq.1	+	1	2203	c.586G>A	c.(586-588)GAC>AAC	p.D196N	CIDEB_uc001woo.2_5'UTR|CIDEB_uc001wop.2_5'UTR|LTB4R2_uc010alo.2_Missense_Mutation_p.D165N|LTB4R2_uc001wor.2_Missense_Mutation_p.D165N|LTB4R_uc001wos.2_5'Flank|LTB4R_uc010alp.2_5'Flank	NM_019839	NP_062813	Q9NPC1	LT4R2_HUMAN	leukotriene B4 receptor 2	196	Extracellular (Potential).				chemotaxis|negative regulation of adenylate cyclase activity	integral to plasma membrane					0				GBM - Glioblastoma multiforme(265;0.018)		CCTGTGGAGGGACCGCGTATG	0.731		NaN											0	0	0	0.001984	0	6	15									
PRKD1	5587	broad.mit.edu	37	14	30046445	30046445	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:30046445C>T	uc001wqh.2	-	18	2919	c.2738G>A	c.(2737-2739)TGA>TAA	p.*913*		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	913					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		AGATGGAACTCAGAGGATGCT	0.443		NaN											0	0	0	0.010504	0	19	46									
STRN3	29966	broad.mit.edu	37	14	31416386	31416386	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:31416386G>A	uc001wqu.2	-	5	842	c.626C>T	c.(625-627)TCA>TTA	p.S209L	STRN3_uc001wqv.2_Missense_Mutation_p.S209L|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	209					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		ATTTGGTTCTGAATTAGATAG	0.348		NaN											0	0	0	0.005443	0	25	62									
NKX2-8	26257	broad.mit.edu	37	14	37050400	37050400	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:37050400G>A	uc001wtx.2	-	2	619	c.427C>T	c.(427-429)CGC>TGC	p.R143C		NM_014360	NP_055175	O15522	NKX28_HUMAN	NK2 homeobox 8	143	Homeobox.				liver development|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Breast(36;0.143)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.0113)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0171)		CCTGGAGCGCGAGCGCGCTTC	0.701		NaN											0	0	0	0.000602	0	4	6									
MIPOL1	145282	broad.mit.edu	37	14	37739687	37739687	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:37739687C>T	uc001wuc.2	+	7	953	c.450C>T	c.(448-450)CTC>CTT	p.L150L	MIPOL1_uc010amr.2_RNA|MIPOL1_uc001wub.3_Silent_p.L119L|MIPOL1_uc001wud.2_Silent_p.L150L|MIPOL1_uc010ams.2_Silent_p.L150L|MIPOL1_uc001wue.2_Silent_p.L119L|MIPOL1_uc010amt.2_Intron	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	150	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AGCTGGAACTCCAAGAGAAAG	0.333		NaN											0	0	0	0.004482	0	8	15									
FOXA1	3169	broad.mit.edu	37	14	38061866	38061866	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:38061866C>T	uc001wuf.2	-	2	435	c.123G>A	c.(121-123)ATG>ATA	p.M41I	FOXA1_uc010tpz.1_Missense_Mutation_p.M8I	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	41					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TCATGGAGTTCATGGAGCCCA	0.597		NaN											0	0	0	0.006214	0	9	60									
LRFN5	145581	broad.mit.edu	37	14	42356687	42356687	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:42356687C>T	uc001wvm.2	+	3	2057	c.859C>T	c.(859-861)CCT>TCT	p.P287S	LRFN5_uc010ana.2_Missense_Mutation_p.P287S	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	287	Extracellular (Potential).|Ig-like.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GTGTGAGCCTCCTCTCATTAC	0.493		NaN								HNSCC(30;0.082)			0	0	0	0.003163	0	16	56									
KLHL28	54813	broad.mit.edu	37	14	45414370	45414370	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:45414370C>T	uc001wvq.2	-	2	1008	c.762G>A	c.(760-762)TTG>TTA	p.L254L	KLHL28_uc001wvr.2_Silent_p.L254L|KLHL28_uc001wvt.3_Silent_p.L254L	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	254										ovary(1)	1						GGGCTTCATTCAAAAGATGTT	0.398		NaN											0	0	0	0.001168	0	6	30									
C14orf183	196913	broad.mit.edu	37	14	50559295	50559295	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:50559295T>C	uc010tqk.1	-	1	67	c.67A>G	c.(67-69)ATG>GTG	p.M23V		NM_001014830	NP_001014830	Q8WXQ3	CN183_HUMAN	hypothetical protein LOC196913	23											0						CACATTTCCATCCAGATTTCA	0.418		NaN											0	0	0	0.013537	0	11	28									
ARID4A	5926	broad.mit.edu	37	14	58820410	58820410	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:58820410G>A	uc001xdp.2	+	17	1944	c.1690G>A	c.(1690-1692)GAG>AAG	p.E564K	ARID4A_uc001xdo.2_Missense_Mutation_p.E564K|ARID4A_uc001xdq.2_Missense_Mutation_p.E564K|ARID4A_uc010apg.1_Missense_Mutation_p.E242K	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	564					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						CTCTGAAGGAGAGGAAGATGA	0.358		NaN											0	0	0	0.010729	0	11	16									
C14orf39	317761	broad.mit.edu	37	14	60945040	60945040	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:60945040G>A	uc001xez.3	-	5	411	c.301C>T	c.(301-303)CAA>TAA	p.Q101*	C14orf39_uc010apo.2_Intron	NM_174978	NP_777638	Q08AQ4	Q08AQ4_HUMAN	hypothetical protein LOC317761	101										ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		ACAGTTCCTTGATAAACAGTA	0.289		NaN											0	0	0	0.003163	0	12	27									
HSPA2	3306	broad.mit.edu	37	14	65008648	65008648	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:65008648G>C	uc001xhj.2	+	2	1157	c.1081G>C	c.(1081-1083)GAG>CAG	p.E361Q	HSPA2_uc001xhk.3_Missense_Mutation_p.E361Q	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	361					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CAACGGCAAGGAGCTGAACAA	0.602		NaN											0	0	0	0.003163	0	15	42									
MPP5	64398	broad.mit.edu	37	14	67768707	67768707	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:67768707G>A	uc001xjc.2	+	6	1139	c.673G>A	c.(673-675)GAT>AAT	p.D225N	MPP5_uc001xjd.2_Missense_Mutation_p.D191N|ATP6V1D_uc001xje.2_Intron	NM_022474	NP_071919	Q8N3R9	MPP5_HUMAN	membrane protein, palmitoylated 5	225	Interaction with LIN7C (By similarity).|L27 2.				tight junction assembly	cytoplasm|endomembrane system|tight junction	protein domain specific binding			ovary(1)	1				all cancers(60;0.000388)|OV - Ovarian serous cystadenocarcinoma(108;0.00762)|BRCA - Breast invasive adenocarcinoma(234;0.0106)		ACTGGCCCACGATAAGGTTGC	0.383		NaN											0	0	0	0.00245	0	14	31									
SLC8A3	6547	broad.mit.edu	37	14	70513028	70513028	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:70513028C>G	uc001xly.2	-	8	3174	c.2420G>C	c.(2419-2421)AGC>ACC	p.S807T	SLC8A3_uc001xlu.2_Missense_Mutation_p.S164T|SLC8A3_uc001xlv.2_Missense_Mutation_p.S178T|SLC8A3_uc001xlw.2_Missense_Mutation_p.S804T|SLC8A3_uc001xlx.2_Missense_Mutation_p.S805T|SLC8A3_uc001xlz.2_Missense_Mutation_p.S801T|SLC8A3_uc010ara.2_RNA|SLC8A3_uc001xma.2_3'UTR	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	807	Alpha-2.|Extracellular (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGCAGCTTTGCTGGCAAACGT	0.557		NaN									OREG0022773	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	20									
SLC8A3	6547	broad.mit.edu	37	14	70634195	70634195	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:70634195C>T	uc001xly.2	-	2	1699	c.945G>A	c.(943-945)GAG>GAA	p.E315E	SLC8A3_uc001xlw.2_Silent_p.E315E|SLC8A3_uc001xlx.2_Silent_p.E315E|SLC8A3_uc001xlz.2_Silent_p.E315E|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	315	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TCCGGATCATCTCTCTGCGGG	0.483		NaN											0	0	0	0.003163	0	14	44									
TTC9	23508	broad.mit.edu	37	14	71134362	71134362	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:71134362A>C	uc001xmi.2	+	2	831	c.488A>C	c.(487-489)AAC>ACC	p.N163T		NM_015351	NP_056166	Q92623	TTC9A_HUMAN	tetratricopeptide repeat domain 9	163	TPR 3.						binding				0				all cancers(60;0.00545)|BRCA - Breast invasive adenocarcinoma(234;0.00747)|OV - Ovarian serous cystadenocarcinoma(108;0.0538)		GAAGGGGAGAACTTCAAGGCC	0.507		NaN											0	0	0	0.004007	0	17	48									
TC2N	123036	broad.mit.edu	37	14	92258883	92258883	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:92258883G>A	uc001xzu.3	-	9	1066	c.875C>T	c.(874-876)ACG>ATG	p.T292M	TC2N_uc001xzt.3_Missense_Mutation_p.T292M|TC2N_uc010auc.2_Intron|TC2N_uc001xzv.3_Missense_Mutation_p.T292M	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	292						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		AAATACAAACGTTTCCATAAA	0.254		NaN											0	0	0	0.001984	0	6	24									
TRIP11	9321	broad.mit.edu	37	14	92466417	92466417	+	Silent	SNP	T	T	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:92466417T>A	uc001xzy.2	-	12	5381	c.4593A>T	c.(4591-4593)GCA>GCT	p.A1531A	TRIP11_uc010auf.1_Silent_p.A1267A	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	1531	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTGATTTAACTGCATTTAAAA	0.353		NaN	T	PDGFRB	AML								0	0	0	0.00308	0	7	25									
GOLGA5	9950	broad.mit.edu	37	14	93299524	93299524	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:93299524C>A	uc001yaz.1	+	10	1959	c.1777C>A	c.(1777-1779)CAG>AAG	p.Q593K	GOLGA5_uc001yba.1_5'UTR	NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	593	Cytoplasmic (Potential).|Potential.				Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		TCGACTCCATCAGCTAACAGA	0.413		NaN	T	RET	papillary thyroid								1	0	3.62473e-10	0.012319	3.8622e-10	22	50									
DYNC1H1	1778	broad.mit.edu	37	14	102446773	102446773	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:102446773C>A	uc001yks.2	+	5	1011	c.847C>A	c.(847-849)CGT>AGT	p.R283S		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	283	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						AAACTTGGAACGTGCGTTATA	0.468		NaN											1	0	0.00024832	0.009096	0.000257894	4	35									
ZNF839	55778	broad.mit.edu	37	14	102805205	102805205	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:102805205C>G	uc001ylo.2	+	6	1714	c.1364C>G	c.(1363-1365)CCA>CGA	p.P455R	ZNF839_uc010awk.1_Missense_Mutation_p.P571R|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Missense_Mutation_p.P455R|ZNF839_uc001ylr.2_Missense_Mutation_p.P380R|ZNF839_uc001yls.2_Missense_Mutation_p.P70R|ZNF839_uc001ylt.2_Missense_Mutation_p.P45R	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	455						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GAAATACACCCAGACAACCTT	0.502		NaN											0	0	0	0.001168	0	5	31									
TRMT61A	115708	broad.mit.edu	37	14	103996324	103996324	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:103996324C>G	uc001yng.2	+	2	128	c.9C>G	c.(7-9)TTC>TTG	p.F3L	TRMT61A_uc010aws.2_Intron	NM_152307	NP_689520	Q96FX7	TRM61_HUMAN	tRNA(m1A58)-methyltransferase subunit TRM61	3						nucleus	protein binding|tRNA (adenine-N1-)-methyltransferase activity				0						CCATGAGCTTCGTGGCATACG	0.617		NaN											0	0	0	0.000602	0	3	12									
AHNAK2	113146	broad.mit.edu	37	14	105407270	105407270	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr14:105407270A>G	uc010axc.1	-	7	14638	c.14518T>C	c.(14518-14520)TCT>CCT	p.S4840P	AHNAK2_uc001ypx.2_Missense_Mutation_p.S4740P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4840						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCAGCTTGAGATGTTGGAACT	0.463		NaN											0	0	0	0.009096	0	4	13									
C15orf2	23742	broad.mit.edu	37	15	24922847	24922847	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:24922847G>A	uc001ywo.2	+	1	2307	c.1833G>A	c.(1831-1833)CAG>CAA	p.Q611Q		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	611					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GTGCAGAGCAGAGGCACCCGG	0.463		NaN											0	0	0	0.013537	0	12	49									
NDNL2	56160	broad.mit.edu	37	15	29561649	29561649	+	Silent	SNP	C	C	T	rs138846663		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:29561649C>T	uc001zco.2	-	1	369	c.261G>A	c.(259-261)CTG>CTA	p.L87L	FAM189A1_uc010azk.1_Intron	NM_138704	NP_619649	Q96MG7	MAGG1_HUMAN	necdin-like 2	87	MAGE.				regulation of growth	cytoplasm|nucleus					0		all_lung(180;4.69e-11)|Breast(32;0.0013)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00736)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		CGGACACTTTCAGCTCCAGCT	0.478		NaN									OREG0032044	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	0	0	0	0.013537	0	11	53									
TRPM1	4308	broad.mit.edu	37	15	31360175	31360175	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:31360175T>C	uc001zfm.2	-	4	462	c.334A>G	c.(334-336)ATG>GTG	p.M112V	TRPM1_uc010azy.2_Missense_Mutation_p.M25V|TRPM1_uc001zfl.2_RNA|uc010ubm.1_5'Flank|MIR211_hsa-mir-211|MI0000287_5'Flank|uc010ubn.1_5'Flank	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	112	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTGGGCTGCATCTCAAAGTTC	0.537		NaN											0	0	0	0.014323	0	22	81									
EIF2AK4	440275	broad.mit.edu	37	15	40241433	40241433	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:40241433G>A	uc001zkm.1	+	4	527	c.477G>A	c.(475-477)CAG>CAA	p.Q159Q	EIF2AK4_uc001zkl.2_Silent_p.Q159Q	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	159					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AGGAGCAGCAGAGGCTGTTGG	0.542		NaN											0	0	0	0.008291	0	10	33									
RHOV	171177	broad.mit.edu	37	15	41165414	41165414	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:41165414C>T	uc001znd.2	-	3	703	c.553G>A	c.(553-555)GAG>AAG	p.E185K		NM_133639	NP_598378	Q96L33	RHOV_HUMAN	ras homolog gene family, member V	185					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding				0		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCTGAGCACTCAAGGTAGCAG	0.577		NaN											0	0	0	0.00632	0	27	71									
RHOV	171177	broad.mit.edu	37	15	41165937	41165937	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:41165937T>A	uc001znd.2	-	2	362	c.212A>T	c.(211-213)CAA>CTA	p.Q71L		NM_133639	NP_598378	Q96L33	RHOV_HUMAN	ras homolog gene family, member V	71					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome membrane|plasma membrane	GTP binding|metal ion binding				0		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.58e-05)|COAD - Colon adenocarcinoma(120;0.149)|BRCA - Breast invasive adenocarcinoma(123;0.163)		CACCAGGACTTGCACTGCAGG	0.697		NaN											0	0	0	0.00333	0	23	91									
INO80	54617	broad.mit.edu	37	15	41337108	41337108	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:41337108C>G	uc001zni.2	-	24	3114	c.2901G>C	c.(2899-2901)TTG>TTC	p.L967F	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	967	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TTACCTTTAACAAAGGGCAGC	0.388		NaN											0	0	0	0.001984	0	7	29									
INO80	54617	broad.mit.edu	37	15	41337203	41337203	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:41337203C>T	uc001zni.2	-	24	3019	c.2806G>A	c.(2806-2808)GAA>AAA	p.E936K	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	936	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						CTCTCCCCTTCTGGCGCTCCC	0.493		NaN											0	0	0	0.00499	0	14	49									
WDR76	79968	broad.mit.edu	37	15	44127283	44127283	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:44127283G>A	uc001zti.1	+	3	510	c.487G>A	c.(487-489)GAA>AAA	p.E163K		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	163											0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		GTCACCCTACGAAAGGAAGAG	0.353		NaN											0	0	0	0.00308	0	8	28									
COPS2	9318	broad.mit.edu	37	15	49437268	49437268	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:49437268G>C	uc001zxf.2	-	2	141	c.62C>G	c.(61-63)TCT>TGT	p.S21C	COPS2_uc001zxh.2_Missense_Mutation_p.S21C|COPS2_uc010ufa.1_Intron	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	21					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		ACTATCTTCAGAGTATTCCTG	0.348		NaN											0	0	0	0.003163	0	14	41									
USP8	9101	broad.mit.edu	37	15	50776527	50776527	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:50776527G>A	uc001zym.3	+	13	2359	c.1859G>A	c.(1858-1860)AGA>AAA	p.R620K	USP8_uc001zyl.3_Missense_Mutation_p.R620K|USP8_uc001zyn.3_Missense_Mutation_p.R620K|USP8_uc010ufh.1_Intron	NM_001128611	NP_001122083	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	620					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)|central_nervous_system(1)	2				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GGAACTTTTAGAGAGGATACA	0.299		NaN											0	0	0	0.010729	0	9	49									
DMXL2	23312	broad.mit.edu	37	15	51791720	51791720	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:51791720C>G	uc002abf.2	-	18	3926	c.3701G>C	c.(3700-3702)AGA>ACA	p.R1234T	DMXL2_uc010ufy.1_Missense_Mutation_p.R1234T|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1234						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GTCTATAGATCTAAGAAGAAC	0.428		NaN											0	0	0	0.003163	0	16	40									
DMXL2	23312	broad.mit.edu	37	15	51795035	51795035	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:51795035G>A	uc002abf.2	-	17	3185	c.2960C>T	c.(2959-2961)TCA>TTA	p.S987L	DMXL2_uc010ufy.1_Missense_Mutation_p.S987L|DMXL2_uc010bfa.2_Intron	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	987						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TACTTCAACTGATTCTGGGAG	0.418		NaN											0	0	0	0.006214	0	9	46									
RPL4	6124	broad.mit.edu	37	15	66792429	66792429	+	Missense_Mutation	SNP	T	T	C	rs139349583		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:66792429T>C	uc002apv.2	-	9	1059	c.1003A>G	c.(1003-1005)ATG>GTG	p.M335V	SNAPC5_uc002apu.1_5'Flank|RPL4_uc010bhr.2_Missense_Mutation_p.M241V|RPL4_uc002apw.2_Missense_Mutation_p.M241V|RPL4_uc002apx.2_Missense_Mutation_p.M241V	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	335					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						TTCCGGCGCATGGTCTTTGCA	0.328		NaN											0	0	0	0.010729	0	11	31									
ANP32A	8125	broad.mit.edu	37	15	69080146	69080146	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:69080146G>A	uc002arl.2	-	2	338	c.167C>T	c.(166-168)TCA>TTA	p.S56L		NM_006305	NP_006296	P39687	AN32A_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32	56	LRR 2.				intracellular signal transduction|mRNA metabolic process|nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleoplasm|perinuclear region of cytoplasm	protein binding				0						GTTTGCGATTGAGGTGAGGCC	0.468		NaN											0	0	0	0.013537	0	13	56									
NOX5	79400	broad.mit.edu	37	15	69327745	69327745	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:69327745C>T	uc002ars.1	+	6	927	c.907C>T	c.(907-909)CAA>TAA	p.Q303*	NOX5_uc002arp.1_Nonsense_Mutation_p.Q285*|NOX5_uc002arq.1_Nonsense_Mutation_p.Q257*|NOX5_uc010bid.1_Nonsense_Mutation_p.Q268*|NOX5_uc002arr.1_Nonsense_Mutation_p.Q275*|NOX5_uc010bie.1_Nonsense_Mutation_p.Q103*|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	303	Ferric oxidoreductase.|Cytoplasmic (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						GTGGCTGGCTCAAGTCCTACC	0.612		NaN											0	0	0	0.010729	0	12	34									
THAP10	56906	broad.mit.edu	37	15	71184460	71184460	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:71184460G>C	uc002asv.2	-	1	294	c.152C>G	c.(151-153)TCG>TGG	p.S51W	LRRC49_uc002asu.2_Intron|LRRC49_uc002asw.2_5'Flank|LRRC49_uc002asx.2_5'Flank|LRRC49_uc010ukf.1_5'Flank	NM_020147	NP_064532	Q9P2Z0	THA10_HUMAN	THAP domain containing 10	51	THAP-type.						DNA binding|metal ion binding			ovary(1)|skin(1)	2						GCAGATGACCGAGCGGTCATT	0.637		NaN											0	0	0	0.00308	0	6	31									
CYP11A1	1583	broad.mit.edu	37	15	74640360	74640360	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:74640360G>A	uc002axt.2	-	2	461	c.306C>T	c.(304-306)ATC>ATT	p.I102I	CYP11A1_uc002axs.2_5'UTR|CYP11A1_uc010bjm.1_Intron|CYP11A1_uc010bjn.1_RNA|CYP11A1_uc010bjo.1_Silent_p.I102I|CYP11A1_uc010ulj.1_5'UTR|CYP11A1_uc010bjq.2_Silent_p.I102I	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	102					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	CTTCAGGGTCGATGACATAAA	0.443		NaN											0	0	0	0.008871	0	15	31									
SGK269	79834	broad.mit.edu	37	15	77406944	77406944	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:77406944T>G	uc002bcm.2	-	6	5103	c.4795A>C	c.(4795-4797)ATC>CTC	p.I1599L		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1599	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		ATCTCATAGATGAGGATGCCT	0.547		NaN											0	0	0	0.003163	0	16	28									
C15orf26	161502	broad.mit.edu	37	15	81440822	81440822	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:81440822C>G	uc002bgb.2	+	7	881	c.854C>G	c.(853-855)CCC>CGC	p.P285R		NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	285											0						CCCAAACCACCCACAGAGGAC	0.547		NaN											0	0	0	0.008291	0	9	50									
TMC3	342125	broad.mit.edu	37	15	81636366	81636366	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:81636366G>A	uc002bgo.1	-	14	1539	c.1539C>T	c.(1537-1539)ATC>ATT	p.I513I	TMC3_uc010blr.1_RNA|TMC3_uc002bgp.2_Silent_p.I513I	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	513	Helical; (Potential).					integral to membrane				ovary(1)|liver(1)	2						GCATGTCAATGATGGAGAGCT	0.537		NaN											0	0	0	0.004482	0	8	32									
AP3B2	8120	broad.mit.edu	37	15	83357579	83357579	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:83357579T>C	uc010uoh.1	-	4	446	c.269A>G	c.(268-270)AAG>AGG	p.K90R	AP3B2_uc010uoi.1_Missense_Mutation_p.K90R|AP3B2_uc010uoj.1_Intron|AP3B2_uc010uok.1_Missense_Mutation_p.K90R	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	90					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GACAAGCTTCTTCACCTTGGG	0.597		NaN											0	0	0	0.009096	0	3	6									
ALPK3	57538	broad.mit.edu	37	15	85402570	85402570	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:85402570C>T	uc002ble.2	+	7	4687	c.4520C>T	c.(4519-4521)TCA>TTA	p.S1507L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1507	Ig-like 2.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTTAGTGACTCAGTCTTGACA	0.572		NaN											0	0	0	0.009096	0	4	25									
AKAP13	11214	broad.mit.edu	37	15	86087161	86087161	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:86087161C>T	uc002blv.1	+	5	807	c.637C>T	c.(637-639)CAC>TAC	p.H213Y	AKAP13_uc002blt.1_Missense_Mutation_p.H213Y|AKAP13_uc002blu.1_Missense_Mutation_p.H213Y	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	213					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						GCGAGGCTATCACAAGCTGCA	0.587		NaN											0	0	0	0.00245	0	12	40									
FANCI	55215	broad.mit.edu	37	15	89848417	89848417	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:89848417A>C	uc010bnp.1	+	29	3220	c.3130A>C	c.(3130-3132)ATT>CTT	p.I1044L	FANCI_uc002bnm.1_Missense_Mutation_p.I984L|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.I805L|FANCI_uc002bnq.1_Missense_Mutation_p.I457L	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1044					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					GAGTCCTGTCATTCTGCTGCG	0.453		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.005443	0	24	58									
IQGAP1	8826	broad.mit.edu	37	15	90976974	90976974	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr15:90976974T>C	uc002bpl.1	+	5	515	c.414T>C	c.(412-414)GAT>GAC	p.D138D		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	138	CH.				energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			AAACTACAGATATCTATGATC	0.338		NaN											0	0	0	0.00333	0	22	62									
LUC7L	55692	broad.mit.edu	37	16	239316	239316	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:239316T>C	uc002cgc.1	-	10	1108	c.997A>G	c.(997-999)AGA>GGA	p.R333G	LUC7L_uc002cga.1_3'UTR|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_3'UTR|LUC7L_uc002cgb.1_Missense_Mutation_p.R247G	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	333	Arg/Ser-rich.						metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				GACTCCTCTCTGGATGCCCGC	0.647		NaN											0	0	0	0.01441	0	50	30									
IFT140	9742	broad.mit.edu	37	16	1576661	1576661	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:1576661C>G	uc002cmb.2	-	20	2898	c.2536G>C	c.(2536-2538)GAG>CAG	p.E846Q	IFT140_uc002clz.2_Intron|TMEM204_uc002cmc.2_5'Flank	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	846										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				ACGCGGGCCTCTAGCTCCGGC	0.741		NaN											0	0	0	0.001984	0	5	10									
CASKIN1	57524	broad.mit.edu	37	16	2236758	2236758	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:2236758C>A	uc010bsg.1	-	10	1030	c.998G>T	c.(997-999)CGG>CTG	p.R333L		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	333	SH3.				signal transduction	cytoplasm				skin(2)	2						GTAGCCCACCCGGTCATTGCC	0.677		NaN											1	0	6.94344e-10	0.006122	7.3892e-10	19	14									
TMEM159	57146	broad.mit.edu	37	16	21172532	21172532	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:21172532C>T	uc002dif.3	+	2	390	c.29C>T	c.(28-30)TCA>TTA	p.S10L	DNAH3_uc010vbe.1_5'Flank|TMEM159_uc002dig.3_RNA|TMEM159_uc010vbf.1_Missense_Mutation_p.S10L|TMEM159_uc002dih.3_Missense_Mutation_p.S10L	NM_020422	NP_065155	Q96B96	TM159_HUMAN	transmembrane protein 159	10						integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(48;0.0972)		CAGAGTATCTCAAGGGACTTG	0.438		NaN											0	0	0	0.005443	0	24	52									
ARHGAP17	55114	broad.mit.edu	37	16	24963676	24963676	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:24963676T>C	uc002dnb.2	-	12	1073	c.980A>G	c.(979-981)TAT>TGT	p.Y327C	ARHGAP17_uc002dna.2_Missense_Mutation_p.Y54C|ARHGAP17_uc002dnc.2_Missense_Mutation_p.Y327C|ARHGAP17_uc010vcf.1_Missense_Mutation_p.Y148C|ARHGAP17_uc002dnf.2_Missense_Mutation_p.Y235C	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	327	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		TTCCCGTAAATAGGATTTTAA	0.333		NaN											0	0	0	0.003163	0	13	24									
IL4R	3566	broad.mit.edu	37	16	27373925	27373925	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:27373925G>A	uc002don.2	+	11	1494	c.1252G>A	c.(1252-1254)GAG>AAG	p.E418K	IL4R_uc002dop.3_Missense_Mutation_p.E403K|IL4R_uc010bxy.2_Missense_Mutation_p.E418K|IL4R_uc002doo.2_Missense_Mutation_p.E258K	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	418	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						GCTCGGAGAGGAGAATGGGGG	0.597		NaN											0	0	0	0.010729	0	10	50									
SULT1A2	6799	broad.mit.edu	37	16	28603636	28603636	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:28603636G>A	uc002dqg.1	-	7	1074	c.723C>T	c.(721-723)ACC>ACT	p.T241T	uc010vct.1_Intron|SULT1A2_uc002dqh.1_Silent_p.T241T	NM_177528	NP_803564	P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A,	241					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						GGCGGACGGTGGTGTAGTTGG	0.592		NaN											0	0	0	0.005443	0	26	121									
PRRT2	112476	broad.mit.edu	37	16	29824989	29824989	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:29824989C>T	uc002due.3	+	2	915	c.614C>T	c.(613-615)TCA>TTA	p.S205L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duc.1_5'Flank|PRRT2_uc002dud.2_Missense_Mutation_p.S205L|PRRT2_uc002duf.1_Missense_Mutation_p.S205L|C16orf53_uc002dug.3_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	205	Extracellular (Potential).|Pro-rich.				response to biotic stimulus	integral to membrane					0						TCACCACCCTCAAAAAAATCC	0.612		NaN											0	0	0	0.00308	0	7	8									
PRSS53	339105	broad.mit.edu	37	16	31098143	31098143	+	Missense_Mutation	SNP	C	C	T	rs138969193	by1000genomes	TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:31098143C>T	uc002eaq.2	-	4	319	c.319G>A	c.(319-321)GAA>AAA	p.E107K	PRSS53_uc002ear.2_5'UTR	NM_001039503	NP_001034592	Q2L4Q9	PRS53_HUMAN	polyserase 3 precursor	107	Peptidase S1 1.				proteolysis	extracellular region	serine-type endopeptidase activity				0						CCCACCTCTTCGGCCCCAGGG	0.642		NaN											0	0	0	0.008291	0	11	56									
ITGAM	3684	broad.mit.edu	37	16	31341893	31341893	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:31341893G>A	uc002ebq.2	+	28	3341	c.3243G>A	c.(3241-3243)CTG>CTA	p.L1081L	ITGAM_uc002ebr.2_Silent_p.L1082L|ITGAM_uc010can.2_Silent_p.L487L	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	1081	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						TGTTCACCCTGCTGCCGGGAC	0.592		NaN											0	0	0	0.00308	0	7	14									
ABCC12	94160	broad.mit.edu	37	16	48180326	48180326	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:48180326C>T	uc002efc.1	-	1	356	c.10G>A	c.(10-12)GAA>AAA	p.E4K	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Missense_Mutation_p.E4K|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	4						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TAGGGTCCTTCACCCACCATC	0.552		NaN											0	0	0	0.004482	0	8	55									
ADCY7	113	broad.mit.edu	37	16	50332877	50332877	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:50332877C>T	uc002egd.1	+	7	1279	c.1011C>T	c.(1009-1011)CCC>CCT	p.P337P	ADCY7_uc002egb.1_Silent_p.P337P|ADCY7_uc002egc.1_Silent_p.P337P	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	337	Cytoplasmic (Potential).|Guanylate cyclase 1.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CGGGCCTGCCCGTGTCGCTGC	0.637		NaN											0	0	0	0.00632	0	28	39									
BRD7	29117	broad.mit.edu	37	16	50359717	50359717	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:50359717C>T	uc002egf.1	-	12	1340	c.1273G>A	c.(1273-1275)GAT>AAT	p.D425N	BRD7_uc002ege.1_Missense_Mutation_p.D425N	NM_013263	NP_037395	Q9NPI1	BRD7_HUMAN	bromodomain containing 7	425					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding				0		all_cancers(37;0.0127)				AAATCAGAATCATCCTTGCTG	0.338		NaN											0	0	0	0.00308	0	8	32									
CNGB1	1258	broad.mit.edu	37	16	57918175	57918175	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:57918175C>T	uc002emt.2	-	33	3714	c.3649G>A	c.(3649-3651)GAG>AAG	p.E1217K	CNGB1_uc010cdh.2_Missense_Mutation_p.E1211K	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	1217	Cytoplasmic (Potential).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						TCTTCGGGCTCGGCCGGCCCC	0.726		NaN											0	0	0	0.003271	0	34	28									
CTCF	10664	broad.mit.edu	37	16	67650746	67650746	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:67650746T>C	uc002etl.2	+	5	1341	c.1051T>C	c.(1051-1053)TTC>CTC	p.F351L	CTCF_uc010cek.2_Missense_Mutation_p.F23L	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	351	C2H2-type 4.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CGAGAAGCCATTCAAGTGTTC	0.468		NaN											0	0	0	0.013726	0	31	143									
CENPT	80152	broad.mit.edu	37	16	67865747	67865747	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:67865747G>C	uc002eun.3	-	8	982	c.433C>G	c.(433-435)CCA>GCA	p.P145A	CENPT_uc002eum.3_Missense_Mutation_p.P145A|CENPT_uc010vkc.1_5'UTR|CENPT_uc010vkd.1_Intron|CENPT_uc010vke.1_Missense_Mutation_p.P42A	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	145					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		AGCAGACCTGGAGCCAGGGTT	0.582		NaN											0	0	0	0.010729	0	12	31									
NIP7	51388	broad.mit.edu	37	16	69375197	69375197	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:69375197G>A	uc002exa.2	+	4	584	c.397G>A	c.(397-399)GTG>ATG	p.V133M	COG8_uc002ewy.2_5'Flank|COG8_uc002ewz.3_5'Flank|NIP7_uc002exb.2_Intron	NM_016101	NP_057185	Q9Y221	NIP7_HUMAN	nuclear import 7	133	PUA.				ribosome assembly	nucleolus	protein binding|RNA binding			breast(1)	1		Ovarian(137;0.101)				GGGCGTGGTGGTGTACTCCAT	0.468		NaN											0	0	0	0.001855	0	12	23									
TERF2	7014	broad.mit.edu	37	16	69419544	69419544	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:69419544G>C	uc002exd.2	-	1	330	c.205C>G	c.(205-207)CGG>GGG	p.R69G	TERF2_uc002exe.2_Missense_Mutation_p.R69G	NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	69	TRFH dimerization.				age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)				CGGCTACCCCGAAAGGCCCGC	0.582		NaN											0	0	0	0.009096	0	3	23									
USP10	9100	broad.mit.edu	37	16	84778354	84778354	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:84778354A>G	uc002fii.2	+	4	409	c.267A>G	c.(265-267)GAA>GAG	p.E89E	USP10_uc010voe.1_Silent_p.E93E|USP10_uc010vof.1_Intron|USP10_uc002fij.2_5'UTR	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	89	Interaction with p53/TP53.				DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						AGGCCCCTGAATTTATTCTCG	0.493		NaN											0	0	0	0.013726	0	31	47									
APRT	353	broad.mit.edu	37	16	88877971	88877971	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr16:88877971G>A	uc002flv.2	-	2	209	c.174C>T	c.(172-174)ATC>ATT	p.I58I	APRT_uc002flw.2_Silent_p.I58I	NM_000485	NP_000476	P07741	APT_HUMAN	adenine phosphoribosyltransferase isoform a	58					purine ribonucleoside salvage	cytosol|nucleus	adenine phosphoribosyltransferase activity|AMP binding|protein binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0477)	Adenine(DB00173)|Adenosine monophosphate(DB00131)	CGATGTAGTCGATGCGGCCCC	0.721		NaN											0	0	0	0.001168	0	4	7									
MED11	400569	broad.mit.edu	37	17	4635097	4635097	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:4635097G>A	uc002fyp.2	+	2	174	c.112G>A	c.(112-114)GAA>AAA	p.E38K		NM_001001683	NP_001001683	Q9P086	MED11_HUMAN	mediator complex subunit 11	38					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex	protein binding				0						ATTGTCCAAGGAAAAAACTAA	0.617		NaN									OREG0024104	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	12	18									
SLC16A13	201232	broad.mit.edu	37	17	6941694	6941694	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:6941694C>T	uc002geh.2	+	3	875	c.567C>T	c.(565-567)CTC>CTT	p.L189L		NM_201566	NP_963860	Q7RTY0	MOT13_HUMAN	monocarboxylate transporter 13	189	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(1)|skin(1)	2						GTGCTCTCCTCCGCCCACCCT	0.657		NaN											0	0	0	0.012213	0	32	44									
SLC2A4	6517	broad.mit.edu	37	17	7187317	7187317	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:7187317T>C	uc002gfp.2	+	5	673	c.473T>C	c.(472-474)ATG>ACG	p.M158T	SLC2A4_uc002gfo.2_Missense_Mutation_p.M158T|SLC2A4_uc010cmd.2_RNA	NM_001042	NP_001033	P14672	GTR4_HUMAN	glucose transporter 4	158	Helical; Name=4; (Potential).				carbohydrate metabolic process|glucose homeostasis|glucose import	external side of plasma membrane|integral to plasma membrane|perinuclear region of cytoplasm	D-glucose transmembrane transporter activity|protein binding				0						CTGGTGCCCATGTACGTGGGG	0.612		NaN											0	0	0	0.006214	0	10	14									
C17orf74	201243	broad.mit.edu	37	17	7329872	7329872	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:7329872G>T	uc002ggw.2	+	3	635	c.562G>T	c.(562-564)GAG>TAG	p.E188*	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	188						integral to membrane					0		Prostate(122;0.157)				CCTGGAGGAGGAGGACAACCT	0.592		NaN											1	0	9.72345e-25	0.01441	1.05429e-24	54	69									
TP53	7157	broad.mit.edu	37	17	7578269	7578269	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:7578269G>A	uc002gim.2	-	6	774	c.580C>T	c.(580-582)CTT>TTT	p.L194F	TP53_uc002gig.1_Missense_Mutation_p.L194F|TP53_uc002gih.2_Missense_Mutation_p.L194F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L62F|TP53_uc010cng.1_Missense_Mutation_p.L62F|TP53_uc002gii.1_Missense_Mutation_p.L62F|TP53_uc010cnh.1_Missense_Mutation_p.L194F|TP53_uc010cni.1_Missense_Mutation_p.L194F|TP53_uc002gij.2_Missense_Mutation_p.L194F|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.L101F|TP53_uc002gio.2_Missense_Mutation_p.L62F|TP53_uc010vug.1_Missense_Mutation_p.L155F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	194	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> H (in sporadic cancers; somatic mutation).|L -> R (in sporadic cancers; somatic mutation).|L -> I (in sporadic cancers; somatic mutation).|L -> F (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L194R(31)|p.L194F(16)|p.L194P(8)|p.0?(7)|p.L194H(5)|p.L194L(4)|p.A189_V197delAPPQHLIRV(4)|p.P191fs*53(2)|p.L194fs*15(2)|p.K164_P219del(1)|p.L194fs*14(1)|p.A189fs*53(1)|p.L194V(1)|p.L194I(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.L194fs*52(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACTCGGATAAGATGCTGAGGA	0.552		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00245	0	13	18									
TMEM220	388335	broad.mit.edu	37	17	10628432	10628432	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:10628432A>G	uc002gmx.2	-	4	661	c.183T>C	c.(181-183)AGT>AGC	p.S61S	TMEM220_uc002gmy.2_Silent_p.S51S	NM_001004313	NP_001004313	Q6QAJ8	TM220_HUMAN	transmembrane protein 220	61						integral to membrane					0						TTGCAGAGATACTTTTCCAAA	0.388		NaN											0	0	0	0.013537	0	12	16									
SREBF1	6720	broad.mit.edu	37	17	17716923	17716923	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:17716923A>G	uc002gru.1	-	17	3256	c.3062T>C	c.(3061-3063)CTG>CCG	p.L1021P	SREBF1_uc002gro.3_5'Flank|SREBF1_uc002grp.1_Missense_Mutation_p.L640P|SREBF1_uc002grq.1_Missense_Mutation_p.L540P|SREBF1_uc002grr.1_Missense_Mutation_p.L767P|SREBF1_uc002grs.1_Missense_Mutation_p.L997P|SREBF1_uc002grt.1_Missense_Mutation_p.L1051P	NM_004176	NP_004167	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription	1021	Cytoplasmic (Potential).				cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			skin(1)	1						CAGCCGCCTCAGGCTGCTCAG	0.711		NaN											0	0	0	0.004672	0	2	5									
ULK2	9706	broad.mit.edu	37	17	19705182	19705182	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:19705182C>G	uc002gwm.3	-	16	1858	c.1349G>C	c.(1348-1350)GGA>GCA	p.G450A	ULK2_uc002gwn.2_Missense_Mutation_p.G450A	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	450					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GGAGCATGATCCCGGCCGGAG	0.507		NaN											0	0	0	0.01441	0	73	83									
MYO18A	399687	broad.mit.edu	37	17	27493277	27493277	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:27493277T>C	uc002hdt.1	-	2	840	c.682A>G	c.(682-684)ACT>GCT	p.T228A	MYO18A_uc010csa.1_Missense_Mutation_p.T228A|MYO18A_uc002hdu.1_Missense_Mutation_p.T228A	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	228	PDZ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			AAGTCTCCAGTGGGCCGTCGT	0.667		NaN											0	0	0	0.013726	0	32	56									
NF1	4763	broad.mit.edu	37	17	29679408	29679408	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:29679408C>T	uc002hgg.2	+	51	7924	c.7591C>T	c.(7591-7593)CAG>TAG	p.Q2531*	NF1_uc002hgh.2_Nonsense_Mutation_p.Q2510*|NF1_uc010cso.2_Nonsense_Mutation_p.Q719*|NF1_uc010wbt.1_Intron|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2531					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GCAACCTTCTCAGGCCAACAC	0.388		NaN	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			0	0	0	0.004482	0	8	29									
LIG3	3980	broad.mit.edu	37	17	33325294	33325294	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:33325294G>A	uc002hik.1	+	13	2076	c.1968G>A	c.(1966-1968)GGG>GGA	p.G656G	LIG3_uc002hij.2_Silent_p.G656G	NM_013975	NP_039269	P49916	DNLI3_HUMAN	ligase III, DNA, ATP-dependent isoform alpha	656					base-excision repair|cell division|DNA ligation involved in DNA repair|DNA replication|reciprocal meiotic recombination|spermatogenesis	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|protein binding|zinc ion binding			skin(3)|lung(2)|ovary(2)|large_intestine(1)|pancreas(1)	9		Ovarian(249;0.17)			Bleomycin(DB00290)	GATTGGAGGGGCTGGTGCTGA	0.562		NaN						Other_BER_factors			OREG0024326	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	13	42									
DHRS11	79154	broad.mit.edu	37	17	34956152	34956152	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:34956152A>G	uc002hnd.2	+	5	849	c.635A>G	c.(634-636)AAG>AGG	p.K212R	MRM1_uc002hne.2_5'Flank|MRM1_uc002hnf.2_5'Flank	NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	212						extracellular region	binding|oxidoreductase activity				0						CTCCACGACAAGGACCCTGAG	0.572		NaN											0	0	0	0.00278	0	22	41									
RARA	5914	broad.mit.edu	37	17	38510642	38510642	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:38510642A>G	uc002huk.1	+	7	1351	c.896A>G	c.(895-897)AAC>AGC	p.N299S	RARA_uc002hul.3_Missense_Mutation_p.N299S|RARA_uc010wfe.1_Missense_Mutation_p.N202S|RARA_uc002hun.1_Missense_Mutation_p.N294S	NM_000964	NP_000955	P10276	RARA_HUMAN	retinoic acid receptor, alpha isoform 1	299	Ligand-binding.				apoptotic cell clearance|cellular response to estrogen stimulus|cellular response to retinoic acid|estrogen receptor signaling pathway|negative regulation of granulocyte differentiation|negative regulation of interferon-gamma production|negative regulation of tumor necrosis factor production|positive regulation of binding|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	cytoplasm|nucleoplasm	chromatin DNA binding|enzyme binding|protein domain specific binding|protein heterodimerization activity|receptor binding|retinoic acid binding|retinoic acid receptor activity|retinoic acid-responsive element binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00143)		Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Isotretinoin(DB00982)|Tamibarotene(DB04942)|Tazarotene(DB00799)	CAGATGCACAACGCTGGCTTC	0.652		NaN	T	PML|ZNF145|TIF1|NUMA1|NPM1	APL								0	0	0	0.003163	0	15	71									
KRT33B	3884	broad.mit.edu	37	17	39521742	39521742	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:39521742C>T	uc002hwl.2	-	4	697	c.652G>A	c.(652-654)GCT>ACT	p.A218T		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	218	Linker 12.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				AGGTCCACAGCGGGAGCAGCG	0.562		NaN											0	0	0	0.00499	0	16	34									
MEOX1	4222	broad.mit.edu	37	17	41719371	41719371	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:41719371C>G	uc002idz.2	-	3	701	c.672G>C	c.(670-672)ATG>ATC	p.M224I	MEOX1_uc002iea.2_Missense_Mutation_p.E167Q|MEOX1_uc002ieb.2_Missense_Mutation_p.M109I	NM_004527	NP_004518	P50221	MEOX1_HUMAN	mesenchyme homeobox 1 isoform 1	224	Homeobox.					nucleus	sequence-specific DNA binding				0		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		GCTTCCACTTCATCCTTCGGT	0.582		NaN											0	0	0	0.012213	0	28	119									
GRN	2896	broad.mit.edu	37	17	42427117	42427117	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:42427117C>G	uc002igp.1	+	4	566	c.347C>G	c.(346-348)TCA>TGA	p.S116*	GRN_uc002igq.1_3'UTR|GRN_uc002igr.1_5'Flank	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	116					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TTCCAAAGATCAGGTGCAGCT	0.652		NaN											0	0	0	0.004672	0	3	20									
FMNL1	752	broad.mit.edu	37	17	43318986	43318986	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:43318986G>C	uc002iin.2	+	14	1770	c.1570G>C	c.(1570-1572)GGC>CGC	p.G524R	FMNL1_uc002iiq.2_Missense_Mutation_p.G102R|FMNL1_uc010dag.2_5'Flank	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	524	Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						GGTGCCGACCGGCTCCCCCAG	0.716		NaN											0	0	0	0.001168	0	4	5									
WNT9B	7484	broad.mit.edu	37	17	44954078	44954078	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:44954078G>A	uc002ikw.1	+	4	1105	c.1068G>A	c.(1066-1068)AAG>AAA	p.K356K	WNT9B_uc002ikx.1_Intron	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	356					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			ACACCTGCAAGCACTAGGCCT	0.627		NaN											0	0	0	0.010729	0	12	31									
NPEPPS	9520	broad.mit.edu	37	17	45689897	45689897	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:45689897G>A	uc002ilr.3	+	18	2390	c.2167G>A	c.(2167-2169)GAA>AAA	p.E723K	NPEPPS_uc010wkt.1_Missense_Mutation_p.E719K|NPEPPS_uc010wku.1_Missense_Mutation_p.E687K|NPEPPS_uc010wkv.1_Missense_Mutation_p.E277K|NPEPPS_uc002ils.1_Missense_Mutation_p.E156K	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	723					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						GGCAACGTTAGAAGAAGCCCG	0.458		NaN											0	0	0	0.00499	0	16	55									
SNX11	29916	broad.mit.edu	37	17	46189426	46189426	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:46189426G>A	uc002inf.1	+	3	375	c.21G>A	c.(19-21)ATG>ATA	p.M7I	SNX11_uc010wlg.1_5'UTR|SNX11_uc010wlh.1_5'UTR|SNX11_uc010wli.1_5'UTR|SNX11_uc010wlj.1_Intron|SNX11_uc002ing.1_Missense_Mutation_p.M7I|SNX11_uc002inh.1_Missense_Mutation_p.M7I	NM_152244	NP_689450	Q9Y5W9	SNX11_HUMAN	sorting nexin 11	7					cell communication|protein transport	membrane	phosphatidylinositol binding				0						GGTGTAGGATGTCGGAGAACC	0.458		NaN											0	0	0	0.013537	0	12	51									
HOXB8	3218	broad.mit.edu	37	17	46690570	46690570	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:46690570C>T	uc002inw.2	-	2	961	c.726G>A	c.(724-726)AAG>AAA	p.K242K	HOXB7_uc002inv.2_5'Flank	NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	242						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AAGCCTACTTCTTGTCGCCCT	0.468		NaN											0	0	0	0.007413	0	16	83									
SNF8	11267	broad.mit.edu	37	17	47013602	47013602	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:47013602G>A	uc002ioj.2	-	5	410	c.352C>T	c.(352-354)CTG>TTG	p.L118L	SNF8_uc002iok.2_Silent_p.L118L	NM_007241	NP_009172	Q96H20	SNF8_HUMAN	EAP30 subunit of ELL complex	118					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding				0						AAAGTTATCAGACCTGTTTGG	0.428		NaN											0	0	0	0.009096	0	3	24									
PHB	5245	broad.mit.edu	37	17	47486813	47486813	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:47486813T>C	uc002iox.1	-	4	346	c.273A>G	c.(271-273)ACA>ACG	p.T91T		NM_002634	NP_002625	P35232	PHB_HUMAN	prohibitin	91					cellular response to interleukin-6|DNA replication|glucocorticoid receptor signaling pathway|histone deacetylation|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|progesterone receptor signaling pathway|regulation of apoptosis	integral to plasma membrane|mitochondrial inner membrane|nucleoplasm	histone deacetylase binding|transcription regulatory region DNA binding				0	all_cancers(4;2.62e-14)|Breast(4;4.21e-29)|all_epithelial(4;6.9e-18)		Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)			GGATGCGCAGTGTGATGTTGA	0.448		NaN											0	0	0	0.00632	0	26	55									
EME1	146956	broad.mit.edu	37	17	48450605	48450605	+	Translation_Start_Site	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:48450605G>A	uc002iqs.1	+	1	16	c.-57G>A	c.(-59--55)GCGTG>GCATG		MRPL27_uc002iqq.2_5'Flank|MRPL27_uc002iqr.2_5'Flank|EME1_uc010dbp.1_5'Flank	NM_152463	NP_689676	Q96AY2	EME1_HUMAN	essential meiotic endonuclease 1 homolog 1						DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding				0	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			CGGGCCCTGCGTGGCAGTTGA	0.597		NaN						Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.009096	0	4	4									
CUEDC1	404093	broad.mit.edu	37	17	55950043	55950043	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:55950043G>A	uc002ivd.1	-	5	1484	c.765C>T	c.(763-765)TTC>TTT	p.F255F	CUEDC1_uc002ive.1_Silent_p.F255F	NM_017949	NP_060419	Q9NWM3	CUED1_HUMAN	CUE domain-containing 1	255										skin(2)	2						GAGCGAGGAGGAAGTCGCGGT	0.597		NaN											0	0	0	0.001168	0	5	37									
RAD51C	5889	broad.mit.edu	37	17	56774148	56774148	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:56774148G>A	uc002iwu.2	+	3	541	c.499G>A	c.(499-501)GAT>AAT	p.D167N	RAD51C_uc010woa.1_Missense_Mutation_p.D167N|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_Intron|RAD51C_uc002iww.2_Intron|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	167					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTTTATGGTTGATAGAGTGGT	0.413		NaN						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	0.008361	0	29	42									
RAD51C	5889	broad.mit.edu	37	17	56780655	56780655	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:56780655T>C	uc002iwu.2	+	4	712	c.670T>C	c.(670-672)TAT>CAT	p.Y224H	RAD51C_uc010woa.1_Missense_Mutation_p.Y224H|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	224					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCACAAGTTTATCTTCTTCC	0.348		NaN						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	0.003954	0	24	42									
TRIM37	4591	broad.mit.edu	37	17	57181659	57181659	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:57181659T>C	uc002iwy.3	-	2	562	c.118A>G	c.(118-120)ATT>GTT	p.I40V	TRIM37_uc002iwz.3_Missense_Mutation_p.I40V|TRIM37_uc002ixa.3_5'UTR|TRIM37_uc010woc.1_Intron|uc002ixb.2_5'Flank	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	40	RING-type; degenerate.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CTTACCCTAATACAGCTGAAA	0.353		NaN							Mulibrey_Nanism				0	0	0	0.004482	0	8	26									
KCNH6	81033	broad.mit.edu	37	17	61615788	61615788	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:61615788C>T	uc002jay.2	+	8	1799	c.1719C>T	c.(1717-1719)CCC>CCT	p.P573P	KCNH6_uc010wpl.1_Silent_p.P450P|KCNH6_uc010wpm.1_Silent_p.P573P|KCNH6_uc002jaz.1_Silent_p.P520P	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	573	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	AGGGCTTCCCCGAGTGCCTGC	0.731		NaN											0	0	0	0.008291	0	8	13									
POLG2	11232	broad.mit.edu	37	17	62493064	62493064	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:62493064C>T	uc002jei.2	-	1	106	c.23G>A	c.(22-24)AGG>AAG	p.R8K	POLG2_uc010deg.1_Missense_Mutation_p.R8K	NM_007215	NP_009146	Q9UHN1	DPOG2_HUMAN	DNA polymerase subunit gamma-2, mitochondrial	8					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)	1	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			ATGGCAGGCCCTGACGGCTAC	0.567		NaN											0	0	0	0.006122	0	16	53									
BTBD17	388419	broad.mit.edu	37	17	72352856	72352856	+	Silent	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:72352856G>T	uc002jkn.2	-	3	1377	c.1377C>A	c.(1375-1377)GCC>GCA	p.A459A		NM_001080466	NP_001073935	A6NE02	BTBDH_HUMAN	BTB (POZ) domain containing 17 precursor	459						extracellular region					0						GCAGGTGCAGGGCGTTCTCAA	0.647		NaN											1	0	2.98393e-07	0.00278	3.13295e-07	20	72									
GRIN2C	2905	broad.mit.edu	37	17	72848655	72848655	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:72848655G>A	uc002jlt.1	-	3	651	c.495C>T	c.(493-495)TTC>TTT	p.F165F	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_Silent_p.F165F|GRIN2C_uc002jlv.1_3'UTR	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	165	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	TGATGACGGCGAAGGCGCTCC	0.701		NaN											0	0	0	0.004482	0	6	17									
CASKIN2	57513	broad.mit.edu	37	17	73498946	73498946	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:73498946C>G	uc002joc.2	-	18	2759	c.2209G>C	c.(2209-2211)GAG>CAG	p.E737Q	CASKIN2_uc010wsc.1_Missense_Mutation_p.E655Q	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	737	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGGGGCCGCTCTGTGCCCTCT	0.657		NaN											0	0	0	0.000602	0	4	27									
TSEN54	283989	broad.mit.edu	37	17	73515107	73515107	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:73515107T>C	uc002jof.1	+	6	533	c.500T>C	c.(499-501)GTG>GCG	p.V167A	TSEN54_uc002joe.1_Silent_p.C164C	NM_207346	NP_997229	Q7Z6J9	SEN54_HUMAN	tRNA splicing endonuclease 54 homolog	167					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	nucleolus				ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTGGGTTATGTGGTTCGACGA	0.453		NaN											0	0	0	0.01441	0	43	72									
UNK	85451	broad.mit.edu	37	17	73813469	73813469	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:73813469C>T	uc002jpm.2	+	10	1395	c.1395C>T	c.(1393-1395)TCC>TCT	p.S465S		NM_001080419	NP_001073888	Q9C0B0	UNK_HUMAN	zinc finger CCCH-type domain containing 5	389							nucleic acid binding|zinc ion binding				0			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CACCGGGCTCCATCAGGAAGC	0.657		NaN											0	0	0	0.00278	0	20	83									
QRICH2	84074	broad.mit.edu	37	17	74288992	74288992	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:74288992C>A	uc002jrd.1	-	4	1498	c.1318G>T	c.(1318-1320)GAT>TAT	p.D440Y	QRICH2_uc010wsz.1_Missense_Mutation_p.D366Y|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	440	Gln-rich.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						ccagactgatccattccaggc	0.119		NaN											1	0	0.000442599	0.006214	0.000456911	9	20									
TMC8	147138	broad.mit.edu	37	17	76134245	76134245	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:76134245C>T	uc002jup.2	+	12	1891	c.1509C>T	c.(1507-1509)CTC>CTT	p.L503L	TMC8_uc002juq.2_Silent_p.L280L|TMC8_uc010wtr.1_3'UTR|TMC8_uc002jur.1_5'UTR	NM_152468	NP_689681	Q8IU68	TMC8_HUMAN	transmembrane channel-like 8	503	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.192)			GCGTCTTCCTCTTCCTCACCT	0.617		NaN							Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.00245	0	13	66									
DNAH17	8632	broad.mit.edu	37	17	76430168	76430168	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:76430168T>C	uc010dhp.1	-	20	3389	c.3167A>G	c.(3166-3168)AAC>AGC	p.N1056S	DNAH17_uc002jvq.2_Missense_Mutation_p.N341S|DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GAGGTCCCCGTTGTTGAAGGG	0.567		NaN											0	0	0	0.013726	0	30	126									
SLC38A10	124565	broad.mit.edu	37	17	79220205	79220205	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:79220205C>T	uc002jzz.1	-	16	2886	c.2511G>A	c.(2509-2511)CAG>CAA	p.Q837Q	SLC38A10_uc002jzy.1_Silent_p.Q755Q	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	837					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGGCATCCTTCTGGCCATCTC	0.716		NaN											0	0	0	0.00308	0	7	25									
SLC38A10	124565	broad.mit.edu	37	17	79257211	79257211	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:79257211G>A	uc002jzz.1	-	4	730	c.355C>T	c.(355-357)CAG>TAG	p.Q119*	SLC38A10_uc002jzy.1_Nonsense_Mutation_p.Q37*|SLC38A10_uc002kab.2_Nonsense_Mutation_p.Q119*	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	119					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ATCCTTACCTGAAACCCGAAC	0.602		NaN											0	0	0	0.008291	0	9	12									
ASPSCR1	79058	broad.mit.edu	37	17	79954451	79954451	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:79954451C>T	uc002kcx.2	+	7	759	c.662C>T	c.(661-663)TCA>TTA	p.S221L	ASPSCR1_uc002kcw.1_Missense_Mutation_p.S221L|ASPSCR1_uc002kcy.2_Missense_Mutation_p.S221L|ASPSCR1_uc002kcz.2_Intron|ASPSCR1_uc002kda.2_Missense_Mutation_p.S144L|ASPSCR1_uc002kdb.1_Missense_Mutation_p.S144L	NM_024083	NP_076988	Q9BZE9	ASPC1_HUMAN	alveolar soft part sarcoma chromosome region,	221							protein binding		ASPSCR1/TFE3(161)	soft_tissue(118)|kidney(43)|breast(1)	162	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			GCGGACACCTCAGGGCCCTGC	0.682		NaN	T	TFE3	alveolar soft part sarcoma								0	0	0	0.001168	0	6	23									
TBCD	6904	broad.mit.edu	37	17	80899327	80899327	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:80899327C>T	uc002kfz.2	+	38	3662	c.3532C>T	c.(3532-3534)CTG>TTG	p.L1178L	TBCD_uc002kfy.1_Silent_p.L1216L|TBCD_uc002kgc.2_Silent_p.L297L|TBCD_uc002kgd.2_Silent_p.L170L	NM_005993	NP_005984	Q9BTW9	TBCD_HUMAN	beta-tubulin cofactor D	1178					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity				0	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			GTGTGACCTTCTGGGCGTACC	0.627		NaN											0	0	0	0.004672	0	3	8									
YES1	7525	broad.mit.edu	37	18	724590	724590	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:724590T>C	uc002kky.2	-	12	1687	c.1466A>G	c.(1465-1467)TAC>TGC	p.Y489C	YES1_uc002kkz.2_Missense_Mutation_p.Y489C	NM_005433	NP_005424	P07947	YES_HUMAN	viral oncogene yes-1 homolog 1	489	Protein kinase.				blood coagulation|leukocyte migration|regulation of vascular permeability|T cell costimulation	cytosol|plasma membrane	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|ovary(1)	3					Dasatinib(DB01254)	CGGCATCCTGTATCCTCGCTC	0.413		NaN											0	0	0	0.00278	0	23	58									
SMCHD1	23347	broad.mit.edu	37	18	2750410	2750410	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:2750410T>C	uc002klm.3	+	32	4259	c.4070T>C	c.(4069-4071)ATT>ACT	p.I1357T	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1357					chromosome organization		ATP binding				0						GGACCTATAATTAAGTTAATG	0.383		NaN											0	0	0	0.010729	0	11	29									
AFG3L2	10939	broad.mit.edu	37	18	12337383	12337383	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:12337383C>G	uc002kqz.1	-	16	2245	c.2132G>C	c.(2131-2133)AGA>ACA	p.R711T		NM_006796	NP_006787	Q9Y4W6	AFG32_HUMAN	AFG3 ATPase family gene 3-like 2	711					cell death|protein catabolic process|proteolysis	integral to membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding				0					Adenosine triphosphate(DB00171)	AGCTACTGTTCTTTTATAAGC	0.393		NaN											0	0	0	0.00333	0	22	38									
POTEC	388468	broad.mit.edu	37	18	14534973	14534973	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:14534973C>T	uc010dln.2	-	4	1298	c.844G>A	c.(844-846)GAA>AAA	p.E282K	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	282	ANK 5.									skin(3)	3						TGTTTTTGTTCATGTACGCCA	0.303		NaN											0	0	0	0.006214	0	5	56									
C18orf8	29919	broad.mit.edu	37	18	21084405	21084405	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:21084405C>G	uc010xax.1	+	2	294	c.173C>G	c.(172-174)TCA>TGA	p.S58*	C18orf8_uc010xau.1_5'UTR|C18orf8_uc010xav.1_Nonsense_Mutation_p.S58*|C18orf8_uc010xaw.1_5'UTR|C18orf8_uc002kul.2_RNA	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	58										ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AATCCCATCTCATTTAGGTAA	0.378		NaN											0	0	0	0.013726	0	29	83									
NPC1	4864	broad.mit.edu	37	18	21148963	21148963	+	Splice_Site	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:21148963C>T	uc002kum.3	-	4	562	c.288_splice	c.e4-1	p.R96_splice	NPC1_uc010xba.1_Splice_Site	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor						autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GGATGGACATCTAAAGGAAAA	0.338		NaN											0	0	0	0.00308	0	6	16									
ZNF521	25925	broad.mit.edu	37	18	22805190	22805190	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:22805190C>A	uc002kvk.2	-	4	2939	c.2692G>T	c.(2692-2694)GAA>TAA	p.E898*	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Nonsense_Mutation_p.E898*|ZNF521_uc002kvl.2_Nonsense_Mutation_p.E678*	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	898	C2H2-type 21; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGCAAAGTTTCCATAGTGTAG	0.502		NaN	T	PAX5	ALL								1	0	1.75199e-13	0.007291	1.88071e-13	29	35									
KIAA1012	22878	broad.mit.edu	37	18	29419397	29419397	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:29419397C>G	uc002kxc.3	-	27	4225	c.3861G>C	c.(3859-3861)TTG>TTC	p.L1287F	KIAA1012_uc002kxb.3_Missense_Mutation_p.L1233F|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1287					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TGAAAAATTTCAATAGTTCCA	0.328		NaN											0	0	0	0.001855	0	13	44									
KATNAL2	83473	broad.mit.edu	37	18	44595908	44595908	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr18:44595908C>T	uc002lco.2	+	10	923	c.729C>T	c.(727-729)TTC>TTT	p.F243F	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lcp.3_Silent_p.F170F	NM_031303	NP_112593	Q8IYT4	KATL2_HUMAN	katanin p60 subunit A-like 2	315						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						AAACAACCTTCTTTAACATTT	0.378		NaN											0	0	0	0.004007	0	16	49									
C19orf35	374872	broad.mit.edu	37	19	2276228	2276228	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:2276228G>A	uc002lvn.2	-	4	973	c.873C>T	c.(871-873)GCC>GCT	p.A291A	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	291										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAACTTCAGGGCCGCGCTCA	0.726		NaN											0	0	0	0.001168	0	6	3									
GTF2F1	2962	broad.mit.edu	37	19	6381161	6381161	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:6381161C>T	uc002meq.2	-	10	1349	c.1064G>A	c.(1063-1065)AGC>AAC	p.S355N	GTF2F1_uc010xjb.1_Missense_Mutation_p.S176N|GTF2F1_uc010xjc.1_Missense_Mutation_p.S270N	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	355					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						GGAGGCCTCGCTGTCAATGTC	0.677		NaN											0	0	0	0.00308	0	7	7									
TIMM44	10469	broad.mit.edu	37	19	7992108	7992108	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:7992108C>T	uc002miz.2	-	13	1325	c.1323G>A	c.(1321-1323)CTG>CTA	p.L441L	TIMM44_uc002mja.2_Silent_p.L181L|CTXN1_uc002miy.3_5'Flank	NM_006351	NP_006342	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44	441					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						CCGAGATGTCCAGGAGCCGCC	0.672		NaN											0	0	0	0.007413	0	19	21									
MUC16	94025	broad.mit.edu	37	19	9057298	9057298	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:9057298C>T	uc002mkp.2	-	3	30352	c.30148G>A	c.(30148-30150)GTG>ATG	p.V10050M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10052	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGTGAAGTCACAGAAAAAGAG	0.463		NaN											0	0	0	0.004007	0	16	24									
MAN2B1	4125	broad.mit.edu	37	19	12758381	12758381	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:12758381G>A	uc002mub.2	-	22	2772	c.2696C>T	c.(2695-2697)TCG>TTG	p.S899L	MAN2B1_uc010dyv.1_Missense_Mutation_p.S898L	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	899					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						CAGGTGCACCGAGGGCGGCAG	0.692		NaN											0	0	0	0.007291	0	27	23									
TNPO2	30000	broad.mit.edu	37	19	12825962	12825962	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:12825962C>T	uc002muo.2	-	8	855	c.670G>A	c.(670-672)GAT>AAT	p.D224N	TNPO2_uc002mup.2_Missense_Mutation_p.D316N|TNPO2_uc002muq.2_Missense_Mutation_p.D224N|TNPO2_uc002mur.2_Missense_Mutation_p.D224N	NM_001136196	NP_001129668	O14787	TNPO2_HUMAN	transportin 2 (importin 3, karyopherin beta 2b)	224	HEAT 3.				intracellular protein transport	cytoplasm|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			ovary(1)	1						GGGTCATCATCCACAGCCAGG	0.622		NaN											0	0	0	0.00278	0	18	27									
RASAL3	64926	broad.mit.edu	37	19	15562677	15562677	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:15562677G>A	uc002nbe.2	-	18	3051	c.2965C>T	c.(2965-2967)CCA>TCA	p.P989S	WIZ_uc002nbb.3_5'Flank|RASAL3_uc002nbd.2_3'UTR|RASAL3_uc010eaa.1_Missense_Mutation_p.P403S	NM_022904	NP_075055	Q86YV0	RASL3_HUMAN	RAS protein activator like 3	989					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity				0						CGCGTCCTTGGAGAAAGCTGC	0.602		NaN											0	0	0	0.007291	0	31	24									
NDUFA13	51079	broad.mit.edu	37	19	19626839	19626839	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:19626839G>C	uc010xqy.1	+	1	300	c.41G>C	c.(40-42)AGA>ACA	p.R14T	TSSK6_uc002nmq.2_5'Flank|TSSK6_uc002nmr.2_5'Flank|NDUFA13_uc002nms.2_Missense_Mutation_p.R14T|NDUFA13_uc010xqx.1_Missense_Mutation_p.R14T	NM_015965	NP_057049	Q9P0J0	NDUAD_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	Error:Variant_position_missing_in_Q9P0J0_after_alignment					apoptotic nuclear change|induction of apoptosis by extracellular signals|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|negative regulation of translation|protein import into nucleus|reactive oxygen species metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I|nucleoplasm	ATP binding|NADH dehydrogenase (ubiquinone) activity|protein binding				0					NADH(DB00157)	CTGGGCAAAAGAGGAGTAAAG	0.612		NaN											0	0	0	0.006122	0	18	20									
RYR1	6261	broad.mit.edu	37	19	39068655	39068655	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:39068655G>A	uc002oit.2	+	98	14400	c.14270G>A	c.(14269-14271)CGC>CAC	p.R4757H	RYR1_uc002oiu.2_Missense_Mutation_p.R4752H	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4757					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CACAATGAGCGCAAGCCCAAC	0.632		NaN											0	0	0	0.004007	0	14	27									
FCGBP	8857	broad.mit.edu	37	19	40366091	40366091	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:40366091A>G	uc002omp.3	-	30	14151	c.14143T>C	c.(14143-14145)TAC>CAC	p.Y4715H		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4715						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCTGCCACGTAGGTAGCCACT	0.662		NaN											0	0	0	0.010771	0	42	20									
SHKBP1	92799	broad.mit.edu	37	19	41096303	41096303	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:41096303C>T	uc002oob.2	+	16	1792	c.1743C>T	c.(1741-1743)GCC>GCT	p.A581A	SHKBP1_uc002ooc.2_Silent_p.A556A|SHKBP1_uc002ood.2_Intron|SHKBP1_uc010xvl.1_Silent_p.A504A|SHKBP1_uc002ooe.2_Silent_p.A418A|SHKBP1_uc002oof.2_Silent_p.A418A|SHKBP1_uc010xvm.1_Silent_p.A361A|SHKBP1_uc010xvn.1_Silent_p.A459A|LTBP4_uc002oog.1_5'Flank	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	581	WD 5.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TAACCACCGCCATGGACGGCC	0.697		NaN											0	0	0	0.003954	0	23	12									
CNFN	84518	broad.mit.edu	37	19	42891312	42891312	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:42891312C>T	uc002otp.3	-	4	387	c.332G>A	c.(331-333)CGA>CAA	p.R111Q	CNFN_uc002otq.3_Missense_Mutation_p.R124Q	NM_032488	NP_115877	Q9BYD5	CNFN_HUMAN	cornifelin	111					keratinization	cornified envelope|cytoplasm					0		Prostate(69;0.00899)				TCCTTACTCTCGGATCTTCAG	0.637		NaN											0	0	0	0.010504	0	18	16									
ZNF226	7769	broad.mit.edu	37	19	44680458	44680458	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:44680458C>T	uc002oyp.2	+	6	1187	c.1043C>T	c.(1042-1044)TCA>TTA	p.S348L	ZNF226_uc002oyq.2_Missense_Mutation_p.S231L|ZNF226_uc002oyr.2_Missense_Mutation_p.S231L|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.S348L|ZNF226_uc002oyt.2_Missense_Mutation_p.S348L	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	348	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				AGTCGTAGATCAGCACTTAAT	0.468		NaN											0	0	0	0.009718	0	43	28									
CLPTM1	1209	broad.mit.edu	37	19	45477814	45477814	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:45477814A>G	uc002pai.2	+	4	443	c.428A>G	c.(427-429)GAC>GGC	p.D143G	CLPTM1_uc010ejv.1_Missense_Mutation_p.D41G|CLPTM1_uc010xxf.1_Missense_Mutation_p.D41G|CLPTM1_uc010xxg.1_Missense_Mutation_p.D129G	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	143	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GAGAACTCAGACGGCTGCTAC	0.567		NaN											0	0	0	0.003271	0	33	27									
CLPTM1	1209	broad.mit.edu	37	19	45477816	45477816	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:45477816G>A	uc002pai.2	+	4	445	c.430G>A	c.(430-432)GGC>AGC	p.G144S	CLPTM1_uc010ejv.1_Missense_Mutation_p.G42S|CLPTM1_uc010xxf.1_Missense_Mutation_p.G42S|CLPTM1_uc010xxg.1_Missense_Mutation_p.G130S	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	144	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GAACTCAGACGGCTGCTACGA	0.572		NaN											0	0	0	0.013726	0	32	27									
NUCB1	4924	broad.mit.edu	37	19	49422510	49422510	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:49422510G>T	uc002plb.3	+	10	1041	c.969G>T	c.(967-969)AGG>AGT	p.R323S	NUCB1_uc002pla.2_Missense_Mutation_p.R323S|NUCB1_uc002plc.2_Missense_Mutation_p.R323S|NUCB1_uc002pld.2_5'UTR	NM_006184	NP_006175	Q02818	NUCB1_HUMAN	nucleobindin 1 precursor	323	EF-hand 2.					ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|membrane|microtubule cytoskeleton	calcium ion binding|DNA binding				0		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000171)|all cancers(93;0.000333)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0244)		CCACTCAGAGGAAGGAGTTTG	0.602		NaN											1	0	1.58986e-06	0.008291	1.66318e-06	7	65									
TSKS	60385	broad.mit.edu	37	19	50243365	50243365	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:50243365C>T	uc002ppm.2	-	10	1584	c.1573G>A	c.(1573-1575)GAG>AAG	p.E525K		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	525							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CGCAGGGCCTCGTCTTGGGCC	0.632		NaN											0	0	0	0.01441	0	68	35									
NLRP2	55655	broad.mit.edu	37	19	55493759	55493759	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:55493759A>G	uc002qij.2	+	6	779	c.693A>G	c.(691-693)GCA>GCG	p.A231A	NLRP2_uc010yfp.1_Silent_p.A208A|NLRP2_uc010esn.2_Silent_p.A207A|NLRP2_uc010eso.2_Silent_p.A228A|NLRP2_uc010esp.2_Silent_p.A209A	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	231	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TAGACTGGGCAGAGGACAACC	0.577		NaN											0	0	0	0.009535	0	29	17									
ZNF418	147686	broad.mit.edu	37	19	58441801	58441801	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:58441801G>A	uc002qqs.1	-	3	420	c.128C>T	c.(127-129)TCC>TTC	p.S43F	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Intron	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	43	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		CTTACCCAGGGAGGATATAAG	0.488		NaN											0	0	0	0.01441	0	70	47									
ZNF606	80095	broad.mit.edu	37	19	58489802	58489802	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:58489802G>A	uc002qqw.2	-	7	2864	c.2246C>T	c.(2245-2247)TCT>TTT	p.S749F	ZNF606_uc010yhp.1_Missense_Mutation_p.S659F	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	749	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		AATAAGGGAAGAATTCTTACA	0.373		NaN											0	0	0	0.01441	0	73	32									
SNTG2	54221	broad.mit.edu	37	2	1133464	1133464	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:1133464T>C	uc002qwq.2	+	6	508	c.380T>C	c.(379-381)ATA>ACA	p.I127T	SNTG2_uc002qwp.2_RNA|SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	127	PDZ.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GTTAATGGCATACATGTAGAA	0.269		NaN											0	0	0	0.00632	0	26	45									
ALLC	55821	broad.mit.edu	37	2	3730543	3730543	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:3730543C>T	uc010ewt.2	+	7	551	c.390C>T	c.(388-390)GAC>GAT	p.D130D		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	149							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		TAAAATCCGACGACTGGAGTT	0.428		NaN								HNSCC(21;0.051)			0	0	0	0.008361	0	30	96									
FAM84A	151354	broad.mit.edu	37	2	14774914	14774914	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:14774914C>T	uc002rbz.1	+	2	1053	c.811C>T	c.(811-813)CGT>TGT	p.R271C	FAM84A_uc002rca.1_5'Flank	NM_145175	NP_660158	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	271										pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			CGAGAAGCGCCGTATCGACGC	0.667		NaN											0	0	0	0.001168	0	5	30									
MYCN	4613	broad.mit.edu	37	2	16082291	16082291	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:16082291C>T	uc002rci.2	+	2	405	c.105C>T	c.(103-105)TTC>TTT	p.F35F	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.1_Silent_p.F27F	NM_005378	NP_005369	P04198	MYCN_HUMAN	v-myc myelocytomatosis viral related oncogene,	35					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			AAGATGACTTCTACTTCGGCG	0.647		NaN	A		neuroblastoma								0	0	0	0.006122	0	16	36									
RAD51AP2	729475	broad.mit.edu	37	2	17697834	17697834	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:17697834A>G	uc002rcl.1	-	1	1873	c.1849T>C	c.(1849-1851)TAT>CAT	p.Y617H	RAD51AP2_uc010exn.1_Missense_Mutation_p.Y608H	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	617										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTTTTTGGATACTTCAAATAA	0.269		NaN											0	0	0	0.00308	0	8	9									
PUM2	23369	broad.mit.edu	37	2	20455083	20455083	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:20455083T>G	uc002rds.1	-	17	2665	c.2642A>C	c.(2641-2643)CAT>CCT	p.H881P	PUM2_uc002rdq.1_Missense_Mutation_p.H260P|PUM2_uc002rdt.1_Missense_Mutation_p.H881P|PUM2_uc002rdr.2_Missense_Mutation_p.H741P|PUM2_uc010yjy.1_Missense_Mutation_p.H802P|PUM2_uc002rdu.1_Missense_Mutation_p.H881P|PUM2_uc010yjz.1_Missense_Mutation_p.H820P	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	883	Pumilio 5.|PUM-HD.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCATAAGGATGAGTTGAAAG	0.383		NaN											0	0	0	0.00245	0	14	26									
NCOA1	8648	broad.mit.edu	37	2	24905860	24905860	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:24905860G>A	uc002rfk.2	+	6	653	c.395G>A	c.(394-396)AGA>AAA	p.R132K	NCOA1_uc010eye.2_Missense_Mutation_p.R132K|NCOA1_uc002rfi.2_5'UTR|NCOA1_uc002rfj.2_Missense_Mutation_p.R132K|NCOA1_uc002rfl.2_Missense_Mutation_p.R132K	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	132	PAS.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGTGAAGGGAGAATTGTATTT	0.368		NaN	T	PAX3	alveolar rhadomyosarcoma								0	0	0	0.013726	0	32	50									
DTNB	1838	broad.mit.edu	37	2	25851188	25851188	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:25851188G>A	uc002rgh.2	-	4	464	c.214C>T	c.(214-216)CAT>TAT	p.H72Y	DTNB_uc010yko.1_Missense_Mutation_p.H15Y|DTNB_uc010ykp.1_5'UTR|DTNB_uc002rgo.2_Intron|DTNB_uc002rgi.2_Missense_Mutation_p.H72Y|DTNB_uc002rgj.2_Missense_Mutation_p.H72Y|DTNB_uc002rgk.2_Missense_Mutation_p.H72Y|DTNB_uc002rgl.2_Missense_Mutation_p.H72Y|DTNB_uc002rgq.2_Missense_Mutation_p.H72Y|DTNB_uc002rgm.2_Missense_Mutation_p.H72Y|DTNB_uc002rgn.2_5'UTR|DTNB_uc002rgr.1_Missense_Mutation_p.H61Y|DTNB_uc010ykq.1_5'UTR	NM_021907	NP_068707	O60941	DTNB_HUMAN	dystrobrevin, beta isoform 1	72						cytoplasm	calcium ion binding|zinc ion binding			large_intestine(2)|ovary(2)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCGGTGGTATGGTCCAGTGTA	0.418		NaN											0	0	0	0.010729	0	12	34									
OTOF	9381	broad.mit.edu	37	2	26703759	26703759	+	Silent	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:26703759C>G	uc002rhk.2	-	15	1825	c.1698G>C	c.(1696-1698)CGG>CGC	p.R566R	OTOF_uc002rhh.2_5'Flank|OTOF_uc002rhi.2_5'Flank|OTOF_uc002rhj.2_5'Flank	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	566	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGCCGGGCCCGGAAGGACA	0.642		NaN											0	0	0	0.003954	0	25	41									
OTOF	9381	broad.mit.edu	37	2	26739468	26739468	+	Splice_Site	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:26739468C>G	uc002rhk.2	-	5	455	c.328_splice	c.e5-1	p.T110_splice	OTOF_uc010ylb.1_Splice_Site	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a						cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAGGCTGGTCTGAAGGGAGG	0.537		NaN											0	0	0	0.006214	0	10	82									
PREB	10113	broad.mit.edu	37	2	27355129	27355129	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:27355129C>T	uc002rix.1	-	6	1148	c.895G>A	c.(895-897)GGC>AGC	p.G299S	PREB_uc002riy.1_Missense_Mutation_p.G227S|PREB_uc002riz.1_RNA|PREB_uc002rja.1_Intron	NM_013388	NP_037520	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding protein	299	Cytoplasmic (Potential).|WD 3.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACTTCATGGCCACAGGACTTG	0.612		NaN											0	0	0	0.003163	0	15	136									
CAD	790	broad.mit.edu	37	2	27440858	27440858	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:27440858G>A	uc002rji.2	+	2	358	c.196G>A	c.(196-198)GAA>AAA	p.E66K	CAD_uc010eyw.2_Missense_Mutation_p.E66K	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	66	GATase (Glutamine amidotransferase).				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CCCCCCAGATGAAATGGATGA	0.502		NaN											0	0	0	0.00499	0	17	59									
CAD	790	broad.mit.edu	37	2	27449800	27449800	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:27449800A>G	uc002rji.2	+	15	2419	c.2257A>G	c.(2257-2259)ACA>GCA	p.T753A	CAD_uc010eyw.2_Missense_Mutation_p.T690A	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	753	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GCGAGTCAGCACAAAGATTGG	0.532		NaN											0	0	0	0.01441	0	44	97									
LCLAT1	253558	broad.mit.edu	37	2	30790955	30790955	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:30790955G>C	uc002rnj.2	+	6	864	c.655G>C	c.(655-657)GCT>CCT	p.A219P	LCLAT1_uc010ymp.1_Missense_Mutation_p.A57P|LCLAT1_uc002rnk.1_Missense_Mutation_p.A219P|LCLAT1_uc002rnl.2_Missense_Mutation_p.A181P|LCLAT1_uc010ymq.1_Missense_Mutation_p.A181P	NM_182551	NP_872357	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1 isoform 1	219					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			ovary(2)	2						TAATGCATTTGCTGAAAAAAA	0.343		NaN											0	0	0	0.005443	0	25	46									
GALM	130589	broad.mit.edu	37	2	38956810	38956810	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:38956810G>A	uc002rqy.2	+	5	999	c.747G>A	c.(745-747)AAG>AAA	p.K249K		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	249					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				TCTGTCTGAAGGGATCTAAAG	0.438		NaN											0	0	0	0.008361	0	29	74									
GALM	130589	broad.mit.edu	37	2	38958959	38958959	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:38958959G>A	uc002rqy.2	+	6	1111	c.859G>A	c.(859-861)GAT>AAT	p.D287N		NM_138801	NP_620156	Q96C23	GALM_HUMAN	galactose mutarotase	287					hexose metabolic process	cytoplasm	aldose 1-epimerase activity|carbohydrate binding				0		all_hematologic(82;0.248)				CAACTTCCTGGATGGCACATT	0.527		NaN											0	0	0	0.010818	0	31	66									
MAP4K3	8491	broad.mit.edu	37	2	39664039	39664039	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:39664039G>A	uc002rro.2	-	1	181	c.90C>T	c.(88-90)GTC>GTT	p.V30V	MAP4K3_uc002rrp.2_Silent_p.V30V|uc002rrq.2_Intron|uc002rrr.1_5'Flank	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	30	Protein kinase.|ATP (By similarity).				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TTACCTTGTAGACGTCGCCGT	0.701		NaN											0	0	0	0.004482	0	8	14									
C2orf61	285051	broad.mit.edu	37	2	47378469	47378469	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:47378469C>T	uc002rvs.2	-	3	454	c.327G>A	c.(325-327)AAG>AAA	p.K109K	C2orf61_uc010fbd.2_RNA|C2orf61_uc010yog.1_Silent_p.K109K	NM_173649	NP_775920	Q8N801	CB061_HUMAN	hypothetical protein LOC285051 isoform 2	109								p.0?(2)			0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CCACTTGCTTCTTTAACAGGT	0.453		NaN											0	0	0	0.012213	0	32	72									
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48848387	48848387	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:48848387C>T	uc010yol.1	+	4	2364	c.2317C>T	c.(2317-2319)CAG>TAG	p.Q773*	STON1-GTF2A1L_uc002rwp.1_Nonsense_Mutation_p.Q773*|GTF2A1L_uc002rws.1_Nonsense_Mutation_p.Q69*|GTF2A1L_uc010yom.1_Nonsense_Mutation_p.Q35*|GTF2A1L_uc002rwt.2_Nonsense_Mutation_p.Q69*	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	773					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTTTACTCTTCAGTTGCCGCA	0.408		NaN											0	0	0	0.003163	0	15	27									
NRXN1	9378	broad.mit.edu	37	2	50850596	50850596	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:50850596A>G	uc010fbq.2	-	6	2566	c.1089T>C	c.(1087-1089)TAT>TAC	p.Y363Y	NRXN1_uc002rxb.3_Silent_p.Y10Y|NRXN1_uc002rxe.3_Silent_p.Y330Y|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	142	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAAGATTGACATAATCAGCCG	0.433		NaN											0	0	0	0.01441	0	59	100									
FAM161A	84140	broad.mit.edu	37	2	62067514	62067514	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:62067514C>T	uc010ypo.1	-	3	727	c.625G>A	c.(625-627)GAG>AAG	p.E209K	FAM161A_uc002sbm.3_Missense_Mutation_p.E209K|FAM161A_uc002sbn.3_Missense_Mutation_p.E19K|FAM161A_uc010fcm.1_RNA|FAM161A_uc010fcn.1_Missense_Mutation_p.E100K	NM_032180	NP_115556	Q3B820	F161A_HUMAN	hypothetical protein LOC84140	209					response to stimulus|visual perception	centrosome				large_intestine(2)|ovary(1)	3						ATATAATCCTCAACACAAAAG	0.408		NaN											0	0	0	0.007413	0	17	106									
OTX1	5013	broad.mit.edu	37	2	63283050	63283050	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:63283050C>A	uc002scd.2	+	5	912	c.664C>A	c.(664-666)CCC>ACC	p.P222T	OTX1_uc010ypt.1_Missense_Mutation_p.P156T	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	222						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					AGCCTCTTATCCCATGTCCTA	0.662		NaN											1	0	2.94398e-08	0.007413	3.09477e-08	20	36									
MEIS1	4211	broad.mit.edu	37	2	66664922	66664922	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:66664922G>A	uc002sdu.2	+	2	523	c.66G>A	c.(64-66)ACG>ACA	p.T22T	MEIS1_uc002sdt.2_Silent_p.T22T|MEIS1_uc002sdv.2_Silent_p.T20T|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_5'Flank|MEIS1_uc002sdw.1_5'Flank	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	22							sequence-specific DNA binding transcription factor activity				0						TCCCCTCCACGATGTATGGGG	0.602		NaN											0	0	0	0.004007	0	14	37									
ETAA1	54465	broad.mit.edu	37	2	67630885	67630885	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:67630885G>A	uc002sdz.1	+	5	1210	c.1071G>A	c.(1069-1071)GTG>GTA	p.V357V		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	357						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						AATCATGTGTGACTTCCTGTA	0.353		NaN											0	0	0	0.00278	0	22	27									
ETAA1	54465	broad.mit.edu	37	2	67630955	67630955	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:67630955G>A	uc002sdz.1	+	5	1280	c.1141G>A	c.(1141-1143)GAT>AAT	p.D381N		NM_019002	NP_061875	Q9NY74	ETAA1_HUMAN	ETAA16 protein	381						cytoplasm|nucleus				ovary(3)|large_intestine(1)	4						TGATTTTGAGGATGATTGGGA	0.363		NaN											0	0	0	0.008361	0	28	46									
PCBP1	5093	broad.mit.edu	37	2	70315790	70315790	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:70315790C>T	uc002sgf.2	+	1	1206	c.915C>T	c.(913-915)ATC>ATT	p.I305I	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	305	KH 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						TTAATGAGATCCGCCAGATGT	0.502		NaN											0	0	0	0.00333	0	25	39									
HTRA2	27429	broad.mit.edu	37	2	74757805	74757805	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:74757805G>A	uc002smi.1	+	2	1170	c.568G>A	c.(568-570)GAT>AAT	p.D190N	AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_5'Flank|AUP1_uc002smg.2_5'Flank|AUP1_uc002smh.2_5'Flank|AUP1_uc010yrx.1_5'Flank|AUP1_uc010yry.1_5'Flank|HTRA2_uc002smj.1_Missense_Mutation_p.D190N|HTRA2_uc002smk.1_Missense_Mutation_p.D190N|HTRA2_uc002sml.1_Missense_Mutation_p.D190N|HTRA2_uc002smm.1_5'UTR|HTRA2_uc002smn.1_5'UTR|HTRA2_uc010ffl.2_5'UTR	NM_013247	NP_037379	O43464	HTRA2_HUMAN	HtrA serine peptidase 2 isoform 1 preproprotein	190	Serine protease.				apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			ovary(1)	1						GGTGGCTGCCGATGGGCTCAT	0.592		NaN											0	0	0	0.012319	0	22	50									
LRRTM4	80059	broad.mit.edu	37	2	77745831	77745831	+	Silent	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:77745831G>T	uc002snr.2	-	3	1579	c.1164C>A	c.(1162-1164)ACC>ACA	p.T388T	LRRTM4_uc002snq.2_Silent_p.T388T|LRRTM4_uc002sns.2_Silent_p.T388T|LRRTM4_uc002snt.2_Silent_p.T389T	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	388	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GTTTGAAGATGGTAGGTCTAG	0.473		NaN											1	0	6.72482e-11	0.003163	7.18314e-11	14	44									
CAPG	822	broad.mit.edu	37	2	85629268	85629268	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:85629268T>C	uc002spl.1	-	2	251	c.1A>G	c.(1-3)ATG>GTG	p.M1V	CAPG_uc002spm.1_Missense_Mutation_p.M1V|CAPG_uc010ysq.1_Missense_Mutation_p.M1V|CAPG_uc010fgi.1_Missense_Mutation_p.M1V|CAPG_uc010fgj.1_5'Flank	NM_001747	NP_001738	P40121	CAPG_HUMAN	gelsolin-like capping protein	1					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding				0						GCTGTGTACATGCTGTCTTCA	0.522		NaN											0	0	0	0.004482	0	6	6									
SMYD1	150572	broad.mit.edu	37	2	88402598	88402598	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:88402598G>A	uc002ssr.2	+	7	912	c.910G>A	c.(910-912)GAG>AAG	p.E304K	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_5'UTR	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						AGTGGTGAAGGAGATGATACA	0.443		NaN											0	0	0	0.005443	0	25	49									
TMEM182	130827	broad.mit.edu	37	2	103380863	103380863	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:103380863C>G	uc010fjb.2	+	3	495	c.308C>G	c.(307-309)TCG>TGG	p.S103W	TMEM182_uc002tcc.3_Missense_Mutation_p.S60W|TMEM182_uc002tcd.3_Missense_Mutation_p.S7W	NM_144632	NP_653233	Q6ZP80	TM182_HUMAN	transmembrane protein 182 precursor	103	Extracellular (Potential).					integral to membrane					0						GAGCACAACTCGACCTCCTAT	0.483		NaN											0	0	0	0.006999	0	38	63									
ANKRD57	65124	broad.mit.edu	37	2	110373335	110373335	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:110373335C>T	uc002tfb.2	+	1	1425	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L	SEPT10_uc010ywu.1_5'Flank|SEPT10_uc002tew.2_5'Flank|SEPT10_uc002tex.2_5'Flank|SEPT10_uc002tey.2_5'Flank|SEPT10_uc010ywv.1_5'Flank	NM_023016	NP_075392	Q53LP3	ANR57_HUMAN	ankyrin repeat domain 57	423											0						CCTCGCATCTCATCACCTACA	0.627		NaN											0	0	0	0.003954	0	23	38									
IL1A	3552	broad.mit.edu	37	2	113532667	113532667	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:113532667G>A	uc002tig.2	-	7	1753	c.793C>T	c.(793-795)CAG>TAG	p.Q265*		NM_000575	NP_000566	P01583	IL1A_HUMAN	interleukin 1, alpha proprotein	265					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			lung(1)	1						TCCAGTATCTGAAAGTCAGTG	0.458		NaN											0	0	0	0.007413	0	18	42									
BIN1	274	broad.mit.edu	37	2	127834283	127834283	+	Splice_Site	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:127834283C>T	uc002tns.1	-	2	430	c.85_splice	c.e2-1	p.V29_splice	BIN1_uc010yzf.1_Splice_Site_p.V5_splice|BIN1_uc010yzg.1_Splice_Site_p.V29_splice|BIN1_uc002tnu.1_Splice_Site_p.V29_splice|BIN1_uc002toa.1_Splice_Site_p.V29_splice|BIN1_uc002tnt.1_Splice_Site_p.V29_splice|BIN1_uc002tnv.1_Splice_Site_p.V29_splice|BIN1_uc002tnw.1_Splice_Site_p.V29_splice|BIN1_uc002tnx.1_Splice_Site_p.V29_splice|BIN1_uc002tny.1_Splice_Site_p.V29_splice|BIN1_uc002tnz.1_Splice_Site_p.V29_splice|BIN1_uc002tob.1_Splice_Site_p.V29_splice|BIN1_uc002toc.1_Splice_Site_p.V29_splice	NM_139343	NP_647593	O00499	BIN1_HUMAN	bridging integrator 1 isoform 1						cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				ovary(2)|central_nervous_system(2)|skin(2)|lung(1)	7	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TCTGGAGAACCTGCCGAAGCC	0.547		NaN											0	0	0	0.01441	0	51	79									
MAP3K2	10746	broad.mit.edu	37	2	128093472	128093472	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:128093472T>C	uc002toj.1	-	4	303	c.238A>G	c.(238-240)ATG>GTG	p.M80V	MAP3K2_uc010flz.1_Missense_Mutation_p.M80V	NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	80	OPR.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		TGTAGATCCATAGACTGTCCA	0.323		NaN											0	0	0	0.009096	0	3	4									
NCKAP5	344148	broad.mit.edu	37	2	133486457	133486457	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:133486457C>G	uc002ttp.2	-	18	5886	c.5512G>C	c.(5512-5514)GCT>CCT	p.A1838P	NCKAP5_uc002ttq.2_Missense_Mutation_p.A519P	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1838							protein binding				0						GGGTCTTCAGCATATCCGAAT	0.537		NaN											0	0	0	0.009718	0	43	205									
RAB3GAP1	22930	broad.mit.edu	37	2	135922246	135922246	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:135922246C>T	uc002tuj.2	+	23	2714	c.2689C>T	c.(2689-2691)CTG>TTG	p.L897L	RAB3GAP1_uc010fnf.2_Silent_p.L897L|RAB3GAP1_uc010fng.2_Silent_p.L722L|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	897						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		CATTCACAAGCTGTTTGTGAA	0.493		NaN											0	0	0	0.010729	0	11	27									
ZRANB3	84083	broad.mit.edu	37	2	135960517	135960517	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:135960517C>T	uc002tum.2	-	20	3143	c.3026G>A	c.(3025-3027)AGA>AAA	p.R1009K	ZRANB3_uc002tuk.2_Missense_Mutation_p.R552K|ZRANB3_uc002tul.2_Missense_Mutation_p.R1007K	NM_032143	NP_115519	Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	1009						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			lung(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.135)		CCCTGGGTTTCTTATCATTTC	0.433		NaN											0	0	0	0.00308	0	8	22									
SPOPL	339745	broad.mit.edu	37	2	139308578	139308578	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:139308578C>T	uc002tvh.2	+	4	706	c.306C>T	c.(304-306)TTC>TTT	p.F102F		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	102	MATH.					nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GAGCAAAATTCAAATTTTCCC	0.353		NaN											0	0	0	0.004656	0	24	56									
GALNT5	11227	broad.mit.edu	37	2	158165086	158165086	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:158165086A>C	uc002tzg.2	+	9	2783	c.2528A>C	c.(2527-2529)CAA>CCA	p.Q843P	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	843	Lumenal (Potential).|Ricin B-type lectin.				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						CAGCTTCAACAATTTAATTAC	0.388		NaN											0	0	0	0.01441	0	117	248									
BAZ2B	29994	broad.mit.edu	37	2	160257124	160257124	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:160257124G>A	uc002uao.2	-	17	3236	c.2884C>T	c.(2884-2886)CAG>TAG	p.Q962*	BAZ2B_uc002uap.2_Nonsense_Mutation_p.Q926*|BAZ2B_uc002uaq.1_Nonsense_Mutation_p.Q792*	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	962	Lys-rich.|Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						AGAATTTGCTGAGCTCGAAGT	0.259		NaN											0	0	0	0.001984	0	7	15									
COBLL1	22837	broad.mit.edu	37	2	165586561	165586561	+	Missense_Mutation	SNP	T	T	C	rs146685683		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:165586561T>C	uc010zcw.1	-	5	578	c.454A>G	c.(454-456)ACA>GCA	p.T152A	COBLL1_uc002ucp.2_Missense_Mutation_p.T99A|COBLL1_uc002ucq.2_Missense_Mutation_p.T99A|COBLL1_uc010zcx.1_Missense_Mutation_p.T145A|COBLL1_uc002ucs.1_RNA	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	137										ovary(2)|pancreas(1)	3						AGATCGATTGTGTAACTTGAT	0.343		NaN											0	0	0	0.010504	0	20	40									
CSRNP3	80034	broad.mit.edu	37	2	166535631	166535631	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:166535631G>C	uc002udf.2	+	7	1502	c.1126G>C	c.(1126-1128)GAA>CAA	p.E376Q	CSRNP3_uc002udg.2_Missense_Mutation_p.E376Q	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	376	Glu-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						ggaggaggaagaagaagagga	0.423		NaN											0	0	0	0.004007	0	17	38									
SCN1A	6323	broad.mit.edu	37	2	166900510	166900510	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:166900510C>T	uc010zcz.1	-	11	1730	c.1712G>A	c.(1711-1713)AGA>AAA	p.R571K	SCN1A_uc002udo.3_Missense_Mutation_p.R440K|SCN1A_uc010fpk.2_Missense_Mutation_p.R440K	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	571						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AAGGCTTGTTCTGCTATTTCG	0.438		NaN											0	0	0	0.004656	0	25	50									
B3GALT1	8708	broad.mit.edu	37	2	168725897	168725897	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:168725897C>T	uc002udz.1	+	2	699	c.348C>T	c.(346-348)TTC>TTT	p.F116F		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	116	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4						CCACCCTGTTCCTCCTGGGCA	0.488		NaN											0	0	0	0.008871	0	18	33									
LRP2	4036	broad.mit.edu	37	2	170175331	170175331	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:170175331G>C	uc002ues.2	-	3	464	c.251C>G	c.(250-252)TCC>TGC	p.S84C	LRP2_uc010zdf.1_Missense_Mutation_p.S84C	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	84	LDL-receptor class A 2.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACACACCCAGGAGTTGGGGAT	0.468		NaN											0	0	0	0.004482	0	7	71									
RBM45	129831	broad.mit.edu	37	2	178977522	178977522	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:178977522G>A	uc002ulv.2	+	1	341	c.249G>A	c.(247-249)ATG>ATA	p.M83I		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	83	RRM 1.				cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			GCAGGGCCATGGAGGAGATGC	0.647		NaN											0	0	0	0.00632	0	25	58									
TTN	7273	broad.mit.edu	37	2	179422796	179422796	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:179422796A>G	uc010zfg.1	-	277	79805	c.79581T>C	c.(79579-79581)ATT>ATC	p.I26527I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.I20222I|TTN_uc010zfi.1_Silent_p.I20155I|TTN_uc010zfj.1_Silent_p.I20030I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27454							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCAGCAGTAATTTCGGTAT	0.428		NaN											0	0	0	0.00623	0	37	80									
TTN	7273	broad.mit.edu	37	2	179439443	179439443	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:179439443T>C	uc010zfg.1	-	275	63936	c.63712A>G	c.(63712-63714)AGA>GGA	p.R21238G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R14933G|TTN_uc010zfi.1_Missense_Mutation_p.R14866G|TTN_uc010zfj.1_Missense_Mutation_p.R14741G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22165							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCATATCTATTCTGAGCT	0.463		NaN											0	0	0	0.003271	0	32	55									
TTN	7273	broad.mit.edu	37	2	179650673	179650673	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:179650673G>C	uc010zfg.1	-	14	2496	c.2272C>G	c.(2272-2274)CAC>GAC	p.H758D	TTN_uc010zfh.1_Missense_Mutation_p.H712D|TTN_uc010zfi.1_Missense_Mutation_p.H712D|TTN_uc010zfj.1_Missense_Mutation_p.H712D|TTN_uc002unb.2_Missense_Mutation_p.H758D|TTN_uc010frg.1_Missense_Mutation_p.H340D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	758							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGACAACGTGGGGTTCTGAG	0.488		NaN											0	0	0	0.00632	0	28	45									
BMPR2	659	broad.mit.edu	37	2	203420156	203420156	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:203420156G>A	uc002uzf.3	+	12	2916	c.1768G>A	c.(1768-1770)GAA>AAA	p.E590K	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	590	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						AATTAACTATGAACGACAGCA	0.463		NaN											0	0	0	0.014323	0	24	40									
INO80D	54891	broad.mit.edu	37	2	206921331	206921331	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:206921331C>T	uc002vaz.3	-	4	960	c.555G>A	c.(553-555)GAG>GAA	p.E185E		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	185					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTTTTAAAATCTCTGTCTCTC	0.498		NaN											0	0	0	0.000602	0	5	14									
TNS1	7145	broad.mit.edu	37	2	218762563	218762563	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:218762563C>G	uc002vgt.2	-	6	524	c.126G>C	c.(124-126)GAG>GAC	p.E42D	TNS1_uc002vgr.2_Missense_Mutation_p.E42D|TNS1_uc002vgs.2_Missense_Mutation_p.E42D|TNS1_uc010zjv.1_Missense_Mutation_p.E42D|TNS1_uc010fvj.1_Missense_Mutation_p.E110D|TNS1_uc010fvk.1_Missense_Mutation_p.E167D|TNS1_uc002vgu.3_Missense_Mutation_p.E73D|TNS1_uc002vgv.1_RNA	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	42	Phosphatase tensin-type.					cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TCTGCGCCACCTCACGGAGGT	0.572		NaN											0	0	0	0.008361	0	31	43									
C2orf62	375307	broad.mit.edu	37	2	219229358	219229358	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:219229358T>C	uc002vhr.2	+	7	667	c.638T>C	c.(637-639)CTG>CCG	p.L213P	C2orf62_uc002vhs.2_Intron	NM_198559	NP_940961	Q7Z7H3	CB062_HUMAN	hypothetical protein LOC375307	213											0		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGCAAAACCTGGGCTTCCAG	0.562		NaN											0	0	0	0.004878	0	38	51									
STK36	27148	broad.mit.edu	37	2	219537634	219537634	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:219537634C>G	uc002viu.2	+	2	348	c.82C>G	c.(82-84)CAG>GAG	p.Q28E	STK36_uc002viv.2_Missense_Mutation_p.Q28E|RNF25_uc002vit.2_5'Flank|RNF25_uc010fvw.2_5'Flank	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	28	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		ATACAGTGCTCAGGTGTTGCA	0.443		NaN											0	0	0	0.004289	0	37	54									
CHPF	79586	broad.mit.edu	37	2	220406655	220406655	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:220406655C>T	uc002vmc.3	-	2	798	c.571G>A	c.(571-573)GAC>AAC	p.D191N	CHPF_uc010zlh.1_Missense_Mutation_p.D29N|CHPF_uc002vmd.3_Missense_Mutation_p.D191N|TMEM198_uc002vme.2_5'Flank|TMEM198_uc002vmf.2_5'Flank	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	191	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CAGTCAAAGTCGTCGCCGTGC	0.687		NaN									OREG0015229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013537	0	12	18									
SCG2	7857	broad.mit.edu	37	2	224463114	224463114	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:224463114C>T	uc002vnm.2	-	2	1020	c.887G>A	c.(886-888)CGG>CAG	p.R296Q		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	296					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		ACTCTCTTTCCGAAGATCTTC	0.418		NaN											0	0	0	0.006122	0	18	136									
SERPINE2	5270	broad.mit.edu	37	2	224849561	224849561	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:224849561C>T	uc002vnu.2	-	5	1035	c.792G>A	c.(790-792)CCG>CCA	p.P264P	SERPINE2_uc002vnt.2_Silent_p.P264P|SERPINE2_uc010zlr.1_Silent_p.P276P|SERPINE2_uc002vnv.2_Silent_p.P264P	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	264					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TGGCAGACAGCGGAGTGGAGC	0.537		NaN											0	0	0	0.00499	0	18	37									
SERPINE2	5270	broad.mit.edu	37	2	224856541	224856541	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:224856541G>T	uc002vnu.2	-	4	907	c.664C>A	c.(664-666)CAG>AAG	p.Q222K	SERPINE2_uc002vnt.2_Missense_Mutation_p.Q222K|SERPINE2_uc010zlr.1_Missense_Mutation_p.Q234K|SERPINE2_uc002vnv.2_Missense_Mutation_p.Q222K	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	222					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		ACGGAGAGCTGGGCCAGCATT	0.527		NaN											1	0	1.5842e-08	0.001855	1.67351e-08	14	42									
COL4A3	1285	broad.mit.edu	37	2	228137702	228137702	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:228137702G>C	uc002vom.1	+	26	1958	c.1796G>C	c.(1795-1797)GGG>GCG	p.G599A	COL4A3_uc002von.1_Missense_Mutation_p.G599A|COL4A3_uc002voo.1_Missense_Mutation_p.G599A|COL4A3_uc002vop.1_Missense_Mutation_p.G599A|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	599	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGTCCTCCAGGGGATCCTGGC	0.557		NaN											0	0	0	0.005443	0	26	44									
FBXO36	130888	broad.mit.edu	37	2	230787323	230787323	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:230787323C>G	uc002vqa.2	+	1	117	c.94C>G	c.(94-96)CAG>GAG	p.Q32E	TRIP12_uc002vpw.1_5'Flank|TRIP12_uc002vpx.1_5'Flank|TRIP12_uc002vpy.1_5'Flank|TRIP12_uc010zlz.1_5'Flank|TRIP12_uc010fxh.1_5'Flank|FBXO36_uc002vpz.2_Missense_Mutation_p.Q32E|FBXO36_uc002vqb.2_5'UTR|FBXO36_uc010fxi.1_Missense_Mutation_p.Q32E|FBXO36_uc002vqc.2_RNA	NM_174899	NP_777559	Q8NEA4	FBX36_HUMAN	F-box protein 36	32										ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0179)|Lung NSC(271;0.0804)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;7.56e-14)|all cancers(144;7.74e-11)|Lung(119;0.00488)|LUSC - Lung squamous cell carcinoma(224;0.008)		CACCCGGTCTCAGGCAAGTGC	0.612		NaN											0	0	0	0.010729	0	12	34									
SP110	3431	broad.mit.edu	37	2	231035336	231035336	+	Splice_Site	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:231035336C>T	uc002vqh.3	-	17	2196	c.1956_splice	c.e17+1	p.K652_splice	SP110_uc002vqg.3_Splice_Site_p.K676_splice	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a						interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		ATGCTCTTTACCTTGTAAAAT	0.443		NaN											0	0	0	0.010729	0	10	25									
SP140L	93349	broad.mit.edu	37	2	231222548	231222548	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:231222548G>A	uc010fxm.1	+	3	227	c.136G>A	c.(136-138)GAG>AAG	p.E46K	SP140_uc010zma.1_RNA|SP140L_uc010fxn.1_5'UTR	NM_138402	NP_612411	Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	46	HSR.					nucleus	DNA binding|metal ion binding			central_nervous_system(1)	1						GGATGTAGATGAGGGACTTGT	0.398		NaN											0	0	0	0.009535	0	27	188									
PSMD1	5707	broad.mit.edu	37	2	231936987	231936987	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:231936987C>T	uc002vrn.1	+	7	870	c.739C>T	c.(739-741)CAG>TAG	p.Q247*	PSMD1_uc002vrm.1_Nonsense_Mutation_p.Q247*|PSMD1_uc010fxu.1_Nonsense_Mutation_p.Q111*	NM_002807	NP_002798	Q99460	PSMD1_HUMAN	proteasome 26S non-ATPase subunit 1	247					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			ovary(1)|skin(1)	2		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	GATGGCATATCAGATTTGTTT	0.403		NaN											0	0	0	0.01441	0	47	117									
GIGYF2	26058	broad.mit.edu	37	2	233626135	233626135	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:233626135G>A	uc002vti.3	+	10	858	c.521G>A	c.(520-522)CGA>CAA	p.R174Q	GIGYF2_uc010zmj.1_Missense_Mutation_p.R174Q|GIGYF2_uc002vtg.2_Missense_Mutation_p.R174Q|GIGYF2_uc002vtj.3_Missense_Mutation_p.R174Q|GIGYF2_uc002vtk.3_Missense_Mutation_p.R174Q|GIGYF2_uc002vth.3_Missense_Mutation_p.R174Q|GIGYF2_uc010zmk.1_RNA	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	174	Arg-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		AAACCAGGACGAAAAGATGTA	0.378		NaN											0	0	0	0.00499	0	14	28									
GIGYF2	26058	broad.mit.edu	37	2	233651882	233651882	+	Silent	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:233651882T>G	uc002vti.3	+	11	892	c.555T>G	c.(553-555)GGT>GGG	p.G185G	GIGYF2_uc010zmj.1_Silent_p.G185G|GIGYF2_uc002vtg.2_Silent_p.G185G|GIGYF2_uc002vtj.3_Silent_p.G207G|GIGYF2_uc002vtk.3_Silent_p.G185G|GIGYF2_uc002vth.3_Silent_p.G185G|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc010zml.1_Silent_p.G16G	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	185	Arg-rich.				cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		TTGAGGAAGGTGGACCAACAT	0.383		NaN											0	0	0	0.008291	0	9	41									
GIGYF2	26058	broad.mit.edu	37	2	233721509	233721509	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:233721509C>T	uc002vti.3	+	31	4176	c.3839C>T	c.(3838-3840)TCA>TTA	p.S1280L	GIGYF2_uc002vtj.3_Missense_Mutation_p.S1301L|GIGYF2_uc002vtk.3_Missense_Mutation_p.S1280L|GIGYF2_uc002vth.3_Missense_Mutation_p.S1274L|GIGYF2_uc010zmk.1_RNA|GIGYF2_uc002vtq.3_Missense_Mutation_p.S613L	NM_015575	NP_056390	Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2 isoform b	1280					cell death		protein binding			ovary(4)|central_nervous_system(3)	7		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		GCAGGATTTTCAGTCAATGCA	0.502		NaN											0	0	0	0.003271	0	32	66									
DEFB127	140850	broad.mit.edu	37	20	139536	139536	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:139536C>T	uc002wcy.1	+	2	171	c.171C>T	c.(169-171)ATC>ATT	p.I57I		NM_139074	NP_620713	Q9H1M4	DB127_HUMAN	defensin, beta 127 preproprotein	57					defense response to bacterium|innate immune response	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			GCCTCAATATCAAGGAACTGG	0.393		NaN											0	0	0	0.003163	0	12	14									
ANGPT4	51378	broad.mit.edu	37	20	896835	896835	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:896835A>G	uc002wei.2	-	1	126	c.23T>C	c.(22-24)CTG>CCG	p.L8P	ANGPT4_uc010zpn.1_Missense_Mutation_p.L2P	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	8					anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GCTGCCCTGCAGCATGGCTAG	0.602		NaN											0	0	0	0.010504	0	17	42									
SDCBP2	27111	broad.mit.edu	37	20	1291531	1291531	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:1291531T>C	uc002wev.3	-	8	866	c.737A>G	c.(736-738)AAA>AGA	p.K246R	SDCBP2_uc002weu.3_Missense_Mutation_p.K161R	NM_080489	NP_536737	Q9H190	SDCB2_HUMAN	syndecan binding protein 2 isoform a	246	PDZ 2.				intracellular signal transduction|intracellular transport|nervous system development	cytoplasm	protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity			large_intestine(1)|skin(1)	2						CATGATCTTTTTGTCCTAGGG	0.537		NaN											0	0	0	0.004482	0	9	20									
RASSF2	9770	broad.mit.edu	37	20	4778713	4778713	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:4778713A>T	uc002wld.2	-	3	132	c.78T>A	c.(76-78)CAT>CAA	p.H26Q	RASSF2_uc002wlc.2_5'Flank|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.H26Q	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	26					cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						AGGTCTTCAGATGCAAGAGAA	0.473		NaN											0	0	0	0.012319	0	17	40									
MCM8	84515	broad.mit.edu	37	20	5966679	5966679	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:5966679C>T	uc002wmi.2	+	16	2442	c.2065C>T	c.(2065-2067)CTT>TTT	p.L689F	MCM8_uc002wmj.2_Missense_Mutation_p.L673F|MCM8_uc002wmk.2_Missense_Mutation_p.L729F|MCM8_uc002wml.2_Missense_Mutation_p.L689F|MCM8_uc010gbp.2_Missense_Mutation_p.L642F|MCM8_uc002wmm.2_Missense_Mutation_p.L227F	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	689					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						TGCTCGAGTTCTTCAAGATTT	0.463		NaN											0	0	0	0.004656	0	25	39									
LRRN4	164312	broad.mit.edu	37	20	6025248	6025248	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:6025248G>C	uc002wmo.2	-	4	1163	c.939C>G	c.(937-939)CTC>CTG	p.L313L		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	313	Extracellular (Potential).					integral to membrane				skin(3)	3						AACTGCAAGTGAGGGGGTTGC	0.483		NaN											0	0	0	0.000602	0	5	14									
ESF1	51575	broad.mit.edu	37	20	13756530	13756530	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:13756530G>A	uc002woj.2	-	3	1132	c.1024C>T	c.(1024-1026)CGT>TGT	p.R342C	ESF1_uc002wok.1_Missense_Mutation_p.R342C	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						TCATCAGCACGAGGAGCATCT	0.368		NaN											0	0	0	0.009535	0	33	41									
CRNKL1	51340	broad.mit.edu	37	20	20020280	20020280	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:20020280G>A	uc002wrs.2	-	12	2033	c.2001C>T	c.(1999-2001)ATC>ATT	p.I667I		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	667	HAT 13.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						GTGGCTGACTGATGGCTAATT	0.378		NaN											0	0	0	0.00278	0	24	67									
RALGAPA2	57186	broad.mit.edu	37	20	20493296	20493296	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:20493296C>T	uc002wrz.2	-	32	4860	c.4717G>A	c.(4717-4719)GAG>AAG	p.E1573K	RALGAPA2_uc010gcx.2_Missense_Mutation_p.E1277K|RALGAPA2_uc010zsg.1_Missense_Mutation_p.E1021K|RALGAPA2_uc002wsa.1_Missense_Mutation_p.E345K	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1573					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TGGATATACTCATCCTCTTGA	0.468		NaN											0	0	0	0.001168	0	5	51									
NAPB	63908	broad.mit.edu	37	20	23375803	23375803	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:23375803A>G	uc002wta.2	-	4	432	c.315T>C	c.(313-315)AAT>AAC	p.N105N	NAPB_uc002wtc.2_Intron|NAPB_uc002wtb.2_Silent_p.N109N|NAPB_uc002wtd.3_Intron|NAPB_uc010zss.1_5'UTR|NAPB_uc010zst.1_Silent_p.N66N	NM_022080	NP_071363	Q9H115	SNAB_HUMAN	N-ethylmaleimide-sensitive factor attachment	105					intracellular protein transport|vesicle-mediated transport	membrane				ovary(1)	1	Lung NSC(19;0.0646)|Colorectal(13;0.0993)|all_lung(19;0.143)					CGATGGCTGCATTTAAGCAGT	0.428		NaN											0	0	0	0.001855	0	12	17									
CST4	1472	broad.mit.edu	37	20	23669392	23669392	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:23669392C>T	uc002wto.1	-	1	271	c.215G>A	c.(214-216)CGA>CAA	p.R72Q		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	72						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					CTCCCTGGCTCGCAGCACCTG	0.597		NaN											0	0	0	0.004482	0	9	43									
VSX1	30813	broad.mit.edu	37	20	25059543	25059543	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:25059543G>T	uc002wuf.2	-	3	584	c.549C>A	c.(547-549)TTC>TTA	p.F183L	VSX1_uc002wue.2_RNA|VSX1_uc010gdd.1_Missense_Mutation_p.F183L|VSX1_uc010gde.1_RNA|VSX1_uc010gdf.1_Missense_Mutation_p.F183L|VSX1_uc002wug.1_Missense_Mutation_p.F183L	NM_014588	NP_055403	Q9NZR4	VSX1_HUMAN	visual system homeobox 1 isoform a	183	Homeobox.				response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGGCCTCGCTGAATGCCTTCT	0.567		NaN											1	0	1.62565e-12	0.012213	1.74076e-12	33	50									
ZNF337	26152	broad.mit.edu	37	20	25657489	25657489	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:25657489C>T	uc002wva.2	-	4	957	c.435G>A	c.(433-435)AGG>AGA	p.R145R	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Silent_p.R113R|ZNF337_uc002wvb.2_Silent_p.R145R|ZNF337_uc002wvc.2_Silent_p.R145R	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACTGTTCCTCCTCCTTGAGC	0.443		NaN											0	0	0	0.004289	0	31	144									
ID1	3397	broad.mit.edu	37	20	30193214	30193214	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:30193214C>T	uc002wwg.1	+	1	123	c.24C>T	c.(22-24)ACC>ACT	p.T8T	ID1_uc002wwh.1_Silent_p.T8T|hsa-mir-3193|MI0014238_5'Flank	NM_002165	NP_002156	P41134	ID1_HUMAN	inhibitor of DNA binding 1 isoform a	8					angiogenesis|blood vessel endothelial cell migration|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by transcription factor localization|transforming growth factor beta receptor signaling pathway	cytoplasm	protein binding			ovary(1)	1	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.99e-05)|all cancers(5;0.000169)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			GTGGCAGCACCGCCACCGCCG	0.622		NaN											0	0	0	0.006122	0	14	29									
NFS1	9054	broad.mit.edu	37	20	34286483	34286483	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:34286483G>A	uc002xdw.1	-	2	191	c.127C>T	c.(127-129)CCC>TCC	p.P43S	NFS1_uc002xdt.1_5'UTR|NFS1_uc002xdu.1_5'UTR|NFS1_uc002xdv.1_RNA|NFS1_uc010zvk.1_5'UTR|NFS1_uc010zvl.1_Missense_Mutation_p.P43S|NFS1_uc002xdx.2_Missense_Mutation_p.P43S|ROMO1_uc002xdy.2_5'Flank|ROMO1_uc010gfm.2_5'Flank	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	43					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GTATCTGCGGGAACCGCAGAC	0.542		NaN											0	0	0	0.00499	0	15	54									
PHF20	51230	broad.mit.edu	37	20	34459579	34459579	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:34459579G>A	uc002xek.1	+	9	1221	c.1110G>A	c.(1108-1110)TTG>TTA	p.L370L	PHF20_uc002xei.1_Silent_p.L370L|PHF20_uc010gfo.1_Silent_p.L370L|PHF20_uc002xej.1_Silent_p.L254L	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	370					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					TAGGTCAGTTGAAGTCTGCTT	0.453		NaN											0	0	0	0.01441	0	57	72									
PPP1R16B	26051	broad.mit.edu	37	20	37547047	37547047	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:37547047T>C	uc002xje.2	+	11	1631	c.1442T>C	c.(1441-1443)CTG>CCG	p.L481P	PPP1R16B_uc010ggc.2_Missense_Mutation_p.L439P	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	481					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAGACGCTTCTGGAGCTGAAG	0.647		NaN											0	0	0	0.010818	0	31	50									
FAM83D	81610	broad.mit.edu	37	20	37570635	37570635	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:37570635A>G	uc002xjg.2	+	2	648	c.607A>G	c.(607-609)ATC>GTC	p.I203V	FAM83D_uc002xjf.2_Missense_Mutation_p.I203V	NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	173					cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				GTTCACAGACATCGACATCTT	0.478		NaN											0	0	0	0.004656	0	25	58									
SERINC3	10955	broad.mit.edu	37	20	43132519	43132519	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:43132519G>A	uc002xme.2	-	8	1126	c.992C>T	c.(991-993)TCT>TTT	p.S331F	SERINC3_uc002xmf.1_Missense_Mutation_p.S331F|SERINC3_uc010ggs.1_Missense_Mutation_p.S324F|SERINC3_uc010zwp.1_Missense_Mutation_p.S276F	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	331	Helical; (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			ATCCAGTAAAGACCCACTCTT	0.413		NaN											0	0	0	0.014323	0	23	40									
CDH22	64405	broad.mit.edu	37	20	44803691	44803691	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:44803691G>A	uc002xrm.2	-	11	2342	c.1941C>T	c.(1939-1941)CTC>CTT	p.L647L	CDH22_uc010ghk.1_Silent_p.L647L	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	647	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GGTGGCGCCTGAGGGTGAGGA	0.627		NaN											0	0	0	0.004656	0	23	25									
NCOA3	8202	broad.mit.edu	37	20	46279830	46279830	+	Silent	SNP	G	G	A	rs147918555		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:46279830G>A	uc002xtk.2	+	20	3961	c.3756G>A	c.(3754-3756)CAG>CAA	p.Q1252Q	NCOA3_uc010ght.1_Silent_p.Q1243Q|NCOA3_uc002xtl.2_Silent_p.Q1248Q|NCOA3_uc002xtm.2_Silent_p.Q1247Q|NCOA3_uc002xtn.2_Silent_p.Q1251Q|NCOA3_uc010zyc.1_Silent_p.Q1047Q	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1252	Poly-Gln.|Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						agcagcagcagcagcaacagc	0.289		NaN											0	0	0	0.009096	0	4	50									
SULF2	55959	broad.mit.edu	37	20	46292924	46292924	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:46292924G>C	uc002xto.2	-	15	2337	c.2007C>G	c.(2005-2007)ACC>ACG	p.T669T	SULF2_uc002xtr.2_Silent_p.T669T|SULF2_uc002xtq.2_Silent_p.T669T|SULF2_uc010zyd.1_5'UTR	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	669					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CTTTGTGCTGGGTGTGGTAGC	0.602		NaN									OREG0026005	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	8	25									
ATP9A	10079	broad.mit.edu	37	20	50255994	50255994	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:50255994C>T	uc002xwg.1	-	15	1556	c.1556G>A	c.(1555-1557)CGA>CAA	p.R519Q	ATP9A_uc010gih.1_Missense_Mutation_p.R383Q|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	519	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						AGACTGGTCTCGGCCCACCAG	0.547		NaN									OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.014323	0	23	40									
SALL4	57167	broad.mit.edu	37	20	50400861	50400861	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:50400861G>C	uc002xwh.3	-	4	3206	c.3105C>G	c.(3103-3105)GGC>GGG	p.G1035G	SALL4_uc010gii.2_Silent_p.G598G|SALL4_uc002xwi.3_Silent_p.G258G	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	1035					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GTTTGGGAACGCCGTCAGTAG	0.517		NaN											0	0	0	0.014323	0	21	80									
SLC17A9	63910	broad.mit.edu	37	20	61588228	61588228	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr20:61588228G>A	uc002yea.3	+	2	355	c.171G>A	c.(169-171)TGG>TGA	p.W57*	SLC17A9_uc002ydz.3_Nonsense_Mutation_p.W51*|SLC17A9_uc011aap.1_Nonsense_Mutation_p.W77*	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	57					exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						ACTTCGGCTGGAACAAGAAGG	0.632		NaN											0	0	0	0.006214	0	9	32									
TPTE	7179	broad.mit.edu	37	21	10934121	10934121	+	Splice_Site	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:10934121C>G	uc002yip.1	-	16	1225	c.857_splice	c.e16-1	p.S286_splice	TPTE_uc002yis.1_Splice_Site|TPTE_uc002yiq.1_Splice_Site_p.S268_splice|TPTE_uc002yir.1_Splice_Site_p.S248_splice|TPTE_uc010gkv.1_Splice_Site_p.S148_splice	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCTCTTTCACCTAAAATAAAT	0.299		NaN											0	0	0	0.00278	0	22	163									
MRPL39	54148	broad.mit.edu	37	21	26978900	26978900	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:26978900G>C	uc002ylo.2	-	2	155	c.141C>G	c.(139-141)CTC>CTG	p.L47L	MRPL39_uc002yln.2_Silent_p.L47L	NM_017446	NP_059142	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39 isoform a	47						mitochondrial ribosome	nucleotide binding				0						CTTTATTAAAGAGATCATTCC	0.413		NaN											0	0	0	0.00308	0	7	48									
GRIK1	2897	broad.mit.edu	37	21	30959910	30959910	+	Splice_Site	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:30959910C>G	uc002yno.1	-	12	2034	c.1570_splice	c.e12-1	p.R524_splice	GRIK1_uc002ynn.2_Splice_Site_p.R509_splice|GRIK1_uc011acs.1_Splice_Site_p.R524_splice|GRIK1_uc011act.1_Splice_Site_p.R385_splice|GRIK1_uc010glq.1_Splice_Site_p.R367_splice	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1						central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GGTCAGCCCTCTGCAAAAGCA	0.453		NaN											0	0	0	0.00308	0	8	15									
C21orf59	56683	broad.mit.edu	37	21	33979964	33979964	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:33979964A>G	uc002yqc.2	-	3	483	c.370T>C	c.(370-372)TCT>CCT	p.S124P	C21orf59_uc002ypx.1_Missense_Mutation_p.S17P|C21orf59_uc002ypy.1_Missense_Mutation_p.S124P|C21orf59_uc002ypz.1_Missense_Mutation_p.S124P|C21orf59_uc010glx.2_Intron|C21orf59_uc002yqd.2_Missense_Mutation_p.S124P|C21orf59_uc002yqb.3_Missense_Mutation_p.S124P|C21orf59_uc011adr.1_Missense_Mutation_p.S68P	NM_021254	NP_067077	P57076	CU059_HUMAN	hypothetical protein LOC56683	124						cytosol|nucleus					0						CCAACCTTAGATATTATTGCT	0.249		NaN											0	0	0	0.00245	0	15	40									
SYNJ1	8867	broad.mit.edu	37	21	34003938	34003938	+	Silent	SNP	T	T	C	rs61750219		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:34003938T>C	uc002yqh.2	-	32	4206	c.4206A>G	c.(4204-4206)CAA>CAG	p.Q1402Q	SYNJ1_uc011ads.1_3'UTR|SYNJ1_uc002yqf.2_3'UTR|SYNJ1_uc002yqg.2_Silent_p.Q1316Q|SYNJ1_uc002yqi.2_3'UTR|SYNJ1_uc002yqe.3_5'UTR	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1363	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						AAACATTACTTTGCGTTGCAG	0.448		NaN											0	0	0	0.013726	0	28	29									
DOPEY2	9980	broad.mit.edu	37	21	37571421	37571421	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:37571421C>T	uc002yvg.2	+	3	271	c.192C>T	c.(190-192)AGC>AGT	p.S64S	DOPEY2_uc011aeb.1_Silent_p.S64S	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	64					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TCCTCATCAGCAAAAGATTAG	0.458		NaN											0	0	0	0.007413	0	19	43									
ZNF295	49854	broad.mit.edu	37	21	43413477	43413477	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:43413477G>A	uc002zab.3	-	3	942	c.728C>T	c.(727-729)TCA>TTA	p.S243L	ZNF295_uc002yzz.3_Missense_Mutation_p.S243L|ZNF295_uc002yzy.3_Missense_Mutation_p.S243L|ZNF295_uc002zaa.3_Missense_Mutation_p.S243L|ZNF295_uc010gov.1_Missense_Mutation_p.S243L|ZNF295_uc002zac.2_Missense_Mutation_p.S243L	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	243					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CAGAGGCTTTGAAGGCAACAC	0.428		NaN											0	0	0	0.001855	0	14	17									
TRAPPC10	7109	broad.mit.edu	37	21	45522807	45522807	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:45522807C>T	uc002zea.2	+	22	3664	c.3495C>T	c.(3493-3495)TTC>TTT	p.F1165F	TRAPPC10_uc010gpo.2_Silent_p.F876F|TRAPPC10_uc011afa.1_Silent_p.F543F	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1165					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TCAGGCTGTTCAAGTACCTCC	0.552		NaN											0	0	0	0.01441	0	41	75									
POFUT2	23275	broad.mit.edu	37	21	46685469	46685469	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:46685469C>T	uc002zhc.2	-	9	1243	c.1218G>A	c.(1216-1218)ACG>ACA	p.T406T	POFUT2_uc002zha.2_RNA|POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_3'UTR	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	406					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		TGTTGTACGTCGTCTTGGGGT	0.527		NaN											0	0	0	0.00245	0	14	55									
MCM3AP	8888	broad.mit.edu	37	21	47704198	47704198	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr21:47704198C>A	uc002zir.1	-	1	1039	c.1003G>T	c.(1003-1005)GGT>TGT	p.G335C	C21orf57_uc002zit.1_5'Flank|C21orf57_uc002ziu.1_5'Flank|C21orf57_uc002ziv.2_5'Flank|C21orf57_uc002ziw.2_5'Flank|C21orf57_uc002zix.2_5'Flank|C21orf57_uc010gqh.2_5'Flank|C21orf57_uc002ziy.2_5'Flank	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	335					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					AATAAAGTACCTCCCCGGGGT	0.522		NaN											1	0	2.70662e-09	0.009535	2.86622e-09	33	124									
P2RX6	9127	broad.mit.edu	37	22	21380552	21380552	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:21380552C>T	uc010gsu.1	+	11	1062	c.1062C>T	c.(1060-1062)TTC>TTT	p.F354F	P2RX6_uc002ztz.2_Silent_p.F328F|P2RX6_uc002zua.2_RNA|P2RX6_uc002zuc.1_RNA	NM_005446	NP_005437	O15547	P2RX6_HUMAN	purinergic receptor P2X6 isoform 1	354	Helical; Name=2; (Potential).				muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity				0						TCACCTTTTTCTGTGACCTGC	0.463		NaN											0	0	0	0.001984	0	6	7									
CCDC116	164592	broad.mit.edu	37	22	21988323	21988323	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:21988323A>T	uc002zve.2	+	3	178	c.85A>T	c.(85-87)AAG>TAG	p.K29*	CCDC116_uc011aih.1_Nonsense_Mutation_p.K29*	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	29										ovary(1)|skin(1)	2	Colorectal(54;0.105)					GCAGCTGCCCAAGAAGCCACT	0.637		NaN											0	0	0	0.007291	0	28	75									
TOP3B	8940	broad.mit.edu	37	22	22322014	22322014	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:22322014C>T	uc002zvs.2	-	8	1248	c.813G>A	c.(811-813)CAG>CAA	p.Q271Q	TOP3B_uc010gtm.1_5'UTR|TOP3B_uc002zvr.2_5'UTR|TOP3B_uc010gtl.2_Silent_p.Q271Q|TOP3B_uc002zvt.3_Silent_p.Q271Q	NM_003935	NP_003926	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	271					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			kidney(1)	1	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TTAAAAACATCTGTGCGATCT	0.502		NaN											0	0	0	0.003271	0	31	73									
GGTLC2	91227	broad.mit.edu	37	22	22989480	22989480	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:22989480C>T	uc010gtt.2	+	3	366	c.332C>T	c.(331-333)CCG>CTG	p.P111L	LOC96610_uc011aim.1_Intron|POM121L1P_uc011ait.1_5'Flank|GGTLC2_uc010gts.2_Missense_Mutation_p.P111L	NM_199127	NP_954578	Q14390	GGTL2_HUMAN	gamma-glutamyltransferase-like 4 isoform 1	111					glutathione biosynthetic process		gamma-glutamyltransferase activity			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.3e-31)|Acute lymphoblastic leukemia(6;5.54e-23)		READ - Rectum adenocarcinoma(21;0.145)		TCAATGTGCCCGACGATCATG	0.652		NaN											0	0	0	0.003755	0	32	91									
CARD10	29775	broad.mit.edu	37	22	37887821	37887821	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:37887821G>C	uc003asx.1	-	19	2808	c.2805C>G	c.(2803-2805)AAC>AAG	p.N935K	CARD10_uc003ast.1_RNA|CARD10_uc003asu.1_5'UTR|CARD10_uc003asv.1_5'UTR|CARD10_uc011ank.1_Missense_Mutation_p.N253K|CARD10_uc003asw.1_Missense_Mutation_p.N649K|CARD10_uc003asy.1_Missense_Mutation_p.N935K	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	935					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					GGTAGATCTCGTTCTGCACCA	0.617		NaN											0	0	0	0.006214	0	7	55									
GALR3	8484	broad.mit.edu	37	22	38220829	38220829	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:38220829C>G	uc003aub.1	+	2	484	c.459C>G	c.(457-459)TTC>TTG	p.F153L		NM_003614	NP_003605	O60755	GALR3_HUMAN	galanin receptor 3	153	Helical; Name=4; (Potential).				feeding behavior|learning or memory|negative regulation of adenylate cyclase activity	integral to membrane|plasma membrane	galanin receptor activity				0	Melanoma(58;0.045)					CGGCGCTCTTCTCGGCGCCCT	0.771		NaN											0	0	0	0.000602	0	4	11									
PLA2G6	8398	broad.mit.edu	37	22	38541624	38541624	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:38541624C>T	uc003auy.1	-	3	382	c.246G>A	c.(244-246)GTG>GTA	p.V82V	PLA2G6_uc003auz.1_Silent_p.V82V|PLA2G6_uc003ava.1_Silent_p.V82V|PLA2G6_uc003avb.2_Silent_p.V82V|PLA2G6_uc010gxk.1_Intron|PLA2G6_uc011ano.1_Silent_p.V82V	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	82					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	GATGGAAATTCACTAGGGCGT	0.572		NaN											0	0	0	0.007413	0	15	36									
NPTXR	23467	broad.mit.edu	37	22	39239400	39239400	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:39239400G>A	uc003awk.2	-	1	618	c.464C>T	c.(463-465)ACC>ATC	p.T155I		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	155	Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					CAGCTTGCCGGTGAGCTCACG	0.602		NaN											0	0	0	0.004672	0	3	10									
EP300	2033	broad.mit.edu	37	22	41513289	41513289	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:41513289C>T	uc003azl.3	+	2	588	c.193C>T	c.(193-195)CAG>TAG	p.Q65*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	65	Interaction with ALX1.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TAATCAGCTTCAGACAAGTCT	0.418		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.008871	0	19	43									
TCF20	6942	broad.mit.edu	37	22	42607770	42607770	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:42607770G>A	uc003bcj.1	-	1	3676	c.3542C>T	c.(3541-3543)TCC>TTC	p.S1181F	TCF20_uc003bck.1_Missense_Mutation_p.S1181F|TCF20_uc003bnt.2_Missense_Mutation_p.S1181F	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1181	Leucine-zipper.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						TAACTTCTGGGAGCCATGCTT	0.532		NaN											0	0	0	0.010504	0	22	59									
TTLL12	23170	broad.mit.edu	37	22	43570524	43570524	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:43570524A>C	uc003bdq.2	-	7	1047	c.1015T>G	c.(1015-1017)TCA>GCA	p.S339A	TTLL12_uc003bdr.1_Missense_Mutation_p.S339A	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	339	TTL.				protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				TTGAAGTGTGAGAAGTTGAAG	0.657		NaN											0	0	0	0.010818	0	28	46									
IL17REL	400935	broad.mit.edu	37	22	50436125	50436125	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:50436125C>T	uc003bje.1	-	12	1098	c.866G>A	c.(865-867)CGT>CAT	p.R289H		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	289										pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		TGGGAAGCGACGCTGTTCGAA	0.527		NaN											0	0	0	0.003163	0	13	49									
PANX2	56666	broad.mit.edu	37	22	50609337	50609337	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:50609337C>T	uc003bjn.3	+	1	178	c.178C>T	c.(178-180)CTG>TTG	p.L60L	PANX2_uc003bjp.3_5'UTR|PANX2_uc003bjo.3_Silent_p.L60L	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	60	Helical; (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		CGGCACCGTGCTGGTGCCCAT	0.587		NaN											0	0	0	0.000602	0	4	12									
CNTN6	27255	broad.mit.edu	37	3	1445006	1445006	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:1445006G>C	uc003boz.2	+	23	3258	c.2991G>C	c.(2989-2991)TTG>TTC	p.L997F	CNTN6_uc011asj.1_Missense_Mutation_p.L925F|CNTN6_uc003bpa.2_Missense_Mutation_p.L997F	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	997					axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TTGCAGGTTTGAGTTCCAGAG	0.303		NaN											0	0	0	0.010729	0	12	40									
CRBN	51185	broad.mit.edu	37	3	3194143	3194143	+	Missense_Mutation	SNP	G	G	C	rs146272907		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:3194143G>C	uc003bpq.2	-	10	1164	c.1145C>G	c.(1144-1146)CCT>CGT	p.P382R	CRBN_uc003bpr.2_Missense_Mutation_p.P381R|CRBN_uc010hbw.2_Intron	NM_016302	NP_057386	Q96SW2	CRBN_HUMAN	cereblon	382	Thalidomide-binding.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			ovary(1)	1				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		ATATTACCCAGGAAACCAGCT	0.393		NaN											0	0	0	0.014323	0	22	37									
ITPR1	3708	broad.mit.edu	37	3	4818947	4818947	+	Splice_Site	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:4818947G>A	uc003bqa.2	+	45	6385	c.6037_splice	c.e45-1	p.N2013_splice	ITPR1_uc010hca.1_Splice_Site_p.N1998_splice|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Splice_Site_p.N983_splice	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1						activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TCTTTGCTCAGAACTGCATAG	0.448		NaN											0	0	0	0.004672	0	3	4									
ATP2B2	491	broad.mit.edu	37	3	10420033	10420033	+	Silent	SNP	G	G	A	rs147871544		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:10420033G>A	uc003bvt.2	-	10	1543	c.1104C>T	c.(1102-1104)GGC>GGT	p.G368G	ATP2B2_uc003bvv.2_Silent_p.G323G|ATP2B2_uc003bvw.2_Silent_p.G323G|ATP2B2_uc010hdo.2_Silent_p.G73G	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	368	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CGTCAGCGTCGCCGCCCTCGG	0.627		NaN											0	0	0	0.01441	0	50	72									
TIMP4	7079	broad.mit.edu	37	3	12195844	12195844	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:12195844G>A	uc003bwo.2	-	4	767	c.460C>T	c.(460-462)CTG>TTG	p.L154L	SYN2_uc003bwl.1_Intron|SYN2_uc003bwm.2_Intron|SYN2_uc003bwn.2_Intron	NM_003256	NP_003247	Q99727	TIMP4_HUMAN	tissue inhibitor of metalloproteinase 4	154	NTR.						metal ion binding|metalloendopeptidase inhibitor activity				0						CCACAGTTCAGATGGTAGTGA	0.473		NaN											0	0	0	0.01441	0	72	157									
KCNH8	131096	broad.mit.edu	37	3	19436626	19436626	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:19436626C>T	uc003cbk.1	+	7	1195	c.1000C>T	c.(1000-1002)CGC>TGC	p.R334C	KCNH8_uc011awe.1_Missense_Mutation_p.R334C|KCNH8_uc010hex.1_5'UTR|KCNH8_uc011awf.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	334	Helical; Voltage-sensor; Name=Segment S4; (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						AAAGACAGTGCGCCTCTTGCG	0.478		NaN											0	0	0	0.01441	0	45	103									
CMTM8	152189	broad.mit.edu	37	3	32280541	32280541	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:32280541G>A	uc003cex.2	+	1	371	c.77G>A	c.(76-78)AGC>AAC	p.S26N	CMTM8_uc010hfu.2_Missense_Mutation_p.S26N	NM_178868	NP_849199	Q8IZV2	CKLF8_HUMAN	CKLF-like MARVEL transmembrane domain containing	26					chemotaxis	extracellular space|integral to membrane	cytokine activity				0						TTCTCCACCAGCAGCAGCAGC	0.706		NaN											0	0	0	0.001168	0	5	6									
UBP1	7342	broad.mit.edu	37	3	33434926	33434926	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:33434926C>T	uc003cfq.3	-	14	1941	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K	FBXL2_uc011axq.1_Intron|FBXL2_uc011axr.1_Intron|UBP1_uc003cfr.3_Missense_Mutation_p.E435K|UBP1_uc010hga.2_Missense_Mutation_p.E471K	NM_014517	NP_055332	Q9NZI7	UBIP1_HUMAN	upstream binding protein 1 (LBP-1a) isoform a	471					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			kidney(2)	2						ATCATTTCTTCCAAGTAGATT	0.368		NaN											0	0	0	0.013537	0	12	32									
CLASP2	23122	broad.mit.edu	37	3	33614729	33614729	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:33614729G>A	uc003cfu.2	-	25	2926	c.2572C>T	c.(2572-2574)CCT>TCT	p.P858S	CLASP2_uc003cfs.2_Missense_Mutation_p.P66S|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.P459S	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	867										ovary(3)|central_nervous_system(1)	4						ATATATGTAGGAATACTACCA	0.433		NaN											0	0	0	0.01441	0	70	135									
DLEC1	9940	broad.mit.edu	37	3	38157986	38157986	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:38157986A>G	uc003cho.1	+	28	3920	c.3899A>G	c.(3898-3900)GAA>GGA	p.E1300G	DLEC1_uc003chp.1_Missense_Mutation_p.E1300G|DLEC1_uc010hgv.1_Missense_Mutation_p.E1303G|DLEC1_uc003chr.1_Missense_Mutation_p.E371G|DLEC1_uc010hgx.1_RNA|DLEC1_uc003chs.1_5'Flank	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	1300					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GAAGACAAGGAAGACCGGCTG	0.607		NaN											0	0	0	0.004656	0	18	50									
TTC21A	199223	broad.mit.edu	37	3	39166997	39166997	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:39166997G>A	uc003cjc.2	+	11	1567	c.1390G>A	c.(1390-1392)GAG>AAG	p.E464K	TTC21A_uc003cje.2_Missense_Mutation_p.E464K|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.E415K	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	464							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CATTGCTAAGGAGTACTTGCT	0.552		NaN											0	0	0	0.013726	0	28	96									
ULK4	54986	broad.mit.edu	37	3	41831325	41831325	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:41831325C>T	uc003ckv.3	-	21	2222	c.2021G>A	c.(2020-2022)AGA>AAA	p.R674K	ULK4_uc003ckw.2_Missense_Mutation_p.R674K	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	674							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GCGAGTGATTCTACACAAGGC	0.463		NaN											0	0	0	0.014323	0	20	43									
DHX30	22907	broad.mit.edu	37	3	47883135	47883135	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:47883135G>A	uc003cru.2	+	8	1123	c.697G>A	c.(697-699)GAC>AAC	p.D233N	DHX30_uc003crs.2_Missense_Mutation_p.D194N|DHX30_uc003crt.2_Missense_Mutation_p.D194N|DHX30_uc010hjr.1_Missense_Mutation_p.D261N	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	233						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		GACAGATGACGACAGTGCCAT	0.493		NaN											0	0	0	0.00632	0	30	54									
RBM6	10180	broad.mit.edu	37	3	50012766	50012766	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:50012766C>T	uc003cyc.2	+	5	1557	c.1424C>T	c.(1423-1425)GCT>GTT	p.A475V	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_5'UTR|RBM6_uc003cyd.2_5'UTR|RBM6_uc003cye.2_Intron|RBM6_uc011bdi.1_Intron|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_Intron	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	475	RRM.				RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		ATTCTTAATGCTTTTCGGACT	0.358		NaN											0	0	0	0.014323	0	22	59									
RBM5	10181	broad.mit.edu	37	3	50145531	50145531	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:50145531A>G	uc003cyg.2	+	13	1218	c.1070A>G	c.(1069-1071)GAC>GGC	p.D357G	RBM5_uc011bdj.1_Missense_Mutation_p.D301G|RBM5_uc011bdk.1_Missense_Mutation_p.D185G	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	357	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGCAGTGTTGACTACAGTTAT	0.403		NaN											0	0	0	0.012319	0	19	28									
MAPKAPK3	7867	broad.mit.edu	37	3	50685459	50685459	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:50685459G>A	uc003day.1	+	13	1727	c.1131G>A	c.(1129-1131)CAG>CAA	p.Q377Q	MAPKAPK3_uc003daz.1_Silent_p.Q377Q|MAPKAPK3_uc003dba.1_Silent_p.Q377Q|MAPKAPK3_uc010hlr.1_Silent_p.Q377Q	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	377					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		CTGCCTCACAGGGCTGCAACA	0.572		NaN											0	0	0	0.008291	0	11	43									
VPRBP	9730	broad.mit.edu	37	3	51464860	51464860	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:51464860T>G	uc003dbe.1	-	12	1978	c.1810A>C	c.(1810-1812)ATT>CTT	p.I604L		NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	604					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		GCAATAGAAATAAGCTGCAAC	0.388		NaN											0	0	0	0.00278	0	20	35									
ITIH1	3697	broad.mit.edu	37	3	52812034	52812034	+	Splice_Site	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:52812034G>T	uc003dfs.2	+	2	162	c.138_splice	c.e2+1	p.T46_splice	ITIH1_uc010hmn.1_Splice_Site	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1						hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TGTGGACACCGTGAGTAAGAG	0.562		NaN											1	0	1.22674e-20	0.00874	1.32679e-20	33	71									
PDE12	201626	broad.mit.edu	37	3	57545080	57545080	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:57545080G>A	uc003diw.3	+	2	1478	c.1352G>A	c.(1351-1353)TGT>TAT	p.C451Y	PDE12_uc003div.2_Missense_Mutation_p.C451Y	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	451							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		AAAAGGATATGTGTTGCTAAT	0.358		NaN											0	0	0	0.001855	0	13	67									
MAGI1	9223	broad.mit.edu	37	3	65346992	65346992	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:65346992C>T	uc003dmn.2	-	22	4042	c.3516G>A	c.(3514-3516)GAG>GAA	p.E1172E	MAGI1_uc003dmm.2_Silent_p.E1200E|MAGI1_uc003dmo.2_Silent_p.E1201E|MAGI1_uc003dmp.2_Silent_p.E1105E	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	1201	PDZ 6.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CACCATTGATCTCTAAAATTT	0.348		NaN											0	0	0	0.012319	0	21	30									
SHQ1	55164	broad.mit.edu	37	3	72799820	72799820	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:72799820G>A	uc003dpf.2	-	11	1456	c.1349C>T	c.(1348-1350)TCC>TTC	p.S450F	SHQ1_uc010hod.2_Missense_Mutation_p.S361F	NM_018130	NP_060600	Q6PI26	SHQ1_HUMAN	SHQ1 homolog	450	Ser-rich.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		CTCAGAGCTGGAGCAAAGTGT	0.478		NaN											0	0	0	0.004482	0	9	6									
SHQ1	55164	broad.mit.edu	37	3	72897392	72897392	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:72897392C>T	uc003dpf.2	-	1	207	c.100G>A	c.(100-102)GAG>AAG	p.E34K	SHQ1_uc010hod.2_5'UTR	NM_018130	NP_060600	Q6PI26	SHQ1_HUMAN	SHQ1 homolog	34	CS.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			ovary(2)|large_intestine(1)	3		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		TCAGACCCCTCGAAGTAGACG	0.592		NaN											0	0	0	0.01441	0	73	139									
CNTN3	5067	broad.mit.edu	37	3	74350557	74350557	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:74350557T>C	uc003dpm.1	-	15	2167	c.2087A>G	c.(2086-2088)GAA>GGA	p.E696G		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	696					cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		ACCTGCCTCTTCAGTTCTTAC	0.433		NaN											0	0	0	0.014323	0	19	62									
CNTN3	5067	broad.mit.edu	37	3	74350587	74350587	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:74350587G>T	uc003dpm.1	-	15	2137	c.2057C>A	c.(2056-2058)CCA>CAA	p.P686Q		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	686	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GGGTAAACTTGGTTCTCCACC	0.408		NaN											1	0	1.33834e-09	0.007413	1.419e-09	17	75									
EPHA6	285220	broad.mit.edu	37	3	96706689	96706689	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:96706689T>C	uc010how.1	+	3	1009	c.966T>C	c.(964-966)TCT>TCC	p.S322S	EPHA6_uc003drp.1_Silent_p.S322S	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	227	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						ATTCCTCCTCTTTGGTTGAAG	0.473		NaN											0	0	0	0.01441	0	56	128									
MORC1	27136	broad.mit.edu	37	3	108690187	108690187	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:108690187A>G	uc003dxl.2	-	25	2627	c.2540T>C	c.(2539-2541)TTA>TCA	p.L847S	MORC1_uc011bhn.1_Missense_Mutation_p.L826S	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	847					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CTCACAACTTAATGCAGGTTC	0.383		NaN											0	0	0	0.008361	0	28	76									
TMPRSS7	344805	broad.mit.edu	37	3	111785291	111785291	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:111785291C>T	uc010hqb.2	+	11	1400	c.1230C>T	c.(1228-1230)CTC>CTT	p.L410L	TMPRSS7_uc011bhr.1_Silent_p.L265L	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	536	Extracellular (Potential).|LDL-receptor class A 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						ATGGCCCTCTCATCTGTGATG	0.507		NaN											0	0	0	0.00623	0	32	232									
TMPRSS7	344805	broad.mit.edu	37	3	111794272	111794272	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:111794272T>C	uc010hqb.2	+	13	1680	c.1510T>C	c.(1510-1512)TAC>CAC	p.Y504H	TMPRSS7_uc011bhr.1_Missense_Mutation_p.Y359H	NM_001042575	NP_001036040	Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	630	Extracellular (Potential).|Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			ovary(1)|kidney(1)	2						TGGATCTGCCTACTGTGGTGC	0.582		NaN											0	0	0	0.01441	0	63	489									
BOC	91653	broad.mit.edu	37	3	113003353	113003353	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:113003353C>T	uc003dzx.2	+	17	3446	c.2825C>T	c.(2824-2826)TCG>TTG	p.S942L	BOC_uc003dzy.2_Missense_Mutation_p.S942L|BOC_uc003dzz.2_Missense_Mutation_p.S943L|BOC_uc003eab.2_Missense_Mutation_p.S643L|BOC_uc003eac.2_Missense_Mutation_p.S257L	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	942	Cytoplasmic (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			GGCTGCCCCTCGGCTGCAGTG	0.647		NaN											0	0	0	0.009718	0	43	37									
GOLGB1	2804	broad.mit.edu	37	3	121411211	121411211	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:121411211C>T	uc003eei.3	-	14	7111	c.6985G>A	c.(6985-6987)GAA>AAA	p.E2329K	GOLGB1_uc010hrc.2_Missense_Mutation_p.E2334K|GOLGB1_uc003eej.3_Missense_Mutation_p.E2295K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2329	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTACATTTTTCTAAAGAGTTA	0.373		NaN											0	0	0	0.010818	0	29	156									
GOLGB1	2804	broad.mit.edu	37	3	121415253	121415253	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:121415253C>T	uc003eei.3	-	13	4228	c.4102G>A	c.(4102-4104)GAA>AAA	p.E1368K	GOLGB1_uc010hrc.2_Missense_Mutation_p.E1373K|GOLGB1_uc003eej.3_Missense_Mutation_p.E1334K|GOLGB1_uc011bjm.1_Missense_Mutation_p.E1254K|GOLGB1_uc010hrd.1_Missense_Mutation_p.E1332K	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1368	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGCAGGCTTTCGGCATGGACT	0.398		NaN											0	0	0	0.01441	0	288	141									
ITGB5	3693	broad.mit.edu	37	3	124487931	124487931	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:124487931G>A	uc003eho.2	-	12	2243	c.1946C>T	c.(1945-1947)TCT>TTT	p.S649F	ITGB5_uc010hrx.2_RNA	NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	649	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		AGGTTTCCCAGAGTGGAGCAG	0.557		NaN											0	0	0	0.01441	0	138	46									
ZNF148	7707	broad.mit.edu	37	3	124952081	124952081	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:124952081G>A	uc003ehx.3	-	9	1975	c.1489C>T	c.(1489-1491)CAG>TAG	p.Q497*	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Nonsense_Mutation_p.Q497*|ZNF148_uc010hsa.2_Nonsense_Mutation_p.Q497*|ZNF148_uc003eia.3_Nonsense_Mutation_p.Q497*|ZNF148_uc003ehy.2_Intron	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	497					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						ACAGAAGGCTGAGAAGCTATG	0.438		NaN											0	0	0	0.01441	0	192	83									
PLXNA1	5361	broad.mit.edu	37	3	126724992	126724992	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:126724992C>T	uc003ejg.2	+	7	1903	c.1899C>T	c.(1897-1899)TTC>TTT	p.F633F		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	656	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CTGTGGACTTCGTCTTCTACA	0.607		NaN											0	0	0	0.010504	0	22	176									
PLXNA1	5361	broad.mit.edu	37	3	126735421	126735421	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:126735421A>G	uc003ejg.2	+	15	3011	c.3007A>G	c.(3007-3009)ATC>GTC	p.I1003V		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1026	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGCGCTCCCATCATCATCAA	0.632		NaN											0	0	0	0.006122	0	15	216									
EEFSEC	60678	broad.mit.edu	37	3	128060247	128060247	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:128060247G>A	uc003eki.2	+	5	996	c.958G>A	c.(958-960)GAA>AAA	p.E320K	EEFSEC_uc003ekj.2_Missense_Mutation_p.E265K	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	320						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						CATCTCTGTGGAAAAGATACC	0.582		NaN											0	0	0	0.01441	0	56	254									
PIK3R4	30849	broad.mit.edu	37	3	130405056	130405056	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:130405056A>G	uc003enj.2	-	15	4055	c.3474T>C	c.(3472-3474)ATT>ATC	p.I1158I		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1158	WD 4.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						TTAGCTTACCAATGCAGAGCC	0.428		NaN											0	0	0	0.005443	0	25	25									
ACPP	55	broad.mit.edu	37	3	132071660	132071660	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:132071660G>A	uc010htp.2	+	9	1051	c.961G>A	c.(961-963)GAG>AAG	p.E321K	ACPP_uc003eon.3_Missense_Mutation_p.E288K|ACPP_uc003eop.3_Missense_Mutation_p.E321K	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	321						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						ATTGTACTTTGAGAAGGGGTA	0.433		NaN											0	0	0	0.001855	0	14	29									
CCRL1	51554	broad.mit.edu	37	3	132319410	132319410	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:132319410G>A	uc003eow.2	+	2	252	c.169G>A	c.(169-171)GCA>ACA	p.A57T	ACAD11_uc003eov.3_Intron|ACAD11_uc011blr.1_Intron|CCRL1_uc003eox.2_Missense_Mutation_p.A57T	NM_016557	NP_057641	Q9NPB9	CCRL1_HUMAN	chemokine (C-C motif) receptor-like 1	57	Helical; Name=1; (Potential).				chemotaxis|immune response	integral to plasma membrane	C-C chemokine receptor activity				0						CATTGGACTTGCAGGCAATTC	0.383		NaN											0	0	0	0.003954	0	20	23									
TOPBP1	11073	broad.mit.edu	37	3	133339155	133339155	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:133339155T>G	uc003eps.2	-	20	3347	c.3215A>C	c.(3214-3216)CAG>CCG	p.Q1072P	TOPBP1_uc003ept.1_Missense_Mutation_p.Q76P	NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	1072					DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						TAACTGCTTCTGAAAGTTCTC	0.398		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.004289	0	32	19									
NCK1	4690	broad.mit.edu	37	3	136667120	136667120	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:136667120C>T	uc003erh.2	+	4	1066	c.959C>T	c.(958-960)TCA>TTA	p.S320L	NCK1_uc011bme.1_Missense_Mutation_p.S256L	NM_006153	NP_006144	P16333	NCK1_HUMAN	NCK adaptor protein 1	320	SH2.				axon guidance|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of translation|signal complex assembly|T cell activation|T cell receptor signaling pathway	cytosol|endoplasmic reticulum|nucleus	cytoskeletal adaptor activity|receptor binding|receptor signaling complex scaffold activity			pancreas(1)	1						TTCTCAGTATCACTAAAAGCA	0.308		NaN											0	0	0	0.013537	0	10	18									
RAP2B	5912	broad.mit.edu	37	3	152880938	152880938	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:152880938G>A	uc003ezr.2	+	1	910	c.456G>A	c.(454-456)TCG>TCA	p.S152S		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	152					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			ACAAAGCCTCGGTAGACGAGC	0.642		NaN											0	0	0	0.000602	0	5	9									
RPL22L1	200916	broad.mit.edu	37	3	170584195	170584195	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:170584195C>T	uc003fhc.3	-	4	432	c.343G>A	c.(343-345)GAA>AAA	p.E115K	RPL22L1_uc003fhb.3_RNA	NM_001099645	NP_001093115	Q6P5R6	RL22L_HUMAN	ribosomal protein L22-like 1	115					translation	ribosome	structural constituent of ribosome				0	all_cancers(22;1.96e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.137)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GATTCATCTTCATCTTGACTA	0.393		NaN											0	0	0	0.000602	0	4	22									
SLC2A2	6514	broad.mit.edu	37	3	170727792	170727792	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:170727792G>C	uc003fhe.1	-	4	760	c.451C>G	c.(451-453)CAT>GAT	p.H151D	SLC2A2_uc003fhf.1_Intron|SLC2A2_uc011bpu.1_Missense_Mutation_p.H24D	NM_000340	NP_000331	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose	151	Extracellular (Potential).				carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			ATAAGTATATGAGATGGTCCC	0.289		NaN											0	0	0	0.001855	0	14	24									
NCEH1	57552	broad.mit.edu	37	3	172365740	172365740	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:172365740G>C	uc011bpx.1	-	2	537	c.399C>G	c.(397-399)CCC>CCG	p.P133P	NCEH1_uc003fig.2_Silent_p.P133P|NCEH1_uc011bpw.1_5'UTR|NCEH1_uc011bpy.1_Intron	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	101	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						GTGGCTCTTCGGGCTTCGGAG	0.532		NaN											0	0	0	0.00499	0	16	46									
GNB4	59345	broad.mit.edu	37	3	179119064	179119064	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:179119064T>C	uc003fjv.3	-	10	1240	c.960A>G	c.(958-960)GTA>GTG	p.V320V	GNB4_uc003fju.3_3'UTR	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	320	WD 7.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)			CATCATCAGTTACACCTAAGC	0.383		NaN											0	0	0	0.014323	0	20	29									
FXR1	8087	broad.mit.edu	37	3	180630521	180630521	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:180630521C>T	uc003fkq.2	+	1	70	c.48C>T	c.(46-48)TAC>TAT	p.Y16Y	FXR1_uc003fkp.2_5'UTR|FXR1_uc003fkr.2_Silent_p.Y16Y|FXR1_uc011bqj.1_5'UTR|FXR1_uc003fks.2_5'UTR|FXR1_uc011bqk.1_Silent_p.Y16Y|FXR1_uc011bql.1_5'Flank	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	16					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GGGCTTTCTACAAGGTACTGA	0.552		NaN									OREG0015934	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	57	113									
KLHL6	89857	broad.mit.edu	37	3	183209963	183209963	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:183209963G>A	uc003flr.2	-	7	1676	c.1618C>T	c.(1618-1620)CTG>TTG	p.L540L	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	540	Kelch 5.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			TGGGTCACCAGGCACCAGCTG	0.632		NaN											0	0	0	0.00333	0	26	33									
ABCC5	10057	broad.mit.edu	37	3	183665178	183665178	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:183665178C>T	uc003fmg.2	-	23	3513	c.3348G>A	c.(3346-3348)ATG>ATA	p.M1116I	ABCC5_uc011bqt.1_Missense_Mutation_p.M644I|ABCC5_uc010hxl.2_Missense_Mutation_p.M1073I	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1116	Helical; (Potential).|ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TAAGAACGATCATCAGCCCCG	0.552		NaN											0	0	0	0.00499	0	16	23									
CHRD	8646	broad.mit.edu	37	3	184099561	184099561	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:184099561C>T	uc003fov.2	+	5	815	c.569C>T	c.(568-570)TCG>TTG	p.S190L	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Missense_Mutation_p.S190L|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'Flank	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	190	CHRD 1.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCCGAGTCTCGCTGCTGCGC	0.662		NaN											0	0	0	0.00245	0	13	26									
VPS8	23355	broad.mit.edu	37	3	184612519	184612519	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:184612519A>G	uc003fpb.1	+	22	1975	c.1804A>G	c.(1804-1806)AAA>GAA	p.K602E	VPS8_uc010hyd.1_Intron|VPS8_uc010hye.1_Missense_Mutation_p.K31E	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	604							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GATGTATGATAAATTAAGTGA	0.353		NaN											0	0	0	0.009096	0	3	14									
OPA1	4976	broad.mit.edu	37	3	193372785	193372785	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:193372785C>T	uc003ftm.2	+	20	2216	c.1982C>T	c.(1981-1983)ACT>ATT	p.T661I	OPA1_uc003ftg.2_Missense_Mutation_p.T716I|OPA1_uc003fth.2_Missense_Mutation_p.T680I|OPA1_uc003fti.2_Missense_Mutation_p.T698I|OPA1_uc003ftj.2_Missense_Mutation_p.T679I|OPA1_uc003ftk.2_Missense_Mutation_p.T662I|OPA1_uc003ftl.2_Missense_Mutation_p.T643I|OPA1_uc003ftn.2_Missense_Mutation_p.T625I	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	661	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		AAACAGTGGACTGATAAACAA	0.368		NaN											0	0	0	0.008871	0	14	27									
ZNF595	152687	broad.mit.edu	37	4	86807	86807	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:86807G>T	uc003fzv.1	+	6	1569	c.1413G>T	c.(1411-1413)AAG>AAT	p.K471N	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.K239N|ZNF595_uc011but.1_Missense_Mutation_p.K239N	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	471					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		ACGAACATAAGAAAATTCATA	0.388		NaN											1	0	0.00024832	0.009096	0.000257894	4	19									
ZNF595	152687	broad.mit.edu	37	4	87051	87051	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:87051G>C	uc003fzv.1	+	6	1813	c.1657G>C	c.(1657-1659)GAA>CAA	p.E553Q	ZNF595_uc003fzu.1_Intron|ZNF718_uc003fzt.3_Intron|ZNF595_uc011bus.1_Missense_Mutation_p.E321Q|ZNF595_uc011but.1_Missense_Mutation_p.E321Q	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	553					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		AGCCCTGAATGAACATAAGAA	0.378		NaN											0	0	0	0.008291	0	10	33									
FAM193A	8603	broad.mit.edu	37	4	2664635	2664635	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:2664635G>A	uc010icl.2	+	9	1294	c.943G>A	c.(943-945)GAT>AAT	p.D315N	FAM193A_uc010ick.2_Missense_Mutation_p.D515N|FAM193A_uc003gfd.2_Missense_Mutation_p.D315N|FAM193A_uc011bvm.1_Missense_Mutation_p.D337N|FAM193A_uc011bvn.1_Missense_Mutation_p.D315N|FAM193A_uc011bvo.1_RNA|FAM193A_uc010icm.2_RNA|FAM193A_uc003gfe.2_Missense_Mutation_p.D169N	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603	315										ovary(3)	3						GAGTAATTATGATGATACCGA	0.453		NaN											0	0	0	0.006122	0	18	45									
JAKMIP1	152789	broad.mit.edu	37	4	6107461	6107461	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:6107461G>A	uc003giu.3	-	3	639	c.363C>T	c.(361-363)CGC>CGT	p.R121R	JAKMIP1_uc010idb.1_Silent_p.R121R|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Silent_p.R121R|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Silent_p.R121R|JAKMIP1_uc010ide.2_Silent_p.R121R	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	121	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						CCGCGCCGTCGCGCAGCACGT	0.726		NaN											0	0	0	0.001984	0	6	11									
ABLIM2	84448	broad.mit.edu	37	4	8021986	8021986	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:8021986C>T	uc003gko.2	-	12	1356	c.1213G>A	c.(1213-1215)GAC>AAC	p.D405N	ABLIM2_uc003gkk.2_Missense_Mutation_p.D68N|ABLIM2_uc003gkl.2_Intron|ABLIM2_uc003gkj.3_Missense_Mutation_p.D438N|ABLIM2_uc003gkm.3_Intron|ABLIM2_uc003gkp.2_Intron|ABLIM2_uc003gkq.2_Missense_Mutation_p.D405N|ABLIM2_uc003gkr.2_Intron|ABLIM2_uc003gks.3_Intron	NM_001130084	NP_001123556	Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	405					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			pancreas(3)	3						GGCTTGCTGTCAGAGAGCACG	0.622		NaN											0	0	0	0.001984	0	7	27									
FAM114A1	92689	broad.mit.edu	37	4	38916603	38916603	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:38916603G>C	uc003gtn.2	+	8	1030	c.854G>C	c.(853-855)AGA>ACA	p.R285T	FAM114A1_uc011byh.1_Missense_Mutation_p.R78T	NM_138389	NP_612398	Q8IWE2	NXP20_HUMAN	hypothetical protein LOC92689	285						cytoplasm				ovary(1)	1						ACGATGGAGAGAACCGCGCAC	0.468		NaN											0	0	0	0.00245	0	13	21									
N4BP2	55728	broad.mit.edu	37	4	40104102	40104102	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:40104102A>C	uc003guy.3	+	4	975	c.637A>C	c.(637-639)AAC>CAC	p.N213H	N4BP2_uc010ifq.2_Missense_Mutation_p.N133H|N4BP2_uc010ifr.2_Missense_Mutation_p.N133H	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	213						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TTTAAGTTTAAACCCATTACC	0.328		NaN											0	0	0	0.006214	0	10	19									
UGT2A3	79799	broad.mit.edu	37	4	69796299	69796299	+	Missense_Mutation	SNP	T	T	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:69796299T>G	uc003hef.2	-	5	1300	c.1269A>C	c.(1267-1269)TTA>TTC	p.L423F	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	423	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						AAGCCCTCAGTAAATCTTCGC	0.383		NaN											0	0	0	0.001855	0	13	71									
UGT2B7	7364	broad.mit.edu	37	4	69962754	69962754	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:69962754C>T	uc003heg.3	+	1	562	c.516C>T	c.(514-516)CTC>CTT	p.L172L	UGT2B7_uc010ihq.2_Silent_p.L172L	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	172					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TGTACAGTCTCAGCTTCTCTC	0.398		NaN											0	0	0	0.008871	0	19	65									
FRAS1	80144	broad.mit.edu	37	4	79430001	79430001	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:79430001C>T	uc003hlb.2	+	63	10061	c.9621C>T	c.(9619-9621)CCC>CCT	p.P3207P	FRAS1_uc003hlc.1_Silent_p.P209P	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3202	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CTCATTTCCCCAGATACGCTG	0.572		NaN											0	0	0	0.009096	0	4	13									
FRAS1	80144	broad.mit.edu	37	4	79430151	79430151	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:79430151C>T	uc003hlb.2	+	63	10211	c.9771C>T	c.(9769-9771)GTC>GTT	p.V3257V	FRAS1_uc003hlc.1_Silent_p.V259V	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3252	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TCACCAGTGTCAACCACATGG	0.532		NaN											0	0	0	0.001855	0	12	48									
TIGD2	166815	broad.mit.edu	37	4	90034836	90034836	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:90034836C>T	uc003hsk.2	+	1	869	c.711C>T	c.(709-711)TTC>TTT	p.F237F	FAM13A_uc003hsh.1_5'Flank	NM_145715	NP_663761	Q4W5G0	TIGD2_HUMAN	tigger transposable element derived 2	237	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.86e-05)		CCCGAGCATTCAAAGGCACTG	0.418		NaN											0	0	0	0.006214	0	10	32									
BMPR1B	658	broad.mit.edu	37	4	96045003	96045003	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:96045003C>T	uc003htm.3	+	7	666	c.392C>T	c.(391-393)TCT>TTT	p.S131F	BMPR1B_uc010ilb.2_Missense_Mutation_p.S131F|BMPR1B_uc003htn.3_Missense_Mutation_p.S131F	NM_001203	NP_001194	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	131	Helical; (Potential).				BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			lung(4)|skin(2)|stomach(1)|breast(1)	8		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		TTACTTATATCTGTGACTGTC	0.294		NaN											0	0	0	0.004289	0	30	71									
ADH4	127	broad.mit.edu	37	4	100047780	100047780	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:100047780G>A	uc003hun.2	-	8	1159	c.1083C>T	c.(1081-1083)ATC>ATT	p.I361I	uc003hum.1_Intron|ADH4_uc011ced.1_Silent_p.I380I	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	361					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	ATGCCTCACTGATTTTGTCAA	0.353		NaN											0	0	0	0.014323	0	17	46									
PPP3CA	5530	broad.mit.edu	37	4	101947192	101947192	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:101947192T>C	uc011cen.1	-	14	2071	c.1396A>G	c.(1396-1398)AAG>GAG	p.K466E	PPP3CA_uc003hvu.2_Missense_Mutation_p.K456E|PPP3CA_uc010ilj.2_Missense_Mutation_p.K414E|PPP3CA_uc003hvt.2_Missense_Mutation_p.K443E|PPP3CA_uc003hvs.2_Missense_Mutation_p.K399E|PPP3CA_uc010ilk.2_Missense_Mutation_p.K234E	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	466	Inhibitory domain.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		CTAGTGATCTTATGTTGTGGT	0.443		NaN											0	0	0	0.004007	0	14	42									
NFKB1	4790	broad.mit.edu	37	4	103534637	103534637	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:103534637C>T	uc011ceq.1	+	23	3112	c.2645C>T	c.(2644-2646)ACC>ATC	p.T882I	NFKB1_uc011cep.1_Missense_Mutation_p.T883I|NFKB1_uc011cer.1_Missense_Mutation_p.T702I	NM_003998	NP_003989	P19838	NFKB1_HUMAN	nuclear factor kappa-B, subunit 1 isoform 1	882	Death.|Interaction with CFLAR.				anti-apoptosis|apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|nerve growth factor receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter	cytosol|I-kappaB/NF-kappaB complex|mitochondrion|nucleoplasm	protein binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|breast(2)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.59e-08)	Dexamethasone(DB01234)|Pranlukast(DB01411)|Thalidomide(DB01041)	ATGGGCTACACCGAAGCAATT	0.562		NaN											0	0	0	0.009096	0	4	27									
GAR1	54433	broad.mit.edu	37	4	110737358	110737358	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:110737358G>C	uc003hzt.2	+	2	345	c.38G>C	c.(37-39)CGA>CCA	p.R13P	GAR1_uc003hzu.2_Missense_Mutation_p.R13P|GAR1_uc010imh.1_Missense_Mutation_p.R13P|GAR1_uc010imi.2_Missense_Mutation_p.R13P	NM_018983	NP_061856	Q9NY12	GAR1_HUMAN	nucleolar protein family A, member 1	13	RGG-box 1.				rRNA processing|snRNA pseudouridine synthesis	box H/ACA snoRNP complex|Cajal body	cation channel activity|pseudouridine synthase activity|snoRNA binding				0						GGCTTTAATCGAggtggtgga	0.234		NaN											0	0	0	0.012319	0	22	44									
NAA15	80155	broad.mit.edu	37	4	140299923	140299923	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:140299923G>A	uc003ihu.1	+	17	2326	c.2070G>A	c.(2068-2070)TTG>TTA	p.L690L		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	690	TPR 8.				angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						AGTTTCTTTTGATGCTACAAT	0.338		NaN											0	0	0	0.013537	0	13	30									
PRMT10	90826	broad.mit.edu	37	4	148605049	148605049	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:148605049C>T	uc003ilc.2	-	1	232	c.90G>A	c.(88-90)CAG>CAA	p.Q30Q	PRMT10_uc003ild.2_5'UTR	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	30	TPR 1.					cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						GCTCTGCGCTCTGCAAGGACC	0.692		NaN											0	0	0	0.00245	0	15	34									
DCHS2	54798	broad.mit.edu	37	4	155305519	155305519	+	Splice_Site	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:155305519C>T	uc003inw.2	-	2	234	c.234_splice	c.e2+1	p.E78_splice	DCHS2_uc003inx.2_Intron	NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		actgacctcacctcagtttcc	0		NaN											0	0	0	0.00245	0	11	32									
FGB	2244	broad.mit.edu	37	4	155487699	155487699	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:155487699C>A	uc003ioa.3	+	3	404	c.365C>A	c.(364-366)CCA>CAA	p.P122Q	FGB_uc010ipu.1_RNA|FGB_uc003iob.3_Missense_Mutation_p.P119Q|FGB_uc010ipv.2_Missense_Mutation_p.P60Q|FGB_uc010ipw.2_Missense_Mutation_p.P119Q|FGB_uc003ioc.3_Intron	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	122					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	CAGGAAAGGCCAATCAGAAAT	0.418		NaN											1	0	0.000308642	0.003163	0.000319004	15	34									
FNIP2	57600	broad.mit.edu	37	4	159747136	159747136	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:159747136G>A	uc003iqe.3	+	2	359	c.176G>A	c.(175-177)GGC>GAC	p.G59D	FNIP2_uc003iqd.2_Missense_Mutation_p.G59D	NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	59					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		GACAGGAGAGGCAGACAAGTC	0.413		NaN											0	0	0	0.003755	0	36	81									
FSTL5	56884	broad.mit.edu	37	4	162697045	162697045	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:162697045A>C	uc003iqh.2	-	5	1027	c.591T>G	c.(589-591)ATT>ATG	p.I197M	FSTL5_uc003iqi.2_Missense_Mutation_p.I196M|FSTL5_uc010iqv.2_Missense_Mutation_p.I196M	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	197	1 (Potential).|EF-hand 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTAGTTCATTAATATCTACAA	0.289		NaN											0	0	0	0.000602	0	4	27									
NPY1R	4886	broad.mit.edu	37	4	164246583	164246583	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:164246583G>C	uc003iqm.1	-	3	1293	c.1027C>G	c.(1027-1029)CGG>GGG	p.R343G	NPY1R_uc011cjj.1_Missense_Mutation_p.R100G	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	343	Cytoplasmic (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCATCATCCCGAGACCGGAAA	0.393		NaN											0	0	0	0.007413	0	20	54									
TRIM60	166655	broad.mit.edu	37	4	165961621	165961621	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:165961621A>G	uc003iqy.1	+	3	567	c.397A>G	c.(397-399)ATT>GTT	p.I133V	TRIM60_uc010iqx.1_Missense_Mutation_p.I133V	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	133	B box-type.					intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		CATTTGCCCTATTAAGAAAGC	0.398		NaN											0	0	0	0.010729	0	11	26									
SPOCK3	50859	broad.mit.edu	37	4	167921549	167921549	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:167921549G>A	uc003iri.1	-	5	451	c.310C>T	c.(310-312)CAA>TAA	p.Q104*	SPOCK3_uc011cjp.1_Nonsense_Mutation_p.Q101*|SPOCK3_uc011cjq.1_Nonsense_Mutation_p.Q113*|SPOCK3_uc011cjr.1_Intron|SPOCK3_uc003irj.1_Nonsense_Mutation_p.Q101*|SPOCK3_uc011cjs.1_Nonsense_Mutation_p.Q53*|SPOCK3_uc011cjt.1_Nonsense_Mutation_p.Q12*|SPOCK3_uc011cju.1_Intron|SPOCK3_uc011cjv.1_Intron|SPOCK3_uc003irk.3_Nonsense_Mutation_p.Q101*|SPOCK3_uc011cjw.1_RNA	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	104					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		TGAGAATCTTGAGCAATGCAT	0.378		NaN											0	0	0	0.010504	0	19	33									
DDX60L	91351	broad.mit.edu	37	4	169296610	169296610	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:169296610C>T	uc003irq.3	-	34	4772	c.4551G>A	c.(4549-4551)ATG>ATA	p.M1517I		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1517							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CAAAATCCTTCATTACTGCCA	0.408		NaN											0	0	0	0.000602	0	4	14									
ODZ3	55714	broad.mit.edu	37	4	183267957	183267957	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:183267957A>G	uc003ivd.1	+	2	423	c.386A>G	c.(385-387)GAG>GGG	p.E129G	ODZ3_uc010irv.1_Missense_Mutation_p.E129G	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	129	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		ATGTCCCCAGAGCATGCCATG	0.557		NaN											0	0	0	0.001984	0	7	6									
FAT1	2195	broad.mit.edu	37	4	187628629	187628629	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr4:187628629T>C	uc003izf.2	-	2	2541	c.2353A>G	c.(2353-2355)ACA>GCA	p.T785A	FAT1_uc010iso.1_Missense_Mutation_p.T785A	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	785	Extracellular (Potential).|Cadherin 6.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TATTTGTCTGTTGTTTCACGG	0.433		NaN								HNSCC(5;0.00058)			0	0	0	0.004656	0	26	85									
KIAA0947	23379	broad.mit.edu	37	5	5460633	5460633	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:5460633G>A	uc003jdm.3	+	13	1408	c.1186G>A	c.(1186-1188)GAT>AAT	p.D396N		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	396										ovary(1)|central_nervous_system(1)	2						TTCAGAAGATGATACAACTGA	0.373		NaN											0	0	0	0.009096	0	4	6									
RICTOR	253260	broad.mit.edu	37	5	38963033	38963033	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:38963033G>C	uc003jlp.2	-	17	1535	c.1511C>G	c.(1510-1512)ACA>AGA	p.T504R	RICTOR_uc003jlo.2_Missense_Mutation_p.T504R|RICTOR_uc010ivf.2_Missense_Mutation_p.T219R	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	504					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTTCTGGTGTGTTGCAATTGC	0.368		NaN											0	0	0	0.014323	0	21	33									
SLC38A9	153129	broad.mit.edu	37	5	54922436	54922436	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:54922436G>A	uc003jqf.2	-	16	1773	c.1572C>T	c.(1570-1572)CTC>CTT	p.L524L	SLC38A9_uc003jqd.2_Silent_p.L461L|SLC38A9_uc010ivx.2_Silent_p.L461L|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Silent_p.L395L	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	524	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				TTATATAGATGAGAGATGGGT	0.398		NaN											0	0	0	0.004289	0	32	58									
F2R	2149	broad.mit.edu	37	5	76028967	76028967	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:76028967G>T	uc003ken.3	+	2	1182	c.917G>T	c.(916-918)AGC>ATC	p.S306I		NM_001992	NP_001983	P25116	PAR1_HUMAN	coagulation factor II receptor precursor	306	Cytoplasmic (Potential).				activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			ovary(3)	3		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	GCCAACCGCAGCAAGAAGTCC	0.488		NaN											1	0	1.17739e-12	0.005443	1.26233e-12	28	31									
ARSK	153642	broad.mit.edu	37	5	94891054	94891054	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:94891054G>A	uc003kld.2	+	1	230	c.72G>A	c.(70-72)CAG>CAA	p.Q24Q	ARSK_uc010jbg.2_5'UTR|ARSK_uc011cum.1_RNA|TTC37_uc003klb.2_5'Flank|TTC37_uc010jbf.1_5'Flank|ARSK_uc003klc.2_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	24						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		CAGGGGAGCAGAGGCGGAGAG	0.697		NaN											0	0	0	0.001168	0	6	20									
CHD1	1105	broad.mit.edu	37	5	98195774	98195774	+	Splice_Site	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:98195774T>C	uc003knf.2	-	32	4576	c.4428_splice	c.e32-1	p.K1476_splice	CHD1_uc010jbn.2_Splice_Site_p.K202_splice	NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1						regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	CACAGGTTTCTAGAAGAATTT	0.313		NaN											0	0	0	0.001984	0	7	31									
SLC25A46	91137	broad.mit.edu	37	5	110091194	110091194	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:110091194A>G	uc003koz.2	+	6	660	c.593A>G	c.(592-594)CAA>CGA	p.Q198R	SLC25A46_uc011cvi.1_Missense_Mutation_p.Q107R	NM_138773	NP_620128	Q96AG3	S2546_HUMAN	solute carrier family 25, member 46	198					transport	integral to membrane|mitochondrial inner membrane					0		all_cancers(142;0.00203)|all_epithelial(76;4.52e-05)|Prostate(80;0.0115)|Colorectal(57;0.0676)|Ovarian(225;0.156)		OV - Ovarian serous cystadenocarcinoma(64;2.58e-09)|Epithelial(69;7.29e-08)|all cancers(49;9.35e-06)|COAD - Colon adenocarcinoma(37;0.211)		AGTCCTAAACAAATAGGAGAA	0.279		NaN											0	0	0	0.012319	0	16	39									
APC	324	broad.mit.edu	37	5	112154981	112154981	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:112154981G>T	uc010jby.2	+	10	1632	c.1252G>T	c.(1252-1254)GAA>TAA	p.E418*	APC_uc011cvt.1_Nonsense_Mutation_p.E400*|APC_uc003kpz.3_Nonsense_Mutation_p.E418*|APC_uc003kpy.3_Nonsense_Mutation_p.E418*|APC_uc010jbz.2_Nonsense_Mutation_p.E135*|APC_uc010jca.2_5'Flank	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	418	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity			large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CGCTTACTGTGAAACCTGTTG	0.468		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			1	0	7.53189e-24	0.007835	8.1564e-24	36	30									
CAMLG	819	broad.mit.edu	37	5	134074448	134074448	+	Silent	SNP	G	G	A	rs146867024		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:134074448G>A	uc003kzt.2	+	1	243	c.138G>A	c.(136-138)CGG>CGA	p.R46R	CAMLG_uc003kzu.2_Silent_p.R46R	NM_001745	NP_001736	P49069	CAMLG_HUMAN	calcium modulating ligand	46	Cytoplasmic (Potential).				defense response	endoplasmic reticulum|integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	GCATCAACCGGATCATGGGCT	0.637		NaN											0	0	0	0.000602	0	5	44									
CXCL14	9547	broad.mit.edu	37	5	134914132	134914132	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:134914132C>A	uc003lay.2	-	2	663	c.198G>T	c.(196-198)AAG>AAT	p.K66N		NM_004887	NP_004878	O95715	CXL14_HUMAN	small inducible cytokine B14 precursor	66					cell-cell signaling|chemotaxis|immune response|signal transduction	extracellular space|Golgi apparatus	chemokine activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACATAACCATCTTCTCCTCGC	0.572		NaN											1	0	8.58068e-18	0.007291	9.26886e-18	29	66									
APBB3	10307	broad.mit.edu	37	5	139938224	139938224	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:139938224G>C	uc003lgd.1	-	12	1781	c.1422C>G	c.(1420-1422)GTC>GTG	p.V474V	SRA1_uc003lfz.2_5'Flank|SRA1_uc010jfm.2_5'Flank|SRA1_uc003lga.2_5'Flank|APBB3_uc003lgb.1_Silent_p.V246V|APBB3_uc003lgc.1_Silent_p.V246V|APBB3_uc003lge.1_Silent_p.V467V|APBB3_uc003lgf.1_RNA|APBB3_uc010jfp.1_RNA|APBB3_uc011czi.1_Silent_p.V246V	NM_133172	NP_573418	O95704	APBB3_HUMAN	amyloid beta precursor protein-binding, family	469						actin cytoskeleton|cytoplasm				ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAAGAGAAGACACCCCGCT	0.597		NaN											0	0	0	0.006999	0	41	66									
PCDHA10	56139	broad.mit.edu	37	5	140237513	140237513	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:140237513C>T	uc003lhx.2	+	1	1880	c.1880C>T	c.(1879-1881)ACG>ATG	p.T627M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.T627M	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	627	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCTGTACACGGGCGAGATC	0.647		NaN											0	0	0	0.003163	0	15	3									
PCDHGB1	56104	broad.mit.edu	37	5	140730558	140730558	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:140730558A>G	uc003ljo.1	+	1	731	c.731A>G	c.(730-732)TAC>TGC	p.Y244C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.Y244C	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	244	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGAGGTATACAGGGTTAGC	0.567		NaN											0	0	0	0.004007	0	16	46									
PCDH1	5097	broad.mit.edu	37	5	141244801	141244801	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:141244801G>A	uc003llq.2	-	3	1212	c.1095C>T	c.(1093-1095)AAC>AAT	p.N365N	PCDH1_uc003llp.2_Silent_p.N365N|PCDH1_uc011dbf.1_Silent_p.N343N	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	365	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CACTCTTGGGGTTGGTGCCTC	0.577		NaN											0	0	0	0.014323	0	19	104									
RBM27	54439	broad.mit.edu	37	5	145634557	145634557	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:145634557C>T	uc003lnz.3	+	10	1662	c.1496C>T	c.(1495-1497)TCT>TTT	p.S499F	RBM27_uc003lny.2_Missense_Mutation_p.S444F	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	499					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATTACTAGTTCTGGTAGATCT	0.408		NaN											0	0	0	0.007413	0	16	31									
GPR151	134391	broad.mit.edu	37	5	145895361	145895361	+	Missense_Mutation	SNP	G	G	T	rs147138565	byFrequency	TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:145895361G>T	uc003lod.1	-	1	316	c.316C>A	c.(316-318)CTA>ATA	p.L106I		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	106	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACCAGCCTAGATCCCAAACA	0.507		NaN											1	0	1.5842e-08	0.001855	1.67351e-08	14	60									
PCYOX1L	78991	broad.mit.edu	37	5	148743624	148743624	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:148743624G>C	uc003lqk.2	+	3	383	c.321G>C	c.(319-321)GTG>GTC	p.V107V	PCYOX1L_uc003lql.2_Silent_p.V90V|PCYOX1L_uc010jgz.2_Silent_p.V90V|PCYOX1L_uc003lqm.2_5'UTR|PCYOX1L_uc003lqn.2_Silent_p.V17V	NM_024028	NP_076933	Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like precursor	107					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGAGGTGGTGGGCAGGAGCG	0.617		NaN											0	0	0	0.013537	0	11	60									
ZNF300	91975	broad.mit.edu	37	5	150275006	150275006	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:150275006G>A	uc003lsy.1	-	6	2062	c.1795C>T	c.(1795-1797)CAC>TAC	p.H599Y	IRGM_uc011dcl.1_Intron	NM_052860	NP_443092	Q96RE9	ZN300_HUMAN	zinc finger protein 300	599	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCACTGTGTGAATTCTCTGG	0.388		NaN											0	0	0	0.00308	0	7	46									
NMUR2	56923	broad.mit.edu	37	5	151784387	151784387	+	Silent	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:151784387G>T	uc003luv.2	-	1	454	c.288C>A	c.(286-288)CTC>CTA	p.L96L		NM_020167	NP_064552	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	96	Helical; Name=2; (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			ovary(3)|skin(2)|lung(1)|breast(1)|pancreas(1)	8		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GCATTCCAAGGAGCAGGACCA	0.577		NaN											1	0	1.90571e-15	0.004289	2.04828e-15	33	65									
LSM11	134353	broad.mit.edu	37	5	157171172	157171172	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:157171172G>A	uc003lxe.1	+	1	418	c.414G>A	c.(412-414)AGG>AGA	p.R138R		NM_173491	NP_775762	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	138					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCGGAGCAGGAAGGCGCCAC	0.751		NaN											0	0	0	0.004672	0	3	4									
ATP10B	23120	broad.mit.edu	37	5	160033923	160033923	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:160033923C>G	uc003lym.1	-	19	3856	c.3009G>C	c.(3007-3009)TTG>TTC	p.L1003F	ATP10B_uc010jit.1_Missense_Mutation_p.L320F	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1003	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATGGCATTCAATGTCTTCC	0.512		NaN											0	0	0	0.00245	0	12	88									
HMMR	3161	broad.mit.edu	37	5	162894721	162894721	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:162894721G>A	uc003lzf.2	+	4	419	c.237G>A	c.(235-237)AAG>AAA	p.K79K	HMMR_uc003lzh.2_Silent_p.K80K|HMMR_uc003lzg.2_Intron|HMMR_uc011dem.1_Intron	NM_012484	NP_036616	O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor isoform b	79						cell surface|cytoplasm	hyaluronic acid binding				0	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		AATCTCAAAAGAATGATAAAG	0.294		NaN											0	0	0	0.004672	0	3	19									
SLIT3	6586	broad.mit.edu	37	5	168175367	168175367	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:168175367C>T	uc003mab.2	-	20	2630	c.2210G>A	c.(2209-2211)CGA>CAA	p.R737Q	SLIT3_uc010jjg.2_Missense_Mutation_p.R737Q	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	737	LRRNT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTTGCTGCATCGCACCACTGT	0.642		NaN											0	0	0	0.004289	0	36	64									
TLX3	30012	broad.mit.edu	37	5	170736467	170736467	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:170736467C>T	uc003mbf.2	+	1	180	c.98C>T	c.(97-99)CCC>CTC	p.P33L	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	33						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GACAGCGCACCCGCCCCGCGG	0.751		NaN	T	BCL11B	T-ALL								0	0	0	0.004672	0	3	12									
RPL26L1	51121	broad.mit.edu	37	5	172386963	172386963	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:172386963C>T	uc003mcc.2	+	2	129	c.87C>T	c.(85-87)ATC>ATT	p.I29I	LOC100268168_uc011dfb.1_5'Flank|LOC100268168_uc011dfc.1_5'Flank	NM_016093	NP_057177	Q9UNX3	RL26L_HUMAN	ribosomal protein L26-like 1	29					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCAGGAAGATCATGTCATCCC	0.577		NaN											0	0	0	0.003271	0	31	87									
RGS14	10636	broad.mit.edu	37	5	176798587	176798587	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:176798587G>A	uc003mgf.2	+	14	1677	c.1495G>A	c.(1495-1497)GAA>AAA	p.E499K	RGS14_uc003mgh.2_Missense_Mutation_p.E347K|RGS14_uc003mgi.2_Missense_Mutation_p.E270K|RGS14_uc003mgj.2_RNA	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	499	GoLoco.				chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGTGACATCGAAGGTACATG	0.587		NaN											0	0	0	0.00623	0	40	58									
F12	2161	broad.mit.edu	37	5	176831015	176831015	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:176831015C>T	uc003mgo.3	-	10	1144	c.1095G>A	c.(1093-1095)AAG>AAA	p.K365K	F12_uc011dfy.1_5'UTR|F12_uc003mgn.3_5'UTR|F12_uc010jkl.2_RNA	NM_000505	NP_000496	P00748	FA12_HUMAN	coagulation factor XII precursor	365					Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGACAGACTCTTGCGGAGCC	0.701		NaN							Hereditary_Angioedema		OREG0017088	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	8	31									
MAML1	9794	broad.mit.edu	37	5	179195951	179195951	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:179195951A>G	uc003mkm.2	+	3	2095	c.1832A>G	c.(1831-1833)TAT>TGT	p.Y611C	MAML1_uc003mkn.1_Missense_Mutation_p.Y611C	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	611					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTCCCCCTATCTCAGCAGC	0.572		NaN											0	0	0	0.01441	0	55	83									
TRIM41	90933	broad.mit.edu	37	5	180660709	180660709	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr5:180660709C>T	uc003mne.1	+	5	1931	c.1237C>T	c.(1237-1239)CTG>TTG	p.L413L	TRIM41_uc003mnc.1_3'UTR|TRIM41_uc003mnd.1_Silent_p.L413L|TRIM41_uc003mnf.1_RNA|TRIM41_uc003mng.1_5'UTR	NM_033549	NP_291027	Q8WV44	TRI41_HUMAN	tripartite motif-containing 41 isoform 1	413	B30.2/SPRY.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding				0	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCATGACTTCCTGACAGATGC	0.602		NaN											0	0	0	0.004007	0	15	51									
PHACTR1	221692	broad.mit.edu	37	6	13206114	13206114	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:13206114A>G	uc010jpc.2	+	8	1064	c.732A>G	c.(730-732)AAA>AAG	p.K244K	PHACTR1_uc011dir.1_Silent_p.K313K|PHACTR1_uc003nag.1_Silent_p.K244K|PHACTR1_uc003nah.1_Silent_p.K244K	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	244						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CTCCAAAGAAAGTCATGATCT	0.592		NaN											0	0	0	0.010818	0	28	33									
PPP1R10	5514	broad.mit.edu	37	6	30569384	30569384	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:30569384C>T	uc003nqn.1	-	20	3317	c.2765G>A	c.(2764-2766)CGC>CAC	p.R922H	PPP1R10_uc010jsc.1_Missense_Mutation_p.R576H	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	922	C3H1-type.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						GTTCTCATAGCGGCAGTTGCC	0.552		NaN											0	0	0	0.00245	0	12	14									
VARS2	57176	broad.mit.edu	37	6	30884903	30884903	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:30884903G>A	uc003nsc.1	+	8	1407	c.775G>A	c.(775-777)GAA>AAA	p.E259K	VARS2_uc003nsd.2_Missense_Mutation_p.E259K|VARS2_uc011dmx.1_Missense_Mutation_p.E259K|VARS2_uc011dmy.1_Missense_Mutation_p.E119K|VARS2_uc011dmz.1_Missense_Mutation_p.E289K|VARS2_uc011dna.1_Missense_Mutation_p.E259K|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'Flank|VARS2_uc010jsg.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	259					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						GGCTGTGACTGAAGCTTTTGT	0.547		NaN											0	0	0	0.011902	0	43	37									
C6orf47	57827	broad.mit.edu	37	6	31627076	31627076	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:31627076G>C	uc003nvm.1	-	1	1474	c.649C>G	c.(649-651)CTC>GTC	p.L217V		NM_021184	NP_067007	O95873	CF047_HUMAN	G4 protein	217										ovary(1)	1						TGTAGCCAGAGGCCCAGCGGT	0.637		NaN											0	0	0	0.00499	0	16	18									
HLA-DQB1	3119	broad.mit.edu	37	6	32632653	32632653	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:32632653C>T	uc003obw.2	-	2	383	c.301G>A	c.(301-303)GAG>AAG	p.E101K	HLA-DQB1_uc010juc.1_Missense_Mutation_p.E56K|HLA-DQB1_uc003obv.2_Missense_Mutation_p.E101K|HLA-DQB1_uc011dqd.1_Missense_Mutation_p.E101K|HLA-DQB1_uc011dqe.1_Missense_Mutation_p.E101K	NM_002123	NP_002114	P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ	101	Extracellular (Potential).|Beta-1.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CGGGTCCCCTCCAGGACTTCC	0.672		NaN							Melanoma_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia|T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Sj_gren_syndrome				0	0	0	0.008291	0	3	3									
TAP1	6890	broad.mit.edu	37	6	32815407	32815407	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:32815407G>A	uc003ocg.2	-	9	2121	c.1966C>T	c.(1966-1968)CAA>TAA	p.Q656*	PSMB8_uc003ocf.2_5'Flank|TAP1_uc011dqi.1_Nonsense_Mutation_p.Q395*	NM_000593	NP_000584	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family	656	Cytoplasmic (Potential).|ABC transporter.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			skin(1)	1						ATATTTTCTTGAAGACTTCTT	0.468		NaN											0	0	0	0.006122	0	17	25									
HLA-DMB	3109	broad.mit.edu	37	6	32908579	32908579	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:32908579G>A	uc003ocl.1	-	1	239	c.6C>T	c.(4-6)ATC>ATT	p.I2I	HLA-DMB_uc003ocj.1_Silent_p.I2I|HLA-DMB_uc011dql.1_Silent_p.I2I	NM_002118	NP_002109	P28068	DMB_HUMAN	major histocompatibility complex, class II, DM	2					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex					0						GCAGGAATGTGATCATGCTCT	0.622		NaN											0	0	0	0.004672	0	3	6									
ZBTB22	9278	broad.mit.edu	37	6	33284074	33284074	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:33284074T>C	uc003oeb.2	-	2	772	c.620A>G	c.(619-621)AAC>AGC	p.N207S	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Missense_Mutation_p.N207S	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCTGAAGTAGTTGCTGCTGCT	0.627		NaN											0	0	0	0.006122	0	19	17									
KIFC1	3833	broad.mit.edu	37	6	33371898	33371898	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:33371898G>A	uc003oef.3	+	6	1198	c.748G>A	c.(748-750)GAG>AAG	p.E250K	KIFC1_uc011drf.1_Missense_Mutation_p.E242K	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	250	Potential.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CCAACTAGAGGAGAAGGAGGT	0.572		NaN											0	0	0	0.004007	0	14	16									
C6orf222	389384	broad.mit.edu	37	6	36287385	36287385	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:36287385G>A	uc003oly.2	-	11	1849	c.1671C>T	c.(1669-1671)ATC>ATT	p.I557I		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	557										skin(2)|ovary(1)|breast(1)	4						GGTGGCGCCTGATCTGGAAGT	0.582		NaN											0	0	0	0.012319	0	19	34									
ROS1	6098	broad.mit.edu	37	6	117631384	117631384	+	Silent	SNP	C	C	A	rs148504976		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:117631384C>A	uc003pxp.1	-	40	6493	c.6294G>T	c.(6292-6294)GTG>GTT	p.V2098V	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2098	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.V2098V(1)		lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CTCCAATCTTCACTATCCGTG	0.408		NaN	T	GOPC|ROS1	glioblastoma|NSCLC								1	0	1.51943e-15	0.01441	1.63514e-15	45	37									
ROS1	6098	broad.mit.edu	37	6	117683996	117683996	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:117683996T>C	uc003pxp.1	-	21	3350	c.3151A>G	c.(3151-3153)ATA>GTA	p.I1051V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1051	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CTTGGTAATATAAATATTCTG	0.348		NaN	T	GOPC|ROS1	glioblastoma|NSCLC								0	0	0	0.001855	0	14	11									
TRMT11	60487	broad.mit.edu	37	6	126320655	126320655	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:126320655A>G	uc003qam.2	+	7	696	c.575A>G	c.(574-576)CAC>CGC	p.H192R	TRMT11_uc003qan.2_RNA|TRMT11_uc010kev.2_Missense_Mutation_p.H192R	NM_001031712	NP_001026882	Q7Z4G4	TRM11_HUMAN	tRNA methyltransferase 11	192					tRNA processing		methyltransferase activity|nucleic acid binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0356)		AAAAAGAGACACTTTATTGGA	0.338		NaN											0	0	0	0.010818	0	32	16									
SAMD3	154075	broad.mit.edu	37	6	130465682	130465682	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:130465682G>T	uc003qbv.2	-	13	1872	c.1546C>A	c.(1546-1548)CAG>AAG	p.Q516K	SAMD3_uc003qbx.2_Missense_Mutation_p.Q516K|SAMD3_uc003qbw.2_Missense_Mutation_p.Q516K	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	516										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		AGTGGGTGCTGAAATCCTACT	0.368		NaN											1	0	3.07112e-06	0.010729	3.20885e-06	9	26									
EPB41L2	2037	broad.mit.edu	37	6	131216209	131216209	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:131216209G>C	uc003qch.2	-	9	1469	c.1287C>G	c.(1285-1287)CTC>CTG	p.L429L	EPB41L2_uc003qcg.1_Silent_p.L429L|EPB41L2_uc011eby.1_Silent_p.L429L|EPB41L2_uc003qci.2_Silent_p.L429L|EPB41L2_uc010kfk.2_Silent_p.L429L|EPB41L2_uc010kfl.1_Silent_p.L429L	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	429	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CTTTGTAAATGAGAAGTCCAT	0.423		NaN											0	0	0	0.01441	0	49	34									
UTRN	7402	broad.mit.edu	37	6	144898326	144898326	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:144898326G>A	uc003qkt.2	+	50	7473	c.7381G>A	c.(7381-7383)GAA>AAA	p.E2461K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2461	Spectrin 17.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GTGGATCCAAGAAGCAGAGAC	0.512		NaN											0	0	0	0.014323	0	22	20									
TIAM2	26230	broad.mit.edu	37	6	155561805	155561805	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:155561805A>G	uc003qqb.2	+	18	4583	c.3310A>G	c.(3310-3312)ATC>GTC	p.I1104V	TIAM2_uc003qqe.2_Missense_Mutation_p.I1104V|TIAM2_uc010kjj.2_Missense_Mutation_p.I637V|TIAM2_uc003qqf.2_Missense_Mutation_p.I480V|TIAM2_uc011efl.1_Missense_Mutation_p.I440V|TIAM2_uc003qqg.2_Missense_Mutation_p.I416V|TIAM2_uc003qqh.2_Missense_Mutation_p.I29V	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1104	DH.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCGCAAAGTCATCCAGGAGCT	0.567		NaN											0	0	0	0.008871	0	16	24									
SERAC1	84947	broad.mit.edu	37	6	158565401	158565401	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:158565401C>T	uc003qrc.2	-	7	681	c.539G>A	c.(538-540)GGT>GAT	p.G180D	SERAC1_uc003qrb.2_5'UTR	NM_032861	NP_116250	Q96JX3	SRAC1_HUMAN	serine active site containing 1	180					GPI anchor metabolic process|intracellular protein transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	binding|hydrolase activity, acting on ester bonds				0		Breast(66;0.00519)|Ovarian(120;0.123)|Prostate(117;0.178)		OV - Ovarian serous cystadenocarcinoma(65;1.37e-18)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)		TCGTGCCAAACCAATAAGAGT	0.343		NaN											0	0	0	0.007413	0	18	19									
WDR27	253769	broad.mit.edu	37	6	170047876	170047876	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:170047876C>G	uc003qwx.2	-	16	2170	c.1650G>C	c.(1648-1650)CAG>CAC	p.Q550H	WDR27_uc003qwv.1_RNA|WDR27_uc010kkw.1_Missense_Mutation_p.Q550H|WDR27_uc003qwy.2_Missense_Mutation_p.Q423H			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	520	WD 5.									pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		CACCTGAGTACTGGATGCAGC	0.562		NaN											0	0	0	0.009096	0	4	2									
DLL1	28514	broad.mit.edu	37	6	170597489	170597489	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr6:170597489C>T	uc003qxm.2	-	4	978	c.508G>A	c.(508-510)GAC>AAC	p.D170N	DLL1_uc011ehc.1_Missense_Mutation_p.D170N	NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	170	Extracellular (Potential).				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		TACTTGAGGTCCGTGCGGCCG	0.627		NaN											0	0	0	0.014323	0	21	21									
EIF3B	8662	broad.mit.edu	37	7	2400441	2400441	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:2400441G>A	uc003slx.2	+	2	679	c.596G>A	c.(595-597)CGA>CAA	p.R199Q	EIF3B_uc003sly.2_Missense_Mutation_p.R199Q|EIF3B_uc003slz.1_Missense_Mutation_p.R160Q|EIF3B_uc003sma.2_5'UTR	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	199	Sufficient for interaction with EIF3E.|RRM.|Sufficient for interaction with EIF3J.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GGACCCGACCGACTTGAGAAA	0.443		NaN											0	0	0	0.012319	0	22	45									
SLC29A4	222962	broad.mit.edu	37	7	5338755	5338755	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:5338755G>A	uc003sod.2	+	8	1180	c.1019G>A	c.(1018-1020)AGA>AAA	p.R340K	SLC29A4_uc011jwg.1_RNA|SLC29A4_uc003soc.2_Missense_Mutation_p.R340K|SLC29A4_uc003soe.2_Missense_Mutation_p.R326K|SLC29A4_uc010ksw.2_RNA	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	340	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		CCCACCTTCAGAGGTGAGTGC	0.721		NaN											0	0	0	0.00308	0	7	20									
RNF216	54476	broad.mit.edu	37	7	5760771	5760771	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:5760771G>A	uc003soy.1	-	9	1556	c.1366C>T	c.(1366-1368)CTT>TTT	p.L456F	RNF216_uc010ksz.1_Missense_Mutation_p.L78F|RNF216_uc010kta.1_Missense_Mutation_p.L78F|RNF216_uc011jwj.1_Missense_Mutation_p.L78F|RNF216_uc003sox.1_Missense_Mutation_p.L513F	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	456					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TTATTTTCAAGAAAGAACATC	0.428		NaN											0	0	0	0.00278	0	23	49									
DNAH11	8701	broad.mit.edu	37	7	21639522	21639522	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:21639522T>A	uc003svc.2	+	15	2816	c.2785T>A	c.(2785-2787)TTC>ATC	p.F929I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	929	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CGACTTAGACTTCTTTCTGAA	0.398		NaN							Kartagener_syndrome				0	0	0	0.000602	0	5	32									
TRIL	9865	broad.mit.edu	37	7	28996568	28996568	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:28996568G>A	uc003szt.2	-	3	1462	c.1095C>T	c.(1093-1095)TGC>TGT	p.C365C	uc003szu.1_5'Flank	NM_014817	NP_055632	Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine rich repeats	365	Extracellular (Potential).|LRRCT.				inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding				0						CTCGCAGCCGGCAGTCGCAGG	0.687		NaN											0	0	0	0.009096	0	4	10									
NEUROD6	63974	broad.mit.edu	37	7	31378784	31378784	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:31378784C>A	uc003tch.2	-	2	452	c.99G>T	c.(97-99)AAG>AAT	p.K33N		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	33					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						AGCTTTCTGGCTTCTTAATTT	0.343		NaN											1	0	2.24893e-16	0.009718	2.42626e-16	44	110									
TMED4	222068	broad.mit.edu	37	7	44620691	44620691	+	Splice_Site	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:44620691C>T	uc003tli.2	-	4	556	c.534_splice	c.e4+1	p.R178_splice	TMED4_uc003tlj.2_Missense_Mutation_p.A120T|TMED4_uc003tlk.2_Missense_Mutation_p.A179T|uc003tll.2_5'Flank	NM_182547	NP_872353	Q7Z7H5	TMED4_HUMAN	transmembrane emp24 protein transport domain						positive regulation of I-kappaB kinase/NF-kappaB cascade|transport	endoplasmic reticulum membrane|integral to membrane	signal transducer activity				0						TATGCACTTGCCCTTTGGTAA	0.483		NaN											0	0	0	0.007413	0	17	43									
OGDH	4967	broad.mit.edu	37	7	44739760	44739760	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:44739760C>T	uc003tln.2	+	19	2560	c.2451C>T	c.(2449-2451)TTC>TTT	p.F817F	OGDH_uc011kbx.1_Silent_p.F813F|OGDH_uc011kby.1_Silent_p.F667F|OGDH_uc003tlp.2_Silent_p.F828F|OGDH_uc011kbz.1_Silent_p.F612F	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	817					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	AAGCCAACTTCGACATCAATC	0.532		NaN											0	0	0	0.007835	0	39	69									
TYW1B	441250	broad.mit.edu	37	7	72277753	72277753	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:72277753C>T	uc011kej.1	-	5	788	c.629G>A	c.(628-630)TGC>TAC	p.C210Y	TYW1B_uc011keh.1_Intron|TYW1B_uc011kek.1_RNA	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	210					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GCCTTTCTTGCAGTGGCCGCC	0.517		NaN											0	0	0	0.00308	0	8	20									
WBSCR27	155368	broad.mit.edu	37	7	73255423	73255423	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:73255423C>T	uc003tzj.2	-	3	269	c.229G>A	c.(229-231)GGC>AGC	p.G77S	RFC2_uc011kfa.1_Intron|WBSCR27_uc011kfd.1_Missense_Mutation_p.G77S	NM_152559	NP_689772	Q8N6F8	WBS27_HUMAN	Williams-Beuren syndrome chromosome region 27	77										central_nervous_system(1)	1		Lung NSC(55;0.159)				AGGCCTGTGCCACAGGCCACG	0.662		NaN											0	0	0	0.000602	0	5	13									
PTPN12	5782	broad.mit.edu	37	7	77230076	77230076	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:77230076G>A	uc003ugh.2	+	8	739	c.648G>A	c.(646-648)ATG>ATA	p.M216I	PTPN12_uc011kgp.1_Missense_Mutation_p.M97I|PTPN12_uc011kgq.1_Missense_Mutation_p.M86I	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	216	Tyrosine-protein phosphatase.					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						TAAGCTTAATGAGGAAATATC	0.328		NaN											0	0	0	0.004672	0	3	25									
CD36	948	broad.mit.edu	37	7	80301250	80301250	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:80301250A>G	uc003uhc.2	+	14	1703	c.1019A>G	c.(1018-1020)TAC>TGC	p.Y340C	CD36_uc003uhd.3_Missense_Mutation_p.Y340C|CD36_uc011kgv.1_Missense_Mutation_p.Y264C|CD36_uc003uhe.3_Missense_Mutation_p.Y340C|CD36_uc003uhf.3_Missense_Mutation_p.Y340C|CD36_uc003uhg.3_Missense_Mutation_p.Y340C|CD36_uc003uhh.3_Missense_Mutation_p.Y340C	NM_001127444	NP_001120916	P16671	CD36_HUMAN	CD36 antigen	340	Extracellular (Potential).				cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			ovary(1)	1						AGACCTGTGTACATTTCACTT	0.328		NaN											0	0	0	0.008291	0	10	41									
SEMA3A	10371	broad.mit.edu	37	7	83823856	83823856	+	Missense_Mutation	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:83823856A>C	uc003uhz.2	-	1	362	c.47T>G	c.(46-48)CTT>CGT	p.L16R		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	16					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TCTTGCTGTAAGTAATACTCC	0.408		NaN											0	0	0	0.007291	0	25	77									
SEMA3D	223117	broad.mit.edu	37	7	84649547	84649547	+	Splice_Site	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:84649547A>G	uc003uic.2	-	12	1543	c.1503_splice	c.e12+1	p.K501_splice	SEMA3D_uc010led.2_Splice_Site_p.K501_splice|SEMA3D_uc003uib.2_Splice_Site_p.K140_splice	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor						cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						ACTGAGTCTTACCTTGAATAT	0.413		NaN											0	0	0	0.001168	0	6	28									
CYP3A4	1576	broad.mit.edu	37	7	99358539	99358539	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:99358539C>T	uc003urv.1	-	12	1423	c.1319G>A	c.(1318-1320)AGA>AAA	p.R440K	CYP3A4_uc003urw.1_Missense_Mutation_p.R439K|CYP3A4_uc011kiz.1_Missense_Mutation_p.R399K|CYP3A4_uc011kja.1_Missense_Mutation_p.R391K|CYP3A4_uc011kjb.1_Missense_Mutation_p.R290K	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	440					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	AATGCAGTTTCTGGGTCCACT	0.393		NaN											0	0	0	0.01441	0	44	68									
CYP3A4	1576	broad.mit.edu	37	7	99359668	99359668	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:99359668C>G	uc003urv.1	-	11	1353	c.1249G>C	c.(1249-1251)GAA>CAA	p.E417Q	CYP3A4_uc003urw.1_Missense_Mutation_p.E416Q|CYP3A4_uc011kiz.1_Missense_Mutation_p.E376Q|CYP3A4_uc011kja.1_Missense_Mutation_p.E368Q|CYP3A4_uc011kjb.1_Missense_Mutation_p.E267Q	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	417					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTGTACCTTTCAGGGAGGAAC	0.507		NaN											0	0	0	0.00632	0	25	91									
OR2AE1	81392	broad.mit.edu	37	7	99473945	99473945	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:99473945C>G	uc003usc.1	-	1	712	c.712G>C	c.(712-714)GCC>CCC	p.A238P		NM_001005276	NP_001005276	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CCACAAGTGGCAAAGGCATTT	0.498		NaN											0	0	0	0.004482	0	8	35									
MUC17	140453	broad.mit.edu	37	7	100684143	100684143	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:100684143C>T	uc003uxp.1	+	3	9499	c.9446C>T	c.(9445-9447)TCT>TTT	p.S3149F	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3149	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|51.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTACAACTTCTGAAGGTACC	0.488		NaN											0	0	0	0.01441	0	68	311									
LAMB1	3912	broad.mit.edu	37	7	107594021	107594021	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:107594021G>A	uc003vew.2	-	22	3368	c.3033C>T	c.(3031-3033)TTC>TTT	p.F1011F	LAMB1_uc003vev.2_Silent_p.F1035F	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1011	Laminin EGF-like 10.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAAACCGGCAGAACTGACAGT	0.493		NaN											0	0	0	0.01441	0	47	36									
DOCK4	9732	broad.mit.edu	37	7	111541741	111541741	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:111541741T>C	uc003vfx.2	-	14	1578	c.1309A>G	c.(1309-1311)ACC>GCC	p.T437A	DOCK4_uc003vfy.2_Missense_Mutation_p.T437A|DOCK4_uc003vga.1_Missense_Mutation_p.T42A	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	437	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ACCTTCAGGGTTTGGCCACTA	0.358		NaN											0	0	0	0.008291	0	11	39									
AASS	10157	broad.mit.edu	37	7	121738842	121738842	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:121738842T>C	uc003vka.2	-	13	1581	c.1485A>G	c.(1483-1485)GTA>GTG	p.V495V	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.V495V|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	495	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	AATATTCTAATACAGGCTCAG	0.328		NaN											0	0	0	0.013537	0	12	61									
PAX4	5078	broad.mit.edu	37	7	127251629	127251629	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:127251629C>T	uc010lld.1	-	8	1055	c.849G>A	c.(847-849)CTG>CTA	p.L283L	PAX4_uc003vmf.2_Silent_p.L281L|PAX4_uc003vmg.1_Silent_p.L283L	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	291	Transcription repression.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGGTGTCACTCAGACACCTTT	0.607		NaN											0	0	0	0.008871	0	20	105									
PLXNA4	91584	broad.mit.edu	37	7	131853207	131853207	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:131853207C>T	uc003vra.3	-	22	4371	c.4142G>A	c.(4141-4143)CGC>CAC	p.R1381H		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1381	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GCCACGGTCGCGCATGGAGAA	0.582		NaN											0	0	0	0.004482	0	6	43									
EXOC4	60412	broad.mit.edu	37	7	133622721	133622721	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:133622721G>T	uc003vrk.2	+	14	2140	c.2105G>T	c.(2104-2106)CGT>CTT	p.R702L	EXOC4_uc011kpo.1_Missense_Mutation_p.R601L|EXOC4_uc003vrl.2_Missense_Mutation_p.R312L|EXOC4_uc011kpp.1_Missense_Mutation_p.R234L|EXOC4_uc011kpq.1_5'UTR	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	702					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GACATCCTTCGTGACGTCAGT	0.458		NaN											1	0	0.000673444	0.008291	0.000694388	11	78									
WDR91	29062	broad.mit.edu	37	7	134894412	134894412	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:134894412G>A	uc003vsp.2	-	2	281	c.219C>T	c.(217-219)TTC>TTT	p.F73F	WDR91_uc010lmq.2_5'Flank|WDR91_uc010lmr.2_5'Flank	NM_014149	NP_054868	A4D1P6	WDR91_HUMAN	WD repeat domain 91	73										breast(2)|ovary(1)|skin(1)	4						CCAAGCGGCTGAAGAGCCGAC	0.493		NaN											0	0	0	0.01441	0	46	83									
MLL3	58508	broad.mit.edu	37	7	151945668	151945668	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:151945668T>C	uc003wla.2	-	14	2070	c.1851A>G	c.(1849-1851)AAA>AAG	p.K617K		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	617					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TAGAAATCTGTTTTTCCAATT	0.308		NaN	N		medulloblastoma								0	0	0	0.009096	0	4	29									
ANGPT2	285	broad.mit.edu	37	8	6378704	6378704	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:6378704G>C	uc003wqj.3	-	4	1123	c.794C>G	c.(793-795)TCA>TGA	p.S265*	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Nonsense_Mutation_p.S265*|ANGPT2_uc010lri.2_Nonsense_Mutation_p.S213*|ANGPT2_uc003wql.3_Nonsense_Mutation_p.S265*	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	265					angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		CTTACAGTTTGATGTGGACAT	0.353		NaN											0	0	0	0.001984	0	6	26									
MTUS1	57509	broad.mit.edu	37	8	17612302	17612302	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:17612302C>T	uc003wxv.2	-	2	1489	c.1015G>A	c.(1015-1017)GAG>AAG	p.E339K	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Missense_Mutation_p.E339K|MTUS1_uc010lsz.2_Missense_Mutation_p.E339K	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	339						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GACACTGTCTCTCTCAGATTT	0.423		NaN											0	0	0	0.004656	0	28	42									
TNFRSF10C	8794	broad.mit.edu	37	8	22972236	22972236	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:22972236C>T	uc003xcy.2	+	3	434	c.233C>T	c.(232-234)GCT>GTT	p.A78V	TNFRSF10C_uc011kzr.1_RNA	NM_003841	NP_003832	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily,	78	TNFR-Cys 2.				apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		TACACCAACGCTTCCAACAAT	0.483		NaN											0	0	0	0.003755	0	29	40									
FZD3	7976	broad.mit.edu	37	8	28413267	28413267	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:28413267G>C	uc003xgx.2	+	7	2044	c.1566G>C	c.(1564-1566)GAG>GAC	p.E522D	FZD3_uc010lvb.2_Missense_Mutation_p.E522D	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	522	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		TAGTGAATGAGAGCCGACAGG	0.393		NaN											0	0	0	0.001855	0	12	45									
HMBOX1	79618	broad.mit.edu	37	8	28827975	28827975	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:28827975T>C	uc003xhd.3	+	3	781	c.439T>C	c.(439-441)TAC>CAC	p.Y147H	HMBOX1_uc010lvd.2_Missense_Mutation_p.Y147H|HMBOX1_uc003xhc.3_Missense_Mutation_p.Y147H|HMBOX1_uc010lve.2_RNA|HMBOX1_uc003xhe.2_Missense_Mutation_p.Y147H|HMBOX1_uc011lay.1_Missense_Mutation_p.Y147H|HMBOX1_uc003xhf.2_Missense_Mutation_p.Y135H|HMBOX1_uc003xhg.2_Missense_Mutation_p.Y135H	NM_001135726	NP_001129198	Q6NT76	HMBX1_HUMAN	homeobox containing 1	147					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		TCAGAGGTCATACAGTTTTGA	0.403		NaN											0	0	0	0.001168	0	5	46									
NRG1	3084	broad.mit.edu	37	8	32463142	32463142	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:32463142T>C	uc003xiv.2	+	3	858	c.341T>C	c.(340-342)GTG>GCG	p.V114A	NRG1_uc003xip.2_Missense_Mutation_p.V329A|NRG1_uc003xir.2_Missense_Mutation_p.V114A|NRG1_uc010lvl.2_Missense_Mutation_p.V114A|NRG1_uc010lvm.2_Missense_Mutation_p.V114A|NRG1_uc010lvn.2_Missense_Mutation_p.V114A|NRG1_uc003xis.2_Missense_Mutation_p.V114A|NRG1_uc011lbf.1_Missense_Mutation_p.V114A|NRG1_uc010lvo.2_Missense_Mutation_p.V114A|NRG1_uc003xiu.2_Missense_Mutation_p.V114A|NRG1_uc003xiw.2_Missense_Mutation_p.V114A|NRG1_uc003xit.2_Missense_Mutation_p.V114A|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Missense_Mutation_p.V80A|NRG1_uc010lvq.2_Missense_Mutation_p.V80A|NRG1_uc003xix.2_Missense_Mutation_p.V4A	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	114	Extracellular (Potential).|Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		ATGTGCAAAGTGATCAGCAAA	0.408		NaN											0	0	0	0.00278	0	21	35									
ADAM9	8754	broad.mit.edu	37	8	38928862	38928862	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:38928862A>G	uc003xmr.2	+	15	1715	c.1637A>G	c.(1636-1638)AAA>AGA	p.K546R	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA|ADAM9_uc003xms.2_RNA	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	546	Cys-rich.|Extracellular (Potential).				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			GTGAATTCTAAAGGTGACAGA	0.358		NaN											0	0	0	0.004007	0	14	17									
GOLGA7	51125	broad.mit.edu	37	8	41355114	41355114	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:41355114C>T	uc003xnu.2	+	3	276	c.198C>T	c.(196-198)CTC>CTT	p.L66L	GOLGA7_uc003xnv.2_RNA|GOLGA7_uc003xnw.2_Silent_p.L66L	NM_016099	NP_057183	Q7Z5G4	GOGA7_HUMAN	golgi autoantigen, golgin subfamily a, 7	66						Golgi membrane				breast(1)	1	Ovarian(28;0.014)|Colorectal(14;0.0234)|Lung SC(25;0.211)	all_lung(54;0.000771)|Lung NSC(58;0.0031)|Hepatocellular(245;0.014)|Esophageal squamous(32;0.0559)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00596)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AGTCATATCTCGAAGGTTGTT	0.383		NaN											0	0	0	0.014323	0	21	112									
POTEA	340441	broad.mit.edu	37	8	43152200	43152200	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:43152200G>A	uc003xpz.1	+	2	380	c.337G>A	c.(337-339)GAA>AAA	p.E113K	POTEA_uc003xqa.1_Missense_Mutation_p.E113K	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	113	ANK 1.									ovary(1)	1						TGGCAATTCAGAAGTAGTAAG	0.408		NaN											0	0	0	0.001855	0	14	74									
NPBWR1	2831	broad.mit.edu	37	8	53853103	53853103	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:53853103C>T	uc011ldu.1	+	1	636	c.636C>T	c.(634-636)TTC>TTT	p.F212F		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	212	Helical; Name=5; (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				TGCTGGGCTTCGCCATCCCCG	0.682		NaN											0	0	0	0.001984	0	7	10									
SDR16C5	195814	broad.mit.edu	37	8	57228775	57228775	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:57228775G>A	uc003xsy.1	-	2	770	c.132C>T	c.(130-132)CTC>CTT	p.L44L	SDR16C5_uc010lyk.1_Silent_p.L44L|SDR16C5_uc010lyl.1_Silent_p.L44L	NM_138969	NP_620419	Q8N3Y7	RDHE2_HUMAN	epidermal retinal dehydrogenase 2	44	NAD or NADP (By similarity).				detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CACCTGTGATGAGGACTATTT	0.468		NaN											0	0	0	0.001984	0	7	41									
CHD7	55636	broad.mit.edu	37	8	61655515	61655515	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:61655515T>C	uc003xue.2	+	2	2001	c.1524T>C	c.(1522-1524)TTT>TTC	p.F508F		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	508	Pro-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGCCATCTTTTCAGCAGTTGC	0.572		NaN											0	0	0	0.009096	0	3	17									
CHD7	55636	broad.mit.edu	37	8	61693742	61693742	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:61693742A>G	uc003xue.2	+	3	2326	c.1849A>G	c.(1849-1851)AAA>GAA	p.K617E		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	617	Lys-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			AGGTTTTGGTAAAGATGACTT	0.393		NaN											0	0	0	0.006214	0	9	7									
ARMC1	55156	broad.mit.edu	37	8	66517678	66517678	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:66517678G>A	uc003xvl.2	-	5	796	c.561C>T	c.(559-561)ATC>ATT	p.I187I	ARMC1_uc011leo.1_Silent_p.I85I	NM_018120	NP_060590	Q9NVT9	ARMC1_HUMAN	armadillo repeat-containing protein	187					metal ion transport		metal ion binding			skin(1)	1			Epithelial(68;0.103)|OV - Ovarian serous cystadenocarcinoma(28;0.235)			AATCTGAACGGATTCGCACCA	0.333		NaN											0	0	0	0.00632	0	23	33									
PREX2	80243	broad.mit.edu	37	8	69104737	69104737	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:69104737C>T	uc003xxv.1	+	37	4608	c.4581C>T	c.(4579-4581)ATC>ATT	p.I1527I		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1527					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GCCACATCATCATGTGCAGCA	0.522		NaN											0	0	0	0.008361	0	20	15									
TRPA1	8989	broad.mit.edu	37	8	72977734	72977734	+	Silent	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:72977734A>T	uc003xza.2	-	4	679	c.504T>A	c.(502-504)GCT>GCA	p.A168A		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	168	Cytoplasmic (Potential).|ANK 4.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CAATGATCACAGCTGTGTTTC	0.333		NaN											0	0	0	0.000602	0	5	32									
RDH10	157506	broad.mit.edu	37	8	74233221	74233221	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:74233221G>A	uc003xzi.2	+	4	939	c.679G>A	c.(679-681)GAA>AAA	p.E227K	RDH10_uc003xzj.2_Missense_Mutation_p.E62K|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	227					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			CCTGAGCCATGAACTAAAGGC	0.443		NaN											0	0	0	0.013726	0	31	49									
SLC7A13	157724	broad.mit.edu	37	8	87241991	87241991	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:87241991G>A	uc003ydq.1	-	1	614	c.516C>T	c.(514-516)AGC>AGT	p.S172S	SLC7A13_uc003ydr.1_Silent_p.S172S	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	172	Helical; Name=5; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						GGGAAATGAAGCTAAGTATGG	0.423		NaN											0	0	0	0.013726	0	30	35									
WWP1	11059	broad.mit.edu	37	8	87442959	87442959	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:87442959G>T	uc003ydt.2	+	12	1646	c.1366G>T	c.(1366-1368)GGA>TGA	p.G456*	WWP1_uc010mai.2_Nonsense_Mutation_p.G232*	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	456	WW 3.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						TGACCCTTATGGACCTTTGCC	0.294		NaN											1	0	4.3838e-07	0.001855	4.59712e-07	11	50									
RBM12B	389677	broad.mit.edu	37	8	94747139	94747139	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:94747139C>G	uc003yfz.2	-	3	1693	c.1500G>C	c.(1498-1500)CAG>CAC	p.Q500H		NM_203390	NP_976324	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	500							nucleotide binding|RNA binding				0	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GCTCACGTGACTGTGAGCGAG	0.408		NaN											0	0	0	0.012319	0	23	88									
RGS22	26166	broad.mit.edu	37	8	101083755	101083755	+	Silent	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:101083755A>G	uc003yjb.1	-	6	631	c.436T>C	c.(436-438)TTG>CTG	p.L146L	RGS22_uc003yja.1_Intron|RGS22_uc003yjc.1_Silent_p.L146L|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	146					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGTGAGACCAATTTGGCTAAC	0.368		NaN											0	0	0	0.014323	0	19	24									
CSMD3	114788	broad.mit.edu	37	8	113308174	113308174	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:113308174T>C	uc003ynu.2	-	54	8661	c.8502A>G	c.(8500-8502)GGA>GGG	p.G2834G	CSMD3_uc003yns.2_Silent_p.G2036G|CSMD3_uc003ynt.2_Silent_p.G2794G|CSMD3_uc011lhx.1_Silent_p.G2665G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2834	Extracellular (Potential).|Sushi 18.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGTCTCTATATCCATAATTTT	0.363		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.010729	0	9	45									
TRPS1	7227	broad.mit.edu	37	8	116616147	116616147	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:116616147T>A	uc003ynz.2	-	3	2469	c.2010A>T	c.(2008-2010)AAA>AAT	p.K670N	TRPS1_uc011lhy.1_Missense_Mutation_p.K674N|TRPS1_uc003yny.2_Missense_Mutation_p.K683N|TRPS1_uc010mcy.2_Missense_Mutation_p.K670N	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	670	Mediates interaction with GLI3.|C2H2-type 4.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TAAAATCACATTTGGTACATG	0.443		NaN							Langer-Giedion_syndrome				0	0	0	0.008361	0	27	27									
FER1L6	654463	broad.mit.edu	37	8	124975540	124975540	+	Silent	SNP	A	A	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:124975540A>C	uc003yqw.2	+	3	305	c.99A>C	c.(97-99)GCA>GCC	p.A33A		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	33	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACACTGAAGCACTGCAGGAGG	0.493		NaN											0	0	0	0.008871	0	19	99									
TRMT12	55039	broad.mit.edu	37	8	125463982	125463982	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:125463982G>T	uc003yra.3	+	1	935	c.814G>T	c.(814-816)GTT>TTT	p.V272F		NM_017956	NP_060426	Q53H54	TYW2_HUMAN	homolog of yeast tRNA methyltransferase 12	272					tRNA processing		methyltransferase activity			upper_aerodigestive_tract(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CCATGCTGTAGTTGCTCTGAG	0.438		NaN											1	0	8.28177e-16	0.007413	8.92361e-16	19	130									
FAM84B	157638	broad.mit.edu	37	8	127569332	127569332	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:127569332C>T	uc003yrz.1	-	2	587	c.303G>A	c.(301-303)TCG>TCA	p.S101S		NM_174911	NP_777571	Q96KN1	FA84B_HUMAN	family with sequence similarity 84, member B	101						cytoplasm|plasma membrane	protein binding				0	Ovarian(5;9.43e-05)|Esophageal squamous(12;0.0012)|Hepatocellular(40;0.128)|Myeloproliferative disorder(2;0.135)		STAD - Stomach adenocarcinoma(47;0.000556)|Colorectal(2;0.0102)|Lung(2;0.0136)|READ - Rectum adenocarcinoma(2;0.0723)			TCAGCGCCGCCGAGCCCGGCG	0.657		NaN											0	0	0	0.000602	0	5	35									
PHF20L1	51105	broad.mit.edu	37	8	133816268	133816268	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:133816268G>A	uc003ytt.2	+	7	1037	c.712G>A	c.(712-714)GAA>AAA	p.E238K	PHF20L1_uc003ytr.2_Missense_Mutation_p.E212K|PHF20L1_uc010mdv.2_Missense_Mutation_p.E212K|PHF20L1_uc003yts.2_Missense_Mutation_p.E238K|PHF20L1_uc011lja.1_Missense_Mutation_p.E212K|PHF20L1_uc003ytu.1_RNA|PHF20L1_uc003ytv.2_Missense_Mutation_p.E77K	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	238							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TACATCTAGTGAAACATTTGG	0.368		NaN											0	0	0	0.009096	0	4	23									
DENND3	22898	broad.mit.edu	37	8	142175310	142175310	+	Missense_Mutation	SNP	C	C	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:142175310C>G	uc003yvy.2	+	11	1513	c.1235C>G	c.(1234-1236)TCT>TGT	p.S412C	DENND3_uc010mep.2_Missense_Mutation_p.S373C|DENND3_uc003yvz.1_Missense_Mutation_p.S96C	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	412	dDENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			ATGTTCCATTCTTTTCTTAAA	0.557		NaN											0	0	0	0.01441	0	51	71									
GSDMD	79792	broad.mit.edu	37	8	144641548	144641548	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:144641548G>A	uc010mfe.2	+	5	746	c.43G>A	c.(43-45)GAG>AAG	p.E15K	uc003yye.2_5'Flank|GSDMD_uc003yyf.2_Missense_Mutation_p.E63K|GSDMD_uc003yyi.2_Missense_Mutation_p.E15K|GSDMD_uc003yyg.2_Missense_Mutation_p.E15K|GSDMD_uc003yyh.2_Missense_Mutation_p.E15K	NM_024736	NP_079012	P57764	GSDMD_HUMAN	gasdermin D	15											0						AGTGGTCCAGGAGCTGGACCA	0.632		NaN											0	0	0	0.012319	0	22	36									
FBXL6	26233	broad.mit.edu	37	8	145580113	145580113	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:145580113G>A	uc003zcb.2	-	7	1097	c.1072C>T	c.(1072-1074)CTA>TTA	p.L358L	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Silent_p.L85L|FBXL6_uc003zca.2_Silent_p.L352L|FBXL6_uc010mfx.2_Silent_p.L119L|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	358	LRR 6.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			AGCTCCTCTAGGCTAGGGAAG	0.642		NaN											0	0	0	0.00245	0	14	66									
GPR172A	79581	broad.mit.edu	37	8	145583820	145583820	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:145583820C>T	uc003zcc.1	+	3	825	c.668C>T	c.(667-669)TCT>TTT	p.S223F	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.S223F|GPR172A_uc003zce.1_Missense_Mutation_p.S223F|GPR172A_uc010mfy.1_Missense_Mutation_p.S223F|GPR172A_uc003zcf.1_Missense_Mutation_p.S223F|GPR172A_uc011llc.1_Missense_Mutation_p.S135F	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	223						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CCACCACCATCTGTACCCACA	0.612		NaN											0	0	0	0.00874	0	40	39									
NFKBIL2	4796	broad.mit.edu	37	8	145659460	145659460	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:145659460G>A	uc011llg.1	-	21	3303	c.3288C>T	c.(3286-3288)ACC>ACT	p.T1096T	uc011llh.1_5'Flank	NM_013432	NP_038460	Q96HA7	TONSL_HUMAN	NF-kappa-B inhibitor-like protein 2	1096					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGCTGGGCATGGTGCCCAGGG	0.687		NaN											0	0	0	0.013726	0	30	21									
KIFC2	90990	broad.mit.edu	37	8	145698738	145698738	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr8:145698738C>T	uc003zcz.2	+	17	2487	c.2422C>T	c.(2422-2424)CGG>TGG	p.R808W	KIFC2_uc003zda.2_Missense_Mutation_p.R196W	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	808	Pro-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			GGCTCGGGCTCGGCTCTCGCG	0.701		NaN											0	0	0	0.000602	0	5	12									
DMRT2	10655	broad.mit.edu	37	9	1057223	1057223	+	Missense_Mutation	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:1057223G>C	uc003zha.2	+	4	1836	c.1636G>C	c.(1636-1638)GAG>CAG	p.E546Q	DMRT2_uc003zgx.3_Missense_Mutation_p.E313Q|DMRT2_uc010mgz.2_Missense_Mutation_p.E313Q|DMRT2_uc003zgy.3_Missense_Mutation_p.E390Q|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Missense_Mutation_p.E546Q	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	546					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		ATTTTCTGTTGAGTCTATTCT	0.393		NaN											0	0	0	0.00333	0	22	19									
GLIS3	169792	broad.mit.edu	37	9	3828335	3828335	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:3828335G>A	uc003zhw.1	-	10	2459	c.2265C>T	c.(2263-2265)TTC>TTT	p.F755F	GLIS3_uc003zhx.1_Silent_p.F910F|GLIS3_uc010mhf.1_Silent_p.F304F|GLIS3_uc003zhv.1_RNA	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b	755					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		TGATCTGCAAGAAGGTAGCAT	0.542		NaN											0	0	0	0.006214	0	10	10									
RLN2	6019	broad.mit.edu	37	9	5304391	5304391	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:5304391G>A	uc003zja.1	-	1	190	c.190C>T	c.(190-192)CAG>TAG	p.Q64*	RLN2_uc003ziz.1_Nonsense_Mutation_p.Q64*	NM_134441	NP_604390	P04090	REL2_HUMAN	relaxin 2 isoform 1 preproprotein	64					female pregnancy	extracellular region	hormone activity				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.0987)		CTAGGTGTCTGAGGAGCATCT	0.597		NaN											0	0	0	0.001168	0	6	7									
PSIP1	11168	broad.mit.edu	37	9	15469043	15469043	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:15469043C>A	uc003zlv.3	-	13	1448	c.1118G>T	c.(1117-1119)TGC>TTC	p.C373F	PSIP1_uc003zlw.3_Missense_Mutation_p.C373F	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	373	Potential.				initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		GGCCTCAATGCATCTGTTCAC	0.343		NaN											1	0	1.33834e-09	0.007413	1.419e-09	18	11									
ARID3C	138715	broad.mit.edu	37	9	34623620	34623620	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:34623620C>T	uc011lon.1	-	4	667	c.667G>A	c.(667-669)GAG>AAG	p.E223K		NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CGACGGCCCTCGCGCCGATTG	0.701		NaN											0	0	0	0.006214	0	10	8									
C9orf79	286234	broad.mit.edu	37	9	90501167	90501167	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:90501167C>T	uc004app.3	+	4	1800	c.1765C>T	c.(1765-1767)CAG>TAG	p.Q589*	C9orf79_uc004apo.1_Nonsense_Mutation_p.Q401*	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	589						integral to membrane				ovary(3)	3						CAAAAAGTCTCAGGCTGTTCT	0.587		NaN											0	0	0	0.01441	0	54	62									
C9orf3	84909	broad.mit.edu	37	9	97844946	97844946	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:97844946G>A	uc004ava.2	+	15	2544	c.2409G>A	c.(2407-2409)AAG>AAA	p.K803K	C9orf3_uc004auy.2_Silent_p.K704K|C9orf3_uc004avc.2_Intron|C9orf3_uc011luj.1_Silent_p.K165K|C9orf3_uc011luk.1_Silent_p.K144K|C9orf3_uc004avd.2_Silent_p.K165K|MIR23B_hsa-mir-23b|MI0000439_5'Flank|uc004avg.3_5'Flank|MIR27B_hsa-mir-27b|MI0000440_5'Flank	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	803					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		AGCGGACCAAGGAGCAGATGG	0.547		NaN											0	0	0	0.013726	0	32	26									
TSTD2	158427	broad.mit.edu	37	9	100388271	100388271	+	Silent	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:100388271G>T	uc004axn.2	-	3	662	c.174C>A	c.(172-174)GCC>GCA	p.A58A	TSTD2_uc004axo.2_5'UTR|TSTD2_uc004axp.1_5'UTR	NM_139246	NP_640339	Q5T7W7	TSTD2_HUMAN	thiosulfate sulfurtransferase (rhodanese)-like	58										ovary(2)	2						TGACAAAAAGGGCAAAGGCCT	0.353		NaN											1	0	5.9392e-07	0.001168	6.22064e-07	6	6									
SVEP1	79987	broad.mit.edu	37	9	113205828	113205828	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:113205828G>T	uc010mtz.2	-	27	4973	c.4636C>A	c.(4636-4638)CCT>ACT	p.P1546T	SVEP1_uc010mua.1_Missense_Mutation_p.P1546T	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1546	Pentaxin.			P -> PGMF (in Ref. 1; CAF04067).	cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						AACATACCAGGTATGGGCAAA	0.418		NaN											1	0	0.000157383	0.00308	0.000163846	7	6									
ZFP37	7539	broad.mit.edu	37	9	115805712	115805712	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:115805712C>A	uc004bgm.1	-	4	1214	c.1186G>T	c.(1186-1188)GTG>TTG	p.V396L	ZFP37_uc011lwz.1_Missense_Mutation_p.V411L|ZFP37_uc011lxa.1_Missense_Mutation_p.V397L	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	396	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TGAGATCTCACATGTTGAATA	0.413		NaN											1	0	5.7616e-29	0.01441	6.25504e-29	47	34									
PRPF4	9128	broad.mit.edu	37	9	116050456	116050456	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:116050456G>A	uc004bgx.2	+	10	987	c.937G>A	c.(937-939)GAT>AAT	p.D313N	PRPF4_uc004bgy.2_Missense_Mutation_p.D312N	NM_004697	NP_004688	O43172	PRP4_HUMAN	PRP4 pre-mRNA processing factor 4 homolog	313	WD 2.					Cajal body|nuclear speck|spliceosomal complex|U4/U6 snRNP	protein binding			ovary(2)|pancreas(1)	3						CCTTTCCAGTGATGAACCAGT	0.458		NaN											0	0	0	0.003163	0	13	18									
OR1B1	347169	broad.mit.edu	37	9	125391656	125391656	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:125391656C>T	uc011lyz.1	-	1	159	c.159G>A	c.(157-159)TGG>TGA	p.W53*		NM_001004450	NP_001004450	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCTGGAGTCCCAGGAGATGA	0.522		NaN											0	0	0	0.006122	0	17	12									
GARNL3	84253	broad.mit.edu	37	9	130027210	130027210	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:130027210G>A	uc011mae.1	+	1	455	c.54G>A	c.(52-54)CTG>CTA	p.L18L	GARNL3_uc011mad.1_Intron	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	GTPase activating Rap/RanGAP domain-like 3	18					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GTATAATACTGATGAAGCATT	0.453		NaN											0	0	0	0.00278	0	23	29									
TPRN	286262	broad.mit.edu	37	9	140093630	140093630	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:140093630G>A	uc004clt.2	-	1	1351	c.1351C>T	c.(1351-1353)CTG>TTG	p.L451L	TPRN_uc004clu.2_Silent_p.L451L	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	512					sensory perception of sound	stereocilium					0						TGGTCCTGCAGAGTCCCTGGC	0.672		NaN											0	0	0	0.01441	0	48	37									
FAM166A	401565	broad.mit.edu	37	9	140139108	140139108	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr9:140139108A>G	uc004cmi.1	-	5	788	c.733T>C	c.(733-735)TTC>CTC	p.F245L		NM_001001710	NP_001001710	Q6J272	F166A_HUMAN	hypothetical protein LOC401565	245										ovary(1)	1						CTCTTGTCGAATTCGTCCATG	0.577		NaN											0	0	0	0.005443	0	24	18									
SLC25A6	293	broad.mit.edu	37	X	1505571	1505571	+	Missense_Mutation	SNP	G	G	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:1505571G>T	uc004cpt.2	-	4	917	c.821C>A	c.(820-822)GCG>GAG	p.A274E	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	274	Helical; Name=6; (By similarity).|Solcar 3.				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	GTTGGACCACGCACCCTTGAA	0.607		NaN											1	0	1.19662e-71	0.01441	1.30239e-71	154	78									
ARSH	347527	broad.mit.edu	37	X	2945385	2945385	+	Silent	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:2945385T>C	uc011mhj.1	+	7	1068	c.1068T>C	c.(1066-1068)GGT>GGC	p.G356G		NM_001011719	NP_001011719	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	356						integral to membrane	arylsulfatase activity|metal ion binding			lung(1)	1		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GGGAAGGAGGTATCCGTGTGC	0.453		NaN											0	0	0	0.00623	0	36	20									
MID1	4281	broad.mit.edu	37	X	10535150	10535150	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:10535150C>T	uc004cte.3	-	2	629	c.438G>A	c.(436-438)CTG>CTA	p.L146L	MID1_uc004ctd.3_5'Flank|MID1_uc004ctg.3_Silent_p.L146L|MID1_uc004cth.3_Silent_p.L146L|MID1_uc004ctk.3_Silent_p.L146L|MID1_uc004cti.3_Silent_p.L146L|MID1_uc004ctj.3_Silent_p.L146L|MID1_uc011mie.1_RNA|MID1_uc004ctm.1_Silent_p.L146L|MID1_uc004ctn.1_Silent_p.L146L|MID1_uc004cto.1_Silent_p.L146L|MID1_uc010ndw.1_5'Flank|MID1_uc004cts.1_5'Flank|MID1_uc004ctt.2_Silent_p.L146L|MID1_uc004ctu.2_Silent_p.L146L|MID1_uc004ctv.2_Silent_p.L146L|MID1_uc004ctw.2_Silent_p.L146L|MID1_uc010ndy.1_Silent_p.L146L|uc010ndz.1_5'Flank|MID1_uc004cty.2_Silent_p.L146L|MID1_uc004ctz.1_5'Flank|MID1_uc004cua.1_RNA|MID1_uc004cub.1_Silent_p.L146L|MID1_uc010nea.1_Intron|MID1_uc004cuc.1_Silent_p.L146L|MID1_uc004cud.1_Silent_p.L146L|MID1_uc004cue.1_Silent_p.L146L|MID1_uc004cuf.1_Silent_p.L146L|MID1_uc004cug.1_Silent_p.L146L	NM_033290	NP_150632	O15344	TRI18_HUMAN	midline 1	146	B box-type 1.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			ovary(2)|pancreas(1)	3						GAGTGGCTTTCAGGCACTCGT	0.552		NaN											0	0	0	0.004289	0	38	24									
ARHGAP6	395	broad.mit.edu	37	X	11204418	11204418	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:11204418T>C	uc004cup.1	-	5	2084	c.1211A>G	c.(1210-1212)AAT>AGT	p.N404S	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.N404S|ARHGAP6_uc004cum.1_Missense_Mutation_p.N201S|ARHGAP6_uc004cun.1_Missense_Mutation_p.N224S|ARHGAP6_uc010neb.1_Missense_Mutation_p.N226S|ARHGAP6_uc011mif.1_Missense_Mutation_p.N201S	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	404	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						GTAAATAGGATTCAGACTGAG	0.428		NaN											0	0	0	0.01441	0	110	84									
AMELX	265	broad.mit.edu	37	X	11316858	11316858	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:11316858T>C	uc004cut.2	+	5	403	c.335T>C	c.(334-336)ATC>ACC	p.I112T	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.I126T|AMELX_uc004cuu.2_Missense_Mutation_p.I96T	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	112					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						ATGACTCCAATCCAACACCAC	0.642		NaN											0	0	0	0.01441	0	65	39									
RBBP7	5931	broad.mit.edu	37	X	16864054	16864054	+	Missense_Mutation	SNP	T	T	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:16864054T>A	uc004cxt.2	-	11	1464	c.1106A>T	c.(1105-1107)CAT>CTT	p.H369L	RBBP7_uc004cxs.1_Missense_Mutation_p.H413L|RBBP7_uc004cxu.2_Missense_Mutation_p.H360L	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	369	WD 6.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					GTGTCCTCCATGAATAAACTG	0.363		NaN											0	0	0	0.007291	0	31	19									
DMD	1756	broad.mit.edu	37	X	31947824	31947824	+	Silent	SNP	G	G	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:31947824G>C	uc004dda.1	-	47	7045	c.6801C>G	c.(6799-6801)CTC>CTG	p.L2267L	DMD_uc004dcr.1_5'UTR|DMD_uc004dcs.1_5'UTR|DMD_uc004dct.1_5'UTR|DMD_uc004dcu.1_5'UTR|DMD_uc004dcv.1_5'UTR|DMD_uc004dcw.2_Silent_p.L923L|DMD_uc004dcx.2_Silent_p.L926L|DMD_uc004dcz.2_Silent_p.L2144L|DMD_uc004dcy.1_Silent_p.L2263L|DMD_uc004ddb.1_Silent_p.L2259L|DMD_uc010ngn.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2267	Spectrin 16.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTAATTGTTTGAGAATTCCCT	0.423		NaN											0	0	0	0.012319	0	21	31									
KDM6A	7403	broad.mit.edu	37	X	44922802	44922802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:44922802C>T	uc004dge.3	+	16	2038	c.1663C>T	c.(1663-1665)CAG>TAG	p.Q555*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.Q521*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.Q607*|KDM6A_uc011mla.1_Nonsense_Mutation_p.Q510*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.Q562*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.Q259*|KDM6A_uc011mld.1_Nonsense_Mutation_p.Q194*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	555					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TAGCGTCTCTCAGCCTGGAGT	0.567		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.007291	0	29	24									
CHST7	56548	broad.mit.edu	37	X	46434113	46434113	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:46434113C>T	uc004dgt.2	+	1	922	c.747C>T	c.(745-747)ATC>ATT	p.I249I		NM_019886	NP_063939	Q9NS84	CHST7_HUMAN	chondroitin 6-sulfotransferase 7	249	Lumenal (Potential).				chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)	3						TGGTGGTCATCAAGGACGTGC	0.682		NaN											0	0	0	0.010729	0	12	14									
OTUD5	55593	broad.mit.edu	37	X	48780496	48780496	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:48780496C>T	uc004dlu.2	-	9	1732	c.1671G>A	c.(1669-1671)ATG>ATA	p.M557I	OTUD5_uc004dlt.3_Missense_Mutation_p.M552I|OTUD5_uc004dlv.2_Missense_Mutation_p.M552I|OTUD5_uc011mmp.1_Missense_Mutation_p.M335I	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	557					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						TGTTTTTCTTCATACTGTCTA	0.532		NaN											0	0	0	0.003271	0	33	26									
GPKOW	27238	broad.mit.edu	37	X	48973498	48973498	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:48973498C>T	uc004dmr.2	-	6	806	c.799G>A	c.(799-801)GAC>AAC	p.D267N		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	267	KOW 1.					nucleus	nucleic acid binding			ovary(2)	2						CGAACATTGTCAGGATCAAGG	0.547		NaN											0	0	0	0.004878	0	36	23									
IQSEC2	23096	broad.mit.edu	37	X	53268459	53268459	+	Missense_Mutation	SNP	C	C	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:53268459C>A	uc004dsd.2	-	11	3234	c.3033G>T	c.(3031-3033)CAG>CAT	p.Q1011H	IQSEC2_uc004dsc.2_Missense_Mutation_p.Q806H	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	1001	PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						TCTTCTTCTTCTGGAAAATTT	0.498		NaN									OREG0019800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	0.000308642	0.003163	0.000319004	14	27									
PFKFB1	5207	broad.mit.edu	37	X	54959877	54959877	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:54959877C>T	uc004dty.1	-	14	1446	c.1375G>A	c.(1375-1377)GAA>AAA	p.E459K	PFKFB1_uc010nkd.1_Missense_Mutation_p.E267K|PFKFB1_uc011mol.1_Missense_Mutation_p.E394K	NM_002625	NP_002616	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,	459	Fructose-2,6-bisphosphatase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(1)	1						TCCTCAGGTTCCCGGGTGATG	0.552		NaN											0	0	0	0.004656	0	27	16									
APEX2	27301	broad.mit.edu	37	X	55028739	55028739	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:55028739G>A	uc004dtz.2	+	3	373	c.297G>A	c.(295-297)CTG>CTA	p.L99L	APEX2_uc011mom.1_Intron	NM_014481	NP_055296	Q9UBZ4	APEX2_HUMAN	apurinic/apyrimidinic endonuclease 2	99					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)	1						AAGAAGGCCTGAGTGGCCTGT	0.552		NaN						Other_BER_factors					0	0	0	0.01441	0	46	20									
UBQLN2	29978	broad.mit.edu	37	X	56591246	56591246	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:56591246G>A	uc004dus.2	+	1	1175	c.940G>A	c.(940-942)GAT>AAT	p.D314N	UBQLN2_uc011moq.1_Missense_Mutation_p.D314N	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	314						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						AGAAAATCGCGATCCACTACC	0.567		NaN											0	0	0	0.005443	0	27	20									
KIAA2022	340533	broad.mit.edu	37	X	73963126	73963126	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:73963126C>T	uc004eby.2	-	3	1883	c.1266G>A	c.(1264-1266)AAG>AAA	p.K422K		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	422					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GCTTTGGATTCTTAAGTTGCT	0.428		NaN											0	0	0	0.014323	0	21	39									
MAGEE2	139599	broad.mit.edu	37	X	75003930	75003930	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:75003930G>A	uc004ecj.1	-	1	1142	c.957C>T	c.(955-957)GTC>GTT	p.V319V		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	319	MAGE 2.									ovary(1)|skin(1)	2						TAGCCAACTGGACCAAATCAT	0.453		NaN											0	0	0	0.012319	0	18	35									
TNMD	64102	broad.mit.edu	37	X	99854576	99854576	+	Silent	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:99854576C>T	uc004efy.3	+	7	1042	c.816C>T	c.(814-816)GGC>GGT	p.G272G	TNMD_uc004efz.2_3'UTR	NM_022144	NP_071427	Q9H2S6	TNMD_HUMAN	tenomodulin	272	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						GCCGTCGAGGCAACCGCTATT	0.478		NaN											0	0	0	0.001984	0	5	16									
TSPAN6	7105	broad.mit.edu	37	X	99888412	99888412	+	Missense_Mutation	SNP	A	A	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:99888412A>T	uc004ega.1	-	5	678	c.575T>A	c.(574-576)GTA>GAA	p.V192E	TSPAN6_uc010nna.1_Missense_Mutation_p.V98E	NM_003270	NP_003261	O43657	TSN6_HUMAN	transmembrane 4 superfamily member 6	192	Extracellular (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	signal transducer activity			ovary(1)	1						TTCATTGTTTACTTTGTCTGC	0.294		NaN											0	0	0	0.004007	0	14	32									
MORC4	79710	broad.mit.edu	37	X	106219839	106219839	+	Missense_Mutation	SNP	C	C	T			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:106219839C>T	uc004emu.3	-	9	1375	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.D378N|MORC4_uc004emw.3_Missense_Mutation_p.D126N	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	378							ATP binding|zinc ion binding			ovary(1)	1						TACTCAAAGTCTTGTTTGTTG	0.408		NaN											0	0	0	0.003163	0	13	43									
MID2	11043	broad.mit.edu	37	X	107084505	107084505	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:107084505A>G	uc004enl.2	+	2	1183	c.610A>G	c.(610-612)AAC>GAC	p.N204D	MID2_uc004enk.2_Missense_Mutation_p.N204D	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	204	B box-type 2.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TGAGAAAGTGAACATGTACTG	0.507		NaN											0	0	0	0.00333	0	25	39									
WDR44	54521	broad.mit.edu	37	X	117543582	117543582	+	Missense_Mutation	SNP	A	A	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:117543582A>G	uc004eqn.2	+	11	2089	c.1664A>G	c.(1663-1665)AAT>AGT	p.N555S	WDR44_uc004eqo.2_Missense_Mutation_p.N555S|WDR44_uc011mtr.1_Missense_Mutation_p.N530S|WDR44_uc010nqi.2_Missense_Mutation_p.N265S	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	555						cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						ATGAAATACAATACTGAAGGT	0.348		NaN											0	0	0	0.007413	0	19	41									
ZCCHC12	170261	broad.mit.edu	37	X	117960326	117960326	+	Silent	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:117960326G>A	uc004equ.2	+	4	1592	c.1119G>A	c.(1117-1119)TTG>TTA	p.L373L		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						TTGAGAATTTGATCATCACTC	0.502		NaN											0	0	0	0.00499	0	16	26									
SASH3	54440	broad.mit.edu	37	X	128922525	128922525	+	Missense_Mutation	SNP	T	T	C			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:128922525T>C	uc011mun.1	+	3	454	c.272T>C	c.(271-273)ATG>ACG	p.M91T	SASH3_uc004euu.2_Missense_Mutation_p.M91T|SASH3_uc011muo.1_Missense_Mutation_p.M8T	NM_018990	NP_061863	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	91										ovary(2)|pancreas(1)	3						ATGGGCAAGATGATGGTGAAG	0.572		NaN											0	0	0	0.003163	0	11	23									
MAGEA11	4110	broad.mit.edu	37	X	148797576	148797576	+	Missense_Mutation	SNP	G	G	A			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:148797576G>A	uc004fdq.2	+	5	532	c.430G>A	c.(430-432)GAG>AAG	p.E144K	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.E115K	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	144						cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					TCTCCAAGCTGAGGAGCAGGA	0.577		NaN											0	0	0	0.008291	0	10	28									
INSRR	3645	broad.mit.edu	37	1	156818798	156818798	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr1:156818798delC	uc010pht.1	-	7	1740	c.1486delG	c.(1486-1488)GCAfs	p.A496fs	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	496	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ATGCGGTCTGCCTCCGTCACG	0.637		NaN											NaN	NaN	NaN	NaN	NaN	22	26	---	---							
CCNY	219771	broad.mit.edu	37	10	35842099	35842100	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:35842099_35842100delCA	uc001iyw.3	+	8	912_913	c.732_733delCA	c.(730-735)ATCACGfs	p.I244fs	CCNY_uc001iyu.3_Frame_Shift_Del_p.I190fs|CCNY_uc001iyv.3_Frame_Shift_Del_p.I190fs|CCNY_uc001iyx.3_Frame_Shift_Del_p.I190fs|CCNY_uc009xmb.2_Frame_Shift_Del_p.I219fs|CCNY_uc010qet.1_Frame_Shift_Del_p.I111fs	NM_145012	NP_659449	Q8ND76	CCNY_HUMAN	cyclin Y isoform 1	244_245	Cyclin N-terminal.				cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding				0						TGAAAGACATCACGGTGGAGGA	0.515		NaN											NaN	NaN	NaN	NaN	NaN	23	58	---	---							
P4HA1	5033	broad.mit.edu	37	10	74813169	74813169	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr10:74813169delC	uc010qka.1	-	7	977	c.643delG	c.(643-645)GTAfs	p.V215fs	P4HA1_uc001jtg.2_Frame_Shift_Del_p.V215fs|P4HA1_uc001jth.2_Frame_Shift_Del_p.V215fs|P4HA1_uc010qkb.1_Frame_Shift_Del_p.V215fs|P4HA1_uc001jti.2_RNA	NM_001142595	NP_001136067	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha I subunit isoform 2	215	TPR.					endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGCTGATATACCGCATAGCTC	0.413		NaN											NaN	NaN	NaN	NaN	NaN	14	68	---	---							
MLL	4297	broad.mit.edu	37	11	118359411	118359411	+	Frame_Shift_Del	DEL	A	A	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08			A	-	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr11:118359411delA	uc001pta.2	+	11	4438	c.4415delA	c.(4414-4416)GAAfs	p.E1472fs	MLL_uc001ptb.2_Frame_Shift_Del_p.E1472fs|MLL_uc001pte.1_RNA	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1472	PHD-type 1.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GACCAGCTGGAAAATTGGTGT	0.418		NaN	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								NaN	NaN	NaN	NaN	NaN	24	28	---	---							
NTS	4922	broad.mit.edu	37	12	86276100	86276112	+	Frame_Shift_Del	DEL	GAGAATAAACCCA	GAGAATAAACCCA	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr12:86276100_86276112delGAGAATAAACCCA	uc001tag.2	+	4	567_579	c.460_472delGAGAATAAACCCA	c.(460-474)GAGAATAAACCCAGAfs	p.E154fs		NM_006183	NP_006174	P30990	NEUT_HUMAN	neurotensin/neuromedin N preproprotein	154_158					regulation of blood vessel size|signal transduction	extracellular region|soluble fraction|transport vesicle	neuropeptide hormone activity				0						GCAGCTGTATGAGAATAAACCCAGAAGACCCTA	0.31		NaN											NaN	NaN	NaN	NaN	NaN	10	86	---	---							
EFCAB5	374786	broad.mit.edu	37	17	28384744	28384759	+	Frame_Shift_Del	DEL	AGAACTGCCTTCAATG	AGAACTGCCTTCAATG	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:28384744_28384759delAGAACTGCCTTCAATG	uc002het.2	+	13	2608_2623	c.2416_2431delAGAACTGCCTTCAATG	c.(2416-2433)AGAACTGCCTTCAATGGAfs	p.R806fs	EFCAB5_uc010wbj.1_Frame_Shift_Del_p.R750fs|EFCAB5_uc010wbk.1_Frame_Shift_Del_p.R463fs|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Intron|EFCAB5_uc010csf.2_Frame_Shift_Del_p.R685fs	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	806_811							calcium ion binding			ovary(1)|skin(1)	2						GGTAAAAGGCAGAACTGCCTTCAATGGAGTTTCATT	0.403		NaN											NaN	NaN	NaN	NaN	NaN	10	58	---	---							
SOCS7	30837	broad.mit.edu	37	17	36551570	36551570	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:36551570delC	uc002hqa.2	+	8	1621	c.1498delC	c.(1498-1500)CCAfs	p.P500fs	SOCS7_uc010cvl.2_Frame_Shift_Del_p.P466fs|SOCS7_uc002hqb.2_Intron	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	500	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					AGGACTGCCACCAACTCCTGT	0.468		NaN											NaN	NaN	NaN	NaN	NaN	13	31	---	---							
ITGA2B	3674	broad.mit.edu	37	17	42462950	42462957	+	Frame_Shift_Del	DEL	GGTGTTCC	GGTGTTCC	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr17:42462950_42462957delGGTGTTCC	uc002igt.1	-	4	568_575	c.536_543delGGAACACC	c.(535-543)GGGAACACCfs	p.G179fs		NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	179_181	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	TGCGGCTCAGGGTGTTCCCGCGACAGGG	0.635		NaN											NaN	NaN	NaN	NaN	NaN	7	8	---	---							
SYDE1	85360	broad.mit.edu	37	19	15223296	15223296	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:15223296delC	uc002nah.1	+	7	1749	c.1718delC	c.(1717-1719)GCCfs	p.A573fs	SYDE1_uc002nai.1_Frame_Shift_Del_p.A506fs|SYDE1_uc002naj.1_Frame_Shift_Del_p.A230fs	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	573	Rho-GAP.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2						AGGCCTCGTGCCCGCAGCTCC	0.647		NaN											NaN	NaN	NaN	NaN	NaN	12	14	---	---							
HNRNPUL1	11100	broad.mit.edu	37	19	41808719	41808745	+	In_Frame_Del	DEL	GGTGGTGGTGGCTTCCGGGGCCGCGGG	GGTGGTGGTGGCTTCCGGGGCCGCGGG	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr19:41808719_41808745delGGTGGTGGTGGCTTCCGGGGCCGCGGG	uc002oqb.3	+	12	2126_2152	c.1837_1863delGGTGGTGGTGGCTTCCGGGGCCGCGGG	c.(1837-1863)GGTGGTGGTGGCTTCCGGGGCCGCGGGdel	p.GGGGFRGRG613del	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc002oqa.3_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010ehm.2_In_Frame_Del_p.GGGGFRGRG613del|HNRNPUL1_uc002oqc.3_In_Frame_Del_p.GGGGFRGRG499del|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010ehn.2_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010eho.2_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010xvy.1_In_Frame_Del_p.GGGGFRGRG513del|HNRNPUL1_uc010ehp.2_In_Frame_Del_p.GGGGFRGRG469del|HNRNPUL1_uc002oqf.3_In_Frame_Del_p.GGGGFRGRG137del	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	613_621	Necessary for transcription repression.|Necessary for interaction with TP53.|Gly-rich.|1-2.|5 X 3 AA repeats of R-G-G.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						TGACAACCGAGGTGGTGGTGGCTTCCGGGGCCGCGGGGGTGGTGGTG	0.652		NaN											NaN	NaN	NaN	NaN	NaN	10	47	---	---							
ZNF513	130557	broad.mit.edu	37	2	27601758	27601758	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:27601758delC	uc002rkk.2	-	3	575	c.375delG	c.(373-375)GGGfs	p.G125fs	ZNF513_uc002rkj.2_Frame_Shift_Del_p.G63fs	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	125	Gly-rich.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTGTCGGCCCCCCACACA	0.706		NaN											NaN	NaN	NaN	NaN	NaN	6	9	---	---							
COL6A3	1293	broad.mit.edu	37	2	238277474	238277475	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr2:238277474_238277475delCA	uc002vwl.2	-	10	4916_4917	c.4631_4632delTG	c.(4630-4632)CTGfs	p.L1544fs	COL6A3_uc002vwo.2_Frame_Shift_Del_p.L1338fs|COL6A3_uc010znj.1_Frame_Shift_Del_p.L937fs	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1544	VWFA 8.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGACCAGGACCAGGTGTTGGGG	0.569		NaN											NaN	NaN	NaN	NaN	NaN	23	125	---	---							
C22orf28	51493	broad.mit.edu	37	22	32797844	32797858	+	In_Frame_Del	DEL	GGTTCTTAGCAAGCG	GGTTCTTAGCAAGCG	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:32797844_32797858delGGTTCTTAGCAAGCG	uc003amm.2	-	5	504_518	c.373_387delCGCTTGCTAAGAACC	c.(373-387)CGCTTGCTAAGAACCdel	p.RLLRT125del	C22orf28_uc011ama.1_RNA	NM_014306	NP_055121	Q9Y3I0	RTCB_HUMAN	hypothetical protein LOC51493	125_129					cell-matrix adhesion|substrate adhesion-dependent cell spreading|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|tRNA-splicing ligase complex	ATP binding|metal ion binding|RNA ligase (ATP) activity|vinculin binding				0						CATCTAAATTGGTTCTTAGCAAGCGGACACCACAG	0.465		NaN											NaN	NaN	NaN	NaN	NaN	10	36	---	---							
PLXNB2	23654	broad.mit.edu	37	22	50719219	50719220	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr22:50719219_50719220insG	uc003bkv.3	-	24	4052_4053	c.3946_3947insC	c.(3946-3948)CTCfs	p.L1316fs	PLXNB2_uc003bkt.1_Frame_Shift_Ins_p.L108fs|PLXNB2_uc003bku.1_Frame_Shift_Ins_p.L301fs	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1316	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GAACTGGTAGAGGGCCTGCTCC	0.653		NaN											NaN	NaN	NaN	NaN	NaN	9	36	---	---							
ULK4	54986	broad.mit.edu	37	3	41860995	41860995	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:41860995delC	uc003ckv.3	-	19	1969	c.1768delG	c.(1768-1770)GAAfs	p.E590fs	ULK4_uc003ckw.2_Frame_Shift_Del_p.E590fs	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	590							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TTTTTTTTTTCTTCCTAAAAT	0.438		NaN											NaN	NaN	NaN	NaN	NaN	24	82	---	---							
MINA	84864	broad.mit.edu	37	3	97686358	97686359	+	In_Frame_Ins	INS	-	-	CTGCTT			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr3:97686358_97686359insCTGCTT	uc003drz.1	-	2	585_586	c.79_80insAAGCAG	c.(79-81)GCT>GAAGCAGCT	p.26_27insEA	MINA_uc003dsa.1_In_Frame_Ins_p.26_27insEA|MINA_uc003dsb.1_In_Frame_Ins_p.26_27insEA|MINA_uc003dsc.1_In_Frame_Ins_p.26_27insEA|MINA_uc010hpa.1_RNA|MINA_uc010hpb.1_Intron	NM_001042533	NP_001035998	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen isoform a	26_27					ribosome biogenesis	cytoplasm|nucleolus				ovary(1)	1						AGGCCCCCCAGCTGCTTCTAAC	0.48		NaN											NaN	NaN	NaN	NaN	NaN	9	73	---	---							
NFE2L3	9603	broad.mit.edu	37	7	26223328	26223340	+	Frame_Shift_Del	DEL	TGAATGGGACAGA	TGAATGGGACAGA	-	rs150480522		TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:26223328_26223340delTGAATGGGACAGA	uc003sxq.2	+	3	1030_1042	c.758_770delTGAATGGGACAGA	c.(757-771)CTGAATGGGACAGATfs	p.L253fs		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	253_257					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						CAGAGACATCTGAATGGGACAGATACTTCTTTC	0.394		NaN											NaN	NaN	NaN	NaN	NaN	11	69	---	---							
SFRP4	6424	broad.mit.edu	37	7	37947153	37947153	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chr7:37947153delG	uc003tfo.3	-	6	1355	c.969delC	c.(967-969)CCCfs	p.P323fs		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	323					brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						TGGCTGGTTTGGGAGCAGGAG	0.512		NaN											NaN	NaN	NaN	NaN	NaN	45	121	---	---							
USP9X	8239	broad.mit.edu	37	X	41047370	41047371	+	Splice_Site	INS	-	-	GT			TCGA-BT-A2LB-01A-11D-A18F-08	TCGA-BT-A2LB-10A-01D-A18F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e7aea186-f13b-43b1-8693-f90f51e005dd	9e1dc9d9-4f0f-4083-92d2-4ddf816088ef	g.chrX:41047370_41047371insGT	uc004dfb.2	+	25	4443	c.3810_splice	c.e25+1	p.K1270_splice	USP9X_uc004dfc.2_Splice_Site_p.K1270_splice	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform						BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TTTATGAGAAGGTAAGAATTAT	0.297		NaN											NaN	NaN	NaN	NaN	NaN	19	15	---	---