BRAT1 Links Integrator and Defective RNA Processing with Neurodegeneration

We have identified differentially expressed genes and defects in processing of UsnRNAs in BRAT1-deficient and BRAT1-mutated patient cells by RNA-sequencing and BRAT1 as a structural and functional component of Integrator, linking defects in this critical endonuclease complex with hereditary neurodegenerative disease. Due to the sensitive nature of the data, raw data files have not been uploaded.