实验描述
The Psoriasis Stratification to Optimise Relevant Therapy (PSORT) consortium, prospectively recruited deeply-phenotyped discovery and refinement psoriasis patient cohorts, during the early phase of treatment with two distinct biologics, adalimumab (TNF inhibitor) and ustekinumab (IL-12/23 inhibitor). Utilising this large multi-dimensional dataset, we aimed to identify transcripts associated with specific disease endotypes, defined by clinical and phenotypic features before commencing treatment (baseline); and disease severity endotypes, defined by Psoriasis Area and Severity Index (PASI)-associated gene expression profiles
参考文献
Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity.
Rider A, Grantham HJ, Smith GR, Watson DS, Casement J, Cockell SJ, Gisby J, Foulkes AC, Henkin R, Iqbal WA, Ewen T, Amarnath S, Ng S, Zuliani P, Dand N, Stocken D, Traini C, Thomas E, Kalyana-Sundaram S, Rajpal DK, Smith KM, Barker JN, Griffiths CEM, Di Meglio P, Smith CH, Warren RB, Barnes MR, Reynolds NJ, PSORT consortium.
PMID: 41565778
样本属性
Developmental stage
adult
Age
25 year, 50 year, 54 year, 41 year, 35 year, 46 year, 34 year, 58 year, 40 year, 53 year, 56 year, 44 year, 51 year, 65 year, 45 year, ... 37 other values
Organism part
Nonlesional Skin, Lesional Skin, Whole Blood
Individual
6051, 6061, 5013, 1024, 6016, 1026, 60019, 5033, 1015, 60003, 6071, 6019, 5036, 23003, 5011, ... 131 other values
Drug
Ustekinumab, Adalimumab
Psoriasis area severity index pasi
26.8, 23.4, 5.9, 10.1, 14.6, 22.8, 19.3, 17.7, 15.8, 10.2, 13.7, 6.9, 2.1, 28.3, 1, ... 191 other values
Disease onset type
Early-onset, NA, Late-onset
Age of onset
25 year, 54 year, 41 year, 35 year, NA year, 6 year, 34 year, 40 year, 53 year, 3 year, 9 year, 7 year, 44 year, 51 year, 45 year, ... 37 other values
Biologic naive patient
Yes, No
Anti tnf naive patient
Yes, No
Psoriatic arthritis
Negative, Positive
Body mass index
34.08660523, 33.50723014, 27.47170713, 27.33564014, 28.5868742, 32.60588843, 26.953125, 42.0508468, 27.44454504, 33.08128544, 30.11937557, 27.23922448, 28.0159401, 23.35555338, 24.44545043, ... 130 other values
Hla_c0602 carrier
1, 2, 0, NA
