RAD51B (RAD51 paralog B)

Gene Basic Information

Gene Basic Information

symbol:
RAD51B
locus group:
protein-coding gene
location:
14q24.1
gene_family:
alias symbol:
REC2|hREC2|R51H2
alias name:
None
entrez id:
5890
ensembl gene id:
ENSG00000182185
ucsc gene id:
uc001xkd.4
refseq accession:
NM_001321809
hgnc_id:
HGNC:9822
approved reserved:
1997-09-12

Chromosome Location

Chromosome Location

14q24.1

Gene Summary

Gene Summary

RAD51B属于RAD51基因家族，该家族在DNA同源重组修复（HRR）过程中起关键作用，主要参与维持基因组稳定性。RAD51B编码的蛋白与RAD51、RAD51C、RAD51D等家族成员形成复合物，共同促进DNA双链断裂（DSB）修复中的链交换反应。该基因在减数分裂和有丝分裂中均发挥重要作用，尤其在生殖细胞和快速增殖的体细胞（如造血干细胞）中表达较高。RAD51B蛋白通过结合单链DNA并介导同源搜索和链入侵，确保DNA损伤的正确修复。若RAD51B发生功能丧失性突变（如错义突变或截短突变），会导致HRR缺陷，引发染色体不稳定、易位或断裂，增加癌症风险（如乳腺癌、卵巢癌）。此外，RAD51B突变还与范可尼贫血等遗传病相关，表现为骨髓衰竭和发育异常。当RAD51B过表达时，可能增强DNA修复能力但同时也可能促进肿瘤细胞对放化疗的抵抗；而低表达或缺失则导致修复功能受损，使细胞对DNA损伤剂（如PARP抑制剂）敏感，这一特性被用于合成致死疗法。RAD51基因家族的共性包括：均含保守的RecA结构域，形成丝状核蛋白复合物，依赖ATP水解完成DNA重组，且多数成员（如RAD51A-D）存在物理相互作用。研究还发现RAD51B与XRCC2、XRCC3等非家族蛋白协作，其表达水平受ATM/ATR等DNA损伤应答通路调控。

ChineseEnglish

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Jul 2011]

OMIM entry for RAD51B     Wikipedia entry for RAD51B

Gene Sequence

Gene Sequence

Nucleotide sequence of RAD51B:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MGSKKLKRVG LSQELCDRLS RHQILTCQDF LCLSPLELMK
41VTGLSYRGVH ELLCMVSRAC APKMQTAYGI KAQRSADFSP
81 AFLSTTLSA LDEALHGGVA CGSLTEITGP PGCGKTQFCI
121MMSILATLPT NMGGLEGAVV YIDTESAFSA ERLVEIAESR
161F PRYFNTEE KLLLTSSKVH LYRELTCDEV LQRIESLEEE
201IISKGIKLVI LDSVASVVRK EFDAQLQGNL KERNKFLARE
241AS SLKYLAE EFSIPVILTN QITTHLSGAL ASQADLVSPA
281DDLSLSEGTS GSSCVIAALG NTWSHSVNTR LILQYLDSER
321RQI LIAKSP LAPFTSFVYT IKEEGLVLQE TTFCSVTQAE
361LNWAPEILPP QPPEQLGLQM CHHTQLIF
结构预测来自 AlphaFold DB（UniProt: O15315），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of RAD51B:           Showing partial SNPs
rs724535       rs761951       rs767127       rs1055840       rs1055841       rs1474960       rs1547010       rs1547011       rs1884807       rs1884808       rs1884809       rs1884810       rs1884811       rs2024944       rs2024945       rs2064825       rs2064826      

Gene Expression

Gene Expression

Tissue expression of RAD51B:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CCTGTGATGAAGTTCTACAAAGG
60
AGCAACAGAGTCAAGAATCAC
59
TACAACCCATCTGAGTGGAG
59
CAGAAGTGCCTTCAGACAG
58
GAGAAGACAGATTCTTATTGCC
57
TGGTGTAGACAAATGAGGTG
58
TTACCCACCAACATGGGAG
59
TTCAACCAGTCTTTCAGCAC
59
TGTCTGAAGGCACTTCTGG
60
ATCAGCCGGGTATTCACAC
60
CTGAGTTATCGAGGTGTCCA
59
TATCCCATAAGCCGTTTGCA
60
CTAGTGGAGAGGCCAAGAG
59
TCTTCCAAGCAGTACGGTC
59
CATTGTAAAGAAGTTCCACCAG
58
TTCAGCTTGGGTGACAGAG
60
TACAACCCATCTGAGTGGA
58
CAGAAGTGCCTTCAGACAG
58
GGAAATACCTGGAGTCACAG
58
GGCAATAAGAATCTGTCTTCTC
57

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
GTF3A
RAD51B
Unknown
9878257
TP53
RAD51B
Unknown
9878257

Gene Ontology

Subcellular localization of RAD51B (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for RAD51B:

GO ID
Protein
Source DB
GO:0000724
A0A0A0MS18 (UniProtKB)
IEA
GO:0003677
A0A0A0MS18 (UniProtKB)
IEA
GO:0005524
A0A0A0MS18 (UniProtKB)
IEA
GO:0008094
A0A0A0MS18 (UniProtKB)
IEA
GO:0016021
A0A0A0MS18 (UniProtKB)
IEA
GO:0033063
A0A0A0MS18 (UniProtKB)
IEA
GO:0000724
C9J5S9 (UniProtKB)
IEA
GO:0003677
C9J5S9 (UniProtKB)
IEA
GO:0005524
C9J5S9 (UniProtKB)
IEA
GO:0008094
C9J5S9 (UniProtKB)
IEA
GO:0033063
C9J5S9 (UniProtKB)
IEA
GO:0000724
C9JYJ0 (UniProtKB)
IEA
GO:0003677
C9JYJ0 (UniProtKB)
IEA
GO:0005524
C9JYJ0 (UniProtKB)
IEA
GO:0008094
C9JYJ0 (UniProtKB)
IEA
GO:0033063
C9JYJ0 (UniProtKB)
IEA
GO:0000724
F8WAY6 (UniProtKB)
IEA
GO:0003677
F8WAY6 (UniProtKB)
IEA
GO:0005524
F8WAY6 (UniProtKB)
IEA
GO:0008094
F8WAY6 (UniProtKB)
IEA
GO:0033063
F8WAY6 (UniProtKB)
IEA
GO:0000724
G3V4W9 (UniProtKB)
IEA
GO:0003677
G3V4W9 (UniProtKB)
IEA
GO:0033063
G3V4W9 (UniProtKB)
IEA
GO:0000150
O15315 (UniProtKB)
IBA
GO:0000707
O15315 (UniProtKB)
IBA
GO:0000724
O15315 (UniProtKB)
IMP
GO:0000731
O15315 (UniProtKB)
TAS
GO:0000732
O15315 (UniProtKB)
TAS
GO:0001832
O15315 (UniProtKB)
IEA
GO:0003677
O15315 (UniProtKB)
TAS
GO:0003690
O15315 (UniProtKB)
IDA
GO:0003697
O15315 (UniProtKB)
IDA
GO:0005515
O15315 (UniProtKB)
IPI
GO:0005515
O15315 (UniProtKB)
IPI
GO:0005515
O15315 (UniProtKB)
IPI
GO:0005515
O15315 (UniProtKB)
IPI
GO:0005515
O15315 (UniProtKB)
IPI
GO:0005515
O15315 (UniProtKB)
IPI
GO:0005515
O15315 (UniProtKB)
IPI
GO:0005515
O15315 (UniProtKB)
IPI
GO:0005524
O15315 (UniProtKB)
IEA
GO:0005634
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005654
O15315 (UniProtKB)
TAS
GO:0005657
O15315 (UniProtKB)
IDA
GO:0006281
O15315 (UniProtKB)
TAS
GO:0006310
O15315 (UniProtKB)
TAS
GO:0006312
O15315 (UniProtKB)
IBA
GO:0007131
O15315 (UniProtKB)
TAS
GO:0007596
O15315 (UniProtKB)
TAS
GO:0008094
O15315 (UniProtKB)
IDA
GO:0008284
O15315 (UniProtKB)
IEA
GO:0010212
O15315 (UniProtKB)
IBA
GO:0010971
O15315 (UniProtKB)
IMP
GO:0033063
O15315 (UniProtKB)
IDA
GO:0042148
O15315 (UniProtKB)
IBA
GO:0061053
O15315 (UniProtKB)
IEA
GO:0000400
O15315 (UniProtKB)
IDA
GO:0004520
O15315 (UniProtKB)
IBA

Related microRNA

Related microRNA

microRNAs potentially regulating RAD51B:     

Gene Interactions

Gene Interactions

BioGrid
IntAct
mentha
MINT
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Malignant neoplasm of breast 0.132453989 15 26 BeFree_GAD_GWASCAT
Mammary Neoplasms 0.122367032 2 0 CTD_human_GAD
Age related macular degeneration 0.120542884 3 2 BeFree_GWASCAT
Rheumatoid Arthritis 0.120271442 2 1 BeFree_GWASCAT
Substance-Related Disorders 0.12 1 0 CTD_human
Primary biliary cirrhosis 0.12 1 1 GWASCAT
Breast Neoplasms, Male 0.12 1 0 CTD_human
Malignant neoplasm of prostate 0.12 1 1 GWASCAT
Hamartoma 0.003267234 2 0 BeFree_LHGDN
Breast Carcinoma 0.002985861 11 23 BeFree

Related Publications

Related Publications

BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments.
Koo CW, Xiao J, Coassolo S, Liu J, Yu C, Azumaya CM, Gore SK, Cheung TK, Brillantes B, Rose CM, Heyer WD, Ciferri C, Yatskevich S Nature IF: 56.1 2026-05-00
Genome-Wide Association Study and Genomic Selection for Average Daily Gain in Ashidan Yak.
Wang Z, Ma X, Hu G, Jing J, La Y, Ren W, Zhou B, Li H, Chu M, Wu X, Yan P, Guo X, Liang C Animals (Basel) IF: 3.2 2026-08-07
Integrated transcriptomic and epigenomic profiling reveals conserved molecular subtypes across systemic autoimmune diseases.
Fan Y, Su M, Yu L, Chen S, Zheng K, Lin J, Lin Q, Zhang W, Zheng S, Zhou Z, Zhang S, Yuan X, Matucci-Cerinic M, Furst DE, Zhang G, Wang Y Ann Rheum Dis IF: 24.0 2026-05-30
Investigating the shared genetic architecture between selective immunoglobulin A deficiency and autoimmune diseases.
Dang X, Wang FQ, Zhang C, Su H, Lei Y, Yang J, Lau YL, Yang W Hum Genet IF: 3.4 2026-06-22
Particulate Hexavalent Chromium Inhibits RAD51 Paralogs Necessary for RAD51 Filament Formation and Stabilization During Homologous Recombination Repair.
Williams AR, Meaza I, Lu H, Wise JTF, Diven SS, Toyoda JH, Kouokam JC, Wise JP Occup Health (Auckl) 2026-03-00
Cancer mutations in RAD51 and its paralogues.
Valentine AL, Huth IL, Duff NM, Rabbani AZ, Donahue KN, Bush WA, Bouley RA, Petreaca RC PLoS One IF: 2.6 None
The DNA helicase HELQ promotes replication fork reversal in coordination with BRCA2- and FANCD2-mediated repair pathways.
Dunbayev Y, Chen YJ, Sassi L, Lee EA, Ra JS, Choi M, Mukherjee A, Vasquez KM, Costanzo V, Chi P, Takata KI Nucleic Acids Res IF: 15.0 2026-04-23
Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients.
Bu R, Siraj AK, Abdul Razzaq EA, Iqbal K, Parvathareddy SK, Azam S, Qadri Z, Thangavel S, Haqawi W, Al-Kuraya KS Sci Rep IF: 4.9 2026-05-07
A comprehensive genomic framework for identifying genes predisposing to homologous recombination repair-deficient breast or ovarian cancer.
Camacho-Valenzuela J, Matis T, Roca C, Cuamatzi Flores JL, Hamel N, Rivera B, Gravel S, Polak P, Robles-Espinoza CD, Foulkes WD BJC Rep 2026-04-08

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