CD34 (CD34 molecule)

Gene Basic Information

Gene Basic Information

symbol:
CD34
locus group:
protein-coding gene
location:
1q32.2
gene_family:
CD molecules
alias symbol:
None
alias name:
None
entrez id:
947
ensembl gene id:
ENSG00000174059
ucsc gene id:
uc001hgw.2
refseq accession:
NM_001773
hgnc_id:
HGNC:1662
approved reserved:
1990-09-10

Chromosome Location

Chromosome Location

1q32.2

Gene Summary

Gene Summary

CD34是一种高度糖基化的I型跨膜蛋白，属于CD分子家族（Cluster of Differentiation，分化簇），主要作为细胞表面标志物用于识别和分离造血干细胞（HSC）及血管内皮细胞。其生物学功能包括参与细胞间黏附、介导干细胞归巢（homing）至骨髓微环境，并可能在血管生成和炎症反应中发挥作用。CD34的表达产物通过与其他分子（如选择素L-selectin）相互作用，帮助造血干细胞锚定在骨髓基质中。该基因的主要作用位点是细胞膜，尤其在未成熟造血细胞和血管内皮细胞表面富集。CD34基因突变较为罕见，但可能影响造血干细胞的迁移和归巢能力，导致造血功能障碍或免疫缺陷。目前尚未明确CD34突变与特定疾病的直接关联，但其表达水平变化与某些血液系统疾病（如白血病）和血管肿瘤相关。CD34过表达可能促进血管增生，与肿瘤血管生成及转移相关；而降低表达可能影响造血干细胞的维持和修复能力。CD34属于唾液黏蛋白（sialomucin）家族，该家族成员共性为含有大量O-糖基化修饰和带负电荷的唾液酸残基，这类结构赋予其抗黏附特性，同时能在特定条件下转变为促黏附分子。CD34的表达水平常作为临床检测造血干细胞和血管内皮细胞的标志物，但其确切分子机制仍需进一步研究。

ChineseEnglish

The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

OMIM entry for CD34     Wikipedia entry for CD34

Gene Sequence

Gene Sequence

Nucleotide sequence of CD34:[NCBI]
Loading Gene Browser...

Encoded Protein

Encoded Protein

Protein Sequence
1MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT
41PELPTQGTFS NVSTNVSYQE TTTPSTLGST SLHPVSQHGN
81 EATTNITET TVKFTSTSVI TSVYGNTNSS VQSQTSVIST
121VFTTPANVST PETTLKPSLS PGNVSDLSTT STSLATSPTK
161P YTSSSPIL SDIKAEIKCS GIREVKLTQG ICLEQNKTSS
201CAEFKKDRGE GLARVLCGEE QADADAGAQV CSLLLAQSEV
241RP QCLLLVL ANRTEISSKL QLMKKHQSDL KKLGILDFTE
281QDVASHQSYS QKTLIALVTS GALLAVLGIT GYFLMNRRSW
321SPT GERLGE DPYYTENGGG QGYSSGPGTS PEAQGKASVN
361RGAQENGTGQ ATSRNGHSAR QHVVADTEL
结构预测来自 AlphaFold DB（UniProt: P28906），颜色表示 pLDDT 置信度（深蓝高、黄橙低）。

Gene Variants

Gene Variants

SNP variants of CD34:           Showing partial SNPs
rs2556       rs7572       rs526254       rs579475       rs656801       rs658347       rs671131       rs694748       rs859564       rs1009896       rs1009897       rs1076724       rs1076725       rs1204678       rs1204679       rs1204681       rs1204682      

Gene Expression

Gene Expression

Tissue expression of CD34:    [UniProt]

Gene expression across tissues

Gene Primers

Gene Primers

Forward Primer
Forward Tm
Reverse Primer
Reverse Tm
Score
CCAACAGAACAGAAATTTCCAG
58
GCTCAGTGAAATCTAGGATCC
58
CAACAGAACAGAAATTTCCAGC
59
GCTCAGTGAAATCTAGGATCC
58
CCAACAGAACAGAAATTTCCAG
58
CTCAGTGAAATCTAGGATCCC
57

Transcription Factors

Transcription Factors

Transcription Factors
Target Gene
Interaction Type
PubMed References
MYB
CD34
Unknown
7523384
MZF1
CD34
Unknown
8585946
RUNX1
CD34
Activation
21873977
TAL1
CD34
Repression
14715640

Gene Ontology

Subcellular localization of CD34 (and its protein):

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • plasma membrane
  • cytoplasm
  • extracellular
  • golgi
  • vesicle
  • cytoskeleton
  • endoplasmic reticulum
  • nucleus
  • endosome
  • lysosome
  • mitochondrion

Gene Ontology (GO) terms for CD34:

GO ID
Protein
Source DB
GO:0001894
P28906 (UniProtKB)
IDA
GO:0001935
P28906 (UniProtKB)
IDA
GO:0003094
P28906 (UniProtKB)
IEP
GO:0003158
P28906 (UniProtKB)
IEP
GO:0005737
P28906 (UniProtKB)
IDA
GO:0005764
P28906 (UniProtKB)
ISS
GO:0005886
P28906 (UniProtKB)
IDA
GO:0005886
P28906 (UniProtKB)
IDA
GO:0005886
P28906 (UniProtKB)
IDA
GO:0005886
P28906 (UniProtKB)
IDA
GO:0005886
P28906 (UniProtKB)
TAS
GO:0005887
P28906 (UniProtKB)
TAS
GO:0007160
P28906 (UniProtKB)
IBA
GO:0007165
P28906 (UniProtKB)
IEP
GO:0008134
P28906 (UniProtKB)
IPI
GO:0008217
P28906 (UniProtKB)
IDA
GO:0008283
P28906 (UniProtKB)
ISS
GO:0009897
P28906 (UniProtKB)
IDA
GO:0009897
P28906 (UniProtKB)
IDA
GO:0009897
P28906 (UniProtKB)
IC
GO:0009897
P28906 (UniProtKB)
IDA
GO:0009925
P28906 (UniProtKB)
ISS
GO:0010628
P28906 (UniProtKB)
IEP
GO:0010629
P28906 (UniProtKB)
IMP
GO:0016324
P28906 (UniProtKB)
ISS
GO:0016337
P28906 (UniProtKB)
IDA
GO:0030097
P28906 (UniProtKB)
IMP
GO:0030195
P28906 (UniProtKB)
IDA
GO:0030246
P28906 (UniProtKB)
IDA
GO:0032720
P28906 (UniProtKB)
IDA
GO:0032733
P28906 (UniProtKB)
IDA
GO:0035759
P28906 (UniProtKB)
ISS
GO:0036053
P28906 (UniProtKB)
ISS
GO:0038001
P28906 (UniProtKB)
IDA
GO:0042482
P28906 (UniProtKB)
IDA
GO:0043199
P28906 (UniProtKB)
IEA
GO:0045019
P28906 (UniProtKB)
IDA
GO:0045171
P28906 (UniProtKB)
IDA
GO:0045766
P28906 (UniProtKB)
IDA
GO:0045766
P28906 (UniProtKB)
IDA
GO:0048471
P28906 (UniProtKB)
IDA
GO:0048870
P28906 (UniProtKB)
IEP
GO:0050776
P28906 (UniProtKB)
TAS
GO:0050900
P28906 (UniProtKB)
ISS
GO:0060290
P28906 (UniProtKB)
IEP
GO:0061042
P28906 (UniProtKB)
IEP
GO:0071425
P28906 (UniProtKB)
IMP
GO:0071636
P28906 (UniProtKB)
IDA
GO:0071657
P28906 (UniProtKB)
IEP
GO:0071657
P28906 (UniProtKB)
IDA
GO:0071971
P28906 (UniProtKB)
IDA
GO:0072011
P28906 (UniProtKB)
IEP
GO:0072089
P28906 (UniProtKB)
IEP
GO:0072254
P28906 (UniProtKB)
IEP
GO:1900035
P28906 (UniProtKB)
IDA
GO:1900038
P28906 (UniProtKB)
IDA
GO:1900041
P28906 (UniProtKB)
IMP
GO:1900168
P28906 (UniProtKB)
IDA
GO:1901215
P28906 (UniProtKB)
IDA
GO:2001214
P28906 (UniProtKB)
IDA
GO:0007155
Q5JTA5 (UniProtKB)
IEA
GO:0016021
Q5JTA5 (UniProtKB)
IEA

Related microRNA

Related microRNA

microRNAs potentially regulating CD34:     

Gene Interactions

Gene Interactions

String
BioGrid
mentha
Reactome
Loading…
Interacting Gene Interaction Source/Score

Gene Pathways

Gene Pathways

Related Diseases

Related Diseases

Disease Score NofPmids NofSnps Source
Disease Score NofPmids NofSnps Source
Neoplastic Cell Transformation 0.12 1 0 CTD_human
Leukemia, Myelocytic, Acute 0.06897603 227 0 BeFree_LHGDN
Myeloid Leukemia, Chronic 0.039107493 125 0 BeFree_LHGDN
leukemia 0.021986792 81 0 BeFree
HIV Infections 0.01575356 48 0 BeFree_LHGDN
Gastrointestinal Stromal Tumors 0.012496258 36 0 BeFree_LHGDN
Acute Promyelocytic Leukemia 0.01114898 22 0 BeFree_LHGDN
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.010606096 20 0 BeFree_LHGDN
Primary Myelofibrosis 0.009238955 24 2 BeFree_LHGDN
Severe Combined Immunodeficiency 0.008957582 33 0 BeFree

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