NPM‐ALK permits the survival of thymic T cells with aberrant T cell receptor rearrangements enabling thymic escape and tumor development

·发布 2016年1月5日 ·更新 2016年1月9日

样本数

实验数

芯片平台

实验描述

We present evidence to support a new model of Anaplastic Large Cell Lymphoma (ALCL) pathogenesis in which the malignancy is initiated in early thymocytes, prior to TCR rearrangement which is bypassed in NPM‐ALK transgenic mice following Notch1 expression. In support, we show that T cell receptor (TCR) rearrangements are aberrant in some human ALCL, yielding events that would not normally be permissive for survival during T cell development. However, a TCR is required for thymic egress and subsequent development of peripheral tumors in mice yet this TCR must be down‐regulated for T‐cell lymphomagenesis. Children affected by ALCL may thus harbor lymphoma-initiating cells in the thymocyte population that seeds relapse after chemotherapy. comparative genomic hybridization data from 43 human Anaplastic Large Cell Lymphoma (ALCL) samples and control samples

芯片平台

A-GEOD-10123

Agilent-022060 SurePrint G3 Human CGH Microarray 4x180K (Feature Number version)（43 例）

样本属性

organism

Homo sapiens

organism part

healthy control DNA, Tumor

sex

female, male

实验信息

登记号

E-GEOD-67131

GEO 编号

GSE67131

实验类型

comparative genomic hybridization by array

物种

Homo sapiens

发布日期

2016年1月5日

更新日期

2016年1月9日

提交者

Laurence Lamant、 Patrick Villarese、 Laurence Brugières、 Tim Malcolm、 Elizabeth Hook、 Elizabeth Macintyre、 Suzanne Turner、 Vahid Asnafi、 Shahid Mian、 Mariusz Wasik、 Amos Burke、 Camilla Fairbairn、 Amélie Trinquand、 Dominique Payet、 Katherine Hughes、 Lukas Kenner、 Olaf Merke、 Ana‐Iris Schiefer、 Mohamed BELHOCINE、 Martin Turner

外部链接

ArrayExpress 原始页 NCBI GEO：GSE67131

分析服务

NPM‐ALK permits the survival of thymic T cells with aberrant T cell receptor rearrangements enabling thymic escape and tumor development

联系地址

微信公众号