Single-cell RNA-seq of peripheral blood mononuclear cells from Huntington's disease patients and controls

Transcriptional dysregulation is among the most prominent molecular alterations in Huntington’s disease. It is not confined to brain but is also extended to peripheral tissues and cells, enabling minimally invasive screens aimed at identifying transcriptional surrogates of the health status in HD mutation carriers. In this study, we applied single-cell RNA-seq in peripheral blood mononuclear cells (PBMCs) to determine those cellular compartments that accumulate the most prominent gene expression changes as potential sources of reliable biomarkers.