IL12B (interleukin 12B)

基因基本信息

基因基本信息

symbol:
IL12B
locus group:
protein-coding gene
location:
5q33.3
gene_family:
Immunoglobulin-like domain containing|Interleukins
alias symbol:
CLMF|IL-12B|NKSF|CLMF2
alias name:
natural killer cell stimulatory ...
entrez id:
3593
ensembl gene id:
ENSG00000113302
ucsc gene id:
uc003lxr.2
refseq accession:
NM_002187
hgnc_id:
HGNC:5970
approved reserved:
1991-08-08

基因染色体位置

基因染色体位置

5q33.3

基因简述

基因简述

IL12B基因编码白细胞介素12的p40亚基，是IL-12和IL-23细胞因子的共同组成部分，主要由树突状细胞和巨噬细胞等抗原呈递细胞产生。它在免疫系统中发挥核心作用，通过激活Th1型免疫反应促进干扰素γ（IFN-γ）的产生，从而增强对细胞内病原体的防御能力。IL12B属于IL-12细胞因子家族，该家族成员均以异源二聚体形式存在并参与调节先天和适应性免疫应答。IL12B的突变可能导致免疫功能异常，如增加对分枝杆菌感染的易感性，而某些IL12B多态性与自身免疫性疾病如银屑病、炎症性肠病的发病风险相关。过表达IL12B可能引发过度炎症反应，导致组织损伤或自身免疫疾病；而表达降低则可能削弱抗感染免疫，增加感染风险。IL12B的表达水平还影响其他免疫相关基因如IFNG、TNF的表达，形成复杂的免疫调控网络。在癌症免疫治疗中，IL12B的调控受到关注，因其既能增强抗肿瘤免疫又可能促进免疫相关不良反应。

中文English

这个基因编码白细胞介素12，作用于T和自然杀伤细胞的细胞因子的一个亚单位，并且具有生物活性的广泛阵列。白细胞介素12是像由该基因编码亚基的40kD的细胞因子受体所组成的二硫键连接的异二聚体，和一个35 kD的亚基通过IL12A编码。这种细胞因子通过激活巨噬细胞作为Th1细胞发展的一个重要诱导表达。这种细胞因子已被发现是用于维持足够数量的记忆/效应Th1细胞介导长期保护的细胞内病原体重要。在患有多发性硬化（MS）在中枢神经系统中观察到这种基因的过表达，这表明该细胞因子在疾病的发病机理中的作用。该基因的启动子多态性已被报道与小儿过敏性和非过敏性哮喘的严重程度相关联。 [由RefSeq的，2008年7月提供]

OMIM数据库中对IL12B基因的介绍     Wikipedia数据库中对IL12B基因的介绍

基因序列

基因序列

IL12B基因的碱基序列：[NCBI]
Loading Gene Browser...

编码蛋白质

编码蛋白质

蛋白质序列
1MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD
41APGEMVVLTC DTPEEDGITW TLDQSSEVLG SGKTLTIQVK
81 EFGDAGQYT CHKGGEVLSH SLLLLHKKED GIWSTDILKD
121QKEPKNKTFL RCEAKNYSGR FTCWWLTTIS TDLTFSVKSS
161R GSSDPQGV TCGAATLSAE RVRGDNKEYE YSVECQEDSA
201CPAAEESLPI EVMVDAVHKL KYENYTSSFF IRDIIKPDPP
241KN LQLKPLK NSRQVEVSWE YPDTWSTPHS YFSLTFCVQV
281QGKSKREKKD RVFTDKTSAT VICRKNASIS VRAQDRYYSS
321SWS EWASVP CS
结构预测来自 AlphaFold DB（UniProt: P29460），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

基因突变

基因突变

IL12B基因的碱基突变：           仅显示部分snp
rs730690       rs730691       rs889058       rs919766       rs1003199       rs1368439       rs1433048       rs1805132       rs2195940       rs2288831       rs2421047       rs2546891       rs2546892       rs2546893       rs2569253       rs2569254       rs2853694      

基因表达

基因表达

IL12B基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CCATTGAGGTCATGGTGGA
59
GTCAGGTTTGATGATGTCCC
59
CCATTGAGGTCATGGTGGA
59
TCAGGTTTGATGATGTCCCT
59
CCATTGAGGTCATGGTGGA
59
CAGGTTTGATGATGTCCCTG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
EP300
IL12B
Activation
15482860
ETS2
IL12B
Unknown
10657616
IRF1
IL12B
Unknown
10657616
JUN
IL12B
Activation
14688340
KLF1
IL12B
Unknown
14976188
NFKB1
IL12B
Activation
14688340; 18690006
NFKB1
IL12B
Unknown
10657616
REL
IL12B
Unknown
10657616
RELA
IL12B
Activation
14688340; 18690006
RELA
IL12B
Unknown
10657616; 15270850

基因本体信息

IL12B基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

IL12B基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001916
P29460 (UniProtKB)
ISS
GO:0002230
P29460 (UniProtKB)
ISS
GO:0002230
P29460 (UniProtKB)
IDA
GO:0002323
P29460 (UniProtKB)
IEA
GO:0002827
P29460 (UniProtKB)
ISS
GO:0002827
P29460 (UniProtKB)
IDA
GO:0002860
P29460 (UniProtKB)
IDA
GO:0002862
P29460 (UniProtKB)
IEA
GO:0004896
P29460 (UniProtKB)
IEA
GO:0005143
P29460 (UniProtKB)
TAS
GO:0005515
P29460 (UniProtKB)
IPI
GO:0005515
P29460 (UniProtKB)
IPI
GO:0005515
P29460 (UniProtKB)
IPI
GO:0005515
P29460 (UniProtKB)
IPI
GO:0005515
P29460 (UniProtKB)
IPI
GO:0005515
P29460 (UniProtKB)
IPI
GO:0005515
P29460 (UniProtKB)
IPI
GO:0005576
P29460 (UniProtKB)
TAS
GO:0005576
P29460 (UniProtKB)
TAS
GO:0005576
P29460 (UniProtKB)
TAS
GO:0005615
P29460 (UniProtKB)
TAS
GO:0005737
P29460 (UniProtKB)
IEA
GO:0007050
P29460 (UniProtKB)
IDA
GO:0010224
P29460 (UniProtKB)
IDA
GO:0010535
P29460 (UniProtKB)
IDA
GO:0016020
P29460 (UniProtKB)
IEA
GO:0016477
P29460 (UniProtKB)
IDA
GO:0019221
P29460 (UniProtKB)
IEA
GO:0019233
P29460 (UniProtKB)
IEA
GO:0019953
P29460 (UniProtKB)
TAS
GO:0030101
P29460 (UniProtKB)
IDA
GO:0032693
P29460 (UniProtKB)
IMP
GO:0032700
P29460 (UniProtKB)
IDA
GO:0032725
P29460 (UniProtKB)
IDA
GO:0032729
P29460 (UniProtKB)
IDA
GO:0032729
P29460 (UniProtKB)
IDA
GO:0032729
P29460 (UniProtKB)
IDA
GO:0032729
P29460 (UniProtKB)
IDA
GO:0032733
P29460 (UniProtKB)
IDA
GO:0032733
P29460 (UniProtKB)
TAS
GO:0032735
P29460 (UniProtKB)
IDA
GO:0032740
P29460 (UniProtKB)
IDA
GO:0032740
P29460 (UniProtKB)
IDA
GO:0032740
P29460 (UniProtKB)
IDA
GO:0032760
P29460 (UniProtKB)
IMP
GO:0032816
P29460 (UniProtKB)
IDA
GO:0032816
P29460 (UniProtKB)
IC
GO:0032819
P29460 (UniProtKB)
IDA
GO:0032946
P29460 (UniProtKB)
IMP
GO:0034105
P29460 (UniProtKB)
IC
GO:0034393
P29460 (UniProtKB)
IDA
GO:0042035
P29460 (UniProtKB)
TAS
GO:0042088
P29460 (UniProtKB)
TAS
GO:0042093
P29460 (UniProtKB)
IDA
GO:0042095
P29460 (UniProtKB)
TAS
GO:0042102
P29460 (UniProtKB)
IDA
GO:0042104
P29460 (UniProtKB)
IDA
GO:0042104
P29460 (UniProtKB)
IDA
GO:0042164
P29460 (UniProtKB)
IPI
GO:0042164
P29460 (UniProtKB)
IPI
GO:0042164
P29460 (UniProtKB)
IPI
GO:0042164
P29460 (UniProtKB)
IPI
GO:0042164
P29460 (UniProtKB)
IPI
GO:0042346
P29460 (UniProtKB)
TAS
GO:0042510
P29460 (UniProtKB)
IDA
GO:0042517
P29460 (UniProtKB)
IDA
GO:0042520
P29460 (UniProtKB)
IDA
GO:0042520
P29460 (UniProtKB)
IDA
GO:0042520
P29460 (UniProtKB)
IDA
GO:0042523
P29460 (UniProtKB)
IDA
GO:0042802
P29460 (UniProtKB)
IPI
GO:0042803
P29460 (UniProtKB)
IEA
GO:0042832
P29460 (UniProtKB)
IEA
GO:0043382
P29460 (UniProtKB)
ISS
GO:0043514
P29460 (UniProtKB)
IDA
GO:0043514
P29460 (UniProtKB)
IDA
GO:0044130
P29460 (UniProtKB)
IEA
GO:0045078
P29460 (UniProtKB)
TAS
GO:0045672
P29460 (UniProtKB)
IDA
GO:0045785
P29460 (UniProtKB)
IDA
GO:0046982
P29460 (UniProtKB)
IPI
GO:0046982
P29460 (UniProtKB)
IPI
GO:0046982
P29460 (UniProtKB)
IPI
GO:0046982
P29460 (UniProtKB)
IPI
GO:0046982
P29460 (UniProtKB)
IPI
GO:0046982
P29460 (UniProtKB)
IPI
GO:0048662
P29460 (UniProtKB)
IDA
GO:0050671
P29460 (UniProtKB)
IDA
GO:0050729
P29460 (UniProtKB)
IC
GO:0050829
P29460 (UniProtKB)
IDA
GO:0050829
P29460 (UniProtKB)
IDA
GO:0051135
P29460 (UniProtKB)
IDA
GO:0051135
P29460 (UniProtKB)
IC
GO:0051142
P29460 (UniProtKB)
IDA
GO:0051607
P29460 (UniProtKB)
IEA
GO:0070743
P29460 (UniProtKB)
IDA
GO:0071222
P29460 (UniProtKB)
IEA
GO:0071346
P29460 (UniProtKB)
IEA
GO:2000318
P29460 (UniProtKB)
ISS
GO:2000330
P29460 (UniProtKB)
ISS
GO:0005125
P29460 (UniProtKB)
IDA
GO:0005143
P29460 (UniProtKB)
TAS
GO:0008083
P29460 (UniProtKB)
IDA
GO:0045519
P29460 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 IL12B基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

String
BioGrid
IntAct
mentha
加载中…
关联基因 作用方式 资源库来源/分值

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Psoriasis 0.302990629 38 7 BeFree_CTD_human_GAD_GWASCAT_LHGDN
Asthma 0.154200471 17 2 BeFree_CTD_human_GAD_LHGDN
Crohn Disease 0.144832032 20 3 BeFree_CTD_human_GAD
Arthritis, Psoriatic 0.135178339 12 4 BeFree_CTD_human_GAD_LHGDN
Ulcerative Colitis 0.134092571 13 2 BeFree_CTD_human_GAD_LHGDN
Lupus Erythematosus, Systemic 0.12554839 5 0 BeFree_CTD_human_GAD
Ankylosing spondylitis 0.123452799 4 1 BeFree_CTD_human_GAD
Glioma 0.122367032 2 0 CTD_human_GAD
Takayasu Arteritis 0.121085767 4 1 BeFree_ORPHANET
Spontaneous abortion 0.12 1 0 CTD_human

基因相关文献

基因相关文献

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells.
Adams NM, Galitsyna A, Tiniakou I, Esteva E, Ra AC, Martinez-Krams D, Lau CM, Reyes J, Abdennur N, Shkolikov A, Yap GS, Khodadadi-Jamayran A, Dolgalev I, Mirny LA, Reizis B Sci Immunol IF: 16.4 2026-02-06
Capecitabine combined with fecal microbiota transplantation prevents colorectal cancer progression through correction of microbial dysbiosis and immune regulation.
Arshad M, Zhang CY, Gao ZK, Sun H, Xu DQ, Fan CY, Zhang BW, Geng JX, Li Y, Kotusov A, Liu SL, Zhang N, Mu XQ Sci Rep IF: 4.9 2026-03-14
CCR2 deficiency protects against doxorubicin-induced cardiac dysfunction through enhanced IL12B-dependent autophagy.
Hu L, Lin L, Chen L, Wang Y, Ning L, Tu W, Wang C, Deng S, Huang K Theranostics IF: 14.9 None
Immunomodulatory Potential of Quinoline Q3, a Selective Inhibitor of the Canonical NF-κB Pathway in Macrophages.
Michail K, Ntavaroukas P, Petriki V, Tsioupros E, Manta S, Campbell BJ, Papoutsopoulou S ChemMedChem IF: 3.5 2026-07-14
Integrated metabolomics and DNA methylation signatures and their association with flare remission in SLE.
Horton M, Johnson D, Overdahl KE, Nititham J, Taylor KE, Katz P, Chun JY, Yazdany J, Dall'Era M, Barcellos LF, Li JL, Jarmusch AK, Criswell LA, Lanata CM Lupus Sci Med IF: 4.2 2026-09-12
IL12B rs3213094 as a Predictor of Early Response to Biologic Therapy in Psoriasis: A Real-World Study in a Romanian Cohort.
Matei-Man AM, Gaal IO, Catana A, Vesa S, Senila S, Candrea E, Orasan M, Puskas A, Man AC, Mocan T Medicina (Kaunas) IF: 2.9 2026-05-28
Henoch-Schoenlein purpura-like lesions in IL12RB1 and IL12B defects-a multi-centric experience from India.
Sharma Y, Nadig P, Das J, Iyengar V, Loganathan SK, Chougule A, Gowri V, Taur P, Pilania R, Dhaliwal M, Sharma S, Chatterjee D, Suri D, Desai M, Singh S, Vignesh P, Rawat A Clin Exp Immunol IF: 3.9 2026-01-06

基因相关服务

基因相关服务

基因相关评论

基因相关评论

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