Expression of SUDHL-1 cell line treated by ALK inhibitors

·发布 2013年10月31日 ·更新 2015年7月20日

样本数

实验数

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相关文献

实验描述

In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in response to ALK inhibition. The ALK+TCL Sudhl-1 cell line was treated in triplicates with the ALK inhibitor, CEP-14083, or the compound's solvent for 6 h. The isolated RNA was reverse-transcribed, biotin-labeled, and hybridized to the U133 Plus 2.0 array chips (Affymetrix). Microarray data were normalized using the MAS5 algorithm and analyzed using Partek GS (Partek).

参考文献

Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming

Marzec M, Halasa K, Liu X, Wang HY, Cheng M, Baldwin D, Tobias JW, Schuster SJ, Woetmann A, Zhang Q, Turner SD, Ødum N, Wasik MA

PMID: 24218456

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A-AFFY-44

Affymetrix GeneChip Human Genome U133 Plus 2.0 [HG-U133_Plus_2]（6 例）

样本属性

cell line

SUDHL1

disease

anaplastic large cell lymphoma

organism

Homo sapiens

实验信息

登记号

E-GEOD-50803

GEO 编号

GSE50803

实验类型

transcription profiling by array

物种

Homo sapiens

发布日期

2013年10月31日

更新日期

2015年7月20日

提交者

Xiaobin Liu、 John W Tobia、 Mariusz A Wasik、 Michal Marzec、 Qian Zhang、 Suzanne D Turner、 Stephen J Schuster、 Mangeng Cheng、 Wasik A Mariusz、 Krzysztof Halasa、 Hong Y Wang、 Anders Woetmann、 Donald Baldwin、 Niels Odum

外部链接

ArrayExpress 原始页 NCBI GEO：GSE50803

分析服务

Expression of SUDHL-1 cell line treated by ALK inhibitors

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