CLEC1BGene Detail-Gene Database-Genelibs

CLEC1B (C-type lectin domain family 1 member B)

symbol:: CLEC1B
locus group:: protein-coding gene
location:: 12p13.31-p13.2
gene_family:: C-type lectin domain family
alias symbol:: CLEC2|CLEC-2
alias name:: None
entrez id:: 51266
ensembl gene id:: ENSG00000165682
ucsc gene id:: uc001qwu.5
refseq accession:: NM_016509
hgnc_id:: HGNC:24356
approved reserved:: 2005-02-09

12p13.31-p13.2

CLEC1B（C-type lectin domain family 1 member B）属于C型凝集素家族（CLEC家族），是一类重要的免疫相关基因家族，其成员通常编码含有C型凝集素结构域的蛋白质，参与病原体识别、免疫调节和细胞间相互作用。CLEC1B编码的蛋白主要表达于血小板和树突状细胞，通过与配体结合参与凝血和免疫应答。其生物学功能包括促进血小板聚集和血栓形成，并在炎症反应中发挥作用。CLEC1B的配体包括某些病原体相关分子模式（PAMPs）和损伤相关分子模式（DAMPs），通过识别这些分子激活下游信号通路。突变或异常表达可能影响血小板功能，导致出血倾向或血栓性疾病。研究表明，CLEC1B与深静脉血栓形成（DVT）和某些自身免疫性疾病相关。过表达可能增加血栓风险，而降低表达可能导致止血功能障碍。CLEC1B与同家族成员（如CLEC1A、CLEC2）具有相似的结构和功能特征，均参与免疫识别和细胞信号传导。该基因家族在先天免疫和适应性免疫中发挥关键作用，通过识别糖基化模式调控免疫细胞活性。

ChineseEnglish

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

OMIM entry for CLEC1B Wikipedia entry for CLEC1B

Nucleotide sequence of CLEC1B:[NCBI]

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Protein Sequence

1MQDEDGYITL NIKTRKPALI SVGSASSSWW RVMALILLIL
41CVGMVVGLVA LGIWSVMQRN YLQGENENRT GTLQQLAKRF
81
CQYVVKQSE LKGTFKGHKC SPCDTNWRYY GDSCYGFFRH
121NLTWEESKQY CTDMNATLLK IDNRNIVEYI KARTHLIRWV
161G
LSRQKSNE VWKWEDGSVI SENMFEFLED GKGNMNCAYF
201HNGKMHPTFC ENKHYLMCER KAGMTKVDQL P

结构预测来自 AlphaFold DB（UniProt: Q9P126），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

SNP variants of CLEC1B: Showing partial SNPs

rs15635 rs476564 rs477658 rs521040 rs522837 rs531425 rs542700 rs544605 rs544783 rs566505 rs571265 rs574097 rs576031 rs581949 rs582968 rs583903 rs584856

Tissue expression of CLEC1B: [UniProt]

Forward Primer

Forward Tm

Reverse Primer

Reverse Tm

Score

TAAAGGGCACTTTCAAAGGTC

58

AGAACCCATAGCAGCTATCTC

59

GAGAGTAAGCAGTACTGCAC

58

CTGGCTTTGATGTACTCCAC

58

CTAAAGGGCACTTTCAAAGG

57

GAACCCATAGCAGCTATCTC

57

GAGAGTAAGCAGTACTGCAC

58

TGGCTTTGATGTACTCCAC

57

GAGTAAGCAGTACTGCACTG

58

CTGGCTTTGATGTACTCCAC

58

ACTAAAGGGCACTTTCAAAGG

58

AACCCATAGCAGCTATCTCC

59

No data available

Subcellular localization of CLEC1B (and its protein):

[UniProt] [GenomeNet]

plasma membrane
cytoplasm
extracellular
golgi
vesicle
cytoskeleton
endoplasmic reticulum
nucleus
endosome
lysosome
mitochondrion

Gene Ontology (GO) terms for CLEC1B:

GO ID

Protein

Source DB

GO:0004888

Q9P126 (UniProtKB)

TAS

GO:0005515

Q9P126 (UniProtKB)

IPI

GO:0005886

Q9P126 (UniProtKB)

TAS

GO:0005886

Q9P126 (UniProtKB)

TAS

GO:0005886

Q9P126 (UniProtKB)

TAS

GO:0005887

Q9P126 (UniProtKB)

IEA

GO:0006952

Q9P126 (UniProtKB)

TAS

GO:0007166

Q9P126 (UniProtKB)

TAS

GO:0030168

Q9P126 (UniProtKB)

TAS

GO:0030220

Q9P126 (UniProtKB)

IEA

GO:0030246

Q9P126 (UniProtKB)

IEA

microRNAs potentially regulating CLEC1B:

String

BioGrid

IntAct

mentha

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Interacting Gene	Interaction	Source/Score

Disease

Score

NofPmids

NofSnps

Source

Disease	Score	NofPmids	NofSnps	Source
Neoplasm Metastasis	0.003267234	3	0	BeFree_LHGDN
Rheumatoid Arthritis	0.002638474	2	0	BeFree_GAD
Coronary Artery Disease	0.002367032	1	0	GAD
Diabetes Mellitus, Insulin-Dependent	0.002367032	1	0	GAD
Hypertensive disease	0.002367032	1	0	GAD
Diabetes Mellitus, Non-Insulin-Dependent	0.002367032	1	0	GAD
Crohn Disease	0.002367032	1	0	GAD
Albuminuria	0.002367032	1	1	GAD
Blood Coagulation Disorders	0.000271442	1	0	BeFree

Identification of circulatory neuro-related proteins in Parkinson's disease: an integrated genetic-proteomic-clinical study.

Zhou H, Wang Z, Tan Z, Deng B, Yang W, Huang Z, Guo X, Li J, Wang X, Yu Y, Deng C, Zheng W, Zhang X, Chen X, Yue J, Yang C, Cui X, Poplawska-Domaszewicz K, Chaudhuri KR, Zhou Z, Xiao B, Chan LL, Foo JN, Tan EK, Wang Q EBioMedicine IF: 11.2 2026-03-00

[Establishment of a Doxorubicin-Resistant Acute Myeloid Leukemia Cell Line and Study on Its Drug Resistance Mechanisms].

Feng LL, Wang YT, Huang CF, Sun CY, Jun YL, Zhang L Zhongguo Shi Yan Xue Ye Xue Za Zhi 2026-06-00

Integrative transcriptomics elucidates core regulatory network governing human megakaryopoiesis: Insights from CD34+-derived megakaryocyte maturation.

Zhang Z, Wang Y, Liu P Thromb Res IF: 3.4 2026-06-00

Identification of STEAP4, EPC1, and CLEC1B as non-invasive candidate biomarkers for hepatocellular carcinoma using integrated bioinformatics analysis.

Khojand S, Zahmatkesh N, Hassani A, Damerchiloo Z, Nikoo Z, Heidarzadehpilehrood R Biotechnol Rep (Amst) 2026-06-00

Circulating proteomic markers are associated with measures of small and large fiber neuropathy and symptoms in type 2 diabetes.

Ponirakis G, Al-Janahi I, Elgassim E, Dalloul RSD, Petropoulos IN, Gad H, Khan A, Zaghloul HB, Ali H, Siddique MA, Mohamed FFS, Ahmed LHM, Dakroury Y, El Shewehy AMM, Saeid R, Mahjoub F, Al-Noubi MN, Sarwath H, Paul P, Kaul R, Salivon I, Zirie MA, Al-Ansari Y, Atkin SL, Schmidt F, Malik RA J Diabetes Complications IF: 3.2 2026-05-00

First exploratory GWAS of parasite resistance in Pelibuey sheep identifying biologically plausible candidate loci.

Esparza-Acebo LM, Ojeda-Robertos NF, De La Rosa-Reyna XF, Parra-Bracamonte GM Vet Parasitol Reg Stud Reports IF: 1.6 2026-08-00

Dendropanax proteus root and its major bio-phytochemicals alleviate rheumatoid arthritis by inhibiting TLR4/CLEC1B/PI3K/Akt/NF-κB pathways: proteomics, metabolomics, collagen-induced arthritis rats, MH7A cells, molecular docking, and molecular dynamic simulation.

Yang L, Yang Y, Wang Q, Liang J, Zhang S, Nie H, Zeng H, He J J Ethnopharmacol IF: 6.8 2026-02-28

Proteomic profiling of single extracellular vesicles as a promising new approach for the diagnosis and treatment modality of advanced ovarian cancer.

Wu B, Yang X, Cai Y, Wan S, Liu J, Xing J, Chen X, Zhang J, Jin Y, Yu A, Yang L NPJ Precis Oncol 2026-01-21

Nuclear receptors-mediated lipid metabolism dysregulation: A potential mechanism linking PFOA/PFOS to hepatocellular carcinoma.

Xu S, Qiao S, Zhang S, Liu C, Chen L, Dai B, Yang C, Xia L, Xiong G, Zhao L, Li J Ecotoxicol Environ Saf IF: 6.6 2026-01-15

Identification, characterisation and expression analysis of natural killer receptor genes in Chlamydia pecorum infected koalas (Phascolarctos cinereus).

Morris Katrina M, Mathew Marina, Waugh Courtney, Ujvari Beata, Timms Peter, Polkinghorne Adam, Belov Katherine BMC Genomics IF: 3.9 2016-07-01

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CLEC1B (C-type lectin domain family 1 member B)

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Gene Variants

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