Single-cell RNA and B cell receptor profiling of B cell response to SARS-CoV-2 vaccination

We generated single-cell transcriptomic and BCR sequencing data of B cells from peripheral blood samples taken from a SARS-CoV-2-antigen-naive cohort being vaccinated with the SARS-CoV-2 mRNA-1273 vaccine. Blood samples were collected at the baseline timepoint D-1 (i.e. one day prior to the initial vaccination), D+5, D+9, D+12, W8 (taken just before the second immunization), W10 and M6 post first vaccination dose. This dataset, in conjunction with other multi-omic data generated from other samples in the study, allowed us to finely map B cell, Class switch recombination (CSR) and antibody production dynamics during primary immunization in the context of vaccine-derived antigen-specific B cells.