Investigation of the Dietary Ingestion of 2-Aminoanthracene in Sprague Dawley Rats using genomic tools.

The present research focuses on 2-aminoanthracene (2AA), recognized as a derivative of PAHs. The Centers for Disease Control and Prevention (CDC) characterizes PAHs as exhibiting properties that adversely affect the health of various living organisms. These compounds increase the risk of neoplasms in humans and animals and are implicated in the increase of genetic mutations. 2AA, an aromatic amine, has demonstrated elevated carcinogenic and mutagenic potential on animals7. In the long term, exposure to PAHs may cause damage to the liver and kidneys. Furthermore, 2AA has been associated with the onset of early diabetic symptoms9. Consumption of 2AA by Sprague-Dawley rats has shown inflammatory and genetic overregulation, increased glucose, and decreased insulin production. This study aims to examine the hepatic impact of 2AA ingestion by Sprague-Dawley Rats. Rats have anatomical structures of the organs similar to those of humans, so they are suitable for research in biomedical science.