实验描述
Mice are cancer-prone, whereas naked mole-rats are cancer-resistant. Because fibroblasts support the development of skin cancer, SCC25 cells were co-cultured with either mouse or naked-mole rat cells and the difference in SCC25 cells grown alone or with the different types of fibroblasts were compared. Cells were grown together for two days, then FACS-sorted and bulk-sequenced separately.
样本属性
Genotype
wild type genotype
Organism
Heterocephalus glaber, Homo sapiens, Mus Musculus
Cell line
MEF3T3, Ispr07, scc-25
Developmental stage
not available, adult, embryo
Disease
normal, squamous cell carcinoma
Organism part
tongue, not available, embryo
Cell type
fibroblast, epithelial
Growth condition
SCC25 cells co-cultured with mouse fibroblasts, SCC25 cells co-cultured with naked mole-rat fibroblasts, Naked mole-rat fibroblasts co-cultured with SCC25 cells, Naked mole-rat fibroblasts alone, SCC25 cells alone, Mouse fibroblast co-cultured with SCC25 cells, Mouse fibroblasts alone